BR0010666A - Compositions and methods for extending life - Google Patents

Compositions and methods for extending life

Info

Publication number
BR0010666A
BR0010666A BR0010666-6A BR0010666A BR0010666A BR 0010666 A BR0010666 A BR 0010666A BR 0010666 A BR0010666 A BR 0010666A BR 0010666 A BR0010666 A BR 0010666A
Authority
BR
Brazil
Prior art keywords
inhibition
compositions
life
methods
results
Prior art date
Application number
BR0010666-6A
Other languages
Portuguese (pt)
Inventor
Alexey G Ryazanov
Kektarios Tavernarakis
Monica Driscoll
Karen Pavur
Bradley Nefsky
Original Assignee
Univ Medicine And Destistry Of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Medicine And Destistry Of filed Critical Univ Medicine And Destistry Of
Publication of BR0010666A publication Critical patent/BR0010666A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"COMPOSIçõES E MéTODOS PARA O PROLONGAMENTO DO TEMPO DE VIDA". A inibição específica da cinase de EF-2 resulta no prolongamento significante do tempo de vida sem quaisquer efeitos prejudiciais no comportamento, desenvolvimento e reprodução. Além disso, a inibição desta enzima diminui a taxa de envelhecimento e resulta em um aumento de mais de duas vezes no período sexualmente ativo do tempo de vida. A inibição da atividade da enzima resulta na mudança de proteína geral menor, o que é positivamente relacionado à diminuição na taxa de envelhecimento e aumento no tempo de vida."COMPOSITIONS AND METHODS FOR LONG LONG EXTENSION". Specific inhibition of EF-2 kinase results in significant prolongation of life without any detrimental effects on behavior, development and reproduction. In addition, inhibition of this enzyme decreases the rate of aging and results in a more than two-fold increase in the sexually active period of life. Inhibition of enzyme activity results in lower overall protein change, which is positively related to decreased aging rate and increased life span.

BR0010666-6A 1999-04-08 2000-04-08 Compositions and methods for extending life BR0010666A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12839799P 1999-04-08 1999-04-08
PCT/US2000/009209 WO2000061780A1 (en) 1999-04-08 2000-04-08 Compositions and methods for extending life span

Publications (1)

Publication Number Publication Date
BR0010666A true BR0010666A (en) 2003-07-22

Family

ID=22435184

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010666-6A BR0010666A (en) 1999-04-08 2000-04-08 Compositions and methods for extending life

Country Status (4)

Country Link
AU (1) AU4451900A (en)
BR (1) BR0010666A (en)
CA (1) CA2369996A1 (en)
WO (1) WO2000061780A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006002416A2 (en) * 2004-06-24 2006-01-05 University Of Medicine And Dentistry Of New Jersey Methods and means for increasing resistance to cell damage

Also Published As

Publication number Publication date
WO2000061780A9 (en) 2001-11-15
AU4451900A (en) 2000-11-14
WO2000061780A1 (en) 2000-10-19
CA2369996A1 (en) 2000-10-19

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired