BR112012010149A2 - composto de paclitaxel / esteroidal - Google Patents
composto de paclitaxel / esteroidalInfo
- Publication number
- BR112012010149A2 BR112012010149A2 BR112012010149-8A BR112012010149A BR112012010149A2 BR 112012010149 A2 BR112012010149 A2 BR 112012010149A2 BR 112012010149 A BR112012010149 A BR 112012010149A BR 112012010149 A2 BR112012010149 A2 BR 112012010149A2
- Authority
- BR
- Brazil
- Prior art keywords
- paclitaxel
- steroid
- steroid compound
- disclosed
- emulsion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910236960.7A CN102048725B (zh) | 2009-10-29 | 2009-10-29 | 紫杉醇胆固醇复合物 |
| CN2009102369607 | 2009-10-29 | ||
| PCT/CN2010/078202 WO2011050735A1 (zh) | 2009-10-29 | 2010-10-28 | 紫杉醇/类固醇复合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012010149A2 true BR112012010149A2 (pt) | 2018-03-20 |
Family
ID=43921347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012010149-8A BR112012010149A2 (pt) | 2009-10-29 | 2010-10-28 | composto de paclitaxel / esteroidal |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20130150335A1 (https=) |
| EP (1) | EP2494956A4 (https=) |
| JP (1) | JP6158513B2 (https=) |
| KR (1) | KR20120091258A (https=) |
| CN (2) | CN102048725B (https=) |
| AU (1) | AU2010312017B2 (https=) |
| BR (1) | BR112012010149A2 (https=) |
| CA (1) | CA2779316C (https=) |
| WO (1) | WO2011050735A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048688B (zh) * | 2009-10-29 | 2014-03-05 | 中国医学科学院药物研究所 | 以胆固醇复合物为中间载体的紫杉醇亚微乳 |
| EP2679225A1 (de) * | 2012-06-26 | 2014-01-01 | Universitätsklinikum Freiburg | Pharmazeutische Zusammensetzung mit synergistischer Wirkung von direkten Katalaseinhibitoren und zur Katalasezerstörung führenden Modulatoren des NO-Stoffwechsels oder der extrazellulären Superoxidanionenproduktion |
| US11273105B2 (en) * | 2017-06-16 | 2022-03-15 | Sorse Technology Corporation | Method for preparing solid forms of plant extract |
| CN108272747B (zh) * | 2018-03-16 | 2020-02-18 | 武汉百纳礼康生物制药有限公司 | 一种非那雄胺溶致液晶凝胶制剂前体及其制备方法 |
| KR20210078505A (ko) | 2018-10-16 | 2021-06-28 | 유에스 나노 푸드 앤 드럭 인코포레이티드 | 종양내 주사 제형 |
| WO2021211294A1 (en) | 2020-04-13 | 2021-10-21 | US Nano Food & Drug INC | Basic chemotherapeutic intratumour injection formulation |
| KR102789632B1 (ko) * | 2021-04-01 | 2025-04-01 | 에스엔제이 파마 인크 | 생활성물질의 경구용 나노입자 및 이의 제조방법 |
| CN115177589B (zh) * | 2021-04-07 | 2024-02-06 | 中国医学科学院药物研究所 | 一种紫杉醇脑靶向脂质体和其制备方法及应用 |
| CN115463110B (zh) * | 2021-06-10 | 2023-12-15 | 中国医学科学院药物研究所 | 一种胆酸修饰的口服紫杉醇纳米粒、其制备方法及应用 |
| CN115737654B (zh) * | 2021-09-03 | 2025-11-21 | 成都瑞沐生物医药科技有限公司 | 一种滴眼给药预防和/或治疗白内障的眼用制剂 |
| CN116196283A (zh) * | 2021-11-30 | 2023-06-02 | 深圳玖星制药有限公司 | 一种注射用紫杉烷类药物脂质体冻干粉剂的制备方法及原料组方 |
| CN117482052A (zh) * | 2023-11-29 | 2024-02-02 | 中国药科大学 | 一种口服紫杉醇三元递药系统及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5616330A (en) * | 1994-07-19 | 1997-04-01 | Hemagen/Pfc | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same |
| US5827533A (en) * | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| CN1116875C (zh) * | 2000-10-19 | 2003-08-06 | 南京振中生物工程有限公司 | 紫杉醇脂质组合物及其制备方法 |
| US20090110739A1 (en) * | 2007-05-15 | 2009-04-30 | University Of North Texas Health Science Center At Forth Worth | Targeted cancer chemotherapy using synthetic nanoparticles |
| CN101396343B (zh) * | 2007-09-26 | 2011-12-07 | 中国医学科学院药物研究所 | 以脂质复合物为中间载体的紫杉醇亚微乳 |
| CN102048688B (zh) * | 2009-10-29 | 2014-03-05 | 中国医学科学院药物研究所 | 以胆固醇复合物为中间载体的紫杉醇亚微乳 |
-
2009
- 2009-10-29 CN CN200910236960.7A patent/CN102048725B/zh active Active
-
2010
- 2010-10-28 CA CA2779316A patent/CA2779316C/en not_active Expired - Fee Related
- 2010-10-28 EP EP10826098.5A patent/EP2494956A4/en not_active Withdrawn
- 2010-10-28 US US13/505,173 patent/US20130150335A1/en not_active Abandoned
- 2010-10-28 BR BR112012010149-8A patent/BR112012010149A2/pt not_active IP Right Cessation
- 2010-10-28 AU AU2010312017A patent/AU2010312017B2/en not_active Ceased
- 2010-10-28 CN CN201080059671.5A patent/CN102811706B/zh active Active
- 2010-10-28 WO PCT/CN2010/078202 patent/WO2011050735A1/zh not_active Ceased
- 2010-10-28 JP JP2012535616A patent/JP6158513B2/ja active Active
- 2010-10-28 KR KR1020127013922A patent/KR20120091258A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2494956A9 (en) | 2013-04-17 |
| CN102811706A (zh) | 2012-12-05 |
| CN102811706B (zh) | 2015-05-06 |
| AU2010312017B2 (en) | 2014-07-17 |
| JP6158513B2 (ja) | 2017-07-12 |
| CN102048725A (zh) | 2011-05-11 |
| US20130150335A1 (en) | 2013-06-13 |
| KR20120091258A (ko) | 2012-08-17 |
| EP2494956A1 (en) | 2012-09-05 |
| JP2013509360A (ja) | 2013-03-14 |
| WO2011050735A1 (zh) | 2011-05-05 |
| CA2779316C (en) | 2016-05-03 |
| EP2494956A4 (en) | 2013-10-23 |
| HK1179513A1 (zh) | 2013-10-04 |
| CN102048725B (zh) | 2014-07-16 |
| CA2779316A1 (en) | 2011-05-05 |
| AU2010312017A1 (en) | 2012-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2465 DE 03-04-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |