BR112015023433A2 - métodos para regular o metabolismo de nitrogênio durante a produção de etanol a partir de milho por cepas de leveduras metabolicamente modificadas geneticamente - Google Patents

métodos para regular o metabolismo de nitrogênio durante a produção de etanol a partir de milho por cepas de leveduras metabolicamente modificadas geneticamente

Info

Publication number
BR112015023433A2
BR112015023433A2 BR112015023433A BR112015023433A BR112015023433A2 BR 112015023433 A2 BR112015023433 A2 BR 112015023433A2 BR 112015023433 A BR112015023433 A BR 112015023433A BR 112015023433 A BR112015023433 A BR 112015023433A BR 112015023433 A2 BR112015023433 A2 BR 112015023433A2
Authority
BR
Brazil
Prior art keywords
methods
ethanol production
genetically modified
yeast strains
modified yeast
Prior art date
Application number
BR112015023433A
Other languages
English (en)
Inventor
Argyros Aaron
Barrett Trisha
Original Assignee
Lallemand Hungary Liquidity Man Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lallemand Hungary Liquidity Man Llc filed Critical Lallemand Hungary Liquidity Man Llc
Publication of BR112015023433A2 publication Critical patent/BR112015023433A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06Ethanol, i.e. non-beverage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411Amylases
    • C12N9/2428Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y104/00Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/01Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
    • C12Y104/01002Glutamate dehydrogenase (1.4.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y104/00Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/01Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
    • C12Y104/01004Glutamate dehydrogenase (NADP+) (1.4.1.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y104/00Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/01Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
    • C12Y104/01014Glutamate synthase (NADH) (1.4.1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y603/00Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/01Acid-ammonia (or amine)ligases (amide synthases)(6.3.1)
    • C12Y603/01002Glutamate-ammonia ligase (6.3.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y603/00Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04006Urea carboxylase (6.3.4.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06Ethanol, i.e. non-beverage
    • C12P7/08Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
    • C12P7/10Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001Alcohol dehydrogenase (1.1.1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0101Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y197/00Other oxidoreductases (1.97)
    • C12Y197/01Other oxidoreductases (1.97) other oxidoreductases (1.97.1)
    • C12Y197/01004[Formate-C-acetyltransferase]-activating enzyme (1.97.1.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01054Formate C-acetyltransferase (2.3.1.54), i.e. pyruvate formate-lyase or PFL
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01003Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23Aspartic endopeptidases (3.4.23)
    • C12Y304/23041Yapsin 1 (3.4.23.41)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

resumo patente de invenção: "métodos para regular o metabolismo de nitrogênio durante a produção de etanol a partir de milho por cepas de leveduras metabolicamente modificadas geneticamente". a presente invenção refere-se a um mecanismo para reduzir a produção de glicerol e aumentar a utilização de nitrogênio e a produção de etanol de micro-organismos recombinantes. um aspecto desta invenção refere-se a cepas de s. cerevisiae com produtividade de glicerol reduzida para proporcionar um benefício cinético a partir da maior concentração de nitrogênio sem sacrificar o rendimento de etanol. um segundo aspecto da invenção refere-se a modificações metabólicas resultando no transporte e/ou metabolismo intracelular alterados das fontes de nitrogênio presentes em massa de milho.
BR112015023433A 2013-03-15 2014-03-13 métodos para regular o metabolismo de nitrogênio durante a produção de etanol a partir de milho por cepas de leveduras metabolicamente modificadas geneticamente BR112015023433A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361800323P 2013-03-15 2013-03-15
PCT/US2014/025460 WO2014151318A2 (en) 2013-03-15 2014-03-13 Methods for regulating nitrogen metabolism during the production of ethanol from corn by metabolically engineered yeast strains

Publications (1)

Publication Number Publication Date
BR112015023433A2 true BR112015023433A2 (pt) 2017-11-28

Family

ID=50774844

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023433A BR112015023433A2 (pt) 2013-03-15 2014-03-13 métodos para regular o metabolismo de nitrogênio durante a produção de etanol a partir de milho por cepas de leveduras metabolicamente modificadas geneticamente

Country Status (7)

Country Link
US (3) US10604772B2 (pt)
EP (1) EP2970864B1 (pt)
CN (1) CN105209600A (pt)
BR (1) BR112015023433A2 (pt)
CA (2) CA2905133C (pt)
DK (1) DK2970864T3 (pt)
WO (1) WO2014151318A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970864B1 (en) * 2013-03-15 2020-10-28 Lallemand Hungary Liquidity Management LLC Methods for regulating nitrogen metabolism during the production of ethanol from corn by metabolically engineered yeast strains
CN105985969B (zh) * 2015-02-15 2019-11-12 安琪酵母股份有限公司 具有糖化功能的基因工程酵母及其制法和应用
WO2016140925A1 (en) 2015-03-02 2016-09-09 Synthetic Genomics, Inc. Regulatory elements from labyrinthulomycetes microorganisms
CN105861348B (zh) * 2016-06-14 2019-04-23 江南大学 一株低产尿素的酿酒酵母及其在食品生产中的应用
CN105861345B (zh) * 2016-06-14 2019-05-17 江南大学 一株低产尿素、产风味的库德里阿兹威毕赤酵母及其在食品发酵中的应用
US10633454B2 (en) 2016-11-01 2020-04-28 Conagen Inc. Expression of modified glycoproteins and glycopeptides
DK3559246T3 (da) * 2016-12-20 2022-09-05 Dsm Ip Assets Bv Forbedrede gærstammer til ethanolproduktion
EP3577239A1 (en) * 2017-02-02 2019-12-11 Lallemand Hungary Liquidity Management LLC Heterologous protease expression for improving alcoholic fermentation
CN107739086B (zh) * 2017-03-31 2020-04-28 青岛锦龙弘业环保有限公司 一种高盐度废水的脱氮方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69931162T2 (de) 1998-07-10 2007-03-29 Fluxome Sciences As Metabolisch veränderte mikrobiellen zelle mit veränderten metabolitherstellung
SE0400816D0 (sv) * 2004-03-26 2004-03-26 Forskarpatent I Syd Ab Mutated xylose reductase in xylose-fermentation by S. Cerevisiae
WO2009058276A1 (en) 2007-11-01 2009-05-07 Mascoma Corporation Product recovery from fermentation of lignocellulosic biomass
CA2641003C (en) 2008-03-20 2012-01-03 Greenfield Ethanol Inc. Genetically modified yeast strain
KR20110007608A (ko) 2008-04-14 2011-01-24 더 유니버시티 오브 브리티쉬 콜롬비아 변형된 전달체 발현을 통해 에틸카바메이트 생산을 최소화하기 위한 효모의 기능 향상
EP2277989A1 (en) 2009-07-24 2011-01-26 Technische Universiteit Delft Fermentative glycerol-free ethanol production
WO2011140386A2 (en) * 2010-05-05 2011-11-10 Mascoma Corporation Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate
CN103649321B (zh) 2011-04-05 2019-07-16 拉勒曼德匈牙利流动性管理有限责任公司 用于通过添加交替电子受体改善微生物中的产品收率和产量的方法
WO2014081803A1 (en) 2012-11-20 2014-05-30 Mascoma Corporation An electron consuming ethanol production pathway to displace glycerol formation in s. cerevisiae
EP2970864B1 (en) * 2013-03-15 2020-10-28 Lallemand Hungary Liquidity Management LLC Methods for regulating nitrogen metabolism during the production of ethanol from corn by metabolically engineered yeast strains

Also Published As

Publication number Publication date
WO2014151318A2 (en) 2014-09-25
WO2014151318A3 (en) 2014-11-20
US20200157578A1 (en) 2020-05-21
EP2970864A2 (en) 2016-01-20
US20160017377A1 (en) 2016-01-21
CA2905133C (en) 2024-03-05
DK2970864T3 (da) 2021-02-01
CA2905133A1 (en) 2014-09-25
US11946089B2 (en) 2024-04-02
CA3187926A1 (en) 2014-09-25
EP2970864B1 (en) 2020-10-28
US10604772B2 (en) 2020-03-31
US11274319B2 (en) 2022-03-15
CN105209600A (zh) 2015-12-30
US20220177930A1 (en) 2022-06-09

Similar Documents

Publication Publication Date Title
BR112015023433A2 (pt) métodos para regular o metabolismo de nitrogênio durante a produção de etanol a partir de milho por cepas de leveduras metabolicamente modificadas geneticamente
MY176863A (en) Ibat inhibitors for treatment of metabolic disorders and related conditions
UA112295C2 (uk) Обробка альфа/бета-титанових сплавів
WO2013052965A3 (en) Control of whole body energy homeostasis by microrna regulation
BR112015005048A8 (pt) métodos para tratar dermatite atópica por administração de antagonista il-4r
BR112013008981A2 (pt) Célula de levedura que fermenta pentose e glicose
BR112014031425A2 (pt) microrganismo recombinante para produção fermentativa de metionina
EA201491418A1 (ru) Рекомбинантные микроорганизмы и способы их применения
BR112015005416A2 (pt) produção de ácidos orgânicos por meio de fermentação em baixo ph
EA201500701A1 (ru) Способ создания вакцины против микоплазм
BR112019000588A2 (pt) uso de etanologênios produtores de bacteriocina na produção de biocombustível
ECSP13012702A (es) Productos alimentarios que comprenden grano integral hidrolizado
BR112013020216A2 (pt) Processo para produzir substância-alvo através do processo de fermentação
CY1116303T1 (el) Παραγωγο ακυλβενζολιου
BR112018004548A2 (pt) célula eucariótica com produção aumentada de produto de fermentação
BR112013029388A2 (pt) processos de produção de produtos de fermentação voláteis auxiliados pelo sol
RU2010111209A (ru) Способ обогащения стимулирующей подкормки для пчел
BR112015012946A2 (pt) processo de alimentação em lote para açúcares de fermentação
WO2012103263A3 (en) Compositions and methods for malate and fumarate production
李强 et al. Clinical features of fungal septicemia in 18 premature infants
CN104738173A (zh) 酸奶饮料配方
UA68550U (ru) Способ холодного кондиционирования зерна пшеницы
Yong-Hu et al. The Development of Local Education in the Social Transformation of the Early Years of Republic of China
黄卫峰 Chen Kun will Hold an Individual Concert
TH135751A (th) เซลล์ยีสต์สำหรับหมักเพนโตสและกลูโคส

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25G Requested change of headquarter approved

Owner name: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC (HU)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time