BG36938A3 - Method for preparing sclareol - Google Patents

Method for preparing sclareol

Info

Publication number
BG36938A3
BG36938A3 BG055337A BG5533782A BG36938A3 BG 36938 A3 BG36938 A3 BG 36938A3 BG 055337 A BG055337 A BG 055337A BG 5533782 A BG5533782 A BG 5533782A BG 36938 A3 BG36938 A3 BG 36938A3
Authority
BG
Bulgaria
Prior art keywords
sclareol
alcohol
drug
extract
extracted
Prior art date
Application number
BG055337A
Other languages
Bulgarian (bg)
Inventor
Zsuzsanna Zoeld
Andras Gulyas
Peter Tetenyi
Istvan Zambo
Emil Minksovics
Eva Peter
Original Assignee
Gyogynoereny Kutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogynoereny Kutato Intezet filed Critical Gyogynoereny Kutato Intezet
Publication of BG36938A3 publication Critical patent/BG36938A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/78—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by condensation or crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)

Abstract

Метод за получаване на склареол и по-специално на екстракт с високо съдържание на склареол, в даден случай кристален склареол, характеризиращ се с това, че навлажнена, мокра или суха салвиева дрога, освободена от етерични масла, се екстрахира с 10-20-кратно количество спрямо дрогата смес от алкохол-вода, съдържаща 20-70% об.алифатен алкохол с 1-3 въглеродни атома при температура 2057'с, остатък, получен след отделяне на алкохола, в даден случай до 10-20%, се екстрахира с алифатен въглеводород с 5-8 въглеродни атома, в даден случай хлориран алифатен въглеводород, полученият органичен слой се концентрира и по желание така полученият екстракт се пречиства за отделяне на кристален склареол. Патентните претенции са формулирани в 10 точки.A method for obtaining sclareol and in particular an extract with a high content of sclareol, in a given case crystalline sclareol, characterized in that moistened, wet or dry salvia drug, freed from essential oils, is extracted with a 10-20-fold amount relative to the drug, an alcohol-water mixture containing 20-70% by volume of aliphatic alcohol with 1-3 carbon atoms at a temperature of 2057'C, a residue obtained after separation of the alcohol, in some cases up to 10-20%, is extracted with an aliphatic hydrocarbon of 5-8 carbon atoms, optionally a chlorinated aliphatic hydrocarbon, the resulting organic layer is concentrated and, if desired, the extract thus obtained is purified to separate crystalline sclareol. The patent claims are formulated in 10 points.

BG055337A 1981-02-11 1982-02-11 Method for preparing sclareol BG36938A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU81330A HU181595B (en) 1981-02-11 1981-02-11 Process for preparing sclareol or an extract containing sclareol

Publications (1)

Publication Number Publication Date
BG36938A3 true BG36938A3 (en) 1985-02-15

Family

ID=10949117

Family Applications (1)

Application Number Title Priority Date Filing Date
BG055337A BG36938A3 (en) 1981-02-11 1982-02-11 Method for preparing sclareol

Country Status (8)

Country Link
BG (1) BG36938A3 (en)
DE (1) DE3204595A1 (en)
ES (1) ES509521A0 (en)
FR (1) FR2499554B1 (en)
HU (1) HU181595B (en)
IT (1) IT1157922B (en)
PT (1) PT74411B (en)
SU (1) SU1297722A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741065B1 (en) * 1995-11-15 1997-12-26 Inst Francais Du Petrole PROCESS FOR THE PREPARATION OF SCLAREOL COMPRISING A STEP OF ADSORPTION CHROMATOGRAPHY ON SILICA

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1015461A (en) * 1948-08-23 1952-10-13 Knoll Ag Process to obtain a sage extract, rich in tannin
US3060172A (en) * 1959-04-29 1962-10-23 Reynolds Tobacco Co R Process for recovering sclareol from clary sage

Also Published As

Publication number Publication date
FR2499554A1 (en) 1982-08-13
IT8219589A0 (en) 1982-02-10
FR2499554B1 (en) 1985-12-06
PT74411B (en) 1983-07-08
DE3204595A1 (en) 1982-10-07
HU181595B (en) 1983-10-28
ES8301863A1 (en) 1983-01-16
IT1157922B (en) 1987-02-18
ES509521A0 (en) 1983-01-16
PT74411A (en) 1982-03-01
SU1297722A3 (en) 1987-03-15

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