BR0206650A - Composto, composição farmacêutica, uso de pelo menos um composto, e, proceso para a preparação de um composto - Google Patents
Composto, composição farmacêutica, uso de pelo menos um composto, e, proceso para a preparação de um compostoInfo
- Publication number
- BR0206650A BR0206650A BR0206650-5A BR0206650A BR0206650A BR 0206650 A BR0206650 A BR 0206650A BR 0206650 A BR0206650 A BR 0206650A BR 0206650 A BR0206650 A BR 0206650A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- optionally substituted
- substituent
- groups
- substituent group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE PELO MENOS UM COMPOSTO, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". Compostos de fórmula (I): [em que: A é um anel pirrol; R^ 1^ é um grupo arila ou heteroarila opcionalmente substituído; R^ 2^ é um grupo heteroarila contendo-nitrogênio opcionalmente substituído; e R^ 3^ é fórmulas (IIa), (IIb) ou (IIc), em que m é 1 ou 2, um de D e E é nitrogênio e o outro >C(R^ 5^)- (em que R^ 5^ é hidrogênio, um Substituinte <244> ou um Substituinte <225>, B é um anel heterocíclico contendo-nitrogênio com de 4 a 7 membros, e R^ 4^ é de 1 a 3 substituintes do Grupo substituinte <244>, Grupo substituinte <225> e Grupo substituinte <sym>; DESDE QUE R^ 1^ e R^ 3^ sejam ligados aos dois átomos do referido anel pirrol que são adjacentes ao átomo do anel pirrol ao qual referido substituinte R^ 2^ está ligado; Grupo substituinte <244> consiste de grupos hidroxila, nItro, ciano, halogênio, alcóxi, halogênio alcóxi, alquiltio e halogênio alquiltio e grupos de fórmula -NR^ a^R^ B^ (em que R^ a^ e R^ b^, são hidrogênio, alquila, alquenila, alquinila, aralquila e alquilsulfonila, ou R^ a^ e R^ b^, em conjunto com o átomo de nitrogênio ao qual estão ligados, formam um heterociclila); Grupo substituinte <225> consiste de grupos alquila, alquenila e alquinila opcionalmente substituídos, e grupos aralquila e cicloalquila; Grupo de substituintes <sym> consiste de grupos oxo, hidroxiimino, alcoxiimino, alquileno, alquilenodióxi, alquilsulfinila, alquilsulfonila, arila opcionalmente substituído, arilóxi opcionalmente substituído, alquilidenila e aralquilidenila] apresentam excelente atividade contra a produção de citocinas inflamatórias.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001013817 | 2001-01-22 | ||
| US27500501P | 2001-03-12 | 2001-03-12 | |
| PCT/IB2002/000176 WO2002057264A1 (en) | 2001-01-22 | 2002-01-22 | Pyrrole derivates for treating cytokine mediated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0206650A true BR0206650A (pt) | 2004-02-25 |
Family
ID=26608097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0206650-5A BR0206650A (pt) | 2001-01-22 | 2002-01-22 | Composto, composição farmacêutica, uso de pelo menos um composto, e, proceso para a preparação de um composto |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1377577B1 (pt) |
| KR (1) | KR20030076619A (pt) |
| CN (1) | CN100371336C (pt) |
| AR (1) | AR032511A1 (pt) |
| AT (1) | ATE329915T1 (pt) |
| BR (1) | BR0206650A (pt) |
| CA (1) | CA2435692A1 (pt) |
| CZ (1) | CZ20031949A3 (pt) |
| DE (1) | DE60212357T2 (pt) |
| EG (1) | EG23054A (pt) |
| ES (1) | ES2266500T3 (pt) |
| HU (1) | HUP0302807A2 (pt) |
| IL (1) | IL156861A0 (pt) |
| MX (1) | MXPA03006515A (pt) |
| NO (1) | NO20033290L (pt) |
| NZ (1) | NZ527099A (pt) |
| PE (1) | PE20030197A1 (pt) |
| PL (1) | PL362896A1 (pt) |
| RU (1) | RU2003122364A (pt) |
| SK (1) | SK9282003A3 (pt) |
| WO (1) | WO2002057264A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003015781A1 (fr) * | 2001-08-15 | 2003-02-27 | Sankyo Company, Limited | Nouvelles compositions pharmaceutiques antidiabetiques |
| EP1541571A4 (en) * | 2002-07-19 | 2008-12-03 | Sankyo Co | BICYCLIC, UNSATURATED TERTIARY AMINE COMPOUND |
| SI1830869T1 (sl) | 2004-12-24 | 2013-12-31 | Spinifex Pharmaceuticals Pty Ltd | Postopek zdravljenja ali profilakse |
| US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
| CA2866540A1 (en) | 2006-03-20 | 2007-09-27 | Spinifex Pharmaceuticals Pty Ltd. | Method of treatment or prophylaxis of inflammatory pain |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792778A (en) * | 1995-08-10 | 1998-08-11 | Merck & Co., Inc. | 2-substituted aryl pyrroles, compositions containing such compounds and methods of use |
| AU699148B2 (en) * | 1995-08-10 | 1998-11-26 | Merck & Co., Inc. | 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use |
| US5837719A (en) * | 1995-08-10 | 1998-11-17 | Merck & Co., Inc. | 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use |
| IL137365A0 (en) * | 1999-07-21 | 2001-07-24 | Sankyo Co | Heteroaryl-substituted pyrrole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
-
2002
- 2002-01-20 EG EG20020068A patent/EG23054A/xx active
- 2002-01-22 PE PE2002000046A patent/PE20030197A1/es not_active Application Discontinuation
- 2002-01-22 PL PL02362896A patent/PL362896A1/xx not_active Application Discontinuation
- 2002-01-22 IL IL15686102A patent/IL156861A0/xx unknown
- 2002-01-22 NZ NZ527099A patent/NZ527099A/en unknown
- 2002-01-22 CZ CZ20031949A patent/CZ20031949A3/cs unknown
- 2002-01-22 AT AT02732180T patent/ATE329915T1/de not_active IP Right Cessation
- 2002-01-22 RU RU2003122364/04A patent/RU2003122364A/ru unknown
- 2002-01-22 EP EP02732180A patent/EP1377577B1/en not_active Expired - Lifetime
- 2002-01-22 BR BR0206650-5A patent/BR0206650A/pt not_active IP Right Cessation
- 2002-01-22 CN CNB028069781A patent/CN100371336C/zh not_active Expired - Fee Related
- 2002-01-22 ES ES02732180T patent/ES2266500T3/es not_active Expired - Lifetime
- 2002-01-22 HU HU0302807A patent/HUP0302807A2/hu unknown
- 2002-01-22 DE DE60212357T patent/DE60212357T2/de not_active Expired - Fee Related
- 2002-01-22 WO PCT/IB2002/000176 patent/WO2002057264A1/en active IP Right Grant
- 2002-01-22 MX MXPA03006515A patent/MXPA03006515A/es unknown
- 2002-01-22 KR KR10-2003-7009619A patent/KR20030076619A/ko not_active Application Discontinuation
- 2002-01-22 SK SK928-2003A patent/SK9282003A3/sk not_active Application Discontinuation
- 2002-01-22 CA CA002435692A patent/CA2435692A1/en not_active Abandoned
- 2002-01-22 AR ARP020100212A patent/AR032511A1/es unknown
-
2003
- 2003-07-21 NO NO20033290A patent/NO20033290L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL156861A0 (en) | 2004-02-08 |
| CA2435692A1 (en) | 2002-07-25 |
| PL362896A1 (en) | 2004-11-02 |
| NZ527099A (en) | 2004-09-24 |
| ES2266500T3 (es) | 2007-03-01 |
| ATE329915T1 (de) | 2006-07-15 |
| WO2002057264A1 (en) | 2002-07-25 |
| NO20033290D0 (no) | 2003-07-21 |
| CZ20031949A3 (cs) | 2003-12-17 |
| EG23054A (en) | 2004-02-29 |
| KR20030076619A (ko) | 2003-09-26 |
| SK9282003A3 (en) | 2004-04-06 |
| CN1553911A (zh) | 2004-12-08 |
| EP1377577B1 (en) | 2006-06-14 |
| RU2003122364A (ru) | 2005-03-27 |
| NO20033290L (no) | 2003-09-11 |
| CN100371336C (zh) | 2008-02-27 |
| AR032511A1 (es) | 2003-11-12 |
| DE60212357T2 (de) | 2007-05-31 |
| PE20030197A1 (es) | 2003-03-12 |
| EP1377577A1 (en) | 2004-01-07 |
| MXPA03006515A (es) | 2003-10-15 |
| HUP0302807A2 (hu) | 2003-12-29 |
| DE60212357D1 (de) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A(S) 8A E 9A ANUIDADE(S) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |