BR0209194A - Processo para a produção de citalopram - Google Patents

Processo para a produção de citalopram

Info

Publication number
BR0209194A
BR0209194A BR0209194-1A BR0209194A BR0209194A BR 0209194 A BR0209194 A BR 0209194A BR 0209194 A BR0209194 A BR 0209194A BR 0209194 A BR0209194 A BR 0209194A
Authority
BR
Brazil
Prior art keywords
citalopram
production
salts
careful
chlorocitalopram
Prior art date
Application number
BR0209194-1A
Other languages
English (en)
Inventor
Venkata Ramana Rao Chunchu
Satyanarayana Chava
Hari Babu Bodepudi
Jyothi Basu Abbineni
Original Assignee
Matrix Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Lab Ltd filed Critical Matrix Lab Ltd
Publication of BR0209194A publication Critical patent/BR0209194A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A PRODUçãO DE CITALOPRAM". A invenção refere-se a um processo para a fabricação de sais de citalopram de alta pureza. Pela cuidadosa seleção de solventes e cuidados a manipulação do valor do pH, os sais de citalopram podem ser isolados na ausência de 5-clorocitalopram, 5-bromocitalopram, desmetil-citalopram e 5-carboxiamida citalopram.
BR0209194-1A 2002-02-27 2002-04-18 Processo para a produção de citalopram BR0209194A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0204607.6A GB0204607D0 (en) 2002-02-27 2002-02-27 Process
PCT/IB2002/003832 WO2003072565A1 (en) 2002-02-27 2002-04-18 Process for the production of citalopram

Publications (1)

Publication Number Publication Date
BR0209194A true BR0209194A (pt) 2004-06-08

Family

ID=9931900

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209194-1A BR0209194A (pt) 2002-02-27 2002-04-18 Processo para a produção de citalopram

Country Status (15)

Country Link
US (1) US7365216B2 (pt)
EP (1) EP1478635A1 (pt)
JP (1) JP4331618B2 (pt)
CN (1) CN1267427C (pt)
AU (1) AU2002367728A1 (pt)
BR (1) BR0209194A (pt)
CA (1) CA2444940A1 (pt)
CZ (1) CZ200465A3 (pt)
GB (2) GB0204607D0 (pt)
IL (1) IL158400A0 (pt)
MX (1) MXPA03009695A (pt)
NZ (1) NZ529070A (pt)
SK (1) SK882004A3 (pt)
WO (1) WO2003072565A1 (pt)
ZA (1) ZA200308115B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
GB0317475D0 (en) 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
TW200507850A (en) * 2003-07-25 2005-03-01 Kyowa Hakko Kogyo Kk Pharmaceutical composition
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
DK2595979T3 (en) 2010-07-23 2016-05-17 Lundbeck & Co As H A process for the purification of pharmaceutically acceptable salts of escitalopram
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CA2360303C (en) * 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
ES2194597B2 (es) 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process

Also Published As

Publication number Publication date
CN1509279A (zh) 2004-06-30
SK882004A3 (en) 2004-06-08
US7365216B2 (en) 2008-04-29
GB0210225D0 (en) 2002-06-12
AU2002367728A1 (en) 2003-09-09
GB2375763A (en) 2002-11-27
GB2375763B (en) 2003-09-24
IL158400A0 (en) 2004-05-12
ZA200308115B (en) 2004-07-05
WO2003072565A1 (en) 2003-09-04
EP1478635A1 (en) 2004-11-24
CZ200465A3 (cs) 2004-04-14
JP4331618B2 (ja) 2009-09-16
CN1267427C (zh) 2006-08-02
JP2005518445A (ja) 2005-06-23
GB0204607D0 (en) 2002-04-10
MXPA03009695A (es) 2005-03-07
NZ529070A (en) 2006-02-24
US20040259939A1 (en) 2004-12-23
CA2444940A1 (en) 2003-09-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 7A. E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.