BG65714B1 - Biologically active product - Google Patents

Abstract

The invention relates to biologically active product on medicinal herb basis, which shall find application in the production of food additives in the pharmaceutical industry, and in human and veterinary medicine. It comprises obtained without any heat treatment alcoholic extracts of fresh garlic, thyme (Thimus sp. div.), penny royal (Mentha piperita), savoury (Satureja montana), sweet basil (Ocimum basilicum), plantain (Plantago major) and common balm (Melissa officinalis) in ethanol from 20 to 98%.

Description

Technical field

The invention relates to a biologically active herbal product that will find application in the fields of food additives, pharmacy, human and veterinary medicine.

BACKGROUND OF THE INVENTION

Formulations used in Eastern medicine (Chinese, Korean, etc.) are known in which they are used alone or in combination with other vegetable raw materials garlic, mainly dried, powdered or in the form of oil or alcohol extracts. A number of products of the western pharmaceutical industry are known on the same basis, mainly for the purpose of immunostimulation and prophylaxis, but also for the treatment of certain diseases in humans.

The disadvantage of most of the known products containing garlic as a constituent is that it is usually processed, including thermally for the production of garlic essential oil, decoctions and oil extracts, as well as for drying and grinding it to a powdery state, making it curative qualities greatly decrease. The use of chemical additives and preservatives in most well-known products is also adversely affected.

It is known that biologically active phytochemicals for pharmaceutical preparations of essential oils, herbal decoctions and oil infusions are obtained by distillation and / or extraction of the respective plant parts with ethyl alcohol, propylene glycol and the like.

For example, BG 100802 is a prophylactic agent for use as a food and pharmaceutical product, which is a homogeneous mixture of dried and ground garlic bulbs, dried ginseng extract and a mixture of vitamins and trace elements, which strengthens the immune system, increases hemoglobin synthesis, lowers high blood pressure and sugar, regulates the function of the digestive tract and cardiovascular system.

JP 22433631 discloses a medicament for antitumor activity obtained by the extraction of APst Sativum.

BG 62757, analog of NL 1016519 according to PCT / NL1996 / 000210, discloses pharmaceutical compositions based on herbal essential oils for human and veterinary medicine with anti-inflammatory properties, including mainly wild oregano - Origanum vulgaris, Thymus serpilha thyme, Mint - piperita - Miterita , savory - Saturea hortensis and others.

SUMMARY OF THE INVENTION

It is an object of the present invention to provide a composition comprising, without heat treatment, alcoholic extracts of fresh garlic and other plants having medicinal properties that have a combined effect of simultaneous anti-radiation, immunostimulatory, anti-inflammatory, anti-viral, anti-bacterial and antimicrobial activity influence on the processes of metabolism, regulation of the functions of the digestive tract, the immune, cardiovascular and endocrine systems of the body.

The problem is solved by the proposed biologically active product, which includes a combination of obtained without heat treatment of extracts of fresh Allium Sativum (garlic), Thymus Serpyllum div (thyme), Saturea Montana (savory), Mentha piperita (Jojn), Ocimum basilicum (basil), Plantago major (deciduous plantain) and Melissa Officinalis (urea) in 20 to 98% ethyl alcohol.

The quantitative ratio of the components of the composition according to the invention in weight units of kg and 1 is from 0.15 to 0.95 kg of fresh Allium Sativum, from 0.01 to 0.25 kg of Thymus Serpyllum div, from 0.01 to 0.25 kg of Mentha piperita, from 0.01 to 0.25 kg of Saturea Montana, from 0.01 to 0.25 kg Ocimum basilicum, 0.01 to 0.25 kg Plantago major, 0.01 to 0.25 kg Melissa Officinalis and 11 to 20 to 98% ethyl alcohol.

As fresh Allium Sativum (garlic) can be used peeled and ground cloves of old garlic or ground whole stalks of young garlic.

The thyme, mint, savory, basil, deciduous and hub may be fresh or dried.

The ethanol used as the extractor

65714 B1 agent may be from 20 to 98%.

The product according to the invention is prepared as follows.

The plant components are ground into a blender or pressed mechanically. The resulting mass is poured into ethyl alcohol, sealed in glass, enamel or plastic containers and allowed to age for 2 to 30 days, then filtered. The resulting extract is bottled in plastic bottles with screw caps.

The biologically active product thus prepared is used as a powerful immunostimulant, as a prophylactic and therapeutic agent against viral, bacterial and fungal infections, for liquefying and assisting the secretion of lungs, nasopharynx, nasal cavity, prophylaxis and treatment of atherosclerosis, blood vessels, to reduce the level of bad cholesterol in the blood, to prevent and treat cancer, to counteract the side effects of lecherapy and chemotherapy, o nating pathogenic flora of the intestine without affecting normal one for the prevention and treatment of dysentery.

The advantages of the product according to the invention are the following:

- the prophylactic and curative qualities are achieved and maintained on the basis of the use of natural vegetable raw materials, without the participation of additional chemicals and stabilizers;

- the impact of the herbal products incorporated into it after machining is many times greater than the individual herbal decoctions and extracts;

- the individual components are in an optimal ratio, which allows to achieve a synergistic effect in the combined prophylactic and therapeutic effect;

- when used properly on an empty stomach with sufficient fluid, no unpleasant odor of garlic is emitted.

An exemplary embodiment of the invention

The foregoing examples illustrate the invention without limiting its scope.

Example 1.

150 g of peeled and ground garlic cloves of old garlic, 10 g of ground thyme stems, 10 g of ground beetroot, 10 g of savory thyme, 10 g of basil, 10 g of deciduous plantain; Pour 10 grams of ground beetroot into 1 30% ethyl alcohol. The resulting mixture was sealed in glass containers and allowed to mature for 2 to 30 days until a characteristic yellowish green color was obtained. The mixture was then filtered and the resulting extract was bottled.

Example 2.

In a manner similar to that described in Example 1, a product is prepared that contains 450 g of pressed fresh garlic cloves, 25 g of pressed thyme stems, 25 g of pressed juniper stems, 25 g of pressed savory stems, 25 g of basil presses, 25 g pressed shoots of broadleaf; 25 g of pressed husks covered with 1150% ethyl alcohol. The resulting mixture was sealed in glass containers and allowed to mature for 2 to 30 days until a characteristic yellowish green color was obtained. The mixture was then filtered and the resulting extract was bottled.

Example 3.

In a manner similar to that described in Example 1, a product is prepared which contains 950 g of pressed fresh garlic cloves, 50 g of dried thyme stems, 50 g of dried mint stems, 50 g of dried savory stems, 50 g of dried basil stalks, 50 g dried leaves of broadleaf; 50 g of dried husks covered with 1198% ethyl alcohol. The resulting mixture was sealed in glass containers and allowed to mature for 2 to 30 days until a characteristic yellow-green color was obtained. The mixture was then filtered and the resulting extract was bottled.

Data characterizing the final product of formulation # 2

The biologically active product of the invention obtained by formulation No. 2 can be characterized by the following qualitative and health-hygienic parameters and norms, as shown in Table 1.

65714 Bl

Table 1; , · Ί? '· _ _ Name ^ -. nvccmn el-ge * - f - ·. i,. . <· *. ·>'Μ _{r1 Jt} l_ _t Jp ίρΐ ¹ ' ⁴ i>. > ϊ- 4.7-¾¾ H V- ^t · 'G X1fak'1er11etics and norms ^- ₍ «*' 1 1. Appearance homogeneous liquid with small particles of raw materials used 2. Color yellowish green 3. The smell strongly expressed, characteristic of garlic 4. Ethyl alcohol content,% by weight,% to 50 5. Dry matter,% 8 ± 1.9 6. Energy value, kcal / 100 g 282 ± 25 7. Content of toxic elements, mg / kg, not more than: • Lead • Cadmium • Arsenic 0.1 0.01 0.1 RULES FOR SAMPLING AND TEST METHODS 5. Samples shall be taken in accordance with Regulation No 22/2003 of the M3 on the Conditions and Procedures for Sampling of Foods (SG No. 93/2003). 2. Organoleptic analysis shall be performed according to BDS 5757-80. 3. Determination of dry matter shall be carried out according to BDS ISO 939: 1998. 4. The determination of the ethyl alcohol content shall be carried out in accordance with BDS 6071-88. 5. Determination of arsenic is carried out by AAS with hydride generation according to BDS 17358-94, and lead and cadmium by AAS according to NCCMEX Hygiene Methods, Volume IV, 2002. Sampling preparation is performed according to BDS 17258 -91.

65714 Bl

Examples of application of the invention

In the preliminary clinical trials cited below, a final product was used with the composition and the preparation technology used for Formulation No. 2. Fewer experiments (not cited here) were conducted for Formulation No. 1 and Formulation No. 3, the results of which are close to those cited here in Table 2.

Table 2

:.:. --------- 1 -, ~ ⁴ - Named. 'Like- ⁴ > 4-Without - .. turnips' ephem 'Cm / yzr- C11CHC1! All effects' · ¹ /100% / 1. to overcome the complications of medical treatment in the thoracic region 10 people, the stomach area and the pelvic region 18 people 21 /75.0%/ without complications from radiation therapy 7 /25.0%/ no no 28 2. treatment of viral diseases / influenza / 34 / 94.4% / 2 / 5.6% / no no 36 3. Lowers blood pressure hypertension I, 6 people, hypertension, II, 4 people 6 / 60.0% / 4 / 40.0% / no no 10 4. Sinusitis 8 / 72.7% / 3 / 27.3% / no no 11 5. Bronchitis 14 / 87.5% / 2 / 12.5% / no no 16 Everything 83 / 82D% / 18 / 17.8% / no no 100/100% /

Detailed description of two clinical cases

1. In March and April 2003, "after $$ undergoing surgery for uterine stromal sarcoma, the patient underwent 28 pelvic radiation treatments. On the third day of radiation therapy, the patient experienced the first common complications - fatigue, pain, nausea, recurrent 4θ and diarrhea. A break of 3 days was made, during which the patient drank 2 tablespoons of the product on an empty stomach in the morning, lunch and evening. After 2 days, complications from radiation therapy disappeared. The patient drank the product three times a day throughout the course of medical treatment. By the end of the course of 28 medical treatments, the patient was feeling well; on the second week of radiation therapy, she stopped sick leave and went to work.

2. Patient with rectal cancer (colon cancer) - stage 4 after surgery in January 2002 in which the cancer has not been eliminated. In May 2003, the patient began to breathe hard, unable to move, stopped eating regularly due to lack of appetite, his skin had a brownish tinge. Due to advanced age (84 years) and stage 4 disease, no treatment was offered through medical, chemotherapy, or other treatment. An anesthetic program was offered to the family because of the projected recent adverse outcome of the disease (death). The patient began to drink the biologically active product (3 times a day with a tablespoon) and multivitamins from the beginning of June 2003 to the end of January 2004. In 1-2 weeks his patient

65714 Bl regained his appetite, started moving on his own, his skin regained its natural complexion, no pain. In December 2003, a scan was made to show that the patient had no internal metastases. As of March 10, 2004 the patient is alive, alive, without pain and moving independently, regardless of the medical prognosis for lethal outcome of the disease up to 1 month / ie. by the end of June. Since the beginning of February 2004, the patient has been drinking a maintenance dose of 1 teaspoon 3 times daily of the biologically active product.

Explanatory notes

Preliminary clinical results were obtained from the author with the assistance of patient volunteers from the Diagnostic and Consultative Center 29 - EOOD, Sofia and SCALO - EAD Sofia, with the consultative participation of Dr. Ani Varbancheva and Associate Professor Rumen Tsanev - Doctor of Medicine from the National Center in Hygiene, Medical Ecology and Nutrition - Sofia.

The trial period is from 31.12.2002 to 27.02.2004. Patients (Table 2) are aged up to 20 years - 21 people (20.8%), from 20 to 50 years - 58 people (57.4% ), over 50 years 22 people (21.8%).

The control period for reporting results for viral infections (influenza) is 5 days; for bronchitis - 20 days; for sinusitis 30 days; in hypertension from 1 to 3 months, depending on the degree of the disease; in radiation therapy - the duration of therapy.

The cure criteria are complete objective and subjective resolution of the symptomatology and no recurrence within the next 15 to 90 days (depending on the time of follow-up).

None of the biologically active products according to the invention have any negative side effects caused by the product. The use of the product should be consistent with the presence of alcohol, which may lead to adverse reactions in the presence of alcohol allergy or the use of alcohol drugs.

The biologically active product according to the invention is convenient for use because it is liquid and drinkable internally. The healing ingredients of the product reach the internal organs through the bloodstream, thus providing a complex prophylactic and healing effect. The drinking dose is determined by the patient's age, general clinical condition, body weight, type of disease, and stage of the disease.

Claims (6)

Claims 1. Biologically active product comprising alcoholic extracts of fresh Allium Sativum, Thymus Serpyllum div and Saturea Montana, characterized in that it also contains Mentha piperita, Ocimum basilicum, Plantago major and Melissa Officinalis with the following quantitative ratio of components in weight units kg and kg 1: 0.15 to 0.95 kg fresh Allium Sativum, 0.01 to 0.25 kg Thymus Serpyllum div, 0.01 to 0.25 kg Mentha piperita, 0.01 to 0.25 kg Saturea Montana, 0.01 to 0.25 kg Ocimum basilicum, 0.01 to 0.25 kg Plantago major, 0.01 to 0.25 kg of Melissa Officinalis and 11 to 20 to 98% ethyl alcohol. The biologically active product of claim 1, wherein the aged Allium Sativum peeled and ground cloves can be used as fresh Allium Sativum. The biologically active product according to claim 1, characterized in that peeled and pressed cloves of old Allium Sativum can be used as fresh Allium Sativum. The biologically active product of claim 1, characterized in that ground whole stalks of young Allium Sativum can be used as fresh Allium Sativum. 5. The biologically active product according to claim 1, characterized in that pressed stems of young Allium Sativum can be used as fresh Allium Sativum. The biologically active product according to claim 1, characterized in that the Thymus Serpyllum div, Saturea Montana, Mentha piperita, Ocimum basilicum, Plantago major and Melissa Officinalis can be fresh or dried shoots.