BR112012030633A2 - antituberculosis agents - Google Patents

antituberculosis agents

Info

Publication number
BR112012030633A2
BR112012030633A2 BR112012030633A BR112012030633A BR112012030633A2 BR 112012030633 A2 BR112012030633 A2 BR 112012030633A2 BR 112012030633 A BR112012030633 A BR 112012030633A BR 112012030633 A BR112012030633 A BR 112012030633A BR 112012030633 A2 BR112012030633 A2 BR 112012030633A2
Authority
BR
Brazil
Prior art keywords
antituberculosis
alkyl
antituberculosis agents
tetrahydropyrimidine
agents
Prior art date
Application number
BR112012030633A
Other languages
Portuguese (pt)
Inventor
Anamik Kantilal Shah
Dhiman Sarkar
Evans Cliffton Coutinho
Raghuvir Ramakant Pissurlenkar
Rohit Ramesh Joshi
Sampa Sarkar
Vijay Murlidhar Khedkar
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Publication of BR112012030633A2 publication Critical patent/BR112012030633A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

agentes antituberculosos. a presente invenção descreve compostos antituberculose selecionados a partir de tetrahidropirimidina/derivados tetrahidropirimidina de fórmula 1 e seus sais farmaceuticamente aceitáveis para o tratamento de mico bactéria na fase latente, em que r é h, halogênio, di-halogênio, o-alquila, di-o-alquila, r1 é fenila, clorofenila, nitrofenila, diclorofenil, cicloalquila de preferência ciclo-hexila, x é o ou s.antituberculosis agents. The present invention describes antituberculosis compounds selected from tetrahydropyrimidine / tetrahydropyrimidine derivatives of formula 1 and their pharmaceutically acceptable salts for the treatment of mycobacteria in the latent phase, wherein r is h, halogen, dihalogen, o-alkyl, di- o-alkyl, R1 is phenyl, chlorophenyl, nitrophenyl, dichlorophenyl, cycloalkyl preferably cyclohexyl, x is o or s.

BR112012030633A 2010-05-31 2011-05-31 antituberculosis agents BR112012030633A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1244DE2010 2010-05-31
PCT/IB2011/001184 WO2011151701A1 (en) 2010-05-31 2011-05-31 6 - methyl - 4 - phenyl - 5 - ( phenyl or cycloalkyl) carbamoyl - 1,2,3, 4 - tetrahydropyrimidin- 2 - one derivatives as antitubercular agents

Publications (1)

Publication Number Publication Date
BR112012030633A2 true BR112012030633A2 (en) 2016-08-16

Family

ID=44532948

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012030633A BR112012030633A2 (en) 2010-05-31 2011-05-31 antituberculosis agents

Country Status (5)

Country Link
CN (1) CN102971301B (en)
BR (1) BR112012030633A2 (en)
RU (1) RU2590163C2 (en)
WO (1) WO2011151701A1 (en)
ZA (1) ZA201209026B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2961847B1 (en) * 2013-02-27 2019-09-04 Council of Scientific & Industrial Research Nitrite-reductase (nirb) as potential anti-tubercular target and a method to detect the severity of tuberculosis disease
KR101656662B1 (en) * 2014-11-18 2016-09-12 한국생명공학연구원 Pharmaceutical composition containing 2-Oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide derivatives for prevention or treatment of metabolic disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2141322C1 (en) * 1997-08-12 1999-11-20 Голощапов Николай Михайлович Immunomodulating agent "izofon" showing antimycobacterial activity, method of its preparing and using
US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
WO2007101213A2 (en) * 2006-02-28 2007-09-07 Kalypsys, Inc. Novel 2-oxo-1,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidazolidine-2,4-diones useful as inducible nitric oxide synthase inhibitors

Also Published As

Publication number Publication date
RU2590163C2 (en) 2016-07-10
WO2011151701A1 (en) 2011-12-08
CN102971301B (en) 2015-07-22
CN102971301A (en) 2013-03-13
ZA201209026B (en) 2013-07-31
RU2012154338A (en) 2014-07-20

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL