BR0312442A - Pró-droga, utilização medicinal desta e processo para produzir a mesma - Google Patents
Pró-droga, utilização medicinal desta e processo para produzir a mesmaInfo
- Publication number
- BR0312442A BR0312442A BR0312442-8A BR0312442A BR0312442A BR 0312442 A BR0312442 A BR 0312442A BR 0312442 A BR0312442 A BR 0312442A BR 0312442 A BR0312442 A BR 0312442A
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme
- drug
- site
- mentioned
- side effects
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PRó-DROGA, UTILIZAçãO MEDICINAL DESTA E PROCESSO PARA PRODUZIR A MESMA". Uma pró-droga utiliza uma enzima cuja atividade enzimática é diferente nos intervalos do sítio alvo da droga e o sítio para expressar efeitos colaterais, a pró-droga tendo um substituinte clivável com a enzima e sendo ativado por clivagem do substituinte com a enzima. Como o sítio alvo da droga, por exemplo, um Orgão respiratório pode ser mencionado e como sítio para expressar efeitos colaterais, por exemplo, o coração pode ser mencionado. Como o exemplo da droga, um broncodilatador pode ser mencionado e como o exemplo da enzima, uma glicosidase (por exemplo, <225>glicuronidase) pode ser mencionada. Além disso, o substituinte é, por exemplo, um grupo glicosila composto de um monossacarídeo ou um oligossacarídeo. O uso da enzima possibilita reduzir os efeitos colaterais de uma droga do tipo cujo sítio alvo é diferente do sítio para expressar efeitos colaterais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002180238 | 2002-06-20 | ||
| PCT/JP2003/007868 WO2004000863A1 (ja) | 2002-06-20 | 2003-06-20 | プロドラッグ、その医薬としての使用、およびその製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312442A true BR0312442A (pt) | 2005-05-10 |
Family
ID=29996599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312442-8A BR0312442A (pt) | 2002-06-20 | 2003-06-20 | Pró-droga, utilização medicinal desta e processo para produzir a mesma |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050203061A1 (pt) |
| EP (1) | EP1541579A1 (pt) |
| JP (1) | JPWO2004000863A1 (pt) |
| KR (1) | KR20050027095A (pt) |
| CN (1) | CN1671724A (pt) |
| AU (1) | AU2003244088A1 (pt) |
| BR (1) | BR0312442A (pt) |
| CA (1) | CA2490626A1 (pt) |
| MX (1) | MXPA05000028A (pt) |
| NZ (1) | NZ537686A (pt) |
| WO (1) | WO2004000863A1 (pt) |
| ZA (1) | ZA200500526B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| AU2008345097A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| CL2009001479A1 (es) * | 2008-07-02 | 2010-01-04 | Infinity Pharmaceuticals Inc | Metodo para aislar un alcaloide del veratrum desglicosilado que comprende proporcionar un material de planta veratrum, poner en contacto con una solucion acuosa y extraer el material de la planta veratrum con un solvente para proporcionar un extracto que comprende dicho alcaloide. |
| ES2567134T3 (es) | 2009-08-05 | 2016-04-20 | Infinity Pharmaceuticals, Inc. | Transaminación enzimática de análogos de ciclopamina |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| JPWO2015005459A1 (ja) * | 2013-07-10 | 2017-03-02 | 生化学工業株式会社 | 呼吸器投与用の医薬組成物 |
| PL3209302T3 (pl) | 2014-10-21 | 2019-10-31 | Abbvie Inc | Proleki karbidopy i L-dopy oraz ich zastosowanie do leczenia choroby Parkinsona |
| JP6796638B2 (ja) | 2015-06-04 | 2020-12-09 | ペレファーム, インク.Pellepharm, Inc. | ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用 |
| MY194058A (en) | 2016-01-11 | 2022-11-10 | Innate Tumor Immunity Inc | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| EP3445346A1 (en) * | 2016-04-20 | 2019-02-27 | AbbVie Inc. | Carbidopa and l-dopa prodrugs and methods of use |
| CN116808243B (zh) * | 2023-08-15 | 2024-04-02 | 上海交通大学 | 苯基-β-D-葡糖苷酸在制备用于诱导式呼气检测肿瘤的药物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9107196D0 (en) * | 1991-04-05 | 1991-05-22 | Sandoz Ag | Improvements in or relating to organic compounds |
| DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| EP0647450A1 (en) * | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| DE69425356T2 (de) * | 1993-09-22 | 2002-04-18 | Hoechst Ag | Pro-Prodrugs, ihre Herstellung und Anwendung |
| US5760072A (en) * | 1995-12-29 | 1998-06-02 | Pharmachemie B.V. | Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy |
| ATE316799T1 (de) * | 1996-03-12 | 2006-02-15 | Sanofi Aventis Deutschland | Neuartige prodrugs für die therapie von tumoren und entzündlichen erkrankungen |
| US6218519B1 (en) * | 1996-04-12 | 2001-04-17 | Pro-Neuron, Inc. | Compounds and methods for the selective treatment of cancer and bacterial infections |
| US5843937A (en) * | 1996-05-23 | 1998-12-01 | Panorama Research, Inc. | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
| US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
| AUPQ342599A0 (en) * | 1999-10-14 | 1999-11-04 | University Of Melbourne, The | Conjugates and uses thereof |
-
2003
- 2003-06-20 JP JP2004515536A patent/JPWO2004000863A1/ja not_active Withdrawn
- 2003-06-20 NZ NZ537686A patent/NZ537686A/en unknown
- 2003-06-20 WO PCT/JP2003/007868 patent/WO2004000863A1/ja not_active Application Discontinuation
- 2003-06-20 US US10/505,961 patent/US20050203061A1/en not_active Abandoned
- 2003-06-20 CA CA002490626A patent/CA2490626A1/en not_active Abandoned
- 2003-06-20 CN CNA038178141A patent/CN1671724A/zh active Pending
- 2003-06-20 MX MXPA05000028A patent/MXPA05000028A/es not_active Application Discontinuation
- 2003-06-20 AU AU2003244088A patent/AU2003244088A1/en not_active Abandoned
- 2003-06-20 EP EP03760921A patent/EP1541579A1/en not_active Withdrawn
- 2003-06-20 KR KR1020047020745A patent/KR20050027095A/ko not_active Application Discontinuation
- 2003-06-20 BR BR0312442-8A patent/BR0312442A/pt not_active IP Right Cessation
-
2005
- 2005-01-19 ZA ZA200500526A patent/ZA200500526B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200500526B (en) | 2006-08-30 |
| US20050203061A1 (en) | 2005-09-15 |
| EP1541579A1 (en) | 2005-06-15 |
| AU2003244088A1 (en) | 2004-01-06 |
| MXPA05000028A (es) | 2005-08-26 |
| CN1671724A (zh) | 2005-09-21 |
| JPWO2004000863A1 (ja) | 2005-10-20 |
| CA2490626A1 (en) | 2003-12-31 |
| KR20050027095A (ko) | 2005-03-17 |
| NZ537686A (en) | 2007-01-26 |
| WO2004000863A1 (ja) | 2003-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Girish et al. | Hyaluronidase inhibitors: a biological and therapeutic perspective | |
| Kunanusornchai et al. | Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: An in vitro and in vivo study | |
| Di Paola et al. | Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats | |
| Kirwan et al. | 8 Intra-articular therapy in osteoarthritis | |
| BR0312442A (pt) | Pró-droga, utilização medicinal desta e processo para produzir a mesma | |
| BR0010564A (pt) | Compostos antitumor ativados por fap | |
| US8575130B2 (en) | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease | |
| BR0313694A (pt) | Derivados de pirazol, composição medicinal contendo os mesmos, seu uso medicinal e intermediários para sua produção | |
| BRPI0413930A (pt) | composto oligomérico ou sal farmaceuticamente aceitável deste, composição farmacêutica ou veterinária, métodos para inibir a expressão de eif4e em uma célula, tecido ou órgão, para diminuir a proliferação de uma célula em que eif4e é expressado, e para prevenir ou tratar uma condição ou doença métodos para prevenir ou diminuir a angiogênese, e o crescimento de tumor em um paciente, oligonucleotìdeo de anti-sentido, composição farmacêutica ou veterinária, e, uso de um composto oligomérico ou sal farmaceuticamente aceitável deste | |
| BR0108173A (pt) | Composições farmacêuticas de toxina de botulina | |
| HUP0301749A2 (hu) | Acilfenil-karbamid-származékok, eljárás az elżállításukra és gyógyszerkénti alkalmazásuk | |
| BRPI0606817A2 (pt) | derivados de piridazina e seu uso como agentes terapêuticos | |
| BRPI9909908B8 (pt) | conjugados de ácido graxo de sal ou ácido biliar, composição farmacêutica compreendendo os mesmos e seus usos | |
| BR0109323A (pt) | Derivados de gluco piranosiloxi benzil benzeno, composições medicinais contendo os mesmos e intermediários para a preparação dos derivados | |
| BRPI0407757A (pt) | derivados de benzamida tetracìclica e métodos de uso dos mesmos | |
| ATE371665T1 (de) | Zuckerderivate von hydromorphon, dihydromorphin und dihydroisomorphin, zusammensetzungen davon und verwendung zur vorbeugung und behandlung von schmerzen | |
| AU2001248301A1 (en) | Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin | |
| Agarwal et al. | Synthesis and biological evaluation of fatty acyl ester derivatives of 2′, 3′-didehydro-2′, 3′-dideoxythymidine | |
| AU2010212350B2 (en) | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease | |
| KR20080035997A (ko) | 글루코사민 또는 글루코사민 유도체를 포함하는 아토피성피부염 치료용 조성물 및 이를 사용하여 아토피성 피부염을치료하는 방법 | |
| BR0014765A (pt) | Sìntese e métodos de uso de derivados de guanina 9-substituìdos | |
| ES2355329T3 (es) | Utilización de polímeros biocompatibles para la preparación de una composición o de un dispositivo medicinal. | |
| Pedowitz et al. | Nerve function and structure beneath and distal to a pneumatic tourniquet applied to rabbit hindlimbs | |
| ES2558881T3 (es) | Polímeros biocompatibles para una composición médica | |
| ITMI941974A1 (it) | Composizioni terapeutiche di condroitin solfato sotto forma di gel somministrabile per via orale |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |