BR0115042A - Ligandos de receptores de aminoalquilpirrolidina serotonina e composições, seus usos farmacêuticos, e processos para a sua sìntese - Google Patents

Ligandos de receptores de aminoalquilpirrolidina serotonina e composições, seus usos farmacêuticos, e processos para a sua sìntese

Info

Publication number
BR0115042A
BR0115042A BR0115042-1A BR0115042A BR0115042A BR 0115042 A BR0115042 A BR 0115042A BR 0115042 A BR0115042 A BR 0115042A BR 0115042 A BR0115042 A BR 0115042A
Authority
BR
Brazil
Prior art keywords
receptor ligands
aminoalkylpyrrolidine
serotonin
compositions
synthesis
Prior art date
Application number
BR0115042-1A
Other languages
English (en)
Inventor
Yuanjin Rui
Atsuo Kuki
Yufeng Hong
Zhengwei Peng
David Robert Luthin
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0115042A publication Critical patent/BR0115042A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"LIGANDOS DE RECEPTORES DE AMINOALQUILPIRROLIDINA SEROTONINA E COMPOSIçõES, SEUS USOS FARMACêUTICOS, E PROCESSOS PARA A SUA SìNTESE". Ligandos de receptores de aminoalquilpirrolidina 5-HT~ 7~, métodos de preparação de tais ligandos, compostos intermediários úteis na preparação dos ligandos do receptor, composições farmacêuticas compreendendo os ligandos do receptor, e métodos de tratamento de distúrbios de sono, dor, depressão, e esquizofrenia utilizando os ligandos do receptor são revelados. Os ligandos do receptor têm a fórmula (1), em que as variáveis da fórmula são como definido aqui, e seus sais, solvatos, metabólitos ativos, ou pró-drogas farmaceuticamente aceitáveis.
BR0115042-1A 2000-10-30 2001-10-26 Ligandos de receptores de aminoalquilpirrolidina serotonina e composições, seus usos farmacêuticos, e processos para a sua sìntese BR0115042A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24371000P 2000-10-30 2000-10-30
PCT/IB2001/002023 WO2002036560A1 (en) 2000-10-30 2001-10-26 Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis

Publications (1)

Publication Number Publication Date
BR0115042A true BR0115042A (pt) 2004-02-03

Family

ID=22919809

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115042-1A BR0115042A (pt) 2000-10-30 2001-10-26 Ligandos de receptores de aminoalquilpirrolidina serotonina e composições, seus usos farmacêuticos, e processos para a sua sìntese

Country Status (11)

Country Link
US (2) US20040039044A1 (pt)
EP (1) EP1339677B1 (pt)
JP (1) JP2004517058A (pt)
AT (1) ATE315023T1 (pt)
AU (1) AU2001295837A1 (pt)
BR (1) BR0115042A (pt)
CA (1) CA2425286A1 (pt)
DE (1) DE60116517T2 (pt)
ES (1) ES2251514T3 (pt)
MX (1) MXPA03002595A (pt)
WO (1) WO2002036560A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1300108C (zh) * 2004-12-29 2007-02-14 浙江大学 1－甲基－2－胺乙基吡咯烷的合成方法
EP1875899A1 (en) * 2006-06-29 2008-01-09 Laboratorios Del Dr. Esteve, S.A. Use of 5HT7 receptor agonists for the treatment of pain
WO2011083487A1 (en) * 2010-01-05 2011-07-14 Suven Life Sciences Limited Sulfone compounds as 5-ht6 receptor ligands
AR080374A1 (es) * 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
WO2020260526A1 (en) * 2019-06-26 2020-12-30 Enyo Pharma Tertiary amine derivatives and their uses for treating a viral infection
CN111960983A (zh) * 2020-08-31 2020-11-20 南通大学 一种n-甲基-3-(1-甲基吡咯烷-3-基)丙-1-胺及其合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584800A (pt) * 1968-09-09 1970-01-02
IL36728A0 (en) * 1970-05-14 1971-06-23 Richardson Merrell Inc Substituted pyrrolylmethylamines and their preparation
FR2319337A1 (fr) * 1975-07-30 1977-02-25 Fabre Sa Pierre Gem diaryles possedant une activite antiarythmique utile en therapeutique cardiovasculaire
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
US5571832A (en) * 1992-11-13 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Nitrogen-containing cyclohetero alkylamino aryl derivatives for CNS disorders
AU2960599A (en) * 1998-03-30 1999-10-18 Akira Karasawa Quinazoline derivatives
AU6621600A (en) * 1999-08-04 2001-03-05 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US6699873B1 (en) * 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
AU2868601A (en) * 2000-01-27 2001-08-07 Ribotargets Ltd Biaryl compounds, their preparation and their use in therapy

Also Published As

Publication number Publication date
EP1339677A1 (en) 2003-09-03
DE60116517T2 (de) 2006-08-17
US20060063932A1 (en) 2006-03-23
AU2001295837A1 (en) 2002-05-15
US20040039044A1 (en) 2004-02-26
DE60116517D1 (de) 2006-03-30
CA2425286A1 (en) 2002-05-10
WO2002036560A1 (en) 2002-05-10
ATE315023T1 (de) 2006-02-15
EP1339677B1 (en) 2006-01-04
ES2251514T3 (es) 2006-05-01
JP2004517058A (ja) 2004-06-10
MXPA03002595A (es) 2003-06-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A , 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009.