BG66048B1 - Composition and method for obtaining anti-dandruff cosmetic gel - Google Patents

Abstract

The invention relates to a cosmetic anti-dandruff gel containing ketoconazole and comprising the following components in mass %: ketoconazole - 0.01 to 3, polyacrylate or carboxyvinyl polymer - 0.01 to 2, rN regulator - 0.01 to 2, glycerin - 0.1 to 15, selenium disulphide - 0.01 to 2, fatty alcohol - 1 to 50, chamomile oil - 0.001 to 1, and water q. s. ad 100.0. The anti-dandruff gel is obtainedby initially obtaining gel containing thickener and a pH regulator, whereat ketoconazole is added to a dosed quantity of fatty alcohol with t = 40-45 degrees, the resulting solution is added by constant stirring to the initially obtained gel with rN = 6.8 do 7.2 containing polyacrylate or carboxyvinyl polymer, selenium disulfide dispersed in water is added to the resulting smooth mass and, after homogenization to obtain a smooth mass, chamomile oil and glycerin are added thereto. This is followed by homogenization up to obtaining the finished gel.

Description

The invention relates to a composition and method for the preparation of a ketoconazole-based cosmetic antitumor gel and its use in cosmetics.

BACKGROUND OF THE INVENTION

Ketoconazole-based dosage forms are known, in particular shampoos, which are applied to the scalp to prevent and treat dandruff.

RU 2 246 291 relates to ketoconazole-based shampoo for the treatment and prevention of lichens, seborrheic dermatitis and dandruff.

US 5,854,246 relates to an emulsion containing ketoconazole and other dermatologically acceptable carriers as the active ingredient.

GB 2665770 relates to a pharmaceutical composition suitable for topical administration containing a fungicidally active imidazole derivative in solution.

The main function of the shampoo is to wash, so the antidote is washed along with the foam of the shampoo and there is not enough time to affect the dandruff. Due to the nature of the form - shampoo and appropriate composition, the anti-dandruff is dispersed, not dissolved, which significantly reduces the effectiveness of their effect. The use of anti-dandruff shampoos does not always meet the other pure aesthetic requirements of the user for the hair: shine, volume, easy combing, etc. In some cases, even the anti-dandruff action is in complete contradiction with the user's wishes regarding the appearance and condition of the hair after using shampoo and other surface form (eg lotion).

The cosmetic anti-dandruff gel according to the invention has ketoconazole with chemical name as piperazine, 1-acetyl-4 (4- (2,4-dichlorophenyl) -2- (1H-imidazol-1-ylmethyl) - 1,2-dioxolan-4-yl) methoxy) phenyl) 1 cis, representing a synthetic imidazole dioxalane derivative.

Ketoconazole has antifungal activity against dermatophytes such as Trichophyton sp., Epidermophiton sp., Microsporum sp. and yeast-like fungi Candida sp., Pityrosporum ovale and Pityrosporum orbiculare.

The mechanism of action is to inhibit the synthesis of ergosterol in the lipid membranes required for the synthesis of mushroom cell walls. The permeability of the cell walls is impaired and the fungi lose their ability to form colonies.

SUMMARY OF THE INVENTION

It is an object of the invention to create a cosmetic anti-dandruff gel. The composition according to the invention consists of the following components (wt.%):

ketoconazole from 0.01 to 3% polyacrylic acid or its

alkali salt and carboxyvinyl- polymer from 0.01 to 2% pH regulator from 0.01 to 2% glycerin from 0.1 to 15% selenium disulfide from 0.01 to 2% fatty alcohol from 1 to 50% camomile oil from 0.001 to 1% water q. s. ad 100.0%.

In this composition, the fatty alcohol may be ethyl, isopropyl, isobutyl, propyl and butyl alcohol, or mixtures thereof.

The pH regulator may be monoethanolamine, triethanolamine, sodium hydroxide, potassium hydroxide, ammonium hydroxide, diisopropylamine, triethylamine or mixtures thereof.

The carboxyvinylpolymer can be selected from all types commercially available.

The cosmetic anti-dandruff gel is obtained by pre-production of a gel containing a thickener and a pH regulator, characterized in that ketoconazole is added to a metered amount of fatty alcohol at t = 40-45 ° C, the resulting solution is stirred continuously with pre-stirring the resulting gel with a pH = 6.8 to 7.2 containing polyacrylic acid or its alkali salt or carboxyvinylpolymer is dispersed in water to the resulting smooth mass

66048 B1 selenium disulfide, after homogenization to obtain a smooth mass, chamomile and glycerin oil is added thereto, followed by homogenization to obtain the finished gel.

The method is as follows.

Half of the recipe amount of demineralized water is dosed. With constant stirring, the required amount of thickener is added to the formulation. It gets wet and homogenises. Phase A is obtained.

About 1/6 of the recipe water is dosed separately. To this is added a weighted pH regulator. It is homogenized and slowly, with continuous stirring, it is applied to phase A. Stirring is continued until a smooth gel is obtained with a pH = 6.8-7.2. The dosage of the pH adjuster should be very slow even with continuous monitoring of the pH value. In case of overdose, the high pH cannot be lowered. This is phase B.

Following is a dosage of fatty alcohol which is heated to t = 40-45 ° C and ketoconazole is added thereto, stirring until complete dissolution. The resulting solution was slowly added portionwise with continuous stirring to phase B. Stirring was continued until a smooth mass was obtained. This is phase C.

The formulation of selenium disulfide is dispersed in the remaining formulation of water. The resulting suspension was applied to phase C. Homogenized to give a smooth homogeneous mass. Chamomile oil and a moisturizer are added to the mass thus obtained. Homogenized. The resulting gel was analyzed and submitted for packing.

The anti-superficial cosmetic gel allows fatty alcohol to be included in its composition. It is a solvent of ketoconazole, retaining its antifungal action, even at many times lower concentrations. This reduces the risk of adverse effects of ketoconazole on the human body. At the same time, oily alcohol and ketoconazole exert a highly synergistic anti-dandruff effect on the combination of the anti-dandruff ketoconazole and selenium disulfide in the composition according to the invention.

Due to the fact that the gel does not change the appearance of the hair after use, it can remain on the scalp between hair washes. This provides a long exposure time and guarantees a lasting anti-dandruff effect.

Cosmetic Dandruff Gel does not in any way restrict the user from using any other cosmetics and procedures related to the good appearance of the hair, including the use of preferred shampoos (non-dandruff).

Examples of carrying out the invention

Example 1

Preparation of anti-dandruff gel with composition:

Ultras 21 - 0.400 kg

Triethanolamine - 0.400 kg Ketoconazole - 0.200 kg Selenium disulfide - 0.200 kg Ethyl alcohol - 35.000 kg Glycerin - 1.000 kg Chamomile oil - 0.001 kg Demineralized water - q.s. ad 100,000 kg.

Half of the amount of demineralized water is dosed into the homogenizer and 0.400 kg of Ultrase 21 is applied to it with continuous stirring. It is wetted and homogenized.

About 1/6 of the formulation water is dosed in a separate vessel and 0.400 kg of triethanolamine is added to it. It is homogenized and slowly stirred to the above phase with continuous stirring and stirring is continued until a smooth gel is obtained. The pH is constantly monitored.

Ethanol 35,000 kg is dosed in a separate container, heated to t = 40-45 ° C, 0,200 kg of ketoconazole is added thereto and stirred until completely dissolved. The resulting solution was slowly applied portionwise with continuous stirring to the resulting smooth gel. Stirring is continued until smooth.

The remaining recipe amount of water is dosed in a separate container. It doses 0,200 kg of selenium disulfide and is dispersed with a colloidal mill.

The resulting slurry is then applied to the ready phase, which is a smooth mass. Homogenize to obtain a smooth homogeneous mass, to which 0.001 kg of mass is added.

66048 Blam of camomile and 1,000 kg of glycerin. Homogenization is followed to obtain the finished gel.

Application method

The cosmetic dandruff gel is applied with light massaging movements at the roots 5 of washed and dried hair. It does not wash and remains on the scalp until the next wash.

Claims (4)

1. Cosmetic anti-dandruff gel containing ketoconazole, characterized in that it consists of ketoconazole of 0.01 to 3 wt. % ;, polymer selected from polyacrylic acid or its alkali salt and carboxyvinylpolymer from 0.01 to 2 wt. %, pH regulator from 0.01 to 2 wt. %, glycerol from 0.1 to 15 wt. %, selenium disulfide 01 0.01 to 2 wt. %, fatty alcohol from 1 to 50 wt. %, camomile oil from 0.001 to 1% and water to 100%. Gel according to claim 1, characterized in that in the composition, the fatty alcohol is selected from the group consisting of ethyl, isopropyl, isobutyl, propyl and butyl alcohol. Gel according to any one of claims 1 and 2, characterized in that in the composition, the pH regulator is selected from the group of monoethanolamine, triethanolamine, sodium hydroxide, potassium hydroxide, ammonium hydroxide, diisopropylamine, triethylamine. Method for the preparation of a cosmetic antidermal gel according to claim 1 in the preparation of a gel containing a thickener and a pH regulator, characterized in that ketoconazole is added to the dosed amount of fatty alcohol at a temperature of 40-45 ° C, the resulting solution is continuous stirring of the pre-prepared gel with a pH of 6.8 to 7.2 containing polyacrylic acid or its alkali salt or carboxyvinyl polymer, the selenium disulfide dispersed in water after the homogenized until chamomile and glycerin are added to the smooth mass, homogenization is followed to form the finished gel.