BR0311594A - human cell assay to determine the effect of sample compounds on col2 enhancer expression - Google Patents
human cell assay to determine the effect of sample compounds on col2 enhancer expressionInfo
- Publication number
- BR0311594A BR0311594A BRPI0311594-1A BR0311594A BR0311594A BR 0311594 A BR0311594 A BR 0311594A BR 0311594 A BR0311594 A BR 0311594A BR 0311594 A BR0311594 A BR 0311594A
- Authority
- BR
- Brazil
- Prior art keywords
- col2
- effect
- sample compounds
- activity
- human cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"ENSAIO DE CéLULAS HUMANAS PARA DETERMINAR O EFEITO DE COMPOSTOS DE AMOSTRA NA EXPRESSãO DE INTENSIFICADOR DE COL2". A presente invenção refere-se à atividade (crescimento/diferenciação/produção de matriz extracelular) de condrócitos humanos e ao efeito do fator de transcrição Sox9 e do intensificador de Col2 como medida de tal atividade. Refere-se também a uma célula quimérica e a um ensaio utilizando tal célula útil na previsão do efeito de compostos de amostra na atividade de condrócitos medida através da expressão/atividade de Sox9 e Col2."HUMAN CELL TEST TO DETERMINE EFFECT OF SAMPLE COMPOUNDS ON COL2 INTENSIFIER EXPRESSION". The present invention relates to the activity (growth / differentiation / extracellular matrix production) of human chondrocytes and the effect of the transcription factor Sox9 and Col2 enhancer as a measure of such activity. It also refers to a chimeric cell and an assay using such a cell useful in predicting the effect of sample compounds on chondrocyte activity measured by the expression / activity of Sox9 and Col2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38615602P | 2002-06-04 | 2002-06-04 | |
PCT/IB2003/002256 WO2003102130A2 (en) | 2002-06-04 | 2003-05-26 | A human cell assay to determine effect of sample compounds on col2 enhancer expression |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311594A true BR0311594A (en) | 2007-04-27 |
Family
ID=29712234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0311594-1A BR0311594A (en) | 2002-06-04 | 2003-05-26 | human cell assay to determine the effect of sample compounds on col2 enhancer expression |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1576098A2 (en) |
JP (1) | JP2006500915A (en) |
AU (1) | AU2003233009A1 (en) |
BR (1) | BR0311594A (en) |
CA (1) | CA2488006A1 (en) |
MX (1) | MXPA04012042A (en) |
WO (1) | WO2003102130A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010507595A (en) * | 2006-10-27 | 2010-03-11 | ザ・ユニヴァーシティ・オヴ・ウェスタン・オンタリオ | Inhibition of SOX9 function in the treatment of pathophysiological conditions associated with proteoglycans |
KR102084227B1 (en) * | 2018-09-05 | 2020-03-03 | (주)루젠에스씨아이 | Human transformed chondrocyte cell line mediated drug screening system for cartilage disease remedy |
-
2003
- 2003-05-26 BR BRPI0311594-1A patent/BR0311594A/en unknown
- 2003-05-26 CA CA002488006A patent/CA2488006A1/en not_active Abandoned
- 2003-05-26 WO PCT/IB2003/002256 patent/WO2003102130A2/en not_active Application Discontinuation
- 2003-05-26 JP JP2004510372A patent/JP2006500915A/en active Pending
- 2003-05-26 MX MXPA04012042A patent/MXPA04012042A/en unknown
- 2003-05-26 EP EP03727809A patent/EP1576098A2/en not_active Withdrawn
- 2003-05-26 AU AU2003233009A patent/AU2003233009A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1576098A2 (en) | 2005-09-21 |
WO2003102130A3 (en) | 2006-06-22 |
WO2003102130A2 (en) | 2003-12-11 |
JP2006500915A (en) | 2006-01-12 |
AU2003233009A1 (en) | 2003-12-19 |
AU2003233009A8 (en) | 2003-12-19 |
CA2488006A1 (en) | 2003-12-11 |
MXPA04012042A (en) | 2005-03-07 |
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