BR0304827A - Proteìna quimérica recombinante, e, cadeia de ácido nucléico - Google Patents
Proteìna quimérica recombinante, e, cadeia de ácido nucléicoInfo
- Publication number
- BR0304827A BR0304827A BR0304827-6A BR0304827A BR0304827A BR 0304827 A BR0304827 A BR 0304827A BR 0304827 A BR0304827 A BR 0304827A BR 0304827 A BR0304827 A BR 0304827A
- Authority
- BR
- Brazil
- Prior art keywords
- ifn
- nucleic acid
- inhibits
- chimeric protein
- acid chain
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical group 0.000 title abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000006354 HLA-DR Antigens Human genes 0.000 abstract 1
- 108010058597 HLA-DR Antigens Proteins 0.000 abstract 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 230000006020 chronic inflammation Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 102000055277 human IL2 Human genes 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 210000004897 n-terminal region Anatomy 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7156—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
"PROTEìNA QUIMéRICA RECOMBINANTE, E, CADEIA DE áCIDO NUCLéICO". Proteína quimérica recombinante composta por um fragmento de 60 aminoácidos da região N-terminal da interleucina 2 (IL-2) humana fusionado à ponta N da região extracelular da cadeia alfa do receptor para IFN gama (IFN g). Esta proteina in vitro apresenta atividade estimuladora do crescimento de células T, inibe a atividade estimuladora do crescimento de IL-2 em células T, inibe a indução de HLA-DR pelo IFN g e inibe a atividade antiproliferativa do IFN g. Esta invenção pode ser aplicada no campo da medicina para o tratamento de várias patologias, como doenças auto-imunes, rejeição a transplantes, inflamações crónicas, sépse, síndrome de isquemia e reperfusão e aterosclerose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20020095A CU23229A1 (es) | 2002-05-10 | 2002-05-10 | ANTAGONISTA QUIMéRICO ANTH1 |
PCT/CU2003/000006 WO2003095488A1 (es) | 2002-05-10 | 2003-05-08 | Antagonista quimérico anth1 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0304827A true BR0304827A (pt) | 2004-08-17 |
Family
ID=40091620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0304827-6A BR0304827A (pt) | 2002-05-10 | 2003-05-08 | Proteìna quimérica recombinante, e, cadeia de ácido nucléico |
Country Status (17)
Country | Link |
---|---|
US (2) | US7429384B2 (pt) |
EP (1) | EP1550672B1 (pt) |
JP (1) | JP4275065B2 (pt) |
KR (1) | KR20040108786A (pt) |
CN (1) | CN100384873C (pt) |
AR (1) | AR039973A1 (pt) |
AT (1) | ATE439379T1 (pt) |
AU (1) | AU2003223832B2 (pt) |
BR (1) | BR0304827A (pt) |
CA (1) | CA2485439A1 (pt) |
CU (1) | CU23229A1 (pt) |
DE (1) | DE60328807D1 (pt) |
MX (1) | MXPA04011143A (pt) |
RU (1) | RU2322455C2 (pt) |
UA (1) | UA81908C2 (pt) |
WO (1) | WO2003095488A1 (pt) |
ZA (1) | ZA200409073B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA023069B1 (ru) * | 2008-04-09 | 2016-04-29 | Корнелл Юниверсити | Изолированные рекомбинантные кишечные симбиотические бактерии и их применение |
BR112013008957A2 (pt) | 2010-10-15 | 2019-09-24 | Univ Cornell | composições e métodos para tratamento de doenças endócrinas, gastrointestinais ou autoimunes |
EP2994146B8 (en) * | 2013-05-08 | 2021-05-19 | Clene Nanomedicine, Inc. | Methods and treatment for certain demyelination and dysmyelination-based disorders and/or promoting remyelination |
CN107266586A (zh) * | 2017-08-09 | 2017-10-20 | 安徽九川生物科技有限公司 | 一种重组猪长效干扰素γ及制备此长效干扰素γ的融合蛋白及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE132191T1 (de) * | 1989-04-19 | 1996-01-15 | Hoffmann La Roche | Auflösbare interferon-gamma-rezeptoren sowie verfahren zu deren herstellung |
US5073627A (en) * | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
CA2114168A1 (en) * | 1993-03-05 | 1994-09-06 | Zlatko Dembic | Chimeric human interferon-gamma-receptor/immunoglobulin polypeptides |
WO1994021282A1 (en) | 1993-03-19 | 1994-09-29 | Immunex Corporation | Pharmaceutical compositions comprising a ligand complexed with a soluble receptor |
US5582826A (en) * | 1993-04-21 | 1996-12-10 | Ajinomoto Co., Inc. | Monoclonal antibodies which bind the gamma chain of human interleukin-2 receptor |
-
2002
- 2002-05-10 CU CU20020095A patent/CU23229A1/es unknown
-
2003
- 2003-05-07 AR ARP030101604A patent/AR039973A1/es active IP Right Grant
- 2003-05-08 BR BR0304827-6A patent/BR0304827A/pt not_active IP Right Cessation
- 2003-05-08 JP JP2004503502A patent/JP4275065B2/ja not_active Expired - Fee Related
- 2003-05-08 DE DE60328807T patent/DE60328807D1/de not_active Expired - Fee Related
- 2003-05-08 AU AU2003223832A patent/AU2003223832B2/en not_active Ceased
- 2003-05-08 AT AT03720120T patent/ATE439379T1/de not_active IP Right Cessation
- 2003-05-08 CN CNB038141264A patent/CN100384873C/zh not_active Expired - Fee Related
- 2003-05-08 KR KR10-2004-7017991A patent/KR20040108786A/ko not_active Application Discontinuation
- 2003-05-08 WO PCT/CU2003/000006 patent/WO2003095488A1/es active Application Filing
- 2003-05-08 RU RU2004136170/13A patent/RU2322455C2/ru active
- 2003-05-08 US US10/513,931 patent/US7429384B2/en not_active Expired - Fee Related
- 2003-05-08 MX MXPA04011143A patent/MXPA04011143A/es active IP Right Grant
- 2003-05-08 EP EP03720120A patent/EP1550672B1/en not_active Expired - Lifetime
- 2003-05-08 CA CA002485439A patent/CA2485439A1/en not_active Abandoned
- 2003-08-05 UA UA20041210147A patent/UA81908C2/uk unknown
-
2004
- 2004-11-09 ZA ZA200409073A patent/ZA200409073B/en unknown
-
2007
- 2007-01-22 US US11/656,301 patent/US20070160575A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE439379T1 (de) | 2009-08-15 |
AR039973A1 (es) | 2005-03-09 |
EP1550672A1 (en) | 2005-07-06 |
CU23229A1 (es) | 2007-09-26 |
CA2485439A1 (en) | 2003-11-20 |
US20070160575A1 (en) | 2007-07-12 |
UA81908C2 (uk) | 2008-02-25 |
CN100384873C (zh) | 2008-04-30 |
KR20040108786A (ko) | 2004-12-24 |
RU2004136170A (ru) | 2005-05-27 |
WO2003095488A1 (es) | 2003-11-20 |
JP2006506958A (ja) | 2006-03-02 |
US7429384B2 (en) | 2008-09-30 |
ZA200409073B (en) | 2005-05-09 |
RU2322455C2 (ru) | 2008-04-20 |
CN1662555A (zh) | 2005-08-31 |
DE60328807D1 (de) | 2009-09-24 |
AU2003223832A1 (en) | 2003-11-11 |
MXPA04011143A (es) | 2005-01-25 |
EP1550672B1 (en) | 2009-08-12 |
US20060073115A1 (en) | 2006-04-06 |
JP4275065B2 (ja) | 2009-06-10 |
AU2003223832B2 (en) | 2009-02-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A(S) 8A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011. |