BR0306784A - Sequência de ácido nucléico isolada, constructo repórter, célula hospedeira compreendendo o mesmo, método de identificação de agentes que modulam a expressão de ingap, método para a modulação da expressão ingap, bem como uso de um fator que estimula uma expressão de ingap na fabricação de uma composição farmacêutica - Google Patents
Sequência de ácido nucléico isolada, constructo repórter, célula hospedeira compreendendo o mesmo, método de identificação de agentes que modulam a expressão de ingap, método para a modulação da expressão ingap, bem como uso de um fator que estimula uma expressão de ingap na fabricação de uma composição farmacêuticaInfo
- Publication number
- BR0306784A BR0306784A BR0306784-0A BR0306784A BR0306784A BR 0306784 A BR0306784 A BR 0306784A BR 0306784 A BR0306784 A BR 0306784A BR 0306784 A BR0306784 A BR 0306784A
- Authority
- BR
- Brazil
- Prior art keywords
- expression
- ingap expression
- ingap
- reporter construct
- nucleic acid
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4733—Acute pancreatitis-associated protein
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/474—Pancreatic thread protein; Reg protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4733—Acute pancreatitis-associated protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/474—Pancreatic thread protein; Reg protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"SEQuêNCIA DE áCIDO NUCLéICO ISOLADA, CONSTRUCTO REPóRTER, CéLULA HOSPEDEIRA COMPREENDENDO O MESMO, MéTODO DE IDENTIFICAçãO DE AGENTES QUE MODULAM A EXPRESSãO DE INGAP, MéTODO PARA A MODULAçãO DA EXPRESSãO INGAP, BEM COMO USO DE UM FATOR QUE ESTIMULA UMA EXPRESSãO DE INGAP NA FABRICAçãO DE UMA COMPOSIçãO FARMACêUTICA". A presente invenção refere-se a um constructo repórter que contém a região reguladora 5<39> de INGAP de mamífero ou um fragmento da mesma, um elemento promotor mínimo de INGAP de mamífero ou um promotor heterólogo, e um gene repórter. O constructo repórter pode ser utilizado para a triagem de agentes que, isoladamente ou em combinação, regulam para cima ou regulam para baixo a expressão do gene repórter. Alternativamente, o constructo repórter pode ser utilizado para a triagem de agentes que se ligam à região reguladora 5<39> de INGAP do hamster, ou um fragmento da mesma.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34689802P | 2002-01-11 | 2002-01-11 | |
US36107302P | 2002-03-01 | 2002-03-01 | |
US38831502P | 2002-06-14 | 2002-06-14 | |
PCT/US2003/000707 WO2003060096A2 (en) | 2002-01-11 | 2003-01-10 | Assay for the detection of factors that modulate the expression of ingap |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0306784A true BR0306784A (pt) | 2005-04-26 |
Family
ID=27407757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0306784-0A BR0306784A (pt) | 2002-01-11 | 2003-01-10 | Sequência de ácido nucléico isolada, constructo repórter, célula hospedeira compreendendo o mesmo, método de identificação de agentes que modulam a expressão de ingap, método para a modulação da expressão ingap, bem como uso de um fator que estimula uma expressão de ingap na fabricação de uma composição farmacêutica |
Country Status (13)
Country | Link |
---|---|
US (3) | US7355024B2 (pt) |
EP (1) | EP1463517A4 (pt) |
JP (1) | JP2005514930A (pt) |
KR (2) | KR20070043057A (pt) |
CN (1) | CN1615150A (pt) |
BR (1) | BR0306784A (pt) |
CA (1) | CA2470359A1 (pt) |
IL (1) | IL162493A0 (pt) |
MA (1) | MA27241A1 (pt) |
MX (1) | MXPA04006708A (pt) |
NO (1) | NO20043330L (pt) |
PL (1) | PL371485A1 (pt) |
WO (1) | WO2003060096A2 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103305457B (zh) * | 2013-06-06 | 2015-07-08 | 浙江省医学科学院 | 一种体外扩增胰岛β细胞的方法 |
WO2017186121A1 (zh) * | 2016-04-26 | 2017-11-02 | 科济生物医药(上海)有限公司 | 一种改善免疫应答细胞功能的方法 |
CN110906869A (zh) * | 2019-11-22 | 2020-03-24 | 深圳市太赫兹科技创新研究院有限公司 | 一种oct探头调节装置 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE494374T1 (de) | 1995-02-22 | 2011-01-15 | Eastern Virginia Med School | Ingap-protein und dessen beteiligung an der neogenese pankreatischer inselzellen |
US5834590A (en) | 1995-02-22 | 1998-11-10 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Ingap protein involved in pancreatic islet neogenesis |
US6090620A (en) * | 1995-12-29 | 2000-07-18 | University Of Washington | Genes and gene products related to Werner's syndrome |
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2003
- 2003-01-09 US US10/339,767 patent/US7355024B2/en not_active Expired - Fee Related
- 2003-01-10 EP EP03701289A patent/EP1463517A4/en not_active Withdrawn
- 2003-01-10 MX MXPA04006708A patent/MXPA04006708A/es not_active Application Discontinuation
- 2003-01-10 CN CNA038021455A patent/CN1615150A/zh active Pending
- 2003-01-10 JP JP2003560183A patent/JP2005514930A/ja active Pending
- 2003-01-10 KR KR1020077007413A patent/KR20070043057A/ko not_active Application Discontinuation
- 2003-01-10 KR KR1020047010535A patent/KR100766759B1/ko not_active IP Right Cessation
- 2003-01-10 BR BR0306784-0A patent/BR0306784A/pt not_active IP Right Cessation
- 2003-01-10 CA CA002470359A patent/CA2470359A1/en not_active Abandoned
- 2003-01-10 IL IL16249303A patent/IL162493A0/xx unknown
- 2003-01-10 PL PL03371485A patent/PL371485A1/xx not_active Application Discontinuation
- 2003-01-10 WO PCT/US2003/000707 patent/WO2003060096A2/en active IP Right Grant
-
2004
- 2004-07-07 MA MA27770A patent/MA27241A1/fr unknown
- 2004-08-10 NO NO20043330A patent/NO20043330L/no not_active Application Discontinuation
-
2008
- 2008-04-04 US US12/062,740 patent/US20090156458A1/en not_active Abandoned
-
2011
- 2011-08-01 US US13/195,596 patent/US20120058078A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PL371485A1 (en) | 2005-06-13 |
JP2005514930A (ja) | 2005-05-26 |
KR20070043057A (ko) | 2007-04-24 |
AU2003202273A1 (en) | 2003-07-30 |
US7355024B2 (en) | 2008-04-08 |
US20030207301A1 (en) | 2003-11-06 |
WO2003060096A3 (en) | 2003-12-04 |
NO20043330L (no) | 2004-10-05 |
CN1615150A (zh) | 2005-05-11 |
IL162493A0 (en) | 2005-11-20 |
EP1463517A4 (en) | 2006-01-04 |
KR100766759B1 (ko) | 2007-10-15 |
KR20040072700A (ko) | 2004-08-18 |
US20120058078A1 (en) | 2012-03-08 |
WO2003060096A2 (en) | 2003-07-24 |
MXPA04006708A (es) | 2005-03-31 |
US20090156458A1 (en) | 2009-06-18 |
MA27241A1 (fr) | 2005-03-01 |
CA2470359A1 (en) | 2003-07-24 |
EP1463517A2 (en) | 2004-10-06 |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2047 DE 30/03/2010. |