BR112015003305A2 - parafuso cirúrgico de elução de fármaco - Google Patents

parafuso cirúrgico de elução de fármaco

Info

Publication number
BR112015003305A2
BR112015003305A2 BR112015003305A BR112015003305A BR112015003305A2 BR 112015003305 A2 BR112015003305 A2 BR 112015003305A2 BR 112015003305 A BR112015003305 A BR 112015003305A BR 112015003305 A BR112015003305 A BR 112015003305A BR 112015003305 A2 BR112015003305 A2 BR 112015003305A2
Authority
BR
Brazil
Prior art keywords
drug eluting
surgical screw
actuator
drug
drive recess
Prior art date
Application number
BR112015003305A
Other languages
English (en)
Other versions
BR112015003305B1 (pt
Inventor
Pandey Anurag
armbruster David
Original Assignee
Synthes Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthes Gmbh filed Critical Synthes Gmbh
Publication of BR112015003305A2 publication Critical patent/BR112015003305A2/pt
Publication of BR112015003305B1 publication Critical patent/BR112015003305B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8605—Heads, i.e. proximal ends projecting from bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8605—Heads, i.e. proximal ends projecting from bone
    • A61B17/861—Heads, i.e. proximal ends projecting from bone specially shaped for gripping driver
    • A61B17/8615—Heads, i.e. proximal ends projecting from bone specially shaped for gripping driver at the central region of the screw head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/866—Material or manufacture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8685—Pins or screws or threaded wires; nuts therefor comprising multiple separate parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00889—Material properties antimicrobial, disinfectant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00893—Material properties pharmaceutically effective
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B2017/561—Implants with special means for releasing a drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)

Abstract

resumo patente de invenção: "parafuso cirúrgico de elução de fármaco". a presente invenção fornece um parafuso cirúrgico de elução de fármaco e um método de fabricação de um parafuso cirúrgico de elução de fármaco. o parafuso cirúrgico de elução de fármaco pode incluir uma haste que tem uma porção rosqueada, uma cabeça que tem uma reentrância de acionamento disposta em uma extremidade proximal da haste, tendo a reentrância de acionamento uma região de reservatório e uma região de engate do acionador e pelo menos um ou mais componentes de elução de fármacos dispostos dentro da região de reservatório da reentrância de acionamento de um modo que não prejudica consideravelmente uma conexão entre um acionador e o parafuso cirúrgico, quando o acionador está disposto operacionalmente dentro da região de engate do acionador, cada um dos pelo menos um ou mais componentes de elução de fármacos incluindo uma matriz carreadora e um agente terapêutico, sendo que o agente terapêutico representa ao menos 20%, em peso, do componente de elução de fármaco antes de qualquer implantação do parafuso cirúrgico de elução de fármaco. 1/1
BR112015003305-9A 2012-08-15 2013-08-13 Parafuso cirúrgico de elução de fármaco BR112015003305B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261683262P 2012-08-15 2012-08-15
US61/683,262 2012-08-15
PCT/US2013/054671 WO2014028449A1 (en) 2012-08-15 2013-08-13 Drug eluting surgical screw

Publications (2)

Publication Number Publication Date
BR112015003305A2 true BR112015003305A2 (pt) 2017-07-04
BR112015003305B1 BR112015003305B1 (pt) 2021-12-21

Family

ID=49004048

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015003305-9A BR112015003305B1 (pt) 2012-08-15 2013-08-13 Parafuso cirúrgico de elução de fármaco

Country Status (10)

Country Link
US (4) US9364273B2 (pt)
EP (2) EP2884927B1 (pt)
JP (1) JP6312677B2 (pt)
KR (1) KR102191658B1 (pt)
CN (1) CN104582612B (pt)
BR (1) BR112015003305B1 (pt)
CA (1) CA2882284C (pt)
IN (1) IN2015DN01068A (pt)
TW (1) TWI613991B (pt)
WO (1) WO2014028449A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364273B2 (en) 2012-08-15 2016-06-14 DePuy Synthes Products, Inc. Drug eluting surgical screw
US10537373B2 (en) * 2015-04-24 2020-01-21 Biomet Sports Medicine, Llc Porous implants with injectable capabilities
WO2017146627A1 (en) * 2016-02-26 2017-08-31 Neuronano Ab Method of implantation of cell aggregates and tissue fragments
WO2017150535A1 (ja) * 2016-02-29 2017-09-08 メドトロニックソファモアダネック株式会社 抗菌性生体内埋込用器具用セットスクリュー
KR20240015057A (ko) * 2021-01-15 2024-02-02 디퓨전 알엑스 인코포레이티드 치료제를 지속적이고 연속적으로 방출하는 조인트 임플란트

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4476590A (en) * 1980-03-27 1984-10-16 National Research Development Corporation Antimicrobial surgical implants
JPS5770816A (en) * 1980-10-17 1982-05-01 Ono Pharmaceut Co Ltd Multilayered film preparation of prostagladin of prolonged action
US4905680A (en) * 1986-10-27 1990-03-06 Johnson & Johnson Orthopaedics, Inc. Absorbable bone plate
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US5985317A (en) * 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
TW402930U (en) * 1999-02-12 2000-08-21 Yang Je Jung Improvement of marrow internal nail structure
EP1330270A2 (en) * 2000-11-03 2003-07-30 Control Delivery Systems, Inc. Sustained release device for treating conditions of the joint
US20050203612A1 (en) * 2000-12-22 2005-09-15 Avantec Vascular Corporation Devices delivering therapeutic agents and methods regarding the same
US7235079B2 (en) * 2004-11-18 2007-06-26 Acumed Llc Composite bone fasteners
CN1326577C (zh) * 2002-02-28 2007-07-18 诺瓦提斯公司 N－{5－[4－(4－甲基－哌嗪－1－基甲基)－苯甲酰氨基]－2－甲基苯基}－4－(3－吡啶基)－2－嘧啶－胺涂层的支架
US7220755B2 (en) * 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
US20070053963A1 (en) * 2004-01-13 2007-03-08 Hotchkiss Robert N Drug delivery to a joint
US20050250838A1 (en) * 2004-05-04 2005-11-10 Challapalli Prasad V Formulation for sustained delivery
US8535357B2 (en) * 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
US8273086B2 (en) * 2005-03-24 2012-09-25 Depuy Spine, Inc. Low profile spinal tethering devices
US9247973B2 (en) * 2007-09-28 2016-02-02 DePuy Synthes Products, Inc. Anti-microbial implant
US20090163919A1 (en) 2007-12-19 2009-06-25 Peter Tarcha Devices, systems, and methods for delivery of a pharmaceutical to a subject's spine
US8475505B2 (en) * 2008-08-13 2013-07-02 Smed-Ta/Td, Llc Orthopaedic screws
US20100249783A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Drug-eluting implant cover
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US9211175B2 (en) * 2010-07-08 2015-12-15 Covidien Lp Self-detachable medical devices
US20120109111A1 (en) * 2010-10-29 2012-05-03 Empire Technology Development Llc Fenestration system
US9364273B2 (en) 2012-08-15 2016-06-14 DePuy Synthes Products, Inc. Drug eluting surgical screw
US10307194B2 (en) * 2017-08-01 2019-06-04 Warsaw Orthopedic, Inc. Spinal implant and method of manufacture

Also Published As

Publication number Publication date
US20140052060A1 (en) 2014-02-20
US9364273B2 (en) 2016-06-14
US10226293B2 (en) 2019-03-12
WO2014028449A1 (en) 2014-02-20
US11039870B2 (en) 2021-06-22
CA2882284A1 (en) 2014-02-20
EP2884927A1 (en) 2015-06-24
BR112015003305B1 (pt) 2021-12-21
TW201427638A (zh) 2014-07-16
US9833271B2 (en) 2017-12-05
CN104582612A (zh) 2015-04-29
IN2015DN01068A (pt) 2015-06-26
CN104582612B (zh) 2019-07-05
KR102191658B1 (ko) 2020-12-18
TWI613991B (zh) 2018-02-11
JP2015530904A (ja) 2015-10-29
KR20150043385A (ko) 2015-04-22
EP2884927B1 (en) 2017-09-27
EP3308727A1 (en) 2018-04-18
US20190167325A1 (en) 2019-06-06
EP3308727B1 (en) 2020-07-22
CA2882284C (en) 2020-12-15
JP6312677B2 (ja) 2018-04-18
US20180070998A1 (en) 2018-03-15
US20160278831A1 (en) 2016-09-29

Similar Documents

Publication Publication Date Title
BR112015003305A2 (pt) parafuso cirúrgico de elução de fármaco
BR112013010021A2 (pt) combinações farmacêuticas para o tratamento de distúrbios metabólicos.
BR112015025481A2 (pt) parafuso de intervenção de arquitetura aberta
BR112015003734A2 (pt) sistema de fixação óssea
BR122021018243A8 (pt) Composição tópica de baixo ph e método para aumentar a aplicação tópica de um ingrediente ativo cosmeticamente aceitável
BR112017028132A2 (pt) métodos de tratamento de malignidade hematológica usando terapia combinada de inibidor de mtor em nanopartícula
BR112014032663A2 (pt) dispositivo para fixação óssea com ângulo variável
BR112016002465A2 (pt) terapia da combinação para o tratamento de câncer
BR112015006582A2 (pt) fonte de alimentação articulável para dispositivo médico de infusão
BR112015027282A8 (pt) formulação líquida e kit compreendendo fenfluramina, e usos da mesma no tratamento de síndrome de dravet
BRPI1009863B8 (pt) conjunto de cânula
BRPI1011031A2 (pt) sal de arginina de um agente ativo, composição líquida ou em gel farmaceuticamente aceitável, kit, método para tratamento de uma desordem neurológica e método para tratar ou amenizar a doença de parkinson em um paciente que necessite deste.
BR112012010534A2 (pt) "dispositivo de fornecimento de fármaco e método de montagem"
BR112015021446A2 (pt) métodos cirúrgicos empregando composições de peptídeo amfifílico purificado
BR112015028124A2 (pt) formulação estabilizada de pemetrexed
BR112015022650A8 (pt) inibidores de quinase induzível por sal macrocíclico.
BR112015022465A2 (pt) método para tratamento não-tóxico para síndrome de abstinência de drogas
BR112015022896A2 (pt) drogas de alta penetração e suas composições para o tratamento de doenças de parkinson
BR112015017525A2 (pt) peptídeo modificado, sal de um peptídeo modificado, medicamento, e, métodos para tratar ou aliviar uma doença cardiovascular e para produzir um peptídeo modificado
BR112014027884A2 (pt) combinações farmacêuticas para tratamento de distúrbios metabólicos
BR112015022130A8 (pt) dispositivo de redução de volume pulmonar
BR112016013961A2 (pt) angiotensina ii sozinha ou em combinação para o tratamento da hipotensão
BR112015011213A2 (pt) Composto, composição farmacêutica, método de prevenção ou tratamento de um distúrbio ou doença de controle respiratório em um indivíduo, método de prevenção de desestabilização ou de estabilização do ritmo respiratório em um indivíduo, método de preparação de o,n-dimetil-n-[4-(n-propilamina)-6-(prop-2-inilamina)-[1,3,5]triazin-2-il]-hidroxilamina, e composição.
BRPI0817876B8 (pt) aparelho para controlar um fluxo de espermas em um tubo uterino.
BR112013024034A2 (pt) composição farmacêutica para tratamento de doença na cavidade oral compreendendo rebamipida

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/08/2013, OBSERVADAS AS CONDICOES LEGAIS.