BR0116312A - Métodos e composições para proteção e restauração da pele empregando inibidores de mmp seletivos - Google Patents

Métodos e composições para proteção e restauração da pele empregando inibidores de mmp seletivos

Info

Publication number
BR0116312A
BR0116312A BR0116312-4A BR0116312A BR0116312A BR 0116312 A BR0116312 A BR 0116312A BR 0116312 A BR0116312 A BR 0116312A BR 0116312 A BR0116312 A BR 0116312A
Authority
BR
Brazil
Prior art keywords
mmp
skin
restoration
collagen
compositions
Prior art date
Application number
BR0116312-4A
Other languages
English (en)
Inventor
James Varani
Gary J Fisher
John J Voorhees
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of BR0116312A publication Critical patent/BR0116312A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

"MéTODOS E COMPOSIçõES PARA PROTEçãO E RESTAURAçãO DA PELE EMPREGANDO INIBIDORES DE MMP SELETIVOS". A invenção é com base na inibição seletiva da enzima de de-gradação do colágeno MMP-1, que causa a danificação da matriz dérmica em humanos, ao mesmo tempo em que poupando as enzimas MMP-9 e eventualmente MMP-2, que não somente não causa danos (com base na extrapolação de nosso sistema de colágeno in vitro para pele real) porém realmente "supera" a danificação produzida por MMP-1 para restaurar a função normal da pele. A metaloproteinase- 1 de matriz (MMP 1, colagenase do fibroblasto) é induzida pela radiação UV do sol e é naturalmente elevada na velhice. Os fibroblastos humanos se expõem a produtos de degradação do colágeno de contração MMP-1, porém quando esse fragmento é removido do seu ambiente, os fibroblastos comportam-se normalmente. A inibição de MMP-1 porém poupa (ou inibi por uma extensão muito menor) enzimas que removem os fragmentos, melhora a pele humana após o ataque violento da radiação UV solar, velhice e acne.
BR0116312-4A 2000-12-18 2001-12-18 Métodos e composições para proteção e restauração da pele empregando inibidores de mmp seletivos BR0116312A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/740,242 US20020119107A1 (en) 2000-12-18 2000-12-18 Method for protecting and restoring skin using selective MMP inhibitors
PCT/US2001/048636 WO2002049605A2 (en) 2000-12-18 2001-12-18 Methods and compositions for protecting and restoring skin using selective mmp inhibitors

Publications (1)

Publication Number Publication Date
BR0116312A true BR0116312A (pt) 2004-03-02

Family

ID=24975645

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116312-4A BR0116312A (pt) 2000-12-18 2001-12-18 Métodos e composições para proteção e restauração da pele empregando inibidores de mmp seletivos

Country Status (8)

Country Link
US (1) US20020119107A1 (pt)
EP (1) EP1343470A2 (pt)
JP (1) JP2004536781A (pt)
AU (1) AU2002235215A1 (pt)
BR (1) BR0116312A (pt)
CA (1) CA2432265A1 (pt)
MX (1) MXPA03005421A (pt)
WO (1) WO2002049605A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10341663A1 (de) * 2003-09-08 2005-04-07 Beiersdorf Ag Haut- und/oder Haarmittel enthaltend 4-fach substituierte Cyclohexen-Verbindungen
CA2629529A1 (en) * 2004-11-18 2006-05-26 Biopharmacopae Design International Inc. Plant extracts and dermatological uses thereof
ATE532529T1 (de) * 2005-05-13 2011-11-15 Nestec Sa Herstellung von glucosamin aus pflanzenspezies
CN101175502B (zh) * 2005-05-13 2012-02-08 雀巢技术公司 由植物物种制备葡糖胺
US20070004036A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for keratinocyte culture
US20070128685A1 (en) * 2005-07-01 2007-06-07 Rodolfo Faudoa Methods and compositions for cell culture
US20070003541A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for therapeutics
KR100803577B1 (ko) * 2005-11-30 2008-02-15 (주)아모레퍼시픽 이카린의 가수분해물을 함유하는 화장료용 조성물
EP1818058A3 (en) * 2006-02-13 2007-11-07 Astion Pharma A/S Treatment of mmp-mediated dermatological diseases with pemirolast
MY183215A (en) 2013-11-05 2021-02-18 Nestle Sa Generation of glucosamine from plant material
CN104146939A (zh) * 2014-08-15 2014-11-19 马应龙药业集团股份有限公司 一种护臀膏及其制备方法
WO2022128057A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for prevention and treatment of collagen degradation in human connecting tissue

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652227A (en) * 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals
US5837224A (en) * 1996-01-19 1998-11-17 The Regents Of The University Of Michigan Method of inhibiting photoaging of skin
DE69828620T2 (de) * 1997-02-25 2005-12-01 The Regents Of The University Of Michigan, Ann Arbor Verfahren und zusammensetzungen zur vorbeugung und behandlung der chronologischer alterung der menschliches haut
GB9708133D0 (en) * 1997-04-22 1997-06-11 British Biotech Pharm Novel use of matrix metalloproteinase inhibitors
TWI234467B (en) * 1997-06-04 2005-06-21 Univ Michigan Composition for inhibiting photoaging of skin
AU6843598A (en) * 1998-03-25 1999-10-18 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US6683069B1 (en) * 1998-04-02 2004-01-27 Regents Of The University Of Michigan Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin

Also Published As

Publication number Publication date
EP1343470A2 (en) 2003-09-17
WO2002049605A3 (en) 2003-03-06
WO2002049605A2 (en) 2002-06-27
AU2002235215A1 (en) 2002-07-01
MXPA03005421A (es) 2004-05-04
US20020119107A1 (en) 2002-08-29
JP2004536781A (ja) 2004-12-09
CA2432265A1 (en) 2002-06-27

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 8/64 (2006.01), A61K 8/36 (2006.01), A61K 8/4