BG1271U1 - Antimycotic preparation - Google Patents

Abstract

The utility model relates to an antimycotic preparation, in particular, to a preparation used against fungal and bacterial infections of the feet. It is based on the use of a combination of salicylicacid, ethyl alcohol, acetone, glycerine, caffeine, and sodium benzoate.

Description

Technical field

The utility model refers to an antifungal agent, in particular an agent for fungal and bacterial infections of the feet.

BACKGROUND OF THE INVENTION

A number of compositions are known to control odor, excessive sweating and fungus of the feet. Generally, they are based on the use of absorbents such as talc in combination with active flavoring ingredients, deodorants and antifungal agents in the form of organic solutions and are applied through aerosol spray systems. For example, US 682,656 includes a surfactant, a fragrance-rich oil, and an effective amount of a phenolic antifungal agent.

Although such forms provide an effective amount of the active ingredients, they have a number of disadvantages. First, the desiccant action of the absorbent and aerosol sprays lead to hardening and bruising of the skin of the feet, and organic solvents can cause irritation. Second, the solid compositions are not intended to clean the foot, but rather make deposits that further contaminate the feet, clothing and footwear. Finally, the aerosol delivery of the active substances carries the risk of the user being inhaled with volatile solvents such as metal chloride.

Formulations based on the properties of antibiotics as antifungal agents are also known. For example, according to JP 2004203895, a combination of amorolfin and terbinafine is used against pathogenic fungi of the species Trichophyton and Candida.

A disadvantage of antifungal agents of this type is the need for each of them to be tailored to the cause of the fungal infection, as well as to the specific features of the body of each patient.

BG 247 has an antimycotic agent that is based on the property of salicylic and benzoic acid to dissociate and denature protoplasmic proteins after passing through the shell of microorganisms. However, their effects on the skin as keratolytics are too drastic and can lead to systemic allergic reactions.

The object of the utility model is to provide a highly active antamycotic agent with a broad-spectrum effect against fungal and bacterial infections of the skin of the feet, which is suitable for use in secondarily infected dermatomycosis and at the same time serves as a refreshing lotion.

The technical nature of the utility model

The antifungal agent against fungal and bacterial infections of the feet, according to the utility model, is a composition comprising salicylic acid, ethyl alcohol, acetone, glycerol, caffeine and sodium benzoate in the following quantitative ratio (w / w): salicylic acid of 8.00 to 10,00; ethyl alcohol from 29.00 to 31.00; acetone from 29.00 to 31.00; glycerol from 29.00 to 31.00; caffeine from 0.08 to 0.16; sodium benzoate from 0.12 to 0.24.

The antifungal agent, according to the utility model, has antifungal, antiseptic, keratolytic and soothing effect and is therefore suitable for the treatment of epidermophytosis of the legs and inguinal folds, as well as for secondary infected dermatomycosis; at the same time it prevents the treated skin from drying and cracking, while maintaining its integrity and elasticity; it can be applied throughout the day as it is colorless, odorless, does not contaminate the skin, clothing and shoes and can also serve as a refreshing lotion.

Explanation of the attached figure

Figure 1 shows graphically the dynamics of the relative size of the mycelial surface in the presence of Trifluoperazine dihydrochloride (TFP), Nifedipine (NIF) and Caffeini sodium benzoate (COFF).

Examples of implementation of the utility model

The utility model is illustrated by the following examples, without limiting its scope.

Example 1.

In one embodiment, the antimycotic agent according to the utility model comprises 10.00 g of salicylic acid; 30.00 ml ethyl alcohol; 30.00 ml acetone; 30.00 ml glycerol, 0.08 g caffeine and 0.12 g sodium benzoate.

The method of preparing the composition provides for the preliminary dissolution of caffeine and sodium benzoate in 1 ml of distilled water, after which the resulting solution is mixed with the remaining components in a closed glass vessel. The mixture was stirred well and allowed to stand for 24 h at room temperature and the antimycotic agent thus obtained was ready for use. It is applied by rubbing on the affected areas with a cotton swab.

The benefits of an antifungal agent, according to the utility model, lie in its exceptional effectiveness; its inhibitory effect on disease organisms is due to both the combination of components in the composition and the presence of caffeine. The latter acts by disrupting the natural calcium homeostasis of the mushrooms [1], being a stabilizer of intracellular calcium deposits sensitive to Ryanodine [2], which in turn blocks growth.

Figure 1 shows the relative size of the mycelial area of the fungal pathogen Altemaria solani in the presence of Trifluoperazine dihydrochloride (TFP), Nifedipine (NIF) and Caffeini sodium benzoate (COFF). The mycelial area data are in relative units (compared to that without treatment) at η = 36 [3].

The figure shows that treatment with caffeine for more than 20 days permanently inhibits the growth of mycelium. In comparison, the other two pharmaceuticals - nifedipine and trifluoperazine, which also alter normal mushroom hyphae homeostasis by a mechanism other than caffeine, do not lead to the same effect: nifedipine blocks the entry of calcium ions through membrane-activated channels; trifluoperazine is a calmodulin antagonist [4, 5].

Claims (1)

Claims An antifungal agent, in particular an antifungal and bacterial foot infections based on salicylic acid, ethyl alcohol, acetone and glycerol, characterized in that it includes salicylic acid, ethyl alcohol, acetone, glycerin, caffeine and sodium benzoate in the following quantitative ratio by weight. hours: salicylic acid from 8.00 to 10.00; ethyl alcohol from 29.00 to 31.00; acetone from 29.00 to 31.00; glycerol from 29.00 to 31.00; caffeine from 0.08 to 0.16; sodium benzoate from 0.12 to 0.24.