BR0214567A - Epìtopos de célula t em carboxipeptidase g2 - Google Patents
Epìtopos de célula t em carboxipeptidase g2Info
- Publication number
- BR0214567A BR0214567A BR0214567-7A BR0214567A BR0214567A BR 0214567 A BR0214567 A BR 0214567A BR 0214567 A BR0214567 A BR 0214567A BR 0214567 A BR0214567 A BR 0214567A
- Authority
- BR
- Brazil
- Prior art keywords
- carboxypeptidase
- cpg2
- cell epitopes
- relates
- modified
- Prior art date
Links
- 108010062699 gamma-Glutamyl Hydrolase Proteins 0.000 title abstract 5
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 241001515965 unidentified phage Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"EPìTOPOS DE CéLULA T EM CARBOXIPEPTIDASE G2". A invenção refere-se em particular à modificação da enzima bactedana carboxipeptidase G2 (CPG2) para resultar em proteínas CPG2 que são substancialmente não-imunogênicas ou menos imunogênicas do que qualquer par não-modificado quando usadas in vivo. A presente invenção referese também a peptídeos de epítopo de célula T derivados da dita proteína não-modificada através da qual é possível criar variantes de CPG2 modificadas com imunogenicidade reduzida. Esses polipeptídeos são adequados particularmente para uso terapêutico em seres humanos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01128519 | 2001-11-29 | ||
| EP02001778 | 2002-01-25 | ||
| EP02020634 | 2002-09-13 | ||
| PCT/EP2002/013351 WO2003045426A1 (en) | 2001-11-29 | 2002-11-27 | T-cell epitodes in carboxypeptidase g2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0214567A true BR0214567A (pt) | 2004-12-28 |
Family
ID=27224249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0214567-7A BR0214567A (pt) | 2001-11-29 | 2002-11-27 | Epìtopos de célula t em carboxipeptidase g2 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050074863A1 (pt) |
| EP (1) | EP1501540A1 (pt) |
| JP (1) | JP2005510227A (pt) |
| KR (1) | KR20040068561A (pt) |
| CN (1) | CN1592633A (pt) |
| AU (1) | AU2002352162A1 (pt) |
| BR (1) | BR0214567A (pt) |
| CA (1) | CA2468501A1 (pt) |
| HU (1) | HUP0402160A3 (pt) |
| MX (1) | MXPA04004970A (pt) |
| PL (1) | PL369735A1 (pt) |
| WO (1) | WO2003045426A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252897B2 (en) * | 2007-06-21 | 2012-08-28 | Angelica Therapeutics, Inc. | Modified toxins |
| EP2268297A4 (en) * | 2008-02-29 | 2011-11-16 | Angelica Therapeutics Inc | MODIFIED TOXINS |
| CA2902905A1 (en) | 2013-03-15 | 2014-09-25 | Claude Geoffrey Davis | Modified toxins |
| GB201308363D0 (en) | 2013-05-09 | 2013-06-19 | Bagshawe Kenneth D | Tumour therapy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656718B2 (en) * | 2000-07-07 | 2003-12-02 | Cancer Research Technology Limited | Modified carboxypeptidase enzymes and their use |
| ES2309167T3 (es) * | 2001-02-19 | 2008-12-16 | Merck Patent Gmbh | Metodo para identificar epitotes de celulas t y metodo para preparar moleculas con inmunogenicidad reducida. |
-
2002
- 2002-11-27 AU AU2002352162A patent/AU2002352162A1/en not_active Abandoned
- 2002-11-27 WO PCT/EP2002/013351 patent/WO2003045426A1/en active Application Filing
- 2002-11-27 HU HU0402160A patent/HUP0402160A3/hu unknown
- 2002-11-27 PL PL02369735A patent/PL369735A1/xx not_active Application Discontinuation
- 2002-11-27 EP EP02787840A patent/EP1501540A1/en not_active Withdrawn
- 2002-11-27 CA CA002468501A patent/CA2468501A1/en not_active Abandoned
- 2002-11-27 CN CNA028233018A patent/CN1592633A/zh active Pending
- 2002-11-27 BR BR0214567-7A patent/BR0214567A/pt not_active Application Discontinuation
- 2002-11-27 KR KR10-2004-7008183A patent/KR20040068561A/ko not_active Application Discontinuation
- 2002-11-27 US US10/497,091 patent/US20050074863A1/en not_active Abandoned
- 2002-11-27 MX MXPA04004970A patent/MXPA04004970A/es not_active Application Discontinuation
- 2002-11-27 JP JP2003546927A patent/JP2005510227A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1592633A (zh) | 2005-03-09 |
| JP2005510227A (ja) | 2005-04-21 |
| KR20040068561A (ko) | 2004-07-31 |
| US20050074863A1 (en) | 2005-04-07 |
| EP1501540A1 (en) | 2005-02-02 |
| CA2468501A1 (en) | 2003-06-05 |
| PL369735A1 (en) | 2005-05-02 |
| AU2002352162A1 (en) | 2003-06-10 |
| WO2003045426A1 (en) | 2003-06-05 |
| HUP0402160A3 (en) | 2007-05-02 |
| HUP0402160A2 (hu) | 2005-01-28 |
| MXPA04004970A (es) | 2004-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |