BG48730A1 - Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols - Google Patents
Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- olsInfo
- Publication number
- BG48730A1 BG48730A1 BG8918189A BG8918189A BG48730A1 BG 48730 A1 BG48730 A1 BG 48730A1 BG 8918189 A BG8918189 A BG 8918189A BG 8918189 A BG8918189 A BG 8918189A BG 48730 A1 BG48730 A1 BG 48730A1
- Authority
- BG
- Bulgaria
- Prior art keywords
- cyclohepta
- thiophen
- benzo
- methyl
- organo
- Prior art date
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Increased yield rates and high purity of the compounds with re-producible results can be achieved by this method. Substituted 4-1/1-methyl-4-piperidil/-4H-benzo /4,5/ cyclohepta /1,2-b/ thiophen-4-ols with the following formula:<IMAGE>in which A is H or OCH3, are prepared by reacting an organo-magnesium compound with 4H-benzo-/4,5/ cyclohepta /1,2-b/ thiophen-4-one with the following formula:<IMAGE>in which the values of H are as indicated. The organo-magnesium compound is obtained by adding drop-wise, while boiling, a mixture of 1-methyl-4-chloromethylpiperadine, 1,2-dibromethane and tetrahydrofuran to magnesium in tetrahydrofuran at molar ratios of 1 : 1.1 : 0.05 : 0.1 : 4. The obtained organo-magnesium halide reacts with 4H-benzo-/4,5/ cyclohepta /1,2-b/ thiophen-4-one at a molar ratio of 1 : 0.7, while isolating the final product out of the reaction mixture after hydrolysis is carried out directly by crystallization.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG8918189A BG48730A1 (en) | 1989-07-13 | 1989-07-13 | Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG8918189A BG48730A1 (en) | 1989-07-13 | 1989-07-13 | Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols |
Publications (1)
Publication Number | Publication Date |
---|---|
BG48730A1 true BG48730A1 (en) | 1991-05-15 |
Family
ID=3922106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG8918189A BG48730A1 (en) | 1989-07-13 | 1989-07-13 | Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols |
Country Status (1)
Country | Link |
---|---|
BG (1) | BG48730A1 (en) |
-
1989
- 1989-07-13 BG BG8918189A patent/BG48730A1/en unknown
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