BR112015003305A2 - parafuso cirúrgico de elução de fármaco - Google Patents
parafuso cirúrgico de elução de fármacoInfo
- Publication number
- BR112015003305A2 BR112015003305A2 BR112015003305A BR112015003305A BR112015003305A2 BR 112015003305 A2 BR112015003305 A2 BR 112015003305A2 BR 112015003305 A BR112015003305 A BR 112015003305A BR 112015003305 A BR112015003305 A BR 112015003305A BR 112015003305 A2 BR112015003305 A2 BR 112015003305A2
- Authority
- BR
- Brazil
- Prior art keywords
- drug eluting
- surgical screw
- actuator
- drug
- drive recess
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 11
- 229940079593 drug Drugs 0.000 title abstract 9
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8605—Heads, i.e. proximal ends projecting from bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8605—Heads, i.e. proximal ends projecting from bone
- A61B17/861—Heads, i.e. proximal ends projecting from bone specially shaped for gripping driver
- A61B17/8615—Heads, i.e. proximal ends projecting from bone specially shaped for gripping driver at the central region of the screw head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/866—Material or manufacture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8685—Pins or screws or threaded wires; nuts therefor comprising multiple separate parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00889—Material properties antimicrobial, disinfectant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00893—Material properties pharmaceutically effective
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B2017/561—Implants with special means for releasing a drug
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo patente de invenção: "parafuso cirúrgico de elução de fármaco". a presente invenção fornece um parafuso cirúrgico de elução de fármaco e um método de fabricação de um parafuso cirúrgico de elução de fármaco. o parafuso cirúrgico de elução de fármaco pode incluir uma haste que tem uma porção rosqueada, uma cabeça que tem uma reentrância de acionamento disposta em uma extremidade proximal da haste, tendo a reentrância de acionamento uma região de reservatório e uma região de engate do acionador e pelo menos um ou mais componentes de elução de fármacos dispostos dentro da região de reservatório da reentrância de acionamento de um modo que não prejudica consideravelmente uma conexão entre um acionador e o parafuso cirúrgico, quando o acionador está disposto operacionalmente dentro da região de engate do acionador, cada um dos pelo menos um ou mais componentes de elução de fármacos incluindo uma matriz carreadora e um agente terapêutico, sendo que o agente terapêutico representa ao menos 20%, em peso, do componente de elução de fármaco antes de qualquer implantação do parafuso cirúrgico de elução de fármaco. 1/1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261683262P | 2012-08-15 | 2012-08-15 | |
US61/683,262 | 2012-08-15 | ||
PCT/US2013/054671 WO2014028449A1 (en) | 2012-08-15 | 2013-08-13 | Drug eluting surgical screw |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015003305A2 true BR112015003305A2 (pt) | 2017-07-04 |
BR112015003305B1 BR112015003305B1 (pt) | 2021-12-21 |
Family
ID=49004048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015003305-9A BR112015003305B1 (pt) | 2012-08-15 | 2013-08-13 | Parafuso cirúrgico de elução de fármaco |
Country Status (10)
Country | Link |
---|---|
US (4) | US9364273B2 (pt) |
EP (2) | EP2884927B1 (pt) |
JP (1) | JP6312677B2 (pt) |
KR (1) | KR102191658B1 (pt) |
CN (1) | CN104582612B (pt) |
BR (1) | BR112015003305B1 (pt) |
CA (1) | CA2882284C (pt) |
IN (1) | IN2015DN01068A (pt) |
TW (1) | TWI613991B (pt) |
WO (1) | WO2014028449A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9364273B2 (en) | 2012-08-15 | 2016-06-14 | DePuy Synthes Products, Inc. | Drug eluting surgical screw |
US10537373B2 (en) * | 2015-04-24 | 2020-01-21 | Biomet Sports Medicine, Llc | Porous implants with injectable capabilities |
WO2017146627A1 (en) * | 2016-02-26 | 2017-08-31 | Neuronano Ab | Method of implantation of cell aggregates and tissue fragments |
AU2017226480A1 (en) * | 2016-02-29 | 2018-08-16 | Medtronic Sofamor Danek, Co., Ltd. | Set screw for antibacterial device to be implanted in vivo |
EP4277689A1 (en) | 2021-01-15 | 2023-11-22 | Diffusion RX, Inc. | Joint implant with constant and continuous release of therapeutic agent |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
US4476590A (en) * | 1980-03-27 | 1984-10-16 | National Research Development Corporation | Antimicrobial surgical implants |
JPS5770816A (en) * | 1980-10-17 | 1982-05-01 | Ono Pharmaceut Co Ltd | Multilayered film preparation of prostagladin of prolonged action |
US4905680A (en) * | 1986-10-27 | 1990-03-06 | Johnson & Johnson Orthopaedics, Inc. | Absorbable bone plate |
US5387419A (en) * | 1988-03-31 | 1995-02-07 | The University Of Michigan | System for controlled release of antiarrhythmic agents |
US5985317A (en) * | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
TW402930U (en) * | 1999-02-12 | 2000-08-21 | Yang Je Jung | Improvement of marrow internal nail structure |
EP1330270A2 (en) * | 2000-11-03 | 2003-07-30 | Control Delivery Systems, Inc. | Sustained release device for treating conditions of the joint |
US20050203612A1 (en) * | 2000-12-22 | 2005-09-15 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
US7235079B2 (en) * | 2004-11-18 | 2007-06-26 | Acumed Llc | Composite bone fasteners |
BR0308053A (pt) * | 2002-02-28 | 2004-12-28 | Novartis Ag | Stents revestidos com n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina |
US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
US20070053963A1 (en) * | 2004-01-13 | 2007-03-08 | Hotchkiss Robert N | Drug delivery to a joint |
US20050250838A1 (en) * | 2004-05-04 | 2005-11-10 | Challapalli Prasad V | Formulation for sustained delivery |
US8535357B2 (en) * | 2004-12-09 | 2013-09-17 | Biomet Sports Medicine, Llc | Continuous phase compositions for ACL repair |
US8123749B2 (en) * | 2005-03-24 | 2012-02-28 | Depuy Spine, Inc. | Low profile spinal tethering systems |
US9247973B2 (en) * | 2007-09-28 | 2016-02-02 | DePuy Synthes Products, Inc. | Anti-microbial implant |
US20090163919A1 (en) | 2007-12-19 | 2009-06-25 | Peter Tarcha | Devices, systems, and methods for delivery of a pharmaceutical to a subject's spine |
WO2010019788A1 (en) * | 2008-08-13 | 2010-02-18 | Smed-Ta/Td. Llc | Drug delivery implants |
US20100249783A1 (en) * | 2009-03-24 | 2010-09-30 | Warsaw Orthopedic, Inc. | Drug-eluting implant cover |
CA2797110C (en) | 2010-04-22 | 2020-07-21 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
US9211175B2 (en) * | 2010-07-08 | 2015-12-15 | Covidien Lp | Self-detachable medical devices |
US20120109111A1 (en) * | 2010-10-29 | 2012-05-03 | Empire Technology Development Llc | Fenestration system |
US9364273B2 (en) | 2012-08-15 | 2016-06-14 | DePuy Synthes Products, Inc. | Drug eluting surgical screw |
US10307194B2 (en) * | 2017-08-01 | 2019-06-04 | Warsaw Orthopedic, Inc. | Spinal implant and method of manufacture |
-
2013
- 2013-03-13 US US13/800,342 patent/US9364273B2/en active Active
- 2013-08-13 EP EP13751041.8A patent/EP2884927B1/en active Active
- 2013-08-13 JP JP2015527529A patent/JP6312677B2/ja not_active Expired - Fee Related
- 2013-08-13 WO PCT/US2013/054671 patent/WO2014028449A1/en active Application Filing
- 2013-08-13 CN CN201380043534.6A patent/CN104582612B/zh active Active
- 2013-08-13 CA CA2882284A patent/CA2882284C/en active Active
- 2013-08-13 EP EP17190752.0A patent/EP3308727B1/en active Active
- 2013-08-13 IN IN1068DEN2015 patent/IN2015DN01068A/en unknown
- 2013-08-13 KR KR1020157006058A patent/KR102191658B1/ko active IP Right Grant
- 2013-08-13 BR BR112015003305-9A patent/BR112015003305B1/pt not_active IP Right Cessation
- 2013-08-14 TW TW102129084A patent/TWI613991B/zh not_active IP Right Cessation
-
2016
- 2016-06-06 US US15/174,054 patent/US9833271B2/en active Active
-
2017
- 2017-11-10 US US15/808,932 patent/US10226293B2/en active Active
-
2019
- 2019-02-04 US US16/266,302 patent/US11039870B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10226293B2 (en) | 2019-03-12 |
IN2015DN01068A (pt) | 2015-06-26 |
US20160278831A1 (en) | 2016-09-29 |
WO2014028449A1 (en) | 2014-02-20 |
CN104582612A (zh) | 2015-04-29 |
TW201427638A (zh) | 2014-07-16 |
US20190167325A1 (en) | 2019-06-06 |
US20140052060A1 (en) | 2014-02-20 |
JP6312677B2 (ja) | 2018-04-18 |
US9833271B2 (en) | 2017-12-05 |
TWI613991B (zh) | 2018-02-11 |
CA2882284A1 (en) | 2014-02-20 |
EP2884927A1 (en) | 2015-06-24 |
BR112015003305B1 (pt) | 2021-12-21 |
EP2884927B1 (en) | 2017-09-27 |
JP2015530904A (ja) | 2015-10-29 |
EP3308727B1 (en) | 2020-07-22 |
CA2882284C (en) | 2020-12-15 |
EP3308727A1 (en) | 2018-04-18 |
US9364273B2 (en) | 2016-06-14 |
US20180070998A1 (en) | 2018-03-15 |
KR20150043385A (ko) | 2015-04-22 |
KR102191658B1 (ko) | 2020-12-18 |
CN104582612B (zh) | 2019-07-05 |
US11039870B2 (en) | 2021-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
|
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/08/2013, OBSERVADAS AS CONDICOES LEGAIS. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 11A ANUIDADE. |