BR0114603A - M-Amino-phenylimino-imidazolidine derivatives for the treatment of urinary incontinence - Google Patents

M-Amino-phenylimino-imidazolidine derivatives for the treatment of urinary incontinence

Info

Publication number
BR0114603A
BR0114603A BR0114603-3A BR0114603A BR0114603A BR 0114603 A BR0114603 A BR 0114603A BR 0114603 A BR0114603 A BR 0114603A BR 0114603 A BR0114603 A BR 0114603A
Authority
BR
Brazil
Prior art keywords
urinary incontinence
amino
treatment
phenylimino
imidazolidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
BR0114603-3A
Other languages
Portuguese (pt)
Inventor
Pascale Pouzet
Franz Esser
Hisato Kitagawa
Kenji Sakai
Ikunobu Muramatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BR0114603A publication Critical patent/BR0114603A/en
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE M-AMINO-FENILIMINOIMIDAZOLIDINA PARA TRATAMENTO DA INCONTINêNCIA URINáRIA". A presente invenção refere-se aos derivados de m-aminofenilimino-imidazolidina com novas amostras de substituintes no anel fenila, de fórmula geral (I) ou de fórmula geral (II) com R~ 1~: F, CI, Br, CH~ 2~H, CF2H ou CF~ 3~; R~ 2~: NR~ 6~R~ 7~, com R~ 6~: Me, Et, Pr ou iPr, R~ 7~: Me, Et ou Pr, R~ 3~, R~ 4~, R~ 5~: são respectivamente independentemente um do outro H, Me, F, CI, Br, CH~ 2~F, CF~ 2~H, e/ou CF~ 3~ e, para o caso de R~ 4~ ser Me, F, CI, Br, CH~ 2~F, CF~ 2~H ou CF~ 3~ então R~ 1~ é adicionalmente também H, ou Me e/ou seu sal farmacologicamente compatível, a seu emprego para preparação de medicamentos, particularmente para tratamento da incontinência urinária, e processo para preparação do mesmo."M-AMINO-PHENYLIMINOIMIDAZOLIDINE DERIVATIVES FOR TREATMENT OF URINARY INCONTINENCE". The present invention relates to m-aminophenylimino-imidazolidine derivatives having new phenyl ring substituent samples of formula (I) or formula (II) having R1: F, CI, Br, CH2 2 H, CF 2 H or CF 3; R ~ 2 ~: NR ~ 6 ~ R ~ 7 ~, with R ~ 6 ~: Me, Et, Pr or iPr, R ~ 7 ~: Me, Et or Pr, R ~ 3 ~, R ~ 4 ~, R ~ 5 ~: are respectively independently of each other H, Me, F, CI, Br, CH ~ 2 ~ F, CF ~ 2 ~ H, and / or CF ~ 3 ~ and, in case R ~ 4 ~ is Me, F, CI, Br, CH ~ 2 ~ F, CF ~ 2 ~ H or CF ~ 3 ~ so R ~ 1 ~ is additionally also H, or Me and / or its pharmacologically compatible salt, for use in preparing them. medicines, particularly for treating urinary incontinence, and the process for preparing it.

BR0114603-3A 2000-10-14 2001-10-11 M-Amino-phenylimino-imidazolidine derivatives for the treatment of urinary incontinence Expired - Fee Related BR0114603A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10051005 2000-10-14
PCT/EP2001/011764 WO2002032876A2 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence

Publications (1)

Publication Number Publication Date
BR0114603A true BR0114603A (en) 2003-10-14

Family

ID=7659815

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114603-3A Expired - Fee Related BR0114603A (en) 2000-10-14 2001-10-11 M-Amino-phenylimino-imidazolidine derivatives for the treatment of urinary incontinence

Country Status (23)

Country Link
EP (1) EP1328517A2 (en)
JP (1) JP2004511547A (en)
KR (1) KR20030046503A (en)
CN (1) CN1471514A (en)
AR (1) AR035923A1 (en)
AU (1) AU2002215943A1 (en)
BG (1) BG107711A (en)
BR (1) BR0114603A (en)
CA (1) CA2425563A1 (en)
CZ (1) CZ20031333A3 (en)
DE (1) DE10150312A1 (en)
EA (1) EA200300460A1 (en)
EC (1) ECSP034517A (en)
EE (1) EE200300177A (en)
HU (1) HUP0302245A3 (en)
IL (1) IL155338A0 (en)
MX (1) MXPA03003162A (en)
NO (1) NO20031697L (en)
PL (1) PL361359A1 (en)
SK (1) SK4342003A3 (en)
WO (1) WO2002032876A2 (en)
YU (1) YU28203A (en)
ZA (1) ZA200302345B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4168086B1 (en) * 2008-04-16 2008-10-22 国立大学法人福井大学 Imidazoline derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2806811A1 (en) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINE, THEIR ACID-ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR MANUFACTURING THE SAME
CA1201066A (en) * 1981-11-20 1986-02-25 Alcon Laboratories, Inc. N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure
DE19514579A1 (en) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Use of alpha-1-olone agonists for the treatment of urinary incontinence

Also Published As

Publication number Publication date
MXPA03003162A (en) 2004-12-06
NO20031697L (en) 2003-05-26
KR20030046503A (en) 2003-06-12
SK4342003A3 (en) 2003-10-07
YU28203A (en) 2006-05-25
CA2425563A1 (en) 2002-04-25
EE200300177A (en) 2003-08-15
PL361359A1 (en) 2004-10-04
EP1328517A2 (en) 2003-07-23
AR035923A1 (en) 2004-07-28
JP2004511547A (en) 2004-04-15
CN1471514A (en) 2004-01-28
IL155338A0 (en) 2003-11-23
CZ20031333A3 (en) 2003-08-13
WO2002032876A3 (en) 2002-07-18
ECSP034517A (en) 2003-04-25
BG107711A (en) 2004-02-27
WO2002032876A2 (en) 2002-04-25
HUP0302245A2 (en) 2003-10-28
EA200300460A1 (en) 2004-02-26
AU2002215943A1 (en) 2002-04-29
DE10150312A1 (en) 2002-07-04
NO20031697D0 (en) 2003-04-11
HUP0302245A3 (en) 2004-01-28
ZA200302345B (en) 2004-04-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS.