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Application filed by Neurogen CorporationfiledCriticalNeurogen Corporation
Priority to BG96205ApriorityCriticalpatent/BG60516B1/en
Publication of BG96205ApublicationCriticalpatent/BG96205A/en
Publication of BG60516B1publicationCriticalpatent/BG60516B1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Nitrogen Condensed Heterocyclic Rings
(AREA)
Abstract
Циклоалкиловите и азациклоалкиловите пиролпиримидини са силно селективни агонисти, антагонисти или инверсни агонисти на -аминобутировокисели мозъчни рецептори. Лекарствата, получени от тях, се използват при диагностика и лечение на лошо настроение, сънливост и на други подобни неразположения при предозиране с лекарства от вида на бензодиазепините и за повишаване на вниманието. Съединенията са с формула в която n има стойност 0, 1 или 2 и r1, r2, х, y и w имат различни значения. Изобретението се отнася и до техните фармацевтично приемливи нетоксични соли. 92 претенцииCycloalkyl and azacycloalkyl pyrrolepyrimidines are highly selective agonists, antagonists or inverse agonists of -aminobutyric acid brain receptors. Medicines derived from them are used in the diagnosis and treatment of moodiness, drowsiness and other similar ailments in overdose with drugs of the benzodiazepine type and to increase attention. The compounds are of the formula where n has the value 0, 1 or 2 and r1, r2, x, y and w have different meanings. The invention also relates to their pharmaceutically acceptable non-toxic salts. 92 claims
BG96205A1992-04-091992-04-09Cycloalkyl and azacycloalkyl pyrrolpyridimines
BG60516B1
(en)
DERIVATIVES OF 3-OXO-PIRIDO (1,2-A-) BENCIMIDAZOL-4-CARBOXYL AND 4-OXO-AZEPINO (1,2-A) BENCIMIDAZOL-5-CARBOXYL USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM.
Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethyonate for treatment and prophylaxis of dependence, tolerance and sensitization to medicinal agents, agent containing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, method of prophylaxis and treatment of dependence, compositions and agent containing 3,5-diamino-6-(2,3-dichlorophenyl-1,2,4-triazine)
NEW SYNTHETIC PEPTIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE ADMINISTRATION OF DRUGS THROUGH THE BLOOD-BRAIN BARRIER AND THE RETINA.