BR0312614A - N-sulfonilpiperidinas como inibidores de metaloproteinase (tece) - Google Patents
N-sulfonilpiperidinas como inibidores de metaloproteinase (tece)Info
- Publication number
- BR0312614A BR0312614A BR0312614-5A BR0312614A BR0312614A BR 0312614 A BR0312614 A BR 0312614A BR 0312614 A BR0312614 A BR 0312614A BR 0312614 A BR0312614 A BR 0312614A
- Authority
- BR
- Brazil
- Prior art keywords
- sulfonylpiperidines
- weaves
- metalloproteinase inhibitors
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"N-SULPONILPIPERIDINAS COMO INIBIDORES DE METALOPROTEINASE (TACE)". A presente invenção se refere a compostos de fórmula (1), onde Z é -CONR^ 15^ OH ou -N(OH)CHO e X é -(CR^ 9^R^ 10^)~ t~-Q-(CR~ 11^R^ 12^)~ u~, em que t e u são independentemente O ou 1, com a condição de que t e u não possam ser ambos 0. Os compostos da invenção são inibidores de metaloproteinases, em particular, da TACE.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0216379.8A GB0216379D0 (en) | 2002-07-13 | 2002-07-13 | Compounds |
| PCT/GB2003/002959 WO2004006925A1 (en) | 2002-07-13 | 2003-07-09 | N-sulfonylpiperidines as metalloproteinase inhibitors (tace) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312614A true BR0312614A (pt) | 2005-05-10 |
Family
ID=9940460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312614-5A BR0312614A (pt) | 2002-07-13 | 2003-07-09 | N-sulfonilpiperidinas como inibidores de metaloproteinase (tece) |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20060142336A1 (pt) |
| EP (1) | EP1534281A1 (pt) |
| JP (1) | JP2005536501A (pt) |
| CN (1) | CN1681504A (pt) |
| AU (1) | AU2003254436A1 (pt) |
| BR (1) | BR0312614A (pt) |
| CA (1) | CA2492083A1 (pt) |
| GB (1) | GB0216379D0 (pt) |
| IL (1) | IL166009A0 (pt) |
| IS (1) | IS7666A (pt) |
| MX (1) | MXPA05000518A (pt) |
| NO (1) | NO20050765L (pt) |
| PL (1) | PL375304A1 (pt) |
| RU (1) | RU2004138547A (pt) |
| WO (1) | WO2004006925A1 (pt) |
| ZA (1) | ZA200500209B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003022801A1 (fr) | 2001-09-07 | 2003-03-20 | Kaken Pharmaceutical Co., Ltd. | Derives d'acide hydroxamique inverse |
| PL2105164T3 (pl) | 2008-03-25 | 2011-05-31 | Affectis Pharmaceuticals Ag | Nowi antagoniści P2X7R i ich zastosowanie |
| PL2243772T3 (pl) | 2009-04-14 | 2012-05-31 | Affectis Pharmaceuticals Ag | Nowi antagoniści p2x7r i ich zastosowanie |
| WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1087937A1 (en) * | 1998-06-17 | 2001-04-04 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| EP1107953A1 (en) * | 1998-08-29 | 2001-06-20 | British Biotech Pharmaceuticals Limited | Hydroxamic acid derivatives as proteinase inhibitors |
| GB9919776D0 (en) * | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
| BR0007784A (pt) * | 1999-01-27 | 2002-02-05 | American Cyanamid Co | Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto |
-
2002
- 2002-07-13 GB GBGB0216379.8A patent/GB0216379D0/en not_active Ceased
-
2003
- 2003-07-09 CN CNA038216205A patent/CN1681504A/zh active Pending
- 2003-07-09 AU AU2003254436A patent/AU2003254436A1/en not_active Abandoned
- 2003-07-09 MX MXPA05000518A patent/MXPA05000518A/es not_active Application Discontinuation
- 2003-07-09 JP JP2004520828A patent/JP2005536501A/ja active Pending
- 2003-07-09 US US10/521,042 patent/US20060142336A1/en not_active Abandoned
- 2003-07-09 WO PCT/GB2003/002959 patent/WO2004006925A1/en not_active Application Discontinuation
- 2003-07-09 EP EP03763973A patent/EP1534281A1/en not_active Withdrawn
- 2003-07-09 RU RU2004138547/04A patent/RU2004138547A/ru not_active Application Discontinuation
- 2003-07-09 PL PL03375304A patent/PL375304A1/xx not_active Application Discontinuation
- 2003-07-09 CA CA002492083A patent/CA2492083A1/en not_active Abandoned
- 2003-07-09 BR BR0312614-5A patent/BR0312614A/pt not_active Application Discontinuation
-
2004
- 2004-12-27 IL IL16600904A patent/IL166009A0/xx unknown
-
2005
- 2005-01-10 ZA ZA200500209A patent/ZA200500209B/en unknown
- 2005-01-26 IS IS7666A patent/IS7666A/is unknown
- 2005-02-11 NO NO20050765A patent/NO20050765L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL166009A0 (en) | 2006-01-15 |
| PL375304A1 (en) | 2005-11-28 |
| ZA200500209B (en) | 2005-11-02 |
| AU2003254436A1 (en) | 2004-02-02 |
| MXPA05000518A (es) | 2005-03-23 |
| RU2004138547A (ru) | 2005-08-20 |
| WO2004006925A1 (en) | 2004-01-22 |
| US20060142336A1 (en) | 2006-06-29 |
| IS7666A (is) | 2005-01-26 |
| EP1534281A1 (en) | 2005-06-01 |
| CA2492083A1 (en) | 2004-01-22 |
| GB0216379D0 (en) | 2002-08-21 |
| JP2005536501A (ja) | 2005-12-02 |
| NO20050765L (no) | 2005-04-13 |
| CN1681504A (zh) | 2005-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |