BR0010666A - Compositions and methods for extending life - Google Patents
Compositions and methods for extending lifeInfo
- Publication number
- BR0010666A BR0010666A BR0010666-6A BR0010666A BR0010666A BR 0010666 A BR0010666 A BR 0010666A BR 0010666 A BR0010666 A BR 0010666A BR 0010666 A BR0010666 A BR 0010666A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibition
- compositions
- life
- methods
- results
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000032683 aging Effects 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 102000000564 Elongation Factor 2 Kinase Human genes 0.000 abstract 1
- 108010016831 Elongation Factor 2 Kinase Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000001627 detrimental effect Effects 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- 230000018791 negative regulation of catalytic activity Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSIçõES E MéTODOS PARA O PROLONGAMENTO DO TEMPO DE VIDA". A inibição específica da cinase de EF-2 resulta no prolongamento significante do tempo de vida sem quaisquer efeitos prejudiciais no comportamento, desenvolvimento e reprodução. Além disso, a inibição desta enzima diminui a taxa de envelhecimento e resulta em um aumento de mais de duas vezes no período sexualmente ativo do tempo de vida. A inibição da atividade da enzima resulta na mudança de proteína geral menor, o que é positivamente relacionado à diminuição na taxa de envelhecimento e aumento no tempo de vida."COMPOSITIONS AND METHODS FOR LONG LONG EXTENSION". Specific inhibition of EF-2 kinase results in significant prolongation of life without any detrimental effects on behavior, development and reproduction. In addition, inhibition of this enzyme decreases the rate of aging and results in a more than two-fold increase in the sexually active period of life. Inhibition of enzyme activity results in lower overall protein change, which is positively related to decreased aging rate and increased life span.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12839799P | 1999-04-08 | 1999-04-08 | |
PCT/US2000/009209 WO2000061780A1 (en) | 1999-04-08 | 2000-04-08 | Compositions and methods for extending life span |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0010666A true BR0010666A (en) | 2003-07-22 |
Family
ID=22435184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0010666-6A BR0010666A (en) | 1999-04-08 | 2000-04-08 | Compositions and methods for extending life |
Country Status (4)
Country | Link |
---|---|
AU (1) | AU4451900A (en) |
BR (1) | BR0010666A (en) |
CA (1) | CA2369996A1 (en) |
WO (1) | WO2000061780A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006002416A2 (en) * | 2004-06-24 | 2006-01-05 | University Of Medicine And Dentistry Of New Jersey | Methods and means for increasing resistance to cell damage |
-
2000
- 2000-04-08 BR BR0010666-6A patent/BR0010666A/en not_active Application Discontinuation
- 2000-04-08 CA CA002369996A patent/CA2369996A1/en not_active Abandoned
- 2000-04-08 WO PCT/US2000/009209 patent/WO2000061780A1/en not_active Application Discontinuation
- 2000-04-08 AU AU44519/00A patent/AU4451900A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000061780A9 (en) | 2001-11-15 |
WO2000061780A1 (en) | 2000-10-19 |
CA2369996A1 (en) | 2000-10-19 |
AU4451900A (en) | 2000-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |