BR0015367A - Aumento e reparo de defeitos nos tecidos moles relacionados com a idade - Google Patents
Aumento e reparo de defeitos nos tecidos moles relacionados com a idadeInfo
- Publication number
- BR0015367A BR0015367A BR0015367-2A BR0015367A BR0015367A BR 0015367 A BR0015367 A BR 0015367A BR 0015367 A BR0015367 A BR 0015367A BR 0015367 A BR0015367 A BR 0015367A
- Authority
- BR
- Brazil
- Prior art keywords
- skin
- cells
- individual
- defect
- tissue
- Prior art date
Links
- 230000007547 defect Effects 0.000 title abstract 5
- 210000004872 soft tissue Anatomy 0.000 title abstract 2
- 210000003491 skin Anatomy 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- 210000002744 extracellular matrix Anatomy 0.000 abstract 2
- 210000003041 ligament Anatomy 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000028169 periodontal disease Diseases 0.000 abstract 2
- 210000002435 tendon Anatomy 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 208000035484 Cellulite Diseases 0.000 abstract 1
- 206010019909 Hernia Diseases 0.000 abstract 1
- 208000034693 Laceration Diseases 0.000 abstract 1
- 206010049752 Peau d'orange Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 210000000577 adipose tissue Anatomy 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 230000036232 cellulite Effects 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 210000004748 cultured cell Anatomy 0.000 abstract 1
- 210000004207 dermis Anatomy 0.000 abstract 1
- 210000003195 fascia Anatomy 0.000 abstract 1
- 210000003754 fetus Anatomy 0.000 abstract 1
- 210000003780 hair follicle Anatomy 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 238000007665 sagging Methods 0.000 abstract 1
- 230000037390 scarring Effects 0.000 abstract 1
- 210000005070 sphincter Anatomy 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/066—Tenocytes; Tendons, Ligaments
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0661—Smooth muscle cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Rehabilitation Therapy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16373499P | 1999-11-05 | 1999-11-05 | |
| PCT/US2000/030623 WO2001032129A2 (en) | 1999-11-05 | 2000-11-06 | Augmentation and repair of age-related soft tissue defects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0015367A true BR0015367A (pt) | 2002-07-23 |
Family
ID=22591342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0015367-2A BR0015367A (pt) | 1999-11-05 | 2000-11-06 | Aumento e reparo de defeitos nos tecidos moles relacionados com a idade |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060039896A1 (https=) |
| EP (1) | EP1263931A4 (https=) |
| JP (1) | JP2003517858A (https=) |
| AU (1) | AU1472501A (https=) |
| BR (1) | BR0015367A (https=) |
| CA (1) | CA2390053A1 (https=) |
| WO (1) | WO2001032129A2 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660301B1 (en) * | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
| US7338657B2 (en) * | 2001-03-15 | 2008-03-04 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
| US6436424B1 (en) * | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| WO2001070289A2 (en) | 2000-03-20 | 2001-09-27 | Biosphere Medical, Inc. | Injectable and swellable microspheres for tissue bulking |
| MY130475A (en) | 2000-08-25 | 2007-06-29 | Contura As | Polyacrylamide hydrogel and its use as an endoprosthesis |
| WO2002092794A2 (en) * | 2001-05-17 | 2002-11-21 | Isotis N.V. | Isolation method of mesenchymal cells |
| US20050089512A1 (en) * | 2001-12-19 | 2005-04-28 | Kordula Schlotmann | Skin/hair equivalent with reconstructed papillae |
| US8394371B2 (en) | 2002-02-11 | 2013-03-12 | Neocutis Sa | Compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same |
| EP1587515A4 (en) * | 2002-08-23 | 2009-02-04 | Peter K Law | REPAIR AND BIOLOGICAL IMPROVEMENT OF THE SKIN |
| CA2958146C (en) | 2002-11-14 | 2019-08-20 | Aderans Research Institute, Inc. | Cultivation of hair inductive cells |
| US7326571B2 (en) | 2003-07-17 | 2008-02-05 | Boston Scientific Scimed, Inc. | Decellularized bone marrow extracellular matrix |
| US7905924B2 (en) * | 2003-09-03 | 2011-03-15 | Ralph Richard White | Extracapsular surgical procedure |
| AU2005215213C1 (en) | 2004-02-13 | 2011-04-28 | Smith & Nephew Orthopaedics Ag | Pharmaceutical composition comprising a fibrin matrix and dermal fibroblasts for the treatment of wounds |
| US20060134074A1 (en) * | 2004-08-30 | 2006-06-22 | Naughton Gail K | Compositions and methods for promoting hair growth |
| US20060058238A1 (en) | 2004-09-15 | 2006-03-16 | Lee Laurent-Applegate | Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same |
| GB0505202D0 (en) | 2005-03-14 | 2005-04-20 | Intercytex Ltd | Skin equivalent culture |
| EP1885280A1 (en) | 2005-05-26 | 2008-02-13 | Intercytex Limited | Tissue repair using allogenic dermal fibroblasts |
| US20070065415A1 (en) * | 2005-09-16 | 2007-03-22 | Kleinsek Donald A | Compositions and methods for the augmentation and repair of defects in tissue |
| WO2007035843A2 (en) * | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| JP5386180B2 (ja) | 2006-02-28 | 2014-01-15 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 真皮細胞のコンパクト凝集のための方法 |
| JP2009528856A (ja) * | 2006-03-03 | 2009-08-13 | オルガノジェネシス インク. | 口腔組織の再生および修復 |
| US20070224173A1 (en) * | 2006-03-21 | 2007-09-27 | Koullick Edouard A | Nonexpansion Protocol for Autologous Cell-Based Therapies |
| US8062673B2 (en) | 2006-04-11 | 2011-11-22 | E I Du Pont De Nemours And Company | Process for embolization using swellable and deformable microspheres |
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| US8252339B2 (en) * | 2006-04-11 | 2012-08-28 | Massachusetts Institute Of Technology | Medical treatment applications of swellable and deformable microspheres |
| US7794755B2 (en) * | 2006-04-11 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Process for preparation of swellable and deformable microspheres |
| US7914548B2 (en) * | 2006-04-17 | 2011-03-29 | Ustuner E Tuncay | Prevention or treatment of male pattern baldness method and device |
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| GB2440908A (en) * | 2006-05-25 | 2008-02-20 | Intercytex Ltd | Tissue Repair and Augmentation |
| EP2082030A2 (en) * | 2006-10-20 | 2009-07-29 | Keracure, Inc. | Devices with cells cultured on flexible supports |
| US20080208164A1 (en) * | 2007-02-28 | 2008-08-28 | Innovacell Biotechnologie Gmbh | Methods for the treatment of anal incontinence |
| US20220023503A9 (en) | 2007-05-10 | 2022-01-27 | Aziyo Med, Llc | Extracellular Matrix Tissue Prostheses |
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| US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
| US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
| US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
| WO2009144708A1 (en) * | 2008-04-14 | 2009-12-03 | Ganot, Arie | Augmentation and treatment of gingival defects |
| ES2654542T3 (es) * | 2008-04-30 | 2018-02-14 | Genomix Co., Ltd. | Procedimiento de recolección de células funcionales in vivo con alta eficiencia |
| AU2009201915C1 (en) | 2008-08-22 | 2015-02-26 | Regeneus Ltd | Therapeutic methods |
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| GB0820492D0 (en) | 2008-11-07 | 2008-12-17 | Sportcell | Cell compositions and uses thereof |
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| US8906045B2 (en) | 2009-08-17 | 2014-12-09 | Covidien Lp | Articulating patch deployment device and method of use |
| US11191786B2 (en) | 2009-10-28 | 2021-12-07 | StemRIM Inc. | Agents for promoting tissue regeneration by recruiting bone marrow mesenchymal stem cells and/or pluripotent stem cells into blood |
| EP3888714B8 (en) * | 2010-07-31 | 2025-05-21 | Cook Biotech Incorporated | Collagenous tissue pocket for an implantable medical device, and manufacturing method therefor |
| US9669200B2 (en) | 2010-08-06 | 2017-06-06 | Boston Scientific Scimed, Inc. | Systems and methods for the treatment of pelvic disorders including magnetic particulates |
| WO2012038923A1 (en) | 2010-09-22 | 2012-03-29 | Centre Hospitalier Universitaire Vaudois | Anti-fibrotic response provided by fetal cells to implants and delivery systems |
| US9180172B2 (en) | 2010-12-15 | 2015-11-10 | Ams Research Corporation | Treatment of Peyronies disease |
| US8979797B2 (en) | 2010-12-16 | 2015-03-17 | Ams Research Corporation | High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics |
| EP2703487B1 (en) | 2011-04-26 | 2018-06-27 | Genomix Co., Ltd. | Peptide for inducing regeneration of tissue and use thereof |
| CN104203146A (zh) * | 2012-02-01 | 2014-12-10 | 株式会社器官再生工学 | 牙科用种植体及其制造方法 |
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| US20150258148A1 (en) * | 2012-06-06 | 2015-09-17 | University Of Central Florida Research Foundation, Inc. | Compositions, Methods and Systems for Cellular Differentiation from Stem Cells |
| CN103083723B (zh) * | 2013-01-18 | 2015-02-11 | 暨南大学 | 胶原/纳米纤维素皮肤再生材料及其制备方法与应用 |
| US20150037434A1 (en) * | 2013-08-02 | 2015-02-05 | The Trustees Of Columbia University In The City Of New York | Biomaterials derived from tissue extracellular matrix |
| JP6260165B2 (ja) * | 2013-09-24 | 2018-01-17 | 株式会社ワコール | 着圧生成部を有する衣類 |
| US9861410B2 (en) | 2016-05-06 | 2018-01-09 | Medos International Sarl | Methods, devices, and systems for blood flow |
| US11969459B2 (en) | 2017-01-27 | 2024-04-30 | StemRIM Inc. | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
| WO2019107530A1 (ja) | 2017-12-01 | 2019-06-06 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
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-
2000
- 2000-11-06 CA CA002390053A patent/CA2390053A1/en not_active Abandoned
- 2000-11-06 EP EP00977033A patent/EP1263931A4/en not_active Ceased
- 2000-11-06 WO PCT/US2000/030623 patent/WO2001032129A2/en not_active Ceased
- 2000-11-06 AU AU14725/01A patent/AU1472501A/en not_active Abandoned
- 2000-11-06 JP JP2001534337A patent/JP2003517858A/ja active Pending
- 2000-11-06 BR BR0015367-2A patent/BR0015367A/pt not_active Application Discontinuation
-
2005
- 2005-07-06 US US11/175,981 patent/US20060039896A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2390053A1 (en) | 2001-05-10 |
| WO2001032129A3 (en) | 2001-10-04 |
| AU1472501A (en) | 2001-05-14 |
| EP1263931A2 (en) | 2002-12-11 |
| JP2003517858A (ja) | 2003-06-03 |
| WO2001032129A2 (en) | 2001-05-10 |
| EP1263931A4 (en) | 2009-07-15 |
| US20060039896A1 (en) | 2006-02-23 |
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