BR112012004836A2 - pirazinilpiridinas úteis para o tratamento de doenças proliferativas - Google Patents
pirazinilpiridinas úteis para o tratamento de doenças proliferativasInfo
- Publication number
- BR112012004836A2 BR112012004836A2 BR112012004836A BR112012004836A BR112012004836A2 BR 112012004836 A2 BR112012004836 A2 BR 112012004836A2 BR 112012004836 A BR112012004836 A BR 112012004836A BR 112012004836 A BR112012004836 A BR 112012004836A BR 112012004836 A2 BR112012004836 A2 BR 112012004836A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrazinylpyridines
- useful
- treatment
- proliferative diseases
- proliferative
- Prior art date
Links
- IUEQMQXAVZARKU-UHFFFAOYSA-N 2-pyridin-2-ylpyrazine Chemical class N1=CC=CC=C1C1=CN=CC=N1 IUEQMQXAVZARKU-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27593809P | 2009-09-04 | 2009-09-04 | |
| US28496209P | 2009-12-28 | 2009-12-28 | |
| PCT/EP2010/062881 WO2011026904A1 (en) | 2009-09-04 | 2010-09-02 | Pyrazinylpyridines useful for the treatment of proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012004836A2 true BR112012004836A2 (pt) | 2019-09-24 |
Family
ID=43480986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012004836A BR112012004836A2 (pt) | 2009-09-04 | 2010-09-02 | pirazinilpiridinas úteis para o tratamento de doenças proliferativas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120165306A1 (enExample) |
| EP (1) | EP2473505A1 (enExample) |
| KR (1) | KR20120076352A (enExample) |
| CN (1) | CN102482265A (enExample) |
| AU (1) | AU2010291199A1 (enExample) |
| BR (1) | BR112012004836A2 (enExample) |
| CA (1) | CA2772265A1 (enExample) |
| IN (1) | IN2012DN01273A (enExample) |
| MX (1) | MX2012002758A (enExample) |
| WO (1) | WO2011026904A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8415381B2 (en) * | 2009-07-30 | 2013-04-09 | Novartis Ag | Heteroaryl compounds and their uses |
| WO2012101064A1 (en) * | 2011-01-28 | 2012-08-02 | Novartis Ag | N-acyl pyrimidine biaryl compounds as protein kinase inhibitors |
| WO2012101062A1 (en) * | 2011-01-28 | 2012-08-02 | Novartis Ag | Substituted bi-heteroaryl compounds as cdk9 inhibitors and their uses |
| WO2014106606A1 (en) * | 2013-01-05 | 2014-07-10 | F. Hoffmann-La Roche Ag | Nove phenyl/pyridine series substitued by hydroxyethylamino for the treatment of cancer |
| HK1223927A1 (en) | 2013-09-12 | 2017-08-11 | Sumitomo Chemical Company, Limited | Nitrogen-containing saturated heterocyclic compound |
| JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| SG11201902523UA (en) | 2016-10-20 | 2019-05-30 | Pfizer | Anti-proliferative agents for treating pah |
| WO2020016579A2 (en) | 2018-07-17 | 2020-01-23 | Gtn Ltd | Machine learning based methods of analysing drug-like molecules |
| CN114787142B (zh) * | 2019-12-09 | 2024-08-02 | 石药集团中奇制药技术（石家庄）有限公司 | 作为周期蛋白依赖性激酶9抑制剂的化合物及其应用 |
| GB202013419D0 (en) | 2020-08-27 | 2020-10-14 | Kuano Ltd | Transition state 2020 |
| WO2022247796A1 (zh) * | 2021-05-24 | 2022-12-01 | 石药集团中奇制药技术（石家庄）有限公司 | 周期蛋白依赖性激酶9抑制剂的用途 |
| WO2022247785A1 (zh) * | 2021-05-24 | 2022-12-01 | 石药集团中奇制药技术（石家庄）有限公司 | 一种周期蛋白依赖性激酶9抑制剂的用途 |
| WO2022257965A1 (zh) * | 2021-06-09 | 2022-12-15 | 石药集团中奇制药技术（石家庄）有限公司 | 固体形式的周期蛋白依赖性激酶9抑制剂及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| DE60136731D1 (de) * | 2000-09-20 | 2009-01-08 | Ortho Mcneil Pharm Inc | Pyrazine derivate als tyrosin kinase modulatoren |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| BRPI0720635A2 (pt) * | 2006-12-22 | 2014-01-07 | Novartis Ag | Compostos orgânicos e seus usos |
-
2010
- 2010-09-02 WO PCT/EP2010/062881 patent/WO2011026904A1/en not_active Ceased
- 2010-09-02 US US13/393,457 patent/US20120165306A1/en not_active Abandoned
- 2010-09-02 CA CA2772265A patent/CA2772265A1/en not_active Abandoned
- 2010-09-02 AU AU2010291199A patent/AU2010291199A1/en not_active Abandoned
- 2010-09-02 EP EP10748097A patent/EP2473505A1/en not_active Withdrawn
- 2010-09-02 MX MX2012002758A patent/MX2012002758A/es not_active Application Discontinuation
- 2010-09-02 KR KR1020127008621A patent/KR20120076352A/ko not_active Withdrawn
- 2010-09-02 BR BR112012004836A patent/BR112012004836A2/pt not_active IP Right Cessation
- 2010-09-02 IN IN1273DEN2012 patent/IN2012DN01273A/en unknown
- 2010-09-02 CN CN2010800392830A patent/CN102482265A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20120165306A1 (en) | 2012-06-28 |
| CA2772265A1 (en) | 2011-03-10 |
| KR20120076352A (ko) | 2012-07-09 |
| WO2011026904A1 (en) | 2011-03-10 |
| IN2012DN01273A (enExample) | 2015-05-15 |
| EP2473505A1 (en) | 2012-07-11 |
| AU2010291199A1 (en) | 2012-03-08 |
| CN102482265A (zh) | 2012-05-30 |
| MX2012002758A (es) | 2012-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |