BR0312442A - Pró-droga, utilização medicinal desta e processo para produzir a mesma - Google Patents
Pró-droga, utilização medicinal desta e processo para produzir a mesmaInfo
- Publication number
- BR0312442A BR0312442A BR0312442-8A BR0312442A BR0312442A BR 0312442 A BR0312442 A BR 0312442A BR 0312442 A BR0312442 A BR 0312442A BR 0312442 A BR0312442 A BR 0312442A
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme
- drug
- site
- mentioned
- side effects
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PRó-DROGA, UTILIZAçãO MEDICINAL DESTA E PROCESSO PARA PRODUZIR A MESMA". Uma pró-droga utiliza uma enzima cuja atividade enzimática é diferente nos intervalos do sítio alvo da droga e o sítio para expressar efeitos colaterais, a pró-droga tendo um substituinte clivável com a enzima e sendo ativado por clivagem do substituinte com a enzima. Como o sítio alvo da droga, por exemplo, um Orgão respiratório pode ser mencionado e como sítio para expressar efeitos colaterais, por exemplo, o coração pode ser mencionado. Como o exemplo da droga, um broncodilatador pode ser mencionado e como o exemplo da enzima, uma glicosidase (por exemplo, <225>glicuronidase) pode ser mencionada. Além disso, o substituinte é, por exemplo, um grupo glicosila composto de um monossacarídeo ou um oligossacarídeo. O uso da enzima possibilita reduzir os efeitos colaterais de uma droga do tipo cujo sítio alvo é diferente do sítio para expressar efeitos colaterais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002180238 | 2002-06-20 | ||
| PCT/JP2003/007868 WO2004000863A1 (ja) | 2002-06-20 | 2003-06-20 | プロドラッグ、その医薬としての使用、およびその製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312442A true BR0312442A (pt) | 2005-05-10 |
Family
ID=29996599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312442-8A BR0312442A (pt) | 2002-06-20 | 2003-06-20 | Pró-droga, utilização medicinal desta e processo para produzir a mesma |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050203061A1 (pt) |
| EP (1) | EP1541579A1 (pt) |
| JP (1) | JPWO2004000863A1 (pt) |
| KR (1) | KR20050027095A (pt) |
| CN (1) | CN1671724A (pt) |
| AU (1) | AU2003244088A1 (pt) |
| BR (1) | BR0312442A (pt) |
| CA (1) | CA2490626A1 (pt) |
| MX (1) | MXPA05000028A (pt) |
| NZ (1) | NZ537686A (pt) |
| WO (1) | WO2004000863A1 (pt) |
| ZA (1) | ZA200500526B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| AU2008345097A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| CL2009001479A1 (es) * | 2008-07-02 | 2010-01-04 | Infinity Pharmaceuticals Inc | Metodo para aislar un alcaloide del veratrum desglicosilado que comprende proporcionar un material de planta veratrum, poner en contacto con una solucion acuosa y extraer el material de la planta veratrum con un solvente para proporcionar un extracto que comprende dicho alcaloide. |
| WO2011017551A1 (en) | 2009-08-05 | 2011-02-10 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| WO2015005459A1 (ja) * | 2013-07-10 | 2015-01-15 | 生化学工業株式会社 | 呼吸器投与用の医薬組成物 |
| TWI755257B (zh) | 2014-10-21 | 2022-02-11 | 美商艾伯維有限公司 | 卡比多巴及左旋多巴之前藥及使用方法 |
| CA2988289C (en) | 2015-06-04 | 2023-12-05 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
| MY194058A (en) | 2016-01-11 | 2022-11-10 | Innate Tumor Immunity Inc | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| JP2019515908A (ja) * | 2016-04-20 | 2019-06-13 | アッヴィ・インコーポレイテッド | カルビドパ及びｌ−ドパプロドラッグ並びに使用方法 |
| CN116808243B (zh) * | 2023-08-15 | 2024-04-02 | 上海交通大学 | 苯基-β-D-葡糖苷酸在制备用于诱导式呼气检测肿瘤的药物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9107196D0 (en) * | 1991-04-05 | 1991-05-22 | Sandoz Ag | Improvements in or relating to organic compounds |
| DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| EP0647450A1 (en) * | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| ATE194920T1 (de) * | 1993-09-22 | 2000-08-15 | Hoechst Ag | Pro-prodrugs, ihre herstellung und anwendung |
| US5760072A (en) * | 1995-12-29 | 1998-06-02 | Pharmachemie B.V. | Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy |
| ATE316799T1 (de) * | 1996-03-12 | 2006-02-15 | Sanofi Aventis Deutschland | Neuartige prodrugs für die therapie von tumoren und entzündlichen erkrankungen |
| US6218519B1 (en) * | 1996-04-12 | 2001-04-17 | Pro-Neuron, Inc. | Compounds and methods for the selective treatment of cancer and bacterial infections |
| US5843937A (en) * | 1996-05-23 | 1998-12-01 | Panorama Research, Inc. | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
| US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
| AUPQ342599A0 (en) * | 1999-10-14 | 1999-11-04 | University Of Melbourne, The | Conjugates and uses thereof |
-
2003
- 2003-06-20 NZ NZ537686A patent/NZ537686A/en unknown
- 2003-06-20 CN CNA038178141A patent/CN1671724A/zh active Pending
- 2003-06-20 BR BR0312442-8A patent/BR0312442A/pt not_active IP Right Cessation
- 2003-06-20 JP JP2004515536A patent/JPWO2004000863A1/ja not_active Withdrawn
- 2003-06-20 AU AU2003244088A patent/AU2003244088A1/en not_active Abandoned
- 2003-06-20 EP EP03760921A patent/EP1541579A1/en not_active Withdrawn
- 2003-06-20 WO PCT/JP2003/007868 patent/WO2004000863A1/ja not_active Application Discontinuation
- 2003-06-20 KR KR1020047020745A patent/KR20050027095A/ko not_active Application Discontinuation
- 2003-06-20 US US10/505,961 patent/US20050203061A1/en not_active Abandoned
- 2003-06-20 MX MXPA05000028A patent/MXPA05000028A/es not_active Application Discontinuation
- 2003-06-20 CA CA002490626A patent/CA2490626A1/en not_active Abandoned
-
2005
- 2005-01-19 ZA ZA200500526A patent/ZA200500526B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1541579A1 (en) | 2005-06-15 |
| MXPA05000028A (es) | 2005-08-26 |
| NZ537686A (en) | 2007-01-26 |
| CN1671724A (zh) | 2005-09-21 |
| US20050203061A1 (en) | 2005-09-15 |
| WO2004000863A1 (ja) | 2003-12-31 |
| CA2490626A1 (en) | 2003-12-31 |
| ZA200500526B (en) | 2006-08-30 |
| AU2003244088A1 (en) | 2004-01-06 |
| KR20050027095A (ko) | 2005-03-17 |
| JPWO2004000863A1 (ja) | 2005-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |