BR0009916A - Derivados de tetraidroisoquinolinil-indol para o tratamento de depressão - Google Patents

Derivados de tetraidroisoquinolinil-indol para o tratamento de depressão

Info

Publication number
BR0009916A
BR0009916A BR0009916-3A BR0009916A BR0009916A BR 0009916 A BR0009916 A BR 0009916A BR 0009916 A BR0009916 A BR 0009916A BR 0009916 A BR0009916 A BR 0009916A
Authority
BR
Brazil
Prior art keywords
tetrahydroisoquinolinyl
depression
treatment
indole derivatives
alkoxy
Prior art date
Application number
BR0009916-3A
Other languages
English (en)
Inventor
Richard Eric Newshaw
Kristin Lynne Meagher
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR0009916A publication Critical patent/BR0009916A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE TETRAIDROISOQUINOLINIL-INDOL PARA O TRATAMENTO DE DEPRESSãO". São fornecidos compostos que têm fórmula (I), na qual: R~ 1~, R~ 2~, R~ 3~ e R~ 4~ são, independentemente, hidrogênio, halogênio, alcóxi ou carboxamida; R~ 5~ é hidrogênio, halogênio, CF~ 3~, CN; carbamida e alcóxi; e X é (CH~ 2~)~ n~ ou um anel carbocíclico de 4 a 6 membros, em que n é um número inteiro de 2 a 4; ou sais farmaceuticamente aceitáveis destes.
BR0009916-3A 1999-04-22 2000-04-20 Derivados de tetraidroisoquinolinil-indol para o tratamento de depressão BR0009916A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15520799P 1999-04-22 1999-04-22
US29804199A 1999-04-22 1999-04-22
PCT/US2000/010647 WO2000064886A1 (en) 1999-04-22 2000-04-20 Tetrahydroisoquinolinyl-indole derivatives for the treatment of depression

Publications (1)

Publication Number Publication Date
BR0009916A true BR0009916A (pt) 2002-01-15

Family

ID=26852102

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009916-3A BR0009916A (pt) 1999-04-22 2000-04-20 Derivados de tetraidroisoquinolinil-indol para o tratamento de depressão

Country Status (6)

Country Link
US (1) US6245780B1 (pt)
EP (1) EP1171434A1 (pt)
CN (1) CN1348450A (pt)
AU (1) AU4475300A (pt)
BR (1) BR0009916A (pt)
WO (1) WO2000064886A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8586298B2 (en) 2002-11-19 2013-11-19 Clluone Diagnostics A/S Methods and kits for diagnosing and treating b-cell chronic lymphocytic leukemia
CN101712675B (zh) * 2008-10-07 2013-07-03 江苏恒谊药业有限公司 苯并含氮杂环衍生物及其在治疗神经精神疾病药物的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314896A (en) * 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
WO1994024105A1 (en) * 1993-04-15 1994-10-27 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists

Also Published As

Publication number Publication date
AU4475300A (en) 2000-11-10
CN1348450A (zh) 2002-05-08
US6245780B1 (en) 2001-06-12
WO2000064886A1 (en) 2000-11-02
EP1171434A1 (en) 2002-01-16

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired
B25D Requested change of name of applicant approved