BR112015018255A2 - Usos de vetores que compreendem sequência de ácido nucléico de um gene para a preparação de medicamentos para o tratamento e a prevenção de cardiomiopatia - Google Patents
Usos de vetores que compreendem sequência de ácido nucléico de um gene para a preparação de medicamentos para o tratamento e a prevenção de cardiomiopatiaInfo
- Publication number
- BR112015018255A2 BR112015018255A2 BR112015018255A BR112015018255A BR112015018255A2 BR 112015018255 A2 BR112015018255 A2 BR 112015018255A2 BR 112015018255 A BR112015018255 A BR 112015018255A BR 112015018255 A BR112015018255 A BR 112015018255A BR 112015018255 A2 BR112015018255 A2 BR 112015018255A2
- Authority
- BR
- Brazil
- Prior art keywords
- cardiomyopathy
- gene
- acid sequence
- vectors
- drugs
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y116/00—Oxidoreductases oxidizing metal ions (1.16)
- C12Y116/03—Oxidoreductases oxidizing metal ions (1.16) with oxygen as acceptor (1.16.3)
- C12Y116/03001—Ferroxidase (1.16.3.1), i.e. ceruloplasmin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
USOS DE VETORES QUE COMPREENDEM SEQUÊNCIA DE ÁCIDO NUCLÉICO DE UM GENE PARA A PREPARAÇÃO DE MEDICAMENTOS PARA O TRATAMENTO E A PREVENÇÃO DE CARDIOMIOPATIA. A presente invenção diz respeito a um método para prevenir ou tratar cardiomiopatia devido à insuficiência de energia em um indivíduo em necessidade do mesmo, compreendendo administrar ao dito indivíduo uma quantidade terapeuticamente eficaz de um vetor que compreende uma se-quência de ácido nucléico de um gene que pode restaurar a insuficiência de energia. Mais parti-cularmente, a invenção diz respeito a um método para prevenir ou tratar uma cardiomiopatia associada com a ataxia de Friedreich em um indivíduo em necessidade do mesmo, compreen-dendo administrar ao dito indivíduo uma quantidade terapeuticamente eficaz de um vetor que compreende um ácido nucléico que codifica a frataxina (FXN).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/756,651 US9066966B2 (en) | 2013-02-01 | 2013-02-01 | Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia |
PCT/EP2014/051966 WO2014118346A1 (en) | 2013-02-01 | 2014-01-31 | Methods and pharmaceutical composition for the treatment and the prevention of cardiomyopathy due to energy failure |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015018255A2 true BR112015018255A2 (pt) | 2017-08-22 |
Family
ID=50033540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015018255A BR112015018255A2 (pt) | 2013-02-01 | 2014-01-31 | Usos de vetores que compreendem sequência de ácido nucléico de um gene para a preparação de medicamentos para o tratamento e a prevenção de cardiomiopatia |
Country Status (10)
Country | Link |
---|---|
US (7) | US9066966B2 (pt) |
EP (2) | EP2950824A1 (pt) |
AU (5) | AU2014211315A1 (pt) |
BR (1) | BR112015018255A2 (pt) |
CA (1) | CA2900135A1 (pt) |
EA (1) | EA201500802A1 (pt) |
IL (2) | IL240311A0 (pt) |
MX (2) | MX2015009963A (pt) |
WO (1) | WO2014118346A1 (pt) |
ZA (2) | ZA201506093B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9066966B2 (en) * | 2013-02-01 | 2015-06-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia |
RU2716991C2 (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
JP6863891B2 (ja) | 2014-11-14 | 2021-04-21 | ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. | 調節性ポリヌクレオチド |
CA2970730A1 (en) * | 2015-01-16 | 2016-07-21 | Voyager Therapeutics, Inc. | Central nervous system targeting polynucleotides |
WO2016150964A1 (en) * | 2015-03-23 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment and the prevention of neurological phenotype associated with friedreich ataxia |
US10617770B2 (en) * | 2015-04-24 | 2020-04-14 | University Of Florida Research Foundation, Incorporated | AAV vector for treatment of Friedreich's ataxia |
KR102200642B1 (ko) * | 2015-11-05 | 2021-01-12 | 뱀부 테라퓨틱스 인코포레이티드 | 유전자 치료를 위한 변형된 프리드라이히 운동실조증 유전자 및 벡터 |
WO2017165167A1 (en) * | 2016-03-23 | 2017-09-28 | The Regents Of The University Of California | Methods of treating mitochondrial disorders |
US10517877B2 (en) | 2016-03-30 | 2019-12-31 | Wisconsin Alumni Research Foundation | Compounds and methods for modulating frataxin expression |
IL302748A (en) | 2016-05-18 | 2023-07-01 | Voyager Therapeutics Inc | modulatory polynucleotides |
JP7165357B2 (ja) * | 2016-07-26 | 2022-11-04 | コーネル ユニヴァーシティー | アルデヒドデヒドロゲナーゼ欠損症の治療のための遺伝子治療 |
CN110139933B (zh) | 2016-11-09 | 2024-03-08 | 英特瑞克斯顿股份有限公司 | 共济蛋白表达构建体 |
US11759533B2 (en) | 2017-03-29 | 2023-09-19 | Wisconsin Alumni Research Foundation | Methods and compositions for modulating gene expression |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
RS64553B1 (sr) * | 2017-10-17 | 2023-10-31 | Gentec S A | Vektori za lečenje fridrajhove ataksije |
SG11202009452WA (en) | 2018-04-03 | 2020-10-29 | Stridebio Inc | Antibody-evading virus vectors |
KR20240014102A (ko) * | 2018-06-29 | 2024-01-31 | 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 | 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법 |
AR118465A1 (es) | 2019-03-21 | 2021-10-06 | Stridebio Inc | Vectores de virus adenoasociados recombinantes |
IL292297A (en) | 2019-10-17 | 2022-06-01 | Stridebio Inc | Adeno-associated viral vectors for the treatment of Niemann-Pick type c disease |
WO2023150563A1 (en) * | 2022-02-01 | 2023-08-10 | Cornell University | Methods and pharmaceutical compositions for the treatment and the prevention of cardiomyopathy associated with friedreich ataxia |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5173A (en) | 1847-06-26 | Machinery for | ||
US941A (en) | 1838-09-22 | Machine for sawing shingles and staves | ||
US414A (en) | 1837-09-28 | Moetise-latch foe | ||
US5139A (en) | 1847-06-05 | Cajsfkles | ||
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
AU8200191A (en) | 1990-07-09 | 1992-02-04 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
JP3534749B2 (ja) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
DE69434860T2 (de) | 1993-02-22 | 2007-03-15 | The Rockefeller University | Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion |
FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
CA2342283C (en) * | 1998-09-11 | 2004-05-25 | The Regents Of The University Of California | Recombinant adenovirus for tissue specific expression in heart |
JP4520569B2 (ja) * | 2000-02-18 | 2010-08-04 | 照彦 豊岡 | 拡張型心筋症の遺伝子治療剤 |
EP2750686B1 (en) * | 2011-06-17 | 2017-06-14 | Shire Human Genetic Therapies, Inc. | Polypeptide comprising frataxin and a c-terminal mitochondria penetrating peptide for use in the treatment of friedreich's ataxia |
US9066966B2 (en) * | 2013-02-01 | 2015-06-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia |
US10337072B2 (en) * | 2015-01-08 | 2019-07-02 | The Board Of Trustees Of The University Of Illinois | Copy number detection and methods |
WO2016150964A1 (en) * | 2015-03-23 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment and the prevention of neurological phenotype associated with friedreich ataxia |
-
2013
- 2013-02-01 US US13/756,651 patent/US9066966B2/en active Active
-
2014
- 2014-01-31 CA CA2900135A patent/CA2900135A1/en active Pending
- 2014-01-31 BR BR112015018255A patent/BR112015018255A2/pt not_active Application Discontinuation
- 2014-01-31 EP EP14702565.4A patent/EP2950824A1/en not_active Ceased
- 2014-01-31 WO PCT/EP2014/051966 patent/WO2014118346A1/en active Application Filing
- 2014-01-31 EP EP23201456.3A patent/EP4324845A3/en active Pending
- 2014-01-31 AU AU2014211315A patent/AU2014211315A1/en not_active Abandoned
- 2014-01-31 MX MX2015009963A patent/MX2015009963A/es unknown
- 2014-01-31 EA EA201500802A patent/EA201500802A1/ru unknown
- 2014-01-31 US US14/764,065 patent/US20160024526A1/en not_active Abandoned
-
2015
- 2015-05-21 US US14/718,696 patent/US10337027B2/en active Active
- 2015-07-31 MX MX2021000533A patent/MX2021000533A/es unknown
- 2015-08-02 IL IL240311A patent/IL240311A0/en unknown
- 2015-08-21 ZA ZA2015/06093A patent/ZA201506093B/en unknown
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2017
- 2017-05-02 ZA ZA2017/03041A patent/ZA201703041B/en unknown
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2018
- 2018-03-09 US US15/916,907 patent/US20180334687A1/en not_active Abandoned
- 2018-04-20 AU AU2018202783A patent/AU2018202783A1/en not_active Abandoned
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2019
- 2019-05-14 US US16/411,997 patent/US20200157564A1/en not_active Abandoned
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2020
- 2020-01-21 AU AU2020200408A patent/AU2020200408A1/en not_active Abandoned
- 2020-11-24 US US17/103,783 patent/US20210340565A1/en active Pending
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2021
- 2021-04-05 US US17/222,500 patent/US20220090128A1/en not_active Abandoned
- 2021-12-09 AU AU2021282480A patent/AU2021282480A1/en not_active Abandoned
- 2021-12-15 IL IL289016A patent/IL289016A/en unknown
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2024
- 2024-02-19 AU AU2024201048A patent/AU2024201048A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20140221462A1 (en) | 2014-08-07 |
AU2024201048A1 (en) | 2024-03-14 |
EP4324845A3 (en) | 2024-04-17 |
EP2950824A1 (en) | 2015-12-09 |
AU2020200408A1 (en) | 2020-02-13 |
EA201500802A1 (ru) | 2016-01-29 |
AU2014211315A1 (en) | 2015-08-13 |
US20150313969A1 (en) | 2015-11-05 |
NZ710497A (en) | 2021-01-29 |
MX2015009963A (es) | 2016-03-04 |
WO2014118346A1 (en) | 2014-08-07 |
US20220090128A1 (en) | 2022-03-24 |
IL289016A (en) | 2022-02-01 |
CA2900135A1 (en) | 2014-08-07 |
EP4324845A2 (en) | 2024-02-21 |
MX2021000533A (es) | 2021-04-19 |
AU2021282480A1 (en) | 2022-01-06 |
US10337027B2 (en) | 2019-07-02 |
US20160024526A1 (en) | 2016-01-28 |
US9066966B2 (en) | 2015-06-30 |
AU2018202783A1 (en) | 2018-05-24 |
US20200157564A1 (en) | 2020-05-21 |
US20210340565A1 (en) | 2021-11-04 |
US20180334687A1 (en) | 2018-11-22 |
ZA201506093B (en) | 2023-12-20 |
ZA201703041B (en) | 2023-12-20 |
IL240311A0 (en) | 2015-09-24 |
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