BR0306656A - Transdiferenciação das células pancreáticas acinares - Google Patents
Transdiferenciação das células pancreáticas acinaresInfo
- Publication number
- BR0306656A BR0306656A BR0306656-8A BR0306656A BR0306656A BR 0306656 A BR0306656 A BR 0306656A BR 0306656 A BR0306656 A BR 0306656A BR 0306656 A BR0306656 A BR 0306656A
- Authority
- BR
- Brazil
- Prior art keywords
- cell
- cells
- acinar
- pdo
- weeks
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
"TRANSDIFERENCIAçãO DAS CéLULAS PANCREáTICAS ACINARES". A indução da neogênese de células-<225> foi associada com epitélio ductal, entretanto <sym>80% do pâncreas é composto de células acinares. Surpreendentemente, as células pancreáticas acinares contribuem para a neogênese da célula-<225>. A obstrução do ducto parcial (PDO) do pâncreas é um indutor conhecido da neogênese da célula-<225> levando a expansão da massa de células-<225> e o efeito parece ser mediado pela INGAP, uma proteína da célula acinar originalmente identificada no pâncreas regenerado de hamster. Examinamos os efeitos da PDO na incorporação da timidina tritiada pelas células acinares e células-<225> do pâncreas em hamster Sírios fêmeas. Uma única dose de timidina tritiada foi administrada para todos os animais duas semanas após PDO. Os animais foram então sacrificadas com 1 hora, ou com seis semanas após-injeção. A incorporação da timidina em células acinares foi maior com 2 semanas após PDO e foi reduzida com 8 semanas após PDO. A incorporação da timidina tritiada nas células-<225> estava inversamente relacionada ao que foi observado nas células acinares. Duas semanas após PDO, a captação da timidina tritiada das células-<225> foi relativamente lenta e aumentou significativamente com 8 semanas após PDO, de acordo com a neogênese da célula-<225> originada de célula acinar. A microscopia eletrónica demonstrou células com grânulos de zimogênio e grânulos endócrinos, sugerindo também transdiferenciação de célula acinar em endócrina. Em um segundo experimento, os hamsters receberam um pentadecapeptídeo de proteína de INGAP ou um volume equivalente de solução salina por 10 dias. Ocorreu um aumento duplo no número de cadeias de células-<225> acinar-associadas extra-ilhota nos hamsters tratados com peptídeo INGAP resultando em um aumento de 2,8 vezes na massa de células-<225>. A diferenciação de células acinares em células-<225> proporciona uma via alternativa para neogênese das células-<225>; o peptídeo INGAP exerce um papel significativo neste processo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34689002P | 2002-01-11 | 2002-01-11 | |
| PCT/CA2003/000013 WO2003057862A2 (en) | 2002-01-11 | 2003-01-10 | Transdifferentiation of pancreatic acinar cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0306656A true BR0306656A (pt) | 2004-10-05 |
Family
ID=23361448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0306656-8A BR0306656A (pt) | 2002-01-11 | 2003-01-10 | Transdiferenciação das células pancreáticas acinares |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7662768B2 (pt) |
| EP (1) | EP1463801B1 (pt) |
| JP (1) | JP2005514426A (pt) |
| KR (1) | KR20040072680A (pt) |
| CN (1) | CN1610693A (pt) |
| AR (1) | AR038281A1 (pt) |
| AT (1) | ATE404661T1 (pt) |
| AU (1) | AU2003201553A1 (pt) |
| BR (1) | BR0306656A (pt) |
| CA (1) | CA2469052A1 (pt) |
| DE (1) | DE60322831D1 (pt) |
| IL (1) | IL162749A0 (pt) |
| MA (1) | MA27413A1 (pt) |
| MX (1) | MXPA04006385A (pt) |
| NO (1) | NO20042205L (pt) |
| PE (1) | PE20030744A1 (pt) |
| PL (1) | PL371260A1 (pt) |
| RU (1) | RU2004119417A (pt) |
| TW (1) | TW200302228A (pt) |
| WO (1) | WO2003057862A2 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004037277A2 (en) * | 2002-10-24 | 2004-05-06 | Mcgill University | Use of ingap for reversing diabetes |
| WO2014139182A1 (en) | 2013-03-15 | 2014-09-18 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69638315D1 (de) | 1995-02-22 | 2011-02-17 | Eastern Virginia Med School | Ingap-protein und dessen beteiligung an der neogenese pankreatischer inselzellen |
| US5834590A (en) | 1995-02-22 | 1998-11-10 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Ingap protein involved in pancreatic islet neogenesis |
| US20030138951A1 (en) * | 2001-10-18 | 2003-07-24 | Li Yin | Conversion of liver stem and progenitor cells to pancreatic functional cells |
-
2003
- 2003-01-08 US US10/338,028 patent/US7662768B2/en not_active Expired - Fee Related
- 2003-01-09 AR ARP030100050A patent/AR038281A1/es unknown
- 2003-01-09 PE PE2003000035A patent/PE20030744A1/es not_active Application Discontinuation
- 2003-01-10 AT AT03700250T patent/ATE404661T1/de not_active IP Right Cessation
- 2003-01-10 BR BR0306656-8A patent/BR0306656A/pt not_active Application Discontinuation
- 2003-01-10 IL IL16274903A patent/IL162749A0/xx unknown
- 2003-01-10 WO PCT/CA2003/000013 patent/WO2003057862A2/en active IP Right Grant
- 2003-01-10 CN CNA038018616A patent/CN1610693A/zh active Pending
- 2003-01-10 TW TW092100552A patent/TW200302228A/zh unknown
- 2003-01-10 KR KR10-2004-7010139A patent/KR20040072680A/ko not_active Application Discontinuation
- 2003-01-10 AU AU2003201553A patent/AU2003201553A1/en not_active Abandoned
- 2003-01-10 JP JP2003558163A patent/JP2005514426A/ja active Pending
- 2003-01-10 RU RU2004119417/14A patent/RU2004119417A/ru not_active Application Discontinuation
- 2003-01-10 MX MXPA04006385A patent/MXPA04006385A/es not_active Application Discontinuation
- 2003-01-10 PL PL03371260A patent/PL371260A1/xx unknown
- 2003-01-10 CA CA002469052A patent/CA2469052A1/en not_active Abandoned
- 2003-01-10 EP EP03700250A patent/EP1463801B1/en not_active Expired - Lifetime
- 2003-01-10 DE DE60322831T patent/DE60322831D1/de not_active Expired - Lifetime
-
2004
- 2004-05-28 NO NO20042205A patent/NO20042205L/no not_active Application Discontinuation
- 2004-06-28 MA MA27750A patent/MA27413A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1610693A (zh) | 2005-04-27 |
| KR20040072680A (ko) | 2004-08-18 |
| WO2003057862A3 (en) | 2003-10-02 |
| DE60322831D1 (de) | 2008-09-25 |
| PL371260A1 (en) | 2005-06-13 |
| EP1463801A2 (en) | 2004-10-06 |
| IL162749A0 (en) | 2005-11-20 |
| TW200302228A (en) | 2003-08-01 |
| EP1463801B1 (en) | 2008-08-13 |
| MXPA04006385A (es) | 2004-10-04 |
| WO2003057862A2 (en) | 2003-07-17 |
| CA2469052A1 (en) | 2003-07-17 |
| US7662768B2 (en) | 2010-02-16 |
| AU2003201553A1 (en) | 2003-07-24 |
| RU2004119417A (ru) | 2005-02-27 |
| PE20030744A1 (es) | 2003-10-24 |
| AR038281A1 (es) | 2005-01-12 |
| MA27413A1 (fr) | 2005-07-01 |
| US20030203850A1 (en) | 2003-10-30 |
| ATE404661T1 (de) | 2008-08-15 |
| NO20042205L (no) | 2004-09-13 |
| JP2005514426A (ja) | 2005-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |