BR0116330A - Inibidores da interação e2f-1/ciclina para terapia de câncer - Google Patents
Inibidores da interação e2f-1/ciclina para terapia de câncerInfo
- Publication number
- BR0116330A BR0116330A BR0116330-2A BR0116330A BR0116330A BR 0116330 A BR0116330 A BR 0116330A BR 0116330 A BR0116330 A BR 0116330A BR 0116330 A BR0116330 A BR 0116330A
- Authority
- BR
- Brazil
- Prior art keywords
- mer
- cap
- cyclin
- cancer therapy
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
"INIBIDORES DA INTERAçãO E2F-1/CICLINA PARA TERAPIA DE CâNCER". Os compostos da invenção têm as fórmulas estruturais gerais lad. Os compostos da presente invenção referem-se a peptídeos de 8-mer, 7mer, 6-mer e S-mer tendo as seq³ências de amino ácido que seguem, e são referidos coletivamente como tendo "Fórmulas la-d": Cap-AA8-AA7-AA6-AA5-AA4*-AA3-AA2-AA1 8-mer la Cap-AA7-AA6-AA5-AA4*-AA3-AA2-AA1 7-mer lb Cap-AA6-AAS-AA4*-AA3-AA2-AA1 6-mer lc Cap-AAS-AA4*-AA3-AA2-AA1 * 5-mer ld ou um seu sal ou seu éster farmaceuticamente aceitável, que inibem a interação do fator de transcrição E2F-1 com a Ciclina A. Como um antagonista da interação E2F-1/Ciclina A, os compostos da presente invenção podem ser usados no tratamento de câncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25682800P | 2000-12-20 | 2000-12-20 | |
PCT/EP2001/015006 WO2002050102A2 (en) | 2000-12-20 | 2001-12-19 | Inhibitors of the e2f-1/cyclin interaction for cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0116330A true BR0116330A (pt) | 2004-02-25 |
Family
ID=22973745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0116330-2A BR0116330A (pt) | 2000-12-20 | 2001-12-19 | Inibidores da interação e2f-1/ciclina para terapia de câncer |
Country Status (8)
Country | Link |
---|---|
US (1) | US20020142966A1 (pt) |
EP (1) | EP1345957A2 (pt) |
JP (1) | JP2004516301A (pt) |
CN (1) | CN1592752A (pt) |
AU (1) | AU2002234591A1 (pt) |
BR (1) | BR0116330A (pt) |
CA (1) | CA2432031A1 (pt) |
WO (1) | WO2002050102A2 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7449544B2 (en) * | 1999-11-30 | 2008-11-11 | Cyclacel Limited | p21 peptides |
WO2003063910A2 (en) * | 2002-01-28 | 2003-08-07 | Novartis Ag | β-HOMOLYSINE CONJUGATES AND THEIR USE AS TRANSPORT ENHANCER |
US20110262965A1 (en) | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
EA017179B1 (ru) * | 2011-04-06 | 2012-10-30 | Ооо "Метамакс" | Фармацевтическая композиция для лечения гиперпролиферативных заболеваний и её применение |
EP3658567A1 (en) | 2017-07-28 | 2020-06-03 | Circle Pharma, Inc. | Cyclative release of peptidic compounds |
CN112608367B (zh) * | 2021-03-08 | 2021-06-11 | 暨南大学 | 一种非天然氨基酸短肽及其在抗肿瘤中的应用 |
US20240218021A1 (en) * | 2022-10-21 | 2024-07-04 | Circle Pharma, Inc. | Cyclin inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7676894A (en) * | 1993-08-27 | 1995-03-21 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Convection-enhanced drug delivery |
US5625031A (en) * | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
US5719296A (en) * | 1995-10-30 | 1998-02-17 | Merck & Co., Inc. | Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins |
GB9928323D0 (en) * | 1999-11-30 | 2000-01-26 | Cyclacel Ltd | Peptides |
-
2001
- 2001-12-19 CN CNA018210104A patent/CN1592752A/zh active Pending
- 2001-12-19 JP JP2002551995A patent/JP2004516301A/ja active Pending
- 2001-12-19 CA CA002432031A patent/CA2432031A1/en not_active Abandoned
- 2001-12-19 BR BR0116330-2A patent/BR0116330A/pt not_active IP Right Cessation
- 2001-12-19 AU AU2002234591A patent/AU2002234591A1/en not_active Abandoned
- 2001-12-19 EP EP01985424A patent/EP1345957A2/en not_active Withdrawn
- 2001-12-19 US US10/024,935 patent/US20020142966A1/en not_active Abandoned
- 2001-12-19 WO PCT/EP2001/015006 patent/WO2002050102A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2002050102A3 (en) | 2003-03-13 |
AU2002234591A1 (en) | 2002-07-01 |
CA2432031A1 (en) | 2002-06-27 |
EP1345957A2 (en) | 2003-09-24 |
JP2004516301A (ja) | 2004-06-03 |
US20020142966A1 (en) | 2002-10-03 |
CN1592752A (zh) | 2005-03-09 |
WO2002050102A2 (en) | 2002-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP056194A (es) | Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de quinasa | |
PA8569201A1 (es) | "derivados de bencimidazol n3 alquilado como inhibidores de mek" "n3 alkylated benzimimidazole derivatives as mek inhibitors" | |
ECSP056246A (es) | DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA | |
SG2013013339A (en) | N3 alkylated benzimidazole derivatives as mek inhibitors | |
BR0113496A (pt) | Composto ou um sal farmaceuticamente aceitável ou ester hidrolisável in vivo deste, uso destes, método para produzir um efeito inibidor do ciclo celular (anti-proliferação celular) em um animal de sangue quente, e, composição farmacêutica | |
EA200300354A1 (ru) | Хинолиноновые производные в качестве ингибиторов тирозинкиназы | |
EA200201271A1 (ru) | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 | |
ES2534303T3 (es) | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN | |
CY1114944T1 (el) | Σταθεροποιημενα αλφα ελικοειδη πεπτιδια και χρησεις αυτων | |
CY1106283T1 (el) | Κινολινυλ-πυρρολοπυραζολες | |
BRPI0409516A (pt) | composição, uso de uma composição e processo de melhora da penetração de um ativo farmacêutico | |
PA8432901A1 (es) | Compuestos de piridilpirrol | |
CY1109843T1 (el) | Αναλογα της βιταμινης d | |
DE69833010D1 (de) | Cannabinol-11-säurederivate als entzündungshemmer und analgetika | |
BRPI0517843A (pt) | compostos de moléculas conjugadas com a atividade de absorção de células aumentada | |
BRPI0409627A (pt) | 2-hidróxi-3-diaminoalcanos de fenacila | |
AR018501A1 (es) | Derivados de la dolastatina 15 | |
TW200930412A (en) | Topical compositions comprising non-proteogenic amino acids and methods of treating skin | |
BR0116330A (pt) | Inibidores da interação e2f-1/ciclina para terapia de câncer | |
TR200400228T4 (tr) | Psöryazinin tedavisinde kullanılacak maddeler | |
Santoro et al. | Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β‐Amyloid Toxicity | |
ATE279410T1 (de) | 3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen | |
BRPI0416882A (pt) | composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto | |
BRPI0413384A (pt) | inibidores da proteìna farnesil transferase como agentes antitumores | |
BR0010255A (pt) | Formulação farmacêutica, kit de partes, método para tratamento de um paciente sofrendo de ou susceptìvel a uma condição em que a inibição da trombina e/ou inibição da carboxipeptidase u são requeridas ou desejadas, e, uso de uma formulação |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS. |