BR0201004A - Compostos de triazina úteis como inibidores de sorbitol desidrogenase - Google Patents
Compostos de triazina úteis como inibidores de sorbitol desidrogenaseInfo
- Publication number
- BR0201004A BR0201004A BR0201004-6A BR0201004A BR0201004A BR 0201004 A BR0201004 A BR 0201004A BR 0201004 A BR0201004 A BR 0201004A BR 0201004 A BR0201004 A BR 0201004A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetic
- inhibitor
- compounds
- sorbitol dehydrogenase
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTOS DE TRIAZINA úTEIS COMO INIBIDORES DE SORBITOL DESIDROGENASE". Esta invenção refere-se a compostos inibidores de sorbitol desidrogenase com a fórmula I em que R^ 1^, R^ 2^ e R^ 3^ são tal como se define na memória descritiva. Esta invenção também refere-se a composições farmacêuticas contendo estes compostos, que inibem a sorbitol desidrogenase e a métodos de tratar ou de impedir complicações diabéticas, em especial a neuropatia diabética, a retinopatia diabética, a nefropatia diabética, a microangiopatia diabética, a macroangiopatia diabética, a cardiomiopatia diabética, e as úlceras nos pés, pela administração de tais compostos a um mamífero que sofra de diabetes e que esteja portanto em risco de vir a sofrer dessas complicações. Esta invenção também refere-se a composições farmacêuticas que incluam uma combinação de um composto com a fórmula I da invenção presente com um segundo agente farmacêutico, incluindo um inibidor de aldose reductase, um inibidor de permuta iónica de sódio hidrogênio (NHE-1), um inibidor de glicogêneo fosforilase (GPI), um inibidor seletivo de reabsorção de serotonina, um inibidor de 3-hidróxi-3-metilglutarilcoenzima A reductase, um inibidor do enzima de conversão de angiotensina, um agente anti-diabético de tiazolidinadiona, um antagonista de receptor de angiotensina II, um agonista de ácido <sym>-aminobutírico (GABA), um antagonista de fosfodiesterase de tipo 5, um agonista da adenosina, e um inibidor de CETP, e a métodos de utilizar estas composições de combinação.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28005001P | 2001-03-30 | 2001-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0201004A true BR0201004A (pt) | 2003-01-07 |
Family
ID=23071429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0201004-6A BR0201004A (pt) | 2001-03-30 | 2002-03-28 | Compostos de triazina úteis como inibidores de sorbitol desidrogenase |
Country Status (6)
Country | Link |
---|---|
US (1) | US6894047B2 (pt) |
EP (1) | EP1247809A3 (pt) |
JP (1) | JP2002326987A (pt) |
BR (1) | BR0201004A (pt) |
CA (1) | CA2379791A1 (pt) |
MX (1) | MXPA02003323A (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0934061T6 (en) | 1996-07-24 | 2015-01-26 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
JP2007534624A (ja) * | 2003-07-16 | 2007-11-29 | ニューロジェン・コーポレーション | ビアリールピペラジニル−ピリジン類縁体 |
EP1670446A2 (en) * | 2003-09-26 | 2006-06-21 | Japan Tobacco Inc. | Method of inhibiting remnant lipoprotein production |
WO2005037284A1 (en) * | 2003-10-15 | 2005-04-28 | Pfizer Products Inc. | Sorbitol dehydrogenase inhibitor and hypertensive agent combinations |
CA2568640C (en) | 2004-06-04 | 2011-08-09 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing irbesartan |
MY145822A (en) * | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
WO2008072850A1 (en) * | 2006-12-11 | 2008-06-19 | Amorepacific Corporation | Triazine derivatives having inhibitory activity against acetyl-coa carboxylase |
SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
FR2948027A1 (fr) | 2009-07-17 | 2011-01-21 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion |
US11083720B2 (en) | 2017-03-17 | 2021-08-10 | Regents Of The University Of Colorado, A Body Corporate | Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670551B2 (de) * | 1965-10-30 | 1973-01-25 | Salze trisubstituierter s-triazine | |
DE178901C (pt) * | 1968-02-08 | |||
DE3905364A1 (de) * | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
DE4025387A1 (de) * | 1990-08-10 | 1992-02-13 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien |
CA2145640C (en) * | 1992-09-28 | 2001-01-30 | Banavara L. Mylari | Substituted pyrimidines for control of diabetic complications |
AP2005003199A0 (en) * | 1999-04-01 | 2005-03-31 | Pfizer Prod Inc | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
EP1041068B1 (en) * | 1999-04-01 | 2004-04-14 | Pfizer Products Inc. | Compounds for treating and preventing diabetic complications |
AU3977001A (en) * | 2000-02-15 | 2001-08-27 | Sugen Inc | Pyrrole substituted 2-indolinone protein kinase inhibitors |
-
2002
- 2002-03-22 EP EP02252062A patent/EP1247809A3/en not_active Withdrawn
- 2002-03-26 US US10/107,763 patent/US6894047B2/en not_active Expired - Fee Related
- 2002-03-27 JP JP2002087629A patent/JP2002326987A/ja active Pending
- 2002-03-27 MX MXPA02003323A patent/MXPA02003323A/es unknown
- 2002-03-28 BR BR0201004-6A patent/BR0201004A/pt not_active IP Right Cessation
- 2002-03-28 CA CA002379791A patent/CA2379791A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1247809A2 (en) | 2002-10-09 |
JP2002326987A (ja) | 2002-11-15 |
US20030004166A1 (en) | 2003-01-02 |
CA2379791A1 (en) | 2002-09-30 |
MXPA02003323A (es) | 2002-11-05 |
EP1247809A3 (en) | 2003-12-17 |
US6894047B2 (en) | 2005-05-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1980 DE 16/12/2008. |