BR0316875A - Compostos de pirazol como derivados antagonistas receptores da integrina, sua composição farmacêutica e respectivo uso - Google Patents
Compostos de pirazol como derivados antagonistas receptores da integrina, sua composição farmacêutica e respectivo usoInfo
- Publication number
- BR0316875A BR0316875A BR0316875-1A BR0316875A BR0316875A BR 0316875 A BR0316875 A BR 0316875A BR 0316875 A BR0316875 A BR 0316875A BR 0316875 A BR0316875 A BR 0316875A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- receptor antagonist
- integrin receptor
- pyrazole compounds
- integrin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTOS DE PIRAZOL COMO DERIVADOS ANTAGONISTAS RECEPTORES DA INTEGRINA, SUA COMPOSIçãO FARMACêUTICA E RESPECTIVO USO". A presente invenção refere-se às composições farmacêuticas compreendendo compostos da Fórmula (I), e métodos para seletivamente inibir ou antagonizar a integrina <244>~ v~<225>~ 5~ sem significativamente inibir a integrina <244>~ v~<225~ 6~.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43516802P | 2002-12-20 | 2002-12-20 | |
PCT/US2003/040630 WO2004058761A1 (en) | 2002-12-20 | 2003-12-19 | Pyrazole compounds as integrin receptor antagonists derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0316875A true BR0316875A (pt) | 2005-10-25 |
Family
ID=32682173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0316875-1A BR0316875A (pt) | 2002-12-20 | 2003-12-19 | Compostos de pirazol como derivados antagonistas receptores da integrina, sua composição farmacêutica e respectivo uso |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050004200A1 (pt) |
EP (1) | EP1572691A1 (pt) |
JP (1) | JP2006513218A (pt) |
AU (1) | AU2003297409A1 (pt) |
BR (1) | BR0316875A (pt) |
CA (1) | CA2507958A1 (pt) |
MX (1) | MXPA05006588A (pt) |
WO (1) | WO2004058761A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3929196T (pt) | 2013-09-24 | 2023-09-11 | Fujifilm Corp | Composição farmacêutica de um novo composto contendo azoto ou seu sal, ou seu complexo de metal |
EA038164B1 (ru) | 2016-11-08 | 2021-07-16 | Бристол-Маерс Сквибб Компани | 3-замещенные пропановые кислоты в качестве ингибиторов интегрина v |
BR112019012515A2 (pt) | 2016-12-29 | 2019-11-19 | Saint Louis University | antagonistas de integrina |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
ES2162676T3 (es) * | 1996-03-29 | 2002-01-01 | Searle & Co | Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3. |
ES2179318T3 (es) * | 1996-03-29 | 2003-01-16 | Searle & Co | Derivados de acido cinamico y su uso como antagonistas de integrina. |
JP2004511434A (ja) * | 2000-06-15 | 2004-04-15 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸 |
BR0316876A (pt) * | 2002-12-20 | 2005-10-25 | Pharmacia Corp | Compostos de tiazol e composição farmacêutica compreendendo o mesmo |
-
2003
- 2003-12-19 JP JP2004563834A patent/JP2006513218A/ja active Pending
- 2003-12-19 US US10/741,860 patent/US20050004200A1/en not_active Abandoned
- 2003-12-19 EP EP03814227A patent/EP1572691A1/en not_active Withdrawn
- 2003-12-19 AU AU2003297409A patent/AU2003297409A1/en not_active Abandoned
- 2003-12-19 CA CA002507958A patent/CA2507958A1/en not_active Abandoned
- 2003-12-19 WO PCT/US2003/040630 patent/WO2004058761A1/en active Application Filing
- 2003-12-19 BR BR0316875-1A patent/BR0316875A/pt not_active IP Right Cessation
- 2003-12-19 MX MXPA05006588A patent/MXPA05006588A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1572691A1 (en) | 2005-09-14 |
US20050004200A1 (en) | 2005-01-06 |
JP2006513218A (ja) | 2006-04-20 |
WO2004058761A1 (en) | 2004-07-15 |
MXPA05006588A (es) | 2005-08-16 |
AU2003297409A1 (en) | 2004-07-22 |
CA2507958A1 (en) | 2004-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A., 6A., E 7A. ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |