BR0116330A - Inibidores da interação e2f-1/ciclina para terapia de câncer - Google Patents

Inibidores da interação e2f-1/ciclina para terapia de câncer

Info

Publication number
BR0116330A
BR0116330A BR0116330-2A BR0116330A BR0116330A BR 0116330 A BR0116330 A BR 0116330A BR 0116330 A BR0116330 A BR 0116330A BR 0116330 A BR0116330 A BR 0116330A
Authority
BR
Brazil
Prior art keywords
mer
cap
cyclin
cancer therapy
compounds
Prior art date
Application number
BR0116330-2A
Other languages
English (en)
Inventor
Kenneth Walter Bair
Ying-Nan Pan Chen
Timothy Michael Ramsey
Michael Lloyd Sabio
Sushil Kumar Sharma
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0116330A publication Critical patent/BR0116330A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"INIBIDORES DA INTERAçãO E2F-1/CICLINA PARA TERAPIA DE CâNCER". Os compostos da invenção têm as fórmulas estruturais gerais lad. Os compostos da presente invenção referem-se a peptídeos de 8-mer, 7mer, 6-mer e S-mer tendo as seq³ências de amino ácido que seguem, e são referidos coletivamente como tendo "Fórmulas la-d": Cap-AA8-AA7-AA6-AA5-AA4*-AA3-AA2-AA1 8-mer la Cap-AA7-AA6-AA5-AA4*-AA3-AA2-AA1 7-mer lb Cap-AA6-AAS-AA4*-AA3-AA2-AA1 6-mer lc Cap-AAS-AA4*-AA3-AA2-AA1 * 5-mer ld ou um seu sal ou seu éster farmaceuticamente aceitável, que inibem a interação do fator de transcrição E2F-1 com a Ciclina A. Como um antagonista da interação E2F-1/Ciclina A, os compostos da presente invenção podem ser usados no tratamento de câncer.
BR0116330-2A 2000-12-20 2001-12-19 Inibidores da interação e2f-1/ciclina para terapia de câncer BR0116330A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25682800P 2000-12-20 2000-12-20
PCT/EP2001/015006 WO2002050102A2 (en) 2000-12-20 2001-12-19 Inhibitors of the e2f-1/cyclin interaction for cancer therapy

Publications (1)

Publication Number Publication Date
BR0116330A true BR0116330A (pt) 2004-02-25

Family

ID=22973745

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116330-2A BR0116330A (pt) 2000-12-20 2001-12-19 Inibidores da interação e2f-1/ciclina para terapia de câncer

Country Status (8)

Country Link
US (1) US20020142966A1 (pt)
EP (1) EP1345957A2 (pt)
JP (1) JP2004516301A (pt)
CN (1) CN1592752A (pt)
AU (1) AU2002234591A1 (pt)
BR (1) BR0116330A (pt)
CA (1) CA2432031A1 (pt)
WO (1) WO2002050102A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
JP2005526023A (ja) * 2002-01-28 2005-09-02 ノバルティス アクチエンゲゼルシャフト β−ホモリジンコンジュゲートおよび輸送エンハンサーとしてのそれらの使用
US20110262965A1 (en) 2010-04-23 2011-10-27 Life Technologies Corporation Cell culture medium comprising small peptides
EA201100464A1 (ru) * 2011-04-06 2012-10-30 Ооо "Метамакс" (Ооо "Метамах") Фармацевтическая композиция для лечения гиперпролиферативных заболеваний и её применение
US11299513B2 (en) 2017-07-28 2022-04-12 Circle Pharma, Inc. Cyclative release of peptidic compounds
CN112608367B (zh) * 2021-03-08 2021-06-11 暨南大学 一种非天然氨基酸短肽及其在抗肿瘤中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005864A1 (en) * 1993-08-27 1995-03-02 Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Convection-enhanced drug delivery
US5625031A (en) * 1994-02-08 1997-04-29 Bristol-Myers Squibb Company Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
GB9928323D0 (en) * 1999-11-30 2000-01-26 Cyclacel Ltd Peptides

Also Published As

Publication number Publication date
EP1345957A2 (en) 2003-09-24
WO2002050102A2 (en) 2002-06-27
CN1592752A (zh) 2005-03-09
CA2432031A1 (en) 2002-06-27
WO2002050102A3 (en) 2003-03-13
US20020142966A1 (en) 2002-10-03
AU2002234591A1 (en) 2002-07-01
JP2004516301A (ja) 2004-06-03

Similar Documents

Publication Publication Date Title
ECSP056194A (es) Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de quinasa
PA8569201A1 (es) "derivados de bencimidazol n3 alquilado como inhibidores de mek" "n3 alkylated benzimimidazole derivatives as mek inhibitors"
ECSP056246A (es) DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA
SG2013013339A (en) N3 alkylated benzimidazole derivatives as mek inhibitors
BR0113496A (pt) Composto ou um sal farmaceuticamente aceitável ou ester hidrolisável in vivo deste, uso destes, método para produzir um efeito inibidor do ciclo celular (anti-proliferação celular) em um animal de sangue quente, e, composição farmacêutica
EA200300354A1 (ru) Хинолиноновые производные в качестве ингибиторов тирозинкиназы
EA200201271A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
ES2534303T3 (es) Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
CY1114944T1 (el) Σταθεροποιημενα αλφα ελικοειδη πεπτιδια και χρησεις αυτων
CY1106283T1 (el) Κινολινυλ-πυρρολοπυραζολες
BRPI0409516A (pt) composição, uso de uma composição e processo de melhora da penetração de um ativo farmacêutico
PA8432901A1 (es) Compuestos de piridilpirrol
CY1109843T1 (el) Αναλογα της βιταμινης d
BRPI0517843A (pt) compostos de moléculas conjugadas com a atividade de absorção de células aumentada
DE69833010D1 (de) Cannabinol-11-säurederivate als entzündungshemmer und analgetika
BRPI0409627A (pt) 2-hidróxi-3-diaminoalcanos de fenacila
AR018501A1 (es) Derivados de la dolastatina 15
EA199700380A1 (ru) Бициклические ароматические соединения, фармацевтическая и косметическая композиции на их основе и применение косметической композиции
TW200930412A (en) Topical compositions comprising non-proteogenic amino acids and methods of treating skin
TR200400228T4 (tr) Psöryazinin tedavisinde kullanılacak maddeler
BR0116330A (pt) Inibidores da interação e2f-1/ciclina para terapia de câncer
Santoro et al. Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β‐Amyloid Toxicity
EA199700381A1 (ru) Диароматические соединения пропинила или диенила, промежуточные соединения, фармацевтические и косметические композиции на основе указанных соединений и применение косметических композиций
BRPI0413384A (pt) inibidores da proteìna farnesil transferase como agentes antitumores
ATE505199T1 (de) Pharmazeutische, kosmetische oder therapeutische zusammensetzungen enthaltend peptide mit dem motiv arg-gly-ser

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS.