BR102021006083A2 - LONG-TERM REABSORBABBLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRECONCENTRATELY PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR HYPOTHYROIDISM TREATMENT AND PROCESS - Google Patents

LONG-TERM REABSORBABBLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRECONCENTRATELY PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR HYPOTHYROIDISM TREATMENT AND PROCESS

Info

Publication number
BR102021006083A2
BR102021006083A2 BR102021006083A BR102021006083A BR102021006083A2 BR 102021006083 A2 BR102021006083 A2 BR 102021006083A2 BR 102021006083 A BR102021006083 A BR 102021006083A BR 102021006083 A BR102021006083 A BR 102021006083A BR 102021006083 A2 BR102021006083 A2 BR 102021006083A2
Authority
BR
Brazil
Prior art keywords
implant
hypothyroidism
treatment
active substance
long
Prior art date
Application number
BR102021006083A
Other languages
Portuguese (pt)
Inventor
Luiz Peracchi Edson
Original Assignee
Luiz Peracchi Edson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luiz Peracchi Edson filed Critical Luiz Peracchi Edson
Priority to BR102021006083A priority Critical patent/BR102021006083A2/en
Priority to EP22778223.2A priority patent/EP4316464A1/en
Priority to PCT/BR2022/050110 priority patent/WO2022204771A1/en
Publication of BR102021006083A2 publication Critical patent/BR102021006083A2/en

Links

Abstract

IMPLANTE SUBCUTÂNEO REABSORVÍVEL DE LONGA DURAÇÃO COM LIBERAÇÃO PROLONGADA DE SUBSTÂNCIA FARMACOLOGICAMENTE ATIVA PRÉ CONCENTRADA EM POLÍMERO PARA TRATAMENTO DO HIPOTIREOIDISMO E PROCESSO. O presente pedido de privilégio de invenção é voltado ao setor de saúde e compreende um implante subcutâneo reabsorvível de longa duração com liberação prolongada de substância farmacologicamente ativa pré-concentrada em polímero para tratamento do hipotireoidismo. O presente pedido é um implante biodegradável de triiodotironina (T3) isolada, tiroxina (T4) isolada ou associação de triiodotironina (T3) e tiroxina (T4) para tratamento do hipotireoidismo em matriz polimérica. O implante é inserido por via subcutânea e possui liberação contínua do ativo por um período de tempo prolongado. Essa liberação visa garantir um nível sérico do fármaco eficiente, constante e prolongado para o tratamento do hipotireoidismo. O implante adota o padrão cilíndrico (1), em formato de haste, provido de pontas retas ou arredondadas, com comprimento entre 2 a 25 mm e o diâmetro de 1 a 6 mm. A mistura de ativos para fabricação do implante pode ser moldada a partir da pressão ou do calor, de forma a não comprometer a eficácia da droga nem degradar o material polimérico. As opções de técnicas para moldagem do implante podem ser: moldagem por injeção, moldagem a quente, moldagem por compressão ou moldagem por extrusão.LONG-TERM REABSORBABBLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRE-CONCENTRATELY PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR HYPOTHYROIDISM TREATMENT AND PROCESS. The present invention privilege application is aimed at the health sector and comprises a long-term resorbable subcutaneous implant with prolonged release of a pre-concentrated polymer pharmacologically active substance for the treatment of hypothyroidism. The present application is a biodegradable implant of triiodothyronine (T3) alone, thyroxine (T4) alone or combination of triiodothyronine (T3) and thyroxine (T4) for treating hypothyroidism in polymeric matrix. The implant is inserted subcutaneously and has a continuous release of the active for an extended period of time. This release aims to ensure an efficient, constant and prolonged serum level of the drug for the treatment of hypothyroidism. The implant adopts the cylindrical pattern (1), in the form of a rod, provided with straight or rounded tips, with a length between 2 and 25 mm and a diameter of 1 to 6 mm. The mixture of actives for manufacturing the implant can be molded from pressure or heat, so as not to compromise the drug's effectiveness or degrade the polymeric material. The options for implant molding techniques can be: injection molding, hot molding, compression molding or extrusion molding.

BR102021006083A 2021-03-29 2021-03-29 LONG-TERM REABSORBABBLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRECONCENTRATELY PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR HYPOTHYROIDISM TREATMENT AND PROCESS BR102021006083A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BR102021006083A BR102021006083A2 (en) 2021-03-29 2021-03-29 LONG-TERM REABSORBABBLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRECONCENTRATELY PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR HYPOTHYROIDISM TREATMENT AND PROCESS
EP22778223.2A EP4316464A1 (en) 2021-03-29 2022-03-28 Long-lasting resorbable subcutaneous implant with prolonged release of pre-concentrated pharmacologically active substance in polymer for the treatment of hypothyroidism, and method
PCT/BR2022/050110 WO2022204771A1 (en) 2021-03-29 2022-03-28 Long-lasting resorbable subcutaneous implant with prolonged release of pre-concentrated pharmacologically active substance in polymer for the treatment of hypothyroidism, and method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR102021006083A BR102021006083A2 (en) 2021-03-29 2021-03-29 LONG-TERM REABSORBABBLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRECONCENTRATELY PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR HYPOTHYROIDISM TREATMENT AND PROCESS

Publications (1)

Publication Number Publication Date
BR102021006083A2 true BR102021006083A2 (en) 2022-10-11

Family

ID=83560221

Family Applications (1)

Application Number Title Priority Date Filing Date
BR102021006083A BR102021006083A2 (en) 2021-03-29 2021-03-29 LONG-TERM REABSORBABBLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRECONCENTRATELY PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR HYPOTHYROIDISM TREATMENT AND PROCESS

Country Status (1)

Country Link
BR (1) BR102021006083A2 (en)

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Legal Events

Date Code Title Description
B11K Dismissal acc. art. 17, par 2 of ipl - pending earlier application (priority claim) definitively shelved

Free format text: PRIORIDADE INTERNA: BR 10 2021 014927 2

B03F Publication of an application: publication of application definitely dismissed [chapter 3.6 patent gazette]