BG48730A1 - Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols - Google Patents

Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols

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Publication number
BG48730A1
BG48730A1 BG8918189A BG8918189A BG48730A1 BG 48730 A1 BG48730 A1 BG 48730A1 BG 8918189 A BG8918189 A BG 8918189A BG 8918189 A BG8918189 A BG 8918189A BG 48730 A1 BG48730 A1 BG 48730A1
Authority
BG
Bulgaria
Prior art keywords
cyclohepta
thiophen
benzo
methyl
organo
Prior art date
Application number
BG8918189A
Inventor
Marin G Kazandzhiev
Georgi I Katsov
Nikolaj B Brankov
Aleksandar Kh Georgiev
Ivan A Again
Anka V Evstatieva
Zoja T Ivanova
Nikolina B Dimova
Kitsa G Slivkova
Original Assignee
Druzhestven N Izsledovatelski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Druzhestven N Izsledovatelski filed Critical Druzhestven N Izsledovatelski
Priority to BG8918189A priority Critical patent/BG48730A1/en
Publication of BG48730A1 publication Critical patent/BG48730A1/en

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Increased yield rates and high purity of the compounds with re-producible results can be achieved by this method. Substituted 4-1/1-methyl-4-piperidil/-4H-benzo /4,5/ cyclohepta /1,2-b/ thiophen-4-ols with the following formula:<IMAGE>in which A is H or OCH3, are prepared by reacting an organo-magnesium compound with 4H-benzo-/4,5/ cyclohepta /1,2-b/ thiophen-4-one with the following formula:<IMAGE>in which the values of H are as indicated. The organo-magnesium compound is obtained by adding drop-wise, while boiling, a mixture of 1-methyl-4-chloromethylpiperadine, 1,2-dibromethane and tetrahydrofuran to magnesium in tetrahydrofuran at molar ratios of 1 : 1.1 : 0.05 : 0.1 : 4. The obtained organo-magnesium halide reacts with 4H-benzo-/4,5/ cyclohepta /1,2-b/ thiophen-4-one at a molar ratio of 1 : 0.7, while isolating the final product out of the reaction mixture after hydrolysis is carried out directly by crystallization.
BG8918189A 1989-07-13 1989-07-13 Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols BG48730A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG8918189A BG48730A1 (en) 1989-07-13 1989-07-13 Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG8918189A BG48730A1 (en) 1989-07-13 1989-07-13 Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols

Publications (1)

Publication Number Publication Date
BG48730A1 true BG48730A1 (en) 1991-05-15

Family

ID=3922106

Family Applications (1)

Application Number Title Priority Date Filing Date
BG8918189A BG48730A1 (en) 1989-07-13 1989-07-13 Method for preparing of replaced 4- (1- methyl- 4- pyridile)- 4h- benzo |4, 5] cyclohepta |1, 2- b] thiophen- 4- ols

Country Status (1)

Country Link
BG (1) BG48730A1 (en)

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