BR0113188A - Application of perfluoroalkyl-containing metal complexes as contrast agents in magnetic resonance imaging for the identification of plaques, tumors and necroses - Google Patents
Application of perfluoroalkyl-containing metal complexes as contrast agents in magnetic resonance imaging for the identification of plaques, tumors and necrosesInfo
- Publication number
- BR0113188A BR0113188A BR0113188-5A BR0113188A BR0113188A BR 0113188 A BR0113188 A BR 0113188A BR 0113188 A BR0113188 A BR 0113188A BR 0113188 A BR0113188 A BR 0113188A
- Authority
- BR
- Brazil
- Prior art keywords
- perfluoroalkyl
- magnetic resonance
- application
- identification
- necroses
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
"APLICAçãO DE COMPLEXOS DE METAL CONTENDO PERFLUOROALQUILA COMO AGENTES DE CONTRASTE NA IMAGEM DE RESSONâNCIA MAGNéTICA PARA A IDENTIFICAçãO DE PLACAS, TUMORES E NECROSES". A invenção refere-se à aplicação de complexos de metal contendo perfluoroalquila, que apresentam uma concentração de formação de micélio crítica <10^ -3^ mol/l, u diâmetro de micélio hidrodinâmico (2 Rh)> 1 nm e uma "relaxivity" de prótons no plasma (R^ 1^) > 10 l/mmoles.s, como agentes de contraste na imagem de ressonância magnética, tanto para a identificação de placas, gânglios linfáticos, tecido infartado e necrosado como também para a identificação independente de tecido necrosado e tecido de tumor."APPLICATION OF METAL COMPLEX CONTAINING PERFluoroalkyl AS AGENTS OF CONTRAST IN MAGNETIC RESONANCE IMAGE FOR IDENTIFYING PLATES, TUMORS AND NECROSES". The invention relates to the application of perfluoroalkyl-containing metal complexes which have a critical mycelium formation concentration of <10 ^ -3 ^ mol / l, a hydrodynamic mycelium (2 Rh) diameter> 1 nm and a "relaxivity". of plasma protons (R ^ 1 ^)> 10 l / mmoles.s, as contrast agents in magnetic resonance imaging, both for the identification of plaques, lymph nodes, infarcted and necrotic tissue as well as for the independent identification of tissue necrotic and tumor tissue.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10040380A DE10040380B4 (en) | 2000-08-11 | 2000-08-11 | MRI contrast agent for visualization of plaque, lymph nodes, infarcted and necrotic tissue or both necrosis and tumors, comprising perfluoroalkylated metal complex having specific micelle forming properties |
PCT/EP2001/008498 WO2002013874A2 (en) | 2000-08-11 | 2001-07-23 | Use of metal complexes containing perfluoroalkyl as contrast agents in mr-imaging for the representation of plaques, tumours and necroses |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0113188A true BR0113188A (en) | 2003-06-24 |
Family
ID=7652860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0113188-5A BR0113188A (en) | 2000-08-11 | 2001-07-23 | Application of perfluoroalkyl-containing metal complexes as contrast agents in magnetic resonance imaging for the identification of plaques, tumors and necroses |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1307236A2 (en) |
JP (1) | JP2004506025A (en) |
KR (1) | KR20030022387A (en) |
CN (1) | CN1469757A (en) |
AR (1) | AR034139A1 (en) |
AU (2) | AU7754901A (en) |
BG (1) | BG107542A (en) |
BR (1) | BR0113188A (en) |
CA (1) | CA2419223A1 (en) |
CZ (1) | CZ2003392A3 (en) |
DE (1) | DE10066210B4 (en) |
EE (1) | EE200300061A (en) |
HR (1) | HRP20030173A2 (en) |
HU (1) | HUP0300736A3 (en) |
IL (1) | IL154385A0 (en) |
MX (1) | MXPA03001287A (en) |
NO (1) | NO20030604L (en) |
NZ (1) | NZ523932A (en) |
PL (1) | PL365596A1 (en) |
RU (1) | RU2290206C2 (en) |
SK (1) | SK1572003A3 (en) |
TW (1) | TWI296931B (en) |
UA (1) | UA82642C2 (en) |
WO (1) | WO2002013874A2 (en) |
YU (1) | YU10603A (en) |
ZA (1) | ZA200301949B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10231799B4 (en) * | 2002-07-10 | 2006-10-05 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast agents in MR imaging for the presentation of intravascular thrombi |
US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
DE102005008309A1 (en) * | 2005-02-17 | 2006-08-24 | Schering Ag | Pharmaceutical agents containing fluoroalkyl-containing metal complexes and epothilones |
DE102006021495A1 (en) * | 2006-05-09 | 2007-11-15 | Bayer Schering Pharma Ag | Use of metal chelate containing perfluorinated alkyl-residue, chelator-residue and metal ion equivalent to the atomic number, for the production of diagnostic agent for representation of amyloid-containing plaques |
US7887835B2 (en) * | 2006-09-19 | 2011-02-15 | Fujifilm Corporation | Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound |
DE102006049821A1 (en) * | 2006-10-18 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | New, well tolerated metal chelates, for use as radiodiagnostic, radiotherapeutic or NMR and X-ray diagnostic agents, contain chelator and perfluorinated polyethylene glycol residues |
DE102007015598A1 (en) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Use of fluorochemical compounds for diagnostic purposes using imaging techniques |
JP2011190183A (en) * | 2010-03-11 | 2011-09-29 | Noguchi Institute | Fluorous sugar-bonded crown ether derivative |
US9976072B2 (en) | 2014-03-26 | 2018-05-22 | Chevron U.S.A. Inc. | Multicarboxylate compositions and method of making the same |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
US11104639B2 (en) | 2016-09-14 | 2021-08-31 | Daikin Industries, Ltd. | Branched fluorine-containing compound |
KR102464647B1 (en) | 2016-11-28 | 2022-11-08 | 바이엘 파마 악티엔게젤샤프트 | High Relaxation Gadolinium Chelate Compounds for Use in Magnetic Resonance Imaging |
CN113164628A (en) | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | Contrast medium preparation and preparation method thereof |
CN109867635A (en) * | 2019-02-14 | 2019-06-11 | 华东师范大学 | A kind of T1 type micella magnetic resonance imaging contrast and preparation method thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19603033A1 (en) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoroalkyl-containing metal complexes, processes for their preparation and their use in NMR diagnostics |
JPH10112939A (en) * | 1996-10-07 | 1998-04-28 | Nec Corp | Power switching circuit |
DE19729013A1 (en) * | 1997-07-03 | 1999-02-04 | Schering Ag | Oligomeric, perfluoroalkyl-containing compounds, processes for their preparation and their use in NMR diagnostics |
US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
-
2000
- 2000-08-11 DE DE10066210A patent/DE10066210B4/en not_active Expired - Fee Related
-
2001
- 2001-07-23 YU YU10603A patent/YU10603A/en unknown
- 2001-07-23 NZ NZ523932A patent/NZ523932A/en unknown
- 2001-07-23 PL PL01365596A patent/PL365596A1/en not_active Application Discontinuation
- 2001-07-23 CA CA002419223A patent/CA2419223A1/en not_active Abandoned
- 2001-07-23 UA UA2003032067A patent/UA82642C2/en unknown
- 2001-07-23 RU RU2003105810/15A patent/RU2290206C2/en not_active IP Right Cessation
- 2001-07-23 AU AU7754901A patent/AU7754901A/en active Pending
- 2001-07-23 IL IL15438501A patent/IL154385A0/en unknown
- 2001-07-23 EE EEP200300061A patent/EE200300061A/en unknown
- 2001-07-23 EP EP01955366A patent/EP1307236A2/en not_active Withdrawn
- 2001-07-23 KR KR10-2003-7002023A patent/KR20030022387A/en not_active IP Right Cessation
- 2001-07-23 AU AU2001277549A patent/AU2001277549B2/en not_active Ceased
- 2001-07-23 BR BR0113188-5A patent/BR0113188A/en not_active IP Right Cessation
- 2001-07-23 HU HU0300736A patent/HUP0300736A3/en unknown
- 2001-07-23 MX MXPA03001287A patent/MXPA03001287A/en active IP Right Grant
- 2001-07-23 WO PCT/EP2001/008498 patent/WO2002013874A2/en not_active Application Discontinuation
- 2001-07-23 CZ CZ2003392A patent/CZ2003392A3/en unknown
- 2001-07-23 SK SK157-2003A patent/SK1572003A3/en not_active Application Discontinuation
- 2001-07-23 JP JP2002519012A patent/JP2004506025A/en active Pending
- 2001-07-23 CN CNA018172717A patent/CN1469757A/en active Pending
- 2001-08-10 AR ARP010103833A patent/AR034139A1/en unknown
- 2001-08-10 TW TW090119643A patent/TWI296931B/en active
-
2003
- 2003-02-07 NO NO20030604A patent/NO20030604L/en not_active Application Discontinuation
- 2003-02-07 BG BG107542A patent/BG107542A/en unknown
- 2003-03-10 ZA ZA200301949A patent/ZA200301949B/en unknown
- 2003-03-10 HR HR20030173A patent/HRP20030173A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1469757A (en) | 2004-01-21 |
TWI296931B (en) | 2008-05-21 |
HUP0300736A2 (en) | 2003-09-29 |
UA82642C2 (en) | 2008-05-12 |
MXPA03001287A (en) | 2003-10-06 |
AU7754901A (en) | 2002-02-25 |
BG107542A (en) | 2003-09-30 |
HUP0300736A3 (en) | 2010-01-28 |
KR20030022387A (en) | 2003-03-15 |
JP2004506025A (en) | 2004-02-26 |
EE200300061A (en) | 2004-12-15 |
EP1307236A2 (en) | 2003-05-07 |
RU2290206C2 (en) | 2006-12-27 |
CZ2003392A3 (en) | 2003-09-17 |
AU2001277549B2 (en) | 2007-02-08 |
ZA200301949B (en) | 2004-12-14 |
NZ523932A (en) | 2007-07-27 |
HRP20030173A2 (en) | 2005-04-30 |
IL154385A0 (en) | 2003-09-17 |
DE10066210B4 (en) | 2008-02-28 |
CA2419223A1 (en) | 2003-02-11 |
WO2002013874A8 (en) | 2002-06-13 |
SK1572003A3 (en) | 2003-10-07 |
PL365596A1 (en) | 2005-01-10 |
AR034139A1 (en) | 2004-02-04 |
YU10603A (en) | 2006-05-25 |
WO2002013874A2 (en) | 2002-02-21 |
NO20030604D0 (en) | 2003-02-07 |
NO20030604L (en) | 2003-04-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A , 9A E 10 ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |