BR112012028964A2 - quinazolinas policíclicas, método de preparação das mesmas e seus usos - Google Patents
quinazolinas policíclicas, método de preparação das mesmas e seus usosInfo
- Publication number
- BR112012028964A2 BR112012028964A2 BR112012028964A BR112012028964A BR112012028964A2 BR 112012028964 A2 BR112012028964 A2 BR 112012028964A2 BR 112012028964 A BR112012028964 A BR 112012028964A BR 112012028964 A BR112012028964 A BR 112012028964A BR 112012028964 A2 BR112012028964 A2 BR 112012028964A2
- Authority
- BR
- Brazil
- Prior art keywords
- quinazolines
- polycyclic
- preparation
- polycyclic quinazolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010182895 | 2010-05-21 | ||
| PCT/CN2011/074434 WO2011144059A1 (zh) | 2010-05-21 | 2011-05-20 | 一种稠环喹唑啉类衍生物及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012028964A2 true BR112012028964A2 (pt) | 2016-07-26 |
Family
ID=44972984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012028964A BR112012028964A2 (pt) | 2010-05-21 | 2011-05-20 | quinazolinas policíclicas, método de preparação das mesmas e seus usos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110288086A1 (pt) |
| EP (1) | EP2592083A4 (pt) |
| JP (1) | JP2013526590A (pt) |
| KR (1) | KR20130045275A (pt) |
| CN (1) | CN102918044A (pt) |
| AU (1) | AU2011255169A1 (pt) |
| BR (1) | BR112012028964A2 (pt) |
| CA (1) | CA2799989A1 (pt) |
| MX (1) | MX2012013527A (pt) |
| RU (1) | RU2012147319A (pt) |
| WO (1) | WO2011144059A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013159698A1 (zh) * | 2012-04-26 | 2013-10-31 | 深圳信立泰药业股份有限公司 | 稠环喹唑啉羟肟酸类化合物及其作为抗肿瘤药物的应用 |
| CN106518879B (zh) * | 2016-09-21 | 2018-12-07 | 西安交通大学 | 一类2,3-内酰胺环稠合喹唑啉-4(3h)-酮衍生物及其制备方法和应用 |
| CN106928069B (zh) * | 2017-03-21 | 2019-03-19 | 上海玉函化工有限公司 | 一种4,5-二(2-甲氧基乙氧基)-2-硝基苯甲酸乙酯的制备方法 |
| CN108358798A (zh) * | 2018-02-12 | 2018-08-03 | 黑龙江鑫创生物科技开发有限公司 | 一种微通道反应器合成厄洛替尼中间体的方法 |
| CN113603650B (zh) * | 2021-08-03 | 2023-03-10 | 杭州职业技术学院 | 一种埃罗替尼关键中间体的催化环合制备方法及其应用 |
| TW202315625A (zh) * | 2021-08-13 | 2023-04-16 | 大陸商深圳信立泰藥業股份有限公司 | 三聯吡啶二酮化合物或其鹽、包括其藥物組合物及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0817775T3 (da) | 1995-03-30 | 2001-11-19 | Pfizer | Quinazolinderivater |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| CA2258548C (en) * | 1996-06-24 | 2005-07-26 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
| TR199900636T2 (xx) * | 1996-09-23 | 1999-10-21 | Rutgers, The State University Of New Jersey | Anti-t�m�r ajanlar� olarak ikameli/katk�l� heterosayk�llar. |
| US7262297B2 (en) * | 2003-05-15 | 2007-08-28 | Hoffmann-La Roche Inc. | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors |
| JP4533391B2 (ja) | 2004-01-16 | 2010-09-01 | エフ．ホフマン−ラ ロシュ アーゲー | 中枢神経系疾患の処置のための５−ヒドロキシトリプタミンレセプター（５−ｈｔ）のモジュレーターとしての、１−ベンジル−５−ピペラジン−１−イル−３，４−ジヒドロ−１ｈ−キナゾリン−２−オン誘導体、ならびにそれぞれの１ｈ−ベンゾ（１，２，６）チアジアジン−２，２−ジオキシドおよび１，４−ジヒドロベンゾ（ｄ）（１，３）オキサジン−２−オン誘導体 |
| GB0601215D0 (en) | 2006-01-21 | 2006-03-01 | Astrazeneca Ab | Chemical compounds |
| EP2014651A1 (en) * | 2007-07-12 | 2009-01-14 | Exonhit Therapeutics SA | Compounds and methods for modulating Rho GTPases |
| CN101457251A (zh) * | 2007-12-10 | 2009-06-17 | 浙江大学 | 一种增敏肿瘤细胞药剂的筛选方法及其应用 |
| CN101613356B (zh) * | 2009-07-23 | 2012-07-04 | 东南大学 | 喹唑啉类四环衍生物及制备方法和在制药中的应用 |
-
2011
- 2011-05-20 JP JP2013511520A patent/JP2013526590A/ja active Pending
- 2011-05-20 KR KR1020127033456A patent/KR20130045275A/ko not_active Application Discontinuation
- 2011-05-20 CN CN2011800261684A patent/CN102918044A/zh active Pending
- 2011-05-20 BR BR112012028964A patent/BR112012028964A2/pt not_active IP Right Cessation
- 2011-05-20 RU RU2012147319/04A patent/RU2012147319A/ru not_active Application Discontinuation
- 2011-05-20 WO PCT/CN2011/074434 patent/WO2011144059A1/zh active Application Filing
- 2011-05-20 US US13/112,354 patent/US20110288086A1/en not_active Abandoned
- 2011-05-20 CA CA2799989A patent/CA2799989A1/en not_active Abandoned
- 2011-05-20 AU AU2011255169A patent/AU2011255169A1/en not_active Abandoned
- 2011-05-20 EP EP11782976.2A patent/EP2592083A4/en not_active Withdrawn
- 2011-05-20 MX MX2012013527A patent/MX2012013527A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011144059A1 (zh) | 2011-11-24 |
| KR20130045275A (ko) | 2013-05-03 |
| EP2592083A1 (en) | 2013-05-15 |
| JP2013526590A (ja) | 2013-06-24 |
| CN102918044A (zh) | 2013-02-06 |
| CA2799989A1 (en) | 2011-11-24 |
| EP2592083A4 (en) | 2014-01-22 |
| MX2012013527A (es) | 2013-04-08 |
| US20110288086A1 (en) | 2011-11-24 |
| AU2011255169A1 (en) | 2013-01-17 |
| RU2012147319A (ru) | 2014-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |