BR0014199A - Biphenyl derivatives as nhe-3 inhibitors - Google Patents

Biphenyl derivatives as nhe-3 inhibitors

Info

Publication number
BR0014199A
BR0014199A BR0014199-2A BR0014199A BR0014199A BR 0014199 A BR0014199 A BR 0014199A BR 0014199 A BR0014199 A BR 0014199A BR 0014199 A BR0014199 A BR 0014199A
Authority
BR
Brazil
Prior art keywords
nhe
inhibitors
biphenyl derivatives
biphenyl
derivatives
Prior art date
Application number
BR0014199-2A
Other languages
Portuguese (pt)
Inventor
Dieter Dorsch
Peter Raddatz
Norbert Beier
Claudia Wilm
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0014199A publication Critical patent/BR0014199A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE BIFENILA COMO INIBIDORES DE NHE-3". Compostos de fórmula I na qual X, R^ 1^, R^ 2^, R^ 3^, R^ 4^ e R^ 5^ têm os significados indicados na reivindicação de patente 1, são inibidores do trocador de sódio/próton do subtipo 3 (NHE-3).Invention Patent: "Biphenyl Derivatives as NHE-3 Inhibitors". Compounds of formula I in which X, R1, R3, R3, R3, R4 and R5 have the meanings indicated in patent claim 1, are sodium / proton exchanger inhibitors. of subtype 3 (NHE-3).

BR0014199-2A 1999-09-22 2000-09-04 Biphenyl derivatives as nhe-3 inhibitors BR0014199A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19945302A DE19945302A1 (en) 1999-09-22 1999-09-22 Biphenyl derivatives as NHE-3 inhibitors
PCT/EP2000/008616 WO2001021582A1 (en) 1999-09-22 2000-09-04 Biphenyl derivatives used as nhe-3 inhibitors

Publications (1)

Publication Number Publication Date
BR0014199A true BR0014199A (en) 2002-05-21

Family

ID=7922831

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014199-2A BR0014199A (en) 1999-09-22 2000-09-04 Biphenyl derivatives as nhe-3 inhibitors

Country Status (16)

Country Link
EP (1) EP1214291A1 (en)
JP (1) JP2004500338A (en)
KR (1) KR20020033818A (en)
CN (1) CN1555356A (en)
AU (1) AU7649700A (en)
BR (1) BR0014199A (en)
CA (1) CA2387529A1 (en)
CZ (1) CZ2002815A3 (en)
DE (1) DE19945302A1 (en)
HU (1) HUP0202891A3 (en)
MX (1) MXPA02003087A (en)
NO (1) NO20021407D0 (en)
PL (1) PL355097A1 (en)
SK (1) SK3342002A3 (en)
WO (1) WO2001021582A1 (en)
ZA (1) ZA200203095B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10163239A1 (en) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituted imidazolidines, process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
DE10304374A1 (en) 2003-02-04 2004-08-05 Aventis Pharma Deutschland Gmbh Novel substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
US20050054705A1 (en) 2003-02-04 2005-03-10 Aventis Pharma Deutschland Gmbh N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10341240A1 (en) 2003-09-08 2005-04-07 Aventis Pharma Deutschland Gmbh Substituted thienoimidazoles, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
DE102005001411A1 (en) 2005-01-12 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them
EP2170872B1 (en) 2007-06-28 2010-09-01 Sanofi-Aventis U.S. LLC Process for the preparation of the n-(2-chloro-4-methyl-3-thienyl)-1h- benzimidazol-2-amine hydrochloride and intermediates thereof
JP5745406B2 (en) 2008-09-02 2015-07-08 サノフイ Substituted aminoindanes and analogs thereof, and pharmaceutical uses thereof
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
ES2657938T3 (en) 2008-12-31 2018-03-07 Ardelyx, Inc. Compounds and methods to inhibit NHE-mediated anti-port in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
PL2695881T3 (en) 2011-03-15 2016-11-30 Guanidine compound
CN103012200B (en) * 2011-09-20 2014-12-17 北京大学 Compound with beta-secretase inhibition function, preparation method and applications thereof
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN104902930A (en) 2012-08-21 2015-09-09 阿德利克斯公司 Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
ES2735992T3 (en) 2013-04-12 2019-12-23 Ardelyx Inc NHE3 binding compounds and procedures to inhibit phosphate transport
LT3173408T (en) 2014-07-25 2018-12-27 Taisho Pharmaceutical Co., Ltd. Phenyl tetrahydroisoquinoline compound substituted with heteroaryl
EP3565808A1 (en) 2017-01-09 2019-11-13 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
EA201991676A1 (en) 2017-01-09 2020-01-30 Арделикс, Инк. NHE-MEDIATED ANTI-PORT INHIBITORS
BR112020002322A2 (en) 2017-08-04 2020-09-01 Ardelyx, Inc. glycyrrhetinic acid derivatives for the treatment of hyperkalaemia
AU2020218255A1 (en) 2019-02-07 2021-09-09 Ardelyx, Inc. Glycyrrhetinic acid derivatives for use in treating hyperkalemia
JP2022533251A (en) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド Combinations to lower serum phosphate in patients

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19548812A1 (en) * 1995-12-27 1997-07-03 Hoechst Ag Use of inhibitors of the cellular Na · + · / H · + · exchanger (NHE) for the manufacture of a medicament for respiratory stimulation
DE19622222A1 (en) * 1996-06-03 1997-12-04 Hoechst Ag Use of sodium=proton exchange inhibitor
DE19737224A1 (en) * 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmaceutical preparation for cardiovascular treatment
DE19819548A1 (en) * 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenyl derivatives

Also Published As

Publication number Publication date
NO20021407L (en) 2002-03-21
MXPA02003087A (en) 2003-08-20
CN1555356A (en) 2004-12-15
JP2004500338A (en) 2004-01-08
EP1214291A1 (en) 2002-06-19
ZA200203095B (en) 2003-09-23
WO2001021582A1 (en) 2001-03-29
KR20020033818A (en) 2002-05-07
HUP0202891A3 (en) 2003-11-28
CZ2002815A3 (en) 2002-08-14
NO20021407D0 (en) 2002-03-21
DE19945302A1 (en) 2001-03-29
SK3342002A3 (en) 2002-07-02
PL355097A1 (en) 2004-03-22
HUP0202891A2 (en) 2003-02-28
AU7649700A (en) 2001-04-24
CA2387529A1 (en) 2001-03-29

Similar Documents

Publication Publication Date Title
BR0014199A (en) Biphenyl derivatives as nhe-3 inhibitors
FR17C0003I2 (en) STEROIDS AS FXR AGONISTS
TR200102800T2 (en) New compounds.
BR0114045A (en) Polyarylcarboxamides useful as lipid lowering agents
ES2182234T3 (en) METALOPROTEASE INHIBITORS.
BR0010220A (en) Pyrimidinone compounds
BR0209149A (en) Phthalazinones
CY1106247T1 (en) THIOPHEN- AND THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS
BR9713338A (en) Benzonaphyridines as bronchial therapeutics.
DE60121461D1 (en) CONDENSED PYRIDOINDOL DERIVATIVES
DE60230127D1 (en) INHIBITORS OF INTEGRIN ALPHA-V-BETA-6
AR027734A1 (en) BISAMIDINE COMPOUNDS AS NHE-3 INHIBITORS
SE0103710D0 (en) Compounds
MXPA02012493A (en) 1-aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents.
TR200201128T2 (en) Tetrahydrothiopyraniphalazinone derivatives as PDE4 inhibitors.
AP2001002188A0 (en) 5HT1 antagonists for antidepressant therapy.
BR9813719A (en) Therapeutic agents
TR200401052T4 (en) New compounds
BR0002505A (en) 4-arylpiperidine derivatives for the treatment of pruritus
BR0115996A (en) Sulfamidothienopyrimidines
BRPI0415034A (en) aminopyridine derivatives as inducible non-synthase inhibitors
EA200301101A1 (en) DERIVATIVES OF PIPERAZINE AND THEIR APPLICATION AS PDE4 INHIBITORS
SE9904128D0 (en) Novel compounds
BR9913282A (en) Substituted 3-aryl-pyrazoles
PT1244614E (en) TRIPTASE INHIBITORS

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1927 DE 11/12/2007.