BG106040A - Integrin receptor antagonists - Google Patents

Abstract

The invention relates to new compounds which bind to integrin receptors, as well as to their production, their use as integrin receptor antagonists and for the treatment of diseases, pharmaceutical preparations containing said compounds and pharmaceutical preparations containing at least one other active compound. 28 claims

Description

INTEGRINE RECEPTOR ANTAGONISTS

The invention relates to novel compounds that bind to integrin receptors, their preparation and administration.

Integrins are cell surface glycoprotein receptors that mediate interactions between cells of the same type and different cells, and between cells and extracellular matrix proteins. They are involved in physiological processes such as, for example, embryogenesis, haemostasis, wound healing, immune response, and the formation / maintenance of tissue structure.

Impaired expression of genes for cell adhesion molecules and impaired receptor function can contribute to the pathogenesis of a number of disorders, such as tumors, thromboembolism, cardiovascular disorders, pulmonary diseases, CNS diseases, kidney disease gastrointestinal tract or inflammation.

Integrins are heterodimers, each of which consists of one α and one transmembrane subunits, which are non-covalently linked. Currently, 16 different α and 8 different β subunits and 22 different combinations have been identified.

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Integrin α _ν β ₃ , also called vitronectin receptor, mediates adhesion to a large number of ligands - plasma proteins, extracellular matrix proteins, cell surface proteins - most of which contain the amino acid sequence RGD (Cell, 1986, 44, 1987, 517-518; , 238, 491-497) such as vitronectin, fibrinogen, fibronectin, von Willerbrand factor, thrombospondin, osteopontin, laminin, collagen, thrombin, tenascin, MMP-2, bone sialoprotein II, various viral, parasite and bacterial, bacterial and natural integrin antagonists such as disinfectant rhinos, neurotoxins-mambins, leech proteins, decorsin, ornatin, and some non-RGD ligands such as, for example, Cyr-61, RESAM (L Piali, J. Cell Biol. 1995, 130, 451460; Buckley, J. Cell Science 1996, 109, 437-445, J. Biol. Chem. 1998, 273, 3090-3096).

Several integrin receptors exhibit cross-reactivity with ligands that contain an RGD motif. Thus, the integrin _IIb RE, also called platelet fibrinogen receptor, recognizes fibronectin, vitronectin, thrombospondin, von Willerbrand factor and fibrinogen.

Integrin α _ν β ₃ is expressed inter alia in endothelial cells, blood platelets, monocytes / macrophages, smooth muscle cells, some B cells, fibroblasts, osteoclasts and various tumor cells such as, for example, melanomas, glioblastomas, lung carcinomas, breast , prostate and bladder, osteosarcomas and neuroblastomas.

Increased expression is observed in various pathological conditions, such as in the prothrombin condition, in cases of vascular disorders, tumor enlargement

01/283/02 / PB or metastases or reperfusion and on activated cells, in particular endothelial cells, smooth muscle cells or macrophages.

The involvement of integrin α _ν β ₃ has been established inter alia in the following pathological conditions:

cardiovascular disorders such as atherosclerosis, restenosis after vascular disorders, and angioplasty (neointima formation, smooth muscle cell migration, and proliferation) (J. Vase. Surg. 1994, 19, 125-134; Circulation 1994, 90, 2203-2206), acute renal impairment (Kidney Int. 1994, 46, 1050-1058; Proc. Natl. Acad. Sci. 1993, 90, 5700-5704; Kidney Int. 1995, 48, 13751385) associated with angiogenesis microangiopathies such as, for example, diabetic retinopathy or rheumatoid arthritis (Ann. Rev. Physiol 1987, 49, 453-464; Int. Ophthalmol. 1987, 11, 41-50; Cell 1994, 79, 1157-1164; J. Biol. Chem. 1992, 267, 10931 -10934), arterial thrombosis, stroke (Phase II studies with ReoPro, Centocor Inc., annual Europe an Stroke Meeting), cancer such as in tumor metastasis or tumor growth (tumor-induced angiogenesis) (Cell 1991, 64, 327-336; Nature 1989, 339, 58-61; Science 1995, 270, 1500-1502), osteoporosis (bone resorption after proliferation,

01/283/02 / PB Chemotaxis and Osteoclast Adhesion to the Bone Matrix (FASEB J. 1993, 7, 1475-1482; Exp. Cell Res. 1991, 195, 368-375, Cell 1991, 64, 327-336) , high blood pressure, psoriasis, hyperparathyroidism, paget's disease, malignant hypercalcemia, metastatic osteolytic lesions, inflammations, heart failure, CNF and for antiviral, antiparasitic or antibacterial therapy and prophylaxis (adhesion and internalization).

Because of their key role, pharmaceuticals containing low molecular weight integrin α _ν β ₃ have very good therapeutic and diagnostic application inter alia for the indicated indications.

Advantageous Ονβ ₃ integrin receptor antagonists bind to the integrin α _ν β ₃ receptor with increased affinity.

In particular, advantageous α _ν β ₃ integrin receptor antagonists further have increased selectivity for α _ν β ₃ integrin and have a lower effect on αβ3 with a factor of at least 10, preferably with a factor of at least 100 .

An integrin α _ν β ₃ antagonist effect and a beneficial in vivo effect are shown for a large number of compounds such as antiα _ν β ₃ monoclonal antibodies, peptides containing the RGD binding sequence, native RGD-containing proteins (eg disintegrins) and low molecular weight compounds

01/283/02 / PB weight (FEBS Letts 1991, 291, 50-54; J. Biol. Chem. 1990, 265, 1226712271; J. Biol. Chem. 1994, 269, 20233-20238; J. Cell Biol 1993 , 51, 206-218; J. Biol. Chem. 1987, 262, 17703-17711; Bioorg. Med. Chem. 1998, 6, 1185-1208).

WO 9708145 describes derivatives of meta-guanidino, urea, thiourea or azacyclic aminobenzoic acid and their application as α _ν β ₃ integrin receptor antagonists.

It is an object of the present invention to provide novel integrin receptor antagonists with advantageous properties.

We have found that this object is achieved by compounds of general formula I

A-E-G-L where A, E, G and L have the following meanings:

L is a structural element of formula l _L

R ³

II where a is 0 or 1,

T is a COOH group or radical that can be hydrolyzed to COOH,

R ² hydrogen, NHSO ₂ R ²¹ , NHCOR ^{21 or} NHCOOR ²² ,

01/283/02 / PB where

R ²¹ is a branched or unbranched, optionally substituted CrCe-alkyl, C ₃ -C _b cycloalkyl, C _d C ₄ -alkilS ₃ -C ₆ -cycloalkyl radical, a C ₅ -C ₁₂ -bitsikloalkilov or C ₆ -C ₁₈ -tritsikloalkilov a radical, one to three-substituted, with identical or different radicals, aryl, alkylaryl, hetarylalkyl radical or a 3- to 6-membered, saturated, unsaturated aromatic heterocycle which may contain up to three different or identical heteroatoms O, N, S, being possibly for two radicals to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain to three different or identical heteroatoms Ο, N, S, and this nucleus may be optionally substituted, or another, optionally substituted, saturated, unsaturated or aromatic nucleus may be fused to that nucleus.

R ²² is a branched or unbranched, optionally substituted C ₁ -C ₆ alkyl radical or an optionally substituted or optionally substituted aryl or alkylaryl radical,

R ³ is hydrogen - (CH ₂ ) _b - (X) _c -R ³¹

where b is 0, 1,2 or 3, c is 0 or 1,

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X is -S0 ₂ -, -S-, -Ο-, -CO-, -NH-SOr, -O-CO-, -CO-O-, -NHCO-, -CO-NH-, -CO-N (R ³¹ ) -, -N (R ³¹ ) -CO-, -SO2-NH-, SO2-N (R ³¹ ) - or-N (R ³¹ ) -SO2-,

R ³¹ is hydrogen, hydroxyl, branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, -O-alkylaryl or -O-aryl radical, one amino radical with a primary or optional secondary or tertiary substitution, one optional C C ₁ -C ₆ -alkyl or aryl-substituted C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -alkenyl radical, C ₅ -C ₁₂ bicycloalkyl, C ₆ -C ₁₈ -tricycloalkyl radical, or

A 3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain three different or identical heteroatoms Ο, N, S, C ₃ -C ₈ cycloalkyl, aryl or hetaryl radical , possibly for two radicals together to be fused, saturated, unsaturated or aromatic carbocycles or heterocycles or heterocycles which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted, or otherwise, optionally substituted, saturated, unsaturated, or or ap primate core can be fused to this core, and

R ⁴ is hydrogen, or branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, C ₃ -C 6 -alkenyl, C ₃ -C ₆ -alkynyl, or C ₃ -C ₆ -cycloalkyl radical,

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G is a structural element of formula l _G

where d is 0.1 or 2,

R ^{5 is} hydrogen, hydroxyl, branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C ₂ -C ₄ -alkoxy, -O-alkylaryl or -O-aryl radical, one amino radical with a primary or optional secondary or tertiary substitution, one optionally C 1 -C -alkyl- or aryl-substituted C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -alkenyl radical, C ₅ -C ₁₂ bicycloalkyl, C ₆ -C ₁₈ -tricycloalkyl radical, or

3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms Ο, N, S, C ₃ -C ₈ cycloalkyl, aryl or heterocycle radical , the two radicals being together may be a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted, or otherwise optionally substituted, saturated, an unsaturated or aromatic nucleus may be fused to that

01/283/02 / PB nucleus or side chain of a natural amino acid,

R ⁶ is hydrogen or branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ -alkynyl or C ₃ -C ₆ -cycloalkyl radical,

Is a structural element of Formula 1 _E

- (NH) _g - (CH ₂ ) _r Q- (CH ₂ ) _e -CO- I _E where is 0,1 or 2, f is 0 or 1, g is 0 or 1,

Q is a double bonded, optionally substituted hetaryl radical, possibly for two substituents together to be a saturated, unsaturated or aromatic carbocycle or heterocycle that may contain up to three different or identical heteroatoms Ο, N, S, and this nucleus may optionally be substituted, or otherwise, optionally substituted, saturated, unsaturated or aromatic nucleus may be fused to that nucleus,

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A one of the structural elements of the formula I _A ¹ to l _A ²⁰

JL · ⁵ ι R x. , n ο Ια ⁶ N 1 R ¹¹

R1 ,.

ar "

I 15

where

R ¹⁰ , R ¹¹ are, independently of one another, hydrogen, - (CH 2) _h - (Y) r R ¹⁰¹ , or both radicals together are a 3-membered 8-membered, optionally substituted, saturated, unsaturated or aromatic N-heterocycle, which may further comprise two other identical or different heteroatoms Ο, N or S,

01/283/02 / PB where h is 0,1,2 or 3, i is 0 or 1,

Y is -SO ₂ -, -S-, -Ο-, -CO-, -NH-SO2-, -O-CO-, -CO-O-, -NHCO-, -CO-NH-, -CO- N (R ¹⁰¹ ) -, -N (R ¹⁰¹ ) -CO-, -SO2-NH-, N (R ¹⁰¹ ) -SO2- or -SO ₂ -N (R ¹⁰¹ ) - and

R ¹⁰¹ is a hydroxyl group, substituted or unsubstituted, optionally substituted C ₁ -C ₆ -alkyl, C ₂ -C ₄ -alkoxy, -O-alkylaryl or -O-aryl radical, an amino radical with a primary or optional secondary or tertiary substitution, one optionally C ₂ -C ₄ -alkyl- or aryl-substituted C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -alkenyl, C ₅ -C ₂ -bicycloalkyl, C ₆ -C ₈ tricycloalkyl radical or 3- to 6-membered , a saturated or unsaturated heterocycle which is substituted by one to three identical or different radicals and which may contain up to three different or identical het eroatoms Ο, N, S, C ₃ . _8- cycloalkyl, aryl or hetaryl radical, possibly for two radicals to be fused, saturated, unsaturated or aromatic carbocycle or heterocycle, which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted , or another optionally substituted, saturated, unsaturated kernel may be fused to that kernel,

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R ¹² is a branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, alkylaryl, C ₃ -C ₆ -cycloalkyl or C ₁ -C ₄ alkyl-C ₃ -C ₆ -cycloalkyl radical, or an optionally substituted aryl radical,

R ¹³ is hydrogen, -OH, -CN, -CONH ₂ , branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, C ₂ -C ₄ -alkoxy or OCO-C ₂ -C ₄ -alkyl radical, or optionally substituted alkylaryl, -O -alkylaryl, -OCO-aryl, -OCOalkylaryl, or -OCO-allyl radical,

R ¹⁴ is hydrogen, branched or unbranched, optionally substituted _Cl-C4 alkyl, aryl, -CO ₂ C _d C ₄ -alkyl, -CO ₂ alkylaryl, -CO _{2-allyl, -CO-Cl-C 4} - alkyl, -CO-alkylaryl or -CO-allyl radical,

R ¹⁵ is hydrogen, branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl radical, or an optionally substituted aryl or alkylaryl radical.

R ¹⁶ , R ¹⁷ are independently, -NH ₂ , halogen or branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl or C ₂ -C ₄ -alkoxy radical or optionally substituted aryl radical,

Z ¹ , Z ² , Z ³ , Z ⁴ are independently CH, C-CH ₃ , C-OCH ₃ , Cl or N and physiologically tolerant salts, drug precursors and their enantiomerically pure or

01/283/02 / PB diastereomeric pure and tautomeric forms.

T in the structural element means a COOH group or radical that can be hydrolyzed to COOH. A radical that can be hydrolyzed to COOH means a radical that is converted to a COOH group after hydrolysis.

A group that can be noted as an example of radical T that can be hydrolyzed to COOH is o

¹¹ 1

-CR ¹ where R ¹ has the following meaning:

a) OM, where M may be a metal cation such as an alkali metal cation e.g. lithium, sodium, potassium, the equivalent of an alkaline earth metal cation such as e.g. calcium, magnesium and barium, or a competitive organic ammonium ion such as tertiary C ₂ -C ₄ -alkyl ammonium or ammonium ion, such as ONa, OK or OLi,

b) branched or unbranched, optionally halogen-substituted

C ₁ -C ₈ -alkoxy radical such as, for example, methoxy, ethoxy, propoxy, 1-methyl ethoxy, butoxy, 1-methylpropoxy, 2methylpropoxy, 1,1-dimethylethoxy, in particular methoxy, ethoxy, 1-methylethoxy, pentoxy, hexoxy, heptoxy, octoxy, difluoromethoxy, trifluoromethoxy, chlorodifluoromethoxy,

1-fluoroethoxy, 2-fluorotoxy, 2,2-difluoroethoxy, 1,1,2,2trifluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-1,1,2trifluoroethoxy or pentafluoroethoxy

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c) branched or unbranched, optionally halogen substituted, C ₁ -C ₄ -alkylthio radical such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2methylpropylthio or 1,1-dimethylethylthio radical

d) an optionally substituted -O-alkylaryl radical such as -O-benzyl

e) R ^{1 is} also a radical of the formula - (O) _m -N (R ¹⁸ ) (R ¹⁹ ), where m is 0 or 1, and R ¹⁸ and R ¹⁹ , which may be identical or different, have the following meaning :

hydrogen,

C ₁ -C ₈ -alkyl, such as methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2- dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3dimethylbutyl, 1,1-d and methyl butyl, 2,2-dimethylbutyl , 3,3 dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1 ethylbutyl, 2-ethylbutyl, heptyl or octyl,

With ₃ -C ₆ -alkenyl such as 2-propenyl, 2-butenyl, 3-butenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl,

3-pentenyl, 4-pentenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl,

3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1- ethyl-2-propenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl,

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3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl,

4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1, 1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl- 3-butenyl, 2,3-dimethyl-2-butenyl, 2,3dimethyl-3-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-

2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl and 1-ethyl-2-methyl-2-propenyl, especially 2-propenyl , 2-butenyl, 3-methyl-2-butenyl and 3methyl-2-pentenyl,

C ₃ -C ₆ -alkynyl such as 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 2-pentynyl, 3-pentynyl, 4pentinyl, 1-methyl-3-butynyl, 2-methyl- 3-butynyl, 1-methyl-2-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2pentynyl, 1- methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4pentinyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4pentinyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3- butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl, for n odpochitane 2-propynyl,

2-butynyl, 1-methyl-2-propynyl and 1-methyl-2-butynyl, especially 2-propynyl,

C ₃ -C ₈ -cycloalkyl, such as, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl, cyclooctyl, it being possible for these alkyl, cycloalkyl, alkenyl and alkynyl groups each to be substituted,

01/283/02 / DB phenyl optionally substituted one or more times, for example one to three putt, by halogen, nitro, cyano, Ci-Sdal alkyl, _Cl-C4 haloalkyl, _Cl-C4 alkoxy, C _d C ₄ -haloalkoxy or C ₁ -C 6 -alkylthio, such as 2-fluorophenyl, 3-chlorophenyl, 4-bromophenyl, 2-methylphenyl, 3-nitrophenyl, 4cyanophenyl, 2-trifluoromethylphenyl, 3-methoxyphenyl, 4-trifluoxythiophenyl, 4-trifluoromethyl dichlorophenyl, 2-methoxy-3-methylphenyl, 2,4-dimethoxyphenyl, 2-nitro-5-cyanophenyl, 2,6-difluorophenyl or R ¹⁸ and R ¹⁹ together form a C ₄ -C ₇ -alkylene chain which is ring-closed, is independent alzhitelno substituted, eg by C _d C ₄ alkyl and may contain a heteroatom selected from oxygen, sulfur or nitrogen, such as - (CH _{2) 4} -, - (CH _{2) 5} -, - (CH ₂ ) ₆ -, - (CH ₂ ) ₇ -, - (CH ₂ ) ₂ -O- (CH ₂ ) ₂ -, -CH ₂ -S- (CH ₂ ) ₃ -, (CH ₂ ) ₂ -O- ( CH ₂ ) ₃ -, -NH- (CH ₂ ) ₃ -, -CH ₂ -NH- (CH ₂ ) ₂ -, -CH ₂ -CH = CHCH ₂ -, -CH = CH- (CH ₂ ) ₃ - , -CO- (CH ₂ ) ₂ -CO- or -CO- (CH ₂ ) ₃ -CO-.

Preferred T radicals are -COOH, -CO-O-C ₂ -C ₈ -alkyl or CO-O-benzyl.

Branched or unbranched C 1 -C ₆ -alkyl radical for R ²¹ in the structural element L means, for example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1dimetilpropil, pentyl, 1-methylbutyl, 2- methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethyl butyl, 1,1-dimethylbutyl, 2,2dimethylbutyl, 3,3-dimethyl butyl, 1,1,2-trimethylpropyl, 1,2,2 trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl or 1-ethyl-2methylpropyl, preferably methyl, ethyl, propyl, butyl or i01 / 283/02 / PB butyl.

A branched or unbranched C ₃ -C ₆ -cycloalkyl radical for R ²¹ in the structural element L means, for example, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

A branched or unbranched C ₁ -C ₄ -alkyl-C ₃ -C ₆ -cycloalkyl radical for R ²¹ in the structural element L means the above C ₃ -C ₆ -cycloalkyl radical, which is a substituent on the C ₂ -C ₄ -alkyl radical.

C ₁ -C ₆ -alkyl radicals, C ₃ -C ₆ -cycloalkyl radicals or C ₂ -C ₄ -alkyl-C ₃ -C ₆ -cycloalkyl radical may be substituted by up to 5 identical or different radicals selected from the group of halogen, aryl or hetaryl.

C ₅ -C ₁₂ bicycloalkyl radical for R ²¹ means, for example, indanyl, norbornyl or camphil, and C ₆ -C ₁₈ -tricycloalkyl radical means, for example, adamantyl.

One to three substituted, identical or different radicals, aryl, alkylaryl, alkylhetharyl radical or a 3- to 6-membered, saturated, unsaturated or aromatic heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, optionally two radicals to be fused, saturated, unsaturated or aromatic carbocycles or heterocycles containing up to three different or identical heteroatoms Ο, N, S, and optionally substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring to be fused to this anger ro for R ²¹ in structural element L means, for example,

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Aryl radical, such as phenyl, 1-naphthyl or 2-naphthyl,

Alkaryl radicals such as benzyl or phenethyl,

Alkyltharyl radicals such as -CH ₂ -2-pyridyl, CH ₂ -3-pyridyl, -CH ₂ -4-pyridyl, -CH ₂ -2-trienyl, -CH ₂ -3-thienyl, CH ₂ -2-thiazolyl , -CH ₂ -4-thiazolyl, CH ₂ -5-thiazolyl, -CH ₂ -CH ₂ -2-pyridyl, -CH ₂ -CH ₂ -3-pyridyl, -CH ₂ -CH ₂ -4-pyridyl, -CH ₂ -CH ₂ -2thienyl, -CH ₂ -CH ₂ -3-thienyl, -CH ₂ -CH ₂ -2-thiazolyl, -CH ₂ -CH ₂ -4thiazolyl, or -CH ₂ -CH ₂ -5-thiazolyl, for preferably -CH ₂ -2-pyridyl, -CH ₂ -2-thienyl, or -CH ₂ -2-thiazolyl, or

Hetaryl radicals such as 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2 -oxazolyl, 4oxazolyl, 5-oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 3-isothiazolyl,

4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl or 6-pyridazinyl, preferably 2-pyridyl, 3-pyridyl, 3-pyridyl, 3-pyridyl, 3-pyridyl, 3-pyridyl, 3-pyridyl furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5thiazolyl, optionally substituted by aryl radicals, alkylaryl radicals, alkylhetharyl radicals and hetaryl radicals, with up to three identical or different radicals, for example or different radicals, for example from the following group:

-NO ₂ -NH ₂ . -OH, -CN, -COOH, -COO-C ₂ -C ₄ -alkyl, halogen, branched or unbranched, optionally substituted C 1 -C 4 -alkyl,

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C ₃ -C ₆ -cycloalkyl, C ₂ -C ₄ -alkoxy, C 1 -C 4 -alkylthio, -O-CH ₂ -COO-C ₁ -C ₄ -alkyl, -IN-CO-C ₁ -C ₆ -alkyl, -CO-IN- C 1 -C 4 alkyl, -NH-SO ₂ -C ₄ C ₄ alkyl, -8 O ₂ -NH-C ₂ -C ₄ -alkyl, -N (C ₁ -C ₄ -alkyl) ₂ , -NH-C ₁ -C ₄ -alkyl, or 8O ₂ - C ₁ -C ₄ -alkyl radical optionally substituted -NH-COphenyl, -CO-NH-phenyl, -NH-8O ₂ -phenyl, -8O ₂ -NH-phenyl, -NH-CObenzyl, -CO-NH-benzyl, -NH-SO ₂ -6eH3nn, -SO ₂ -NH-benzyl, an optionally substituted radical -SO ₂ -NT ¹ T ² or -CO-NT ¹ T ² where both the radicals T ¹ and T ² may form a cyclo amine, or

3- to 6-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, or two radicals together are fused, saturated, unsaturated or aromatic carbocycles or heterocycles which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted or another, optionally substituted nucleus may be fused to that nucleus.

Preferred substituents on aryl radicals, alkylaryl radicals, alkylhetharyl radicals, and hetaryl radicals for R ²¹ are C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkyl, COOH, -COOMe, -CF ₃ , -CN, C _g C ₄ -alkoxy, -SCH ₃ , -O-CH ₂ -COOH, phenyl, -SO ₂ CH ₃ , -NO ₂ , -OH, -NH ₂ , -N-pyrrolidinyl, -N-piperidinyl, -N-morpholinyl, - N-piperazinyl, -NH-C 1 -C 4 alkyl, -N (C 1 -C ₄ -alkyl) ₂ , F, Cl, Br or I.

Preferred substituents on aryl radicals, alkylaryl radicals, alkylhetharyl radicals are icetaryl radicals for R ²¹ in which the two radicals together are a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms, N, the kernel may optionally

01/283/02 / PB be replaced or another optional substituted nucleus may be fused to that nucleus, the following are double-linked structural elements:

A branched or unbranched C ₁ -C ₆ -alkyl radical for R ²² in the structural element L means, for example, the C ₁ -C 6 -alkyl radicals noted above for R ²¹ , preferably 1,1 dimethylethyl.

Examples of aryl radicals for R ²² in the structural element L are phenyl, 1-naphthyl or 2-naphthyl, preferably phenyl; alkylaryl radicals for R ²² in the structural element L are preferably benzyl or phenethyl.

Suitable substituents on the C ₂ -C 6 -alkyl radical, aryl radicals or alkylaryl radicals for R ²² in the structural element L are the substituents mentioned above for aryl radicals, alkylaryl radicals, alkylaryl radicals and heteroaryl radicals of R ²¹ .

In the radical R ³ in the structural element L, the index b may be 0, 1, 2 or 3, preferably 0, 1 or 2, and the index c may be 0 or 1. The radical X is a double bonded radical selected from the group of -SO2-, -S-, -0-, -CO-, -NH-SO2-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-, -CO- N (R ³¹ ) -, -N (R ³¹ ) -CO-, -SO2-NH-, -SO ₂ -N (R ³¹ ) - or 01/283/02 / PB

N (R ³¹ ) -SO ₂ -. In the case of radicals which are independently substituted by R ³¹ , the two R ³¹ radicals may be identical or different.

A branched or unbranched C ₁ -C ₆ -alkyl radical for R ³¹ in the structural element L means, for example, methyl, ethyl, propyl, 1methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl,

pentyl, 1-methylbutyl, 2-methyl butyl, 1,2-dimethylpropyl, 1,1- dimethylpropyl, 2,2-dimethyl propyl, 1-ethyl propyl, hexyl, 1- methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3- dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3- dimethylbutyl, 1,1,2-trimethyl propyl, 1,2,2-trimethylpropyl, 1-

ethyl butyl, 2-ethylbutyl or 1-ethyl-2-methylpropyl, preferably methyl, ethyl, propyl, butyl, isopropyl, sec-butyl and tert-butyl.

A branched or unbranched C ₁ -C ₄ -alkoxy radical for R ³¹ in the structural element L means, for example, methoxy, ethoxy, propoxy, 1-methyl ethoxy, butoxy, 1-methylpropoxy, 2methylpropoxy or 1,1-dimethylethoxy, in particular methoxy, ethoxy or 1-methyl ethoxy.

Examples of -O-alkylaryl or -O-aryl radicals are -Ophenyl, -O-1-naphthyl, -O-2-naphthyl or -O-benzyl.

The C ₁ -C ₆ -alkyl, C ₁ -C ₄ -alkoxy radicals of R ³¹ in the structural element L may be substituted by up to five identical or different radicals selected from the group of halogen, aryl or hetaryl.

Substituted -O-alkylaryl or -O-aryl radicals means, for example, the aforementioned -O-alkylaryl or -O-aryl radicals, optionally substituted by up to three identical or different radicals selected from

01/283/02 / PB the following group:

-N0 _2i -NH ₂ , -OH, -CN, -COOH, -COO-C ₁ -C ₆ -alkyl, halogen, whether branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkyl, C ₂ C _4- alkoxy, C ₂ -C ₄ -alkylthio, -O-CH 2 -COO-C 2 C ₄ -alkyl, -NH-CO-C 1 -C 4 alkyl, -CO-MH-C ₂ -C ₄ -alkyl, -NH-SO ₂ -C _r C ₄ alkyl, -SOrNH-Ci ^ alkyl, -N (C _d C ₄ -alkyl) _2, -NH-C _d C ₄ -alkyl, or 80 ₂ C _d C ₄ -alkyl radical, an optionally substituted -NHCO-phenyl, -CO-NH-phenyl, -NH-8O ₂ -phenyl, -SOrNH-phenyl, -NHCO-benzyl, -CO-NH-benzyl, -NH-SO ₂ -6eH3nn, -SOrNH-benzyl , an optionally substituted radical -SO ₂ -NT ¹ T ² or -CO-NT ¹ T ² where the two radicals T ¹ and T ² may form a cyclo amine, or

3- to 6-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, or two radicals together are fused, saturated, unsaturated or aromatic carbocycles or heterocycles , which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted or another, optionally substituted nucleus may be fused to that nucleus.

An amino radical with a primary or optional secondary or tertiary substitution for R ³¹ in the structural element L means a primary amino radical -NH ₂ , a secondary amino radical -NH (R ³¹¹ ) or a tertiary amino radical -N (R ³¹¹ ) (R ³¹² ), where

R ³¹¹ and R ³¹² may, independently of one another, be C ₂ -C ₄ -alkyl or C ₃ -C ₆ -cycloalkyl, as noted above, optionally substituted aryl, preferably phenyl, alkylaryl, preferably benzyl, -CO-C ₂ -C ₄ -alkyl, preferably -CO-CH ₃ or -CO-aryl, preferably -CO-phenyl.

asMM

01/283/02 / PB 23

In the case where c = 1 and X = CO, the corresponding amide residues are obtained.

Cyclic tertiary amide residues or amino radicals are obtained in the case where R ³¹ is one of the heterocyclic systems described below that are linked via nuclear nitrogen to X = CO or directly. Examples of preferred amide residues -XR ³¹ are:

0 A ^ N 0 \ _7 With _2- C6-alkynyl or With ₂ -C ₆ -alkenyl radical, which is optionally substituted C ₁ -C ₄ -alkyl or aryl for R ³¹ c

the structural element L means, for example, a C ₂ -C ₆ -alkynyl radical such as ethynyl, 2-propynyl, 2-butynyl, 3-butynyl,

1- methyl-2-propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-butynyl, 2-methyl-3-butynyl, 1-methyl-2-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4pentinyl, 2-methyl-3- pentynyl, 2-methyl-4-pentynyl, 3-methyl-4pentinyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl3-butynyl, 1,2-dimethyl-3- butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl or 1-ethyl-1-methyl-2-propynyl, preferably 2-propynyl or ethynyl or C1-C6-alkenyl radicals such as e.g. p, vinyl, 2-propenyl, 2-butenyl, 3-butenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-2-butenyl,

2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-

01/283/02 / PB

3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-propenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5- hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4methyl-3-pentenyl, 1-methyl- 4-pentenyl, 2-methyl-4-pentenyl, 3methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl- 2-butenyl, 1,2-dimethyl-3-butenyl,

1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 1- ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl,

1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl or 1-ethyl-methyl-2-propenyl, in particular 2-propenyl or vinyl which may be optionally substituted C ₁ -C ₄ -alkyl radicals or alkyl radicals as noted above, preferably phenyl, such as phenylethynyl or phenylethenyl, preferably.

C ₅ -C 1 ₂ -bitsikloalkilov radical for R ³¹ means, for example, indanyl, norbornyl or camphene, and C _{is a} C ₁₈ -tritsikloalkilov denotes, for example, adamantyl.

3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms Ο, N, S, C ₃ C ₈ -cycloalkyl, aryl or heterocycle radical , two radicals may be fused, saturated, unsaturated or aromatic carbocycles or heterocycles, which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted, or otherwise, optionally substituted, saturated, unsaturated or the aromatic ring to be fused to Com a

01/283/02 / PB core, for R ³¹ in structural element L means, for example

3- to 6-membered, saturated or unsaturated or unsaturated heterocycles which may contain up to three different or identical heteroatoms Ο, N, S, such as N-pyrrolidinyl, N-piperidinyl, N-hexahydroazepinyl, N-morpholinyl or N-piperazinyl, optionally three amino protons in heterocycles with free protons, such as N-piperazinyl, to be replaced by conventional amino protecting groups such as methyl, benzyl, Boc (tert-butoxycarbonyl), Z (benzyloxycarbonyl), tosyl, -8O ₂ -C _{d is 4-} alkyl, -8O ₂ -phenyl or -8O ₂ -benzyl,

C ₃ -C ₈ -cycloalkyl radicals as described above for R ²¹ , aryl radicals such as, for example, phenyl, 1-naphthyl or 2naphthyl, or hetaryl radicals such as 2-pyridyl, 3-pyridyl, 4-pyridyl, 2 -furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-oxazolyl, 4oxazolyl, 5-oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 4-pyrimidyl , 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 3-pyridazinyl, 6-pyridazinyl, 6-pyridazinyl, -pyridazinyl, preferably 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5-thiazolyl, optionally heterocyclic C ₃ -C ₈ -cycloalkyl, aryl and optionally substituted hetaryl radicals with up to three

01/283/02 / PB identical or different radicals, for example selected from the following group:

-NO ₂ , -NH ₂ -OH, -CN, -COOH, -COO-C ₁ -C ₆ -alkyl, halogen, branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, C ₃ -C ₆ -cycloalkyl, C ₁ -C ₆ -alkoxy, C ₂ -C ₄ -alkylthio, -O-CH ₂ -COO-C ₂ -C ₄ -alkyl, -NH-CO-C 1 -C 4 alkyl, -CO-IN-C ₁ -C ₄ -alkyl, -NH-SO 4 -C 1 - C 1-6 -Cyl-C ₁ -C ₄ -alkyl, -H (C ₁ -C ₄ -alkyl) ₂ , -NH-C ₂ -C ₄ -alkyl, or -C ₁ -C ₁ -C ₄ -alkyl optionally substituted -NH-COphenyl, -CO- NH-phenyl, -MH-8O ₂ -phenyl, -SOrNH-phenyl, -NH-CObenzyl, -CO-NH-benzyl, -NH-SO ₂ -6eH3nn, -SOrNH-benzyl, an optionally substituted radical -SO ₂ - NT ¹ T ² or -CO-NT ¹ T ² where the two radicals T ¹ and T ² can form a cyclo amine, or 3- to 6-h flax, optionally substituted, saturated, unsaturated or aromatic carbocycle or heterocycle, which may contain up to three different or identical heteroatoms Ο, N, S, or two radicals fused together, saturated, unsaturated or aromatic carbocycles or heterocycles which may contain up to three different or identical heteroatoms Ο, N, S, the nucleus may be optionally substituted, or another, optionally substituted nucleus may be fused to this nucleus.

Preferred substituents for heterocyclic, C ₃ -C ₈ cycloalkyl, aryl and hetaryl radicals for R ³¹ are C 1 -C 4 aryl, -COOH, -COOMe, -CF ₃ , -CN, C ₂ -C ₄ -alkoxy, -SCH ₃ , -O -CH ₂ COOH, -phenyl, -SO ₂ CH ₃ , -NO ₂ , -OH, -NH ₂ , -Ν-pyrrolidinyl-, -Npiperidinyl, -N-morpholinyl, -N-piperazinyl, -MH-C _g C _4- alkyl, M (C ₁ -C ₄ -alkyl) ₂ , F, Cl, Br or I.

Preferred substituents on heterocyclic, C ₃ -C ₈ cycloalkyl, aryl and hetaryl radicals for R ³¹ in which two

01/283/02 / PB radicals are fused together, are a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted or attached to this nucleus another, optionally substituted, kernel can be merged are the following, double-linked structural elements:

Examples of condensed nuclear systems for R ³¹ are, for example, the corresponding dioxolanyl, benzopyrrolyl, benzofuryl, benzothienyl or fluorenyl.

Branched or unbranched, optionally substituted C _D C ₄ alkyl radical for R ⁴ in the structural element L means, for example, methyl, ethyl, propyl, i-propyl, butyl, t-butyl or i-butyl, preferably methyl.

Branched or unbranched, optionally substituted, optionally substituted C ₃ -C ₆ -cycloalkyl radical for R ⁴ in the structural element L means the radicals mentioned above for R ²¹ , which are optionally substituted by up to 5 radicals such as halogen or aryl, preferably cyclohexyl, cyclopentyl or cyclopropyl.

C ₃ -C ₆ -alkenyl or C ₃ -C ₆ -alkynyl radicals for R ⁴ in

01/283/02 / PB structural element L are the radicals mentioned above for R ¹⁸ or 1Q

R, preferably aryl or propargyl.

Particularly preferred radicals for R ⁴ are hydrogen, methyl, cyclopropyl, allyl or propargyl, and hydrogen is particularly preferred.

Preferred structural elements L have a = 1, so that βamino acid represents the preferred basic structure of the structural element L. In particularly preferred structural elements L, both the radical R ² = hydrogen and the radical R ³ can vary widely as described by - above, or the radical R ³ = hydrogen and the radical R ² may vary as described above. Particularly preferred structural elements L have R ² = H and R ³ may vary widely as described above, or R ³ = H and R ² = -ΝΗΖ, -NH-802-phenyl or -NH-SO ₂ -6eH3nn where Z is a benzyloxycarbonyl protecting group.

In the structural element G of formula I _{G 1} R ⁵ denotes hydrogen and, independently of R ³¹ in the structural element L, the same radicals as described above for R ³¹ or another side chain of a natural amino acid. Preferred R ⁵ radicals are hydrogen, methyl, ethynyl or methyl-substituted ethynyl, with hydrogen being particularly preferred.

R ⁶ means, independently of R ⁴ , the same radicals as described above for R ⁴ . Preferred R ⁶ radicals are hydrogen, methyl, allyl, propargyl or cyclopropyl, with hydrogen being particularly preferred.

In the structural element E of the formula l _E , Q stands for double

01/283/02 / PB linked hetaryl radical which is optionally substituted with up to three other radicals, possibly where, where appropriate, two radicals may be together saturated, unsaturated or aromatic carbocycle or heterocycle containing up to three solutions or identical heteroatoms Ο, N, S, and the nucleus optionally may be optionally substituted, or another optionally substituted, saturated or aromatic nucleus may be fused to that nucleus.

Hetaryl radical preferably means a 5- or 6-membered aromatic heterocyclic system that may contain up to three different or identical heteroatoms Ο, N, S, possibly for the three amino protons in heterocycles with free amino protons, such as imidazolyl. triazolyl, pyrazolyl or pyrrolyl, to be substituted by conventional amino protecting groups such as, for example, methyl, benzyl, Boc (tert-butoxycarbonyl), Z (benzyloxycarbonyl), tosyl, -SO 2 -C 3 -C 6 -alkyl, -B 2 -phenyl or BO 2 -phenyl or BO 2 -phenyl or BO 2 -phenyl -benzyl.

Preferred hetaryl radicals Q that can be enumerated are the following structures, where the points of attachment are indicated by a solid line:

Ν '

N N

Particularly preferred hetaryl radicals Q, which can be enumerated, are the following structures, where the fixed positions of the connecting points are indicated by a solid line and the structures can be included in both orientations:

01/283/02 / PB

Particularly preferred hetaryl radicals Q, which can be enumerated, are the following structures, where the fixed positions of the junction points are indicated by a solid line and the structures can be included in both orientations:

As indicated above, the three amino protons of imidazolyl, pyrazolyl, triazolyl or pyrrolyl in these preferred and particularly preferred structures may also be substituted by conventional amino protecting groups such as, for example, methyl,

01/283/02 / BB benzyl, Boc (tert-butoxycarbonyl), Z (benzyloxycarbonyl), tosyl, -COG-C 1 -C 4 -alkyl, -Bog-phenyl or -Bog-benzyl.

Preferred substituents for the Hetaryl radicals are, independently of one another, one or two radicals selected from the group -CN, halogen, preferably Cl or F, C ₁ -C ₄ -alkyl, preferably methyl, C ₂ -C ₄ -haloalkyl, for preferably trifluoromethyl, C ₂ -C ₄ -alkoxy, preferably methoxy, -NH-C 1 -C ₄ -alkyl or aryl, preferably phenyl.

The structural element A is one of the structural elements of the formula 1 _A ¹ to 1 _A ²⁰

where the structural elements of the formula l _A ¹ , lA ² . k ³ > k ⁴ . to ⁵ . A ⁸ , 1A ¹⁰ , 1A ¹³ are preferred, and the structural element of the formula

01/283/02 / PB is particularly preferred for structural element A.

The radicals R ¹⁰ and R ¹¹ are, independently of one another and independently of R ³ , the radicals described above for R ³ in the structural element L, preferably C ₂ -C ₄ -alkyl, C ₃ -C ₈ -cycloalkyl, C _d C ₄ -alkyl-C ₃ -C ₈ cycloalkyl, aryl, alkylaryl, hetaryl or alkylhetharyl, with the possibility of the aryl, alkylaryl, hetaryl and alkylhetharyl radicals bearing up to three identical or different radicals of the group F, Cl, Br or I , C ₂ -C ₄ -alkyl, C ₃ -C ₆ cycloalkyl, -COOH, -COOMe, -CF ₃ , -CN, C ₂ -C ₄ -alkoxy, -SCH ₃ , -OCH ₂ -COOH, phenyl, -SO ₂ CH _3, -NO _2, -OH, -NH _2, -N-pyrrolidinyl, -Npiperidinil, -N-morpholine ynyl, -N-piperazinyl, -NH-StSd-alkyl-ADML-alkyl ^, -NH-CO-Cf--C-alkyl, -CO-NH-Cf--C -alkyl, -NH-SO ₂ Cf--C -alkyl, -SOrNH-C1-C6-alkyl, or -5O ₂ -C ₂ C ₄ -alkyl, optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SO ₂ phenyl, -8Ο ₂ -Ο -φβΗππ, -NH-CO-benzyl, -CO-NH-benzyl, -NH-SO ₂ benzyl, -SO ₂ -NH-6eH3nn, optionally substituted -SO ₂ -NT ¹ T ² or CO-NT ¹ T ² , where the two radicals T ¹ and T ² can form a cyclo amine,

Or the two radicals R ¹⁰ and R ¹¹ together are a 3- to 8-membered, optionally substituted, saturated, unsaturated or aromatic Neterocyclic system which may further comprise two other identical or different heteroatoms Ο, N, or S, such as pyrrolidinyl, piperidinyl, hexahydroazepinyl, piperazinyl or morpholinyl.

R ¹² is a branched or unbranched, optionally substituted C ₁ -C ₆ alkyl, alkylaryl, C ₃ -C ₆ -cycloalkyl or C ₂ -C ₄ -alkyl-C ₃ -C ₆ cycloalkyl radical or optionally substituted aryl radical, as described above for R ²¹ .

01/283/02 / PB

A branched or unbranched, optionally substituted C ₁ -C ₄ alkoxy or -O-alkylaryl radical for R ¹³ means the corresponding radicals as described above for R ³¹ , preferably methoxy or benzyloxy. The -OCO-C ₁ -C ₄ alkyl-, -OCO-aryl-, -OCO-alkylaryl- or -OCO-allyl radicals are covered by the group -OCO- and C ₂ -C ₄ -alkyl, aryl or alkylaryl radicals described by - above for R ³¹ or allyl radical.

Preferred R ¹³ radicals are hydrogen, -OH, -O-benzyl, -OCO-phenyl, -OCO-benzyl, -OCO-allyl, -CN or -CO-NH ₂ .

Similarly, the -CO ₂ -C 1 -alkyl-, -CO ₂ -alkylaryl-, CO ₂ -alkyl-, -CO-C 1 -C 6 -alkyl, -CO-alkylaryl- or -CO-allyl radicals of the radical R ¹⁴ are composed of the group -CO ₂ - or -CO- and C ₁ -C ₄ -alkyl, the aryl radicals described above for R ³¹ or the allyl radical. Preferred radicals for R ¹⁴ are hydrogen, methyl, benzyl, -COObenzyl, -COO-allyl, -CO-benzyl or -CO-allyl.

R ¹⁵ is hydrogen, branched or unbranched, optionally substituted C ₁ -C ₄ alkyl or optionally substituted aryl or alkylaryl radical as described above for R ²¹ or R ⁴ . Preferred R ¹⁵ radicals are hydrogen, methyl, benzyl or phenyl.

R ¹⁶ , R ¹⁷ are, independently of each other, -NH 2, halogen, such as Cl, Br, I or F or branched or unbranched, optionally substituted C 1 -C 4 -alkyl or C 1 -C 4 -alkoxy or optionally substituted aryl radical, as described below above for R ³¹ , preferably NH 2, Cl, F, methyl, methoxy or phenyl.

01/283/02 / PB

Ζ ¹ , Ζ ² , Ζ ³ , Ζ ⁴ are, independently of one another, CH, C-CH ₃ , C-OCH ₃ . CCI or Ν, preferably Ζ ¹ and Ζ ² or Ζ ² and Ζ ³ or Ζ ³ and Ζ ⁴ not being simultaneously Ν.

Unless specified in detail, substituted aryl, alkylaryl, hetaryl or alkylhetharyl radicals in the description mean aryl, alkylaryl, hetaryl or alkylhetharyl radicals which may be substituted by up to three identical or different radicals selected from the following group:

-ΝΟ ₂ , -NHz, -OH, -CN, -COOH, -O-CH ₂ -COOH, -COO-C ₁ -C ₆ -alkyl, halogen, branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, C ₃ -C _6- Cycloalkyl, C ₂ -C ₄ -alkoxy, C ₁ -C ₄ -alkylthio, -O-CH ₂ COO-C ₂ -C ₄ -alkyl, -NH-CO-C 1 -C 4 alkyl, -CO-MH-C ₂ -C ₄ -alkyl , -NH8O ₂ -C _g C ₄ -alkyl, -8O ₂ -NH-C _d C ₄ -alkyl, -N (C _d C ₄ -alkyl) _2, -NH-CrC ^ alkyl, or -8O ₂ -C _d C ₄ -alkyl radical, optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -MH-8O ₂ -phenyl, -SO ₂ -NH-phenyl, -NH-CO-benzyl, -CO-NH- benzyl, -NH-8 O ₂ -benzyl, -SO ₂ -NHbenzil, an optionally substituted radical -SO ₂ -NT ¹ T ^2, or CO-NT ¹ T ² where the two radicals T ¹ and T ² may and formylart cyclo amine, or a 3- to 6-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or heterocycle, which may contain up to three different or identical heteroatoms Ο, N, S, or two radicals together are fused, saturated, an unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted or another, optionally substituted nucleus may be fused to that nucleus.

The compound of formula I and also the intermediates for their preparation may have one or more asymmetric

01/283/02 / PB substituted carbon atoms. The compounds may be in the form of pure enantiomers or pure diastereomers or a mixture thereof. It is preferable to use the enantiomerically pure compound as the active ingredient.

The compounds of formula I may also be in the form of physiologically tolerated salts.

The compounds of formula I may also be in the form of a drug precursor in which the compounds of formula I are released under physiological conditions. Reference can be made here, for example, to a group T in the structural element L, which in some cases contains groups which can be hydrolyzed under physiological conditions to the free carboxyl group. Derived structural elements A that release structural element A under physiological conditions are also suitable.

In a preferred embodiment, the compounds of formula I, indices a, e, f and g and heterocycle Q are selected such that the distance between the group T and structural element A is from 10 to 14 atomic bonds, preferably 11 to 13 atomic bonds , along the shortest possible path along the molecular structure.

Other preferred compounds of formula I have preferred structural elements A of formula I _A ¹ , 1A ² , 1A ³ , 1A ⁴ , IA ⁵ , 1A ⁸ , 1A ¹⁰ or 1 _A ¹³ , while the structural elements E, G and L may vary wide as described above.

Other preferred compounds of formula I are particularly preferred

01/283/02 / PB the preferred structural element A of formula 1 _A ⁴ , while the structural elements E, G and L may vary widely as described above.

Especially preferred compounds of formula I have the preferred structural elements A of the formula l _A ^1, lA ^2, lA ³ 1A ⁴ 1A ⁵ 1A ⁸ 1A ¹⁰ or 1 _A ¹³ and the preferred region of the structural element L, while the structural elements E and G may vary widely as described above.

Other particularly preferred compounds of formula I have the particularly preferred structural element A of formula 1 _A ⁴ and the preferred portion of the structural element L, while the structural elements E and G may vary widely as described above.

Other particularly preferred compounds of formula I have the preferred structural element A of formula 1 _A ⁴ and the preferred portion of the structural element E, while the structural elements L and G may vary widely as described above.

Particularly preferred compounds of formula I have the preferred structural element A of formula 1 _A ⁴ as the preferred portion of the structural element E and the preferred portion of the structural element L, while the structural element G may vary widely as described above.

Other particularly preferred compounds of formula I have the preferred portion of structural element A, the preferred portion of structural element E, and the preferred portion of

F1

01/283/02 / PB 38 structural element G, while structural element L may vary widely as described above.

Extremely many preferred compounds of formula I have the preferred structural element A of formula 1 _A ⁴ and the preferred sections of structural elements E, G and L.

Many preferred compounds of formula I are listed in the following table, where '' compound numbers '' stands for the individual compound AEGL compound of formula I, the compound numbers and the corresponding compound are separated by column, and the meaning of the abbreviations of the structural AEGL elements are explained after the table.

01/283/02 / PB

Compound Number: A-E-G-L

1: bhs-25thiaz-nmgly-betaoxaz

2: phhs-24thiaz-bala-betabph

3: bhs-25thiaz-ser-betapy

4: thazep-24thiaz-gly-beta13bendi

5: bim-24thiaz-gly-betatrif

6: bhs-24thioph-gly-betapyee

7: bhs-me25thioph-ala-beta34meoph

8: tolhs-24thioph-gly-betafbph

9: tolhs-24thioph-gly-betameph

10: bim-me24thiaz-bala-betaph

11: bhs-me25thioph-leu-beta34meoph

12: ibhs-24thioph-gly-betathiome

13: bhs-nme35pyr-gly-betabthioph

14: tolhs-nme35pyr-gly-betafu2

15: bhs-ithiadiaz-gly-betahmofu

16: phhs-nme35pyr-bala-betacph

17: impy-24thiaz-bala-betafu3

18: tolhs-25methiaz-bala-psdaptb

19: sabhs-25thiaz-gly-psdap

20: bhs-24thioph-gly-betadcphtb

21: 2py-nme35pyr-leu-psdap

22: bhs-nme35pyr-gly-aspbzla

23: phhs-me24thiaz-gly-zdap

24: bhs-25thiaz-bala-betameph

25: phhs-me24thiaz-ala-beta34meoph

26: tolhs-25methiaz-gly-beta34meoph

27: ibhs-ithiadiaz-gly-betafbph

28: tolhs-ithiadiaz-bala-asppha

01/283/02 / PB

29 phhs-ithiadiaz-bala-betaamibe 30: tolhs-24thioph-bala-betabmph 31 phhs-25methiaz-bala-betaol 32 bhs-25oxaz-bala-betamethi 33 ibhs-24thiaz-bala-betahni 34 gua-24thiaz-gly-betaftrif 35: bhs-24thiaz-gly-betafphe 36 tolhs-oxadiaz-gly-psdaptb 37 phhs-25methiaz-bala-betatbuph 38: bhs-24thiaz-nmgly-betathio3 39: phhs-24thioph-gly-betatos 40: 2py-thiadiaz-leu-psdap 41 dhim-35py-gly-betameph 42 bhs-ithiadiaz-gly-aspaba 43 phhs-oxadiaz-gly-beta4bph 44 bhs-25thiaz-gly-csdap 45: ibhs-25thiaz-gly-betahph 46: phhs-25methiaz-gly-betahdbph 47 bim-me25thioph-gly-betaph 48: ibhs-ithiadiaz-bala-beta3quin 49: tolhs-oxadiaz-gly-betadhbfu 50: bhs-oxadiaz-leu-psdap 51 impy-24thioph-bala-betainyl 52 bhs-25methiaz-ala-beta23meoph 53: phhs-24thiaz-gly-betabnaphth 54 impy-42nmeim-bala-betathiome 55: bim-35thioph-ala-betadcph 56 2py-me24th iaz-g ly-betapy 57 phhs-24thioph-bala-betaimide 58 phhs-24thioph-gly-betadhbfu 59 phhs-nme35pyr-bala-betaibph

01/283/02 / PB

60: bhs-25thiaz-ser-betameph

61: tolhs-25thiaz-bala-zdap

62: bim-25thiaz-gly-betadcph

63: 2 pmhs-42nmeim-gly-betaamibe

64: 2py-24thioph-gly-beta3quin

65: bhs-25methiaz-gly-betamethioph

66: tolhs-ithiadiaz-gly-betafbph

67: phhs-25methiaz-gly-betamethi

68: ibhs-24thiaz-gly-betadtrif

69: bhs-24thioph-gly-betabthioph

70: tolhs-25oxaz-gly-betabmph

71: ibhs-ithiadiaz-bala-suabu

72: bhs-42oxaz-gly-betapy

73: tolhs-ithiadiaz-gly-betapyr

74: 2py-24im-gly-psdap

75: thpy-24thiaz-gly-betadcph

76: phhs-24thiaz-gly-betampy

77: bhs-25methiaz-bala-betadito

78: phhs-25methiaz-bala-suabu

79: bhs-25thiaz-bala-beta23meoph

80: bhs-oxadiaz-leu-betapy

81: tolhs-25oxaz-gly-betabnaphth

82: dhim-25thiaz-ala-zdap

83: tolhs-ithiadiaz-gly-betaimide j ί

84: bhs-ithiadiaz-bala-betaoxaz

85: bim-25thioph-ala-betameph

86: phhs-25oxaz-bala-beta4bph

87: bhs-nme35pyr-nmgly-betainyl

88: phhs-24thiaz-bala-betacbph

89: bhs-25oxaz-bala-betaet}

90: bhs-24thioph-bala-betabmph ii f01 / 283/02 / PB

91: bhs-25oxaz-ala-betaanaphth

92: ibhs-ithiadiaz-gly-betathiobe

93: bhs-25thiaz-bala-betadito

94: 2py-nme35pyr-bala-betapy

95: tolhs-25oxaz-bala-beta3quin

96: bhs-25thiaz-gly-beta23meoph

97: 2py-25methiaz-gly-betadito

98: ibhs-nme35pyr-bala-betahni

99: tolhs-nme35pyr-gly-betadmph

100: ibhs-ithiadiaz-bala-betabdimo

101: 2py-24thiaz-gly-aspibua

102: ibhs-nme35pyr-bala-betacbph

103: bhs-24thiazme-gly-zdap

104: bhs-24thioph-bala-betaol

105: 2py-24im-gly-zdap

106: tolhs-25methiaz-gly-betapytb

107: tolhs-ithiadiaz-gly-psdap

108: phhs-25thiaz-bala-betabthioph

109: bhs-nme35pyr-gly-betafph

110: bhs-25methiaz-ala-betadhbfu

111: bim-25fur-ala-psdap

112: 2 pmhs-24thiaz-gly-betapy

113: bhs-24thiaz-bala-betaphethio

114: bhs-25methiaz-bala-betapytb

115: bhs-25methiaz-bala-betambiph

116: ibhs-25thiaz-gly-betainyl

117: phhs-nme35pyr-bala-betabthioph

118: bhs-25thiaz-bala-betacph

119: bim-26py-ala-betadcph

120: phhs-24thioph-gly-betaphethio

121: gua-24thiaz-gly-betabthioph vimsh>

01/283/02 / PB

122: phhs-24thioph-bala-betaph

123: bhs-25thiaz-gly-betaibph

124: ibhs-nme35pyr-bala-betathio3

125: tolhs-oxadiaz-gly-betapy

126: tolhs-nme35pyr-bala-beta4bph

127: 2py-me24oxaz-gly-betadcph

128: tolhs-25methiaz-bala-psdapee

129: bhs-ithiadiaz-gly-suabu

130: ibhs-25methiaz-bala-beta3quin

131: phhs-25oxaz-gly-betaipr

132: bim-53pyrazo-ala-betadcph

133: tolhs-25oxaz-gly-betapym

134: phhs-25oxaz-gly-betathiobe

135: phhs-me24thioph-ala-betaph

136: tolhs-me25thiaz-leu-betapy

137: hs-25thiaz-bala-betapy

138: bim-42nmeim-leu-betapy

139: tolhs-nme35pyr-bala-betampy

140: bhs-24thioph-gly-betahdcph

141: ibhs-25oxaz-gly-betaimide

142: bhs-oxadiaz-gly-csdap

143: ibhs-25oxaz-gly-betadtrif

144: 2py-53pyrazo-ala-betapy

145: phhs-nme35pyr-gly-betahdbph

146: tolhs-oxadiaz-bala-zdapch

147: phhs-oxadiaz-bala-betapych

148: bim-24thioph-gly-betatrif

149: tolhs-25methiaz-bala-betapyr

150: 2py-24thiaz-ala-betapy

151: bhs-25thiaz-gly-betapytb

152: tolhs-25oxaz-gly-zdapch g

01/283/02 / PB

153: bhs-25methiaz-ala-betadcph

154: ibhs-25methiaz-gly-betatos

155: tolhs-25thiaz-gly-beta35dbph

156: bim-me24thioph-leu-betadcph

157: bim-nme35pyr-gly-aspbzla

158: ibhs-24thioph-bala-ibsdap

159: gua-24thiaz-gly-beta13bendi

160: 2py-25methiaz-gly-psdap

161: 2py-24thiaz-bala-asppha

162: ibhs-ithiadiaz-bala-betaanaphth

163: bhs-nme35pyr-ala-betameph

164: tolhs-oxadiaz-gly-betapym

165: phhs-ithiadiaz-gly-betaph

166: phhs-25methiaz-bala-betadcphtb

167: 2 pmhs-24thiaz-gly-betaph

168: gua-24oxaz-gly-betafbph

169: bhs-25oxaz-phg-betapy

170: bhs-25methiaz-bala-betahdbph

171: 2py-me24thiaz-bala-beta34meoph

172: bhs-25thiaz-bala-betambiph

173: phhs-25methiaz-bala-betadmph

174: bhs-oxadiaz-gly-zdapch

175: dhim-25thioph-gly-betadcph

176: bhs-me25oxaz-gly-zdap

177: ibhs-oxadiaz-gly-betahmo

178: ibhs-25thiaz-gly-betadcph

179: 2py-35fur-gly-zdap

180: bhs-24thiaz-ala-beta13bendi

181: bhs-oxadiaz-gly-betadcph

182: phhs-oxadiaz-bala-betah35dc

183: ibhs-oxadiaz-bala-betaet

01/283/02 / PB phhs-nme35pyr-gly-betadmph phhs-me24thioph-bala-betapy tolhs-25oxaz-gly-beta34dcph bim-26py-gly-betameph ibhs-24thiaz-gly-betadcphee phhs-25thiaz-gly-betacbphph -ithiadiaz-gly-betaphethioa bhs-25methiaz-gly-betafu2 2 pmhs-42nmeim-gly-betabenfu bhs-25methiaz-gly-beta3quin tolhs-25thiaz-bala-betahdcph 2py-24thioph-bala-betadcph 2py-42nmeap-2-al-42nmeim 35thioph-gly-betapy bim-me25thioph-leu-zdap bim-25methiaz-bala-betapy tolhs-25thiaz-bala-betaoxaz phhs-25oxaz-gly-betapbiph tolhs-24thioph-bala-ibsdap bhs-oxadiaz-gly-zdoxbim -leu-betapy ibhs-25methiaz-gly-zdaptb ibhs-25methiaz-gly-betaol tolhs-ithiadiaz-gly-beta34dcph phhs-ithiadiaz-gly-betacthioph phhs-24thiaz-bala-betahmofu phhs-ithiadiaz-gly-asp-thiaz-gly gly-betathioph bhs-25methiaz-gly-betaimide gua-25thiaz-gly-betahdcph bhs-25thiaz-ala-betacph

01/283/02 / PB

215: gua-24thiaz-gly-betaet

216: tolhs-25methiaz-bala-betahcbph

217: tolhs-ithiadiaz-gly-beta35dbph

218: ibhs-oxadiaz-gly-betadbph

219: tolhs-24thioph-gly-betathioph

220: bim-53pyrazo-bala-zdap

221: bim-me24oxaz-gly-betadcph

222: bim-triaz-gly-psdap

223: phhs-25thiaz-bala-betampy

224: bhs-oxadiaz-gly-betadcphee

225: bim-ithiadiaz-leu-zdap

226: 2 pmhs-24thiaz-gly-betafph

227: bhs-25thiaz-gly-betathioph

228: gua-24thiaz-bala-betadcph

229: impy-42nmeim-bala-betafph

230: tolhs-24thioph-gly-betadmoph

231: ibhs-oxadiaz-bala-betapbiph

232: ibhs-25methiaz-bala-zdapee

233: tolhs-oxadiaz-gly-betafph

234: bhs-me24oxaz-bala-beta34meoph

235: tolhs-25methiaz-bala-betahbcph

236: bim-42oxaz-leu-betadcph

237: tolhs-oxadiaz-gly-busu2be

238: tolhs-me25thiaz-ala-betapy

239: phhs-oxadiaz-bala-betainyl

240: bhs-oxadiaz-gly-psdaptb

241: phhs-24thiaz-gly-busu2be

242: tolhs-25methiaz-bala-zdapee

243: bhs-25thiaz-nmgly-betahmph

244: bhs-oxadiaz-gly-betapy

245: phhs-25oxaz-gly-betadcphee

01/283/02 / PB 47

246: phhs-24thiaz-gly-betapy

247: tolhs-ithiadiaz-bala-betamesu

248: bhs-25oxaz-nmgly-beta13bendi

249: phhs-24thiaz-gly-psdapch

250: phhs-25oxaz-bala-asppha

251: phhs-25oxaz-bala-beta3quin

252: phhs-25methiaz-gly-beta3quin

253: phhs-me25oxaz-bala-betadcph

254: phhs-me24thiaz-ala-psdap

255: ibhs-24thioph-gly-betapych

256: phhs-ithiadiaz-bala-betaibph

257: bhs-25oxaz-bala-betaftrif

258: bhs-24thiaz-bala-betahc

259: 2py-me24thioph-leu-psdap

260: phhs-24thioph-gly-betahc

261: dhim-26py-gly-betaheph

262: phhs-oxadiaz-bala-betaphethio

263: bhs-42nmeim-gly-betahni

264: tolhs-nme35pyr-bala-betahb

265: ibhs-nme35pyr-gly-betathiobe

266: tolhs-25oxaz-gly-betapytb

267: 2py-me24oxaz-ala-beta34meoph

268: ibhs-ithiadiaz-gly-betahph

269: bhs-25methiaz-ala-beta13bendi

270: gua-26py-gly-beta3quin

271: phhs-ithiadiaz-gly-betathiobe

272: bhs-oxadiaz-gly-betabpy

273: ibhs-25thiaz-bala-psdapch

274: phhs-ithiadiaz-gly-betacph

275: phhs-24thioph-gly-betabthioph

276: gua-24thiaz-gly-betamesu

01/283/02 / PB

277: tolhs-24thiaz-gly-betambiph

278: bhs-me24oxaz-leu-betaph

279: 2 pmhs-25methiaz-gly-betabpy

280: bhs-ithiadiaz-bala-betathiobe

281: tolhs-25methiaz-bala-betafphe

282: tolhs-24thiaz-bala-betahni

283: ibhs-25thiaz-gly-zdap

284: bhs-25thiaz-ala-betaanaphth

285: ibhs-ithiadiaz-bala-betaphethio

286: ibhs-25oxaz-gly-betaheph

287: 2py-me25thioph-leu-zdap

288: phhs-me24thiaz-bala-betaph

289: bim-me25thioph-bala-betapy

290: 2py-25thiaz-bala-betapy

291: phhs-25thiaz-bala-betatbuph

292: bhs-24thioph-ala-beta13bendi

293: tolhs-25methiaz-bala-betathiobe

294: phhs-25thiaz-bala-beta13bendi

295: bim-nme35pyr-leu-psdap

296: phhs-25methiaz-gly-betatos

297: tolhs-nme35pyr-bala-betaibph

298: phhs-25oxaz-bala-betadcphee

299: hs-24thioph-bala-betapy

300: bim-42nmeim-gly-psdap

301: ibhs-nme35pyr-bala-betambiph

302: bhs-nme35pyr-bala-betahdcph

303: tolhs-ithiadiaz-bala-beta34meoph

304: bhs-25methiaz-ala-betahph

305: bim-53pyrazo-bala-psdap

306: 2 pmhs-25thiaz-gly-betahb

307: 2py-me24thiaz-leu-betadcph

01/283/02 / PB

308: gua-24thiaz-gly-betahmph

309: ibhs-nme35pyr-gly-betaimide

310: phhs-24thiaz-bala-zdaptb

311: tolhs-24thiaz-gly-betaph

312: gua-24thiaz-gly-betahdcph

313: bhs-25methiaz-bala-betapyee

314: 2py-42nmeim-gly-csdap

315: bhs-25oxaz-ala-betadito

316: bhs-nme35pyr-gly-betafu3

317: ibhs-25oxaz-bala-betahdbph

318: phhs-nme35pyr-gly-betabmph

319: phhs-ithiadiaz-bala-betapych

320: bim-24thiaz-leu-psdap

321: bhs-oxadiaz-bala-betadcphee

322: tolhs-ithiadiaz-bala-betaol

323: gua-42pym-gly-betabediox

324: bim-24thiaz-gly-asppha

325: tolhs-24thiaz-gly-betahmofu

326: ibhs-oxadiaz-gly-beta23meoph

327: phhs-me24thioph-ala-zdap

328: phhs-me24oxaz-gly-betaph

329: bhs-25oxaz-nmgly-beta23meoph

330: tolhs-ithiadiaz-bala-betadbph

331: bhs-24im-bala-zdap

332: phhs-oxadiaz-gly-busu2be

333: ibhs-25methiaz-bala-betathio3

334: tolhs-24thiaz-bala-betabdimo

335: bhs-25oxaz-bala-betaipr

336: 2py-me25thiaz-ala-betaph

337: bhs-25methiaz-gly-betapyr

338: tolhs-25oxaz-bala-betainyl

01/283/02 / PB

339: ibhs-25oxaz-gly-betaoxaz

340: tolhs-25thiaz-gly-betapyr

341: phhs-25methiaz-bala-betacbph

342: bhs-24thioph-gly-betadmoph

343: tolhs-oxadiaz-bala-aspbzla

344: dhim-25thioph-gly-zdap

345: phhs-25oxaz-bala-betafph

346: tolhs-25methiaz-bala-betaoxaz

347: ibhs-nme35pyr-bala-aspbzla

348: bhs-oxadiaz-bala-betahcbph

349: phhs-oxadiaz-gly-betameph

350: phhs-me24thioph-leu-betadcph

351: ibhs-nme35pyr-gly-busu2be

352: dhim-24oxaz-ala-zdap

353: 2py-me24oxaz-ala-betaph

354: phhs-ithiadiaz-gly-betampy

355: bhs-ithiadiaz-gly-psdap

356: ibhs-24thioph-gly-aspbzla

357: bim-ithiadiaz-leu-psdap

358: dhim-24thiaz-gly-betahdcph

359: bim-me25oxaz-ala-betadcph

360: gua-24thiaz-gly-betaoxope

361: bim-nme35pyr-ala-betadcph

362: phhs-24thioph-bala-betabthioph

363: 2py-25methiaz-bala-aspbzla

364: tolhs-nme35pyr-gly-betaet

365: bhs-52thiaz-gly-zdap

366: ibhs-oxadiaz-gly-betafbph

367: bhs-24thiaz-gly-betafu3

368: bim-25thiaz-gly-betapy

369: bhs-24thiaz-gly-betah35dc

01/283/02 / PB tolhs-24thiaz-bala-aspibua tolhs-24thioph-bala-betadhbfu tolhs-24thioph-gly-psdapee ibhs-25thiaz-bala-betapym bhs-52thiaz-ala-betainyl ibhs-25oxaz-balah-betadbs -ithiadiaz-gly-betamethioph tolhs-25methiaz-gly-betabpy ibhs-25methiaz-bala-beta35dbph ibhs-25oxaz-bala-beta35dbph bhs-me25thiaz-bala-zdap bhs-25oxaz-gly-asppha bhs-25methiaz-25methiaz 42oxaz-bala-betadcph ibhs-24thiaz-bala-beta3quin bhs-25methiaz-gly-betadcphtb bhs-ithiadiaz-gly-betadcphtb ibhs-25oxaz-bala-betafph tolhs-24thioph-gly-betahmo bhph-24thioph-bhph-24thioph -bala-beta13bendi 2py-24oxaz-bala-zdap phhs-nme35pyr-gly-betadbph bhs-25methiaz-bala-betacph tolhs-25oxaz-gly-betamethioph ibhs-24thiaz-bala-betambiph bhs-24thioph-nmgp-ibs-ngly-ibs bala-betahmph dhim-52thiaz-ala-betameph tolhs-oxadiaz-gly-beta3quin bhs-25methiaz-nmgly-betaoxaz

01/283/02 / PB

401: bhs-oxadiaz-ala-betafphe

402: phhs-25methiaz-gly-betafliio 403: bhs-25oxaz-leu-betadcph 404: tolhs-25methiaz-gly-betaipr 405: dhim-26py-gly-betahcbph 406: bhs-25methiaz-gly-zdapee 407: 2 pmhs-24thioph -gly-betahbcph 408: phhs-ithiadiaz-bala-betahc 409: tolhs-24thiaz-gly-betaipr 410: ibhs-nme35pyr-bala-betainyl 411: bhs-42pym-ala-zdap 412: bhs-25oxaz-bala-betaphethio : impy-25thiaz-gly-betahmofu 414: bhs-25thiaz-bala-betadmph 415: tolhs-me25thioph-ala-betaph 416: bim-24thioph-gly-aspbzla 417: tolhs-nme35pyr-gly-betaheph 418: phhs-25oxaz- bala-betatrif 419: tolhs-24thioph-gly-betathiome 420: ibhs-nme35pyr-gly-betathioph 421: ibhs-25methiaz-gly-betambiph 422: bhs-25oxaz-bala-betacthioph 423: ibhs-24thiaz-gly-csd 2py-ithiadiaz-gly-asppha 425: tolhs-25thiaz-gly-betabdimo 426: tolhs-25thiaz-gly-asap 427: tolhs-25methiaz-bala-betadmoph 428: tolhs-25thiaz-gly-betabediox 429: phhs-25methiaz-gly -betadbph 430: ibhs-oxadiaz-gly-betahni 431: tolhs-24thiaz-bala-betahdbph

01/283/02 / PB

432: phhs-25oxaz-gly-betadmoph

433: phhs-24thiaz-gly-betaomebendi

434: tolhs-ithiadiaz-bala-zdapee

435: tolhs-25oxaz-gly-betathiobe

436: phhs-25oxaz-bala-betaibph

437: 2py-25oxaz-leu-zdap

438: bhs-24oxaz-leu-betadcph

439: bhs-nme35pyr-ala-psdap

440: phhs-oxadiaz-bala-betabediox

441: tolhs-oxadiaz-bala-betapbiph

442: 2py-ithiadiaz-bala-aspaba

443: tolhs-24thiaz-bala-psdaptb

444: bhs-24thiaz-gly-busu2be

445: ibhs-25thiaz-gly-betaoxaz

446: bhs-24thioph-gly-betaphethio

447: bim-35thioph-bala-betapy

448: dimethpym-25methiaz-gly-betameph

449: 2py-ithiadiaz-bala-zdap

450: bhs-25thiaz-nmgly-betabpy

451: 2py-35fur-ala-betapy

452: phhs-25oxaz-gly-betamethioph

453: tolhs-me24thioph-bala-betapy

454: tolhs-ithiadiaz-gly-betafu3

455: gua-26py-gly-betaimide

456: phhs-nme35pyr-bala-betaphethio

457: bhs-25oxaz-gly-aspibua

458: ibhs-oxadiaz-gly-betafph

459: ibhs-oxadiaz-gly-betafu3

460: ibhs-24thiaz-bala-betahcbph

461: tolhs-24thioph-gly-betafluo

462: 2py-24thioph-leu-betapy

01/283/02 / PB impy-25oxaz-gly-ibsdap phhs-nme35pyr-gly-aspbzla 4 pmhs-42nmeim-bala-betadcph tolhs-me25thioph-leu-beta34meoph phhs-oxadiaz-gly-betaoxaz tolhs-nme35pyr-gly-beta-hyphameth-gly-bethax-bh -25thiaz-gly-betaheph phhs-nme35pyr-bala-betaoxaz bhs-24thioph-nmgly-betacph bim-me25oxaz-ala-beta34meoph bhs-25methiaz-gly-betacbph impy-25methiaz-gly-betahmofu dhim-35pyrazo 35fur-ala-zdap phhs-25oxaz-gly-betahc bhs-24thioph-bala-aspibua 2py-24thiaz-gly-betacthioph bhs-oxadiaz-bala-suabu bhs-25methiaz-gly-aspaba tolhs-nme35pyr-gly-betaipad 2py-ith -ala-psdap ibhs-ithiadiaz-bala-betathiobe bhs-nme35pyr-bala-betapyee tolhs-25methiaz-bala-betahc tolhs-25oxaz-gly-zdaptb bhs-24thioph-gly-beta23meoph tolhs-24thioph-bala-bethaphe-pyrhaphype bala-betahbcph phhs-25oxaz-gly-betadbph bhs-25methiaz-bala-asppha ibhs-nme35pyr-gly-psdapch

01/283/02 / PB

494: bhs-oxadiaz-bala-ibsdap 495: bhs-25methiaz-bala-betapy 496: ibhs-24thiaz-gly-betabdimo 497: ibhs-24thiaz-bala-beta34dcph 498: phhs-oxadiaz-gly-betadcphch 499p: bim -gly-betadcph 500: bhs-ithiadiaz-gly-betahc 501: ibhs-ithiadiaz-bala-betathiome 502: bim-me24oxaz-leu-zdap 503: bhs-25oxaz-gly-betadcphee 504: bim-25fur-leu-psdap

505: tolhs-oxadiaz-bala-betatbuph

506: gua-42pym-gly-betadbph

507: ibhs-24thioph-gly-aspaba

508: ibhs-25methiaz-gly-beta34dcph 509: tolhs-ithiadiaz-bala-betahbcph 510: bhs-oxadiaz-nmgly-betaoxaz 511: tolhs-25thiaz-bala-betadbph 512: bhs-oxadiaz-bala-betaomebendi 513-thomebendi 513: th -gly-betameph 514: bhs-ithiadiaz-bala-beta35dbph 515: 2 pmhs-25thiaz-gly-betadtrif 516: ibhs-ithiadiaz-bala-psdapch 517: phhs-24thioph-bala-betaanaphth 518: bhs-25thiaz

519: ibhs-ithiadiaz-bala-betahdcph 520: bhs-42oxaz-ala-zdap 521: tolhs-24thioph-gly-busu2be 522: bhs-ithiadiaz-gly-betaftrif 523: tol hs-n me35pyr-g ly-betad h bfu 524: bhs-24thiaz-gly-aspibua

01/283/02 / PB

525: bhs-24thioph-gly-betapy

526: ibhs-25oxaz-gly-aspbzla

527: tolhs-24thioph-bala-betadbph

528: phhs-25methiaz-gly-betabenfu

529: bhs-nme35pyr-ala-betadito

530: phhs-me25thiaz-ala-beta34meoph 531: ibhs-25methiaz-bala-betamethi

532: ibhs-25oxaz-gly-betahmofu

533: bhs-24thioph-gly-zdapch

534: phhs-24thioph-bala-betah35dc

535: ibhs-24thioph-bala-betahcbph

536: ibhs-ithiadiaz-bala-betahph

537: bhs-ithiadiaz-bala-asppha

538: dhim-25thioph-gly-betameph

539: tolhs-ithiadiaz-gly-betadcphee

540: phhs-oxadiaz-bala-betatbuph

541: bhs-25thiaz-gly-betamethi

542: bhs-ithiadiaz-gly-betahbcph

543: tolhs-25oxaz-bala-betadcphtb

544: phhs-24thiaz-gly-betadhbfu

545: ibhs-25oxaz-gly-psdap

546: ibhs-25methiaz-bala-betatrif

547: bhs-ithiadiaz-bala-beta23meoph

548: phhs-25thiaz-gly-betahmofu

549: bhs-24thioph-gly-betamethi

550: ibhs-25oxaz-gly-betadito

551: bhs-25methiaz-gly-betadcph

552: bhs-me24thioph-ala-psdap

553: tolhs-25thiaz-gly-betahni

554: ibhs-24thioph-gly-betafu3

555: phhs-24thiaz-gly-betahni

01/283/02 / PB

2py-24thioph-gly-aspbzla ibhs-nme35pyr-gly-betaibph tolhs-25methiaz-gly-psdapch bhs-ithiadiaz-gly-betaet bhs-nme35pyr-ala-beta34meoph phhs-oxadiaz-gly-betapyr ibhs-25oxaz-glyox-bisoxh -24oxaz-ala-betaainyl ibhs-nme35pyr-gly-betahmo bhs-25thiaz-nmgly-beta34dcph bhs-nme35pyr-bala-betaomebendi tolhs-25oxaz-gly-betaph bhs-24thiaz-nmgly-betahph bhs-nme35dyrph 24thioph-gly-betahni ibhs-25oxaz-gly-betaftrif phhs-me24thiaz-leu-zdap ibhs-24thiaz-gly-betathiobe phhs-25oxaz-bala-betabediox phhs-ithiadiaz-gly-betameph tolhs-ithiadiaz-gly-ps-ps25diaz-gly-psd -leu-zdap dhim-24oxaz-gly-zdap tolhs-oxadiaz-gly-betapbiph tolhs-24thioph-gly-betadcphch bhs-ithiadiaz-bala-psdapee imhs-25methiaz-gly-zdap bhs-25oxaz-gly-betabnaphth bhs gly-betaftrif phhs-25methiaz-gly-betahmofu phhs-ithiadiaz-bala-betamethi

01/283/02 / PB bhs-ithiadiaz-gly-betabdimo dhim-42pym-gly-betainyl bhs-25thioph-bala-betadcph 2py-thiadiaz-leu-betapy tolhs-25oxaz-bala-betabmph phhs-25oxaz-gly-betadito bim -ithiadiaz-gly-psdap phhs-24thioph-gly-betaibph tolhs-25oxaz-gly-psdapee ibhs-25methiaz-gly-betamesu bhs-oxadiaz-bala-aspaba bhs-oxadiaz-bala-betapym phhs-24thioph-gly-betafu3 tolhs-25thaz 24thioph-gly-betaphethioa ibhs-25oxaz-bala-betafphe tolhs-25oxaz-gly-betacbph ibhs-25methiaz-bala-betaipro bhs-nme35pyr-gly-betaipro tolhs-24thioph-bala-betahmph tolhs-25hmethiaz-25methiaz-25methiaz-25methiaz -gly-betaamibe impy-24thiaz-gly-betabediox ibhs-oxadiaz-gly-betapym 2py-25methiaz-ala-betapy tolhs-nme35pyr-bala-betabnaphth phhs-24thioph-gly-beta4bph ibhs-ithiadiaz-bala-bhaz-bazh-beta-diaz-bazh-beth gly-betaomebendi tolhs-25methiaz-gly-betafph phhs-25oxaz-bala-betadcphtb ibhs-ithiadiaz-gly-beta35dbph

01/283/02 / PB

618: 2py-25oxaz-bala-betadhbfu

619: bhs-25oxaz-gly-betatrif

620: ibhs-25thiaz-gly-zdapch

621: bhs-oxadiaz-gly-betadmoph

622: phhs-nme35pyr-bala-betacthioph

623: phhs-25thiaz-bala-betaoxaz

624: bim-me25oxaz-gly-psdap

625: bhs-25methiaz-ala-betapy

626: ibhs-24thioph-bala-betathioph

627: phhs-25methiaz-gly-suabu

628: phhs-ithiadiaz-bala-betacph

629: phhs-25methiaz-gly-betadmoph

630: phhs-ithiadiaz-bala-zdapch

631: phhs-24thiaz-gly-betabediox

632: bhs-nme35pyr-bala-betatos

633: tolhs-25oxaz-bala-betaipr

634: bhs-24thioph-gly-betapytb

635: bhs-25methiaz-leu-betapy

636: 4 pmhs-24thiaz-gly-betapy

637: tolhs-oxadiaz-bala-betapytb

638: tolhs-oxadiaz-gly-beta34meoph

639: bhs-25oxaz-bala-betatbuph

640: ibhs-25oxaz-gly-suabu

641: phhs-25methiaz-gly-psdaptb

642: tolhs-25oxaz-bala-betahph

643: ibhs-nnme35pyr-gly-betabmph

644: bhs-25oxaz-gly-betadmph

645: ibhs-25oxaz-bala-betabpy

646: phhs-me24thioph-gly-betadcph

647: tolhs-24thioph-bala-betathio3

648: ibhs-25methiaz-bala-psdap

01/283/02 / PB bim-25thiaz-gly-psdap ibhs-25methiaz-gly-betahbcph ibhs-ithiadiaz-gly-betacbph ibhs-25methiaz-gly-betabthioph bi m-me24thioph-g ly-betadcph bhs-oxadiaz betatos phhs-nme35pyr-gly-betabdimo gua-26py-gly-betahmofu ibhs-24thioph-gly-psdaptb phhs-25oxaz-bala-betainyl phhs-24thiaz-bala-betameph bim-25thioph-bala-zdap tolhs-25oxaz-betoxm tolhs-ithiadiaz-gly-betacbph tolhs-25methiaz-bala-beta34meoph bhs-24im-gly-betameph tolhs-oxadiaz-gly-betadcphee phhs-25thiaz-gly-betadmph bhs-nme35pyr-ala-betadmoph ibhs-24thiaz -25oxaz-gly-betameph ph hs-25oxaz-g ly-betatos phhs-25methiaz-bala-beta3quin bim-24oxaz-ala-zdap ibhs-25methiaz-gly-csdap phhs-ithiadiaz-bala-betafph dhim-52thiaz-gly-psdap bhs-24thiaz-ala-zdap ibhs-ithiadiaz-bala-aspibua ibhs-oxadiaz-bala-betahmofu phhs-24thioph-bala-betaoxaz

01/283/02 / PB phhs-25oxaz-bala-busu2be tolhs-25oxaz-bala-ibsdap ibhs-24thioph-gly-betacph bhs-35thioph-ala-betameph 2py-25thioph-gly-betainyl bim-nme35pyr-ala-betapy -25thiaz-bala-aspaba bhs-24thioph-gly-betabenfu phhs-nme35pyr-bala-betabph ibhs-oxadiaz-gly-betatos phhs-ithiadiaz-gly-betamesu 2 pmhs-25oxaz-bala-betabnaphth tolhs-25methiazbe-tolh-25methiaz-tola-busmet 25oxaz-gly-betapyr bhs-ithiadiaz-gly-beta34meoph phhs-24thioph-bala-betampy tolhs-nme35pyr-gly-busu2be bhs-25oxaz-gly-psdap phhs-25oxaz-gly-betaph phhs-me25oxaz-gly-zdap bhs -gly-betahc ibhs-25thiaz-gly-beta23meoph phhs-25methiaz-gly-betabnaphth phhs-24thioph-gly-betabpy tolhs-25oxaz-bala-betatbuph bhs-24thiaz-gly-zdaptb gua-26py-gly-betaph tolhs-me25thiaz bala-betadcph phhs-24thiaz-bala-betabediox ibhs-25methiaz-gly-betathiobe phhs-24thiaz-gly-beta3quin

01/283/02 / PB tolhs-25oxaz-gly-betadmph dhpyrr-25thioph-gly-betadcph phhs-ithiadiaz-gly-betahb hts-42nmeim-gly-zdap dhim-24thiaz-gly-zdap bhs-24thioph-ser-betapy 2py -25fur-bala-betadcph bhs-42nmeim-bala-betaol bhs-25methiaz-bala-betafphe ibhs-25thiaz-bala-betaipr 2py-24thiaz-bala-aspaba phhs-me25thiaz-ala-betadcph phhs-oxadiaz-bala-betad-bala-betad ithiadiaz-bala-betapych phhs-25oxaz-bala-betapych tolhs-24thiaz-bala-betadbph ibhs-25methiaz-gly-betabenfu bhs-25methiaz-gly-beta4bph bhs-ithiadiaz-gly-betameph phhs-24thioph-bhaz-bhas-bhaz-bh -nmgly-ibsdap bhs-oxadiaz-gly-betacbph bhs-nme35pyr-gly-betaftrif phhs-25oxaz-gly-suabu bhs-25methiaz-nmgly-betaanaphth bhs-ithiadiaz-bala-betadbph bim-me25oxph-bet-ph-ph-ph-ph-ph-ph-ph-ph-ph-ph-ph-ph-ph-ph gly-betaoxaz bhs-42oxaz-gly-zdap bhs-24thiaz-nmgly-betahmph ibhs-ithiadiaz-bala-betapytb

01/283/02 / PB

742: bhs-25methiaz-nmgly-betafphe

743: bhs-oxadiaz-ala-beta34meoph

744: bim-53pyrazo-ala-zdap

745: phhs-25methiaz-gly-betadcph

746: phhs-24thioph-gly-zdaptb

747: hts-25oxaz-bala-betadcph

748: 2py-ithiadiaz-ala-betadcph

749: bim-nme35pyr-gly-betapy

750: phhs-oxadiaz-gly-betatrif

751: ibhs-24thiaz-bala-betabnaphth

752: 2py-25methiaz-gly-beta3quin

753: phhs-oxadiaz-bala-betapbiph

754: tolhs-25thiaz-gly-betatrif

755: bim-53pyrazo-gly-betapy

756: bhs-ithiadiaz-nmgly-betabnaphth

757: phhs-25thiaz-gly-betadtrif

758: phhs-nme35pyr-gly-psdapch

759: tolhs-25thiaz-bala-betaomebendi

760: phhs-24thiaz-gly-betaoxope

761: ibhs-oxadiaz-gly-betathio3

762: phhs-oxadiaz-gly-betaph

763: phhs-oxadiaz-bala-betabph

764: bim-me25thiaz-bala-betaph

765: ibhs-oxadiaz-bala-beta4bph

766: bim-me25thiaz-leu-zdap

767: 2py-25methiaz-ala-psdap

768: bhs-42oxaz-ala-betadcph

769: bhs-25methiaz-gly-betainyl

770: bim-triaz-gly-betadcph

771: tolhs-24thiaz-bala-betabthioph

772: bhs-nme35pyr-bala-busu2be

01/283/02 / PB bhs-25oxaz-nmgly-betainyl phhs-me25thiaz-gly-betapy bhs-ithiadiaz-gly-beta4bph phhs-me25thiaz-bala-betadcph bhs-25thiaz-gly-zdap phhs-24thiaz-bala-betah35dc -nme35pyr-bala-betahmofu bhs-24thiaz-bala-betabdimo bim-ithiadiaz-gly-zdap ibhs-24thioph-gly-betadbph bhs-me25oxaz-gly-betapy bhs-24thiaz-ala-beta23meoph ibhs-nme35syr 25oxaz-gly-betaamibe bhs-ithiadiaz-gly-betaoxope gua-25thioph-gly-betacthioph bhs-oxadiaz-gly-betapyr phhs-me25oxaz-ala-beta34meoph bhs-ithiadiaz-gly-betadmph bim-25methiaz-biaz-betahazim-betahaz-betahazim-biaz-betah -bala-betameph ibhs-oxadiaz-bala-betahph phhs-24thioph-gly-betathio3 tolhs-nme35pyr-bala-betapyr ibhs-ithiadiaz-gly-betamethi phhs-24thiaz-bala-beta3quin ibhs-nme35pad-gly-beta-py-gly-beta-py-gly-beta-py-g-beta-py gly-aspbzla bhs-25thiaz-bala-betamesu bim-35fur-bala-zdap tolhs-nme35pyr-gly-betabph

01/283/02 / PB phhs-ithiadiaz-bala-betaphethioa ibhs-nme35pyr-gly-ibsdap bim-24thiaz-leu-betapy thpy-25methiaz-gly-betadcph phhs-24thioph-gly-betabenfu ibhs-25methych-glymethiaz-glymethiaz -oxadiaz-gly-betaph bhs-25thiaz-gly-betaftrif phhs-nme35pyr-bala-betapym tolhs-25thiaz-gly-betameph 2py-25methiaz-bala-betaheph 2py-25methiaz-gly-aspaba phhs-24thiaz-bala-betapych bhs- 35fur-bala-betadcph phhs-ithiadiaz-gly-suabu 2py-42pym-gly-zdap ibhs-ithiadiaz-gly-betaimide tolhs-25oxaz-gly-betahdbph ibhs-25oxaz-bala-betahbcph ibhs-ithiadiaz-balaxazal-oxaz-biaz -gly-ibsdap tolhs-nme35pyr-bala-betabenfu bhs-24thioph-gly-betaphethioa bhs-me25thiaz-bala-betadcph tolhs-me24oxaz-bala-betaph phhs-ithiadiaz-bala-betafbph ibhs-24thiophioph -phithphosph bala-zdap tolhs-oxadiaz-bala-betapym bhs-25oxaz-gly-zdaptb ibhs-ithiadiaz-bala-beta 13bendi

01/283/02 / PB

835: bhs-nme35pyr-bala-betatbuph

836: phhs-oxadiaz-gly-betaphethioa

837: dhim-thiadiaz-gly-betameph

838: bhs-24thioph-nmgly-betacthioph

839: phhs-25methiaz-bala-betaoxaz

840: ibhs-24thiaz-gly-betaimide

841: phhs-24thioph-bala-betabnaphth

842: bhs-24im-bala-betapy

843: tolhs-24thiaz-gly-betabph

844: 2py-25methiaz-gly-aspbzla

845: 2 pmhs-25thiaz-phe-zdap

846: 2 pmhs-24thiaz-gly-betahb

847: bhs-24thiaz-gly-betambiph

848: phhs-25oxaz-gly-psdapch

849: ibhs-24thiaz-gly-beta4bph

850: bim-ithiadiaz-bala-betadcph

851: tolhs-25thiaz-gly-betahdcph

852: bhs-ithiadiaz-bala-betamethioph

853: ibhs-25oxaz-gly-ibsdap

854: ibhs-25oxaz-gly-betabthioph

855: bhs-25methiaz-leu-psdap

856: bhs-25thiaz-bala-betabph

857: tolhs-nme35pyr-bala-betaanaphth

858: bim-me24thioph-leu-betaph

859: thpy-42pym-gly-betadcph

860: thpy-25oxaz-bala-zdap

861: ibhs-ithiadiaz-bala-betahmofu

862: ibhs-oxadiaz-gly-betabph

863: bhs-24thiaz-bala-beta13bendi

864: dhim-24oxaz-ala-betainyl

865: tolhs-nme35pyr-gly-betaoxaz

01/283/02 / PB tolhs-oxadiaz-gly-betathio3 bhs-25fur-gly-zdap bim-24im-ala-psdap ibhs-nme35pyr-bala-betabmph bhs-ithiadiaz-ala-betathio3 tolhs-25thiaz-gly-beta34meoph tolhs -24thioph-gly-betahmofu phhs-25oxaz-gly-zdap 2 pmhs-42nmeim-bala-betabph tolhs-25oxaz-bala-busu2be phhs-ithiadiaz-gly-betathioph bhs-25fur-ala-psdap tolhs-25methiaz-phala-beta-phala-bala-bala-betala oxadiaz-bala-betathiobe ibhs-24thioph-gly-betaibph tolhs-25thiaz-gly-betadito tolhs-25thiaz-gly-betahc tolhs-24thiaz-bala-betabenfu 2py-25thiaz-bala-aspibua impy-25thiaz-gly-betaipr phhs-ithith -bala-beta35dbph phhs-25thiaz-bala-suabu phhs-24thiaz-bala-betapym dhim-52thiaz-gly-zdap ibhs-24thioph-bala-betathiome bim-42nmeim-bala-betadcph tolhs-ithiadiaz-gly-betaoxaz-gly-betaoxaz-gly-betaoxaz bala-betamethi phhs-24thiaz-gly-betaphethioa bhs-ithiadiaz-ala-betacthioph phhs-nme35pyr-bala-betahbcph

01/283/02 / PB phhs-me24thiaz-bala-betadcph hs-25oxaz-gly-betadcph ibhs-25oxaz-gly-beta3quin tolhs-24thioph-bala-betaibph tolhs-24thioph-bala-betahb thazep-24thiaz-gly-betapy ibh -nme35pyr-bala-beta3quin tolhs-25oxaz-bala-betaamibe bhs-oxadiaz-ala-zdap tolhs-24thioph-bala-beta4bph phhs-ithiadiaz-bala-betapbiph gua-42pym-gly-betafph phhs-nme35pyr-gly nme35pyr-bala-beta34dcph phhs-24thiaz-bala-aspibua 2py-25thioph-ala-betameph bim-me25thioph-leu-beta34meoph 2py-me25oxaz-leu-betapy 2py-24thioph-gly-aspibua ibhs-25oxaz-gly-betc -gly-betadcph bhs-24thiaz-bala-betadcphee tolhs-25oxaz-bala-psdapee tolhs-oxadiaz-bala-betaftrif ibhs-oxadiaz-gly-betatbuph bhs-me24oxaz-ala-betadcph tolhs-ithiadaf-bhitha-bisphala bala-zdaptb phhs-25thiaz-bala-betadbph 2py-42oxaz-leu-zdap bhs-oxadiaz-bala-betahmofu

01/283/02 / PB ibhs-25methiaz-gly-betathiome phhs-nme35pyr-bala-betadito phhs-24thioph-gly-beta34meoph tolhs-nme35pyr-bala-betainyl ph hs-me24thioph-g Iy-beta34meoph bim-me25thiaz betadcph bhs-24thiaz-ala-csdap phhs-24thioph-gly-aspbzla bim-25thiaz-gly-betatrif im py-24thioph-gly-betacbph dhpyrr-25methiaz-gly-betapy bhs-24thiaz-bala-betadmoph bhs-42pym psdap phhs-ithiadiaz-bala-betapyee phhs-24thioph-bala-betathiobe bim-35thioph-leu-psdap phhs-me24oxaz-leu-betapy phhs-24thioph-bala-betacph ibhs-25methiaz-bala-betataox tolasx gua-24oxaz-gly-betamethioph tolhs-25methiaz-gly-suabu phhs-24thiaz-bala-betamethi phhs-ithiadiaz-gly-betadhbfu gua-24thiaz-gly-betadbph bhs-25methiaz-nmgly-betabnaphth bhs-24thioph -25thiaz-gly-betacthioph bim-25oxaz-bala-aspaba phhs-ithiadiaz-bala-psdapee tolhs-oxadiaz-bala-busu2be

01/283/02 / PB

959: phhs-me24thiaz-bala-betapy

960: phhs-me24thioph-leu-beta34meoph

961: phhs-24thioph-gly-betapbiph

962: bhs-ithiadiaz-bala-beta34dcph

963: bim-me24thiaz-ala-betaph

964: bhs-nme35pyr-bala-psdapch

965: phhs-24thiaz-bala-betabmph

966: phhs-24thiaz-gly-betadmph

967: bim-triaz-ala-zdap

968: thpym-25oxaz-gly-betameph

969: bim-24thiaz-gly-betaibph

970: tolhs-24thiaz-gly-betaheph

971: tolhs-ithiadiaz-gly-zdaptb

972: bim-26pyrazi-gly-zdap

973: ibhs-24thioph-gly-betaol

974: bim-me25thiaz-gly-betaph

975: ibhs-25methiaz-bala-betadcphch

976: phhs-24thioph-gly-psdapch

977: phhs-24thioph-gly-betahdbph

978: phhs-me25oxaz-gly-betapy

979: dhim-24thiaz-gly-betadcph

980: bim-me24thiaz-ala-betadcph

981: bhs-nme35pyr-gly-betaomebendi

982: phhs-oxadiaz-bala-psdapee

983: bhs-24thioph-bala-betahc

984: ibhs-24thiaz-bala-betathiobe

985: bhs-25methiaz-gly-beta13bendi

986: phhs-oxadiaz-bala-busu2be

987: phhs-ithiadiaz-gly-betafu3

988: phhs-24thioph-gly-betaimide

989: tolhs-25thiaz-bala-beta35dbph

01/283/02 / PB bhs-oxadiaz-gly-betacthioph bhs-ithiadiaz-gly-betapych bim-24oxaz-gly-psdap tolhs-me24thiaz-bala-betapy bhs-25oxaz-gly-betathio3 bi m-oxad iaz-bala- betadcph phhs-nme35pyr-gly-betafu3 dhim-25thiaz-ala-betapy agua-25methiaz-gly-psdap bim-nme35pyr-leu-zdap tolhs-24thiaz-bala-betahmo bim-35fur-bala-psdap bhs-24thiaz-gly dhim-25methiaz-gly-betapy phhs-25methiaz-gly-betapytb 2py-me25oxaz-leu-beta34meoph gua-24thiaz-gly-betapym bim-35fur-leu-zdap bhs-25thioph-leu-betadcph ibhs-25thiaz-bala-beth -24thioph-gly-psdap 2py-35fur-gly-psdap ibhs-oxadiaz-bala-busu2be ibhs-oxadiaz-bala-zdap bhs-25methiaz-gly-betahb tolhs-25oxaz-bala-beta4bph phhs-me24oxaz-bala-beta34meoph 25oxaz-gly-beta4bph bim-35thioph-gly-betadcph bhs-25oxaz-bala-beta3quin impy-25thiaz-gly-betabediox

01/283/02 / PB

1021: bhs-nme35pyr-bala-betabmph

1022: phhs-me24oxaz-gly-beta34meoph

1023: tolhs-24thioph-bala-betaipr

1024: 2py-me25thioph-leu-betadcph

1025: ibhs-24thiaz-bala-betaol

1026: ibhs-24thioph-gly-betatos

1027: phhs-25thiaz-gly-betahni

1028: tolhs-24thioph-bala-betamethi

1029: tolhs-24thiaz-gly-betafu2

1030: ibhs-ithiadiaz-gly-betathioph

1031: 2py-42nmeim-ala-betadcph

1032: phhs-24thioph-bala-aspibua

1033: 2py-25thiaz-gly-zdap

1034: bhs-25thiaz-gly-psdapch

1035: gua-42pym-gly-betadito

1036: ibhs-25oxaz-gly-betahdcph

1037: tolhs-oxadiaz-bala-betathiome

1038: phhs-25thiaz-bala-betaftrif

1039: phhs-ithiadiaz-bala-betabdimo

1040: bhs-nme35pyr-ala-beta13bendi

1041: ibhs-25methiaz-gly-betadtrif

1042: dhim-25thiaz-gly-betainyl

1043: bim-24thiaz-bala-betapy

1044: bhs-25thiaz-nmgly-betathioph

1045: bhs-25thiaz-gly-betatbuph

1046: tolhs-ithiadiaz-gly-aspibua

1047: phhs-ithiadiaz-bala-ibsdap

1048: bhs-24thiaz-bala-zdaptb

1049: ibhs-25methiaz-gly-busu2be

1050: tolhs-oxadiaz-bala-betahmph

1051: phhs-ithiadiaz-gly-csdap

01/283/02 / PB

1052: impy-24thioph-bala-psdap

1053: bim-me25thiaz-leu-psdap

1054: phhs-ithiadiaz-gly-ibsdap

1055: bhs-25methiaz-gly-betah35dc

1056: bhs-25thiaz-met-betameph

1057: tolhs-25methiaz-bala-betainyl

1058: phhs-25thiaz-gly-beta23meoph

1059: phhs-24thioph-gly-betafu2

1060: phhs-me24oxaz-gly-betadcph

1061: tolhs-25thiaz-bala-betah35dc

1062: bhs-24thioph-bala-psdapch

1063: bhs-me24thioph-gly-beta34meoph

1064: tolhs-me24thiaz-ala-betaph

1065: phhs-25methiaz-bala-betaibph

1066: ibhs-ithiadiaz-gly-betadcph

1067: phhs-24thiaz-gly-aspbzla

1068: tolhs-25methiaz-bala-betabdimo

1069: bhs-24thioph-ala-betadmph

1070: gua-42pym-gly-betahcbph

1071: ibhs-25oxaz-bala-betamesu

1072: ibhs-25thiaz-bala-betahcbph

1073: bhs-24thiaz-gly-betabediox

1074: bhs-24thiaz-ala-betamesu

1075: gua-42pym-gly-betaet

1076: bhs-oxadiaz-bala-betathiome

1077: ibhs-25thiaz-gly-betahb

1078: tolhs-ithiadiaz-bala-betadcphtb

1079: bhs-24thiaz-bala-betaoxaz

1080: bhs-24thioph-gly-zdap

1081: bim-nme35pyr-bala-betapy

1082: ibhs-ithiadiaz-gly-beta23meoph

01/283/02 / PB

1083: bhs-25thiaz-ala-beta34meoph 1084: tolhs-me25thioph-bala-betadcph 1085: bhs-ithiadiaz-bala-betaol 1086: phhs-24thiaz-gly-betacbph

1087: phhs-25methiaz-bala-betabenfu 1088: bim-nme35pyr-leu-betapy

1089: 2py-35fur-leu-zdap

1090: ibhs-24thioph-gly-betabpy 1091: tolhs-25thiaz-bala-betathiome 1092: phhs-24thioph-bala-busu2be 1093: tolhs-oxadiaz-gly-betaphethio 1094: dhim-26py-ala-betathioph 1095: phhs-nme -gly-beta34dcph 1096: ibhs-25oxaz-bala-beta23meoph 1097: bhs-25thiaz-ala-zdap

1098: dhthi-24thiaz-bala-betadcph 1099: bhs-nme35pyr-bala-betaoxaz 1100: ibhs-25methiaz-bala-betapytb 1101: ibhs-nme35pyr-gly-betapytb 1102: tolhs-24thiaz-bala-bethams 110 -gly-betafu3 1104: tolhs-oxadiaz-gly-betabenfu 1105: tolhs-nme35pyr-gly-betafbph 1106: bim-ithiadiaz-bala-zdap 1107: gua-25thioph-gly-suabu 1108: bhs-oxadiaz-gly-betathiobe 1109 : phhs-25oxaz-gly-betafluo 1110: 2py-me25oxaz-leu-psdap 1111: ibhs-25oxaz-bala-betahni 1112: ibhs-oxadiaz-gly-betaol 1113: tolhs-25thiaz-gly-betaftrif

01/283/02 / PB

1114: tolhs-25oxaz-bala-betabdimo

1115: tolhs-25oxaz-gly-asppha

1116: bhs-me24thiaz-ala-betaph

1117: tolhs-24thiaz-gly-betafbph

1118: 2py-oxadiaz-gly-psdap

1119: bhs-25thiaz-bala-betahb

1120: bim-35fur-leu-psdap

1121: bhs-ithiadiaz-nmgly-ibsdap

1122: bhs-24oxaz-ala-betameph

1123: bhs-nme35pyr-bala-betapyr

1124: bhs-nme35pyr-ala-betapy

1125: tolhs-24thioph-gly-betaftrif

1126: phhs-25oxaz-gly-betaphethioa

1127: tolhs-nme35pyr-gly-csdap

1128: 2py-25fur-bala-zdap

1129: 2py-24oxaz-leu-psdap

1130: tolhs-24thiaz-bala-zdapch

1131: phhs-oxadiaz-gly-betaoxope

1132: ibhs-24thiaz-bala-betapym

1133: thpym-24thiaz-gly-beta35dbph

1134: phhs-ithiadiaz-bala-betadmph

1135: phhs-me25thiaz-leu-betaph

1136: phhs-nme35pyr-bala-betadcphch

1137: 2py-me24thiaz-bala-betaph

1138: phhs-me24thioph-ala-betapy

1139: ibhs-25thiaz-bala-csdap

1140: tolhs-oxadiaz-bala-betaamibe

1141: ibhs-nme35pyr-gly-betabenfu

1142: bhs-25thiaz-gly-betainyl

1143: bhs-25thiaz-gly-betahdcph

1144: phhs-25thiaz-gly-betacph

01/283/02 / PB

1145: phhs-oxadiaz-gly-betafph

1146: phhs-25oxaz-gly-betapym

1147: tolhs-24thiaz-bala-betacph

1148: 2py-me24thioph-ala-betaph

1149: ibhs-24thiaz-bala-betaipro

1150: hyd-25thiaz-bala-betameph

1151: bim-52thiaz-ala-betapy

1152: bim-me25thiaz-ala-beta34meoph

1153: bhs-oxadiaz-bala-betabmph

1154: dhim-24thiaz-ala-psdap

1155: ibhs-24thioph-bala-zdapee

1156: gua-25thiaz-gly-betahbcph

1157: bhs-ithiadiaz-bala-betabthioph

1158: tolhs-24thiaz-bala-beta13bendi

1159: bim-me24oxaz-ala-beta34meoph

1160: bim-me25oxaz-gly-betapy

1161: 2py-25methiaz-gly-aspibua

1162: bim-25thiaz-leu-betapy

1163: bhs-25thiaz-gly-betah35dc

1164: tolhs-25thiaz-bala-betafbph

1165: bhs-24thioph-bala-csdap

1166: dhim-25thiaz-gly-betahdcph

1167: bhs-25oxaz-nmgly-betacthioph

1168: tolhs-24thiaz-gly-betadcphtb

1169: 2py-25methiaz-bala-psdap

1170: bim-ithiadiaz-gly-betadcph

1171: bim-25fur-gly-psdap

1172: tolhs-ithiadiaz-gly-psdapch

1173: bhs-53pyrazo-gly-betadcph

1174: ibhs-oxadiaz-bala-betahb

1175: bhs-nme35pyr-gly-betaanaphth

01/283/02 / PB

1176: phhs-25thiaz-bala-psdapch

1177: tolhs-oxadiaz-bala-betahmo

1178: tolhs-25methiaz-bala-betathio3

1179: bim-25oxaz-ala-psdap

1180: bim-42nmeim-gly-betapy

1181: ibhs-nme35pyr-bala-betah35dc

1182: tolhs-24thioph-gly-betabthioph

1183: tolhs-25methiaz-bala-betadito

1184: thpym-25thiaz-bala-psdap

1185: bhs-25oxaz-gly-zdap

1186: bhs-25thiaz-phe-betameph

1187: bhs-25methiaz-gly-betathiobe

1188: bhs-nme35pyr-bala-betameph

1189: phhs-ithiadiaz-gly-betaoxope

1190: tolhs-24thiaz-gly-betabpy

1191: phhs-ithiadiaz-bala-psdap

1192: bgua-42nmeim-gly-betadcph

1193: dhim-24oxaz-gly-betamyl

1194: impy-25oxaz-gly-betampy

1195: bhs-25methiaz-bala-betadmoph

1196: gua-24thiaz-gly-betadito

1197: ibhs-ithiadiaz-gly-busu2be

1198: bhs-oxadiaz-bala-betadito

1199: ibhs-24thiaz-bala-betaphethioa

1200: ibhs-ithiadiaz-bala-betatrif

1201: bhs-24thioph-ala-psdap

1202: ibhs-nme35pyr-bala-betahdbph

1203: bhs-24thioph-bala-psdap

1204: 2py-25thiaz-gly-betatbuph

1205: ibhs-24thioph-bala-beta3quin

1206: ibhs-ithiadiaz-bala-betaoxaz

01/283/02 / PB

1207: bhs-me24oxaz-gly-zdap

1208: gua-24thiaz-gly-betah35dc

1209: ibhs-24thioph-gly-betatrif

1210: tolhs-25methiaz-gly-betambiph

1211: thpym-26py-gly-betadcph

1212: phhs-24thioph-bala-betahmph

1213: ibhs-25methiaz-bala-betadmph

1214: tolhs-24thioph-gly-betafphe

1215: tolhs-25oxaz-bala-betabnaphth

1216: bhs-24thioph-gly-betaoxope

1217: pahs-26py-gly-betapy

1218: 2py-24im-gly-betadcph

1219: tolhs-nme35pyr-bala-betapytb

1220: phhs-nme35pyr-gly-betapyee

1221: bhs-25thiaz-bala-betabmph

1222: gua-42pym-gly-betadmoph

1223: ibhs-nme35pyr-bala-betathiome

1224: ibhs-25methiaz-gly-betainyl

1225: bhs-24thiaz-gly-betahcbph

1226: ibhs-24thiaz-bala-psdap

1227: bhs-triaz-ala-zdap

1228: dhim-24thiaz-ala-betameph

1229: ibhs-24thiaz-bala-betapych

1230: ibhs-25methiaz-gly-betaoxope

1231: tolhs-24thiaz-bala-betahbcph

1232: tolhs-24thioph-gly-betathio3

1233: tolhs-oxadiaz-gly-betapych

1234: tolhs-24thiaz-bala-betatbuph

1235: 2py-25oxaz-leu-betadcph

1236: ibhs-24thiaz-gly-betadito

1237: tolhs-25thiaz-bala-betacthioph

01/283/02 / PB

1238: phhs-24thiaz-bala-betaimide

1239: ibhs-25methiaz-gly-betabnaphth

1240: dhim-24oxaz-ala-betameph

1241: phhs-oxadiaz-gly-beta34meoph

1242: 2py-oxadiaz-bala-asppha

1243: phhs-nme35pyr-gly-aspibua

1244: ibhs-nme35pyr-gly-beta13bendi

1245: bhs-oxadiaz-gly-betahb

1246: tolhs-24thioph-gly-beta4bph

1247: ibhs-25oxaz-bala-betah35dc

1248: ibhs-25thiaz-gly-betaoxope

1249: thpym-25thioph-gly-betahcbph

1250: tolhs-25oxaz-bala-betahmofu

1251: bhs-42pym-ala-psdap

1252: bhs-24thiaz-nmgly-betaipro

1253: ibhs-nme35pyr-gly-betahmofu 1254: phhs-ithiadiaz-gly-betapym

1255: ibhs-24thioph-bala-betahbcph

1256: tolhs-oxadiaz-bala-betadcphch

1257: phhs-24thioph-bala-betabmph

1258: phhs-25oxaz-bala-betaftrif

1259: 2py-thiadiaz-ala-betadcph

1260: phhs-me25thiaz-leu-psdap

1261: phhs-nme35pyr-gly-betapych

1262: bhs-oxadiaz-bala-betafu3

1263: 2 pmhs-42nmeim-bala-betameph

1264: ibhs-oxadiaz-bala-betabmph

1265: ibhs-25thiaz-bala-beta23meoph

1266: gua-25thiaz-gly-betaph

1267: bhs-24thiaz-ser-betapy

1268: bhs-24thiaz-met-betadcph

01/283/02 / PB

1269: bhs-ithiadiaz-gly-betacthioph

1270: bhs-42pym-gly-betainyl

1271: 2py-triaz-bala-zdap

1272: 2py-me24oxaz-ala-zdap

1273: phhs-24thioph-bala-betahc

1274: tolhs-24thioph-bala-psdapch

1275: phhs-oxadiaz-gly-betainyl

1276: bhs-25thiaz-nmgly-betamesu

1277: ibhs-24thioph-bala-beta34dcph

1278: phhs-nme35pyr-bala-betameph

1279: phhs-24thioph-bala-betaamibe

1280: 2py-oxadiaz-leu-psdap

1281: bim-25thiaz-ala-betadcph

1282: bim-35thioph-gly-zdap

1283: bim-35py-gly-zdap

1284: ibhs-25oxaz-bala-betapyee

1285: tolhs-me24thiaz-bala-zdap

1286: tolhs-25thiaz-bala-betadito

1287: phhs-oxadiaz-gly-betadtrif

1288: bhs-24thioph-gly-betathiobe

1289: bhs-25thiaz-gly-betaphethioa

1290: tolhs-25oxaz-gly-betahc

1291: bhs-25oxaz-gly-betaimide

1292: tolhs-oxadiaz-bala-betaipr

1293: phhs-24thiaz-gly-betapyr

1294: bhs-me25thioph-gly-betadcph

1295: phhs-nme35pyr-bala-betadmoph 1296: phhs-24thioph-bala-betabpy

1297: phhs-24thioph-bala-beta23meoph

1298: phhs-24thiaz-bala-zdapch

1299: bhs-42oxaz-bala-zdap

01/283/02 / PB

1300: ibhs-ithiadiaz-bala-betadcphee 1301: phhs-nme35pyr-bala-betambiph 1302: bim-42nmeim-bala-betacbph

1303: tolhs-25thiaz-bala-beta34dcph

1304: hs-25methiaz-bala-betapy

1305: dhim-42pym-gly-betapy

1306: bhs-42oxaz-leu-betapy

1307: bhs-24thiaz-nmgly-betadmph

1308: dhim-25thiaz-ala-psdap

1309: phhs-25oxaz-bala-betamethi

1310: phhs-me24thiaz-ala-betaph

1311: ibhs-24thioph-gly-betameph

1312: gua-24oxaz-gly-betaheph

1313: bhs-ithiadiaz-gly-beta13bendi

1314: bhs-ithiadiaz-bala-betahcbph

1315: bhs-nme35pyr-gly-betaheph

1316: bhs-25thiaz-leu-psdap

1317: tolhs-25oxaz-bala-betadmoph

1318: bim-25thiophme-gly-zdap

1319: bhs-nme35pyr-nmgly-betabnaphth

1320: 2py-24thioph-bala-betahni

1321: phhs-oxadiaz-bala-psdapch

1322: ibhs-25thiaz-bala-betabediox

1323: tolhs-25oxaz-gly-betafphe

1324: ibhs-25methiaz-bala-beta4bph

1325: tolhs-25thiaz-gly-betadbph

1326: dhim-26py-gly-zdap

1327: ibhs-24thioph-gly-betacthioph

1328: 2py-ithiadiaz-gly-psdap

1329: tolhs-me25oxaz-ala-betaph

1330: ibhs-nme35pyr-gly-betamethioph

01/283/02 / PB

1331: bhs-ithiadiaz-bala-betabpy

1332: bhs-oxadiaz-bala-betabph

1333: ibhs-oxadiaz-gly-betampy

1334: dhthi-26py-gly-betapy

1335: bhs-25thiaz-gly-betadmph

1336: bim-25methiaz-gly-betaomebendi

1337: tolhs-25thiaz-bala-betadhbfu

1338: bhs-oxadiaz-nmgly-beta34meoph

1339: bim-nme35pyr-bala-asppha

1340: 2py-42nmeim-gly-betafphe

1341: bhs-35thioph-gly-psdap

1342: 2py-42nmeim-bala-betaanaphth

1343: phhs-25thiaz-gly-psdapch

1344: bhs-25methiaz-bala-betabdimo

1345: tolhs-me24oxaz-gly-betaph

1346: ibhs-24thioph-bala-betadito

1347: bhs-24thioph-nmgly-betabnaphth

1348: bhs-oxadiaz-bala-betadcphtb

1349: bhs-26py-ala-psdap

1350: bhs-24thioph-nmgly-betamesu

1351: tolhs-oxadiaz-bala-betaimide

1352: bhs-ithiadiaz-nmgly-betadito

1353: phhs-25methiaz-bala-zdapee

1354: bhs-ithiadiaz-bala-betaphethioa

1355: impy-24thioph-gly-betambiph

1356: bhs-ithiadiaz-gly-betafu2

1357: bhs-ithiadiaz-nmgly-betathioph

1358: phhs-25oxaz-bala-suabu

1359: bhs-25methiaz-bala-betacbph

1360: phhs-me24oxaz-bala-betadcph

1361: dhim-25thiaz-gly-betadtrif

01/283/02 / PB

1362: bhs-24thioph-bala-betathiome

1363: phhs-25oxaz-gly-beta34dcph

1364: tolhs-me25oxaz-bala-betadcph

1365: ibhs-25thiaz-gly-betaamibe

1366: bhs-nme35pyr-nmgly-beta23meoph

1367: 2py-24thiaz-gly-aspaba

1368: gua-24thioph-bala-betadcph

1369: tolhs-24thioph-gly-betamethioph

1370: gua-24thiaz-gly-betaph

1371: 2py-25methiaz-bala-aspibua

1372: ibhs-25oxaz-gly-zdaptb

1373: phhs-me25thiaz-leu-betadcph

1374: bhs-nme35pyr-bala-psdaptb

1375: bhs-25methiaz-gly-betahcbph

1376: ibhs-25methiaz-gly-betah35dc

1377: bhs-24thiaz-bala-aspaba

1378: tolhs-ithiadiaz-bala-beta13bendi

1379: bhs-ithiadiaz-bala-betaph

1380: tolhs-oxadiaz-gly-betaoxope

1381: 2py-thiadiaz-gly-betapy

1382: phhs-24thiaz-bala-betaphethioa

1383: gua-24thiaz-gly-beta35dbph

1384: bim-26py-gly-betainyl

1385: pahs-25thiaz-bala-betameph

1386: bim-thiadiaz-ala-psdap

1387: bhs-me24thiaz-leu-beta34meoph

1388: phhs-25oxaz-gly-betambiph

1389: phhs-oxadiaz-gly-betaomebendi

1390: phhs-25oxaz-bala-betamethioph

1391: dhim-24thiaz-gly-betapy

1392: bim-24thioph-nmala-betadcph uk - * u · · li _, <..

01/283/02 / PB

1393: bhs-nme35pyr-gly-betampy

1394: 2py-me24oxaz-bala-betapy

1395: 2py-25thioph-gly-zdap

1396: ibhs-24thioph-bala-betah35dc

1397: phhs-me25thioph-gly-betadcph

1398: bhs-24thioph-bala-betapym

1399: tolhs-24thioph-gly-aspbzla

1400: ibhs-25thiaz-bala-betapyee

1401: tolhs-nme35pyr-gly-betapyee

1402: bhs-25oxaz-gly-betahdcph

1403: bhs-25oxaz-gly-beta4bph

1404: ibhs-24thiaz-bala-beta4bph

1405: bim-ithiadiaz-bala-betapy

1406: ibhs-nme35pyr-bala-betabdimo

1407: 2py-25thiaz-gly-aspibua

1408: bhs-25oxaz-ala-betabpy

1409: bhs-oxadiaz-gly-betahbcph

1410: bim-me25thioph-leu-betaph

1411: bhs-24thiaz-bala-betadito

1412: dhim-24oxaz-gly-betadcph

1413: tolhs-ithiadiaz-gly-betahcbph

1414: bhs-nme35pyr-leu-betapy

1415: tolhs-nme35pyr-bala-betaol

1416: ibhs-oxadiaz-gly-betapych

1417: tolhs-nme35pyr-gly-betacthioph

1418: tolhs-nme35pyr-bala-aspbzla

1419: 2py-me24thioph-gly-beta34meoph

1420: dhpyrr-24thiaz-gly-betadcph

1421: bhs-24thiaz-gly-betaet

1422: bim-24thiaz-nmala-betadcph

1423: ibhs-nme35pyr-gly-betambiph

01/283/02 / PB

1424: tolhs-ithiadiaz-gly-ibsdap 1425: tolhs-25oxaz-gly-betacthioph 1426: tolhs-24thioph-gly-betadhbfu 1427: bhs-me25thiaz-ala-betaph 1428: phhs-25thiaz-bala-betameph 1429: bhs-24thiaz -ala-beta34dcph 1430: ibhs-nme35pyr-bala-betapyr 1431: 2py-me24thioph-leu-betapy 1432: bhs-24thiaz-bala-betafu2 1433: bhs-ithiadiaz-bala-betaamibe 1434: bhs-25methiazm-ala-ala-35methiaz-ala : bim-me24thiaz-gly-zdap 1436: bim-25methiaz-bala-csdap 1437: 2py-me25oxaz-ala-beta34meoph 1438: phhs-oxadiaz-gly-ibsdap 1439: phhs-25thiaz-bala-betabph 1440: bhs-25methiaz- ala-beta34dcph 1441: tolhs-oxadiaz-bala-betapyee 1442: ibhs-oxadiaz-bala-betaanaphth 1443: tolhs-25oxaz-bala-betathiobe 1444: 2 pmhs-24thiaz-bala-beta4bph 1445: ibhs-ithiadiaz-gly-diaz-14-a: 14 phhs-24thioph-bala-aspaba 1447; tolhs-24thiaz-bala-betaamibe 1448: bhs-25methiaz-gly-betaanaphth 1449: bhs-24thioph-gly-betaph 1450: bhs-oxadiaz-bala-betahb 1451: bhs-52thiaz-gly-betapy 1452: ibhs-oxadiaz-bala -betafluo 1453: phhs-nme35pyr-bala-betadtrif 1454: phhs-25oxaz-bala-betapyr

01/283/02 / PB

1455: bhs-25methiaz-bala-betaipr 1456: ibhs-24thiaz-gly-beta35dbph 1457: ibhs-25thiaz-gly-psdapch 1458: bhs-24thiaz-bala-betatbuph 1459: tolhs-ithiadiaz-bala-betadmoph 1460: i -gly-betaftrif 1461: bhs-25methiaz-ala-betafphe 1462: sabhs-42pym-gly-betapy 1463: phhs-me25thiaz-bala-zdap 1464: phhs-24thiaz-gly-betaibph 1465: 2py-25methiaz-gly-betacthioph 1466 : dhim-25thioph-gly-betapy 1467: bim-me24thiaz-bala-psdap 1468: ibhs-24thioph-gly-betabnaphth 1469: tolhs-25methiaz-bala-betaoxope 1470: sabhs-25oxaz-bala-betameph 1471: tolhs-25meth gly-beta34dcph 1472: ibhs-oxadiaz-bala-betathiome 1473: dhim-42pym-gly-betahdcph 1474: 2py-25thiaz-leu-betapy 1475: ibhs-25thiaz-gly-betah35dc 1476: bhs-25oxaz-bala-betathiobe bhs-oxadiaz-nmgly-betamesu 1478: bhs-oxadiaz-bala-betaol 1479: phhs-oxadiaz-gly-aspbzla 1480: hs-25thiaz-gly-betapy

1481: tolhs-ithiadiaz-bala-betaomebendi 1482: tolhs-25methiaz-bala-beta4bph 1483: phhs-ithiadiaz-bala-csdap

1484: bim-25py-gly-zdap

1485: ibhs-24thioph-gly-betafbph

01/283/02 / PB

1486: impy-25methiaz-gly-betambiph

1487: 2 pmhs-25thiaz-bala-betamethioph

1488: tolhs-24thioph-bala-betafluo

1489: ibhs-ithiadiaz-gly-aspaba

1490: phhs-25methiaz-bala-betacph

1491: bhs-nme35pyr-gly-betatos

1492: dimethpym-25thiaz-gly-betadcph

1493: ibhs-oxadiaz-bala-betaimide

1494: tolhs-24thioph-bala-betaoxope

1495: bhs-nme35pyr-bala-betamethioph

1496: 2py-me24thiaz-leu-betaph

1497: tolhs-nme35pyr-bala-betahni

1498: phhs-oxadiaz-gly-betacthioph

1499: bhs-25thiaz-gly-busu2be

1500: ibhs-oxadiaz-bala-betaipro

1501: tolhs-25thiaz-bala-betadmoph

1502: bhs-25methiaz-ala-betaainyl

1503: bhs-25oxaz-bala-betahcbph

1504: ibhs-ithiadiaz-gly-betacthioph

1505: tolhs-nme35pyr-bala-betaomebendi

1506: phhs-24thioph-bala-betaipr

1507: tolhs-25methiaz-gly-betaoxaz

1508: tolhs-nme35pyr-bala-betaamibe

1509: bhs-25thiaz-bala-betaheph

1510: ibhs-24thioph-gly-asppha

1511: phhs-oxadiaz-bala-betadmoph

1512: 2py-25thiaz-ala-betameph

1513: bhs-thiadiaz-ala-zdap

1514: bhs-24thiaz-bala-betafph

1515: 2 pmhs-25thiaz-bala-betabmph

1516: bhs-24thioph-bala-betafu2

01/283/02 / PB

1517: bim-me25thioph-bala-zdap

1518: bhs-25methiaz-gly-aspibua

1519: bhs-nme35pyr-nmgly-beta34dcph

1520: gua-24thiaz-gly-betafu2

1521: phhs-oxadiaz-gly-betambiph

1522: bhs-24thioph-bala-aspaba

1523: phhs-24thiaz-gly-beta35dbph

1524: ibhs-24thioph-gly-betaipro

1525: bhs-ithiadiaz-bala-psdapch

1526: bhs-25oxaz-gly-betamethioph

1527: bhs-25thiaz-ala-beta34dcph

1528: bhs-ithiadiaz-bala-betaipro

1529: bhs-25oxaz-gly-betah35dc

1530: gua-25thioph-gly-betah35dc

1531: bhs-25oxaz-gly-betabph

1532: bhs-oxadiaz-bala-betaphethio

1533: impy-24thiaz-bala-psdap

1534: bhs-25methiaz-gly-betaol

1535: phhs-25oxaz-bala-betapytb

1536: tolhs-25oxaz-bala-zdaptb

1537: tolhs-nme35pyr-bala-betadcphee

1538: bgua-25thioph-gly-betameph

1539: bhs-oxadiaz-gly-betathio3

1540: ibhs-25thiaz-gly-betahc

1541: gua-24thiaz-gly-betathioph

1542: 2py-53pyrazo-bala-betapy

1543: phhs-ithiadiaz-gly-beta34dcph

1544: dhim-25thioph-ala-betadcph

1545: phhs-25thiaz-gly-betapy

1546: ibhs-25thiaz-bala-betah35dc

1547: phhs-25methiaz-gly-psdap

01/283/02 / PB

1548: bhs-oxadiaz-gly-betafluo

1549: impy-25thiaz-gly-betacbph

1550: 2py-24im-bala-zdap

1551: tolhs-oxadiaz-bala-betahb

1552: phhs-25oxaz-bala-betaoxope

1553: tolhs-25thiaz-gly-betaipr

1554: ibhs-oxadiaz-bala-csdap

1555: ibhs-24thiaz-gly-betampy

1556: bim-thiadiaz-gly-betadcph

1557: 2py-me24thioph-bala-betadcph

1558: bhs-ithiadiaz-nmgly-betadhbfu

1559: phhs-25oxaz-bala-betathioph

1560: ibhs-25oxaz-bala-betaol

1561: bhs-nme35pyr-gly-betaoxope

1562: phhs-ithiadiaz-bala-betathiobe

1563: 2py-25methiaz-leu-zdap

1564: tolhs-25thiaz-gly-betafu2

1565; phhs-24thioph-bala-betahni

1566; ibhs-nme35pyr-gly-betatbuph

1567: ibhs-ithiadiaz-gly-betapbiph

1568: tolhs-oxadiaz-gly-betatos

1569: bim-triaz-bala-betapy

1570: tolhs-25oxaz-bala-betafphe

1571: bhs-ithiadiaz-nmgly-betathio3

1572: 2py-me25thioph-gly-zdap

1573: tolhs-25oxaz-gly-csdap

1574: 2py-thiadiaz-gly-psdap

1575: bhs-52thiaz-gly-betainyl

1576: phhs-ithiadiaz-gly-betahmo

1577: ibhs-25thiaz-gly-betathiome

1578: 2py-oxadiaz-bala-betapy

01/283/02 / PB

1579: 2 pmhs-24thiaz-bala-betathioph

1580: bim-25thiaz-bala-betahc

1581: bim-triaz-leu-psdap

1582: phhs-25methiaz-bala-aspibua

1583: bhs-me24thioph-bala-beta34meoph

1584: phhs-25oxaz-gly-betadcphtb

1585: tolhs-ithiadiaz-gly-beta4bph

1586: ibhs-25oxaz-bala-betamethioph

1587: phhs-ithiadiaz-gly-betah35dc

1588: bhs-25methiaz-gly-betahdbph 1589: gua-25thiaz-gly-betahdbph

1590: 4 pmhs-24thiaz-bala-betameph

1591: bhs-ithiadiaz-gly-betainyl

1592: tolhs-25oxaz-bala-betah35dc

1593: 2py-25fur-bala-psdap

1594: nmhs-24thiaz-gly-psdap

1595: phhs-25methiaz-bala-betadcphee

1596: ibhs-25methiaz-bala-betabph

1597: ibhs-oxadiaz-bala-betabph

1598: ibhs-ithiadiaz-bala-betahbcph

1599: 2py-triaz-ala-zdap

1600: bhs-nme35pyr-nmgly-beta3quin

1601: dhim-25thioph-ala-zdap

1602: bhs-me24oxaz-leu-beta34meoph

1603: phhs-25methiaz-gly-aspaba

1604: bhs-nme35pyr-bala-betadtrif

1605: tolhs-24thioph-bala-betadtrif

1606: bhs-25methiaz-bala-betahb

1607: 2py-24thiaz-ala-betainyl

1608: bhs-25thiaz-gly-betaph

1609: tolhs-oxadiaz-bala-betabediox nNMM

01/283/02 / PB

1610: bhs-oxadiaz-bala-betaoxope

1611: bhs-25thiaz-nmgly-betaanaphth

1612: phhs-24thioph-gly-betadmph

1613: phhs-25methiaz-gly-betainyl

1614: gua-24thiaz-gly-betadcph

1615: bhs-24thioph-bala-betadcphee

1616: phhs-ithiadiaz-gly-betabph

1617: bhs-thiadiaz-ala-betapy

1618: bim-me25oxaz-leu-psdap

1619: 2py-me24thioph-bala-betaph

1620: tolhs-nme35pyr-bala-betabediox

1621: bhs-25methiaz-ala-beta34meoph

1622: tolhs-ithiadiaz-gly-betadmoph

1623: bhs-24thiaz-nmala-betapy

1624: 2py-triaz-leu-betadcph

1625: ibhs-24thioph-bala-betaibph

1626: phhs-me25oxaz-ala-betaph

1627: gua-24oxaz-gly-betaph

1628: phhs-ithiadiaz-gly-betapych

1629: bhs-me24oxaz-leu-zdap

1630: ibhs-25thiaz-bala-betamethi

1631: bim-42oxaz-leu-psdap

1632: bhs-25thiaz-hphe-betameph

1633: bhs-nme35pyr-nmgly-betabpy

1634: 2 pmhs-25thiaz-bala-beta13bendi

1635: ibhs-ithiadiaz-gly-zdapch

1636: tolhs-oxadiaz-gly-psdapee

1637: bhs-25oxaz-ala-betainyl

1638: tolhs-25thiaz-bala-suabu

1639: bim-24thiaz-leu-betadcph

1640: bhs-24thioph-gly-beta34dcph

01/283/02 / PB

1641: tolhs-oxadiaz-gly-aspaba

1642: phhs-25thiaz-gly-betathiome

1643: phhs-24thioph-bala-psdaptb

1644: phhs-nme35pyr-bala-betabediox

1645: tolhs-oxadiaz-gly-betahcbph

1646: bhs-ithiadiaz-bala-betaomebendi

1647: phhs-24thioph-bala-betahph

1648: 2py-me25thioph-ala-psdap

1649: 2py-24thiaz-leu-betapy

1650: 2py-25oxaz-gly-aspibua

1651: sabhs-24thiaz-gly-betapy

1652: phhs-25oxaz-gly-betahbcph

1653: tolhs-25methiaz-bala-betabph

1654: bhs-ithiadiaz-bala-aspibua

1655: dhim-26py-gly-betaoxaz

1656: ibhs-oxadiaz-gly-beta4bph

1657: bhs-24thiaz-nmgly-beta3quin

1658: phhs-25methiaz-gly-betabph

1659: tolhs-25methiaz-gly-betathiobe

1660: bhs-25thiaz-bala-zdapee

1661: bim-24thiaz-bala-zdap

1662: 2 pmhs-42nmeim-ser-psdap

1663: phhs-24thiaz-gly-betathio3

1664: bhs-24thioph-nmgly-beta13bendi

1665: phhs-25methiaz-gly-betaheph

1666: tolhs-25thiaz-gly-betaet

1667: tolhs-me24thioph-ala-betadcph

1668: ibhs-25oxaz-bala-betaipr

1669: phhs-me25thioph-ala-zdap

1670: ibhs-25thiaz-bala-betambiph

1671: tolhs-me25thioph-ala-beta34meoph

01/283/02 / PB

1672: ibhs-25thiaz-gly-betaphethio

1673: phhs-24thiaz-bala-betaomebendi

1674: ibhs-24thiaz-gly-beta34meoph

1675: bim-35fur-bala-betapy

1676: tolhs-25thiaz-gly-zdapee

1677: ibhs-25oxaz-gly-betatrif

1678: phhs-oxadiaz-gly-betamethioph

1679: 2py-thiadiaz-bala-zdap

1680: bhs-24thioph-bala-zdapch

1681: bhs-25methiaz-bala-betafu2

1682: ibhs-oxadiaz-gly-psdap

1683: bhs-oxadiaz-gly-betapyee

1684: bhs-me24thioph-gly-zdap

1685: bim-me25oxaz-ala-zdap

1686: bhs-25methiaz-gly-betaomebendi

1687: tolhs-25thiaz-bala-betahb

1688: 2py-24thioph-bala-beta34dcph

1689: ibhs-oxadiaz-bala-betapych

1690: ibhs-24thioph-gly-betafu2

1691: bhs-25oxaz-ala-beta3quin

1692: bhs-24thioph-bala-betabediox

1693: phhs-nme35pyr-gly-betapy

1694: ibhs-ithiadiaz-gly-betamesu

1695: bhs-25methiaz-gly-betabediox

1696: phhs-25thiaz-gly-betafu2

1697: 2py-24thiaz-bala-betaheph

1698: phhs-oxadiaz-gly-asppha

1699: ibhs-ithiadiaz-bala-psdap

1700: thpym-25methiaz-bala-psdap

1701: tolhs-25oxaz-bala-betabenfu

1702: ibhs-ithiadiaz-gly-betathio3

01/283/02 / PB

1703: bhs-25methiaz-gly-betampy

1704: bim-52thiaz-gly-betameph

1705: tolhs-nme35pyr-gly-beta23meoph

1706: bhs-ithiadiaz-bala-betaftrif

1707: bhs-25oxaz-gly-betadmoph

1708: phhs-24thiaz-gly-betainyl

1709: ibhs-25thiaz-gly-betaanaphth

1710: phhs-ithiadiaz-bala-betaphethio

1711: phhs-25thiaz-bala-betahdcph

1712: 4 pmhs-25oxaz-gly-betapy

1713: bhs-53pyrazo-ala-betapy

1714: phhs-nme35pyr-bala-betathioph

1715: bhs-nme35pyr-nmgly-betamesu

1716: phhs-25oxaz-gly-betampy

1717: 2py-25oxaz-bala-betaphethioa

1718: bhs-25methiaz-bala-betafu3

1719: phhs-me24oxaz-leu-betadcph

1720: bhs-25thiaz-ala-ibsdap

1721: bhs-ithiadiaz-gly-betabmph

1722: bhs-ithiadiaz-bala-betadmoph

1723: phhs-25thiaz-gly-betatbuph

1724: 2py-42pym-ala-psdap

1725: ibhs-nme35pyr-gly-betaoxaz

1726: phhs-24thioph-bala-betafu3

1727: phhs-25oxaz-bala-betapbiph

1728: 2py-me25oxaz-ala-betapy

1729: phhs-me24thiaz-gly-betaph

1730: bhs-25methiaz-nmgly-betaipro

1731: phhs-me24thiaz-leu-psdap

1732: gua-42pym-gly-betaphethio

1733: bhs-24thioph-gly-betaoxaz

01/283/02 / PB

1734: bhs-oxadiaz-bala-betahc

1735: ibhs-nme35pyr-gly-betainyl

1736: tolhs-nme35pyr-bala-psdaptb

1737: bhs-oxadiaz-bala-betadmph

1738: phhs-ithiadiaz-gly-betafbph

1739: phhs-25thiaz-gly-betahcbph

1740: tolhs-25oxaz-bala-betaibph

1741: tolhs-25oxaz-gly-betapych

1742: bhs-24thiaz-nmgly-betabnaphth

1743: phhs-25methiaz-gly-zdap

1744: 2py-42nmeim-gly-betaipro

1745: bhs-24thioph-bala-betafph

1746: ibhs-24thioph-bala-betambiph

1747: 2 pmhs-42nmeim-gly-betahdcph

1748: 2py-24thiaz-gly-zdap

1749: phhs-oxadiaz-bala-betamethi

1750: bhs-me25thiaz-bala-betaph

1751: bhs-triaz-ala-betadcph

1752: bhs-25methiaz-bala-betahmofu

1753: bhs-25thiaz-ala-betafphe

1754: phhs-oxadiaz-bala-betafluo

1755: phhs-24thiaz-bala-betabenfu

1756: 2py-24thiaz-bala-aspbzla

1757: bhs-24thiaz-ala-psdap

1758: phhs-oxadiaz-gly-betapyee

1759: tolhs-25thiaz-bala-betaph

1760: ibhs-24thioph-bala-betaheph

1761: tolhs-24thioph-bala-zdaptb

1762: tolhs-24thiaz-gly-zdapee

1763: ibhs-ithiadiaz-bala-betaomebendi

1764: phhs-ithiadiaz-bala-betamethioph

01/283/02 / PB

1765: phhs-nme35pyr-bala-betathiobe

1766: phhs-25thiaz-bala-betafphe

1767: ibhs-25thiaz-bala-beta34dcph

1768: phhs-24thiaz-gly-psdaptb

1769: tolhs-24thioph-gly-betatos

1770: gua-26py-gly-betamethi

1771: bhs-oxadiaz-gly-betahmofu

1772: impy-42nmeim-gly-betahph

1773: bhs-24thiaz-bala-betadcphtb

1774: tolhs-ithiadiaz-gly-busu2be

1775: bim-me24oxaz-bala-beta34meoph

1776: tolhs-25methiaz-gly-betafu3

1777: tolhs-25oxaz-bala-aspbzla

1778: bhs-oxadiaz-ala-betacph

1779: phhs-ithiadiaz-bala-aspbzla

1780: ibhs-25thiaz-bala-betaph

1781: tolhs-oxadiaz-bala-csdap

1782: ibhs-oxadiaz-gly-betadtrif

1783: ibhs-25thiaz-gly-betadito

1784: tolhs-25oxaz-bala-suabu

1785: bhs-ithiadiaz-bala-zdap

1786: bhs-25thioph-gly-psdap

1787: 2py-24im-ala-zdap

1788: 2 pmhs-25methiaz-gly-betaph

1789: phhs-25oxaz-gly-psdap

1790: bhs-24thioph-bala-betabenfu

1791: bim-me25oxaz-gly-betadcph

1792: bhs-oxadiaz-bala-betahmph

1793: ibhs-ithiadiaz-bala-betafph

1794: ibhs-25oxaz-bala-betacph

1795: ibhs-25methiaz-gly-betaipro

01/283/02 / PB

1796: ibhs-24thiaz-gly-betabph

1797: 2py-triaz-leu-betapy

1798: tolhs-nme35pyr-gly-zdapch

1799: bhs-thiadiaz-leu-betadcph

1800: tolhs-ithiadiaz-bala-beta34dcph

1801: phhs-25oxaz-bala-betampy

1802: tolhs-nme35pyr-gly-betabediox

1803: phhs-24thiaz-gly-betabenfu

1804: ibhs-24thioph-gly-betaanaphth

1805: ibhs-24thiaz-bala-betabthioph

1806: bhs-24thiaz-gly-betameph

1807: bhs-24thioph-bala-betaph

1808: ur-25oxaz-bala-zdap

1809: phhs-25thiaz-gly-betadcph

1810: ibhs-24thiaz-gly-betaphethio

1811: agua-24thioph-gly-psdap

1812: tolhs-24thiaz-bala-betadmoph

1813: phhs-nme35pyr-gly-betaheph

1814: bhs-ithiadiaz-gly-aspbzla

1815: cima-25methiaz-bala-psdap

1816: bim-25thiaz-bala-aspaba

1817: phhs-oxadiaz-bala-betahcbph

1818: phhs-me24thiaz-ala-betadcph

1819: bim-25oxaz-gly-betafph

1820: bhs-25methiaz-gly-betabenfu

1821: gua-42pym-gly-betabph

1822: bim-24thioph-bala-asppha

1823: ibhs-oxadiaz-bala-betamethi

1824: tolhs-24thiaz-bala-betabediox

1825: tolhs-25oxaz-bala-psdap

1826: ibhs-25thiaz-bala-beta35dbph

01/283/02 / PB

1827: ibhs-25oxaz-gly-betamesh 1828: ibhs-24thioph-gly-betambiph 1829: bhs-25oxaz-gly-betahcbph 1830: ibhs-24thioph-gly-betahc 1831: 2py-25methiaz-gly-asppha 1832: phhs-oxadiaz -gly-betacbph 1833: ibhs-ithiadiaz-bala-betaipro 1834: bhs-25thiaz-ala-betacthioph 1835: phhs-25thiaz-gly-aspibua 1836: ibhs-25methiaz-bala-betamesu 1837: bim-42nmeim-bala-betab 18 : tolhs-me25thioph-gly-betadcph 1839: ibhs-25methiaz-bala-betafbph 1840: phhs-25oxaz-gly-beta35dbph 1841: phhs-24thioph-bala-betaet 1842: ibhs-25oxaz-gly-betadcphee 1843: phhs gly-betadtrif 1844: hs-42nmeim-bala-zdap 1845: bim-25methiaz-gly-betaibph 1846: bim-thiadiaz-ala-betapy 1847: 2py-me24im-ala-betapy

1848: bhs-24thiaz-gly-betamethioph

1849: tolhs-24thiaz-gly-beta23meoph 1850: tolhs-nme35pyr-bala-zdaptb 1851: ibhs-nme35pyr-gly-betah35dc 1852: bhs-25thiaz-gly-betahph 1853: bhs-25thiaz-bala-betatbuph 1854: ur-24thth -gly-betadcph 1855: tolhs-me25thiaz-gly-psdap 1856: ibhs-24thiaz-gly-betafu2

1857: bhs-ithiadiaz-gly-betathiobe

01/283/02 / PB

1858: bim-25fur-bala-betapy

1859: phhs-25thiaz-gly-betahmph

1860: tolhs-nme35pyr-bala-betadbph

1861: ibhs-oxadiaz-bala-betamesu

1862: ibhs-25oxaz-bala-betabediox

1863: tolhs-oxadiaz-bala-betabnaphth

1864: bhs-oxadiaz-bala-zdapee

1865: ibhs-24thiaz-bala-betafph

1866: tolhs-25methiaz-bala-betaibph

1867: bhs-24thioph-gly-betatrif

1868: 3 pmhs-42nmeim-bala-zdap

1869: phhs-nme35pyr-gly-betathioph

1870: tolhs-nme35pyr-bala-busu2be

1871: bhs-24thiaz-gly-betaoxope

1872: tolhs-24thiaz-gly-betatrif

1873: bhs-25methiaz-gly-betahmo

1874: tolhs-oxadiaz-gly-betahph

1875: phhs-ithiadiaz-gly-zdaptb

1876: bim-42nmeim-bala-betahmofu

1877: 2py-thiadiaz-gly-zdap

1878: bhs-ithiadiaz-gly-betahmo

1879: bim-25thiaz-gly-aspibua

1880: bhs-nme35pyr-gly-betapy

1881: bhs-ithiadiaz-ala-betapy

1882: ibhs-nme35pyr-bala-betafphe

1883: bhs-53pyrazo-bala-betadcph

1884: ibhs-25methiaz-gly-betahcbph

1885: tolhs-25methiaz-gly-betaphethio

1886: bhs-24thiaz-bala-beta23meoph

1887: ibhs-nme35pyr-gly-zdap

1888: bhs-25thiaz-gly-betadcphtb

01/283/02 / PB

100

1889: gua-26py-gly-betacbph

1890: 2py-25thiaz-gly-betathio3

1891: tolhs-24thioph-bala-betapyee

1892: bhs-oxadiaz-gly-betaoxaz

1893: ibhs-25thiaz-bala-betahdbph

1894: ibhs-ithiadiaz-bala-betaheph

1895: ibhs-24thiaz-gly-betahmofu

1896: tolhs-24thioph-bala-betaoxaz

1897: phhs-25methiaz-gly-betapbiph

1898: tolhs-24thiaz-gly-betamethi

1899: tolhs-24thiaz-bala-betamethioph

1900: bhs-ithiadiaz-bala-betapyee

1901: bhs-25thiaz-bala-zdaptb

1902: ibhs-nme35pyr-bala-beta34meoph

1903: tolhs-me25thioph-ala-zdap

1904: ibhs-25methiaz-gly-betaamibe

1905: phhs-25oxaz-bala-betabdimo

1906: 2py-triaz-gly-betapy

1907: ibhs-25oxaz-bala-betadcphch

1908: bhs-oxadiaz-nmgly-betadmph

1909: bhs-24thiaz-bala-beta35dbph

1910: tolhs-24thioph-gly-betapy

1911: gua-26py-gly-betacthioph

1912: bhs-25oxaz-bala-betapy

1913: dhpyrr-25thiaz-gly-betapy

1914: tol hs-24th ioph-bala-betapym

1915: ibhs-24thioph-bala-betapbiph

1916: gua-26py-gly-betaipro

1917: bim-oxadiaz-bala-aspibua

1918: tolhs-nme35pyr-bala-betadtrif

1919: tolhs-25thiaz-gly-betafluo

01/283/02 / PB

101

1920: phhs-oxadiaz-bala-beta23meoph 1921: tolhs-25oxaz-bala-beta34dcph 1922: 2py-me24oxaz-ala-betapy

1923: tolhs-25methiaz-gly-betapym

1924: phhs-nme35pyr-gly-betahdcph

1925: tolhs-oxadiaz-gly-betafbph

1926: tolhs-25methiaz-bala-csdap

1927: bhs-24im-gly-psdap

1928: 2py-me25oxaz-bala-beta34meoph

1929: ibhs-25oxaz-gly-betahdbph

1930: ibhs-oxadiaz-bala-betahcbph

1931: phhs-24thioph-bala-csdap

1932: tolhs-24thiaz-gly-betameph

1933: bhs-24thioph-gly-betacbph

1934: ibhs-24thiaz-gly-psdapee

1935: phhs-24thiaz-gly-betafluo

1936: gua-42pym-gly-betacthioph

1937: bhs-25thiaz-bala-betadhbfu

1938: bhs-oxadiaz-bala-betadhbfu

1939: phhs-25methiaz-gly-busu2be

1940: phhs-24thiaz-gly-psdap

1941: ibhs-24thioph-bala-betathiobe

1942: phhs-ithiadiaz-gly-betatbuph

1943: tolhs-25methiaz-bala-betahmofu

1944: sabhs-24thioph-gly-psdap

1945: ibhs-25oxaz-gly-betaoxope

1946: tolhs-25thiaz-gly-beta34dcph

1947: phhs-nme35pyr-gly-betabph

1948: phhs-25thiaz-gly-betatrif

1949: bhs-ithiadiaz-ala-betadito

1950: bim-25thiaz-ala-betameph

01/283/02 / PB

102

1951: 2py-35fur-gly-betadcph

1952: ibhs-25methiaz-gly-betabdimo

1953: cima-24thioph-bala-psdap

1954: phhs-24thioph-gly-betafph

1955: ibhs-ithiadiaz-bala-betafphe

1956: bim-24im-leu-betapy

1957: bhs-25thioph-gly-betacph

1958: impy-24thiaz-bala-betainyl

1959: bim-25methiaz-bala-asppha

1960: bhs-24thioph-bala-betadcphtb

1961: ibhs-oxadiaz-bala-psdaptb

1962: 2py-me24thioph-gly-psdap

1963: 2 pmhs-24thiaz-bala-betamethioph

1964: ibhs-25methiaz-bala-betampy

1965: bhs-24thiophme-gly-betameph

1966: bhs-ithiadiaz-gly-betatrif

1967: dhim-26py-ala-betatbuph

1968: thpym-25thiaz-gly-betadcph

1969: 2py-thiadiaz-ala-betapy

1970: 2py-25methiaz-bala-betaoxope

1971: tolhs-25methiaz-gly-ibsdap

1972: ibhs-ithiadiaz-gly-betaoxaz

1973: phhs-25thiaz-bala-asppha

1974: 2py-42nmeim-gly-betampy

1975: 2py-26py-ala-betapy

1976: phhs-24thiaz-gly-betadcphtb

1977: 3 pmhs-24thioph-bala-betapy

1978: 2py-25thiaz-bala-aspbzla

1979: gua-42pym-gly-betahmo

1980: gua-26py-gly-betaamibe

1981: tolhs-25methiaz-gly-zdapee

01/283/02 / PB

103

1982: ibhs-25oxaz-gly-psdapch

1983: bhs-25thiaz-nmgly-betadmph

1984: bhs-nme35pyr-bala-betadmoph

1985: agua-25thiaz-gly-betadcph

1986: phhs-25methiaz-gly-betameph

1987: bhs-24thiaz-gly-beta35dbph

1988: ibhs-ithiadiaz-gly-betafphe

1989: bim-25oxaz-leu-betapy

1990: phhs-ithiadiaz-bala-betahmph

1991: 2py-24thioph-bala-betaet

1992: 2py-me24thiaz-gly-betaph

1993: 2py-24im-ala-betadcph

1994: bhs-25thiaz-gly-betadmoph

1995: phhs-ithiadiaz-bala-betaet

1996: ibhs-25thiaz-bala-betaphethio

1997: phhs-oxadiaz-bala-betahbcph

1998: ibhs-25methiaz-bala-betafphe

1999: ibhs-25thiaz-gly-suabu

2000: bim-24thiaz-ala-betameph

2001: phhs-me25thiaz-bala-betaph

2002: ibhs-25thiaz-gly-betapyr

2003: bhs-me25thioph-bala-betaph

2004: bhs-25oxaz-bala-aspaba

2005: 2 pmhs-25thiaz-bala-betathioph

2006: tolhs-oxadiaz-bala-psdap

2007: bhs-nme35pyr-gly-betaoxaz

2008: tolhs-25thiaz-gly-beta23meoph

2009: phhs-25methiaz-gly-betaamibe

2010: gua-25thioph-gly-betapy

2011: 2py-nme35pyr-gly-psdap

2012: ibhs-ithiadiaz-gly-betahdbph

01/283/02 / PB

104

2013: 2py-25oxaz-gly-betacbph

2014: bim-me24thioph-leii-zdap

2015: bhs-25thiaz-ala-beta13bendi

2016: phhs-24thioph-gly-betatrif

2017: 2py-ithiadiaz-gly-betapy

2018: phhs-nme35pyr-gly-betapytb

2019: ibhs-ithiadiaz-gly-betaanaphth

2020: bhs-nme35pyr-ala-betaanaphth

2021: tolhs-nme35pyr-gly-betapych

2022: 2py-me25thioph-bala-psdap

2023: ibhs-24thiaz-gly-betaet

2024: tolhs-24thioph-gly-beta3quin

2025: tolhs-24thiaz-bala-betaoxope

2026: ibhs-25methiaz-gly-beta34meoph

2027: ibhs-25oxaz-bala-betambiph

2028: phhs-25oxaz-gly-betafbph

2029: tolhs-24thiaz-gly-betathio3

2030: phhs-ithiadiaz-gly-betaipro

2031: phhs-25oxaz-gly-betacthioph

2032: bhs-25thiaz-bala-betaibph

2033: impy-24thioph-nmgly-psdap

2034: bhs-24im-gly-zdap

2035: bhs-thiadiaz-leu-betapy

2036: gua-25thiophme-gly-betapy

2037: bhs-24thiaz-gly-betafluo

2038: tolhs-oxadiaz-bala-betathioph

2039: bhs-24im-ala-betapy

2040: bhs-24thiaz-bala-betabph

2041: bim-25oxaz-bala-betathioph

2042: bhs-nme35pyr-gly-betaamibe

2043: phhs-25oxaz-gly-beta23meoph

01/283/02 / PB

105

2044: ibhs-ithiadiaz-gly-betabdimo

2045: phhs-25methiaz-gly-betaipro

2046: phhs-24thiaz-gly-beta34meoph

2047: phhs-25thiaz-gly-betafluo

2048: bhs-25methiaz-bala-betaanaphth

2049: tolhs-25thiaz-bala-psdapee

2050: tolhs-24thiaz-gly-betafphe

2051: bhs-24thioph-gly-betafluo

2052: phhs-nme35pyr-gly-betahni

2053: 2py-me24thioph-bala-betapy

2054: ibhs-25methiaz-gly-betafbph

2055: 2py-nme35pyr-bala-aspaba

2056: bhs-24thiaz-gly-betatbuph

2057: 2py-42pym-gly-betapy

2058: tolhs-24thiaz-bala-betahmofu

2059: ibhs-25thiaz-gly-betatos

2060: ibhs-nme35pyr-bala-suabii

2061: ibhs-25methiaz-gly-betamethioph

2062: ibhs-25thiaz-bala-betadito

2063: hyd-24thiaz-bala-betameph

2064: tolhs-nme35pyr-gly-betacph

2065: bhs-25oxaz-ala-betafphe

2066: bhs-oxadiaz-gly-aspbzla

2067: tolhs-24thiaz-bala-ibsdap

2068: bim-ithiadiaz-leu-betadcph

2069: 2py-24thioph-gly-betaol

2070: tolhs-24thiaz-gly-betamesu

2071: ibhs-24thiaz-gly-betahdcph

2072: bhs-25methiaz-nmgly-beta3quin

2073: ibhs-24thioph-gly-betaphethio

2074: bhs-24thioph-bala-betathiobe

01/283/02 / PB

106

2075: bhs-25thiaz-gly-asppha

2076: phhs-nme35pyr-bala-betaphethioa

2077: 2py-25methiaz-leu-betadcph

2078: tolhs-ithiadiaz-bala-betafphe

2079: bhs-25oxaz-bala-betadmph

2080: bhs-nme35pyr-bala-betaftrif

2081: tolhs-25methiaz-gly-betapyee

2082: bim-oxadiaz-leu-psdap

2083: tolhs-ithiadiaz-gly-betahc

2084: gua-25thiaz-gly-betahc

2085: 2py-53pyrazo-gly-zdap

2086: nmhs-42pym-gly-betainyl

2087: tolhs-24thiaz-gly-betainyl

2088: phhs-25oxaz-bala-psdapch

2089: bhs-24thiaz-gly-betathiome

2090: bhs-nme35pyr-gly-betabediox

2091: phhs-25thiaz-gly-betahph

2092: bhs-24thiaz-nmgly-betabpy

2093: ibhs-25methiaz-bala-betafu3

2094: phhs-24thioph-gly-betaoxope

2095: bhs-25methiaz-gly-busu2be

2096: dhim-24thiaz-ala-zdap

2097: bhs-ithiadiaz-bala-betainyl

2098: phhs-25methiaz-gly-betaomebendi

2099: bim-52thiaz-ala-betameph

2100: bim-35thioph-bala-zdap

2101: ibhs-25thiaz-bala-aspbzla

2102: ibhs-25thiaz-gly-busu2be

2103: tolhs-nme35pyr-gly-betaomebendi

2104: phhs-25methiaz-gly-betaet

2105: bhs-24thiaz-gly-betahdcph

01/283/02 / PB

107

2106: bim-42nmeim-gly-betah35dc

2107: bhs-me24thioph-gly-betapy

2108: phhs-25thiaz-gly-zdapee

2109: ibhs-nme35pyr-bala-betadbph

2110: tolhs-me25thiaz-gly-betaph

2111: bhs-me25thioph-bala-zdap

2112: impy-25oxaz-bala-betadmoph

2113: tolhs-25thiaz-bala-beta13bendi

2114: bhs-35fur-gly-psdap

2115: gua-25thioph-gly-betaph

2116: ibhs-25oxaz-bala-betaamibe

2117: 2py-24oxaz-leu-betadcph

2118: ibhs-ithiadiaz-gly-betahmofu

2119: bim-25thioph-ala-betapy

2120: ibhs-ithiadiaz-gly-betadcphee

2121: tolhs-me25oxaz-gly-betadcph

2122: tolhs-25methiaz-bala-betaheph

2123: ibhs-ithiadiaz-gly-betapy

2124: bhs-35py-ala-betapy

2125: bhs-35thioph-bala-psdap

2126: tolhs-me24thioph-bala-zdap

2127: phhs-25methiaz-gly-betahdcph

2128: bhs-25thiaz-bala-psdapee

2129: bhs-me25thioph-gly-beta34meoph

2130: phhs-oxadiaz-gly-betahdcph

2131: tolhs-25oxaz-gly-betaanaphth

2132: tolhs-25thiaz-bala-csdap

2133: 2py-ithiadiaz-leu-zdap

2134: ibhs-25oxaz-bala-betamethi

2135: bhs-25oxaz-bala-aspbzla

2136: phhs-nme35pyr-bala-betah35dc

01/283/02 / PB

108

2137: ibhs-24thioph-bala-betadcphch

2138: phhs-25methiaz-bala-betathiome

2139: 2py-52thiaz-ala-betapy

2140: ibhs-24thioph-gly-betabdimo

2141: dimethpym-25thiaz-gly-betameph

2142: bhs-25methiaz-gly-betaftrif

2143: tolhs-24thiaz-gly-betacph

2144: bhs-oxadiaz-bala-betapytb

2145: ibhs-oxadiaz-bala-betafbph

2146: ibhs-25thiaz-gly-betacbph

2147: phhs-24thioph-bala-betafluo

2148: phhs-me24thiaz-bala-beta34meoph

2149: tolhs-25thiaz-bala-betapyr

2150: phhs-25oxaz-bala-betadhbfu

2151: ibhs-25oxaz-bala-betadito

2152: bhs-24thioph-gly-betameph

2153: bhs-24thioph-bala-betacbph

2154: bim-25oxaz-gly-aspbzla

2155: impy-24thioph-gly-beta34meoph

2156: bhs-ithiadiaz-nmgly-betadmoph

2157: bim-35thioph-ala-betapy

2158: tolhs-25thiaz-bala-betadmph

2159: phhs-24thioph-bala-betaphethioa

2160: ibhs-25oxaz-bala-betafu2

2161: ibhs-nme35pyr-gly-betatrif

2162: 2py-24thiaz-gly-beta3quin

2163: 2 pmhs-25thiaz-gly-psdap

2164: bhs-25oxaz-gly-betatos

2165: tolhs-25methiaz-gly-beta3quin

2166: tolhs-24thioph-bala-betabthioph

2167: impy-25methiaz-bala-betamesu

01/283/02 / PB

109

2168

2169

2170

2171

2172

2173

2174

2175

2176

2177

2178

2179

2180

2181

2182

2183

2184

2185

2186

2187

2188

2189

2190

2191

2192

2193

2194

2195

2196

2197

2198 phhs-25oxaz-bala-psdapee tolhs-25thiaz-gly-betah35dc tolhs-24thioph-bala-betafu3 bhs-25methiaz-gly-betabdimo bhs-25fur-gly-betadcph phhs-ithiadiaz-bala-psdapaz tolhs-25-thiaz tolhs-oxadiaz-gly-betamesu bhs-25oxaz-bala-betabenfu ibhs-25methiaz-gly-betadcph bhs-24thioph-gly-betadito ibhs-24thiaz-bala-betaoxope tolhs-25methiaz-bala-betampy ibhs-aspala -me25oxaz-ala-betadcph ibhs-24thioph-gly-betapytb ibhs-ithiadiaz-bala-betainyl phhs-me25thiaz-gly-psdap phhs-oxadiaz-gly-betahb bhs-nme35pyr-ala-beta34dcph phhs-meth-24th 42nmeim-leu-betapy tolhs-24thiaz-gly-betaftrif ibhs-oxadiaz-gly-betahmph tolhs-ithiadiaz-bala-betahb bhs-35thioph-leu-betadcph bhs-25thiaz-bala-betadcph phhs-nme35pyr-gly-bet-hy-glys-gly-beth -gly-zdap phhs-25oxaz-bala-betahdcph bhs-oxadiaz-gly-betaibph

110

01/283/02 / PB

2199: 2py-me24thioph-leu-betaph

2200: tolhs-24thioph-gly-beta34dcph

2201: bhs-24thiaz-nmgly-betacph

2202: bhs-25oxaz-bala-betapyr

2203: bhs-25fur-leu-zdap

2204: impy-24oxaz-gly-betameph

2205: bhs-nme35pyr-gly-betahb

2206: tolhs-me24thiaz-bala-psdap 2207: ibhs-24thioph-gly-beta35dbph

2208: ibhs-24thioph-bala-betathio3

2209: bhs-24thiaz-bala-asppha

2210: bhs-24thioph-ala-betaanaphth

2211: ibhs-24thioph-bala-betahph

2212: tolhs-nme35pyr-bala-asppha

2213: bim-thiadiaz-leu-zdap

2214: 2py-35fur-bala-betapy

2215: phhs-24thioph-bala-betathioph

2216: phhs-ithiadiaz-bala-betadhbfu

2217: bhs-25thiaz-nmgly-betameph

2218: tolhs-ithiadiaz-gly-betahb

2219: 2py-ithiadiaz-gly-aspibua

2220: ibhs-25methiaz-bala-betamethioph

2221: bhs-oxadiaz-gly-betaet

2222: ibhs-nme35pyr-gly-betatos

2223: bhs-me25oxaz-gly-psdap

2224: bhs-25oxaz-bala-zdapee

2225: bhs-26py-gly-beta13bendi

2226: bhs-25fur-ala-betadcph

2227: ibhs-24thioph-gly-zdapch

2228: tolhs-25thiaz-bala-betadcphtb

2229: phhs-24thioph-bala-betadbph

01/283/02 / PB

111

2230: 2py-25oxaz-bala-aspbzla

2231: 2py-me25thioph-ala-beta34meoph

2232: ibhs-25thiaz-bala-beta34meoph

2233: ibhs-24thioph-bala-zdap

2234: phhs-24thiaz-bala-betathio3

2235: bhs-24thioph-bala-betatrif

2236: bhs-nme35pyr-bala-betadito

2237: phhs-nme35pyr-gly-betacbph

2238: bhs-24thioph-ala-betaoxaz

2239: impy-25thiaz-bala-betaphethioa

2240: 2py-25oxaz-bala-betafu3

2241: 2py-oxadiaz-ala-betapy

2242: ibhs-25methiaz-bala-betaet

2243: ibhs-ithiadiaz-gly-betatbuph

2244: phhs-24thioph-bala-betaol

2245: phhs-25thiaz-bala-beta23meoph

2246: phhs-25oxaz-bala-betabthioph

2247: bim-24im-bala-psdap

2248: bim-nme35pyr-gly-aspaba

2249: ibhs-25oxaz-bala-betaimide

2250: impy-24thiaz-gly-betaipr

2251: tolhs-25thiaz-bala-betapbiph

2252: phhs-25oxaz-bala-betadcph

2253: ibhs-ithiadiazgly-beta-4bph

2254: bhs-oxadiaz-gly-betah35dc

2255: phhs-oxadiaz-gly-betaipro

2256: bhs-25methiaz-nmgly-betathio3

2257: bim-35thioph-leu-zdap

2258: phhs-25oxaz-bala-betaipr

2259: ibhs-25methiaz-gly-zdapch

2260: bim-me25thiaz-bala-zdap

01/283/02 / PB

112

2261: phhs-nme35pyr-bala-betaamibe

2262: bhs-25thiaz-bala-aspaba

2263: bhs-24thiaz-gly-betathioph

2264: bhs-25oxaz-gly-betaphethio

2265: bhs-ithiadiaz-bala-betabediox

2266: phhs-nme35pyr-gly-betabnaphth

2267: bhs-nme35pyr-gly-betadtrif

2268: tolhs-25thiaz-bala-betainyl

2269: bhs-24thioph-gly-betabnaphth

2270: phhs-ithiadiaz-bala-betacbph 2271: bhs-25methiaz-bala-betatbuph 2272: bhs-25methiaz-ala-betathio3

2273: bim-25methiaz-gly-zdap

2274: tolhs-oxadiaz-gly-betafu2

2275: ibhs-24thiaz-bala-beta35dbph

2276: bhs-nme35pyr-gly-betadito

2277: bhs-oxadiaz-ala-ibsdap

2278: ibhs-25methiaz-gly-beta13bendi

2279: phhs-24thioph-bala-psdap

2280: ibhs-ithiadiaz-bala-betatos 2281: tolhs-25thiaz-gly-psdapch

2282: bhs-25methiaz-gly-betadhbfu

2283: phhs-24thiaz-gly-betaipro

2284: ibhs-oxadiaz-gly-zdap

2285: tolhs-nme35pyr-bala-betafphe

2286: bhs-25thiaz-ala-betaoxaz

2287: ibhs-24thioph-bala-betaet

2288: ibhs-24thiaz-bala-betafu3

2289: bhs-25oxaz-ala-ibsdap

2290: bhs-25methiaz-nmgly-betadito

2291: bim-24thioph-gly-betapbiph

113

01/283/02 / PB

2292: ibhs-25thiaz-bala-betadtrif

2293: tolhs-25methiaz-bala-betah35dc

2294: phhs-25methiaz-gly-betabdimo

2295: 2py-25oxaz-bala-aspibua

2296: ibhs-25thiaz-bala-betahmofu

2297: phhs-oxadiaz-gly-betathiome

2298: tolhs-oxadiaz-gly-betaomebendi

2299: tolhs-25thiaz-gly-betabmph

2300: ibhs-oxadiaz-bala-betahdcph

2301: 2py-me24thioph-leu-beta34meoph

2302: phhs-nme35pyr-gly-betabediox

2303: ibhs-nme35pyr-bala-betaibph

2304: 2py-me25thioph-bala-beta34meoph

2305: bhs-24thiaz-bala-betatos

2306: bhs-25thiaz-gly-betaol

2307: phhs-25oxaz-gly-betahb

2308: ibhs-oxadiaz-bala-betaphethioa

2309: tolhs-25thiaz-bala-betahmofu

2310: bhs-nme35pyr-ala-betahph

2311: ibhs-25oxaz-bala-betaibph

2312: tolhs-25oxaz-bala-betadmph

2313: 2py-me25oxaz-bala-zdap

2314: bhs-24thiaz-gly-betacph

2315: bim-oxadiaz-ala-zdap

2316: tolhs-25oxaz-bala-betamethi

2317: 2py-25thioph-ala-betadcph

2318: bhs-24thiaz-nmgly-ibsdap

2319: bim-42nmeim-gly-busu2be

2320: phhs-me24thioph-ala-betadcph

2321: bhs-24thiaz-nmgly-betadhbfu

2322: 2py-me25thiaz-bala-betapy

01/283/02 / PB

114

2323: bim-25thioph-gly-zdap

2324: tolhs-25oxaz-gly-betahmofu

2325: bhs-25methiaz-gly-betahmofu

2326: phhs-ithiadiaz-bala-suabu

2327: ibhs-25oxaz-gly-betamethi

2328: gua-26py-gly-betapy

2329: tolhs-25oxaz-gly-betapy

2330: bhs-me25oxaz-ala-betaph

2331: tolhs-nme35pyr-gly-betambiph

2332: bhs-24thioph-gly-betathiome

2333: phhs-25thiaz-gly-betaet

2334: tolhs-ithiadiaz-bala-betapyr

2335: phhs-24thioph-bala-zdapch

2336: tolhs-25methiaz-gly-zdap

2337: ibhs-24thiaz-gly-betacbph

2338: bhs-oxadiaz-bala-betahph

2339: tolhs-24thiaz-bala-betafu2

2340: ibhs-24thiaz-gly-psdap

2341: ibhs-ithiadiaz-bala-betabenfu

2342: bim-25oxaz-bala-psdap

2343: phhs-me25oxaz-leu-betapy

2344: ibhs-nme35pyr-bala-betabph

2345: bim-me25thioph-leu-betadcph

2346: bhs-ithiadiaz-bala-betabenfu

2347: phhs-25methiaz-bala-betabithioph

2348: bhs-nme35pyr-bala-psdapee

2349: ibhs-24thioph-bala-betabdimo

2350: ibhs-24thioph-gly-betaoxope

2351: bim-42pym-ala-zdap

2352: gua-26py-gly-suabu

2353: ibhs-25thiaz-bala-betaipro

01/283/02 / PB

115

2354: phhs-ithiadiaz-gly-betapytb

2355: 2 pmhs-25thiaz-gly-betameph

2356: bim-me24thioph-bala-psdap

2357: phhs-25thiaz-bala-betaphethio

2358: tolhs-oxadiaz-bala-betahbcph

2359: bhs-26py-gly-psdap

2360: bhs-24thiaz-gly-betaanaphth

2361: dhim-2thioph-gly-betameph

2362: 2py-me24thioph-leu-betadcph

2363: tolhs-24thiaz-bala-betabmph

2364: bhs-25oxaz-bala-beta35dbph

2365: tolhs-25methiaz-gly-betadhbfu

2366: bhs-24thioph-bala ~ betafluo

2367: tolhs-24thiaz-bala-betaol

2368: bim-24thioph-gly-betadbph

2369: phhs-24thioph-bala-betabph

2370: phhs-nme35pyr-bala-betacbph

2371: tolhs-ithiadiaz-bala-betadhbfu

2372: 2py-24oxaz-gly-betainyl

2373: ibhs-24thioph-gly-zdaptb

2374: 2py-25fur-leu-betadcph

2375: bhs-24thiaz-gly-betaimide

2376: ibhs-25methiaz-bala-beta13bendi

2377: bhs-24thiaz-bala-betapyr

2378: ibhs-24thiaz-bala-suabu

2379: tolhs-oxadiaz-gly-betambiph

2380: bhs-oxadiaz-nmgly-betathioph

2381: phhs-25methiaz-gly-betabediox

2382: ibhs-25thiaz-gly-betameph

2383: phhs-24thioph-bala-betaipro

2384: bhs-24chin-ala-betameph

01/283/02 / PB

2385: tolhs-25oxaz-gly-betaainyl 2386: 2py-25oxaz-bala-betapy 2387: tolhs-25methiaz-gly-betacph 2388: ibhs-25oxaz-bala-beta13bendi 2389: tolhs-25oxaz-gly-beta3quin 2390: ibhs-25oxaz -bala-rod

2391: tolhs-24thioph-bala-beta13bendi 2392: phhs-me24oxaz-bala-psdap 2393: bh-24thioph-bala-betatos 2394: tolhs-me25oxaz-ala-zdap 2395: bhs-me24oxaz-bala-zdap 2396: bhs-25thiaz -bala-betadbph 2397: phhs-ithiadiaz-gly-betainyl 2398: ibhs-ithiadiaz-gly-betapytb 2399: ibhs-24thiaz-gly-betah35dc 2400: tolhs-24thiaz-gly-betatbuph 2401: phhs-24thiaz-bala 24b: : bhs-53pyrazo-bala-betapy 2403: 2py-25oxaz-bala-betadcph 2404: phhs-me24thioph-leu-betapy 2405: tolhs-ithiadiaz-bala-betaanaphth 2406: ibhs-oxadiaz-bala-betaph 2407: phhs-meth 2507h gly-betafu2 2408: phhs-24thioph-gly-betadbph 2409: phhs-24thioph-bala-psdapee 2410: ibhs-24thiaz-bala-betacph 2411: bhs-me25thiaz-gly-betadcph 2412: phhs-oxadiaz-bala-betabpy 2413: ibhs-24thioph-gly-beta34dcph 2414: ibhs-25thiaz-gly-betapbiph 2415: tolhs-24thiaz-bala-beta34meoph

116

01/283/02 / PB

117

2416: tolhs-ithiadiaz-bala-betapbiph

2417: phhs-nme35pyr-bala-betadcph

2418: 2 pmhs-25methiaz-gly-betathiome

2419: bhs-me25thiaz-bala-psdap

2420: phhs-ithiadiaz-gly-betabenfu

2421: 2py-nme35pyr-leu-betadcph

2422: phhs-24thioph-bala-betadmph

2423: bhs-24thioph-bala-betahcbph

2424: 2py-25methiaz-bala-asppha

2425: 2py-26py-gly-betampy

2426: ibhs-nme35pyr-gly-zdapch

2427: tolhs-me24thiaz-ala-betapy

2428: tolhs-nme35pyr-gly-betapbiph

2429: phhs-ithiadiaz-gly-betapyee

2430: bhs-25oxaz-gly-beta34meoph

2431: 2py-35thioph-leu-betadcph

2432: ibhs-nme35pyr-gly-betabph

2433: bhs-ithiadiaz-gly-betaphethio

2434: tolhs-25thiaz-gly-zdapch

2435: 2py-24thioph-ala-zdap

2436: tolhs-ithiadiaz-gly-betahph

2437: phhs-25methiaz-bala-betaphethioa

2438: ibhs-25oxaz-gly-betah35dc

2439: gua-25thioph-gly-betaphethio

2440: bim-35fur-gly-psdap

2441: ibhs-ithiadiaz-bala-betaftrif

2442: tolhs-24thiaz-gly-beta34meoph

2443: bhs-25methiaz-bala-betacthioph

2444: bhs-nme35pyr-ala-betaoxaz

2445: 2py-me24thioph-gly-zdap

2446: 2py-25oxaz-gly-betambiph

01/283/02 / PB

118

2447: bhs-42nmeim-gly-psdap

2448: bhs-oxadiaz-gly-psdapee

2449: phhs-ithiadiaz-gly-betafph

2450: thazep-42pym-gly-beta13bendi

2451: phhs-25methiaz-bala-betabmph

2452: bhs-25methiaz-bala-betapbiph

2453: phhs-nme35pyr-gly-suabu

2454: ibhs-ithiadiaz-bala-betamethioph

2455: 2 pmhs-24thioph-gly-betafph

2456: tolhs-24thiaz-gly-betacbph

2457: phhs-25thiaz-bala-betathio3

2458: ibhs-oxadiaz-bala-betamethioph

2459: ibhs-25thiaz-gly-aspibua

2460: bhs-42nmeim-bala-betadcph

2461: phhs-25oxaz-bala-betaomebendi

2462: phhs-nme35pyr-gly-asppha

2463: ibhs-24thiaz-bala-betainyl

2464: bim-25oxaz-gly-aspibua

2465: bhs-ithiadiaz-ala-betafphe

2466: bhs-25oxaz-bala-betafphe

2467: ibhs-ithiadiaz-gly-betaibph

2468: gua-26py-gly-betabnaphth

2469: ibhs-25oxaz-gly-betathioph

2470: phhs-25methiaz-gly-betathiobe

2471: ibhs-24thiaz-gly-betadbph

2472: tolhs-ithiadiaz-gly-betabthioph

2473: bhs-oxadiaz-gly-busu2be

2474: phhs-24thioph-gly-betaphethioa

2475: bhs-24thiaz-ala-betameph

2476: tolhs-25thiaz-bala-betaol

2477: bhs-ithiadiaz-bala-betahmofu

01/283 / 02PB 119

2478: phhs-ithiadiaz-bala-betaph

2479: bhs-35fur-gly-betapy

2480: ibhs-24thioph-bala-betapych

2481: phhs-25oxaz-gly-beta13bendi

2482: bhs-25thiaz-ala-betadito

2483: bhs-ithiadiaz-bala-psdap

2484: bim-24thioph-bala-betaipro

2485: phhs-24thioph-bala-beta34dcph

2486: tolhs-me24thioph-leu-betapy

2487: phhs-25methiaz-gly-betahmph

2488: tolhs-oxadiaz-gly-betatbuph

2489: bhs-me24thioph-bala-zdap

2490: phhs-24thioph-gly-betahmo

2491: bhs-nme35pyr-gly-betabmph

2492: bim-24thioph-gly-zdap

2493: ibhs-25thiaz-bala-betahc

2494: ibhs-ithiadiaz-bala-zdaptb

2495: bhs-24thiaz-gly-betadcphee

2496: ibhs-24thioph-bala-betacbph

2497: ibhs-ithiadiaz-bala-betaph

2498: ibhs-25methiaz-gly-betahdcph

2499: phhs-24thiaz-bala-betafbph

2500: phhs-25oxaz-gly-betadhbfu

2501: bhs-42oxaz-leu-zdap

2502: phhs-ithiadiaz-gly-betaomebendi

2503: phhs-24thiaz-bala-beta4bph

2504: bhs-24thioph-bala-betaipro

2505: phhs-oxadiaz-bala-betahc

2506: tolhs-25oxaz-bala-betadito

2507: bhs-nme35pyr-gly-betapbiph

2508: bhs-25methiaz-gly-betameph

120

01/283 / 02PB

2509: ibhs-25oxaz-bala-beta4bph 2510: ibhs-ithiadiaz-bala-betadtrif 2511: bhs-ithiadiaz-gly-betabph 2512: bhs-25oxaz-bala-beta 13bendi 2513: tolhs-25oxaz-bala-betafluo-2514: 25thiaz-bala-aspibua 2515: ibhs-24thiaz-gly-betapytb 2516: tolhs-me25oxaz-leu-psdap 2517: phhs-25methiaz-bala-betahph 2518: bhs-24thioph-ala-betadhbfii 2519: bim-24thiaz-phg 2520: bhs-me25thiaz-bala-betapy 2521: 2py-35fur-bala-psdap 2522: phhs-me25thioph-ala-betadcph 2523: bhs-me25thiaz-gly-betaph 2524: phhs-25thiaz-gly-asppha 2525: phhs-25methiaz -gly-betadcphtb 2526: ibhs-nme35pyr-bala-betapbiph 2527: phhs-ithiadiaz-gly-betadtrif 2528: bhs-24thiaz-gly-betabdimo 2529: bhs-25methiaz-ala-betabnaphth 2530: 2py-me25thiaz : ibhs-24thiaz-gly-betaipr 2532: dhim-25thioph-gly-betahcbph 2533: tolhs-me24thiaz-leu-beta34imeoph 2534: bhs-25thiaz-bala-betaipro 2535: bim-me24thiaz-ala-psdap 2536: gua-25thioph- gly-betapbiph 2537: 2 pmhs-24thioph-gly-betaph 2538: bhs-24thioph-bala-betaibph 2539: tolhs-24thiop h-bala-betabnaphth

01/283 / 02PB

121

2540: bhs-nme35pyr-bala-betampy

2541: bim-ithiadiaz-bala-aspbzla

2542: ur-25thioph-gly-zdap

2543: bhs-24thioph-gly-betatos

2544: bhs-nme35pyr-gly-aspaba

2545: tolhs-ithiadiaz-gly-zdapch

2546: ibhs-24thioph-gly-betapyr

2547: bhs-ithiadiaz-bala-betaibph

2548: bhs-25methiaz-bala-betathiobe

2549: ibhs-25thiaz-bala-beta13bendi

2550: bhs-24thioph-ala-betainyl

2551: 2 pmhs-25oxaz-gly-betadito

2552: tolhs-oxadiaz-bala-ibsdap

2553: bim-me24oxaz-leu-betadcph

2554: phhs-25thiaz-bala-betainyl

2555: phhs-me24oxaz-bala-betaph

2556: bhs-23thioph-gly-betapy

2557: tolhs-25methiaz-bala-betafbph

2558: bhs-oxadiaz-bala-betabenfu

2559: phhs-24thiaz-gly-betadcph

2560: phhs-25oxaz-gly-betaomebendi

2561: tolhs-nme35pyr-gly-betadcph

2562: ibhs-24thioph-bala-zdapch

2563: tolhs-nme35pyr-gly-betah35dc

2564: ibhs-25thiaz-gly-betabthioph

2565: tolhs-24thioph-gly-betabediox

2566: bhs-25thiaz-gly-betathiobe

2567: phhs-oxadiaz-bala-beta3quin

2568: ibhs-25thiaz-gly-betaph

2569: phhs-25thiaz-gly-betampy

2570: ibhs-nme35pyr-gly-betabdimo

01/283 / 02PB

122

2571: 2py-25methiaz-hphe-psdap

2572: phhs-ithiadiaz-gly-betahni

2573: bhs-nme35pyr-ala-betafphe

2574: 2py-52thiaz-ala-betameph

2575: gua-24thiaz-gly-betafph

2576: ibhs-24thioph-bala-beta4bph

2577: bhs-24thiaz-bala-betaheph

2578: ibhs-25methiaz-gly-betaph

2579: phhs-nme35pyr-gly-betahcbph

2580: phhs-ithiadiaz-bala-betah35dc

2581: bhs-oxadiaz-bala-beta23meoph

2582: bim-25thiaz-gly-betaibph

2583: tolhs-25methiaz-bala-beta34dcph

2584: tolhs-24thioph-gly-zdapee

2585: tolhs-oxadiaz-gly-betahmo

2586: 4 pmhs-24oxaz-gly-betameph

2587: ibhs-ithiadiaz-bala-betafbph

2588: bhs-oxadiaz-bala-betaftrif

2589: gua-24oxaz-gly-betafu2

2590: tolhs-me24thiaz-gly-betadcph

2591: bhs-25thiaz-bala-betathiome

2592: impy-25oxaz-gly-betameph

2593: ibhs-25thiaz-bala-betafbph

2594: tolhs-24thiaz-bala-betaipro

2595: tolhs-25oxaz-bala-betapytb

2596: bim-me24thioph-leu-betapy

2597: tolhs-24thioph-gly-betaphethio

2598: 2py-25thioph-gly-psdap

2599: bhs-25thiaz-gly-betahmo

2600: tolhs-oxadiaz-bala-aspaba

2601: bhs-oxadiaz-leu-zdap

01/283/02 P B

123

2602: hs-24thiaz-bala-betapy

2603: bhs-25thiaz-gly-betaoxope

2604: bhs-24thioph-bala-betathioph

2605: tolhs-ithiadiaz-bala-betabpy

2606: phhs-ithiadiaz-gly-betamethi

2607: phhs-24thiaz-gly-betatrif

2608: ibhs-nme35pyr-gly-betahmph

2609: phhs-25oxaz-bala-betacbph

2610: tolhs-25thiaz-gly-asppha

2611: bhs-25thiaz-bala-betahc

2612: tolhs-25thiaz-gly-betaph

2613: bhs-ithiadiaz-gly-zdapee

2614: bhs-25oxaz-bala-betamesu

2615: bhs-nme35pyr-gly-betahc

2616: tolhs-me25thiaz-gly-betapy

2617: bhs-oxadiaz-bala-betafph

2618: bim-nme35pyr-leu-betadcph

2619: tolhs-nme35pyr-bala-betamesu

2620: dhim-25thiaz-gly-betameph

2621: tolhs-me25thioph-ala-betapy

2622: ibhs-oxadiaz-bala-betaamibe

2623: impy-24thiaz-gly-betabthioph

2624: ibhs-25oxaz-bala-betaph

2625: bhs-25methiaz-gly-betapych

2626: bhs-25methiaz-gly-betambiph

2627: tolhs-25oxaz-gly-betadtrif

2628: bhs-25methiaz-nmgly-betadmph

2629: bhs-25thiaz-ala-betabpy

2630: ibhs-25oxaz-gly-betacthioph

2631: 2py-24thioph-gly-betacthioph

2632: bhs-24thioph-gly-betadcphee

01/283 / 02PB

124

2633: ibhs-25oxaz-gly-betadbph

2634: phhs-24thiaz-gly-betapym

2635: tolhs-nme35pyr-bala-betathiome

2636: bhs-ithiadiaz-ala-betadmph

2637: bhs-25thiaz-bala-betahmo

2638: bhs-25methiaz-nmgly-betahph

2639: tolhs-nme35pyr-gly-betameph

2640: ibhs-25methiaz-gly-betaomebendi

2641: bim-25oxaz-bala-beta4bph

2642: 2py-24thiaz-gly-betainyl

2643: bhs-ithiadiaz-bala-betaipr

2644: bhs-25thiaz-bala-betahdbph

2645: ibhs-25oxaz-gly-betahcbph

2646: tolhs-24thiaz-bala-betaibph

2647: 2py-25fur-gly-psdap

2648: phhs-25thiaz-bala-betaph

2649: bhs-24thiaz-gly-betapy

2650: ibhs-nme35pyr-bala-betabthioph

2651: tolhs-ithiadiaz-gly-betainyl

2652: dhpyrr-42nmeim-gly-zdap

2653: bhs-nme35pyr-gly-csdap

2654: gua-25thiaz-gly-betatos

2655: bhs-24thioph-gly-betatbuph

2656: ibhs-25oxaz-bala-betatbuph

2657: bhs-25thiaz-bala-betabenfu

2658: ibhs-nme35pyr-gly-betapy

2659: 2py-26py-gly-ibsdap

2660: 2py-24thiaz-bala-aspibua

2661: bhs-oxadiaz-gly-betabediox

2662: phhs-nme35pyr-bala-betafu2

2663: bhs-thiadiaz-ala-betadcph

01/283 / 02PB

125

2664: bhs-oxadiaz-bala-betaheph

2665: bhs-25thiaz-gly-beta34meoph

2666: bhs-25methiaz-bala-betadmph

2667: bhs-25thiaz-bala-betaftrif

2668: ibhs-24oxaz-gly-zdap

2669: tolhs-ithiadiaz-bala-betah35dc

2670: 2py-24thiaz-bala-betafluo

2671: agua-24thiaz-gly-betainyl

2672: bim-25methiaz-bala-aspaba

2673: bhs-25thiaz-gly-betahmph

2674: phhs-25thiaz-bala-betaet

2675: bhs-25thiaz “bala-psdapch

2676: phhs-oxadiaz-gly-betadcph

2677: 2py-42nmeim-nmala-betapy

2678: ibhs-26py-gly-betainyl

2679: phhs-25methiaz-gly-ibsdap

2680: bim-42pym-ala-psdap

2681: phhs-24thiaz-bala-betahph

2682: tolhs-24thioph-gly-betabdimo

2683: ibhs-25oxaz-bala-betatrif

2684: bhs-nme35pyr-ala-zdap

2685: bhs-25fur-bala-betapy

2686: phhs-24thioph-gly-betabnaphth

2687: tolhs-nme35pyr-bala-betathioph

2688: phhs-25methiaz-bala-betaamibe

2689: tolhs-24thiaz-bala-betafbph

2690: ibhs-oxadiaz-gly-psdaptb

2691: tolhs-nme35pyr-gly-suabu

2692: tolhs-25methiaz-gly-betabnaphth

2693: bhs-25oxaz-mngly-betabnaphth

2694: ibhs-25thiaz-bala-betapytb

01/283 / 02PB

126

2695: tolhs-nme35pyr-bala-psdapee

2696: 2py-24thioph-gly-betadcph

2697: sabhs-25thiaz-ala-betameph

2698: bhs-25methiaz-gly-betathio3

2699: ibhs-25methiaz-gly-psdaptb

2700: bhs-nme35pyr-gly-betapym

2701: ibhs-25thiaz-gly-ibsdap

2702: impy-25methiaz-bala-betaftrif

2703: tolhs-25methiaz-gly-betafluo

2704: ibhs-25oxaz-bala-betaoxope

2705: gua-26py-gly-betafbph

2706: bhs-nme35pyr-bala-betahb

2707: ibhs-nme35pyr-bala-betapyee

2708: bhs-24oxaz-bala-psdap

2709: bhs-25oxaz-bala-betahdbph

2710: phhs-25oxaz-bala-zdap

2711: phhs-25methiaz-gly-betah35dc

2712: ibhs-25thiaz-bala-betacph

2713: tolhs-25thiaz-gly-betaamibe

2714: bhs-ithiadiaz-bala-betahmo

2715: tolhs-24thiaz-gly-suabu

2716: phhs-nme35pyr-gly-betaol

2717: phhs-24thiaz-bala-betapbiph

2718: bhs-oxadiaz-nmgly-betadito

2719: tolhs-ithiadiaz-gly-betaanaphth

2720: tolhs-25thiaz-gly-busu2be

2721: bim-24im-ala-betadcph

2722: ibhs-25thiaz-gly-betahmofu

2723: tolhs-oxadiaz-bala-betaomebendi

2724: bhs-ithiadiaz-gly-betadtrif

2725: ibhs-25methiaz-gly-betathioph

01/283 / 02PB

127

2726: phhs-25methiaz-bala-betahdbph

2727: bhs-nme35pyr-bala-betaol

2728: gua-26py-gly-betahc

2729: ibhs-25oxaz-bala-beta34meoph

2730: bim-25methiaz-bala-betahcbph

2731: phhs-nme35pyr-bala-betafph

2732: tolhs-25oxaz-bala-betaet

2733: 2py-nme35pyr-gly-betadcph

2734: tolhs-oxadiaz-gly-betaol

2735: bhs-24im-ala-zdap

2736: 2py-35thioph-gly-betadcph

2737: tolhs-25methiaz-gly-psdapee

2738: impy-25methiaz-bala-psdap

2739: ibhs-25methiaz-bala-betabediox

2740: tolhs-nme35pyr-bala-betaphethioa

2741: tolhs-ithiadiaz-gly-betahbcph

2742: thazep-24thioph-bala-zdap

2743: dhim-25py-gly-betameph

2744: 2py-25fur-gly-betapy

2745: impy-42nmeim-gly-betabmph

2746: tolhs-24thioph-gly-betacbph

2747: phhs-oxadiaz-bala-betaftrif

2748: tolhs-25thiaz-bala-betacph

2749: phhs-24thiaz-bala-betadito

2750: bhs-25fur-ala-betapy

2751: ibhs-25oxaz-gly-betahb

2752: tolhs-24thiaz-bala-zdapee

2753: bhs-25oxaz-gly-betahmo

2754: gua-24thiaz-gly-betamethioph

2755: nmhs-24thiaz-gly-betapy

2756: phhs-25thiaz-gly-betafph

01/283 / 02PB

128

2757: tolhs-25oxaz-gly-betadmoph 2758: phhs-oxadiaz-bala-betaet 2759: bhs-24thiaz-gly-psdapee 2760: ibhs-24thiaz-bala-betabediox 2761: gua-24thiaz-gly-betafu3 2762: tolhs-nme35pyr -bala-betaphethio 2763: ibhs-24thioph-gly-psdap 2764: tolhs-me24oxaz-leu-beta34meoph 2765: 2py-24thioph-bala-aspaba 2766: bim-me24oxaz-leu-psdap 2767: bhs-nme35pyr-bala-betamesu : bhs-thiadiaz-gly-zdap 2769: 2py-oxadiaz-ala-zdap 2770: bim-25methiaz-gly-betapbiph 2771: ibhs-24thioph-gly-betadcphee 2772: tolhs-nme35pyr-bala-betahdcph 2773: bhs-me24-th24 gly-betadcph 2774: phhs-25thiaz-bala-zdapch 2775: bhs-25thiaz-gly-betapych 2776: bhs-ithiadiaz-bala-betahdbph TPT. impy-24thiaz-nmgly-psdap 2778: bim-25oxaz-bala-beta13bendi 2779: bim-oxadiaz-bala-betapy 2780: tolhs-24thiaz-bala-betahdcph 2781: 2py-nme35pyr-ala-psdap 2782: ibhs-25thiaz-glyth -betadtrif 2783: phhs-25thiaz-gly-betahbcph 2784: ibhs-oxadiaz-bala-zdapch 2785: dhim-26py-hphe-zdap 2786: phhs-nme35pyr-gly-betahbcph 2787: bhs-25thiaz-bala-betafluo

01/283 / 02PB

129

2788: ibhs-oxadiaz-gly-beta3quin

2789: 2py-35fur-bala-betadcph

2790: 2py-me25oxaz-gly-betadcph

2791: bhs-24thiaz-gly-betaipr

2792: bhs-25methiaz-bala-betabediox

2793: ibhs-ithiadiaz-gly-betaph

2794: phhs-25thiaz-bala-aspibua

2795: tolhs-oxadiaz-bala-betabdimo

2796: 2py-me24thiaz-ala-betapy

2797: impy-25methiaz-ala-betapy

2798: phhs-nme35pyr-bala-betabnaphth

2799: bim-me25oxaz-leu-betapy

2800: gua-me24thiaz-gly-betapy

2801: 2py-24im-gly-betapy

2802: bhs-25thiaz-bala-betapbiph

2803: bhs-24thioph-bala-ibsdap

2804: 2py-35thioph-leu-betapy

2805: bhs-25thiaz-ala-beta3quin

2806: ibhs-24thioph-bala-csdap

2807: bhs-53pyrazo-bala-zdap

2808: bhs-42nmeim-gly-betapy

2809: phhs-25oxaz-gly-betathioph 2810: ibhs-25methiaz-gly-betabpy 2811: ibhs-24thiaz-bala-betapyee 2812: bhs-25thiaz-nmgly-betaipro

2813: bhs-25methiaz-bala-betampy

2814: bhs-24thioph-bala-betamesu

2815: bim-me24oxaz-bala-zdap

2816: bhs-25methiaz-gly-betaph

2817: bim-25thiaz-gly-zdap

2818: bhs-nme35pyr-gly-betatbuph

01/283 / 02PB

130

2819: bhs-25oxaz-ala-betadhbfu

2820: ibhs-ithiadiaz-bala-betaphethioa

2821: bhs-oxadiaz-gly-betathiome

2822: phhs-24thioph-bala-betabediox

2823: bhs-25thiaz-bala-betathioph

2824: phhs-oxadiaz-bala-betaipr

2825: bim-me25thioph-gly-betadcph

2826: bhs-25oxaz-gly-betameph

2827: bhs-oxadiaz-gly-beta13bendi

2828: ibhs-oxadiaz-gly-zdapee

2829: 2py-me24thioph-bala-psdap

2830: bhs-25thiaz-bala-betacbph

2831: 2py-me25oxaz-leu-betadcph

2832: tolhs-25thiaz-bala-betahcbph

2833: ibhs-25oxaz-bala-betabdimo

2834: 2py-25thioph-ala-betainyl

2835: bhs-oxadiaz-bala-betathioph

2836: bhs-25methiaz-gly-betaipro

2837: bhs-24thioph-ala-betapy

2838: ibhs-25thiaz-gly-betafluo

2839: 2py-24oxaz-gly-zdap

2840: phhs-oxadiaz-bala-betadcphee

2841: 2py-24thiaz-ala-betadcph

2842: ibhs-24thiaz-gly-betaheph

2843: bhs-me25oxaz-ala-betapy

2844: ibhs-nme35pyr-bala-betaomebendi

2845: bhs-thiadiaz-gly-betapy

2846: bhs-25thiaz-gly-betadhbfu

2847: dhim-24oxaz-gly-betapy

2848: gua-24thiaz-gly-betafluo

2849: bhs-thiadiaz-bala-zdap

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2850: ibhs-25oxaz-gly-betahni

2851: tolhs-25thiaz-bala-betahc

2852: bhs-nme35pyr-ala-ibsdap

2853: bhs-oxadiaz-gly-betabdimo

2854: phhs-me24thiaz-leu-betaph

2855: tolhs-25thiaz-bala-betathioph

2856: bhs-25oxaz-bala-betatrif

2857: ibhs-24thiaz-gly-betamesu

2858: bim-25thiaz-ala-betainyl

2859: bhs-me25thiaz-leu-zdap

2860: tolhs-me24thiaz-bala-betadcph

2861: ibhs-25oxaz-gly-betacph

2862: bim-26py-ala-zdap

2863: bhs-oxadiaz-nmgly-betacph

2864: ibhs-25methiaz-gly-beta3quin

2865: 2py-me25thiaz-gly-zdap

2866: 2 pmhs-24thioph-bala-betahph

2867: impy-25methiaz-bala-betafu3

2868: phhs-nme35pyr-gly-betamesu

2869: ibhs-oxadiaz-gly-betaphethioa

2870: tolhs-24thioph-bala-betathioph

2871: ibhs-25oxaz-gly-psdaptb

2872: bim-25methiaz-gly-betapy

2873: 2py-25oxaz-ala-zdap

2874: phhs-24thiaz-gly-betadtrif

2875: bhs-oxadiaz-bala-betacthioph

2876: 2py-nme35pyr-gly-aspbzla

2877: ibhs-25oxaz-gly-betafu2

2878: ibhs-24thioph-bala-betahb

2879: bim-me25oxaz-bala-zdap

2880: bim-42nmeim-bala-beta34meoph

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132

2881: bim-me24thiaz-gly-betapy

2882: phhs-25methiaz-gly-csdap

2883: bhs-ithiadiaz-gly-betapym

2884: phhs-24thioph-bala-betacbph

2885: bhs-25oxaz-gly-betafu3

2886: 2py-24im-leu-psdap

2887: bhs-me25thioph-ala-betadcph

2888: tolhs-25thiaz-gly-betadcphee

2889: bhs-25oxaz-bala-ibsdap

2890: 2py-me24thiaz-bala-zdap

2891: bhs-me25thioph-gly-betaph

2892: phhs-nme35pyr-bala-betaet

2893: bim-24thiaz-gly-betaanaphth

2894: bhs-24thiaz-ala-betathioph

2895: bhs-53pyrazo-leu-zdap

2896: 2py-42nmeim-bala-betahmph

2897: 2py-me25oxaz-gly-betapy

2898: tolhs-24thioph-gly-betamethi

2899: bhs-24thioph-bala-betadbph

2900: ibhs-25thiaz-gly-beta35dbph

2901: phhs-24thioph-bala-aspbzla

2902: tolhs-24thioph-bala-beta35dbph

2903: bhs-nme35pyr-bala-betaipr

2904: bim-me24thiaz-bala-beta34meoph

2905: ibhs-24thioph-gly-betamesu

2906: 2py-me25thioph-gly-betaph

2907: dhim-25thioph-ala-psdap

2908: impy-24thiaz-ala-betapy

2909: tolhs-nme35pyr-gly-betahbcph

2910: tolhs-oxadiaz-gly-betacthioph

2911: bhs-nme35pyr-gly-betahph

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133

2912: tolhs-25oxaz-gly-betaipro

2913: phhs-25oxaz-bala-betahni

2914: ibhs-25methiaz-bala-csdap

2915: 2py-25thiaz-ala-psdap

2916: tolhs-me24oxaz-gly-psdap

2917: ibhs-ithiadiaz-gly-betaftrif

2918: phhs-nme35pyr-gly-betadtrif

2919: 2 pmhs-25methiaz-bala-beta 13bendi

2920: bhs-oxadiaz-nmgly-beta34dcph

2921: bim-25thiaz-bala-betaipro

2922: phhs-oxadiaz-gly-betabthioph

2923: bhs-24thioph-gly-betahmo

2924: phhs-24thioph-bala-betahmofu

2925: tolhs-me24thiaz-leu-betaph

2926: tolhs-25thiaz-bala-betahbcph

2927: ibhs-ithiadiaz-gly-beta13bendi

2928: tolhs-ithiadiaz-gly-suabu

2929: bim-26py-ala-betapy

2930: ibhs-24thioph-bala-betacthioph

2931: ibhs-25thiaz-gly-betaet

2932: phhs-nme35pyr-gly-betaoxope

2933: bim-35fur-gly-betapy

2934: phhs-oxadiaz-gly-betafu2

2935: bhs-52thiaz-ala-betadcph

2936: tolhs-25methiaz-bala-betahmph

2937: ibhs-25thiaz-bala-betaftrif

2938: tolhs-oxadiaz-bala-zdap

2939: bim-me25thioph-ala-beta34meoph

2940: gua-42pym-gly-beta35dbph

2941: gua-26py-gly-betabpy

2942: 4 pmhs-25thiaz-gly-zdap

01/283 / 02PB 134

2943: tolhs-oxadiaz-gly-betaphethioa

2944: tolhs-nme35pyr-gly-betatbuph

2945: gua-26py-gly-betahbcph

2946: bhs-25thiaz-bala-betacthioph

2947: ibhs-24thioph-bala-suabu

2948: ibhs-24thiaz-gly-betacph

2949: ibhs-nme35pyr-gly-betaftrif

2950: 2py-me25thiaz-gly-betadcph

2951: 2py-24oxaz-ala-zdap

2952: agua-24thiaz-gly-betadcph

2953: impy-42nmeim-bala-betahb

2954: bhs-25oxaz-bala-betabdimo

2955: phhs-nme35pyr-bala-zdap

2956: bhs-me24thiaz-leu-zdap

2957: tolhs-24thiaz-bala-beta23meoph

2958: bhs-triaz-gly-betameph

2959: bhs-ithiadiaz-gly-betathio3

2960: ibhs-nme35pyr-bala-betafph

2961: gua-24thiaz-gly-betahni

2962: bhs-25thiaz-nmgly-betacthioph

2963: tolhs-25oxaz-bala-betadcphch

2964: phhs-25thiaz-bala-betafu3

2965: tolhs-ithiadiaz-bala-zdaptb

2966: ibhs-ithiadiaz-gly-betaipro

2967: bhs-25oxaz-ala-betaoxaz

2968: phhs-ithiadiaz-gly-betaipr

2969: bhs-nme35pyr-bala-betabenfu

2970: 2py-52thiaz-ala-psdap

2971: bhs-24thioph-gly-betabpy

2972: dhthi-25methiaz-bala-betadcph

2973: ibhs-24thioph-gly-betaomebendi

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135

2974: tolhs-nme35pyr-gly-betadcphch

2975: bhs-25thiaz-bala-betaanaphth

2976: bhs-25methiaz-ala-betaoxaz

2977: tolhs-25methiaz-bala-betadmph

2978: 2py-42nmeim-gly-betadcph

2979: bhs-35thioph-gly-betadcph

2980: phhs-nme35pyr-bala-betahmofu

2981: ibhs-25methiaz-gly-betahmph

2982: tolhs-ithiadiaz-gly-betapym

2983: bhs-ithiadiaz-gly-betadcphee

2984: bim-53pyrazo-bala-betadcph

2985: tolhs-25oxaz-bala-betabph

2986: ibhs-25oxaz-gly-betahph

2987: tolhs-25oxaz-gly-betampy

2988: ibhs-oxadiaz-bala-zdaptb

2989: bhs-oxadiaz-bala-betafbph

2990: tolhs-25oxaz-gly-betaipr

2991: bim-me24thioph-bala-beta34meoph

2992: bhs-42pym-gly-betadcph

2993: phhs-25methiaz-bala-betadtrif

2994: 2py-25oxaz-gly-betaipr

2995: phhs-oxadiaz-bala-betacbph

2996: ibhs-24thioph-gly-betaoxaz

2997: tolhs-ithiadiaz-gly-betaftrif

2998: bhs-nme35pyr-nmgly-betaoxaz

2999: bhs-25thiaz-ala-betabnapbth

3000: phhs-24thioph-gly-betacbph

3001: bhs-me25thioph-leu-betapy

3002: bhs-me24thiaz-ala-betadcph

3003: ibhs-25thiaz-bala-betaol

3004: ibhs-25methiaz-gly-betabediox

01/283 / 02PB 136

3005: phhs-25thiaz-gly-betaipr

3006: bim-24oxaz-bala-zdap

3007: bhs-25oxaz-bala-zdapch

3008: 3 pmhs-25thiaz-bala-betapy

3009: tolhs-25methiaz-bala-betafluo

3010: bhs-ithiadiaz-gly-betapbiph

3011: phhs-24thiaz-gly-beta23meoph

3012: bhs-nme35pyr-gly-betadhbfu

3013: ibhs-25oxaz-bala-aspaba

3014: thpym-24thiaz-gly-betadcph

3015: bhs-oxadiaz-gly-betafbph

3016: 2py-25thiaz-leu-psdap

3017: 2py-53pyrazo-ala-psdap

3018: ibhs-nme35pyr-bala-beta23meoph

3019: tolhs-24thioph-gly-betahni

3020: ibhs-24thioph-gly-betamethioph

3021: bhs-25methiaz-bala-betahc

3022: phhs-oxadiaz-bala-betamethioph

3023: ibhs-25methiaz-bala-aspaba

3024: bim-24thioph-gly-betaomebendi

3025: tolhs-ithiadiaz-gly-betapytb

3026: bim-25methiaz-gly-betatrif

3027: 2py-me25thiaz-gly-betaph

3028: phhs-25oxaz-bala-betabpy

3029: phhs-nme35pyr-gly-betahph

3030: tolhs-ithiadiaz-gly-betabmph

3031: tolhs-25methiaz-gly-betahni

3032: phhs-25methiaz-bala-betaomebendi

3033: tolhs-oxadiaz-gly-betamethi

3034: ibhs-24thiaz-bala-csdap

3035: ibhs-ithiadiaz-gly-betaomebendi

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137

3036: tolhs-oxadiaz-bala-betamesu 3037: bhs-24thioph-gly-psdapch 3038: phhs-24thioph-gly-zdap 3039: 2py-25oxaz-bala-psdap 3040: bhs-me24thiaz-ala-betapy 3041: tolhs-24thioph -bala-beta34dcph 3042: 2py-25thioph-leu-betadcph 3043: bhs-25methiaz-gly-betafluo 3044: tolhs-25oxaz-gly-betahmph 3045: tolhs-nme35pyr-bala-betacbph 3046: ibhs-25thiaz-30-bala-betala : sabhs-25methiaz-gly-psdap 3048: ibhs-ithiadiaz-gly-zdapee 3049: ibhs-nme35pyr-gly-betafph 3050: bim-25thioph-bala-betadcph 3051: phhs-25oxaz-bala-betahph 3052: phhs-nme35 bala-aspaba 3053: ibhs-24thioph-gly-beta4bph 3054: bhs-25thiaz-gly-betatrif 3055: bhs-25thiaz-bala-betathio3 3056: tolhs-ithiadiaz-gly-betathio3 3057: tolhs-ithiadiaz-bala-zdap 3058: bim-24thiaz-bala-betatos 3059: tolhs-25oxaz-gly-suabu 3060: bhs-24thioph-bala-betapbiph 3061: ibhs-oxadiaz-bala-betabnaphth 3062: bim-42nmeim-gly-zdap 3063: phhs-me25thiaz-leu-le25thiaz -betapy 3064: bhs-25methiaz-gly-betamesu 3065: bhs-me25thiaz-gly-psdap 3066: tolhs-me25oxaz-bala-zdap

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138

3067: bim-53pyrazo-ala-betapy

3068: phhs-ithiadiaz-bala-beta34dcph

3069: ibhs-25thiaz-gly-betapyee

3070: tolhs-25thiaz-bala-betaoxope

3071: ibhs-25methiaz-gly-betampy

3072: tolhs-24thiaz-gly-betaoxope

3073: bhs-oxadiaz-gly-beta34meoph

3074: tolhs-ithiadiaz-bala-betaoxaz

3075: phhs-24thioph-gly-betadcphch

3076: 2py-me24thiaz-bala-psdap

3077: bhs-25thiaz-ala-betainyl

3078: phhs-25thiaz-gly-betahdcph

3079: phhs-25thiaz-gly-betah35dc

3080: tolhs-25methiaz-gly-betathio3

3081: 2py-me24thioph-gly-betaph

3082: bhs-24thioph-bala-betaoxope

3083: bhs-24thiaz-bala-aspbzla

3084: phhs-25thiaz-bala-betamethioph

3085: tolhs-25thiaz-bala-betadcphee

3086: bhs-24thioph-leu-betadcph

3087: ibhs-24thioph-gly-ibsdap

3088: phhs-nme35pyr-gly-betaibph

3089: phhs-25thiaz-bala-betahdbph

3090: bgua-24thiaz-gly-psdap

3091: bhs-25oxaz-gly-betadcph

3092: phhs-nme35pyr-bala-betaol

3093: tolhs-ithiadiaz-bala-betaibph

3094: phhs-25thiaz-bala-betacph

3095: ibhs-nme35pyr-bala-betabediox

3096: tolhs-ithiadiaz-gly-betapych

3097: bhs-nme35pyr-gly-psdap

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139

3098: phhs-25thiaz-gly-betahb

3099: phhs-24thiaz-gly-betafu2

3100: tolhs-ithiadiaz-bala-betadcph

3101: ibhs-25oxaz-gly-betabph

3102: gua-24oxaz-gly-betapym

3103: tolhs-25thiaz-bala-betabediox

3104: bim-thiadiaz-bala-psdap

3105: tolhs-24thiaz-bala-betamethi

3106: bhs-24thioph-gly-betaol

3107: bim-25thioph-bala-psdap

3108: tolhs-25oxaz-gly-aspbzla

3109: tolhs-24thioph-bala-betaamibe

3110: bhs-me24thiaz-gly-betapy

3111: ibhs-oxadiaz-bala-betadmoph

3112: tolhs-25thiaz-bala-betabmph

3113: phhs-25thiaz-bala-betabmph

3114: phhs-25oxaz-bala-beta34meoph

3115: phhs-25methiaz-gly-asppha

3116: bhs-25methiaz-bala-betatrif

3117: bim-me24thiaz-leu-psdap

3118: ibhs-25thiaz-gly-betabdimo

3119: gua-25oxaz-gly-zdap

3120: bhs-25oxaz-gly-betahmph

3121: bim-42pym-gly-betapy

3122: ibhs-25thiaz-gly-psdaptb

3123: bhs-25oxaz-bala-beta4bph

3124: bhs-ithiadiaz-gly-betahcbph

3125: ibhs-25thiaz-bala-zdapch

3126: ibhs-nme35pyr-bala-busu2be

3127: bhs-24oxaz-ala-betadcph

3128: bhs-25methiaz-gly-betapyee

140

01/283 / 02PB

3129: ibhs-24thiaz-bala-betabph

3130: phhs-ithiadiaz-bala-betabnaphth

3131: ibhs-ithiadiaz-bala-zdapch

3132: bhs-nme35pyr-nmgly-betaipro

3133: bhs-25thiaz-bala-csdap

3134: tolhs-ithiadiaz-bala-betathiobe

3135: bhs-24thiaz-gly-betadcph

3136: dhim-25thiaz-gly-betadcph

3137: tolhs-25oxaz-bala-betatrif

3138: impy-24thioph-ala-betapy

3139: phhs-25methiaz-gly-betathio3

3140: gua-24thiaz-gly-betapyr

3141: impy-24thiaz-bala-betaftrif

3142: phhs-nme35pyr-bala-betahni

3143: 2py-42nmeim-bala-psdap

3144: ibhs-25thiaz-bala-asppha

3145: phhs-24thioph-bala-psdapch

3146: tolhs-24thiaz-gly-betadmph

3147: bim-24thiaz-gly-betadbph

3148: bhs-42pym-gly-betapy

3149: phhs-25methiaz-bala-betafluo

3150: 2py-35thioph-ala-zdap

3151: tolhs-24thiaz-bala-betaoxaz

3152: phhs-24thioph-bala-betatos

3153: tolhs-oxadiaz-bala-beta23meoph

3154: bhs-ithiadiaz-nmgly-betabpy

3155: tolhs-nme35pyr-bala-betameph

3156: tolhs-ithiadiaz-gly-betacph

3157: bhs-24oxaz-ala-betapy

3158: 2py-24thioph-bala-zdap

3159: bim-25thiaz-bala-betahcbph

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141

3160: phhs-25thiaz-gly-betathiobe 3161: bhs-24thioph-bala-busu2be 3162: phhs-me25oxaz-bala-psdap 3163: phhs-25thiaz-gly-betatos

3164: bhs-25thiaz-nmgly-betabnaphth 3165: tolhs-24thioph-gly-betadcphtb 3166: ibhs-ithiadiaz-gly-betacph

3167: phhs-ithiadiaz-bala-betahph 3168: ibhs-ithiadiaz-bala-betaet 3169: phhs-25methiaz-bala-ibsdap 3170: tolhs-25methiaz-gly-betahdcph 3171: ibhs-25oxaz-bala-betahmphs 3172: -gly-betahmofu 3173: 2py-me25oxaz-bala-betadcph 3174: bhs-nme35pyr-bala-betacthioph 3175: ibhs-24thioph-bala-betaipro 3176: bim-25methiaz-gly-betahmph 3177: sabhs-26py-gly-betyl : phhs-ithiadiaz-gly-psdapch 3179: bim-me25oxaz-bala-betaph 3180: phhs-oxadiaz-bala-betaphethioa 3181: tolhs-ithiadiaz-bala-betainyl 3182: bhs-24thioph-nmgly-betadhbfu 3183h gly-betaol 3184: phhs-ithiadiaz-bala-betabph 3185: 2py-me25thioph-ala-zdap 3186: bim-ithiadiaz-bala-aspaba

3187: dhim-26py-nmgly-zdap

3188: 2py-24thioph-ala-betapy 3189: tolhs-25oxaz-gly-betafu3

3190: tolhs-25oxaz-bala-betahdcph

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142

3191: bhs-ithiadiaz-gly-betatbuph

3192: 2py-25methiaz-bala-betahni

3193: bhs-24thiaz-ala-betaipro

3194: bhs-24thiaz-gly-aspaba

3195: ibhs-nme35pyr-bala-aspibua

3196: bhs-25methiaz-bala-betabmph

3197: bhs-25methiaz-ala-betamesu

3198: bhs-nme35pyr-bala-betadcph

3199: impy-42nmeim-bala-betapy

3200: ibhs-25methiaz-bala-betadbph

3201: ibhs-ithiadiaz-bala-asppha

3202: tolhs-25methiaz-bala-betatrif

3203: ibhs-ithiadiaz-bala-betapym

3204: bhs-nme35pyr-nmgly-betathioph

3205: tolhs-me25oxaz-bala-psdap

3206: tolhs-24thioph-bala-betatbuph

3207: bhs-ithiadiaz-bala-busu2be

3208: tolhs-oxadiaz-bala-aspibua

3209: phhs-ithiadiaz-gly-betafphe

3210: ibhs-25methiaz-gly-betahdbph

3211: bhs-me24oxaz-gly-psdap

3212: bhs-46pym-ala-zdap

3213: bim-25thioph-ala-betainyl

3214: phhs-24thioph-gly-betampy

3215: gua-26py-gly-betaftrif

3216: ibhs-25thiaz-bala-betabmph

3217: ibhs-oxadiaz-gly-betadcph

3218: 2 pmhs-25methiaz-bala-betabmph

3219: bim-ithiadiaz-gly-asppha

3220: phhs-25methiaz-gly-beta34dcph

3221: tolhs-24thioph-gly-betahcbph

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143

3222: bhs-ithiadiaz-nmgly-betafphe

3223: ibhs-ithiadiaz-gly-betaphethio

3224: phhs-25oxaz-bala-zdapch

3225: ibhs-oxadiaz-gly-betamesu

3226: tolhs-oxadiaz-bala-betadcphee

3227: tolhs-ithiadiaz-gly-aspaba

3228: impy-24thioph-bala-busu2be

3229: bhs-24thioph-leu-zdap

3230: ibhs-oxadiaz-bala-betaftrif

3231: gua-26py-gly-betapbiph

3232: ibhs-oxadiaz-gly-betapytb

3233: bim-25fur-gly-betadcph

3234: bhs-24thiaz-gly-psdaptb

3235: ibhs-ithadiaz-gly-beta34meoph

3236: tolhs-25thiaz-bala-betadcphch

3237: phhs-24thioph-bala-betahb

3238: 2py-25thiaz-gly-psdap

3239: tolhs-24thiaz-gly-betahdbph

3240: ibhs-nme35pyr-gly-psdap

3241: bhs-25thiaz-leu-betameph

3242: bhs-25thiaz-bala-betafphe

3243: ibhs-oxadiaz-gly-beta34meoph

3244: phhs-me24oxaz-ala-zdap

3245: ibhs-ithiadiaz-gly-betabpy

3246: bhs-ithiadiaz-gly-betamethi

3247: phhs-25thiaz-bala-csdap

3248: bhs-25thiaz-met-betadcph

3249: 2py-nme35pyr-bala-psdap

3250: bhs-25thiaz-gly-betatos

3251: bhs-25oxaz-gly-betaomebendi

3252: bhs-24thiaz-gly-betapyee

144

01/283 / 02PB

3253: ibhs-oxadiaz-bala-betafphe

3254: gua-24thiaz-nmgly-betapy

3255: ibhs-24thiaz-bala-psdapee

3256: 2py-25methiaz-bala-aspaba

3257: ibhs-25thiaz-gly-betabediox

3258: phhs-me24thiaz-leu-beta34meoph

3259: ibhs-25methiaz-bala-betabthioph

3260: ibhs-25oxaz-gly-betapych

3261: 2py-52thiaz-ala-betaainyl

3262: tolhs-me24thioph-ala-zdap

3263: ibhs-24thioph-gly-betabmph

3264: bhs-25thiaz-gly-zdaptb

3265: phhs-24thioph-bala-ibsdap

3266: bhs-nme35pyr-gly-betahni

3267: bhs-25oxaz-gly-zdapch

3268: phhs-25oxaz-gly-betafu3

3269: phhs-25thiaz-bala-betadmoph

3270: bhs-oxadiaz-nmgly-betadmoph

3271: bhs-25methiaz-gly-betahbcph

3272: tolhs-25methiaz-bala-betabthioph

3273: bhs-oxadiaz-bala-zdapch

3274: gua-24oxaz-gly-betaamibe

3275: phhs-25thiaz-gly-betabpy

3276: bhs-24im-bala-psdap

3277: phhs-24thiaz-bala-asppha

3278: ibhs-ithiadiaz-gly-betadmoph

3279: tolhs-24thioph-bala-suabu

3280: bim-me24oxaz-bala-betadcph

3281: tolhs-oxadiaz-bala-betabph

3282: phhs-24thiaz-bala-betaipro

3283: bhs-oxadiaz-bala-betaipro

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145

3284: phhs-25oxaz-bala-betadtrif

3285: ibhs-25oxaz-gly-betambiph

3286: bhs-nme35pyr-gly-aspibiia

3287: bim-oxadiaz-leu-betapy

3288: bhs-oxadiaz-ala-betaanaphth

3289: 2py-25thiaz-ala-betainyl

3290: 2py-24thiaz-bala-suabu

3291: bhs-24thiaz-bala-betahni

3292: bhs-25methiaz-ser-betapy

3293: phhs-oxadiaz-gly-betaheph

3294: gua-24thiaz-gly-suabu

3295: tolhs-25methiaz-bala-betacph

3296: ibhs-25thiaz-gly-betapy

3297: ibhs-24thioph-bala-betatos

3298: thpym-24thiaz-gly-betahdcph

3299: tolhs-25methiaz-bala-aspibua

3300: thazep-25oxaz-gly-psdap

3301: tolhs-nme35pyr-bala-zdapch

3302: bhs-oxadiaz-gly-betaphethioa

3303: phhs-me24thioph-leu-betaph

3304: phhs-me25oxaz-gly-psdap

3305: tolhs-25methiaz-gly-betamethi

3306: ibhs-25oxaz-bala-betacbph

3307: bhs-25thiaz-leu-betapy

3308: ibhs-ithiadiaz-gly-betahdcph

3309: thpy-24oxaz-gly-betadcph 3310: phhs-25thiaz-bala-betathioph

3311: bim-ithiadiaz-gly-aspaba

3312: tolhs-ithiadiaz-bala-aspbzla

3313: bim-24thioph-ala-zdap

3314: ibhs-25oxaz-gly-betapyr

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146

3315: bhs-24thioph-gly-betaipro

3316: bhs-24thiaz-bala-betaoxope

3317: bhs-nme35pyr-gly-betah35dc

3318: phhs-oxadiaz-bala-betapym

3319: tolhs-24thiaz-bala-betaheph

3320: ibhs-ithiadiaz-gly-betaheph

3321: phhs-24thioph-gly-betaomebendi

3322: ibhs-ithiadiaz-bala-betacthioph

3323: bhs-ithiadiaz-gly-betamesu

3324: nmhs-24thioph-gly-betadcph

3325: ibhs-24thiaz-bala-betatrif

3326: bhs-oxadiaz-bala-betambiph

3327: bhs-oxadiaz-nmgly-betaipro

3328: bim-me24thioph-leu-beta34meoph

3329: 2 pmhs-24thiaz-gly-betahbcph

3330: tolhs-24thiaz-gly-betapy

3331: ibhs-25oxaz-bala-betathiobe

3332: 2 pmhs-42pym-gly-betapy

3333: phhs-25methiaz-bala-betaph

3334: phhs-oxadiaz-gly-betafphe

3335: tolhs-ithiadiaz-gly-betahmo

3336: bhs-25oxaz-nmgly-betathioph

3337: bhs-42nmeim-gly-suabu

3338: ibhs-24thiaz-bala-betah35dc

3339: bgua-24thioph-gly-betameph

3340: phhs-ithiadiaz-gly-betatos

3341: tolhs-oxadiaz-gly-beta34dcph

3342: ibh.s-25methiaz-bala-betaheph

3343: bim-25fur-ala-zdap

3344: bim-24thioph-bala-betadcph

3345: ibhs-25oxaz-bala-betaftrif

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147

3346: ibhs-oxadiaz-gly-beta34dcph

3347: tolhs-25thiaz-gly-betamesu

3348: bhs-oxadiaz-bala-betapy

3349: impy-24thioph-bala-betaphethioa

3350: ibhs-24thioph-gly-betadcph

3351: bhs-ithiadiaz-gly-aspibua

3352: bhs-24oxaz-bala-zdap

3353: tolhs-25thiaz-gly-betapytb

3354: phhs-oxadiaz-bala-betabenfu

3355: tolhs-24thiaz-bala-betahcbph

3356: bim-25thiaz-bala-betacph

3357: ibhs-25methiaz-bala-betatbuph

3358: tolhs-25thiaz-bala-betabthioph

3359: phhs-ithiadiaz-bala-betathio3

3360: ibhs-24thioph-bala-busu2be

3361: 2py-53pyrazo-ala-betadcph

3362: tolhs-oxadiaz-gly-beta35dbph

3363: ibhs-ithiadiaz-bala-betahc

3364: phhs-oxadiaz-bala-betapytb

3365: phhs-oxadiaz-gly-betafbph

3366: tolhs-me24oxaz-gly-betadcph

3367: bhs-25oxaz-bala-betapytb

3368: phhs-24thiaz-gly-betahdbph

3369: bim-26py-ala-betainyl

3370: phhs-24thioph-gly-betambiph

3371: bhs-nme35pyr-gly-betambiph

3372: bhs-ithiadiaz-bala-betamesu

3373: tolhs-nme35pyr-gly-psdapch

3374: bhs-25oxaz-nmgly-betabpy

3375: tolhs-me24thioph-ala-betapy

3376: phhs-24thiaz-gly-betameph

148

01/283 / 02PB

3377: phhs-25oxaz-gly-betaol

3378: bim-24thioph-bala-betahc

3379: bhs-nme35pyr-ala-betabpy

3380: ibhs-24thiaz-gly-betadhbfu

3381: bhs-25oxaz-gly-betahbcph

3382: tolhs-me24oxaz-leu-betaph

3383: 4 pmhs-26py-gly-betapy

3384: ibhs-25thiaz-bala-betahbcph

3385: tolhs-24thiaz-bala-betadcph

3386: tolhs-oxadiaz-bala-betainyl

3387: tolhs-25methiaz-bala-psdap

3388: phhs-me24thioph-bala-betadcph

3389: phhs-oxadiaz-bala-betathio3

3390: phhs-24thioph-bala-asppha

3391: bhs-24thioph-bala-betainyl

3392: bhs-25oxaz-gly-betafluo

3393: ibhs-nme35pyr-bala-psdapee

3394: bim-me25oxaz-leu-betadcph

3395: tolhs-ithiadiaz-bala-betafu2

3396: phhs-25methiaz-gly-betabthioph

3397: bhs-24thiaz-bala-betafbph

3398: ibhs-nme35pyr-bala-betafluo

3399: bhs-ithiadiaz-nmgly-beta13bendi

3400: bhs-24thiaz-gly-betaol

3401: ibhs-oxadiaz-gly-suabu

3402: nmhs-42nmeim-gly-psdap

3403: phhs-25methiaz-bala-asppha

3404: gua-26py-gly-beta34dcph

3405: phhs-ithiadiaz-bala-betadbph

3406: phhs-me25thioph-gly-psdap

3407: bhs-24thiaz-bala-betabediox

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149

3408: bim-25thioph-ala-betadcph

3409: bhs-ithiadiaz-ala-ibsdap

3410: ibhs-25thiaz-bala-aspibua

3411: bhs-24thioph-bala-beta4bph

3412: ibhs-ithiadiaz-bala-betabnaphth

3413: 2py-25methiaz-gly-betathio3

3414: bhs-ithiadiaz-gly-betampy

3415: phhs-nme35pyr-gly-betamethi

3416: ibhs-24thioph-bala-beta34meoph

3417: ibhs-25oxaz-bala-betafu3

3418: phhs-ithiadiaz-gly-betaimide

3419: tolhs-25oxaz-gly-betadcphch

3420: tolhs-24thioph-bala-betafbph

3421: ibhs-25thiaz-bala-betatbuph

3422: bhs-25oxaz-gly-psdaptb

3423: bim-me24thioph-bala-betaph

3424: bhs-24thiaz-gly-beta3quin

3425: bim-me24thiaz-leu-betadcph

3426: phhs-ithiadiaz-gly-beta13bendi

3427: tolhs-25methiaz-gly-aspibua

3428: tolhs-24thiaz-gly-betadhbfu

3429: bhs-42pym-ala-betadcph

3430: ibhs-nme35pyr-bala-betacthoph

3431: bhs-25oxaz-gly-betaanaphth

3432: ibhs-ithiadiaz-gly-betatos

3433: ibhs-nme35pyr-bala-betadcph

3434: ibhs-nme35pyr-bala-betatos

3435: tolhs-nme35pyr-bala-betahbcph

3436: 2py-me25thioph-ala-betaph

3437: ibhs-oxadiaz-gly-busu2be

3438: bim-triaz-bala-zdap

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150

3439: bhs-24thioph-gly-betampy

3440: bhs-35fur-bala-betapy

3441: bhs-me24thioph-leu-beta34meoph

3442: ibhs-25oxaz-bala-betaanaphth

3443: bhs-25oxaz-leu-zdap

3444; gua-24thiaz-gly-betadmoph

3445: bhs-ithiadiaz-bala-betacthioph

3446: bhs-25thiaz-gly-betapyr

3447: ibhs-ithiadiaz-gly-beta34dcph

3448: tolhs-oxadiaz-bala-betaheph

3449: tolhs-oxadiaz-gly-betapyee

3450: gua-24oxaz-gly-betambiph

3451: tolhs-24thioph-gly-betafu3

3452: tolhs-24thiaz-bala-zdaptb

3453: tolhs-ithiadiaz-gly-betaoxope

3454: phhs-nme35pyr-gly-betaftrif

3455: bhs-ithiadiaz-bala-betadcphtb

3456: bim-triaz-bala-psdap

3457: bhs-nme35pyr-gly-betapyr

3458: bhs-25oxaz-bala-betaipro

3459: tolhs-nme35pyr-gly-betabmph

3460: ibhs-24thiaz-bala-betadmph

3461: tolhs-24thiaz-gly-betaphethio

3462: agua-26py-gly-betadcph

3463: 2py-triaz-gly-psdap

3464: 2py-24thiaz-bala-betabnaphth

3465: tolhs-oxadiaz-bala-betaph

3466: ibhs-25methiaz-gly-aspaba

3467: bim-me24thiaz-gly-betaph

3468: bim-me24thioph-ala-betapy

3469: ibhs-24thiaz-bala-betaanaphth

151

01/283 / 02PB

3470: bim-42nmeim-ala-betapy

3471: ibhs-24thioph-bala-betahni

3472: bhs-24thioph-bala-asppha

3473: ibhs-24thiaz-bala-betahph

3474: bhs-25oxaz-bala-betahc

3475: tolhs-24thioph-gly-betah35dc

3476: bim-me24thioph-ala-beta34meoph

3477: bim-me25oxaz-bala-beta34meoph

3478: tolhs-25thiaz-bala-aspaba

3479: ibhs-oxadiaz-bala-betampy

3480: bhs-35thioph-ala-betapy

3481: tolhs-24thioph-bala-betafph

3482: bhs-nme35pyr-bala-ibsdap

3483: 2 pmhs-24thioph-bala-betapyr

3484: phhs-24thiaz-gly-betafphe

3485: bhs-25oxaz-bala-betacbph

3486: tolhs-24thioph-gly-zdaptb

3487: bim-me24thiaz-leu-betapy

3488: bim-ithiadiaz-leu-betapy

3489: ibhs-ithiadiaz-bala-beta34dcph

3490: bhs-oxadiaz-bala-csdap

3491: phhs-25methiaz-bala-aspbzla

3492: 2py-me24oxaz-gly-psdap

3493: bhs-24thioph-gly-csdap

3494: phhs-ithiadiaz-bala-betadcphch

3495: ibhs-nme35pyr-gly-asppha

3496: bhs-oxadiaz-gly-betaftrif

3497: bhs-25methiaz-bala-betabenfu

3498: gua-24thiaz-gly-betaomebendi

3499: bhs-me25thiaz-gly-beta34meoph

3500: bim-25methiaz-bala-betampy is

152

01/283 / 02PB

3501: phhs-25oxaz-gly-betaphethio 3502: tolhs-24thiaz-gly-zdap

3503: bhs-nme35pyr-bala-betacph 3504: bhs-25thiaz-bala-betabnaphth 3507: bhs-nme35pyr-gly-betabdimo 3507: bhs-25thiaz-bala-betaph

3508: tolhs-oxadiaz-gly-betatrif 3509: 2py-me24oxaz-leu-beta34meoph 3510: tolhs-ithiadiaz-bala-betathiome 3511: tolhs-25thiaz-bala-betapych 3512: tolhs-25oxaz-gly-betabediox 3513: tolhs-25meth -bala-betapym 3514: bhs-25thiaz-gly-betambiph 3515: phhs-ithiodiaz-bala-betaoxaz 3516: 2py-42oxaz-bala-betadcph 3517: bhs-nme35pyr-gly-psdapee 3518: gua-24oxaz-gly-betafph

3519: phhs-24thiaz-bala-betafphe 3520: bhs-25thiaz-bala-betapytb 3521: phhs-24thiaz-bala-betapcphch 3522: phhs-25thiaz-bala-betapyr 3523: tolhs-nme35pyr-gly-psdaptb 3524: tolhs -bala-suabu 3525: bhs-42oxaz-bala-betadcph 3526: phhs-25methiaz-gly-betapych 3527: impy-25methiaz-bala-betainyl 3528: phhs-25thiaz-gly-ibsdap

3529: phhs-25oxaz-gly-betabnaphth 3530: bhs-oxadiaz-gly-betatos 3531: tolhs-25thiaz-gly-betambiph

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153

3532: bhs-25methiaz-bala-psdaptb

3533: impy-24thiaz-gly-betathiobe

3534: bhs-25methiaz-bala-betamethioph

3535: bhs-25thiaz-nmgly-betainyl

3536: bhs-ithiadiaz-bala-betadito

3537: gua-24thiaz-gly-betabenfu

3538: ibhs-24thiaz-bala-betadtrif

3539: phhs-me25thioph-leu-betapy

3540: phhs-me25thiaz-gly-betaph

3541: ibhs-ithiadiaz-gly-betabnaphth

3542: ibhs-25oxaz-gly-betahbcph

3543: bhs-25thiaz-nmgly-beta3quin

3544: impy-24thioph-gly-betahmofu

3545: bhs-24thioph-gly-betapym

3546: 2py-52thiaz-gly-zdap

3547: phhs-oxadiaz-bala-betaibph

3548: 2 pmhs-25methiaz-bala-beta4bph

3549: tolhs-25methiaz-gly-betaet

3550: bhs-25thiaz-ala-betahmph

3551: bhs-25thioph-leu-betapy

3552: bhs-25methiaz-gly-suabu

3553: phhs-oxadiaz-bala-suabu

3554: phhs-25thiaz-bala-psdap

3555: phhs-me24thioph-leu-psdap

3556: bim-24thioph-gly-betaibph

3557: ibhs-oxadiaz-gly-betapy

3558: tolhs-24thiaz-bala-betaanaphth

3559: phhs-oxadiaz-bala-betaoxope

3560: bhs-24thiaz-bala-betapyee

3561: ibhs-24thiaz-gly-betahb

3562: tolhs-oxadiaz-bala-betahdbph

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154

3563: bhs-24thiaz-gly-betabph

3564: bhs-ithiadiaz-ala-beta34dcph

3565: ibhs-24thiaz-bala-betatbuph

3566: ibhs-24thiaz-gly-betaipro

3567: bhs-ithiadiaz-ala-betadcph

3568: bhs-25thiaz-bala-betafbph

3569: phhs-25oxaz-gly-zdapch

3570: ibhs-24thiaz-gly-betabediox

3571: ibhs-25methiaz-gly-betadmoph

3572: phhs-24thioph-gly-betaipr

3573: bhs-ithiadiaz-bala-betabph

3574: tolhs-nme35pyr-gly-psdapee

3575: bim-42oxaz-bala-psdap

3576: ibhs-25oxaz-bala-betafluo

3577: tolhs-nme35pyr-gly-betahmo

3578: bhs-25methiaz-bala-aspaba

3579: bhs-25thioph-gly-zdap

3580: phhs-25oxaz-gly-betadmph

3581: bhs-oxadiaz-bala-betapyr

3582: gua-26py-gly-betamethioph

3583: 2py-25thioph-bala-betapy

3584: bhs-oxadiaz-ala-betathioph

3585: bim-thiadiaz-bala-zdap

3586: bim-25oxaz-bala-betamethioph

3587: bhs-25methiaz-nmgly-betamesu

3588: dhpyrr-26py-gly-betadcph

3589: 2py-me25thiaz-gly-beta34meoph

3590: phhs-oxadiaz-gly-betahcbph

3591: 2py-me25thioph-gly-beta34meoph

3592: phhs-25methiaz-gly-betaibph

3593: ibhs-nme35pyr-bala-betamesu

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155

3594: ibhs-24thioph-bala-betabpy

3595: ibhs-24thioph-bala-betadcphee

3596: ibhs-oxadiaz-gly-betacthioph

3597: gua-24oxaz-gly-betathiome

3598: gua-42pym-gly-betaoxope

3599: 2py-25oxaz-gly-aspbzla

3600: bhs-oxadiaz-gly-betadhbfu

3601: phhs-25methiaz-bala-betacthioph

3602: bim-25methiaz-bala-betaipro

3603: ibhs-ithiadiaz-gly-betadito

3604: tolhs-nme35pyr-bala-betahdbph

3605: bim-me24thioph-gly-beta34meoph

3606: phhs-me24thioph-gly-betapy

3607: bhs-35fur-leu-psdap

3608: ibhs-24thiaz-gly-betadmph

3609: dhim-24thiaz-gly-betainyl

3610: bhs-42oxaz-gly-betadcph

3611: ibhs-24thiaz-bala-betaet

3612: phhs-nme35pyr-gly-betahb

3613: gua-24thiaz-gly-betabpy

3614: 2py-52thiaz-gly-psdap

3615: tolhs-25methiaz-bala-suabu

3616: phhs-25oxaz-gly-betabdimo

3617: bhs-nme35pyr-nmgly-betadmph

3618: ibhs-oxadiaz-gly-betadmoph

3619: phhs-nme35pyr-gly-aspaba

3620: phhs-nme35pyr-bala-betamesu

3621: bhs-25thiaz-bala-betathiobe

3622: bhs-24thiaz-leu-psdap

3623: bhs-25thiaz-gly-betadtrif

3624: ibhs-25methiaz-gly-betapyee

156

01/283 / 02PB

3625: bim-35thioph-gly-psdap

3626: bhs-25oxaz-gly-betadtrif

3627: bhs-oxadiaz-bala-betadcph

3628: bim-25thiaz-ala-betapy

3629: 2py-24thiaz-gly-asppha

3630: bhs-oxadiaz-gly-betaamibe

3631: bhs-ithiadiaz-nmgly-beta34dcpth

3632: bim-24thiaz-gly-betameph

3633: phhs-me24oxaz-gly-psdap

3634: bim-me24thiaz-gly-psdap

3635: bhs-oxadiaz-gly-betaheph

3636: thpy-24thioph-gly-betadcph

3637: gua-25thioph-gly-betaoxope

3638: bhs-42pym-gly-betameph

3639: bhs-24thiaz-gly-betafii2

3640: tolhs-25oxaz-gly-betaheph

3641: bhs-25oxaz-nmgly-betahmph

3642: impy-25oxaz-gly-betapym

3643: gua-25thiaz-gly-betamethi

3644: phhs-oxadiaz-bala-betacthioph

3645: bhs-24thioph-gly-betaibph

3646: phhs-25methiaz-bala-betahmofu

3647: bhs-25oxaz-gly-betacthioph

3648: bhs-oxadiaz-bala-betaipr

3649: phhs-24thioph-gly-betaamibe

3650: phhs-nme35pyr-gly-betaamibe

3651: phhs-25methiaz-gly-betaphethio

3652: phhs-25thiaz-gly-betapbiph

3653: ibhs-25oxaz-gly-betapy

3654: tolhs-nme35pyr-gly-aspibua

3655: ibhs-24thiaz-gly-psdapch

157

01/283 / 02PB

3656: 2py-35fur-ala-psdap

3657: tolhs-24thiaz-bala-betaomebendi

3658: ibhs-25methiaz-bala-betadhbfu

3659: ibhs-25methiaz-bala-betaoxaz

3660: bim-25methiaz-gly-asppha

3661: phhs-ithiadiaz-bala-betadmoph

3662: bhs-35fur-ala-betadcph

3663: phhs-25thiaz-bala-betatos

3664: bim-42nmeim-gly-betafu3

3665: bhs-24thioph-gly-beta35dbph

3666: ibhs-nme35pyr-bala-betadhbfu

3667: cima-24thiaz-bala-psdap

3668: tolhs-25methiaz-bala-betaol

3669: gua-26py-gly-betaipr

3670: tolhs-ithiadiaz-bala-betaipr

3671: ibhs-nme35pyr-gly-csdap

3672: tolhs-24thiaz-gly-betafph

3673: phhs-25methiaz-bala-betaphethio

3674: phhs-ithiadiaz-bala-betafphe

3675: tolhs-24thioph-bala-beta23meoph

3676: phhs-25thiaz-bala-aspbzla

3677: tolhs-oxadiaz-gly-betacbph

3678: bhs-24thiaz-ala-betabnaphth

3679: phhs-25methiaz-bala-betapbiph

3680: 2py-24im-ala-psdap

3681: tolhs-24thiaz-bala-betathiobe

3682: pbhs-oxadiaz-gly-betaphethio

3683: tolhs-25oxaz-gly-betahbcph

3684: tolhs-oxadiaz-bala-betacbph

3685: tolhs-25oxaz-gly-beta34meoph

3686: bhs-25oxaz-gly-betathiome

158

01/283 / 02PB

3687: dhim-42nmeim-gly-zdap

3688: ibhs-ithiadiaz-gly-betabthioph

3689: ibhs-oxadiaz-gly-betaet

3690: bhs-25methiaz-nmgly-beta34dcph

3691: ibhs-25oxaz-gly-beta23meoph

3692: phhs-25methiaz-gly-betacph

3693: ibhs-nme35pyr-gly-betathio3

3694: bim-me24thiaz-gly-betadcph

3695: phhs-24thioph-gly-csdap

3696: ibhs-nme35pyr-bala-asppha

3697: 2py-me24thioph-ala-psdap

3698: tolhs-25oxaz-gly-zdapee

3699: dhim-26py-gly-psdap

3700: 2py-25thioph-bala-zdap

3701: tolhs-25oxaz-bala-psdapch

3702: phhs-24thioph-gly-zdapch

3703: bim-thiadiaz-bala-betadcph

3704: bim-24oxaz-bala-betadcph

3705: tolhs-25oxaz-gly-psdap

3706: bim-52thiaz-gly-zdap

3707: ibhs-oxadiaz-bala-betadito

3708: bhs-me24thiaz-bala-zdap

3709: 2py-ithiadiaz-bala-asppha

3710: gua-42pym-gly-betafu2

3711: phhs-25methiaz-bala-betaanaphth

3712: bhs-26py-ala-zdap

3713: ibhs-24thiaz-gly-betaoxope

3714: phhs-24thioph-bala-betadcphee

3715: dhim-52thiaz-ala-betainyl

3716: phhs-ithiadiaz-bala-betaanaphth

3717: bhs-24thioph-gly-betafph

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159

3718: gua-24thiaz-gly-betahb

3719: bhs-oxadiaz-gly-betaipro

3720: phhs-25methiaz-gly-betatrif

3721: bim-me24thioph-gly-zdap

3722: ibhs-oxadiaz-bala-betaoxaz

3723: gua-24thiaz-gly-betacbph

3724: ibhs-ithiadiaz-gly-betahni

3725: bim-ithiadiaz-bala-aspibua

3726: 2py-42oxaz-gly-betadcph

3727: tolhs-ithiadiaz-gly-betaet

3728: ibhs-25methiaz-bala-betahdcph

3729: 2py-42nmeim-gly-betacph

3730: tolhs-oxadiaz-bala-betaanaphth

3731: phhs-ithiadiaz-gly-betaanaphth

3732: phhs-ithiadiaz-gly-betafluo

3733: tolhs-ithiadiaz-bala-betaftrif

3734: phhs-oxadiaz-gly-betaet

3735: phhs-24thiaz-bala-csdap

3736: ibhs-25oxaz-bala-psdap

3737: 2 pmhs-25oxaz-gly-betaol

3738: tolhs-oxadiaz-gly-betadcph

3739: phhs-24thioph-bala-betamesu

3740: bhs-25thiaz-gly-betadito

3741: 2py-42pym-ala-betaainyl

3742: tolhs-me25oxaz-gly-zdap

3743: 2 pmhs-25oxaz-gly-beta3quin

3744: phhs-24thiaz-bala-betahmo

3745: tolhs-24thiaz-bala-csdap

3746: bhs-26py-gly-betapy

3747: bim-53pyrazo-leu-betapy

3748: 2py-25methiaz-gly-zdap

01/283 / 02PB

160

3749: ibhs-nme35pyr-gly-betadtrif

3750: dhim-42pym-ala-betadcph

3751: ibhs-nme35pyr-bala-zdaptb

3752: bim-25thiaz-gly-betadbph

3753: tolhs-25oxaz-bala-betahmph

3754: tolhs-25methiaz-bala-betahph

3755: ibhs-ithiadiaz-gly-betapyr

3756: bhs-ithiadiaz-ala-betaipro

3757: ibhs-25methiaz-bala-psdapch

3758: phhs-nme35pyr-bala-zdapee

3759: bim-me25thiaz-bala-beta34meoph

3760: tolhs-oxadiaz-bala-betahdcph

3761: phhs-oxadiaz-gly-betampy

3762: ibhs-oxadiaz-gly-betathiome

3763: impy-2thioph-gly-betapy

3764: bhs-25oxaz-gly-betainyl

3765: ibhs-25thiaz-bala-betafph

3766: tolhs-ithiadiaz-gly-betafphe

3767: hts-42pym-gly-betapy

3768: ibhs-24thiaz-gly-betahmph

3769: phhs-nme35pyr-bala-betapyee

3770: tolhs-nme35pyr-gly-beta34meoph

3771: bim-me25thioph-bala-betaph

3772: tolhs-24thiaz-bala-betadmph

3773: bhs-ithiadiaz-gly-betaamibe

3774: bhs-25thioph-leu-psdap

3775: bhs-me25thiaz-leu-betaph

3776: bhs-25methiaz-bala-csdap

3777: tolhs-25thiaz-gly-beta4bph

3778: bhs-24thioph-nmgly-betainyl

3779: phhs-oxadiaz-gly-betabenfu

01/283 / 02PB

161

3780: phhs-nme35pyr-gly-psdaptb

3781: gua-24thiaz-gly-betatos

3782: tolhs-oxadiaz-gly-betabdimo

3783: bhs-25thiaz-gly-betafluo

3784: bhs-triaz-ala-psdap

3785: bhs-35pyrazo-gly-betapy

3786: 2 pmhs-24thiaz-bala-betapyr

3787: tolhs-25methiaz-bala-betaphethioa

3788: bhs-24thiaz-bala-betahdbph

3789: ibhs-25thiaz-gly-betadcphee

3790: phhs-24thioph-bala-betadito

3791: phhs-oxadiaz-gly-betabdimo

3792: 2py-24thiazme-gly-betapy

3793: ibhs-nme35pyr-gly-beta34meoph

3794: phhs-ithiadiaz-gly-betahbcph

3795: ibhs-oxadiaz-gly-betaibph

3796: 2py-24thioph-bala-psdap

3797: 2 pmhs-25oxaz-bala-suabu

3798: bhs-24thioph-nmgly-betabpy

3799: ibhs-oxadiaz-bala-asppha

3800: gua-25thiaz-gly-betaomebendi

3801: 3 pmhs-42pym-gly-betapy

3802: tolhs-25thiaz-gly-suabu

3803: ibhs-24thioph-bala-betafu2

3804: tolhs-oxadiaz-bala-psdapch

3805: ibhs-oxadiaz-bala-betadcphtb

3806: phhs-ithiadiaz-bala-betaftrif

3807: ibhs-oxadiaz-gly-betaoxope

3808: 2py-oxadiaz-bala-psdap

3809: tolhs-me25oxaz-gly-psdap

3810: bhs-25methiaz-nmgly-beta13bendi

01/283 / 02PB

162

3811: tolhs-24thiaz-bala-betabpy

3812: hs-42pym-gly-betapy

3813: tolhs-25oxaz-bala-betapbiph 3814: ibhs-oxadiaz-bala-beta34meoph 3815: bhs-ithiadiaz-ala-betameph 3816: phhs-me24oxaz-leu-beta34meoph 3817: bhs-25thiaz-nmgly-betafphe-3818: tol -gly-betafluo 3819: tolhs-25thiaz-bala-betamethi 3820: bhs-24thioph-nmgly-betathio3 3821: bhs-24thiaz-hphe-betapy 3822: tolhs-25methiaz-bala-aspbzla 3823: bim-me25thiaz-al24-betadph : bhs-25thiaz-bala-asppha 3825: bhs-nme35pyr-gly-betamesu 3826: ibhs-ithiadiaz-gly-betapyee 3827: phhs-25oxaz-bala-betabnaphth 3828: ibhs-24thioph-gly-betadmoph 3829iad-phiaz gly-betabnaphth 3830: tolhs-nme35pyr-gly-beta3quin 3831: bhs-me25thioph-bala-betapy 3832: tolhs-nme35pyr-bala-betapym 3833: bhs-nme35pyr-ala-beta3quin 3834: ibhs-25oxaz-gly-bet-35-oxamet-gly-bet-35 tolhs-25thiaz-gly-betaoxaz 3836: phhs-ithiadiaz-bala-betadcphee 3837: tolhs-24thiaz-bala-betaphethioa 3838: 2py-25oxaz-gly-betadcph 3839: tolhs-oxadiaz-bala-betampy 3840: 2py-42oxaz -betapy 3841: ibhs-24thiaz-gly-zdaptb

- -Yeah

01/283 / 02PB 163

3842: phhs-ithiadiaz-bala-psdaptb

3843: phhs-nme35pyr-gly-betafluo

3844: bhs-nme35pyr-gly-zdapee

3845: ibhs-24thioph-bala-betaoxaz

3846: ibhs-24thiaz-bala-betaoxaz

3847: thazep-25thiaz-gly-beta13bendi

3848: bhs-24thioph-ala-betabnaphth

3849: bhs-ithiadiaz-nmgly-betamesu

3850: phhs-oxadiaz-gly-betacph

3851: ibhs-25methiaz-bala-betapyr

3852: 2py-25methiaz-gly-betaol

3853: tolhs-25methiaz-gly-betahbcph

3854: ibhs-25thiaz-bala-betadmph

3855: phhs-25thiaz-gly-beta35dbph

3856: ibhs-25thiaz-gly-csdap

3857: phhs-25thiaz-gly-betamethioph

3858: 2py-24thiaz-gly-betathio3

3859: ibhs-ithiadiaz-bala-betahni

3860: gua-25thioph-gly-betathio3

3861: bhs-oxadiaz-gly-beta34dcph

3862: dhim-25thiophme-ala-betameph

3863: ibhs-nme35pyr-bala-betahdcph

3864: tolhs-nme35pyr-bala-betathio3

3865: bhs-24thioph-gly-betacthioph

3866: phhs-25thiaz-bala-betaol

3867: ibhs-24thiaz-gly-ibsdap

3868: bhs-me24im-gly-betameph

3869: tolhs-24thiaz-gly-betabnaphth

3870: tolhs-me25thiaz-bala-zdap

3871: 2py-35fur-bala-zdap

3872: tolhs-oxadiaz-bala-betabthioph

164

01/283 / 02PB

3873: bhs-ithiadiaz-gly-betahph

3874: bgua-25methiaz-gly-betameph

3875: phhs-ithiadiaz-bala-betabediox

3876: phhs-25methiaz-bala-betadcph

3877: ibhs-nme35pyr-gly-betapbiph

3878: tolhs-25methiaz-gly-betabenfu

3879: bim-25thiaz-bala-psdap

3880: bhs-25methiaz-gly-betaet

3881: phhs-me25thioph-bala-psdap

3882: tolhs-25thiaz-gly-betaoxope

3883: tolhs-ithiadiaz-gly-betafu2

3884: ibhs-oxadiaz-bala-betabpy

3885: bim-25methiaz-gly-aspaba

3886: ibhs-nme35pyr-bala-betaamibe

3887: bhs-25methiaz-bala-betainyl

3888: bhs-ithiadiaz-gly-psdapee

3889: bgua-25oxaz-bala-betapy

3890: phhs-25methiaz-gly-betamesu

3891: phhs-25methiaz-bala-betaftrif

3892: ibhs-25thiaz-bala-betaanaphth

3893: ibhs-oxadiaz-bala-beta3quin

3894: phhs-25methiaz-bala-zdapch

3895: phhs-nme35pyr-bala-ibsdap

3896: 2 pmhs-25methiaz-bala-betathioph

3897: bhs-me24thiaz-leu-betapy

3898: phhs-25thiaz-bala-betathiome

3899: tolhs-25thiaz-gly-betapbiph

3900: gua-25thioph-gly-betahmo

3901: bim-25thioph-bala-betapy

3902: tolhs-oxadiaz-bala-beta35dbph

3903: tolhs-ithiadiaz-gly-aspbzla

01/283 / 02PB

165

3904: tolhs-nme35pyr-bala-betacthioph

3905: bhs-triaz-gly-psdap

3906: ibhs-oxadiaz-bala-betadhbfu

3907: phhs-me25oxaz-leu-zdap

3908: tolhs-oxadiaz-gly-betamethioph

3909: bhs-25oxaz-bala-betadbph

3910: bhs-oxadiaz-bala-betameph

3911: phhs-24thiaz-gly-aspaba

3912: bim-25thiaz-bala-betaimide

3913: 2py-24thioph-leu-betadcph

3914: ibhs-25oxaz-gly-betaanaphth

3915: ibhs-nme35pyr-gly-betapyr

3916: tolhs-24thioph-gly-beta35dbph

3917: 2 pmhs-25methiaz-bala-betapyr

3918: tolhs-25thiaz-gly-betadmph

3919: 2py-25methiaz-leu-betapy

3920: bhs-oxadiaz-bala-asppha

3921: bhs-25oxaz-gly-betahb

3922: tolhs-24thioph-bala-betameph

3923: phhs-me25oxaz-leu-beta34meoph

3924: 2py-42nmeim-bala-betapy

3925: phhs-me25thiaz-ala-betapy

3926: phhs-25methiaz-bala-betampy

3927: ibhs-25oxaz-bala-suabu

3928: bhs-oxadiaz-gly-betabmph

3929: bhs-25oxaz-bala-betambiph

3930: tolhs-nme35pyr-gly-aspbzla

3931: ibhs-nme35pyr-gly-betapych

3932: ibhs-24thiaz-gly-betaph

3933: bhs-24thiaz-bala-betacthioph

3934: bhs-me25oxaz-leu-beta34meoph

01/283 / 02PB

166

3935: bhs-25oxaz-bala-betahbcph

3936: tolhs-25oxaz-bala-betafbph

3937: tolhs-25methiaz-bala-betabmph

3938: bhs-nme35pyr-nmgly-betadhbfu

3939: phhs-25methiaz-bala-betahni

3940: bhs-24thioph-bala-beta34meoph

3941: 2py-24thioph-gly-betadito

3942: bhs-25oxaz-gly-betahph

3943: bhs-25methiaz-gly-psdaptb

3944: ibhs-nme35pyr-gly-betapym

3945: ibhs-ithiadiaz-gly-betadmph

3946: bim-24im-leu-zdap

3947: impy-25thiaz-gly-beta34meoph

3948: ur-42pym-ala-psdap

3949: bhs-ithiadiaz-bala-betafbph

3950: bhs-24thiaz-gly-betatos

3951: ibhs-24thioph-gly-zdapee

3952: tolhs-25methiaz-bala-betadcphtb

3953: ibhs-ithiadiaz-bala-betahmo

3954: ibhs-nme35pyr-bala-betahb

3955: phhs-25oxaz-gly-betaet

3956: ibhs-24thiaz-gly-betathio3

3957: bhs-25methiaz-gly-betahmph

3958: bhs-42oxaz-ala-psdap

3959: gua-25thiaz-gly-betapy

3960: ibhs-nme35pyr-bala-betahbcph

3961: phhs-nme35pyr-bala-betathiome

3962: bim-25methiaz-bala-psdap

3963: bhs-24thiaz-ala-betadmph

3964: phhs-25methiaz-gly-betathiome

3965: phhs-me25thioph-bala-betadcph

01/283 / 02PB

167

3966: bhs-ithiadiaz-bala-betathiome

3967: bhs-nme35pyr-bala-betathioph

3968: bim-24thioph-bala-betaimide

3969: phhs-24thioph-gly-betaftrif

3970: bhs-25thiaz-gly-betadcph

3971: phhs-me25thioph-gly-betaph

3972: bim-25methiaz-ala-betapy

3973: bhs-24thioph-ala-betathio3

3974: ibhs-24thiaz-bala-aspbzla

3975: phhs-oxadiaz-bala-betahmph

3976: bhs-ithiadiaz-ala-betaanaphth

3977: bhs-25oxaz-gly-aspaba

3978: bhs-ithiadiaz-gly-betaol

3979: 2py-thiadiaz-leu-betadcph

3980: phhs-me25oxaz-bala-betapy

3981: ibhs-25oxaz-gly-beta34dcph

3982: ibhs-oxadiaz-gly-betabmph

3983: bhs-oxadiaz-bala-beta4bph

3984: tolhs-24thiaz-bala-betafu3

3985: bhs-25oxaz-bala-betafu2

3986: tolhs-me25thiaz-ala-psdap

3987: tolhs-25oxaz-bala-betamesu

3988: 2py-26py-gly-betahdcph

3989: bhs-25methiaz-met-betadcph

3990: bhs-me25oxaz-bala-beta34meoph

3991: bim-me24thioph-gly-betaph

3992: bhs-25oxaz-gly-betaibph

3993: phhs-oxadiaz-gly-betahdbph

3994: tolhs-me25oxaz-ala-betadcph

3995: 2py-25fur-gly-zdap

3996: bim-thiadiaz-leu-betapy

01/283 / 02PB

168

3997: tolhs-24thiaz-bala-betathioph

3998: 2py-24thioph-gly-betathio3

3999: bhs-24thiaz-gly-betahmo

4000: phhs-nme35pyr-gly-betabenfu '

4001: ibhs-25thiaz-bala-betapych

4002: bhs-24oxaz-ala-zdap

4003: impy-24thiaz-bala-betamethi

4004: ibhs-oxadiaz-gly-betaphethio

4005: tolhs-25thiaz-bala-betaet

4006: phhs-25methiaz-bala-betahmph

4007: phhs-oxadiaz-bala-betadito

4008: bim-25fur-ala-betadcph

4009: tolhs-oxadiaz-bala-beta34meoph

4010: bhs-24thioph-ala-betamesu

4011: phhs-25thiaz-gly-betadmoph

4012: bhs-nme35pyr-ala-betaipro

4013: tolhs-25thiaz-gly-betabpy

4014: ibhs-nme35pyr-gly-betaipr

4015: bhs-25methiaz-gly-betabmph

4016: tolhs-25oxaz-bala-betapych

4017: tolhs-oxadiaz-gly-csdap

4018: tolhs-nme35pyr-bala-beta35dbph

4019: 2py-me25thioph-leu-beta34meoph

4020: phhs-oxadiaz-bala-betahni

4021: ibhs-24thioph-bala-betadmph

4022: bhs-25methiaz-gly-betadito

4023: bhs-42nmeim-ala-betadcph

4024: ibhs-25oxaz-bala-betaphethioa

4025: bim-me24thiaz-bala-zdap

4026: bhs-42py-gly-betameph

4027: tolhs-24thioph-gly-betahmph ιι «* ΙΗΙ ·· ί

169

01/283 / 02PB

4028: bim-me24thioph-ala-zdap

4029: bim-me25thiaz-gly-beta34meoph

4030: bhs-25thiaz-bala-betabthioph

4031: bim-25thiaz-gly-aspaba

4032: gua-24thiaz-gly-betafbph

4033: thpym-42pym-gly-betahcbph

4034: bhs-nme35pyr-bala-betaamibe

4035: bhs-25oxaz-gly-betapbiph

4036: phhs-25thiaz-gly-betahc

4037: 2py-nme35pyr-bala-aspibua

4038: bim-24oxaz-gly-betadcph

4039: phhs-24thioph-gly-betahbcph

4040: 2py-me25thioph-leu-betapy

4041: bhs-me25thioph-ala-psdap

4042: bhs-me25oxaz-leu-betapy

4043: tolhs-ithiadiaz-bala-betahmofu

4044: 2py-25thiaz-bala-betabnaphth

4045: bim-24thiaz-gly-betadmph

4046: ibhs-24thiaz-gly-betaol

4047: tolhs-25thiaz-gly-betafbph

4048: bhs-42nmeim-bala-betapy

4049: phhs-25methiaz-gly-betahb

4050: phhs-25thiaz-bala-betacbph

4051: tolhs-nme35pyr-gly-zdapee

4052: phhs-ithiadiaz-bala-zdaptb

4053: thazep-25thiaz-bala-zdap

4054: 2py-24chin-gly-betapy

4055: ibhs-25methiaz-gly-betapytb

4056: bhs-25thiaz-bala-betadcphtb

4057: phhs-25methiaz-bala-beta13bendi

4058: tolhs-24thiaz-gly-betapbiph

01/283 / 02PB

170

4059: bhs-ithiadiaz-gly-betaipr

4060: 2py-35thioph-gly-zdap

4061: phhs-me25thiaz-gly-zdap

4062: ibhs-24thioph-bala-betadcph

4063: tolhs-25oxaz-gly-betambiph

4064: bhs-nme35pyr-gly-betahmph

4065: bhs-25methiaz-ala-psdap

4066: tolhs-25thiaz-bala-betafph

4067: tolhs-ithiadiaz-gly-betabph

4068: tolhs-nme35pyr-bala-aspaba

4069: 2py-42oxaz-ala-zdap

4070: ibhs-nme35pyr-bala-betadcphch

4071: 2py-24thiaz-ala-betameph

4072: 2py-24thiaz-gly-betaol

4073: ibhs-25methiaz-bala-betapych

4074: 2 pmhs-24thiaz-gly-betadtrif

4075: dhim-26pyrazi-gly-betameph

4076: tolhs-24thiaz-gly-betadcph

4077: ibhs-nme35pyr-bala-betapym

4078: ibhs-25methiaz-bala-betahb

4079: bhs-24thioph-bala-betadcph

4080: ibhs-oxadiaz-gly-betapyee

4081: bhs-25thiaz-gly-aspibua

4082: bim-me25thiaz-leu-betadcph

4083: phhs-25methiaz-bala-betatos

4084: phhs-me25thiaz-ala-psdap

4085: bhs-25methiaz-ala-ibsdap

4086: bim-52thiaz-ala-betadcph

4087: phhs-24thiaz-bala-betambiph

4088: phhs-ithiadiaz-gly-beta3quin

4089: bhs-24thioph-gly-betapbiph

01/283 / 02PB

171

4090: 2py-25oxaz-bala-betaftrif

4091: bhs-oxadiaz-ala-betameph

4092: tolhs-oxadiaz-bala-betaoxaz

4093: ibhs-oxadiaz-bala-betaibph

4094: bhs-24thiaz-gly-betaph

4095: ibhs-nme35pyr-gly-betafbph

4096: tolhs-nme35pyr-gly-betaanaphth

4097: phhs-24thiaz-gly-betamesu

4098: bhs-25oxaz-ala-betadcph

4099: tolhs-ithiadiaz-bala-betaimide

4100: impy-25oxaz-gly-betabph

4101: dhim-42pym-gly-betadtrif

4102: 2py-me25thioph-bala-betapy

4103: ibhs-24thioph-gly-betadtrif

4104: 2py-me24thioph-bala-beta34meoph

4105: bhs-25thiaz-nmgly-ibsdap

4106: phhs-nme35pyr-bala-betahmo

4107: phhs-25oxaz-gly-betaheph

4108: gua-42pym-gly-betainyl

4109: gua-42pym-gly-betaomebendi

4110: bhs-25thiaz-bala-betahbcph

4111: tolhs-25oxaz-bala-betabthioph

4112: bhs-nme35pyr-nmgly-betahmph

4113: ibhs-25oxaz-gly-betadmoph

4114: tolhs-nme35pyr-bala-betabmph

4115: tolhs-nme35pyr-bala-betapbiph

4116: bhs-25oxaz-bala-betahdcph

4117: impy-24thioph-bala-betamethi

4118: bim-me24oxaz-gly-beta34meoph

4119: phhs-me25oxaz-ala-betapy

4120: bim-me24thioph-gly-psdap

01/283 / 02PB

172

4121: bhs-24thioph-gly-betahph

4122: phhs-24thioph-gly-betaol

4123: ibhs-25thiaz-bala-zdaptb

4124: tolhs-nme35pyr-gly-betaamibe

4125: bhs-24thiaz-bala-betahb

4126: bhs-24thiaz-gly-zdapch

4127: gua-42pym-gly-betapyr 4128: phhs-oxadiaz-gly-zdapee

4129: bim-25thiaz-ala-psdap

4130: bhs-ithiadiaz-gly-betapy 4131: bhs-25methiaz-gly-betacph 4132: ibhs-25oxaz-gly-betaet

4133: 2py-42py-gly-betapy

4134: 2py-25oxaz-gly-betapy 4135: bhs-oxadiaz-gly-betafph 4136: ibhs-24thioph-gly-beta3quin 4137: tolhs-25oxaz-bala-betadcphee

4138: 2py-me25oxaz-ala-psdap 4139: bhs-24thioph-nmgly-betadito 4140: bhs-nme35pyr-gly-betahdcph 4141: bhs-oxadiaz-bala-betamethi 4142: bhs-nme35pyr-gly-betadcphee 4143: bhs-nme35pyr-gly-betadcphee -bala-betaibph 4144: bhs-24thioph-bala-beta23meoph 4145: ibhs-oxadiaz-bala-betatos 4146: tolhs-ithiadiaz-bala-betadtrif 4147: bhs-oxadiaz-gly-betapych 4148: toihs-ithiadiaz-bala-beta-beta-beta-beta-beta-beta-4149 : bhs-24thiaz-bala-betadbph 4150: bhs-24thioph-bala-betaphethioa 4151: phhs-25oxaz-bala-betadcphch

01/283/02 P B

173

4152: tolhs-24thiaz-gly-betafluo

4153: phhs-25methiaz-gly-betaimide

4154: tolhs-oxadiaz-gly-betadtrif

4155: bhs-nme35pyr-ala-betadmph

4156: bim-25thiaz-bala-betampy

4157: phhs-25methiaz-bala-betathioph

4158: phhs-nme35pyr-gly-zdapch

4159: bhs-25methiaz-gly-betatos

4160: tolhs-25oxaz-bala-betahc

4161: 2py-me24thiaz-ala-beta34meoph

4162: tolhs-me24thioph-gly-beta34meoph

4163: bim-oxadiaz-gly-betadcph

4164: ibhs-25thiaz-bala-betapbiph

4165: bhs-25thiaz-bala-betatos

4166: 2py-25methiaz-bala-betapy

4167: tolhs-25methiaz-bala-zdapch

4168: gua-42pym-gly-betafluo

4169: bhs-nme35pyr-bala-betaphethioa

4170: tolhs-24thioph-bala-psdapee

4171: phhs-25oxaz-gly-ibsdap

4172: ibhs-25thiaz-gly-betabnaphth

4173: 2py-25thiaz-gly-beta35dbph

4174: ibhs-oxadiaz-gly-betaimide

4175: bhs-me25thioph-ala-betapy

4176: phhs-24thioph-gly-betathioph

4177: ibhs-24thiaz-gly-betaomebendi

4178: bim-25thiaz-ala-zdap

4179: ibhs-25methiaz-bala-betahmph

4180: ibhs-24thioph-gly-betahbcph

4181: bim-25oxaz-gly-betahbcph

4182: bhs-ithiadiaz-gly-betadito

01/283 / 02PB

174

4183: bhs-24thioph-nmgly-betaipro

4184: bim-35thioph-ala-zdap

4185: ibhs-25oxaz-gly-betadcphch

4186: phhs-24thiaz-bala-zdapee

4187: bhs-me24thiaz-bala-betaph

4188: bim-nme35pyr-ala-zdap

4189: tolhs-25thiaz-gly-betaomebendi

4190: bhs-24thioph-gly-psdapee

4191: tolhs-nme35pyr-bala-zdap

4192: tolhs-nme35pyr-gly-aspaba

4193: ibhs-oxadiaz-bala-betatbuph

4194: tolhs-25oxaz-gly-betameph

4195: 2py-thiadiaz-bala-betadcph

4196: bim-24im-gly-betapy

4197: phhs-24thioph-gly-betadtrif

4198: bhs-nme35pyr-bala-betabph

4199: 2py-24thioph-bala-aspibua

4200: bhs-25methiaz-bala-betafbph 4201: bhs-24thiaz-bala-betaibph

4202: impy-25thiaz-nmgly-psdap

4203: phhs-oxadiaz-gly-betatos

4204: phhs-24thioph-gly-beta13bendi

4205: bim-triaz-leu-betadcph

4206: phhs-25methiaz-bala-csdap

4207: phhs-nme35pyr-gly-betainyl

4208: ibhs-nme35pyr-bala-beta4bph

4209: phhs-ithiadiaz-bala-betahni

4210: 2py-24thiaz-ala-psdap

4211: tolhs-25thiaz-bala-beta4bph

4212: bhs-25thiaz-gly-beta34dcph

4213: bhs-25thiaz-bala-betafu3

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175

4214: phhs-24thioph-gly-beta35dbph 4215: phhs-24thiaz-gly-betadmoph 4216: bhs-oxadiaz-ala-beta 13bendi 4217: 2 pmhs-25oxaz-bala-betafluo 4218: phhs-25oxaz-gly-zdaptb 4219: phhs- 24thiaz-bala-betamesu 4220: ibhs-24thioph-gly-betaph 4221: tolhs-nme35pyr-gly-betafphe 4222: bhs-25methiaz-gly-betabthioph 4223: bhs-25thiaz-bala-psdap 4224: tolhs-25methiaz-gly-betaibb 4225: bhs-me25oxaz-leu-betadcph 4226: 2 pmhs-25oxaz-bala-beta34dcph 4227: 2 pmhs-24thiaz-bala-betabmph 4228: bim-24im-ala-betapy 4229: phhs-25thiaz-gly-betathio3 4230: ibhyr-n-beta-n-42 -gly-betahbcph 4231: tolhs-25oxaz-bala-betaol 4232: phhs-nme35pyr-bala-zdapch 4233: phhs-24thiaz-gly-betacph 4234: ibhs-24thioph-gly-betamethi 4235: 2 pmhs-25thiaz-gly-betabpy 4236 : phhs-24thioph-bala-zdapee 4237: phhs-oxadiaz-bala-betapyee 4238: ibhs-24thioph-gly-csdap 4239: tolhs-oxadiaz-bala-betapyr 4240: bim-25thiaz-bala-aspibua 4241: bhs-oxadiaz- gly-ibsdap 4242: bim-53pyrazo-leu-betadcph 4243: bhs-ithiadiaz-bala-betafu3 4244: tolhs-ithiadiaz-bala-bet ambiph

01/283/02 P B

176

4245: ibhs-25methiaz-bala-betabdimo 4246: impy-25thiaz-gly-betathiobe 4247: bhs-oxadiaz-gly-betaanaphth 4248: tolhs-25thiaz-bala-betahdbph 4249: bhs-oxadiaz-bala-betathio3 4250ur: bhs-25thaz -leu-betadcph 4251: 2py-me25thioph-ala-betadcph 4252: phhs-24thioph-bala-betamethi 4253: 2 pmhs-25oxaz-gly-psdap 4254: bhs-oxadiaz-gly-betahmo 4255: phhs-nme35pyr-bala-aspbzla 4251: 2 : nmhs-25thiaz-gly-betadcph 4257: bhs-24thiaz-ala-betadmoph 4258: impy-25thiaz-bala-psdap 4259: bim-24oxaz-gly-betapy 4260: bhs-25oxaz-gly-suabu 4261: bim-25thioph- gly-betapy 4262: bim-25methiaz-bala-aspibua 4263: bhs-oxadiaz-gly-betahdcph 4264: ibhs-24thiaz-bala-betacthioph 4265: tolhs-24thiaz-gly-betaamibe 4266: tolhs-24thioph-bala-beta3quin 4267: ibhs-25thiaz-bala-betamesu 4268: phhs-oxadiaz-bala-zdapee 4269: ibhs-24thiaz-bala-betahmofu 4270: bhs-25methiaz-bala-betaet 4271: ibhs-25thiaz-gly-betaheph 4272: ibhs-24thiaz -beta34meoph 4273: ibhs-nme35pyr-bala-betathioph 4274: bhs-25methiaz-bala-betafluo 4275: bim-25oxaz-ala -betapy

01/283 / 02PB

177

4276: phhs-24thioph-bala-betapbiph

4277: tolhs-24thiaz-gly-betadito

4278: bim-42oxaz-ala-psdap

4279: bhs-24thiophme-gly-zdap

4280: tolhs-24thiaz-bala-betadcphtb

4281: bhs-25thiaz-bala-betabpy

4282: phhs-me25oxaz-leu-betaph

4283: phhs-nme35pyr-gly-beta3quin

4284: bhs-oxadiaz-bala-betabthioph

4285: bim-nme35pyr-bala-aspibua

4286: bhs-25thiaz-bala-betaphethio

4287: ibhs-25thiaz-bala-betaoxaz

4288: bhs-nme35pyr-gly-zdaptb

4289: ibhs-25oxaz-bala-busu2be

4290: bhs-25methiaz-nmgly-betadmoph

4291: tolhs-oxadiaz-bala-betameph

4292: bhs-24thiaz-gly-betabiph

4293: ibhs-25methiaz-bala-betapym

4294: tolhs-nme35pyr-gly-betathioph

4295: tolhs-25methiaz-bala-psdapch

4296: 2py-25thiaz-gly-asppha

4297: tolhs-24thiaz-bala-betahc

4298: 2 pmhs-25thioph-gly-betapy

4299: ibhs-24thiaz-bala-betaph

4300: impy-25methiaz-bala-betamethi

4301: phhs-oxadiaz-gly-betathiobe

4302: ibhs-25thiaz-gly-betathioph

4303: gua-25thiaz-gly-betacthioph

4304: phhs-24thioph-gly-beta3quin

4305: phhs-oxadiaz-bala-betafph

4306: phhs-ithiadiaz-bala-betaoxope

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178

4307: tolhs-25methiaz-bala-betahdcph

4308: bhs-24oxaz-leu-psdap

4309: ibhs-24thiaz-bala-betahdcph

4310: gua-24thiaz-gly-betahc

4311: phhs-24thiaz-bala-betadbph

4312: 2 pmhs-25oxaz-gly-betatbuph

4313: ibhs-24thioph-bala-psdap

4314: bim-24thioph-bala-betapy

4315: tolhs-24thiaz-gly-beta13bendi

4316: pahs-25thiaz-gly-betapy

4317: thazep-24thiaz-bala-zdap

4318: phhs-24thioph-gly-betameph

4319: impy-24thioph-gly-betaipr

4320: 2py-42nmeim-bala-betatrif

4321: phhs-24thiaz-gly-psdapee

4322: phhs-oxadiaz-gly-beta35dbph

4323: thpym-24thiaz-gly-betacbph

4324: phhs-24thiaz-bala-zdap

4325: ibhs-24thioph-bala-betapyee

4326: tolhs-ithiadiaz-gly-betaipro

4327: bhs-26py-gly-zdap

4328: phhs-ithiadiaz-bala-beta13bendi

4329: ibhs-25methiaz-gly-betaheph

4330: bhs-nme35pyr-gly-betacph

4331: bhs-thiadiaz-leu-zdap

4332: tolhs-24thiaz-gly-betafu3

4333: 2py-ithiadiaz-leu-psdap

4334: thpym-42pym-gly-beta35dbph

4335: bhs-35fur-leu-zdap

4336: bim-me25thiaz-ala-psdap

4337: bim-thiadiaz-bala-betapy

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179

4338: bhs-25thiaz-bala-betadcphee

4339: ibhs-ithiadiaz-bala-betadhbfu

4340: phhs-24thiaz-bala-betafu2

4341: bhs-oxadiaz-bala-aspibua

4342: tolhs-25thiaz-gly-betamethioph

4343: bhs-25oxaz-nmgly-betadhbfu

4344: 3 pmhs-24thiaz-bala-betapy

4345: 2py-42pym-ala-zdap

4346: tolhs-24thioph-gly-betaoxaz

4347: phhs-25oxaz-bala-betaimide

4348: bim-25oxaz-bala-aspibua

4349: phhs-nme35pyr-gly-betathiobe

4350: ibhs-24thioph-bala-betahc

4351: bhs-nme35pyr-bala-zdapee

4352: 2py-24thiaz-bala-betaoxope

4353: bhs-25thiaz-ala-betamesu

4354: phhs-25methiaz-bala-betah35dc

4355: bhs-25oxaz-gly-betacbph

4356: tolhs-25thiaz-gly-beta3quin

4357: bhs-oxadiaz-gly-betadbph

4358: tolhs-25oxaz-bala-betameph

4359: phhs-24thiaz-gly-beta4bph

4360: 2py-me25thiaz-leu-betadcph

4361: 2py-nme35pyr-gly-betapy

4362: bhs-25oxaz-bala-betacph

4363: bhs-25methiaz-bala-beta13bendi

4364: dhim-25thiaz-gly-psdap

4365: 2py-42nmeim-bala-betadbph

4366: bhs-ithiadiaz-gly-betapytb

4367: phhs-ithiadiaz-bala-betatos

4368: tolhs-oxadiaz-bala-betafu3

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180

4369: 2py-24thiaz-gly-aspbzla

4370: bhs-25oxaz-bala-betaibph

4371: ibhs-ithiadiaz-gly-betahb

4372: ibhs-25thiaz-bala-betadcph

4373: ibhs-24thiaz-gly-beta23meoph

4374: tolhs-nme35pyr-bala-betatbuph

4375: bhs-24thioph-bala-betapyr

4376: ibhs-nme35pyr-gly-betahcbph

4377: bhs-53pyrazo-gly-psdap

4378: pahs-24thiaz-bala-betameph

4379: ibhs-oxadiaz-gly-betabpy

4380: tolhs-nme35pyr-gly-betatrif

4381: phhs-25thiaz-bala-betabdimo

4382: ibhs-25oxaz-bala-betaheph

4383: tolhs-24thiaz-gly-betaibph

4384: 2py-triaz-ala-betapy

4385: bhs-25methiaz-gly-betadmph

4386: phhs-25thiaz-bala-betaibph

4387: ibhs-25thiaz-gly-betahcbph

4388: phhs-oxadiaz-bala-beta35dbph

4389: bim-nme35pyr-ala-psdap

4390: phhs-25oxaz-bala-betahmofu

4391: bim-25thiaz-bala-betatos

4392: ibhs-25oxaz-bala-psdapee

4393: hts-24thioph-gly-betapy

4394: bhs-25methiaz-bala-beta4bph

4395: bhs-me25thiaz-gly-betapy

4396: bhs-25methiaz-gly-betaibph

4397: bhs-25oxaz-bala-betaanaphth

4398: bhs-25thiaz-gly-betaphethio

4399: phhs-24thiaz-bala-beta23meoph

01/283 / 02PB

181

4400: tolhs-24thiaz-gly-csdap

4401: phhs-oxadiaz-gly-betaol

4402: ibhs-nme35pyr-gly-aspibua

4403: pahs-25oxaz-gly-betapy

4404: bhs-oxadiaz-bala-beta13bendi

4405: phhs-24thioph-gly-betafbph

4406: ibhs-25thiaz-gly-betaimide

4407: bhs-oxadiaz-nmgly-betabnaphth

4408: phhs-25oxaz-gly-betainyl

4409: bim-ithiadiaz-gly-aspbzla

4410: tolhs-24thioph-gly-betacph

4411: bhs-nme35pyr-gly-betaphethio

4412: 2py-42oxaz-gly-betapy

4413: ibhs-24thiaz-bala-betamesu

4414: bhs-24thioph-bala-betahb

4415: tolhs-oxadiaz-bala-betahph

4416: bhs-nme35pyr-bala-betapytb, 4417: tolhs-24thiaz-gly-betahc

4418: bim-35thioph-leu-betadcph

4419: bhs-25methiaz-bala-betahmo

4420: bim-me25thioph-gly-beta34meoph

4421: 4 pmhs-25thiaz-gly-betapy

4422: phhs-25thiaz-bala-betahmph

4423: phhs-25methiaz-gly-aspbzla

4424: gua-24thiaz-gly-betacthioph

4425: thpym-25thioph-gly-betacbph

4426: dhim-25thiaz-gly-betapy

4427: ibhs-25methiaz-bala-zdap

4428: bhs-25methiaz-bala-busu2be

4429: bim-24thioph-gly-betahmph

4430: phhs-nme35pyr-gly-betaipro

01/283 / 02PB

182

4431: bhs-me24oxaz-ala-beta34meoph

4432: bhs-nme35pyr-ala-betacthioph

4433: bim-42oxaz-ala-betapy

4434: bhs-24thioph-gly-betadmph

4435: phhs-25methiaz-gly-betahbcph

4436: tolhs-24thioph-gly-betathiobe

4437: ibhs-25oxaz-bala-betaoxaz

4438: ibhs-nme35pyr-bala-betameph

4439: tolhs-ithiadiaz-gly-betapbiph

4440: bim-24thioph-bala-aspbzla

4441: 2py-nme35pyr-leu-betapy

4442: dhthi-24oxaz-gly-betapy

4443: tolhs-24thioph-gly-betadmph

4444: phhs-25thiaz-bala-psdaptb

4445: 2py-me25oxaz-gly-beta34meoph

4446: tolhs-oxadiaz-gly-betapyr

4447: bhs-24thiaz-gly-betamethi

4448: bhs-24thiaz-bala-betaph

4449: bhs-oxadiaz-bala-betahdcph

4450: gua-25thioph-gly-betahcbph

4451: 2py-52thiaz-gly-betainyl

4452: tolhs-oxadiaz-bala-betacthioph

4453: 2py-25methiaz-gly-betadcph

4454: bhs-oxadiaz-gly-betatrif

4455: tolhs-24thioph-gly-betabmh

4456: tolhs-25methiaz-bala-betadcph

4457: bim-triaz-ala-betadcph

4458: bhs-nme35pyr-gly-beta3quin

4459: phhs-24thioph-gly-betahb

4460: phhs-25thiaz-gly-betafbph

4461: impy-42nmeim-bala-betadtrif

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183

4462: phhs-24thiaz-bala-suabu

4463: tolhs-24thioph-bala-betapyr

4464: bhs-25thiaz-ala-betadmoph

4465: bhs-25thiaz-bala-betah35dc

4466: hts-24thiaz-gly-betapy

4467: phhs-ithiadiaz-bala-betahdcph

4468: ibhs-24thiaz-bala-betamethioph

4469: bim-oxadiaz-gly-psdap

4470: bim-oxadiaz-leu-zdap

4471: ibhs-oxadiaz-gly-ibsdap

4472: tolhs-me24thioph-leu-beta34meoph

4473: phhs-ithiadiaz-bala-aspaba

4474: ibhs-oxadiaz-bala-betah35dc

4475: phhs-25methiaz-bala-betapych

4476: phhs-24thioph-gly-betabph

4477: impy-25thiaz-gly-betambiph

4478: bhs-25thiaz-gly-betafu2

4479: ibhs-oxadiaz-gly-psdapee

4480: bhs-24thioph-bala-betaimide

4481: tolhs-24thioph-gly-psdap

4482: ibhs-oxadiaz-bala-psdapch

4483: phhs-24thiaz-gly-betabthioph

4484: bim-26py-gly-betadcph

4485: bhs-24thioph-bala-betahmph

4486: ibhs-25oxaz-gly-betafphe

4487: bhs-25oxaz-gly-betaipr

4488: tolhs-24thiaz-gly-betahdcph

4489: gua-24oxaz-gly-betahmofu

4490: tolhs-24thioph-bala-betacph

4491: tolhs-24thioph-gly-beta34meoph

4492: bhs-oxadiaz-bala-beta35dbph

01/283 / 02PB

184

4493: phhs-ithiadiaz-gly-betaet 4494: bim-24thioph-bala-csdap 4495: bhs-25methiaz-gly-zdaptb 4496: bhs-nme35pyr-bala-betaphethio 4497: ibhs-24thiaz-gly-betathioph 4498: tolhs-24thth -bala-betapych 4499: tolhs-oxadiaz-gly-betadcphch 4500: bhs-ithiadiaz-leu-betadcph 4501: phhs-nme35pyr-gly-betaimide 4502: tolhs-24thiaz-gly-betahni 4503: 2py-26py-gly-csdap 4504 : bhs-triaz-bala-zdap

4505: tolhs-25oxaz-bala-betapyee 4506: phhs-oxadiaz-gly-betabediox 4507: bhs-25thiaz-gly-betapy

4508: tolhs-ithiadiaz-bala-beta23meoph 4509: gua-26py-gly-betambiph 4510: 2 pmhs-24thioph-gly-betameph 4511: phhs-oxadiaz-bala-betaipro 4512: tolhs-nme35pyr-gly-betaimide 4513: tolhyr-nme35 -gly-beta34dcph 4514: phhs-25thiaz-bala-betabpy 4515: 2py-24thioph-gly-psdap

4516: ibhs-24thioph-gly-betadcphch 4517: phhs-25methiaz-gly-betafphe 4518: tolhs-25methiaz-bala-betambiph 4519: tolhs-24thiaz-bala-betatrif

4520: phhs-oxadiaz-gly-betahc

4521: bim-oxadiaz-bala-zdap

4522: phhs-25methiaz-bala-betahb 4523: phhs-25methiaz-gly-zdapee

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185

4524: bim-25thiaz-gly-betadmph

4525: phhs-25oxaz-gly-betatbuph

4526: phhs-25oxaz-gly-zdapee

4527: bhs-nme35pyr-ala-betahmph

4528: 2py-me24thiaz-ala-zdap

4529: tolhs-ithiadiaz-bala-betahdbph

4530: ibhs-24thiaz-gly-zdapee

4531: tolhs-25methiaz-bala-betadcphee

4532: phhs-nme35pyr-bala-betaanaphth

4533: bhs-nme35pyr-bala-betaanaphth

4534: tolhs-nme35pyr-gly-betathiome

4535: ibhs-25methiaz-gly-betacthioph

4536: bhs-24thioph-gly-betah35dc

4537: bim-24oxaz-ala-psdap

4538: ibhs-oxadiaz-gly-betadcphee

4539: tolhs-oxadiaz-bala-betaol

4540: ibhs-ithiadiaz-bala-aspbzla

4541: 2py-26py-ala-zdap

4542: tolhs-oxadiaz-gly-betafu3

4543: bhs-me24thioph-leu-zdap

4544: dhpyrr-24oxaz-gly-betameph

4545: bhs-24thiaz-gly-psdap

4546: tolhs-oxadiaz-bala-betambiph

4547: phhs-24thioph-gly-betafphe

4548: tolhs-ithiadiaz-bala-betacbph

4549: phhs-24thiaz-bala-betadcphee

4550: ibhs-25oxaz-gly-betampy

4551: phhs-oxadiaz-bala-aspaba

4552: bim-25oxaz-bala-betapyr

4553: phhs-25oxaz-bala-beta35dbph

4554: ibhs-25thiaz-bala-ibsdap

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186

4555: ibhs-nme35pyr-gly-betaoxope

4556: tolhs-oxadiaz-gly-betabpy

4557: phhs-nme35pyr-bala-beta3quin

4558: tolhs-nme35pyr-gly-betamesu

4559: bhs-24thiaz-bala-betacph

4560: ibhs-nme35pyr-bala-betaheph

4561: 2 pmhs-24thioph-bala-beta4bph

4562: bhs-thiadiaz-bala-betapy

4563: phhs-nme35pyr-bala-betadbph

4564: 2py-26py-gly-betapy

4565: bim-me24thioph-ala-psdap

4566: tolhs-me24thioph-ala-betaph

4567: phhs-24thioph-bala-betacthioph

4568: phhs-ithiadiaz-bala-betapym

4569: bhs-24thiaz-bala-betatrif

4570: phhs-25thiaz-bala-betaimide

4571: bhs-24thiaz-bala-betaet

4572: 2 pmhs-24thioph-bala-beta13bendi

4573: 2py-me24thiaz-leu-psdap

4574: tolhs-24thioph-bala-betaph

4575: ibhs-25oxaz-gly-betahmo

4576: phhs-nme35pyr-bala-betapytb

4577: tolhs-ithiadiaz-gly-betadmph

4578: tolhs-ithiadiaz-gly-betahmofu

4579: phhs-24thioph-bala-betahcbph

4580: phhs-25methiaz-gly-beta4bph

4581: phhs-nme35pyr-bala-betafluo

4582: tolhs-24thiaz-gly-betah35dc

4583: ibhs-25methiaz-gly-betaet

4584: ibhs-25methiaz-bala-betabmph

4585: tolhs-25oxaz-gly-betahph

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187

4586: bhs-ithiadiaz-nmgly-betameph

4587: ibhs-ithiadiaz-bala-ibsdap

4588: 2 pmhs-25thiaz-bala-zdap

4589: bhs-25oxaz-gly-beta3quin

4590: ibhs-ithiadiaz-gly-psdap

4591: tolhs-ithiadiaz-bala-betathio3

4592: phhs-24thiaz-bala-betahdbph

4593: phhs-25methiaz-bala-betafu2

4594: bhs-nme35pyr-bala-betafphe

4595: ibhs-24thioph-gly-betapym

4596: tolhs-25thiaz-gly-csdap

4597: ibhs-nme35pyr-gly-betafphe

4598: gua-24thiaz-gly-betabediox

4599: bim-25thioph-gly-betameph

4600: 2py-25oxaz-gly-zdap

4601: ibhs-ithiadiaz-gly-betabediox

4602: bhs-25oxaz-gly-betabediox

4603: ibhs-25methiaz-bala-betah35dc

4604: bhs-24thiazme-ala-betameph

4605: gua-24thiaz-gly-betaimide

4606: bhs-25thiaz-gly-betaipro

4607: ibhs-25methiaz-bala-betafu2

4608: bhs-24thioph-bala-psdapee

4609: phhs-24thiaz-gly-betah35dc

4610: bhs-52thiaz-ala-psdap

4611: ibhs-25oxaz-gly-betapyee

4612: ibhs-25thiaz-gly-psdap

4613: nmhs-25oxaz-bala-zdap

4614: tolhs-24thiaz-gly-betabdimo

4615: bhs-25thiaz-ala-beta23meoph

4616: gua-24thiaz-gly-betampy

01/283 / 02PB

188

4617: tolhs-ithiadiaz-gly-betatrif

4618: bhs-42pym-ala-betameph

4619: bhs-25methiaz-ala-betacthioph

4620: phhs-oxadiaz-bala-betadcphtb

4621: bhs-24thioph-bala-betafu3

4622: tolhs-25oxaz-bala-betafu2

4623: bhs-25oxaz-bala-betaamibe

4624: bim-25methiaz-gly-betadcph

4625: gua-24thiaz-gly-betacph

4626: bhs-24thiaz-nmgly-beta34meoph

4627: tolhs-me25thioph-bala-betaph

4628: bhs-nme35pyr-gly-betafluo

4629: ibhs-25thiaz-bala-betahmph

4630: phhs-25oxaz-bala-betaph

4631: tolhs-me24thioph-ala-beta34meoph

4632: bhs-nme35pyr-gly-beta35dbph

4633: dimethpym-24thiaz-gly-betadcph

4634: ibhs-25methiaz-bala-betaimide

4635: ibhs-24thioph-bala-betabthioph

4636: tolhs-nme35pyr-bala-betapyee

4637: hyd-25thiaz-gly-betainyl

4638: tolhs-25oxaz-bala-betapyr

4639: bhs-ithiadiaz-gly-betahdcph

4640: bhs-oxadiaz-bala-betadmoph

4641: phhs-me25oxaz-ala-betadcph

4642: phhs-25methiaz-bala-betameph

4643: bhs-24thiaz-gly-betahc

4644: bhs-me24thioph-leu-betapy

4645: ibhs-25methiaz-bala-betahc

4646: phhs-me24oxaz-ala-betaph

4647: phhs-24thiaz-gly-betahmofu

01/283 / 02PB

189

4648: bhs-ithiadiaz-ala-betadmoph

4649: dimethpym-25thioph-gly-betahdcph

4650: bim-25methiaz-bala-betadcph

4651: bhs-24thioph-nmgly-betadmoph

4652: tolhs-25methiaz-bala-betatbuph

4653: phhs-24thiaz-gly-betathiome

4654: phhs-25oxaz-gly-psdaptb

4655: ibhs-ithiadiaz-bala-betapbiph

4656: ibhs-nme35pyr-bala-betaet

4657: tolhs-25thiaz-bala-zdaptb

4658: bhs-25thiaz-gly-beta3quin

4659: bim-52thiaz-ala-betainyl

4660: bhs-24thioph-ala-betadito

4661: 2py 42nmeim-ala-psdap

4662: phhs-25thiaz-gly-beta3quin

4663: tolhs-oxadiaz-bala-beta13bendi

4664: ibhs-25methiaz-gly-betabmph

4665: ibhs-25methiaz-bala-beta23meoph

4666: bhs-24thioph-gly-betahb

4667: tolhs-oxadiaz-gly-betafluo

4668: gua-24thiaz-gly-betabph

4669: ibhs-25oxaz-gly-aspaba

4670: bhs-25oxaz-ala-zdap

4671: tolhs-25thiaz-bala-betahni

4672: bim-42nmeim-gly-betamesu

4673: dhthi-24thiaz-gly-betapy

4674: phhs-nme35pyr-bala-psdap

4675: ibhs-25oxaz-gly-betatos

4676: bhs-nme35pyr-gly-betapyee

4677: 2py-24thiaz-bala-psdap

4678: tolhs-oxadiaz-gly-betah35dc

01/283 / 02PB

190

4679: tolhs-24thioph-bala-betapytb

4680: gua-24thiaz-gly-beta34dcph

4681: phhs-24thioph-bala-zdap

4682: bhs-ithiadiaz-bala-betahni

4683: gua-25thiaz-gly-betampy

4684: phhs-nme35pyr-bala-beta34dcph

4685: tolhs-nme35pyr-bala-betahph

4686: bhs-24thioph-ala-betameph

4687: phhs-25thiaz-bala-betabediox

4688: ibhs-24thioph-gly-betahmph

4689: tolhs-nme35pyr-bala-betahmph

4690: bhs-25oxaz-gly-betampy

4691: bhs-ithiadiaz-bala-beta4bph

4692: phhs-25methiaz-gly-betadtrif

4693: bhs-me25thiaz-gly-zdap

4694: phhs-25oxaz-gly-busu2be

4695: bhs-nme35pyr-bala-betafu2

4696: ibhs-25methiaz-bala-betathiobe

4697: ibhs-25oxaz-gly-betabdimo

4698: bim-ithiadiaz-ala-psdap

4699: tolhs-oxadiaz-gly-betaimide

4700: ibhs-24thioph-gly-betaftrif

4701: 2py-me25thiaz-ala-betadcph

4702: ibhs-25methiaz-bala-suabu

4703: bhs-24thiaz-bala-betafu3

4704: ibhs-25thiaz-gly-beta13bendi

4705: bim-53pyrazo-gly-zdap

4706: bhs-nme35pyr-bala-betapych

4707: bhs-25methiaz-bala-betahdcph

4708: phhs-24thiaz-gly-betaphethio

4709: ibhs-25methiaz-gly-betahmofu

01/283 / 02PB

191

4710: bhs-25oxaz-bala-betahmofu

4711: phhs-25methiaz-gly-betafbph

4712: ibhs-24thiaz-gly-betamethi

4713: ibhs-25methiaz-gly-psdap

4714: phhs-nme35pyr-bala-betadmph

4715: phhs-oxadiaz-gly-beta13bendi

4716: tolhs-24thiaz-bala-betadcphee

4717: bhs-ithiadiaz-gly-betatos

4718: ibhs-25oxaz-gly-betaphethioa

4719: ibhs-nme35pyr-gly-beta4bph

4720: bhs-oxadiaz-nmgly-betahph

4721: tolhs-ithiadiaz-bala-betahcbph

4722: bhs-25thiaz-gly-betabdimo

4723: bhs-24thiaz-ala-ibsdap

4724: phhs-25methiaz-bala-betafph

4725: bhs-ithiadiaz-gly-betambiph

4726: gua-25methiaz-bala-betadcph

4727: bhs-nme35pyr-ala-betathioph

4728: ibhs-25thiaz-gly-betadcphtb

4729: bhs-nme35pyr-bala-betahni

4730: ibhs-24thiaz-bala-betaamibe

4731: bhs-me24thiaz-ala-zdap

4732: phhs-24thiaz-gly-betaph

4733: ibhs-25methiaz-gly-betahb

4734: bhs-24thiaz-gly-betatrif

4735: bhs-25oxaz-gly-aspbzla

4736: phhs-nme35pyr-gly-betadmoph

4737: bim-25oxaz-ala-zdap

4738: gua-24thiaz-gly-betaibph

4739: ibhs-nme35pyr-gly-betapyee

4740: dhim-25thiaz-gly-zdap

01/283 / 02PB

192

4741: tolhs-25methiaz-bala-beta3quin

4742: tolhs-me24thioph-bala-betadcph

4743: ibhs-oxadiaz-bala-betaomebendi

4744: tolhs-25thiaz-gly-betaheph

4745: bhs-53pyrazo-leu-betapy

4746: bim-25fur-bala-psdap

4747: bim-25thiaz-leu-psdap

4748: bim-42nmeim-bala-zdap

4749: gua-26py-gly-betabmph

4750: bim-me25thiaz-leu-beta34meoph

4751: bim-oxadiaz-bala-asppha

4752: bhs-24im-gly-betapy

4753: tolhs-25thiaz-bala-betadtrif

4754: phhs-25methiaz-bala-betapyr

4755: 2py-24thiaz-gly-betadito

4756: ibhs-24thioph-gly-betadmph

4757: phhs-oxadiaz-bala-psdaptb

4758: bhs-me24thioph-ala-betapy

4759: tolhs-me25thiaz-leu-psdap

4760: tolhs-24thiaz-bala-beta35dbph

4761: pahs-24thiaz-gly-betapy

4762: dhim-25thioph-ala-betapy

4763: bhs-24thioph-bala-betahmo

4764: bhs-me24oxaz-ala-betaph

4765: ibhs-25oxaz-gly-betatbuph

4766: thpym-26py-gly-betainyl

4767: bhs-25methiaz-bala-beta23meoph

4768: phhs-24thiaz-bala-betabpy

4769: 2py-53pyrazo-ala-zdap

4770: tolhs-25methiaz-bala-betabpy

4771: phhs-oxadiaz-bala-betahdcph

01/283 / 02PB

193

4772: bhs-24thioph-gly-betamethioph 4773: phhs-ithiadiaz-gly-betahdbph 4774: phhs-25thiaz-gly-zdaptb

4775: bhs-ithiadiaz-gly-betabthioph 4776: bhs-25thiaz-bala-betadcphch 4779: bhs-24thioph-bala-beta34dcph 4779: tolhs-25methiaz-gly-betatbuph 4780: bhs-24thioph-bala-beta34dcph -bala-aspaba

4781: thpym-25thiaz-gly-beta35dbph 4782: gua-26py-gly-betacph

4783: ibhs-oxadiaz-bala-betadcph 4784: ibhs-24thiaz-gly-betainyl 4785: bim-24py-gly-zdap

4786: 2py-52thiaz-ala-zdap

4787: phhs-24thiaz-gly-beta13bendi 4788: ibhs-ithiadiaz-bala-busu2be 4789: bhs-35thioph-ala-betadcph 4790: phhs-25oxaz-bala-beta34dcph 4791: bhs-24thiaz-gly-betabthioph-2492: phhs -bala-betaamibe 4793: bhs-24thioph-gly-betadcph 4794: tolhs-ithiadiaz-gly-betatbuph 4795: ibhs-nme35pyr-bala-betaol 4796: tolhs-25methiaz-gly-betacbph 4797: phhs-24thiaz-bala-beta-47 : tolhs-24thiaz-bala-betaipro 4799: bhs-25thiaz-ala-betaipro 4800: bhs-25thiaz-bala-betaamibe 4801: tolhs-24thiaz-bala-betambiph 4802: bhs-triaz-gly-betapy

01/283/02 P B

194

4803: bhs-25oxaz-gly-betathioph

4804: bhs-25oxaz-bala-betafu3

4805: ibhs-25oxaz-bala-zdapch

4806: bhs-35thioph-bala-betadcph

4807: phhs-oxadiaz-bala-betadcphch

4808: phhs-ithiadiaz-bala-asppha

01/283/02 / PB

195

4809: bim-me24thiaz-gly-beta34meoph

4810: ibhs-25methiaz-gly-betaftrif

4811: 3 pmhs-25methiaz-bala-betapy

4812: ibhs-25thiaz-gly-betadhbfu

4813: tolhs-24thioph-gly-betaipr

4814: ibhs-25thiaz-gly-betabmph

4815: bhs-25methiaz-bala-zdaptb

4816: bhs-25thiaz-ala-betaheph

4817: bhs-ithiadiaz-bala-betahmph

4818: bim-42pym-gly-betadcph

4819: bhs-25methiaz-gly-psdap

4820: phhs-25oxaz-gly-betacph

4821: bhs-nme35pyr-gly-zdap

4822: bhs-oxadiaz-bala-beta34meoph

4823: tolhs-me24thiaz-leu-betapy

4824: ibhs-25oxaz-bala-betahc

4825: bhs-25methiaz-bala-betahmph

4826: ibhs-24thiaz-bala-zdapch

4827: tolhs-25methiaz-gly-betadmph

4828: 2py-26py-gly-betadcph

4829: dhim-24thiaz-ala-betadcph

4830: bhs-24thiaz-ala-betacph

4831: phhs-ithiadiaz-bala-aspibua

4832: bhs-25thiaz-ala-betahph

4833: phhs-24thioph-bala-betahdcph

4834: bhs-24thiaz-nmgly-betathioph

4835: tolhs-ithiadiaz-gly-asppha

4836: ibhs-24thioph-gly-betaphethioa

4837: phhs-24thiaz-bala-psdap

4838: phhs-25oxaz-bala-betathio3

4839: ibhs-24thioph-gly-betatbuph

01/283/02 / PB

196

4840: ibhs-nme35pyr-gly-betadcphee 4841: phhs-me24thiaz-bala-zdap 4842: ibhs-24thioph-bala-betahdbph 4843: tolhs-25thiaz-bala-betaipr 4844: gua-26py-gly-betabenfu 4845: ibhs -bala-betadtrif 4846: dhim-24thiaz-gly-betahcbph 4847: dhim-25thiaz-ala-betadcph 4848: tolhs-24thioph-gly-betabnaphth 4849: bhs-24thiaz-bala-betahmo 4850: ibhs-oxadiaz-bala-betadbph 4848: : phhs-25methiaz-bala-betahmo 4852: ibhs-25methiaz-gly-betapy 4853: tolhs-25methiaz-gly-zdapch 4854: phhs-25oxaz-bala-betahcbph 4855: tolhs-nme35pyr-bala-betaet 4856: tolhs-ithiad bala-betapytb 4857: nmhs-24thiaz-gly-betadcph 4858: phhs-25thiaz-gly-betaibph 4859: tolhs-24thiaz-bala-betabph 4860: tolhs-25oxaz-bala-betaanaphth 4861: bhs-24thioph-bala-betabthioph 4858 phhs-oxadiaz-gly-betadmoph 4863: bim-me25oxaz-ala-psdap 4864: ibhs-25methiaz-bala-betahdbph 4865: bhs-24thioph-ala-betacph 4866: ibhs-24thioph-bala-betadhbfu 4867: ibhp-b-b-b-b-b-b-48 -betaipr 4868: bim-25oxaz-bala-zdap 4869: bim-42nmeim-leu-zdap 4870: ibhs-oxadi az-gly-betahdbph

01/283/02 / PB

197

4871: phhs-me24oxaz-ala-beta34meoph

4872: bhs-oxadiaz-bala-betahmo

4873: phhs-24thiaz-bala-betadhbfu

4874: bhs-25fur-bala-zdap

4875: tolhs-me25thioph-gly-betapy

4876: ibhs-25thiaz-gly-betafph

4877: 2py-me24thiaz-bala-betapy

4878: phhs-ithiadiaz-bala-beta4bph

4879: phhs-me25thioph-gly-zdap

4880: ibhs-24thioph-bala-betapytb

4881: dhim-26py-gly-betadcph

4882: phhs-25methiaz-gly-betaoxope

4883: bhs-25thiaz-bala-betapy

4884: bim-25thiaz-gly-betapbiph

4885: phhs-25thiaz-bala-betahb

4886: bhs-ithiadiaz-gly-beta3quin

4887: ibhs-25thiaz-gly-betacthioph

4888: bhs-25methiaz-bala-ibsdap

4889: bim-42pym-ala-betainyl

4890: bhs-24thiaz-bala-betapym

4891: bim-25thiaz-bala-csdap

4892: bhs-25oxaz-gly-betamesu

4893: bhs-24thioph-ala-betahmph

4894: ibhs-25methiaz-bala-betahcbph

4895: tolhs-ithiadiaz-bala-psdapch

4896: tolhs-24thiaz-gly-betampy

4897: bhs-triaz-bala-psdap

4898: bhs-nme35pyr-gly-betabnaphth

4899: phhs-oxadiaz-bala-betabnaphth

4900: tolhs-25thiaz-bala-betamethioph

4901: tolhs-oxadiaz-gly-betadbph

198

01/283/02 / PB

4902: tolhs-nme35pyr-bala-betadhbfu

4903: bhs-24thiaz-ala-betaanaphth

4904: ibhs-25thiaz-gly-betadcphch

4905: bhs-oxadiaz-gly-betapbiph

4906: ibhs-ithiadiaz-gly-betampy

4907: tolhs-25thiaz-gly-aspaba

4908: bhs-nme35pyr-bala-betabdimo

4909: tolhs-oxadiaz-gly-betadcphtb

4910: tolhs-oxadiaz-bala-beta3quin

4911: bim-oxadiaz-bala-psdap

4912: phhs-25methiaz-bala-beta34meoph

4913: phhs-24thiaz-gly-betaftrif

4914: bhs-nme35pyr-gly-betacbph

4915: ibhs-oxadiaz-bala-suabu

4916: bhs-triaz-bala-betadcph

4917: 2py-24oxaz-leu-betapy

4918: dhim-42pym-ala-betainyl

4919: phhs-25oxaz-gly-betaftrif

4920: tolhs-25thiaz-bala-betaanaphth

4921: bhs-thiadiaz-bala-psdap

4922: tolhs-24thioph-bala-betainyl

4923: tolhs-25oxaz-gly-betathioph

4924: bhs-42pym-ala-betapy

4925: 2py-26py-gly-beta23meoph

4926: phhs-ithiadiaz-gly-betahph

4927: phhs-25methiaz-gly-betapym

4928: ibhs-25methiaz-bala-betacthioph

4929: bhs-24thiaz-gly-betabenfu

4930: tolhs-25thiaz-bala-betaphethioa

4931: bhs-25thiaz-gly-ibsdap

4932: ibhs-25thiaz-bala-betainyl

199

01/283/02 / PB tolhs-24thioph-bala-psdaptb ibhs-24thiaz-bala-betadhbfu bhs-nme35pyr-bala-betaoxope tolhs-25methiaz-gly-beta13bendi ibhs-24thiaz-gly-beta34dcph bim-me24oxaz-me24oxaz-me24oxaz -nme35pyr-bala-betapbiph dhim-26py-ala-betadcph phhs-25methiaz-gly-betacthioph 2py-42nmeim-bala-zdap ibhs-25thiaz-gly-betahbcph ibhs-25thiaz-gly-betacph ibhs-25acaz-glyac-glyac 25thiaz-bala-betadcph dhim-24oxaz-gly-betameph bhs-nme35pyr-gly-betatrif bhs-24thioph-bala-betahph bhs-nme35pyr-bala-aspibua bhs-25thiaz-gly-betamesu bim-me24oxaz-bala-betaph bhs -bala-betahb bim-ithiadiaz-ala-zdap phhs-oxadiaz-bala-betabmph bhs-oxadiaz-ala-betadito phhs-ithiadiaz-bala-betatbuph bhs-25oxaz-nmgly-betaipro 2py-25fur-leu-psdap bh gly-asppha ibhs-25methiaz-gly-psdapch tolhs-25thiaz-gly-psdap bhs-oxadiaz-bala-betaet

01/283/02 / PB

200

4964: bhs-24thioph-bala-betamethioph

4965: bim-24thioph-gly-aspibua

4966: phhs-me25thioph-ala-betaph

4967: tolhs-nme35pyr-gly-ibsdap

4968: ibhs-24thioph-bala-beta23meoph

4969: tolhs-oxadiaz-bala-betadhbfu

4970: 2py-25thiaz-gly-betadito

4971: phhs-ithiadiaz-gly-betahc

4972: phhs-24thioph-bala-betahbcph

4973: bhs-25methiaz-bala-betah35dc

4974: gua-25thioph-gly-betacph

4975: phhs-oxadiaz-gly-beta23meoph

4976: ibhs-24thioph-gly-betah35dc

4977: phhs-24thioph-gly-betaanaphth

4978: bim-24thiaz-bala-csdap

4979: 2py-24thiaz-gly-betameph

4980: tolhs-24thioph-bala-betambiph

4981: 2py-24im-leu-betadcph

4982: tolhs-nme35pyr-bala-betah35dc

4983: bhs-25oxaz-gly-ibsdap

4984: ibhs-25methiaz-gly-ibsdap

4985: tolhs-ithiadiaz-gly-betameph

4986: bhs-24thiaz-bala-betainyl

4987: bim-me25thiaz-bala-betadcph

4988: tolhs-25methiaz-bala-beta35dbph

4989: bhs-me25oxaz-gly-betaph

4990: phhs-25thiaz-gly-betadhbfu

4991: cima-42nmeim-bala-betapy

4992: phhs-24thiaz-bala-betabthioph

4993: bim-24thioph-leu-psdap

4994: tolhs-me25oxaz-bala-beta34meoph

01/283/02 / PB

201

4995: ibhs-oxadiaz-bala-betainyl

4996: ibhs-ithiadiaz-bala-betaipr

4997: tolhs-nme35pyr-bala-betatos

4998: 3 pmhs-25thioph-gly-betapy

4999: 2py-25thiaz-gly-aspaba

5000: bim-25methiaz-leu-betapy

5001: bim-24thiaz-bala-betadcph

5002: bhs-24thioph-gly-ibsdap

5003: 2py-53pyrazo-gly-psdap

5004: ibhs-24thioph-gly-betaamibe

5005: tolhs-me24thiaz-gly-betapy

5006: bhs-52thiaz-gly-betameph

5007: ibhs-ithiadiaz-bala-betathioph

5008: ibhs-25thiaz-gly-betadmph

5009: bim-24im-gly-zdap

5010: ibhs-24thioph-bala-psdaptb

5011: bim-24thioph-bala-aspibua

5012: bhs-ithiadiaz-nmgly-betahmph

5013: bhs-25thiaz-bala-betainyl

5014: phhs-25methiaz-gly-betacbph

5015: bim-25thiaz-gly-betainyl

5016: phhs-24thioph-gly-betabediox

5017: phhs-oxadiaz-gly-betabnaphth

5018: ibhs-nme35pyr-gly-betabediox

5019: phhs-25thiaz-bala-betah35dc

5020: tolhs-nme35pyr-bala-beta34meoph

5021: phhs-me24thiaz-gly-psdap

5022: phhs-24thioph-bala-betabdimo

5023: tolhs-nme35pyr-gly-betaipro

5024: ibhs-25thiaz-gly-betaomebendi

5025: phhs-25oxaz-gly-betabmph

01/283/02 / PB

202

5026: dhim-26py-ala-betainyl

5027: thpym-26py-gly-betacbph

5028: ibhs-24thiaz-bala-betapytb

5029: ibhs-25thiaz-bala-betaimide

5030: ibhs-ithiadiaz-gly-betaol

5031: ibhs-oxadiaz-bala-beta34dcph

5032: phhs-me25oxaz-gly-betaph

5033: tolhs-24thioph-bala-betafphe

5034: ibhs-24thioph-bala-betaftrif

5035: bim-42pym-ala-betapy

5036: bhs-nme35pyr-ala-betacph

5037: tolhs-nme35pyr-gly-betabenfu

5038: bim-42oxaz-ala-zdap

5039: ibhs-25oxaz-bala-betampy

5040: phhs-25thiaz-gly-betafphe

5041: dhim-26py-gly-beta34meoph

5042: ibhs-24thiaz-gly-betathiome

5043: bim-me24thioph-bala-betapy

5044: bim-24im-bala-zdap

5045: bhs-ithiadiaz-bala-betahbcph

5046: 2py-25thiaz-gly-betadcph

5047: bim-me25oxaz-bala-betadcph

5048: phhs-25methiaz-bala-betathiobe

5049: ibhs-25oxaz-bala-beta3quin

5050: phhs-oxadiaz-bala-beta34meoph

5051: gua-42pym-gly-betabthioph

5052: bhs-35thioph-bala-betapy

5053: 2py-42pym-gly-betainyl

5054: phhs-ithiadiaz-gly-beta4bph

5055: bhs-24thioph-bala-betahdcph

5056: ibhs-25methiaz-bala-betahni

01/283/02 / PB

203

5057: bim-25methiaz-leu-psdap

5058: tolhs-me25oxaz-ala-beta34meoph

5059: ibhs-25thiaz-bala-betampy

5060: phhs-25methiaz-gly-betaoxaz

5061: 2 pmhs-42pym-gly-betainyl

5062: tolhs-nme35pyr-gly-betapyr

5063: tolhs-25methiaz-bala-betapych

5064: tolhs-oxadiaz-gly-betadito

5065: tolhs-me25oxaz-ala-psdap

5066: bhs-ithiadiaz-bala-beta3quin

5067: 2py-25oxaz-ala-psdap

5068: bim-24thioph-leu-betapy

5069: tolhs-25methiaz-bala-betahmo

5070: bhs-25methiaz-bala-zdapch

5071: bhs-24thiaz-bala-betamethi

5072: 2 pmhs-24thioph-bala-betamethioph

5073: bim-24thioph-gly-aspaba

5074: ibhs-25methihz-gly-betatrif

5075: bhs-24thioph-gly-beta3quin

5076: ibhs-oxadiaz-gly-betatrif

5077: 2py-triaz-bala-betapy

5078: phhs-24thioph-bala-betameph

5079: bim-25oxaz-gly-psdap

5080: tolhs-nme35pyr-bala-betabthioph

5081: tolhs-25thiaz-gly-betahmph

5082: bhs-42nmeim-ala-betapy

5083: tolhs-25oxaz-bala-beta34meoph

5084: ibhs-24thiaz-gly-betameph

5085: bim-me24thioph-bala-betadcph

5086: 2py-26py-gly-betabiph

5087: ibhs-25thiaz-bala-betaheph

01/283/02 / PB

204

5088: bhs-25thiaz-nmgly-betadhbfu

5089: tolhs-oxadiaz-gly-betameph

5090: bhs-nme35pyr-nmgly-beta34meoph

5091: dhpyrr-24thiaz-gly-betapy

5092: tolhs-25oxaz-bala-betathioph

5093: bhs-24thiaz-bala-betaipro

5094: bhs-25oxaz-ala-betamesu

5095: ibhs-24thioph-gly-betathiobe

5096: nmhs-25methiaz-gly-betadcph

5097: phhs-24thiaz-gly-aspibua

5098: bhs-oxadiaz-gly-betapytb

5099: bim-24thiaz-bala-psdap

5100: ibhs-nme35pyr-bala-betabenfu

5101: ibhs-24thiaz-bala-betaomebendi

5102: ibhs-25thiaz-bala-betabnaphth

5103: 2py-25oxaz-leu-betapy

5104: phhs-ithiadiaz-gly-aspbzla

5105: ibhs-25thiaz-bala-betabdimo

5106: 2py-me24thioph-gly-betadcph

5107: tolhs-oxadiaz-bala-betaipro

5108: ibhs-24thiaz-bala-betahmph

5109: bhs-25thiaz-gly-aspaba

5110: 2py-35thioph-ala-betapy

5111: bhs-24thioph-gly-zdaptb

5112: phhs-nme35pyr-gly-betatrif

5113: tolhs-25oxaz-gly-betaphethioa

5114: thazep-24thiaz-gly-betadcph

5115: tolhs-ithiadiaz-gly-betadcphch

5116: phhs-25oxaz-bala-betafbph

5117: tolhs-25methiaz-gly-betamethioph

5118: impy-24thiaz-gly-betambiph

01/283/02 / PB

205

5119: phhs-oxadiaz-bala-betafu3

5120: tolhs-me24thiaz-leu-zdap

5121: ibhs-ithiadiaz-bala-betabediox

5122: bhs-oxadiaz-gly-betahc

5123: tolhs-24thiaz-gly-betahmph

5124: bhs-oxadiaz-bala-zdap

5125: bhs-oxadiaz-bala-betahbcph

5126: bim-24thiaz-gly-psdap

5127: bhs-24thiaz-ala-betampy

5128: 2 pmhs-25oxaz-gly-beta35dbph

5129: bhs-26py-gly-betainyl

5130: bhs-nme35pyr-bala-betapym

5131: 2py-26py-met-zdap

5132: ibhs-25oxaz-bala-betacthioph

5133: impy-24thioph-gly-betabthioph

5134: tolhs-oxadiaz-gly-betahdcph

5135: bhs-24thiaz-gly-betapych

5136: bhs-oxadiaz-ala-psdap

5137: phhs-24thiaz-gly-betadcphee

5138: phhs-oxadiaz-gly-betaibph

5139: ibhs-25oxaz-bala-betadhbfu

5140: ibhs-25thiaz-bala-betathiobe

5141: bhs-nme35pyr-ala-betadcph

5142: bhs-25oxaz-bala-betampy

5143: 2py-26py-ala-betainyl

5144: tolhs-25oxaz-bala-beta13bendi

5145: tolhs-nme35pyr-bala-betahmo

5146: bhs-nme35pyr-gly-betadbph

5147: bim-me25thioph-bala-psdap

5148: bhs-25oxaz-ala-beta34dcph

5149: ibhs-nme35pyr-gly-zdaptb

01/283/02 / PB

206

5150: tolhs-25methiaz-bala-betamethi

5151: bhs-nme35pyr-gly-beta13bendi

5152: 2py-me25thioph-leu-psdap

5153: ibhs-24thioph-bala-betatbuph

5154: sabhs-24thiaz-gly-psdap

5155: bhs-25thiaz-bala-betahmph

5156: bim-triaz-gly-betapy

5157: phhs-24thioph-bala-betamethioph

5158: phhs-nme35pyr-bala-psdaptb

5159: dhim-24py-gly-betameph

5160: cima-25thiaz-bala-psdap

5161: bhs-24thiaz-gly-betampy

5162: tolhs-25methiaz-bala-beta23meoph

5163: 2py-ithiadiaz-ala-betapy

5164: impy-25methiaz-gly-betabthioph

5165: ibhs-24thioph-bala-betaoxope

5166: tolhs-me25thiaz-gly-beta34meoph

5167: ibhs-nme35pyr-gly-betamethi

5168: ibhs-nme35pyr-gly-betabpy

5169: tolhs-25methiaz-bala-betaph

5170: tolhs-24thioph-gly-betapyr

5171: ibhs-25oxaz-bala-betahph

5172: bim-24thiaz-bala-betafphe

5173: tolhs-me24thioph-gly-betadcph

5174: bhs-ithiadiaz-gly-psdapch

5175: 2py-24thiaz-bala-betapy

5176: tolhs-nme35pyr-bala-betaipro

5177: bhs-24thioph-nmgly-beta23meoph

5178: bim-52thiaz-gly-betadcph

5179: gua-24oxaz-gly-betathioph

5180: bhs-triaz-gly-betadcph

01/283/02 / PB

207

5181: bim-42nmeim-bala-betaipr

5182: tolhs-25thiaz-gly-betapym

5183: phhs-25thiaz-bala-betadcphch

5184: phhs-ithiadiaz-gly-betafu2

5185: phhs-ithiadiaz-bala-betampy

5186: phhs-ithiadiaz-gly-betadcphtb

5187: dhim-26py-ala-betapy

5188: phhs-oxadiaz-gly-betamesu

5189: ibhs-25methiaz-bala-psdapee

5190: phhs-me24thioph-gly-zdap

5191: ibhs-25oxaz-gly-betadmph

5192: bhs-25methiaz-gly-betadcphee

5193: bim-oxadiaz-ala-psdap

5194: phhs-ithiadiaz-gly-betaamibe

5195: 2py-me25oxaz-gly-betaph

5196: phhs-25oxaz-bala-aspaba

5197: bim-me25oxaz-leu-zdap

5198: 2py-25thiaz-bala-betafluo

5199: ibhs-24thioph-gly-betafphe

5200: bim-25thiaz-bala-betapy

5201: bhs-24thioph-bala-betatos

5202: gua-25thiaz-gly-betabdimo

5203: 2py-42oxaz-ala-betadcph

5204: bhs-ithiadiaz-gly-betamethioph

5205: tolhs-me25thioph-leu-betapy

5206: bhs-25thiaz-ala-psdap

5207: ibhs-25thiaz-bala-betaoxope

5208: bhs-25oxaz-bala-betahmph

5209: bhs-25thiaz-gly-betabthioph

5210: tolhs-24thioph-gly-betabenfu

5211: phhs-me25thioph-leu-betaph

01/283/02 / PB

208

5212: tolhs-25thiaz-gly-ibsdap

5213: phhs-24thioph-gly-betahni

5214: bhs-24thioph-gly-betaipr

5215: tolhs-me25oxaz-ala-betapy

5216: phhs-me24thioph-bala-zdap

5217: bhs-25oxaz-bala-betathioph

5218: ibhs-ithiadiaz-gly-zdaptb

5219: ibhs-24thioph-bala-betahmo

5220: tolhs-25methiaz-gly-betabthioph

5221: tolhs-nme35pyr-gly-betaibph

5222: tolhs-me24thioph-gly-zdap

5223: phhs-24thiaz-gly-ibsdap

5224: tolhs-25thiaz-gly-betahbcph

5225: ibhs-oxadiaz-bala-betafph

5226: bhs-oxadiaz-nmgly-betahmph

5227: impy-42nmeim-bala-betameph

5228: gua-25thiaz-gly-betadcph

5229: phhs-oxadiaz-gly-betapym

5230: bhs-24thioph-gly-betabmph

5231: phhs-24thioph-gly-aspibua

5232: bhs-25oxaz-ala-betahph

5233: ibhs-24thiaz-gly-asppha

5234: 2py-42oxaz-gly-zdap

5235: phhs-me24thiaz-gly-beta34meoph

5236: bhs-nme35pyr-bala-betamethi

5237: bhs-25oxaz-bala-betaheph

5238: dhim-25thiaz-ala-betameph

5239: bhs-ithiadiaz-gly-beta35dbph

5240: bim-oxadiaz-ala-betapy

5241: ibhs-nme35pyr-bala-betafu3

5242: phhs-ithiadiaz-gly-betabpy

01/283/02 / PB

209

5243: tolhs-ithiadiaz-gly-betah35dc

5244: 2py-me25thiaz-ala-psdap

5245: bim-24im-ala-zdap

5246: bim-me25oxaz-gly-beta34meoph

5247: bhs-oxadiaz-bala-betapbiph

5248: bhs-24thioph-gly-beta4bph

5249: ibhs-25methiaz-bala-betaibph

5250: ibhs-24thiaz-gly-betatbuph

5251: bhs-oxadiaz-nmgly-betaanaphth

5252: phhs-25thiaz-gly-betamethi

5253: ibhs-ithiadiaz-gly-betadcphtb

5254: tolhs-24thioph-bala-betaet

5255: bhs-25methiaz-bala-beta34meoph

5256: ibhs-25thiaz-bala-suabu

5257: 2py-42nmeim-gly-betapy

5258: tolhs-25thiaz-bala-betahmph

5259: bhs-25thiaz-gly-betahni

5260: 2 pmhs-42nmeim-bala-betaphethio 5261: tolhs-25methiaz-gly-betadbph

5262: ibhs-25thiaz-gly-betamethioph

5263: bhS 25thiaz-nmala-betameph

5264: 2py-25methiaz-ala-betadcph

5265: bim-35fur-gly-betadcph

5266: bhs-oxadiaz-gly-betabenfu

5267: 2py-oxadiaz-gly-betadcph

5268: bhs-25oxaz-bala-betaph

5269: phhs-24thioph-gly-betamethioph

5270: phhs-oxadiaz-bala-betafu2

5271: bhs-25methiaz-gly-betaoxaz

5272: tolhs-25thiaz-bala-betacbph

5273: tolhs-25oxaz-gly-betah35dc

01/283/02 / PB 210

5274: ibhs-24thiaz-gly-aspaba

5275: bim-25oxaz-bala-aspbzla

5276: tolhs-oxadiaz-bala-betahmofu

5277: bhs-25oxaz-bala-csdap

5278: tolhs-oxadiaz-gly-zdaptb

5279: phhs-25thiaz-bala-beta34dcph

5280: phhs-24thioph-bala-betambiph

5281: tolhs-24thiaz-gly-betabthioph

5282: bhs-24thiaz-bala-betaomebendi

5283: phhs-25thiaz-bala-beta35dbph

5284: ibhs-25methiaz-bala-aspbzla

5285: bhs-24thioph-ala-beta23meoph

5286: bhs-nme35pyr-bala-csdap

5287: phhs-24thiaz-bala-betafu3

5288: ibhs-25methiaz-gly-betaimide

5289: ibhs-24thiaz-gly-betafph

5290: impy-25oxaz-bala-betabenfu

5291: bhs-25thiaz-bala-suabu

5292: phhs-24thioph-gly-betabdimo

5293: tolhs-me24thioph-bala-psdap

5294: ibhs-24thioph-gly-betabenfu

5295: bim-35fur-ala-betapy

5296: bhs-25oxaz-bala-suabu

5297: bhs-25thiaz-bala-betamethi

5298: bhs-oxadiaz-bala-betabpy

5299: gua-24thiaz-gly-betaamibe

5300: bhs-25methiaz-bala-betathioph

5301: phhs-me25thiaz-gly-betadcph

5302: bhs-24thiaz-bala-ibsdap

5303: ibhs-25thiaz-bala-aspaba

5304: tolhs-ithiadiaz-bala-betaheph

01/283/02 / PB

211

5305: bhs-25oxaz-nmgly-betahph

5306: tolhs-24thioph-gly-betaol

5307: bhs-25methiaz-bala-betapych

5308: 2py-42nmeim-bala-betaomebendi

5309: bhs-25methiaz-bala-betabthioph

5310: bhs-25thiaz-bala-betaimide

5311: tolhs-24thiaz-gly-betahb

5312: ibhs-ithiadiaz-bala-betacph

5313: ibhs-25oxaz-gly-asppha

5314: phhs-25thiaz-gly-betahdbph

5315: tolhs-ithiadiaz-gly-betacthioph

5316: bhs-ithiadiaz-ala-beta13bendi

5317: tolhs-25oxaz-gly-betabph

5318: ibhs-25thiaz-bala-betaomebendi

5319: bhs-ithiadiaz-gly-ibsdap

5320: ibhs-24thiaz-gly-betapyee

5321: tolhs-24thioph-bala-betathiobe

5322: bhs-ithiadiaz-gly-betapyee

5323: ibhs-24thioph-gly-betadito

5324: bim-me24oxaz-leu-beta34meoph

5325: tolhs-24thiaz-bala-busu2be

5326: bhs-25thiaz-gly-betaoxaz

5327: ibhs-nme35pyr-gly-aspaba

5328: ibhs-nme35pyr-bala-betatrif

5329: bhs-25oxaz-bala-betafph

5330: tolhs-25oxaz-bala-betacbph

5331: 2py-oxadiaz-ala-betadcph

5332: phhs-24thiaz-bala-busu2be

5333: tolhs-25methiaz-gly-betainyl

5334: phhs-nme35pyr-bala-betafu3

5335: bhs-24thiaz-gly-betaphethioa

212

01/283/02 / PB

5336: ibhs-25oxaz-gly-aspibua

5337: tolhs-24thiaz-gly-betaphethioa

5338: 2py-25methiaz-gly-beta35dbph

5339: ibhs-nme35pyr-gly-betahb

5340: 2py-25thiaz-bala-betadcph

5341: 2py-me24thioph-leu-zdap

5342: phhs-nme35pyr-gly-betaipr

5343: bhs-25oxaz-nmgly-betacph

5344: tolhs-oxadiaz-bala-beta4bph

5345: bhs-24thioph-ala-betadcph

5346: phhs-25thiaz-gly-beta13bendi

5347: tolhs-oxadiaz-gly-suabu

5348: bhs-25oxaz-bala-betapyee

5349: tolhs-25thiaz-bala-aspbzla

5350: tolhs-24thiaz-gly-betahcbph

5351: ibhs-oxadiaz-bala-betatrif

5352: bhs-24thiaz-bala-zdap

5353: ibhs-ithiadiaz-bala-betapyee

5354: 2py-42nmeim-leu-betadcph

5355: bim-42pym-gly-betameph

5356: tolhs-25oxaz-gly-betafph

5357: phhs-25oxaz-bala-betahmo

5358: bhs-25thioph-ala-betainyl

5359: phhs-25methiaz-gly-betaftrif

5360: bim-25oxaz-bala-betapy

5361: ibhs-nme35pyr-gly-betaol

5362: 2py-25methiaz-gly-betatbuph

5363: bhs-25thiaz-bala-betadmoph

5364: tolhs-24thioph-bala-csdap

5365: ibhs-oxadiaz-gly-beta13bendi

5366: tolhs-nme35pyr-gly-betampy

01/283/02 / PB

213

5367: bhs-25oxaz-bala-betaoxaz

5368: bhs-nme35pyr-nmgly-betafphe

5369: tolhs-nme35pyr-bala-betadcph

5370: tolhs-nme35pyr-bala-betadmoph

5371: 2py-25thiaz-gly-betapy

5372: dhim-42pym-ala-betameph

5373: bhs-24thiaz-bala-betapy

5374: phhs-oxadiaz-bala-betaimide

5375: ibhs-ithiadiaz-gly-betahmph

5376: tolhs-24thioph-bala-zdapch

5377: 2py-24oxaz-ala-psdap

5378: ibhs-ithiadiaz-gly-betambiph

5379: bim-nme35pyr-bala-psdap

5380: bim-25fur-leu-betadcph

5381: bhs-oxadiaz-bala-psdap

5382: phhs-25methiaz-bala-betaipr

5383: bhs-me25thiaz-ala-zdap

5384: ibhs-ithiadiaz-bala-betameph

5385: bhs-25oxaz-gly-beta13bendi

5386: tolhs-nme35pyr-bala-betabdimo

5387: ibhs-oxadiaz-bala-betahc

5388: bhs-25oxaz-bala-beta34dcph

5389: ibhs-25thiaz-bala-betadhbfu

5390: bhs-25methiaz-gly-betatrif

5391: ibhs-24thiaz-bala-betafu2

5392: phhs-ithiadiaz-gly-betabediox

5393: bhs-me25thioph-gly-betapy

5394: bhs-me25oxaz-ala-betadcph

5395: bhs-24thiaz-gly-betaphethio

5396: tolhs-24thiaz-bala-betadtrif

5397: bhs-ithiadiaz-nmgly-betaanaphth

01/283/02 / PB

214

5398: phhs-24thiaz-bala-betadcphtb

5399: bhs-ithiadiaz-ala-betacph

5400: thpym-24thioph-bala-psdap

5401: bhs-25oxaz-ala-betathioph

5402: bim-25methiaz-nmala-betadcph

5403: tolhs-25methiaz-gly-betahc

5404: bhs-25py-gly-betapy

5405: bim-me24thiaz-leu-zdap

5406: ibhs-oxadiaz-bala-betapyee

5407: phhs-me25oxaz-bala-betaph

5408: phhs-ithiadiaz-bala-betahmofu

5409: ibhs-25oxaz-bala-betafbph

5410: phhs-ithiadiaz-gly-betabmph

5411: phhs-25thiaz-gly-betabthioph

5412: ibhs-25methiaz-gly-aspibua

5413: tolhs-25thiaz-gly-psdapee

5414: bim-25thioph-ala-psdap

5415: bhs-ithiadiaz-nmgly-beta23meoph

5416: bhs-24thiaz-gly-betahb

5417: tolhs-25thiaz-gly-betamethi

5418: tolhs-oxadiaz-bala-betapych

5419: bim-25methiaz-ala-psdap

5420: bhs-me24oxaz-leu-betapy

5421: tolhs-25methiaz-gly-beta4bph

5422: dhim-26py-gly-betapy

5423: ibhs-oxadiaz-gly-asppha

5424: 2py-24thiaz-leu-betadcph

5425: tolhs-oxadiaz-bala-betabmph

5426: bhs-oxadiaz-bala-betafu2

5427: bhs-25methiaz-bala-betaipro

5428: tolhs-25methiaz-gly-betapych

215

01/283/02 / PB

5429: phhs-25thiaz-bala-beta4bph

5430: bim-thiadiaz-leu-betadcph

5431: tolhs-24thiaz-gly-betabmph

5432: gua-42pym-gly-betaheph

5433: phhs-ithiadiaz-bala-betaipr

5434: 2 pmhs-25thiaz-bala-betapyr

5435: tolhs-me24thioph-leu-betadcph

5436: bhs-oxadiaz-gly-betamethi

5437: phhs-24thiaz-bala-betathiome

5438: ibhs-nme35pyr-bala-betamethioph

5439: tolhs-me24thiaz-ala-psdap

5440: tolhs-24thioph-gly-betadito

5441: bhs-24thiaz-bala-betahdcph

5442: phhs-24thiaz-gly-betathiobe

5443: bim-42pym-ala-betameph

5444: phhs-24thiaz-gly-zdaptb

5445: bhs-24thiaz-gly-csdap

5446: bhs-oxadiaz-bala-betadtrif

5447: 2py-42oxaz-ala-psdap

5448: phhs-oxadiaz-bala-beta4bph

5449: bhs-oxadiaz-gly-betahdbph

5450: gua-26py-gly-beta4bph

5451: bhs-26pyrazi-ala-betapy

5452: tolhs-24thiaz-gly-psdaptb

5453: bhs-42nmeim-gly-betaheph

5454: ibhs-ithiadiaz-bala-betatbuph

5455: ibhs-24thioph-bala-betatrif

5456: phhs-25methiaz-gly-betaph

5457: bim-me24thioph-bala-zdap

5458: ibhs-oxadiaz-bala-betabthioph

5459: bhs-me24oxaz-leu-psdap

216

01/283/02 / PB

5460: tolhs-24thiaz-gly-betapych

5461: phhs-25thiaz-gly-betaol

5462: bhs-me24im-gly-zdap

5463: bim-25oxaz-gly-betathiome

5464: impy-25oxaz-bala-betaamibe

5465: tolhs-25methiaz-bala-asppha

5466: ibhs-24thioph-bala-betahdcph

5467: ibhs-25methiaz-bala-busii2be

5468: bhs-24thiaz-bala-betabmph

5469: bhs-me25thioph-gly-psdap

5470: ibhs-24thiaz-bala-betafluo

5471: dhim-24thiaz-ala-betapy

5472: bim-25thioph-leu-betadcph

5473: thpym-24thiaz-bala-psdap

5474: bhs-25oxaz-bala-betameph

5475: bhs-24thiaz-gly-betaoxaz

5476: bim-24thiaz-ala-psdap

5477: phhs-24thiaz-bala-betaoxaz

5478: bhs-ithiadiaz-bala-betahb

5479: bhs-ithiadiaz-bala-zdapee

5480: bhs-25oxaz-nmgly-betaoxaz

5481: bhs-25thiaz-nmgly-betadito

5482: bhs-nme35pyr-gly-psdapch

5483: ibhs-nme35pyr-gly-betadbph

5484: phhs-me24oxaz-leu-zdap

5485: bhs-oxadiaz-bala-betaoxaz

5486: bhs-oxadiaz-gly-betadito

5487: gua-42pym-gly-betathiobe

5488: bim-42nmeim-ala-betadcph

5489: bhs-42nmeim-gly-betabnaphth

5490: phhs-ithiadiaz-bala-betapytb

01/283/02 / PB

5491: 2py-ithiadiaz-bala-aspbzla

5492: bhs-24thioph-gly-betafbph

5493: bhs-oxadiaz-bala-betaanaphth

5494: bhs-me24oxaz-bala-betaph

5495: phhs-25thiaz-bala-betacthioph

5496: tolhs-25methiaz-bala-betapyee

5497: bhs-25methiaz-gly-beta35dbph

5498: phhs-me24oxaz-gly-betapy

5499: ibhs-25methiaz-bala-betaph

5500: 2py-24oxaz-bala-betapy

5501: ibhs-ithiadiaz-gly-aspibua

5502: phhs-25thiaz-gly-betadcphee

5503: bhs-24pym-gly-zdap

5504: tolhs-24thiaz-gly-betathioph

5505: tolhs-ithiadiaz-bala-betadcphch

5506: 2py-ithiadiaz-leu-betadcph

5507: phhs-24thiaz-bala-betapyee

5508: phhs-ithiadiaz-bala-betadcph

5509: bhs-25oxaz-bala-betamethioph

5510: 2py-53pyrazo-leu-betapy

5511: ibhs-25oxaz-gly-betadcph

5512: ibhs-oxadiaz-gly-csdap

5513: bim-25methiaz-ala-betadcph

5514: phhs-25methiaz-bala-betamethioph

5515: bhs-oxadiaz-bala-psdaptb

5516: 2py-me25thiaz-gly-betapy

5517: tolhs-25thiaz-gly-betacph

5518: impy-42nmeim-gly-betapyr

5519: bim-25methiaz-bala-betafphe

5520: phhs-25oxaz-gly-betapytb

5521: ibhs-25oxaz-gly-betapbiph

217

01/283/02 / PB

218

5522: 2py-me25oxaz-bala-psdap

5523: bhs-ithiadiaz-bala-zdaptb

5524: 2py-25methiaz-bala-betafluo

5525: bhs-25thiaz-gly-betacthioph

5526: bhs-nme35pyr-bala-beta35dbph

5527: bhs-25oxaz-bala-betadcph

5528: tolhs-25thiaz-gly-betahdbph

5529: phhs-25thiaz-bala-betafph

5530: bhs-25thiaz-bala-betahdcph

5531: bhs-ithiadiaz-gly-betafu3

5532: bhs-25thiaz-bala-betapym

5533: bhs-ithiadiaz-ala-beta23meoph

5534: ibhs-nme35pyr-bala-betapych

5535: bhs-me25oxaz-bala-betapy

5536: 2py-nme35pyr-bala-asppha

5537: 2py-35thioph-bala-betapy

5538: phhs-nme35pyr-bala-betadcphee

5539: tolhs-25oxaz-bala-betabpy

5540: bhs-24thioph-bala-betacthioph

5541: bhs-24thioph-ala-betabpy

5542: bim-24im-leu-betadcph

5543: bhs-oxadiaz-gly-betamesu

5544: bhs-thiadiaz-gly-betadcph

5545: tolhs-25thiaz-bala-betameph

5546: bhs-thiadiaz-ala-psdap

5547: bhs-24thioph-bala-betadcphch

5548: bhs-ithiadiaz-gly-betabenfu

5549: ibhs-nme35pyr-bala-betadcphee

5550: bhs-me25oxaz-leu-betaph

5551: bhs-me24thiaz-leu-betadcph

5552: tolhs-25thiaz-gly-betatbuph

01/283/02 / PB

219

5553: gua-25thioph-gly-betacbph

5554: phhs-25methiaz-gly-betahph

5555: 2py-me25thiaz-bala-psdap

5556: bhs-25methiaz-nmgly-betabpy

5557: bhs-oxadiaz-nmgly-betameph

5558: tolhs-24thiaz-gly-betacthioph

5559: dimethpyin-24thioph-gly-betameph

5560: ibhs-25oxaz-bala-betameph

5561: bhs-24thioph-bala-aspbzla

5562: ibhs-24thioph-bala-betabediox

5563: tolhs-25oxaz-bala-betaphethioa

5564: ibhs-24thiaz-gly-betabpy

5565: tolhs-25oxaz-bala-betacthioph

5566: tolhs-24thioph-bala-betapbiph

5567: ibhs-oxadiaz-bala-betahbcph

5568: phhs-oxadiaz-bala-betatrif

5569: bhs-25oxaz-bala-betabmph

5570: ibhs-oxadiaz-gly-betameph

5571: phhs-ithiadiaz-bala-betathiome

5572: tolhs-ithiadiaz-bala-betacthioph

5573: phhs-24thiaz-bala-betaftrif

5574: ibhs-ithiadiaz-bala-betamethi

5575: ibhs-ithiadiaz-gly-betabenfu

5576: ibhs-24thioph-gly-betahdcph

5577: phhs-me25thioph-bala-betaph

5578: 2py-oxadiaz-gly-aspbzla

5579: bhs-24thiaz-nmgly-betameph

5580: tolhs-oxadiaz-bala-betadtrif

5581: bhs-oxadiaz-bala-beta3quin

5582: hs-25thioph-gly-betapy

5583: 2py-53pyrazo-gly-betapy

01/283/02 / PB

220

5584: bhs-me25thiaz-leu-beta34meoph

5585: bgua-25thiaz-gly-betapy

5586: tolhs-nme35pyr-gly-betahni

5587: tolhs-25thiaz-gly-betafphe

5588: bhs-ithiadiaz-bala-csdap

5589: dhim-24thiaz-gly-betadtrif

5590: bim-24thiaz-bala-aspaba

5591: phhs-25thiaz-bala-betaheph

5592: bhs-24thiaz-gly-beta13bendi

5593: ibhs-25oxaz-bala-betathioph

5594: phhs-25methiaz-gly-betafu3

5595: tolhs-ithiadiaz-gly-betamethioph

5596: 2py-42nmeim-gly-betatos

5597: ibhs-25oxaz-bala-betapyr

5598: ibhs-nme35pyr-bala-betamethi

5599: bhs-24thioph-bala-betaheph

5600: ibhs-24thiaz-bala-betadcphtb

5601: phhs-25thiaz-gly-betaheph

5602: ibhs-nme35pyr-bala-betaphethio

5603: ibhs-25methiaz-gly-betathio3

5604: tolhs-nme35pyr-gly-betaol

5605: tolhs-24thioph-gly-suabu

5606: bhs-25oxaz-gly-beta35dbph

5607: tolhs-24thiaz-gly-aspbzla

5608: bhs-24thioph-nmgly-betameph

5609: tolhs-ithiadiaz-bala-betahni

5610: bhs-25oxaz-gly-busu2be

5611: phhs-me25thioph-gly-beta34meoph

5612: bhs-24thiaz-gly-betadcphtb

5613: bim-26py-gly-betapy

5614: 2py-me24thiaz-ala-betaph

01/283/02 / PB

221

5615: 2py-me24oxaz-bala-betadcph 5616: bhs-25methiaz-gly-betahni 5617: bhs-25methiaz-gly-betabph 5618: bhs-24thiaz-bala-betafphe 5619: tolhs-ithiadiaz-bala-betafbph 5620: ibhs-oxaf -gly-betahc 5621: phhs-nme35pyr-baia-betabmph 5622: bhs-25methiaz-bala-betaimide 5623: tolhs-oxadiaz-bala-betadbph 5624: bhs-25methiaz-gly-beta34dcph 5625: bhs-ithiadiaz-56g: 26 : bhs-25methiaz-gly-zdap 5627: gua-25thioph-gly-beta13bendi 5628: phhs-24thiaz-bala-betaibph 5629: bhs-24thioph-bala-betamethi 5630: bim-me24oxaz-ala-betapy 5631: phhs-24thioph- bala-betahmo 5632: ibhs-24thioph-gly-betahmo 5633: tolhs-oxadiaz-bala-betafph 5634: ibhs-25oxaz-gly-betafluo 5635: phhs-25thiaz-gly-betaipro 5636: 2py-thiadiaz-ala-zdap 5637: tolhs-ithiadiaz-gly-betadcphtb 5638: ibhs-25thiaz-bala-betahb 5639: phhs-me24thioph-gly-betaph 5640: phhs-oxadiaz-gly-betapy 5641: tolhs-nme35pyr-gly-betathio3 5642: bhs-25methiaz -betafphe 5643: bhs-nme35pyr-bala-betatrif 5644: phhs-nme35pyr-bala-betaheph 5645: bim-25thiaz -bala-asppha

umm

01/283/02 / PB

222

5646: 2py-25thiaz-bala-beta34dcph

5647: bhs-24thiaz-gly-suabii

5648: ibhs-24thioph-bala-betafbph

5649: tolhs-25thiaz-bala-zdapee

5650: tolhs-ithiadiaz-bala-ibsdap

5651: bhs-25methiaz-gly-betaphethio

5652: ibhs-25oxaz-gly-betapym

5653: phhs-25oxaz-bala-betahb

5654: ibhs-ithiadiaz-gly-betainyl

5655: tolhs-me24thiaz-leu-psdap

5656: ibhs-25oxaz-bala-betathio3

5657: 2py-53pyrazo-leu-psdap

5658: tolhs-nme35pyr-bala-betacph

5659: ibhs-25thiaz-bala-betafu2

5660: ibhs-25methiaz-gly-betadcphch

5661: bhs-me24oxaz-ala-zdap

5662: phhs-24thiaz-bala-beta34meoph

5663: tolhs-nme35pyr-bala-betathiobe

5664: phhs-me24thioph-gly-psdap

5665: tolhs-25oxaz-gly-betabpy

5666: 2py-25oxaz-gly-asppha

5667: ibhs-25methiaz-gly-betacbph

5668: bhs-25methiaz-bala-beta3quin

5669: tolhs-24thioph-gly-beta23meoph

5670: tolhs-nme35pyr-gly-betahcbph

5671: ibhs-25thiaz-bala-betaphethioa

5672: phhs-nme35pyr-gly-betafphe

5673: bhs-ithiadiaz-gly-betabediox

5674: ibhs-24thiaz-gly-betahdbph

5675: tolhs-25methiaz-bala-betathioph

5676: tolhs-nme35pyr-bala-betamethi

01/283/02 / PB

223

5677: tolhs-25thiaz-gly-betabenfu

5678: gua-24thiaz-gly-betabdimo

5679: phhs-24thiaz-bala-psdapee

5680: phhs-oxadiaz-gly-psdapch

5681: phhs-25oxaz-gly-betahdcph

5682: ibhs-24thioph-bala-betapym

5683: tolhs-25thiaz-gly-betahb

5684: bhs-42nmeim-gly-betaet

5685: bim-me25thioph-ala-betapy

5686: bim-25thiaz-leu-betadcph

5687: bhs-25thiaz-bala-betapyee

5688: ibhs-25methiaz-bala-betahmo

5689: phhs-25oxaz-gly-betacbph

5690: dhim-42pym-ala-zdap

5691: bhs-oxadiaz-gly-betathioph

5692: tolhs-25oxaz-gly-betahmo

5693: phhs-24thiaz-gly-betaipr

5694: tolhs-me24oxaz-leu-betapy

5695: phhs-oxadiaz-gly-betapytb

5696: ibhs-25methiaz-gly-beta35dbph

5697: bhs-ithiadiaz-gly-betadhbfu

5698: phhs-25thiaz-gly-busu2be

5699: bhs-nme35pyr-bala-betambiph

5700: bim-24thioph-gly-betapy

5701: ibhs-nme35pyr-gly-betadcphtb

5702: bim-25methiaz-gly-psdap

5703: phhs-nme35pyr-bala-betaipr

5704: gua-25thiaz-gly-betainyl

5705: bhs-25oxaz-bala-betafluo

5706: gua-25thioph-gly-betahmph

5707: tolhs-24thioph-gly-betainyl

v

01/283/02 / PB

224

5708: bhs-24thioph-bala-betaet

5709: tolhs-25oxaz-bala-betafu3

5710: 2py-24thiaz-bala-beta34dcph

5711: gua-42pym-gly-betaph

5712: tolhs-ithiadiaz-gly-betahni

5713: 2py-42nmeim-leii-psdap

5714: 2py-24thiaz-hphe-psdap

5715: phhs-nme35pyr-gly-zdapee

5716: bhs-26py-ala-betapy

5717: ibhs-25methiaz-gly-betabph

5718: bhs-25methiaz-bala-betaphethioa

5719: tolhs-me25thiaz-ala-zdap

5720: bhs-24thioph-bala-beta3quin

5721: dhim-25thioph-ala-betainyl

5722: phhs-oxadiaz-gly-betahph

5723: tolhs-25oxaz-gly-betatbuph

5724: bhs-oxadiaz-gly-betaphethio

5725: bim-me24oxaz-ala-betaph

5726: tolhs-me25thiaz-leu-beta34meoph

5727: bim-24im-bala-betapy

5728: phhs-ithiadiaz-bala-betahb

5729: tolhs-25methiaz-gly-beta35dbph

5730: ibhs-25thiaz-bala-betadcphee

5731: ibhs-oxadiaz-bala-beta23meoph

5732: gua-24oxaz-gly-betatrif

5733: 2py-25thioph-ala-zdap

5734: bhs-42oxaz-leu-betadcph

5735: bhs-triaz-bala-betapy

5736: phhs-25methiaz-bala-beta34dcph

5737: tolhs-ithiadiaz-gly-betabediox

5738: phhs-oxadiaz-bala-beta13bendi

01/283/02 / PB

225

5739: ibhs-25thiaz-bala-betahmo

5740: tolhs-25methiaz-bala-betadhbfu

5741: 2py-me24oxaz-leu-betapy

5742: phhs-ithiadiaz-bala-betafluo

5743: tolhs-24thioph-bala-betathiome

5744: bhs-52thiaz-gly-psdap

5745: tolhs-oxadiaz-gly-betabediox

5746: bhs-ithiadiaz-ala-betabnaphth

5747: phhs-oxadiaz-bala-betaamibe

5748: ibhs-oxadiaz-bala-betadcphch

5749: phhs-24thioph-bala-betafu2

5750: bhs-itbiadiaz-bala-betaoxope

5751: phhs-25oxaz-gly-betaoxaz

5752: ibhs-oxadiaz-bala-betaphethio

5753: bhs-25methiaz-nmgly-beta34meoph

5754: bhs-nme35pyr-gly-betadcph

5755: 2py-24oxaz-gly-betapy

5756: tolhs-25thiaz-bala-psdapch

5757: bhs-25thiaz-bala-betaoxaz

5758: bhs-24oxaz-gly-betameph

5759: bhs-24thioph-ala-betathioph

5760: ibhs-25oxaz-bala-betaipro

5761: phhs-ithiadiaz-bala-betambiph

5762: phhs-24thioph-bala-betaibph

5763: ibhs-ithiadiaz-bala-betadito

5764: tolhs-ithiadiaz-bala-betadcphee

5765: tolhs-oxadiaz-gly-aspbzla

5766: phhs-nme35pyr-gly-betaoxaz

5767: bhs-42nmeim-gly-beta34dcph

5768: ibhs-oxadiaz-gly-betadito

5769: bhs-nme35pyr-gly-betahbcph

01/283/02 / PB

226

5770: tolhs-24thioph-bala-betamethioph

5771: bhs-25methiaz-gly-beta23meoph

5772: bhs-25methiaz-ala-betahmph

5773: ibhs-25methiaz-bala-betadcphtb

5774: tolhs-24thioph-gly-betadbph

5775: tolhs-ithiadiaz-bala-betaet

5776: ibhs-ithiadiaz-gly-betaSquin

5777: 2 pmhs-42nmeim-met-betapy

5778: ibhs-24thioph-gly-betafph

5779: ibhs-ithiadiaz-gly-betadbph

5780: phhs-25thiaz-bala-beta34meoph

5781: phhs-25oxaz-bala-betamesu

5782: bim-24thiaz-bala-betampy

5783: ibhs-25methiaz-bala-beta34meoph

5784: phhs-oxadiaz-gly-aspibua

5785: 2py-me24oxaz-bala-betaph

5786: bhs-24im-leu-betapy

5787: ibhs-25thiaz-gly-betampy

5788: 2py-me24thiaz-gly-beta34meoph

5789: ibhs-25methiaz-bala-zdaptb

5790: gua-42pym-gly-betapym

5791: phhs-nme35pyr-bala-psdapee

5792: phhs-oxadiaz-bala-betahph

5793: bhs-35fur-bala-zdap

5794: tolhs-25thiaz-bala-psdaptb

5795: tolhs-25thiaz-gly-betabph

5796: phhs-24thioph-bala-betaftrif

5797: ibhs-oxadiaz-gly-betamethi

5798: phhs-oxadiaz-bala-ibsdap

5799: ibhs-24thioph-bala-aspbzla

5800: bim-me25thioph-ala-betadcph

01/283/02 / PB

227

5801: bhs-24pym-ala-betameph

5802: phhs-me25oxaz-ala-psdap

5803: tolhs-24thioph-bala-betacthioph

5804: 2py-24thiaz-gly-betadcph

5805: phhs-25thiaz-bala-betadtrif

5806: phhs-me25thioph-leu-zdap

5807: bhs-42nmeim-bala-zdap

5808: ibhs-oxadiaz-gly-betadmph

5809: phhs-25oxaz-bala-aspibua

5810: bim-thiadiaz-gly-betapy

5811: tolhs-25methiaz-gly-betadcphch

5812: ibhs-nme35pyr-bala-betahcbph

5813: bhs-25methiaz-bala-suabu

5814: tolhs-25oxaz-bala-betadbph

5815: phhs-ithiadiaz-gly-betaoxaz

5816: bhs-nme35pyr-bala-asppha

5817: tolhs-24thioph-gly-betahb

5818: bim-me25thioph-ala-psdap

5819: gua-24oxaz-gly-zdap

5820: phhs-25thiaz-gly-betabdimo

5821: phhs-25thiaz-gly-aspaba

5822: bhs-53pyrazo-bala-psdap

5823: 2py-42nmeim-leu-zdap

5824: phhs-oxadiaz-gly-betadcphee

5825: imhs-25thiaz-gly-zdap

5826: phhs-25thiaz-bala-aspaba

5827: phhs-25methiaz-gly-betadhbfu

5828: bhs-24thiaz-bala-beta34meoph

5829: bhs-24thiaz-gly-betahmph

5830: 2py-me25oxaz-bala-betaph

5831: hyd-42nmeim-bala-betadcph

01/283/02 / PB

5832: bhs-25thiaz-bala-beta3quin

5833: ibhs-ithiadiaz-bala-betabph

5834: ibhs-24thiaz-gly-betapbiph

5835: 2py-25methiaz-bala-betadcph

5836: 2py-25oxaz-leu-psdap

5837: tolhs-oxadiaz-gly-psdapch

5838: bhs-24thioph-ala-zdap

5839: bhs-24thioph-bala-betapych

5840: phhs-25thiaz-bala-betadcph

5841: bgua-42pym-gly-betapy

5842: bhs-25methiaz-nmgly-betacph

5843: impy-25oxaz-bala-betafbph

5844: phhs-24thiaz-gly-betadcphch

5845: phhs-25methiaz-bala-betaimide

5846: ibhs-25methiaz-bala-betahmofu

5847: ibhs-24thiaz-bala-betafbph

5848: ibhs-24thiaz-gly-busu2be

5849: 2py-24thioph-hphe-psdap

5850: 2py-me24thiaz-leu-beta34meoph

5851: phhs-24thiaz-gly-betaet

5852: phhs-25thiaz-gly-betameph

5853: ibhs-25methiaz-bala-betathiome

5854: tolhs-oxadiaz-bala-betacph

5855: ibhs-nme35pyr-gly-psdaptb

5856: bim-oxadiaz-bala-aspaba

5857: bim-24oxaz-gly-betainyl

5858: bhs-nme35pyr-gly-betaimide

5859: ibhs-25thiaz-bala-betahph

5860: 2py-25thiaz-gly-betameph

5861: phhs-24thioph-gly-busu2be

5862: tolhs-25oxaz-gly-betaol

228

01/283/02 / PB

229

5863: bhs-24thioph-ala-betafphe

5864: bhs-25thiaz-nmgly-betadmoph

5865: ibhs-oxadiaz-bala-aspbzla

5866: bhs-ithiadiaz-bala-betacbph

5867: bim-35fur-ala-psdap

5868: tolhs-25thiaz-gly-betathiome

5869: tolhs-nme35pyr-gly-betahmofu

5870: ibhs-25methiaz-gly-betaibph

5871: tolhs-25thiaz-bala-betapytb

5872: impy-25oxaz-gly-betaphethio

5873: gua-24oxaz-gly-betabthioph

5874: gua-24thiaz-gly-betahcbph

5875: tolhs-nme35pyr-gly-betapym

5876: bim-me24thiaz-leu-betaph

5877: pahs-24thioph-bala-betameph

5878: bim-25thiaz-gly-betahmph

5879: bhs-25thiaz-gly-betabediox

5880: bhs-24thiaz-gly-betathiobe

5881: gua-42pym-nmgly-betapy

5882: gua-24thiaz-gly-betaipr

5883: tolhs-25thiaz-bala-psdap

5884: gua-24thiaz-gly-busu2be

5885: bhs-24thiaz-ala-betaoxaz

5886: tolhs-oxadiaz-bala-betabpy

5887: bhs-24thiaz-gly-betapbiph

5888: bhs-me24oxaz-gly-beta34meoph

5889: bhs-24thioph-bala-betaoxaz

5890: tolhs-ithiadiaz-gly-betahmph

5891: phhs-25methiaz-bala-biisu2be

5892: bhs-24im-leu-zdap

5893: bhs-24thioph-bala-betabpy

01/283/02 / PB

230

5894: bhs-25methiaz-bala ~ betabpy

5895: ihhs-25oxaz-bala-betadcphtb

5896: bhs-25methiaz-gly-ibsdap

5897: phhs-24thiaz-bala-betathioph

5898: phhs-25methiaz-bala-zdap

5899: ibhs-25oxaz-gly-betaamibe

5900: imhs-24thioph-gly-zdap

5901: phhs-oxadiaz-gly-betafluo

5902: 2py-26py-ala-betadcph

5903: 2py-me25thioph-leu-betaph

5904: tolhs-25methiaz-gly-betaoxope

5905: phhs-ithiadiaz-bala-betaol

5906: tolhs-24thiaz-gly-betadtrif

5907: bhs-25methiaz-gly-psdapee

5908: bhs-ithiadiaz-gly-beta23meoph

5909: bhs-me24thiaz-gly-zdap

5910: 2 pmhs-25methiaz-gly-betafph

5911: bhs-25oxaz-bala-betadtrif

5912: bhs-25methiaz-bala-betatos

5913: bim-24thioph-bala-psdap

5914: tolhs-nme35pyr-bala-betafbph

5915: tolhs-24thiaz-bala-aspaba

5916: 2py-triaz-gly-betadcph

5917: ibhs-24thiaz-gly-betahph

5918: tolhs-nme35pyr-gly-beta4bph

5919: tolhs-ithiadiaz-bala-beta4bph

5920: phhs-25oxaz-gly-betadcph

5921: phhs-25methiaz-bala-betadmoph

5922: phhs-oxadiaz-gly-csdap

5923: tolhs-oxadiaz-bala-betadmph

5924: impy-42nmeim-bala-betahbcph

01/283/02 / PB

231

5925: tolhs-24thioph-gly-csdap

5926: ibhs-24thioph-bala-betabmph

5927: bhs-ithiadiaz-bala-betapyr

5928: tolhs-25thiaz-gly-betathiobe

5929: bhs-nme35pyr-bala-betabpy

5930: phhs-oxadiaz-gly-betadmph

5931: tolhs-24thiaz-bala-betadcphch

5932: dhim-25thioph-ala-betameph

5933: bhs-24thioph-bala-betaomebendi

5934: phhs-25oxaz-bala-betadmph

5935: bim-me24oxaz-leu-betapy

5936: bhs-oxadiaz-gly-betainyl

5937: tolhs-oxadiaz-gly-betaanaphth

5938: tolhs-24thioph-bala-betabph

5939: phhs-25thiaz-bala-betambiph

5940: bhs-me25oxaz-bala-zdap

5941: 2 pmhs-25oxaz-bala-betaet

5942: phhs-24thioph-gly-betahph

5943: bhs-oxadiaz-gly-betadtrif

5944: 2py-oxadiaz-leu-betapy

5945: bhs-nme35pyr-bala-betaheph

5946: bim-25fur-gly-betapy

5947: bhs-25methiaz-gly-betaoxope

5948: tolhs-25oxaz-gly-betatrif

5949: dhthi-25oxaz-gly-zdap

5950: bhs-oxadiaz-nmgly-beta23meoph

5951: tolhs-25oxaz-gly-betaibph

5952: phhs-24thiaz-bala-betaanaphth

5953: bim-24thiaz-bala-betacph

5954: 2py-42nmeim-bala-betadcph

5955: ibhs-25thiaz-gly-psdapee

01/283/02 / PB

232

5956: bhs-ithiadiaz-nmgly-beta3quin

5957: tolhs-24thioph-gly-betaheph

5958: bhs-ithiadiaz-ala-beta34meoph

5959: phhs-25oxaz-bala-csdap

5960: tolhs-ithiadiaz-gly-betabenfu

5961: ibhs-ithiadiaz-gly-betafu3

5962: bhs-26py-ala-betainyl

5963: bim-me25thioph-ala-zdap

5964: phhs-nme35pyr-bala-aspibua

5965: phhs-ithiadiaz-bala-zdap

5966: ibhs-oxadiaz-bala-betadcphee

5967: tolhs-oxadiaz-gly-betathioph

5968: impy-25methiaz-bala-busu2be

5969: bhs-ithiadiaz-bala-suabu

5970: bhs-nme35pyr-nmgly-betacthioph

5971: bhs-35fur-bala-psdap

5972: bhs-24thiaz-bala-betaftrif

5973: bhs-25oxaz-gly-betafbph

5974: tolhs-25thiaz-gly-betaibph

5975: 2py-me24thiaz-gly-betadcph

5976: 2py-me24oxaz-bala-psdap

5977: bim-ithiadiaz-ala-betadcph

5978: 2py-25thiaz-gly-betaol

5979: phhs-25oxaz-bala-zdapee

5980: tolhs-25thiaz-bala-beta23meoph

5981: bhs-25thiaz-gly-betahbcph

5982: ibhs-oxadiaz-gly-betahmofu

5983: ibhs-ithiadiaz-gly-betahbcph

5984: 2py-25thiaz-bala-betahni

5985: tolhs-24thiaz-bala-betaipr

5986: 2py-25thioph-ala-betapy

01/283/02 / PB

233

5987: ibhs-oxadiaz-gly-betabthioph 5988: ibhs-25methiaz-gly-betapym 5989: 2py-24thiaz-bala-betadcph 5990: phhs-me25thioph-leu-betadcph 5991: ibhs-24thioph-gly-betainyl 5992: phhs -bala-betatbuph 5993: tolhs-oxadiaz-bala-psdaptb 5994: dhim-24oxaz-ala-betapy 5995: ibhs-25methiaz-bala-betafluo 5996: gua-26py-gly-betahph 5997: phhs-25thiaz-bala-psdapee 5998 : phhs-24thiaz-gly-betaol 5999: bhs-25methiaz-bala-betaol 6000: 2py-nme35pyr-gly-aspibua 6001: ibhs-25oxaz-gly-beta35dbph 6002: tolhs-nme35pyr-gly-betahb 6003: ibhs-nme35pyr- gly-betaheph 6004: bhs-25oxaz-nmgly-betamesu 6005: 2py-24oxaz-ala-betadcph 6006: ibhs-ithiadiaz-gly-betaamibe 6007: tolhs-24thioph-gly-betadcphee 6008: tolhs-25thiaz-bala-asppha 6009 bhs-24thioph-bala-betadhbfu 6010: ibhs-ithiadiaz-bala-betadbph 6011: phhs-oxadiaz-gly-betathio3 6012: bhs-nme35pyr-nmgly-ibsdap 6013: ibhs-24thiaz-gly-betamethioph-oxamethioph-oxamethiophaz-bis-oxamethiophaz: -betathio3 6015: 2py-25oxaz-nmgly-betadcph 6016: 2py-42nmeim-gly-betahcbph 6017: tolhs-24thio ph-gly-betahdbph

01/283/02 / PB

234

6018: ibhs-nme35pyr-gly-betahdbph

6019: ibhs-24thiaz-gly-betabthioph

6020: bhs-25oxaz-bala-betapym

6021: ibhs-25methiaz-bala-betadito

6022: bhs-25thiaz-gly-betapbiph

6023: bhs-ithiadiaz-gly-betaibph

6024: ibhs-24thiaz-gly-betahni

6025: phhs-25oxaz-bala-betameph

6026: 2py-ithiadiaz-gly-aspbzla

6027: bhs-25methiaz-gly-betathiome

6028: phhs-ithiadiaz-gly-betahdcph

6029: tolhs-nme35pyr-bala-betaheph

6030: tolhs-25thiaz-bala-betabph

6031: phhs-nme35pyr-bala-betatos

6032: phhs-me25thiaz-gly-beta34meoph

6033: tolhs-25methiaz-gly-betatrif

6034: tolhs-nme35pyr-gly-betacbph

6035: bim-25oxaz-gly-aspaba

6036: bhs-nme35pyr-bala-betabnaphth

6037: ibhs-24thioph-bala-betainyl

6038: phhs-ithiadiaz-gly-betaibph

6039: tolhs-nme35pyr-gly-betaftrif

6040: ur-25thiaz-gly-betainyl

6041: bim-oxadiaz-leu-betadcph

6042: phhs-oxadiaz-gly-betaipr

6043: tolhs-25thiaz-bala-betafphe

6044: cima-24thiaz-gly-betainyl

6045: ibhs-25oxaz-gly-csdap

6046: bhs-25oxaz-bala-betathio3

6047: phhs-me25thioph-gly-betapy

6048: tolhs-me24thiaz-gly-beta34meoph

01/283/02 / PB

235

6049: bim-25oxaz-phe-betapy

6050: tolhs-25thiaz-bala-betaphethio

6051: dhim-24thiaz-ala-betainyl

6052: tolhs-oxadiaz-bala-betaet

6053: tolhs-me24thiaz-ala-zdap

6054: tolhs-25oxaz-bala-betatos

6055: ibhs-24thiaz-gly-betatrif

6056: tolhs-oxadiaz-gly-betahbcph

6057: ibhs-25oxaz-gly-betaol

6058: 2py-triaz-leu-psdap

6059: phhs-nme35pyr-gly-betahmofu

6060: bhs-ithiadiaz-bala-betafphe

6061: phhs-nme35pyr-gly-busu2be

6062: tolhs-me25thioph-leu-psdap

6063: thazep-42pym-gly-betapy

6064: ibhs-oxadiaz-bala-beta13bendi

6065: tolhs-25thiaz-gly-betafu3

6066: ibhs-oxadiaz-gly-betacbph

6067: gua-25thiaz-gly-betabpy

6068: phhs-nme35pyr-bala-csdap

6069: bim-53pyrazo-gly-psdap

6070: ibhs-ithiadiaz-bala-betaimide

6071: bhs-52thiaz-ala-zdap

6072: ibhs-24thiaz-bala-betaheph

6073: tolhs-25oxaz-gly-betatos

6074: 2py-24oxaz-bala-betadcph

6075: bhs-35thioph-leu-zdap

6076: bhs-ithiadiaz-bala-zdapch

6077: bhs-24thioph-nmgly-betaanaphth

6078: tolhs-25methiaz-gly-psdap

6079: bhs-me24oxaz-ala-betapy

01/283/02 / PB

236

6080: ibhs-25methiaz-gly-betadhbfu

6081: bhs-25thiaz-bala-ibsdap

6082: tolhs-nme35pyr-gly-betahdbph

6083: 2py-42nmeim-bala-betaibph

6084: phhs-24thiaz-gly-betadbph

6085: phhs-25oxaz-bala-betafphe

6086: 2py-26py-gly-zdap

6087: tolhs-oxadiaz-gly-betabthioph

6088: tolhs-25oxaz-bala-betadtrif

6089: bim-me25oxaz-leu-betaph

6090: ibhs-ithiadiaz-bala-beta34meoph

6091: phhs-nme35pyr-gly-zdaptb

6092: ibhs-24thiaz-bala-aspibua

6093: tolhs-24thioph-gly-betabpy

6094: bhs-ithiadiaz-gly-betadmoph

6095: gua-24thiaz-gly-betaphethio

6096: phhs-oxadiaz-bala-betadtrif

6097: ibhs-24thioph-bala-asppha

6098: phhs-nme35pyr-gly-betacthioph

6099: tolhs-25methiaz-bala-betaanaphth

6100: bhs-ithiadiaz-gly-betadcphch

6101: bhs-25methiaz-bala-betahni

6102: bhs-24thiaz-gly-psdapch

6103: bim-42nmeim-leu-betadcph

6104: tolhs-24thioph-bala-beta34meoph

6105: tolhs-24thiaz-bala-betafph

6106: tolhs-oxadiaz-gly-betaph

6107: phhs-ithiadiaz-gly-aspaba

6108: phhs-25oxaz-bala-ibsdap

6109: ibhs-25thiaz-gly-betabpy

6110: bhs-25methiaz-bala-betabnaphth

01/283/02 / PB

237

6111: tolhs-25oxaz-bala-betambiph

6112: tolhs-me25thioph-gly-beta34meoph

6113: tolhs-25oxaz-bala-betathiome

6114: dhim-25thioph-gly-betainyl

6115: ibhs-25oxaz-bala-aspibua

6116: phhs-oxadiaz-gly-suabu

6117: ibhs-nme35pyr-bala-beta35dbph

6118: 2py-25methiaz-leu-psdap

6119: bim-thiadiaz-gly-psdap

6120: ibhs-ithiadiaz-gly-betadcphch

6121: tolhs-oxadiaz-bala-betaibph

6122: bhs-ithiadiaz-bala-betafph

6123: ibhs-oxadiaz-bala-betahdbph

6124: bhs-25thiaz-bala-betafph

6125: phhs-nme35pyr-gly-betapym

6126: ibhs-25oxaz-bala-betadcph

6127: phhs-25oxaz-bala-betahdbph

6128: tolhs-oxadiaz-bala-betadmoph

6129: tolhs-24thioph-gly-betahdcph

6130: bhs-25methiaz-bala-betaph

6131: bhs-25thiaz-gly-betapyee

6132: tolhs-25methiaz-bala-betaimide

6133: gua-42pym-gly-betathio3

6134: bhs-25methiaz-nmgly-beta23meoph

6135: sabhs-42nmeim-gly-betapy

6136: bhs-24thiaz-bala-betathioph

6137: impy-25methiaz-bala-betaphethioa

6138: bhs-nme35pyr-gly-suabu

6139: tolhs-ithiadiaz-gly-betapy

6140: phhs-oxadiaz-gly-zdaptb

6141: phhs-ithiadiaz-gly-betahcbph

01/283/02 / PB

238

6142: tolhs-me24oxaz-ala-psdap

6143: bhs-oxadiaz-gly-betahmph

6144: ibhs-ithiadiaz-bala-betamesu

6145: bim-52thiaz-ala-zdap

6146: bhs-24thioph-ala-beta34dcph

6147: ibhs-24thiaz-bala-ibsdap

6148: tolhs-ithiadiaz-bala-betabnaphth

6149: ibhs-oxadiaz-gly-betadcphtb

6150: tolhs-oxadiaz-bala-betafphe

6151: tolhs-nme35pyr-gly-betapytb

6152: bhs-53pyrazo-ala-betadcph

6153: 2py-26py-nmala-zdap

6154: bhs-25oxaz-gly-betaheph

6155: bhs-25thiaz-gly-betapym

6156: bhs-24thiaz-leu-betapy

6157: phhs-oxadiaz-bala-betadhbfu

6158: phhs-oxadiaz-bala-asppha

6159: bhs-25thioph-gly-betainyl

6160: tolhs-oxadiaz-gly-zdap

6161: impy-25thiaz-ala-betapy

6162: tolhs-25methiaz-gly-busu2be

6163: 2py-35thioph-leu-psdap

6164: phhs-25methiaz-bala-betabpy

6165: 2py-26py-gly-betabnaphth

6166: bhs-25methiaz-bala-betahbcph

6167: ibhs-24thioph-gly-betaipr

6168: bhs-oxadiaz-bala-betaimide

6169: impy-25oxaz-bala-betabdimo

6170: gua-24thiaz-gly-betapbiph

6171: tolhs-24thioph-gly-beta13bendi

6172: bhs-24thioph-bala-betabph

01/283/02 / PB

239

6173: bhs-24thiaz-bala-betaimide

6174: ibhs-24thioph-gly-betadhbfu

6175: tolhs-24thiaz-gly-betabediox

6176: phhs-25oxaz-gly-betatrif

6177: bhs-triaz-gly-zdap

6178: bhs-25thiaz-gly-beta4bph

6179: tolhs-25thiaz-bala-betabenfu

6180: bhs-24thiaz-gly-betaheph

6181: bhs-nme35pyr-leu-zdap

6182: impy-42nmeim-bala-betabpy

6183: bhs-25methiaz-bala-aspibua

6184: tolhs-25thiaz-gly-betainyl

6185: tolhs-me24thioph-leu-betaph

6186: 2py-ithiadiaz-gly-zdap

6187: impy-25oxaz-gly-betafu2

6188: tolhs-me25oxaz-gly-beta34meoph

6189: thpy-24thiaz-gly-betadcph

6190: 2py-25oxaz-gly-aspaba

6191: tolhs-24thiaz-bala-zdap

6192: thpym-2thioph-gly-zdap

6193: phhs-25thiaz-bala-betahcbph

6194: ibhs-25methiaz-gly-betapyr

6195: bhs-ithiadiaz-bala-betaimide

6196: 2py-me25thiaz-bala-betadcph

6197: bhs-25thiaz-gly-betafbph

6198: phhs-24thiaz-gly-betahcbph

6199: phhs-25thiaz-gly-betabmph

6200: bhs-25oxaz-gly-betabenfu

6201: bhs-ithiadiaz-bala-betaanaphth

6202: bim-me24thioph-gly-betapy

6203: bhs-24thioph-ala-beta3quin

01/283/02 / PB

240

6204: tolhs-25oxaz-bala-betahdbph

6205: bhs-oxadiaz-gly-psdap

6206: bhs-25oxaz-bala-betatos

6207: ibhs-oxadiaz-bala-betapyr

6208: tolhs-me24thiaz-bala-beta34meoph

6209: 2 pmhs-25methiaz-gly-betameph

6210: phhs-25oxaz-gly-betah35dc

6211: hyd-42pym-gly-psdap

6212: ibhs-ithiadiaz-gly-betaet

6213: 2py-me24thioph-gly-betapy

6214: phhs-24thiaz-gly-betahbcph

6215: phhs-oxadiaz-bala-zdap

6216: phhs-ithiadiaz-bala-betapyr

6217: phhs-24thioph-gly-asppha

6218: bhs-24thioph-bala-betaanaphth

6219: bhs-24thiaz-bala-betahbcph

6220: 2py-25methiaz-bala-zdap

6221: bhs-ithiadiaz-gly-betadbph

6222: 2 pmhs-25methiaz-gly-betahbcph

6223: bhs-ithiadiaz-gly-betabpy

6224: bim-25thiaz-bala-betafphe

6225: phhs-24thiaz-bala-betahbcph

6226: ibhs-24thiaz-bala-betaimide

6227: bhs-25thiaz-bala-betadtrif

6228: bhs-35fur-ala-zdap

6229: bhs-ithiadiaz-bala-aspaba

6230: bhs-24thiaz-bala-betapytb

6231: tolhs-25oxaz-bala-beta23meoph

6232: bim-24thioph-bala-betafphe

6233: ibhs-24thioph-bala-betadcphtb

6234: bim-triaz-leu-zdap

01/283/02 / PB

241

6235: tolhs-25methiaz-bala-aspaba

6236: bhs-25oxaz-gly-zdapee

6237: bhs-nme35pyr-bala-betadhbfu

6238: ibhs-25oxaz-gly-betainyl

6239: phhs-me24thiaz-leu-betapy

6240: phhs-nme35pyr-bala-betatrif

6241: bhs-nme35pyr-gly-betapych

6242: bim-nme35pyr-gly-psdap

6243: phhs-ithiadiaz-gly-zdapch

6244: bhs-42oxaz-gly-psdap

6245: bhs-me24thiaz-ala-psdap

6246: tolhs-25methiaz-bala-betaet

6247: bhs-me24oxaz-bala-betadcph

6248: phhs-25methiaz-bala-betaoxope

6249: bhs-oxadiaz-gly-betabthioph

6250: tolhs-25methiaz-gly-betahdbph

6251: phhs-oxadiaz-gly-betabph

6252: ibhs-ithiadiaz-gly-betaphethioa

6253: tolhs-25oxaz-bala-beta35dbph

6254: tolhs-24thiaz-gly-betadbph

6255: ibhs-25oxaz-gly-betafbph

6256: impy-25thiaz-bala-betainyl

6257: 2py-24thioph-gly-zdap

6258: phhs-oxadiaz-gly-psdaptb

6259: dhthi-25thiaz-bala-betadcph

6260: ibhs-24thiaz-gly-betafu3

6261: phhs-me24oxaz-ala-betadcph

6262: bhs-ithiadiaz-bala-betadtrif

6263: bhs-ithiadiaz-nmgly-beta34meoph

6264: bhs-24thiaz-gly-betapytb

6265: 2py-24thioph-ala-psdap

01/283/02 / PB

242

6266: nmhs-26py-gly-betapy

6267: bim-26py-ala-psdap

6268: gua-26py-gly-betamesu

6269: 2py-oxadiaz-bala-aspbzla

6270: phhs-24thioph-bala-betadcphch

6271: gua-42pym-gly-betacbph

6272: bhs-24thiaz-bala-betabpy

6273: phhs-ithiadiaz-bala-betainyl

6274: phhs-ithiadiaz-gly-betadcphch

6275: phhs-25thiaz-bala-betahph

6276: ibhs-25methiaz-bala-betapyee

6277: ibhs-24thiaz-gly-aspbzla

6278: phhs-24thiaz-bala-betaoxope

6279: ibhs-24thioph-bala-betaphethioa

6280: tolhs-ithiadiaz-gly-betamethi

6281: bim-24thiaz-gly-betainyl

6282: phhs-25oxaz-bala-betapym

6283: tolhs-me24oxaz-bala-zdap

6284: bhs-25thioph-bala-betapy

6285: tolhs-24thioph-bala-betaimide

6286: bim-25thiaz-gly-aspbzla

6287: tolhs-ithiadiaz-gly-betadtrif

6288: ibhs-24thiaz-bala-betaftrif

6289: 2py-thiadiaz-bala-psdap

6290: phhs-25oxaz-bala-betabmph

6291: phhs-nme35pyr-gly-betahmph

6292: 2py-53pyrazo-gly-betadcph

6293: bhs-me24thiaz-leu-psdap

6294: bim-24im-gly-betadcph

6295: 2py-24oxaz-ala-betameph

6296: tolhs-24thiaz-gly-betahbcph

01/283/02 / PB

243

6297: phhs-25methiaz-bala-beta35dbph

6298: phhs-25thiaz-gly-betapyr

6299: ibhs-25thiaz-bala-betadbph

6300: bhs-nme35pyr-bala-betaet

6301: bim-me25thiaz-gly-zdap

6302: phhs-25thiaz-bala-betaanaphth

6303: bhs-nme35pyr-gly-betaol

6304: phhs-24thioph-bala-betadtrif

6305: phhs-me25thiaz-leu-beta34meoph

6306: ibhs-25thiaz-gly-betamethi

6307: bim-24thioph-leu-zdap

6308: bhs-ithiadiaz-bala-betathio3

6309: 2 pmhs-24thiaz-gly-betabpy

6310: bhs-24thiaz-gly-betapym

6311: phhs-25methiaz-gly-betampy

6312: bim-25oxaz-bala-asppha

6313: impy-42nmeim-gly-betamethioph

6314: tolhs-nme35pyr-bala-betahcbph

6315: bhs-oxadiaz-bala-betabnaphth

6316: bhs-nme35pyr-gly-betaipr

6317: ibhs-24thiaz-bala-betahc

6318: tolhs-25methiaz-gly-betaanaphth

6319: 2py-me25thioph-bala-betaph

6320: tolhs-24thioph-gly-betapych

6321: ibhs-oxadiaz-gly-betabenfu

6322: phhs-25thiaz-gly-betamesu

6323: tolhs-me24thioph-bala-betaph

6324: dimethpym-26py-gly-betahdcph

6325: ibhs-25thiaz-gly-beta34meoph

6326: bim-me25thiaz-gly-betapy

6327: phhs-24thioph-gly-betapym

01/283/02 / PB

244

6328: 2py-me25thiaz-ala-beta34meoph

6329: phhs-oxadiaz-bala-betadbph

6330: ibhs-nme35pyr-bala-betafbph

6331: ibhs-25thiaz-bala-betatrif

6332: tolhs-oxadiaz-gly-betaipr

6333: bim-me25thiaz-bala-betapy

6334: bhs-25oxaz-gly-betahc

6335: ibhs-24thioph-bala-betadtrif

6336: bhs-nme35pyr-gly-betahmo

6337: 2py-52thiaz-gly-betadcph

6338: bhs-35fur-leu-betadcph

6339: dhim-26py-gly-betainyl

6340: bim-me24thiaz-ala-zdap

6341: ibhs-nme35pyr-gly-betamesu

6342: ibhs-oxadiaz-bala-aspibua

6343: tolhs-24thiaz-bala-psdapee

6344: bim-me24oxaz-bala-psdap

6345: bhs-me24thioph-gly-psdap

6346: bhs-24thioph-gly-betaet

6347: ibhs-ithiadiaz-bala-beta23meoph

6348: 2py-25thiaz-bala-suabu

6349: bhs-me24thiaz-bala-betadcph

6350: 2py-25thiaz-bala-betaet

6351: bhs-oxadiaz-gly-asppha

6352: ibhs-24thioph-bala-beta13bendi

6353: phhs-25methiaz-bala-betabnaphth

6354: 2py-25thiaz-gly-betacthioph

6355: dhim-25oxaz-bala-betadcph

6356: phhs-me24thioph-bala-psdap

6357: 2py-ithiadiaz-bala-aspibua

6358: phhs-24thioph-gly-betadmoph

01/283/02 / PB

245

6359: bhs-ithiadiaz-bala-betadcphch

6360: ibhs-24thiaz-bala-betadmoph

6361: phhs-24thioph-bala-beta4bph

6362: ibhs-25oxaz-bala-betapych

6363: ibhs-24thioph-bala-betabph

6364: bhs-25oxaz-ala-betapy

6365: bim-25fur-leu-betapy

6366: ibhs-24thioph-bala-beta35dbph

6367: bhs-24thioph-bala-betaftrif

6368: bhs-25fur-ala-zdap

6369: bhs-25thiaz-bala-beta34meoph

6370: thazep-26py-gly-betapy

6371: bhs-nme35pyr-gly ~ betathio3

6372: 2 pmhs-25oxaz-bala-betaoxope

6373: tolhs-oxadiaz-gly-betacph

6374: phhs-25methiaz-bala-psdaptb

6375: bim-25thiaz-nmala-betadcph

6376: bim-25thiaz-bala-aspbzla

6377: bhs-24thiaz-nmgly-betafphe

6378: tolhs-ithiadiaz-gly-betaph

6379: ibhs-ithiadiaz-bala-betaol

6380: impy-24thioph-gly-betathiobe

6381: tolhs-25methiaz-gly-betacthioph

6382: ibhs-24thiaz-bala-betameph

6383: 2py-25methiaz-bala-betaet

6384: bhs-25oxaz-nmgly-beta34meoph

6385: gua-24thiaz-gly-betapy

6386: tolhs-25oxaz-bala-betahcbph

6387: bhs-42nmeim-bala-betacthioph

6388: tolhs-25methiaz-gly-betameph

6389: ibhs-25thiaz-bala-betathiome

01/283/02 / PB

246

6390: bhs-nme35pyr-bala-betathio3

6391: phhs-oxadiaz-bala-betahmofu

6392: ibhs-ithiadiaz-bala-betadmoph

6393: it) hs-24thiaz-gly-aspaba

6394: impy-25thiaz-bala-betamesu

6395: ibhs-24thiaz-gly-betaibph

6396: bhs-25oxaz-bala-betainyl

6397: bhs-25methiaz-bala-betahph

6398: gua-25thiaz-nmgly-betapy

6399: bhs-24thioph-gly-aspbzla

6400: bhs-25oxaz-nmgly-ibsdap

6401: 2py-24im-leu-zdap

6402: phhs-nme35pyr-bala-betafbph

6403: tolhs-25oxaz-bala-zdap

6404: phhs-oxadiaz-gly-betahmofu

6405: bim-42nmeim-bala-betathiobe

6406: bhs-25oxaz-bala-zdaptb

6407: ibhs-25thiaz-gly-aspbzla

6408: bim-24oxaz-bala-betapy

6409: ibhs-25oxaz-gly-beta13bendi 6410: bhs-24thiaz-gly-betahbcph

6411: ibhs-25methiaz-bala-betapbiph 6412: tolhs-ithiadiaz-bala-betadito 6413: phhs-ithiadiaz-bala-betatrif 6414: tolhs-24thiaz-gly-betadcphch 6415: bim-25methiaz-bala-betacph 6416: ph -gly-betamethioph 6417: tolhs-25methiaz-gly-betapyr 6418: bhs-ithiadiaz-gly-psdaptb 6419: ibhs-ithiadiaz-bala-betapyr 6420: phhs-24thioph-bala-betahdbph

01/283/02 / PB

247

6421: dlhim-42pym-ala-betapy

6422: bhs-25thiaz-ala-betambiph

6423: 2py-24thioph-gly-asppha

6424: phhs-24thiaz-bala-betafph

6425: 2py-24thiaz-bala-betaet

6426: tolhs-ithiadiaz-bala-betahph

6427: 2py-nme35pyr-ala-betadcph

6428: phhs-me24thioph-bala-betaph

6429: bhs-25oxaz-gly-betaoxope

6430: phhs-24thiaz-gly-betaimide

6431: tolhs-25methiaz-gly-betafphe

6432: bhs-35thioph-leu-betapy

6433: ibhs-25thiaz-bala-betadcphch

6434: tolhs-25thiaz-bala-betatbuph

6435: bhs-24im-gly-betadcph

6436: 2py-26py-gly-betameph

6437: hs-25thioph-gly-zdap

6438: phhs-me24oxaz-gly-zdap

6439: tolhs-25oxaz-bala-betadhbfu

6440: bhs-24thioph-bala-betabdimo

6441: ibhs-ithiadiaz-bala-betahdbph

6442: phhs-24thioph-bala-betapym

6443: phhs-25methiaz-gly-betadcphee

6444: bhs-25methiaz-gly-betahph

6445: phhs-24thiaz-bala-betaheph

6446: bhs-25oxaz-gly-betaoxaz

6447: bhs-24thiaz-bala-aspibua

6448: phhs-ithiadiaz-gly-betabthioph

6449: agua-26py-gly-betainyl

6450: phhs-24thioph-gly-betahmofu

6451: bhs-oxadiaz-bala-betatrif

01/283/02 / PB

248

6452: bhs-me24thioph-ala-betaph

6453: tolhs-25methiaz-gly-betabediox

6454: tolhs-24thioph-bala-betabediox

6455: bhs-24thioph-gly-betambiph

6456: bim-35fur-leu-betapy

6457: phhs-24thiaz-gly-csdap

6458: agua-42nmeim-gly-betapy

6459: tolhs-me24thioph-ala-psdap

6460: tolhs-ithiadiaz-bala-betabdimo

6461: tolhs-me25oxaz-gly-betaph

6462: 2py-oxadiaz-gly-asppha

6463: tolhs-25thiaz-gly-betahph

6464: bhs-nme35pyr-gly-betahdbph

6465: bhs-24thiaz-gly-ibsdap

6466: phhs-nme35pyr-gly-beta4bph

6467: bhs-25oxaz-bala-betathiome

6468: tolhs-25thiaz-bala-betaamibe

6469: tolhs-25oxaz-bala-zdapee

6470: impy-25thiaz-bala-betaftrif

6471: tolhs-25oxaz-gly-betadcphtb

6472: bhs-me24thioph-bala-psdap

6473: bhs-nme35pyr-nmgly-betathio3

6474: bhs-oxadiaz-gly-betapym

6475: phhs-24thioph-gly-betadito

6476: ibhs-25oxaz-bala-betapbiph

6477: tolhs-nme35pyr-bala-betatrif

6478: bhs-25methiaz-bala-beta34dcph

6479: bim-25methiaz-gly-betadmph

6480: phhs-25methiaz-gly-betahc

6481: tolhs-24thiaz-bala-betah35dc

6482: bhs-me25thioph-ala-betaph

01/283/02 / PB 249

6483: tolhs-oxadiaz-gly-betahmph

6484: tolhs-25thiaz-bala-betatos

6485: tolhs-ithiadiaz-gly-betaol

6486: tolhs-24thioph-bala-betadmoph

6487: tolhs-oxadiaz-gly-betainyl

6488: phhs-25methiaz-bala-beta4bph

6489: bim-thiadiaz-ala-betadcph

6490: ur-25methiaz-gly-betadcph

6491: bim-42nmeim-nmgly-zdap

6492: tolhs-24thiaz-bala-betaph

6493: ibhs-24thioph-gly-betapyee

6494: thazep-24oxaz-giy-betainyl

6495: 4 pmhs-25thiaz-bala-betameph

6496: ibhs-25methiaz-gly-suabu

6497: tolhs-25thiaz-bala-betapym

6498: bhs-oxadiaz-gly-beta23meoph

6499: tolhs-nme35pyr-gly-psdap

6500: 2 pmhs-42nmeim-gly-betahmo

6501: phhs-ithiadiaz-bala-betaomebendi

6502: bhs-me24thiaz-ala-beta34meoph

6503: bhs-24thiaz-bala-beta3quin

6504: phhs-25methiaz-gly-betathioph

6505: tolhs-me25oxaz-gly-betapy

6506: phhs-24thioph-gly-betapyr

6507: tolhs-25oxaz-bala-betapym

6508: bhs-ithiadiaz-gly-betaph

6509: bim-25oxaz-leu-psdap

6510: impy-24thioph-bala-betaftrif

6511: phhs-24thioph-gly-betah35dc

6512: ibhs-24thiaz-gly-betadmoph

6513: bhs-42oxaz-ala-betapy

01/283/02 / PB

250

6514: thazep-42nmeim-bala-betameph

6515: bhs-24thiaz-bala-busu2be

6516: gua-25thiaz-gly-betahph

6517: gua-24thiaz-gly-betainyl

6518: bhs-25thiaz-gly-betahmofii

6519: phhs-nme35pyr-gly-betahmo

6520: bhs-25thiaz-gly-betaamibe

6521: phhs-24thioph-gly-betapy

6522: bhs-oxadiaz-gly-betadmph

6523: tolhs-me24oxaz-ala-betadcph

6524: thazep-25methiaz-bala-zdap

6525: tolhs-ithiadiaz-bala-aspibua

6526: phhs-me25oxaz-bala-zdap

6527: phhs-nme35pyr-gly-betadito

6528: 2py-24oxaz-bala-psdap

6529: bhs-25methiaz-bala-beta35dbph

6530: phhs-24thioph-bala-zdaptb

6531: bhs-35fur-gly-betadcph

6532: phhs-25thiaz-gly-beta34meoph

6533: phhs-25thiaz-gly-betaphethio

6534: agua-24oxaz-gly-betainyl

6535: phhs-25oxaz-bala-betahc

6536: 2py-53pyrazo-leu-zdap

6537: ibhs-25methiaz-bala-aspibua

6538: 2py-24thiaz-gly-betapy

6539: tolhs-ithiadiaz-gly-betaphethio

6540: ibhs-oxadiaz-bala-betaipr

6541: bhs-25thiaz-gly-betathio3

6542: gua-24oxaz-gly-betacbph

6543: bhs-24oxaz-gly-betapy

6544: tolhs-24thioph-bala-betafu2

01/283/02 / PB

251

6545: phhs-24thioph-gly-betamethi

6546: bhs-nme35pyr-bala-beta34dcph

6547: phhs-oxadiaz-bala-betaheph

6548: 2py-oxadiaz-gly-betapy

6549: bhs-25methiaz-nmgly-betameph

6550: 2py-me24oxaz-ala-betadcph

6551: bim-triaz-ala-psdap

6552: ibhs-25thiaz-gly-betabenfu

6553: bim-42nmeim-bala-betapy

6554: bhs-25thiaz-gly-betabnaphth

6555: bhs-ithiadiaz-bala-betadhbfu

6556: tolhs-25thiaz-gly-betaipro

6557: dhpyrr-26py-gly-psdap

6558: bhs-24thiaz-ala-betadcph

6559: hs-25thiaz-gly-betainyl

6560: bhs-25oxaz-gly-betamethi

6561: bhs-nme35pyr-bala-beta34meoph

6562: ibhs-25methiaz-bala-betaomebendi

6563: phhs-24thioph-gly-betadcphtb

6564: ibhs-25thiaz-gly-betatbuph

6565: ibhs-oxadiaz-gly-betafluo

6566: 2 pmhs-24thiaz-phe-zdap

6567: ibhs-24thioph-gly-betabph

6568: 2py-42nmeim-gly-betaimide

6569: ibhs-25methiaz-gly-betahni

6570: phhs-25methiaz-bala-psdapch

6571: phhs-25oxaz-gly-betabpy

6572: bhs-24thiaz-nmgly-beta13bendi

6573: ibhs-oxadiaz-gly-betabediox

6574: ibhs-nme35pyr-gly-betacph

6575: bim-24im-leu-psdap

01/283/02 / PB

252

6576: bim-25thiaz-gly-betaomebendi

6577: tolhs-oxadiaz-gly-zdapee

6578: ibhs-24thioph-gly-betahcbph

6579: ibhs-25methiaz-bala-betainyl

6580: ibhs-ithiadiaz-bala-zdapee

6581: tolhs-ithiadiaz-bala-betahc

6582: tolhs-24thioph-gly-betamesu

6583: tolhs-24thiaz-bala-suabii

6584: bhs-24im-ala-betadcph

6585: gua-24thiaz-gly-beta4bph

6586: bhs-25thiaz-bala-betaipr

6587: ibhs-25oxaz-gly-betabnaphth

6588: ibhs-nme35pyr-gly-betadito

6589: bim-me25thiaz-ala-zdap

6590: bhs-24thioph-bala-zdapee

6591: ibhs-oxadiaz-gly-betafu2

6592: 2py-me25thiaz-leu-betapy

6593: phhs-24thiaz-bala-betaipr

6594: tolhs-ithiadiaz-bala-betafluo

6595: ibhs-24thioph-bala-betaamibe

6596: 2py-25thioph-gly-betapy

6597: bhs-25oxaz-leu-betapy

6598: tolhs-ithiadiaz-gly-betaamibe

6599: bhs-me24oxaz-leu-betadcph

6600: bhs-nme35pyr-bala-betafluo

6601: bhs-24thiaz-ala-betabpy

6602: ibhs-25methiaz-bala-betaipr

6603: bhs-24thiaz-bala-betadhbfu

6604: tolhs-25thiaz-gly-beta13bendi

6605: phhs-nme35pyr-gly-betadcphee

6606: bhs-25oxaz-gly-betabmph

01/283/02 / PB

253

6607: phhs-25methiaz-gly-betaipr

6608: tolhs-25oxaz-gly-betaftrif

6609: bhs-25oxaz-bala-betaphethioa

6610: ibhs-24thioph-gly-betaheph

6611: bhs-24thioph-gly-siiabu

6612: tolhs-25methiaz-bala-betamethioph

6613: tolhs-24thioph-gly-asppha

6614: ibhs-25methiaz-bala-betaol

6615: phhs-24thiaz-bala-betapytb

6616: 2 pmhs-42nmeim-bala-betafu2

6617: tolhs-oxadiaz-gly-aspibua

6618: bhs-oxadiaz-nmgly-ibsdap

6619: tolhs-24thioph-gly-betapym

6620: ibhs-nme35pyr-bala-betahmofu

6621: bhs-35thioph-bala-zdap

6622: 2 pmhs-25methiaz-gly-betahb

6623: gua-26py-gly-betah35dc

6624: phhs-24thiaz-gly-betapytb

6625: bim-42nmeim-gly-betaphethioa

6626: 2py-triaz-gly-zdap

6627: bhs-24thiaz-gly-zdap

6628: bhs-24thiaz-bala-betampy

6629: bim-25oxaz-gly-asppha

6630: tolhs-ithiadiaz-bala-beta35dbph

6631: phhs-nme35pyr-bala-asppha

6632: ibhs-oxadiaz-gly-betadhbfu

6633: ibhs-ithiadiaz-bala-betadcphch

6634: 2py-ithiadiaz-gly-aspaba

6635: bhs-25oxaz-nmgly-beta3quin

6636: ibhs-25oxaz-bala-zdapee

6637: bhs-25oxaz-gly-betabthioph

01/283/02 / PB

254

6638: bhs-oxadiaz-gly-betabph

6639: phhs-oxadiaz-bala-betameph

6640: tolhs-me25thioph-bala-betapy

6641: tolhs-ithiadiaz-gly-betahdbph

6642: bim-24thiaz-gly-betadcph

6643: ibhs-nme35pyr-gly-betaphethioa

6644: tolhs-25thiaz-gly-betathio3

6645: phhs-24thioph-bala-betapych

6646: 2py-35fur-leu-betapy

6647: bhs-24chin-gly-zdap

6648: tolhs-oxadiaz-gly-betaamibe

6649: bhs-24thioph-nmgly-betahph

6650: ibhs-oxadiaz-gly-betabdimo

6651: 2py-me24oxaz-gly-beta34meoph

6652: bhs-25thiaz-gly-betaimide

6653: bim-24thiaz-ala-betadcph

6654: tolhs-25oxaz-gly-zdap

6655: bhs-ithiadiaz-gly-betacbph

6656: tolhs-nme35pyr-gly-beta13bendi

6657: 2py-thiadiaz-bala-betapy

6658: dhim-24oxaz-gly-psdap

6659: bhs-nme35pyr-bala-psdap

6660: tolhs-oxadiaz-bala-psdapee

6661: gua-25thiaz-gly-betadmoph

6662: bhs-me24thioph-ala-betadcph

6663: bhs-25methiaz-gly-betapbiph

6664: bhs-25oxaz-bala-betadcphch

6665: ibhs-ithiadiaz-bala-betadmph

6666: bim-23thioph-gly-zdap

6667: phhs-24thiaz-bala-betahb

6668: tolhs-25methiaz-gly-betapy

01/283/02 / PB

255

6669: bhs-24thioph-met-betadcph

6670: tolhs-24thioph-bala-betapych

6671: 2py-25thioph-leu-betapy

6672: ibhs-25oxaz-bala-asppha

6673: phhs-me24oxaz-bala-zdap

6674: ibhs-25oxaz-bala-betabnaphth

6675: tolhs-24thioph-gly-betapbiph

6676: bhs-ithiadiaz-leu-betapy

6677: bhs-25oxaz-bala-zdap

6678: phhs-25methiaz-gly-betahcbph

6679: tolhs-24thiaz-bala-betahmph

6680: tolhs-nme35pyr-gly-betabpy

6681: ibhs-25methiaz-gly-betaphethio

6682: tolhs-oxadiaz-bala-betahc

6683: phhs-25oxaz-bala-zdaptb

6684: ibhs-nme35pyr-bala-betabnaphth

6685: ibhs-25methiaz-gly-aspbzla

6686: tolhs-24thiaz-bala-betafluo

6687: bhs-ithiadiaz-nmgly-betacph

6688: tolhs-25oxaz-bala-betaipro

6689: bim-25thioph-leu-betapy

6690: ibhs-oxadiaz-bala-betathiobe

6691: gua-24thiaz-gly-betathiome

6692: bhs-25thioph-ala-betadcph

6693: 2py-24oxaz-ala-betapy

6694: phhs-25methiaz-bala-betahcbph

6695: ibhs-25thiaz-bala-betathioph

6696: ibhs-25oxaz-bala-betapytb

6697: phhs-25thiaz-gly-suabu

6698: phhs-me25thioph-bala-zdap

6699: phhs-oxadiaz-gly-betahmo

01/283/02 / PB

256

6700: bhs-25thiaz-gly-betabpy

6701: phhs-24thiaz-bala-betainyl

6702: phhs-24thiaz-bala-betaph

6703: bhs-25methiaz-nmgly-betainyl

6704: bhs-nme35pyr-gly-betabpy

6705: bhs-25methiaz-bala-betadtrif

6706: phhs-24thiaz-bala-betafluo

6707: 2py-25thiaz-bala-zdap

6708: 2py-25oxaz-bala-asppha

6709: tolhs-25methiaz-bala-betafu2

6710: bhs-25thiaz-bala-beta34dcph

6711: 2py-25oxaz-ala-betadcph

6712: bhs-25methiaz-bala-zdap

6713: phhs-oxadiaz-gly-betamethi

6714: phhs-ithiadiaz-bala-betamesu

6715: bhs-24thiaz-bala-betamethioph

6716: bhs-25oxaz-gly-betapym

6717: bhs-ithiadiaz-ala-betainyl

6718: phhs-24thioph-gly-betabmph

6719: ibhs-25methiaz-gly-betadmph

6720: ibhs-24thiaz-bala-betahmo

6721: tolhs-24thiaz-gly-beta34dcph

6722: phhs-25methiaz-gly-betaphethioa

6723: 2py-me25oxaz-leu-betaph

6724: phhs-ithiadiaz-bala-betathioph

6725: bhs-me25thiaz-leu-betadcph

6726: bhs-25oxaz-bala-betaol

6727: bhs-24thiaz-nmgly-betaanaphth

6728: ibhs-24thioph-bala-betamethioph

6729: phhs-25methiaz-bala-betamethi

6730: ibhs-nme35pyr-gly-zdapee

01/283/02 / PB

257

6731: bhs-24thioph-bala-beta13bendi

6732: ibhs-25oxaz-bala-psdapch

6733: ibhs-ithiadiaz-gly-betaoxope

6734: tolhs-25thiaz-gly-betaol

6735: tolhs-nme35pyr-gly-betadtrif

6736: bhs-26py-ala-betadcph

6737: tolhs-25thiaz-gly-betadcphtb

6738: impy-25methiaz-gly-betabediox

6739: bhs-25thioph-ala-betapy

6740: phhs-25thiaz-gly-betadito

6741: phhs-oxadiaz-gly-beta34dcph

6742: bim-25oxaz-gly-betabpy

6743: ibhs-25methiaz-bala-betadcph

6744: tolhs-25methiaz-bala-ibsdap

6745: phhs-oxadiaz-gly-betaftrif

6746: tolhs-oxadiaz-gly-betaoxaz

6747: 2py-thiadiaz-leu-zdap

6748: tolhs-me24thioph-leu-zdap

6749: ibhs-oxadiaz-bala-betaoxope

6750: bhs-ithiadiaz-gly-betaanaphth

6751: thazep-24thiaz-gly-betainyl

6752: tolhs-ithiadiaz-gly-betaipr

6753: bhs-35thioph-ala-psdap

6754: bhs-24thioph-bala-betapytb

6755: bhs-me25thiaz-ala-betapy

6756: bhs-25oxaz-gly-betaipro

6757: ibhs-25methiaz-bala-betahbcph

6758: bim-52thiaz-gly-betainyl

6759: ibhs-24thioph-bala-betafph

6760: 2py-25thioph-leu-zdap

6761: ibhs-25oxaz-bala-betaet

01/283/02 / PB

258

6762: bhs-me25thiaz-leu-betapy

6763: ibhs-25oxaz-gly-betabediox

6764: ibhs-nme35pyr-bala-betabpy

6765: phhs-24thioph-bala-betafph

6766: tolhs-25methiaz-gly-betah35dc

6767: tolhs-25oxaz-bala-aspibua

6768: 2py-oxadiaz-gly-zdap

6769: bhs-ithiadiaz-leu-psdap

6770: 2py-24oxaz-gly-psdap

6771: bhs-46pym-gly-betameph

6772: tolhs-ithiadiaz-bala-zdapch

6773: ibhs-25oxaz-gly-betathiome

6774: bhs-25oxaz-nmgly-betadmoph

6775: tolhs-25oxaz-bala-betahbcph

6776: ibhs-25oxaz-bala-betaphethio

6777: phhs-nme35pyr-bala-betadhbfu

6778: bhs-me24thioph-ala-zdap

6779: bhs-triaz-leu-psdap

6780: ibhs-24thioph-bala-aspibua

6781: bhs-24py-gly-betapy

6782: gua-25thiaz-gly-beta4bph

6783: ibhs-oxadiaz-bala-betabdimo

6784: gua-24thiaz-gly-betambiph

6785: bhs-nme35pyr-ala-beta23meoph

6786: bhs-24thioph-bala-betatbuph

6787: bhs-nme35pyr-bala-zdap

6788: ibhs-24thioph-bala-betafphe

6789: phhs-24thiaz-bala-aspbzla

6790: ibhs-ithiadiaz-gly-aspbzla

6791: bhs-24thiaz-bala-betaol

6792: bhs-25methiaz-gly-betadtrif

01/283/02 / PB

259

6793: ibhs-25methiaz-bala-betaanaphth

6794: tolhs-25oxaz-gly-betamethi

6795: phhs-oxadiaz-bala-betahb

6796: 2py-me25thiaz-bala-zdap

6797: bhs-24thiaz-gly-betainyl

6798: impy-25thiaz-bala-busu2be

6799: bhs-24thioph-gly-betadbph

6800: ibhs-oxadiaz-gly-aspibua

6801: 2py-25fur-leu-zdap

6802: ibhs-25thiaz-gly-betafbph

6803: tolhs-ithiadiaz-bala-betabediox

6804: impy-24thioph-bala-betafu3

6805: phhs-25methiaz-gly-beta35dbph

6806: tolhs-me24thioph-bala-beta34meoph

6807: bhs-oxadiaz-bala-betafphe

6808: tolhs-oxadiaz-bala-betafu2

6809: cima-25thiaz-gly-betainyl

6810: bhs-25oxaz-bala-betahph

6811: ibhs-25oxaz-bala-betatos

6812: ibhs-25thiaz-bala-betacbph

6813: gua-42pym-gly-betaol

6814: tolhs-ithiadiaz-bala-psdap

6815: 2py-26py-gly-betainyl

6816: bhs-24thioph-gly-betadhbfu

6817: tolhs-ithiadiaz-bala-betabph

6818: tolhs-24thioph-bala-betaheph

6819: phhs-25thiaz-gly-betabnaphth

6820: tolhs-25thiaz-bala-betathiobe

6821: bhs-oxadiaz-ala-beta34dcph

6822: phhs-me24oxaz-leu-betaph

6823: bhs-24thiaz-nmgly-betadito

01/283/02 / PB

260

6824: phhs-oxadiaz-gly-betahni

6825: 2py-25oxaz-bala-betamesu

6826: ibhs-nme35pyr-bala-betathiobe

6827: bhs-24thioph-gly-betaheph

6828: phhs-24thiaz-gly-zdapee

6829: ibhs-nme35pyr-gly-betadcphch

6830: tolhs-24thiaz-gly-betatos

6831: tolhs-ithiadiaz-bala-betahmo

6832: bhs-me24thiaz-gly-betameph

6833: dhim-me25thiaz-ala-betameph

6834: ibhs-24thiaz-bala-betampy

6835: ibhs-25oxaz-bala-psdaptb

6836: tolhs-25thiaz-bala-betampy

6837: ibhs-nme35pyr-gly-betampy

6838: tolhs-me25thiaz-gly-zdap

6839: tolhs-25thiaz-bala-betaftrif

6840: ibhs-24thiaz-gly-betafbph

6841: bhs-oxadiaz-ala-betadmph

6842: tolhs-oxadiaz-bala-betadito

6843: tolhs-25thiaz-bala-betamesu

6844: tolhs-25oxaz-gly-betadcphee

6845: gua-25thiaz-gly-beta35dbph

6846: tolhs-nme35pyr-gly-betaphethio

6847: gua-24oxaz-gly-beta34dcph

6848: 2py-24thiaz-ala-zdap

6849: tolhs-oxadiaz-gly-betafphe

6850: tolhs-25oxaz-gly-beta23meoph

6851: ibhs-24thiaz-bala-beta23meoph

6852: phhs-nme35pyr-gly-betahc

6853: gua-24oxaz-gly-betadmph

6854: bhs-25fur-gly-psdap

01/283/02 / PB

261

6855: bhs-24thiaz-gly-betadbph

6856: ibhs-25thiaz-gly-betabph

6857: 2py-triaz-ala-psdap

6858: tolhs-ithiadiaz-bala-csdap

6859: tolhs-ithiadiaz-gly-betadito

6860: tolhs-24thiaz-gly-betapyr

6861: bhs-ithiadiaz-gly-betafluo

6862: tolhs-24thioph-gly-betafu2

6863: ibhs-24thioph-gly-betathioph

6864: 2py-53pyrazo-bala-betadcph

6865: tolhs-oxadiaz-bala-betabenfu

6866: tolhs-25thiaz-bala-betahmo

6867: ibhs-oxadiaz-gly-betahb

6868: bhs-25thiaz-ala-betameph

6869: phhs-ithiadiaz-gly-betathiome

6870: phhs-oxadiaz-gly-betadbph

6871: tolhs-25oxaz-gly-betaoxope

6872: bhs-oxadiaz-bala-betadbph

6873: bhs-ithiadiaz-bala-betadcphee

6874: bhs-me24oxaz-gly-betadcph

6875: tolhs-25thiaz-gly-betaphethioa

6876: dhim-26py-ala-betameph

6877: tolhs-oxadiaz-gly-psdap

6878: tolhs-oxadiaz-bala-betahcbph

6879: bim-24thiaz-bala-aspbzla

6880: phhs-24thioph-gly-beta34dcph

6881: bim-42oxaz-leu-zdap

6882: phhs-25oxaz-bala-betathiobe

6883: tolhs-24thiaz-bala-betathio3

6884: 2py-35thioph-bala-zdap

6885: bim-25fur-bala-zdap

01/283/02 / PB 262

6886: bim-me25thioph-leu-psdap

6887: ibhs-25thiaz-gly-betafu2

6888: bhs-24thiaz-gly-betaamibe

6889: 2 pmhs-24thiaz-gly-betameph

6890: ibhs-24thioph-gly-psdapee

6891: phhs-25methiaz-gly-psdapch

6892: ibhs-24thiaz-gly-suabu

6893: bhs-25thiaz-ala-betapy

6894: dhim-52thiaz-ala-psdap

6895: tolhs-25thiaz-gly-zdaptb

6896: ibhs-24thiaz-gly-aspibua

6897: 2 pmhs-42nmeim-bala-beta23meoph

6898: 2py-52thiaz-gly-betapy

6899: bhs-ithiadiaz-gly-betathiome

6900: bhs-ithiadiaz-bala-betabnaphth

6901: 2py-24oxaz-leu-zdap

6902: tolhs-24thioph-bala-betaphethio

6903: bhs-35fur-gly-zdap

6904: hts-25thiaz-gly-betapy

6905: 2py-oxadiaz-bala-aspibua

6906: tolhs-nme35pyr-gly-betabdcph

6907: ibhs-ithiadiaz-bala-psdaptb

6908: ibhs-25methiaz-bala-betacbph

6909: 2py-25oxaz-bala-busu2be

6910: bim-me25thiaz-leu-betaph

6911: phhs-25thiaz-bala-betaphethioa

6912: ibhs-ithiadiaz-bala-betafluo

6913: gua-25thioph-gly-betadcph

6914: bhs-25thiaz-bala-betaomebendi

6915: phhs-25methiaz-bala-betaet

6916: 2 pmhs-42nmeim-bala-betahdbph

01/283/02 / PB

263

6917: bhs-35thioph-gly-zdap

6918: ibhs-oxadiaz-bala-ibsdap

6919: tolhs-24thiaz-gly-betaanaphth

6920: 2py-me24oxaz-leu-betadcph

6921: phhs-25methiaz-bala-psdapee

6922: pahs-42nmeim-bala-betadcph

6923: ibhs-oxadiaz-bala-betaol

6924: ibhs-25thiaz-gly-betapych

6925: bhs-42nmeim-leu-psdap

6926: tolhs-nme35pyr-gly-betadmoph

6927: phhs-24thioph-gly-ibsdap

6928: tolhs-me25thioph-gly-psdap

6929: phhs-25oxaz-gly-betaoxope

6930: bhs-oxadiaz-gly-aspaba

6931: tolhs-25thiaz-bala-betafluo

6932: tolhs-25methiaz-gly-betahb

6933: tolhs-ithiadiaz-gly-psdapee

6934: 2py-42nmeim-gly-betahc

6935: tolhs-25thiaz-gly-betaphethio

6936: bhs-ithiadiaz-bala-betamethi

6937: tolhs-25methiaz-gly-betabph

6938: bhs-24thioph-gly-betaanaphth

6939: phhs-25methiaz-gly-beta34meoph

6940: tolhs-25methiaz-gly-betadmoph

6941: bhs-24thiaz-gly-betadmph

6942: 2py-24thioph-gly-beta35dbph

6943: ibhs-25oxaz-gly-betabmph

6944: bhs-ithiadiaz-bala-beta34meoph

6945: bim-42oxaz-ala-betadcph

6946: tolhs-25methiaz-gly-betathiome

6947: ibhs-nme35pyr-bala-csdap

01/283/02 / PB

264

6948: bhs-ithiadiaz-ala-betamesu

6949: thpym-26py-gly-betahdcph

6950: 2py-ithiadiaz-bala-betapy

6951: tolhs-oxadiaz-gly-asppha

6952: bhs-nme35pyr-nmgly-betaanaphth

6953: phhs-25thiaz-bala-betahmo

6954: bhs-25oxaz-gly-betadhbfu

6955: bhs-24thiaz-nmgly-betacthioph

6956: tolhs-25thiaz-bala-ibsdap

6957: tolhs-nme35pyr-bala-beta23meoph

6958: bim-24thioph-gly-betadcph

6959: tolhs-24thioph-bala-betahc

6960: bhs-25thiaz-bala-betahcbph

6961: tolhs-24thiaz-bala-betadhbfu

6962: ibhs-25methiaz-bala-betadtrif

6963: phhs-25methiaz-bala-beta23meoph

6964: phhs-nme35pyr-bala-betampy

6965: bhs-25thiaz-gly-betahcbph

6966: bhs-ithiadiaz-ala-zdap

6967: tolhs-25thiaz-bala-betaimide

6968: phhs-25thiaz-gly-betaamibe

6969: bim-ithiadiaz-ala-betapy

6970: bhs-42pym-ala-betainyl

6971: tolhs-25thiaz-bala-betafu2

6972: 2 pmhs-24thioph-gly-betathiome

6973: imhs-24thiaz-gly-zdap

6974: dhim-52thiaz-gly-betapy

6975: tolhs-24thioph-bala-betamesu

6976: phhs-ithiadiaz-bala-betahmo

6977: gua-25thiaz-gly-betaibph

6978: ibhs-24thiaz-bala-betadito

01/283/02 / PB

265

6979: phhs-nme35pyr-gly-betambiph

6980: dhpyrr-25thioph-gly-betapy

6981: bhs-25thiaz-nmgly-beta13bendi

6982: bhs-42nmeim-gly-betaoxope

6983: bim-42pym-ala-betadcph

6984: tolhs-me24thioph-leu-psdap

6985: 2py-42nmeim-leu-betapy

6986: phhs-oxadiaz-bala-betamesu

6987: tolhs-24thioph-bala-aspaba

6988: dhim-26py-ala-zdap

6989: bhs-oxadiaz-bala-betampy

6990: ibhs-25thiaz-bala-betamethioph

6991: 2py-42pym-gly-betameph

6992: tolhs-ithiadiaz-bala-betadmph

6993: gua-24thiaz-gly-betahmo

6994: bhs-ithiadiaz-bala-betapym

6995: bhs-24thioph-ala-betacthioph

6996: bhs-24thiaz-bala-betahph

6997: phhs-ithiadiaz-gly-betadito

6998: phhs-me24oxaz-ala-betapy

6999: bhs-52thiaz-ala-betapy

7000: bhs-me25oxaz-ala-zdap

7001: ibhs-25oxaz-bala-betabenfu

7002: phhis-24thiaz-bala-beta34dcph

7003: ibhs-24thiaz-bala-betadcphch

7004: ibhs-25thiaz-gly-betatrif

7005: ibhs-oxadiaz-gly-betahbcph

7006: bhs-nme35pyr-bala-betaimide

7007: bhs-oxadiaz-bala-betaamibe

7008: phhs-25oxaz-bala-betafu2

7009: tolhs-24thioph-gly-betahbcph

01/283/02 / PB

266

7010: 2py-25fur-bala-betapy

7011: 2py-25oxaz-bala-betainyl

7012: tolhs-me25thiaz-leu-betaph

7013: bhs-ithiadiaz-bala-betadmph

7014: bhs-nme35pyr-gly-busu2be

7015: bhs-me24thiaz-gly-betadcph

7016: tolhs-oxadiaz-bala-suabu

7017: bhs-24thioph-ala-beta34meoph

7018: tolhs-24thiaz-bala-betabnaphth

7019: ibhs-25methiaz-gly-zdapee

7020: tolhs-24thiaz-bala-betacbph

7021: bhs-25thiaz-bala-betahni

7022: ibhs-oxadiaz-bala-betaheph

7023: phhs-25thiaz-bala-betapbiph

7024: ibhs-25oxaz-gly-betafu3

7025: tolhs-24thioph-bala-betadcph

7026: 2py-me25thiaz-bala-beta34meoph

7027: tolhs-ithiadiaz-gly-betaomebendi

7028: tolhs-24thiaz-bala-psdapch

7029: phhs-nme35pyr-bala-beta23meoph

7030: bhs-24thioph-gly-betadcphch

7031: phhs-nme35pyr-gly-betafph

7032: tolhs-24thioph-bala-betadcphtb

7033: bhs-nme35pyr-bala-betadmph

7034: bhs-oxadiaz-gly-betadcphtb

7035: phhs-ithiadiaz-gly-betapyr

7036: dhim-24thiaz-gly-betameph

7037: bgua-24thiaz-gly-betameph

7038: bhs-24thiaz-ala-betapy

7039: tolhs-24thiaz-bala-betaet

7040: ibhs-25thiaz-gly-betadbph

01/283/02 / PB

7041: 2py-26py-gly-betaanaphth 7042: bhs-25oxaz-bala-betadhbfu 7043: phhs-25oxaz-gly-betamethi

7044: bim-24im-gly-psdap

7045: tolhs-25oxaz-gly-betadhbfu 7046: gua-24oxaz-gly-betahb 7047: phhs-oxadiaz-bala-betaph 7048: ibhs-24thioph-bala-betaomebendi 7049: bhs-24thiaz-ala-beta3quin 7050: bhs-25oxaz -bala-beta34meoph 7051: ibhs-25methiaz-gly-beta4bph 7052: bhs-nme35pyr-bala-betapbiph 7053: phhs-25methiaz-bala-psdap 7054: bhs-25methiaz-bala-betahcbph 7055: bhs-oxadiaz-70adu-70adu3-glyadiaz-70ad : phhs-oxadiaz-bala-betaanaphth 7057: 2py-42nmeim-gly-zdap 7058: bhs-53pyrazo-leu-betadcph 7059: ibhs-25oxaz-bala-betahcbph 7060: gua-24thiaz-gly-betaol 7061: ibhs-nme35pyr bala-aspaba 7062: impy-42nmeim-gly-betathioph 7063: tolhs-24thioph-bala-betahph 7064: bhs-24thiaz-bala-betamesu 7065: phhs-nme35pyr-gly-betathio3 7066: 2py-24thioph-bala-betapy 7067: phhs-25thiaz-gly-betadcphch 7068: phhs-ithiadiaz-gly-betabdimo 7069: bim-me24thioph-ala-betadcph 7070: phhs-25methiaz-bala-zdaptb 7071: tolhs-25oxaz-gly-betafbph

01/283/02 / PB

268

7072: bgua-25thiaz-gly-betameph

7073: thazep-25thioph-gly-betadcph

7074: 2py-me24oxaz-gly-zdap

7075: tolhs-24thioph-gly-betadtrif

7076: tolhs-ithiadiaz-gly-beta13bendi

7077: bhs-me25thioph-bala-psdap

7078: ibhs-nme35pyr-bala-betampy

7079: phhs-25oxaz-gly-betahni

7080: tolhs-24thioph-gly-betambiph

7081: 2py-25thiaz-hphe-psdap

7082: tolhs-25oxaz-bala-zdapch

7083: tolhs-nme35pyr-bala-beta3quin

7084: ibhs-25oxaz-bala-betahmph

7085: phhs-nme35pyr-gly-betadcphtb

7086: bhs-nme35pyr-gly-betadmph

7087: phhs-25methiaz-gly-betadmph

7088: ibhs-nme35pyr-gly-beta3quin

7089: ibhs-24thiaz-bala-betaibph

7090: bhs-25oxaz-bala-busu2be

7091: dhim-42pym-gly-zdap

7092: tolhs-25methiaz-bala-betatos

7093: phhs-nme35pyr-gly-beta13bendi

7094: bhs-24thioph-gly-betabph

7095: tolhs-oxadiaz-bala-betaphethioa

7096: ibhs-nme35pyr-gly-betathiome

7097: bhs-oxadiaz-bala-betamesu

7098: bhs-oxadiaz-gly-zdapee

7099: phhs-oxadiaz-gly-beta3quin

7100: ibhs-25methiaz-gly-betaipr

7101: ibhs-nme35pyr-bala-betaphethioa

7102: gua-24oxaz-gly-betaol

01/283/02 / PB

269

7103: tolhs-24thiaz-bala-betapyee

7104: bhs-ithiadiaz-nmgly-betacthioph

7105: phhs-oxadiaz-gly-betadcphtb

7106: tolhs-ithiadiaz-gly-betabnaphth

7107: ibhs-25oxaz-bala-betabmph

7108: bim-52thiaz-ala-psdap

7109: tolhs-25methiaz-gly-betamesu

7110: hyd-25oxaz-gly-betapy

7111: bhs-24thioph-bala-betapyee

7112: 2py-26py-ala-betameph

7113: bim-25methiaz-gly-aspbzla

7114: ibhs-nme35pyr-gly-betadmph

7115: bim-25thiaz-bala-betadcph

7116: tolhs-24thioph-gly-betatrif

7117: phhs-24thiaz-gly-betamethioph

7118: tolhs-me24thiaz-ala-betadcph

7119: phhs-oxadiaz-gly-betadito

7120: tolhs-ithiadiaz-gly-beta34meoph

7121: bhs-ithiadiaz-gly-zdaptb

7122: impy-24thioph-bala-betah35dc

7123: ibhs-25oxaz-bala-betadbph

7124: 2py-25thioph-gly-betameph

7125: bim-25methiaz-bala-betahc

7126: tolhs-me24thioph-gly-betaph 7127: tolhs-oxadiaz-gly-betaftrif

7128: ibhs-oxadiaz-gly-betathiobe

7129: tolhs-nme35pyr-gly-beta35dbph

7130: ibhs-nme35pyr-bala-ibsdap

7131: phhs-25oxaz-gly-betahmph

7132: bhs-oxadiaz-ala-betadhbfu

7133: impy-25thiaz-bala-betamethi

01/283/02 / PB

270

7134: ibhs-nme35pyr-bala-psdapch

7135: bhs-me25oxaz-ala-psdap

7136: bhs-ithiadiaz-nmgly-betahph

7137: bhs-oxadiaz-ala-betacthioph

7138: dhim-26py-phe-zdap

7139: bhs-24thioph-bala-betah35dc

7140: bhs-oxadiaz-bala-busu2be

7141: ibhs-25thiaz-gly-betaol

7142: bhs-oxadiaz-bala-betatbuph

7143: ibhs-nme35pyr-bala-betaipro

7144: bhs-me24thioph-leu-betaph

7145: ibhs-24thioph-gly-betampy

7146: phhs-oxadiaz-gly-psdap

7147: bhs-nme35pyr-gly-betamethioph

7148: bhs-25methiaz-bala-betathio3

7149: tolhs-24thiaz-bala-betainyl

7150: phhs-me25thioph-leu-beta34meoph

7151: 2py-me25thiaz-leu-psdap

7152: bhs-ithiadiaz-bala-aspbzla

7153: thpy-42nmeim-gly-psdap

7154: phhs-24thioph-gly-betainyl

7155: phhs-25methiaz-gly-betambiph

7156: ibhs-nme35pyr-gly-suabu

7157: bhs-oxadiaz-gly-betameph

7158: impy-24thiaz-gly-beta34meoph

7159: ibhs-nme35pyr-bala-betatbuph

7160: ibhs-24thioph-gly-busu2be

7161: bhs-24thioph-gly-betamesu

7162: tolhs-ithiadiaz-gly-zdap

7163: gua-25thiaz-gly-betameph

7164: ibhs-nme35pyr-gly-betacthioph

01/283/02 / PB

271

7165: bhs-24im-leu-psdap

7166: ibhs-24thiaz-bala-betacbph

7167: bhs-oxadiaz-bala-betahni

7168: tolhs-24thiaz-gly-betapyee

7169: ibhs-24thioph-bala-betapyr

7170: phhs-nme35pyr-gly-beta34meoph

7171: bhs-24thiaz-ala-betadito

7172: bim-42nmeim-bala-betabthioph

7173: bhs-24thiaz-bala-betacbph

7174: ibhs-nme35pyr-bala-betabph

7175: phhs-ithiadiaz-gly-betahmph

7176: tolhs-ithiadiaz-bala-psdaptb

7177: ibhs-25oxaz-bala-betadmoph

7178: tolhs-me24oxaz-ala-zdap

7179: ibhs-ithiadiaz-bala-betahcbph

7180: ibhs-25methiaz-bala-betathioph

7181: tolhs-25methiaz-gly-psdaptb

7182: tolhs-25oxaz-bala-betaph

7183: bhs-25thiaz-ala-betadmph

7184: bhs-24oxaz-bala-betadcph

7185: ibhs-24thioph-bala-psdapee

7186: bhs-ithiadiaz-gly-betapyr

7187: bhs-42nmeim-bala-betadito

7188: bim-24thiaz-bala-asppha

7189: bhs-24thiaz-gly-beta23meoph

7190: bhs-nme35pyr-nmgly-betacph

7191: bhs-24oxaz-leu-betapy

7192: impy-24thiaz-bala-betaphethioa

7193: phhs-ithiadiaz-gly-asppha

7194: phhs-25methiaz-gly-betapyr

7195: phhs-24thioph-gly-betaph

01/283/02 / PB

272

7196: dhim-26py-ala-psdap

7197: ibhs-24thioph-bala-betafu3

7198: ibhs-ithiadiaz-bala-betahb

7199: bhs-ithiadiaz-gly-betaomebendi

7200: phhs-25oxaz-bala-betabenfu

7201: tolhs-25thiaz-bala-betaipro

7202: phhs-25oxaz-bala-beta13bendi

7203: tolhs-oxadiaz-gly-betahc

7204: ibhs-25thiaz-bala-betadcphtb

7205: bhs-me24oxaz-bala-psdap

7206: ibhs-nme35pyr-bala-zdapee

7207: phhs-24thioph-bala-betainyl

7208: ibhs-24thioph-gly-zdap

7209: bhs-25methiaz-ala-betaanaphth

7210: tolhs-24thioph-gly-betapyee

7211: phhs-25thiaz-bala-ibsdap

7212: tolhs-24thiaz-gly-betabenfu

7213: bhs-oxadiaz-ala-beta23meoph

7214: bhs-25methiaz-ala-beta3quin

7215: phhs-25thiaz-gly-betaimide

7216: ibhs-nme35pyr-bala-beta34dcph

7217: ibhs-oxadiaz-gly-betahcbph

7218: ibhs-nme35pyr-gly-aspbzla

7219: 2py-25oxaz-ala-betapy

7220: gua-24thiaz-gly-betahdbph

7221: phhs-nme35pyr-bala-betaph

7222: bhs-nme35pyr-bala-betahdbph

7223: bhs-24thiaz-gly-betafph

7224: tolhs-25thiaz-bala-zdapch

7225: ibhs-24thiaz-gly-betapy

7226: tolhs-nme35pyr-bala-betadito

01/283/02 / PB

273

7227: phhs-25thiaz-bala-betafluo

7228: tolhs-24thiaz-gly-betaimide

7229: bhs-oxadiaz-gly-betafphe

7230: tolhs-me24thiaz-gly-betaph

7231: bim-53pyrazo-leu-psdap

7232: thazep-26py-gly-betainyl

7233: tolhs-nme35pyr-bala-betafluo

7234: tolhs-25methiaz-bala-beta13bendi

7235: bhs-25thioph-bala-psdap

7236: 2 pmhs-24thiaz-gly-betathiome

7237: 2py-25oxaz-gly-betabthioph

7238: bhs-25thiaz-bala-betaoxope

7239: bhs-25oxaz-gly-betapych

7240: ibhs-25oxaz-gly-betahmph

7241: bhs-25oxaz-gly-betaet

7242: gua-26py-gly-betainyl

7243: bim-53pyrazo-gly-betadcph

7244: 2py-25oxaz-bala-aspaba

7245: bhs-me25thioph-bala-betadcph

7246: ibhs-25methiaz-bala-betabpy

7247: bhs-24oxaz-gly-psdap

7248: bhs-25thiaz-bala-zdapch

7249: tolhs-24thiaz-bala-betaimide

7250: ibhs-24thioph-gly-beta34meoph

7251: tolhs-25methiaz-bala-betaipr

7252: bhs-nme35pyr-bala-betadcphee

7253: tolhs-oxadiaz-gly-betabph

7254: gua-24thiaz-gly-betaheph

7255: tolhs-nme35pyr-gly-zdaptb

7256: ibhs-25oxaz-bala-betahmo

7257: bim-me25oxaz-leu-beta34meoph

01/283/02 / PB

7258: 2py-24im-ala-betapy

7259: bhs-24thiaz-nmgly-betainyl

7260: phhs-25thiaz-bala-betaipr

7261: bhs-24thiaz-gly-asppha

7262: 2py-53pyrazo-leu-betadcph

7263: bhs-me24thioph-bala-betadcph

7264: dhim-26py-gly-betameph

7265: bhs-nme35pyr-ala-betamesu

7266: ibhs-25oxaz-gly-betabpy

7267: bhs-thiadiaz-gly-psdap

7268: bim-25methiaz-leu-zdap

7269: phhs-24thiaz-bala-betabnaphth

7270: ibhs-nme35pyr-gly-betadmoph

7271: 2py-25thiaz-bala-betaheph

7272: dhpyrr-24thioph-gly-betapy

7273: phhs-me24thiaz-gly-betadcph

7274: tolhs-24thioph-gly-betahc

7275: bhs-24thiaz-gly-betahdbph

7276: bim-25oxaz-gly-betaph

7277: bim-nme35pyr-bala-aspbzla

7278: tolhs-nme35pyr-gly-zdap

7279: bhs-25methiaz-bala-psdapee

7280: 2py-me24thiaz-leu-betapy

7281: bhs-oxadiaz-nmgly-beta3quin

7282: tolhs-24thiaz-gly-betahph

7283: bhs-25thiaz-phg-betameph

7284: tolhs-me25oxaz-leu-betapy

7285: 2py-24thioph-bala-betafluo

7286: tolhs-25oxaz-bala-betaheph

7287: ibhs-25thiaz-bala-betabenfu

7288: phhs-nme35pyr-gly-ibsdap

274

01/283/02 / PB

7289: ibhs-24thioph-bala-betamethi

7290: ibhs-24thioph-bala-betaphethio

7291: ibhs-24thioph-gly-suabu

7292: bhs-25methiaz-bala-betabph

7293: 2py-25methiaz-bala-betabnaphth

7294: tolhs-24thioph-bala-betahni

7295: bhs-nme35pyr-gly-betainyl

7296: ibhs-25methiaz-gly-betadito

7297: impy-25methiaz-gly-betacbph

7298: ibhs-oxadiaz-gly-betafphe

7299: bhs-oxadiaz-gly-betambiph

7300: bhs-nme35pyr-ala-betathio3

7301: bhs-25methiaz-gly-betapytb

7302: 2py-25oxaz-bala-zdap

7303: phhs-24thiaz-gly-betahmo

7304: bim-24thioph-ala-psdap

7305: bim-me24oxaz-ala-betadcph

7306: bhs-24thioph-gly-betafu2

7307: ibhs-25thiaz-gly-betapytb

7308: ibhs-24thioph-bala-betameph

7309: phhs-oxadiaz-gly-betafu3

7310: ibhs-25thiaz-gly-betambiph

7311: ibhs-oxadiaz-gly-betathioph

7312: phhs-25methiaz-bala-betahbcph

7313: bim-24thiaz-gly-zdap

7314: bhs-25fur-bala-betadcph

7315: tolhs-oxadiaz-bala-betatrif

7316: bhs-24im-bala-betadcph

7317: tolhs-25methiaz-bala-zdap

7318: phhs-ithiadiaz-gly-betadcphee

7319: ibhs-25methiaz-bala-betaftrif

275

01/283/02 / PB

276

7320: tolhs-nme35pyr-gly-betapy

7321: phhs-25methiaz-gly-betabmph

7322: dhthi-42nmeim-bala-psdap

7323: tolhs-24thiaz-bala-beta34dcph

7324: tolhs-me25thiaz-leu-zdap

7325: 2py-me25thiaz-bala-betaph

7326: bhs-25methiaz-ala-zdap

7327: bhs-24thioph-nmgly-betadmph

7328: bhs-24thiaz-leu-zdap

7329: ibhs-24thiaz-bala-betabdimo

7330: tolhs-25oxaz-gly-psdaptb

7331: phhs-me24thioph-ala-beta34meoph

7332: bim-25thiaz-phg-zdap

7333: ibhs-24thiaz-gly-betapym

7334: bim-me25thiaz-ala-betapy

7335: 2py-42oxaz-bala-betapy

7336: bim-42oxaz-gly-betapy

7337: bhs-25oxaz-gly-betapytb

7338: bhs-25oxaz-gly-betapyee

7339: gua-42pym-gly-betabdimo

7340: bhs-26py-gly-betameph

7341: impy-26py-gly-psdap

7342: bhs-25oxaz-bala-betabediox

7343: tolhs-oxadiaz-bala-zdapee

7344: bhs-nme35pyr-gly-betathiobe

7345: tolhs-25methiaz-gly-betaomebendi

7346: ibhs-24thioph-bala-betampy

7347: ibhs-24thiaz-bala-betapbiph

7348: ibhs-24thioph-bala-psdapch

7349: phhs-24thiaz-bala-betaet

7350: bhs-25methiaz-bala-betaoxaz

01/283/02 / PB

277

7351: bhs-me24thioph-leu-betadcph

7352: 2py-25thioph-bala-betadcph

7353: tolhs-ithiadiaz-gly-betathiobe

7354: bhs-25methiaz-bala-betathiome

7355: bhs-oxadiaz-gly-betaoxope

7356: bhs-24thiaz-bala-betabnaphth

7357: phhs-nme35pyr-bala-betahph

7358: ibhs-25thiaz-gly-zdaptb

7359: bhs-oxadiaz-ala-betahph

7360: ibhs-42nmeim-gly-betameph

7361: ibhs-24thioph-bala-betaol

7362: tolhs-24thioph-bala-betah35dc

7363: ibhs-24thiaz-gly-betadcphtb

7364: bhs-25thiaz-gly-betabenfu

7365: tolhs-ithiadiaz-bala-betaoxope

7366: ibhs-oxadiaz-gly-betaheph

7367: bhs-24thiaz-ala-betacthioph

7368: ibhs-24thioph-gly-betapbiph

7369: bhs-oxadiaz-nmgly-betathio3

7370: bim-me25thiaz-ala-betaph

7371: ibhs-oxadiaz-gly-betahph

7372: gua-42pym-gly-betampy

7373: tolhs-25oxaz-gly-betafu2

7374: phhs-nme35pyr-bala-betaoxope

7375: ibhs-nme35pyr-bala-betaimide

7376; bhs-25oxaz-gly-psdapee

7377: bhs-25thiaz-nmgly-betacph

7378: tolhs-24thioph-bala-aspbzla

7379: ibhs-25methiaz-gly-psdapee

7380: tolhs-25thiaz-gly-betafph

7381: phhs-ithiadiaz-gly-betaphethio

01/283/02 / PB

278

7382: ibhs-ithiadiaz-bala-betafu3

7383: ibhs-25oxaz-bala-betadcphee

7384: phhs-25methiaz-gly-betaanaphth

7385: phhs-ithiadiaz-gly-zdapee

7386: bim-ithiadiaz-gly-aspibua

7387: phhs-25oxaz-bala-betaheph

7388: tolhs-25methiaz-gly-zdaptb

7389: bhs-oxadiaz-ala-betainyl

7390: tolhs-24thioph-gly-ibsdap

7391: 2py-nme35pyr-gly-zdap

7392: bim-24thiaz-bala-betahc

7393: 2py-me25thioph-bala-zdap

7394: imhs-25oxaz-bala-psdap

7395: bhs-24thioph-bala-betahni

7396: tolhs-24thioph-gly-betaet

7397: ibhs-25thiaz-gly-betahdbph

7398: phhs-nme35pyr-gly-psdapee

7399: phhs-oxadiaz-gly-betahbcph

7400: hyd-24thioph-bala-betameph

7401: phhs-25thiaz-bala-busu2be

7402: tolhs-24thioph-gly-betahph

7403: 2py-24thioph-bala-betaheph

7404: tolhs-nme35pyr-bala-beta13bendi

7405: bhs-ithiadiaz-gly-betahb

7406: bhs-oxadiaz-bala-betaibph

7407: ibhs-25methiaz-gly-betafphe

7408: phhs-24thiaz-gly-betahph

7409: 2py-24thioph-leu-psdap

7410: phhs-nme35pyr-bala-betadcphtb 7411: ibhs-24thiaz-gly-betadcphch

7412: 2py-24thiophme-ala-betapy at ,, νί

01/283/02 / PB

279

7413: bhs-24thioph-bala-psdaptb

7414: ibhs-25methiaz-bala-betabenfu

7415: 2py-ithiadiaz-leu-betapy

7416: bim-42nmeim-leu-psdap

7417: gua-42pym-gly-betahmph

7418: phhs-25methiaz-gly-betabpy

7419: tolhs-24thioph-gly-betaamibe

7420: bhs-25oxaz-bala-psdapee

7421: 2 pmhs-25methiaz-bala-betamethioph

7422: dimethpym-24thiaz-gly-betahdcph

7423: bhs-24thiaz-bala-betah35dc

7424: tolhs-24thioph-bala-betabenfu

7425: bim-24thioph-ala-betadcph

7426: phhs-25methiaz-bala-betamesu

7427: bhs-nme35pyr-bala-betathiobe

7428: phhs-ithiadiaz-gly-zdap

7429: phhs-ithiadiaz-bala-betameph

7430: tolhs-nme35pyr-bala-betambiph

7431: bhs-35fur-leu-betapy

7432: phhs-25thiaz-gly-betaanaphth

7433: bhs-me24thiaz-gly-betaph

7434: bhs-25methiaz-bala-betameph

7435: ibhs-nme35pyr-bala-psdaptb

7436: phhs-me24thioph-bala-beta34meoph

7437: bhs-25thiaz-gly-betaomebendi

7438: bhs-25thiaz-gly-betadbph

7439: bhs-25methiaz-gly-betamethi

7440: gua-24oxaz-gly-betaet

7441: phhs-24thioph-gly-suabu

7442: bhs-42nmeim-bala-beta35dbph

7443: ibhs-25thiaz-gly-betahmo

01/283/02 / PB

280

7444: bhs-24thiaz-gly-zdapee

7445: ibhs-24thiaz-bala-betahdbph

7446: ibhs-24thioph-gly-betahb

7447: bim-25oxaz-gly-betadtrif

7448: bhs-24thioph-ala-betahph

7449: bhs-25oxaz-leu-psdap

7450: bhs-nme35pyr-bala-betainyl

7451: bhs-ithiadiaz-ala-beta3quin

7452: phhs-24thiaz-bala-betahdcph

7453: bim-me25thiaz-leu-betapy

7454: 2py-25thiaz-gly-betainyl

7455: tolhs-25oxaz-gly-beta13bendi

7456: tolhs-24thiaz-bala-beta4bph

7457: tolhs-ithiadiaz-bala-betampy

7458: bhs-25oxaz-gly-betafphe

7459: tolhs-ithiadiaz-bala-betahmph

7460: ibhs-25thiaz-gly-betaphethioa

7461: ibhs-24thioph-bala-betacph

7462: bhs-25methiaz-bala-betaamibe

7463: phhs-me25thioph-leu-psdap

7464: 2py-me25thiaz-leu-beta34meoph

7465: ibhs-ithiadiaz-bala-betaamibe

7466: phhs-oxadiaz-bala-betaoxaz

7467: phhs-nme35pyr-gly-betaphethioa

7468: bhs-24thiaz-gly-betabpy

7469: tolhs-ithiadiaz-bala-betamethioph

7470: bim-24oxaz-leu-psdap

7471: bhs-thiadiaz-leu-psdap

7472: 2py-oxadiaz-gly-aspaba

7473: 2py-42nmeim-gly-psdap

7474: impy-25methiaz-gly-betathiobe

01/283/02 / PB

281

7475: tolhs-25oxaz-bala-betampy

7476: ibhs-25oxaz-bala-aspbzla

7477: ibhs-25thiaz-bala-betaamibe

7478: phhs-24thioph-gly-betabmph

7479: ibhs-25thiaz-bala-betaet

7480: ibhs-25methiaz-bala-betaoxope

7481: bhs-nme35pyr-bala-betaibph

7482: tolhs-25oxaz-gly-betapbiph

7483: 2py-25methiaz-bala-suabu

7484: tolhs-ithiadiaz-gly-betadcph

7485: 2 pmhs-42nmeim-gly-betaoxaz

7486: ibhs-25methiaz-bala-psdaptb

7487: bhs-25methiaz-bala-betaomebendi

7488: impy-25oxaz-gly-beta23meoph

7489: bhs-nme35pyr-gly-psdaptb

7490: bhs-24thioph-gly-betacph

7491: bhs-25oxaz-bala-aspibua

7492: tolhs-nme35pyr-bala-zdapee

7493: bhs-25methiaz-bala-betamesu

7494: 2py-42oxaz-leu-betadcph

7495: ibhs-25thiaz-gly-betadmoph

7496: bhs-nme35pyr-bala-betaipro

7497: bim-42nmeim-gly-betainyl

7498: phhs-nme35pyr-gly-betaph

7499: tolhs-25methiaz-bala-betafph

7500: tolhs-24thioph-bala-psdap

7501: bhs-25thioph-ala-betameph

7502: tolhs-25oxaz-bala-betaoxaz

7503: phhs-25thiaz-bala-betahmofu

7504: bim-24thioph-gly-asppha

7505: phhs-25oxaz-bala-betatbuph

01/283/02 / PB

282

7506: bhs-oxadiaz-ala-betamesu

7507: ibhs-24thioph-gly-betabthioph

7508: 2 pmhs-24thiaz-bala-betahph

7509: phhs-25oxaz-gly-betabthioph

7510: phhs-24thioph-bala-betaoxope

7511: bhs-ithiadiaz-bala-ibsdap

7512: ibhs-25thiaz-gly-zdapee

7513: bhs-25oxaz-bala-betafbph

7514: tolhs-25oxaz-gly-betabthioph

7515: bhs-me25thioph-bala-beta34meoph

7516: impy-25methiaz-gly-betaipr

7517: phhs-25thiaz-gly-betadcphtb

7518: bhs-24thiaz-bala-betaipr

7519: tolhs-24thioph-gly-psdapch

7520: bhs-me24oxaz-gly-betapy

7521: phhs-nme35pyr-bala-betathio3

7522: bhs-nme35pyr-gly-betabenfu

7523: phhs-25methiaz-bala-betadito

7524: ibhs-nme35pyr-bala-betadcphtb

7525: tolhs-24thioph-gly-aspaba

7526: 2py-35thioph-bala-psdap

7527: bim-me25thiaz-bala-psdap

7528: gua-25thioph-gly-beta3quin

7529: gua-42pym-gly-betathiome

7530: phhs-25methiaz-gly-beta23meoph

7531: phhs-25thiaz-gly-betadbph

7532: tolhs-24thiaz-gly-ibsdap

7533: bim-25oxaz-ala-betadcph

7534: 2py-25thiaz-bala-psdap

7535: phhs-ithiadiaz-bala-betahbcph

7536: ibhs-ithiadiaz-gly-betahmo

01/283/02 / PB

283

7537: bhs-25oxaz-gly-betadito

7538: 2 pmhs-25oxaz-gly-betacthioph

7539: bhs-me25thiaz-ala-beta34meoph

7540: ibhs-25thiaz-gly-betahmph

7541: bhs-nme35pyr-bala-betahc

7542: tolhs-24thioph-bala-busu2be

7543: ibhs-nme35pyr-gly-betahph

7544: bim-24thioph-gly-betaanaphth

7545: phhs-oxadiaz-bala-csdap

7546: phhs-25thiaz-gly-psdaptb

7547: bim-24oxaz-leu-betadcph

7548: phhs-24thiaz-bala-betahc

7549: phhs-25methiaz-bala-aspaba

7550: tolhs-25oxaz-gly-betacph

7551: bhs-24thiaz-gly-betahni

7552: ibhs-25oxaz-gly-busu2be

7553: bhs-24thiaz-bala-betahmofu

7554: phhs-25oxaz-bala-betaipro

7555: impy-24thiaz-gly-betacbph

7556: ibhs-25methiaz-bala-betafph

7557: tolhs-24thiaz-gly-betathiobe

7558: ibhs-ithiadiaz-bala-beta4bph

7559: bhs-24thiaz-bala-betambiph

7560: gua-24thiaz-gly-betathiobe

7561: bgua-24thiaz-gly-betapy

7562: tolhs-ithiadiaz-bala-betathioph

7563: bhs-42pym-gly-betacph

7564: phhs-ithiadiaz-bala-betadito

7565: bhs-nme35pyr-bala-aspaba

7566: bhs-24thioph-bala-betaipr

7567: ibhs-24thioph-bala-betaanaphth

01/283/02 / PB

284

7568: dhpyrr-26py-gly-betapy

7569: tolhs-25methiaz-bala-betaomebendi

7570: bhs-ithiadiaz-bala-betahph

7571: bhs-nm35pyr-gly-beta4bph

7572: bim-oxadiaz-gly-aspbzla

7573: phhs-25thiaz-bala-betabnaphth

7574: phhs-24thioph-gly-betaipro

7575: phhs-25thiaz-gly-beta4bph

7576: ibhs-25thiaz-bala-betathio3

7577: ibhs-25thiaz-bala-betabpy

7578: phhs-oxadiaz-bala-beta34dcph

7579: bhs-25oxaz-bala-betaomebendi

7580: tolhs-24thiaz-gly-betamethioph

7581: 2py-42nmeim-bala-betapbiph

7582: ibhs-oxadiaz-gly-beta35dbph

7583: bhs-nme35pyr-bala-beta23meoph

7584: tolhs-nme35pyr-gly-betabthioph

7585: tolhs-oxadiaz-gly-betabmph

7586: bhs-25thiaz-ala-betadcph

7587: 2py-42pym-ala-betameph

7588: bhs-24thiaz-bala-betameph

7589: ibhs-25thiaz-gly-betaibph

7590: tolhs-ithiadiaz-gly-betambiph

7591: bhs-triaz-leu-betadcph

7592: tolhs-25oxaz-gly-betaphethio

7593: tolhs-24thioph-bala-betahdcph

7594: tolhs-25oxaz-gly-betafluo

7595: bhs-me25oxaz-ala-beta34meoph

7596: bhs-24thioph-bala-zdap

7597: ibhs-oxadiaz-gly-betaipr

7598: tolhs-25methiaz-bala-betahdbph

01/283/02 / PB 285

7599: bhs-me25thioph-leu-zdap

7600: tolhs-24thiaz-gly-betadmoph

7601: phhs-25thiaz-gly-betaftrif

7602: tolhs-25methiaz-gly-betahmofu

7603: bhs-oxadiaz-bala-betaphethioa

7604: phhs-25thiaz-bala-betadmph

7605: phhs-24thiaz-gly-betapych

7606: bhs-me24thiaz-gly-beta34meoph

7607: bhs-24thioph-gly-betahni

7608: bhs-25thiaz-gly-betadcphch

7609: tolhs-oxadiaz-bala-betamethi

7610: ibhs-25methiaz-gly-betameph

7611: phhs-25oxaz-gly-beta4bph

7612: tolhs-24thiaz-gly-aspibua

7613: 2py-24thiaz-gly-betatbuph

7614: phhs-oxadiaz-gly-betah35dc

7615: phhs-ithiadiaz-gly-betapy

7616: bhs-25oxaz-bala-betabthioph

7617: tolhs-oxadiaz-gly-betathiobe

7618: bhs-25thiaz-gly-betahdbph

7619: ibhs-25oxaz-gly-betahc

7620: 2py-35thioph-bala-betadcph

7621: bim-me24thiaz-leu-beta34meoph

7622: tolhs-24thiaz-bala-betafphe

7623: 2py-26py-phg-zdap

7624: bhs-24thioph-gly-beta34meoph

7625: tolhs-oxadiaz-bala-betamethioph

7626: phhs-nme35pyr-bala-betamethi

7627: bhs-ithiadiaz-ala-betahph

7628: phhs-25oxaz-gly-betafu2

7629: bhs-nme35pyr-bala-zdapch

01/283/02 / PB

286

7630: bhs-24thioph-gly-aspaba

7631: tolhs-25thiaz-gly-betadmoph

7632: tolhs-24thioph-bala-betatos

7633: bhs-25oxaz-bala-betadito

7634: bhs-53pyrazo-leu-psdap

7635: ibhs-oxadiaz-gly-betaipro

7636: 2py-12me35pyr-gly-asppha

7637: thpy-25thiaz-gly-betadcph

7638: gua-25thiaz-gly-betaftrif

7639: bim-nme35pyr-bala-zdap

7640: phhs-25thiaz-gly-betapym

7641: bim-42nmeim-ala-psdap

7642: bhs-24thioph-bala-beta35dbph

7643: tolhs-25oxaz-bala-betafph

7644: tolhs-25methiaz-gly-betaimide

7645: phhs-me25oxaz-bala-beta34meoph

7646: bim-me25thioph-leu-betapy

7647: phhs-24thiaz-gly-betaheph

7648: ibhs-25oxaz-bala-csdap

7649: tolhs-me24oxaz-leu-zdap

7650: bhs-oxadiaz-bala-betah35dc

7651: bhs-24thioph-nmgly-beta3quin

7652: tolhs-25oxaz-bala-psdaptb

7653: bhs-nme35pyr-gly-betaibph

7654: bhs-oxadiaz-bala-betafluo

7655: dimethpym-25oxaz-bala-betapy

7656: tolhs-nme35pyr-bala-betafu2

7657: phhs-nme35pyr-bala-betatbuph

7658: bhs-25oxaz-bala-psdap

7659: bim-oxadiaz-gly-aspaba

7660: tolhs-ithiadiaz-gly-betabdimo

01/283/02 / PB

287

7661: bhs-24thioph-bala-betafphe

7662: tolhs-25oxaz-gly-busu2be

7663: bim-35pyrazo-ala-zdap

7664: impy-24thiaz-bala-busu2be

7665: gua-24thiaz-gly-betatrif

7666: phhs-me25oxaz-gly-betadcph

7667: phhs-me24thioph-leu-zdap

7668: phhs-24thioph-gly-betadcph

7669: tolhs-ithiadiaz-bala-betatos

7670: bhs-ithiadiaz-gly-betafphe

7671: phhs-ithiadiaz-bala-betadcphtb

7672: bhs-24thioph-bala-betahbcph

7673: bhs-ithiadiaz-gly-zdapch

7674: bim-42nmeim-ala-zdap

7675: tolhs-25methiaz-gly-betadcphtb

7676: tolhs-nme35pyr-gly-betafu3

7677: bhs-24thiaz-phg-betapy

7678: ibhs-ithiadiaz-gly-suabu

7679: dhpyrr-25oxaz-bala-betadcph

7680: ibhs-oxadiaz-gly-betapbiph

7681: ibhs-25oxaz-bala-betathiome

7682: hts-24oxaz-gly-betapy

7683: tolhs-25oxaz-gly-psdapch

7684: phhs-25methiaz-gly-beta13bendi

7685: bim-25thiaz-bala-zdap

7686: gua-42pym-gly-betahdcph

7687: phhs-25oxaz-gly-betaanaphth

7688: phhs-ithiadiaz-gly-betathio3

7689: bhs-nme35pyr-gly-beta34meoph

7690: bhs-25thiaz-gly-betafu3

7691: bim-24thiaz-ala-betapy

01/283/02 / PB

288

7692: tolhs-ithiadiaz-gly-betabpy

7693: ibhs-25thiaz-bala-beta4bph

7694: tolhs-nme35pyr-bala-betadmph

7695: ibhs-24thioph-gly-betathio3

7696: bhs-24thioph-gly-betainyl

7697: ur-42nmeim-gly-psdap

7698: phhs-25oxaz-bala-betacthioph

7699: bim-24thioph-bala-aspaba

7700: bim-me24oxaz-bala-betapy

7701: ibhs-nme35pyr-bala-betadmph

7702: ibhs-24thiaz-bala-betadcph

7703: tolhs-25oxaz-gly-betabdimo

7704: bhs-nme35pyr-gly-beta23meoph

7705: bhs-nme35pyr-bala-betafu3

7706: cima-42pym-gly-betainyl

7707: tolhs-oxadiaz-bala-betadcphtb

7708: 2py-me24thioph-ala-zdap

7709: phhs-25oxaz-bala-betaet

7710: ibhs-oxadiaz-gly-betambiph

7711: bhs-ithiadiaz-bala-betaet

7712: gua-24oxaz-gly-betadcph

7713: tolhs-25methiaz-gly-betaph

7714: bhs-25thiaz-gly-betacph

7715: impy-25oxaz-bala-betaoxaz

7716: ibhs-oxadiaz-bala-beta35dbph

7717: phhs-ithiadiaz-bala-beta34meoph

7718: 2py-35thioph-gly-psdap

7719: tolhs-nme35pyr-bala-betadcphtb

7720: dhim-52thiaz-gly-betainyl

7721: bhs-25methiaz-nmgly-betathioph

7722: tolhs-24thioph-gly-betaimide

01/283/02 / PB

289

7723: bhs-25methiaz-bala-betaheph

7724: phhs-nme35pyr-bala-betahdbph

7725: phhs-25thiaz-gly-psdap

7726: bhs-ithiadiaz-gly-betadcph

7727: tolhs-nme35pyr-bala-betabpy

7728: ibhs-25thiaz-bala-psdaptb

7729: 2py-25thiaz-gly-aspbzla

7730: phhs-25oxaz-gly-betabph

7731: phhs-25oxaz-gly-betamesu

7732: bhs-oxadiaz-ala-betabnaphth

7733: bhs-nme35pyr-bala-betafbph

7734: tolhs-24thioph-bala-betadito

7735: ibhs-25thiaz-bala-psdap

7736: tolhs-25thiaz-bala-betabdimo

7737: bhs-25thiaz-gly-zdapch

7738: phhs-me25thiaz-bala-betapy

7739: phhs-24thiaz-gly-betapbiph

7740: tolhs-oxadiaz-bala-betaphethio

7741: hs-26py-gly-betapy

7742: bhs-24thioph-gly-aspibua

7743: phhs-nme35pyr-bala-betabdimo

7744: gua-24thiaz-gly-betathio3

7745: bhs-25methiaz-gly-betabpy

7746: dhim-42pym-gly-psdap

7747: ibhs-25thiaz-gly-asppha

7748: tolhs-nme35pyr-gly-betathiobe

7749: 2py-me24oxaz-leu-psdap

7750: phhs-25thiaz-bala-zdaptb

7751: 2py-42pym-ala-betapy

7752: phhs-25methiaz-bala-betahdcph

7753: phhs-25oxaz-gly-psdapee

01/283/02 / PB

290

7754: ibhs-24thiaz-gly-betambiph

7755: phhs-oxadiaz-gly-zdap

7756: bhs-35thioph-leu-psdap

7757: tolhs-ithiadiaz-gly-betathioph

7758: bim-25fur-leu-zdap

7759: gua-24thiaz-gly-betadmph

7760: phhs-ithiadiaz-gly-betatrif

7761: gua-42pym-gly-betapy

7762: phhs-25oxaz-bala-betaol

7763: bim-oxadiaz-gly-zdap

7764: ibhs-oxadiaz-gly-betainyl

7765: bhs-25methiaz-bala-betadbph

7766: phhs-24thiaz-gly-betabdimo

7767: bhs-25thiaz-nmgly-beta23meoph

7768: bhs-25thiaz-gly-betathiome

7769: tolhs-me25thiaz-ala-betadcph

7770: bhs-me25oxaz-bala-psdap

7771: bhs-nme35pyr-bala-betadbph

7772: bhs-25methiaz-gly-betathioph

7773: bhs-24thioph-nmgly-beta34dcph

7774: ibhs-25methiaz-bala-betadmoph

7775: phhs-24thioph-bala-betaheph

7776: bhs-25oxaz-bala-betabph

7777: bhs-oxadiaz-ala-betahmph

7778: phhs-nme35pyr-bala-betaimide

7779: ibhs-oxadiaz-bala-betapym

7780: ibhs-25thiaz-gly-betafphe

7781: 2py-24thiaz-gly-psdap

7782: tolhs-24thiaz-gly-betathiome

7783: bhs-ithiadiaz-nmgly-betaoxaz

7784: thazep-24oxaz-gly-betapy

01/283/02 / PB

291

7785: phhs-oxadiaz-bala-psdap

7786: ibhs-25oxaz-gly-beta4bph

7787: phhs-25thiaz-gly-betapyee

7788: bhs-35thioph-gly-betapy

7789: 2py-35fur-1eu-psdap

7790: tolhs-24thioph-gly-aspibua

7791: tolhs-24thioph-bala-betaftrif

7792: bhs-25methiaz-gly-betahc

7793: tolhs-24thiaz-gly-psdapee

7794: bim-24thiaz-gly-betapy

7795: tolhs-25thiaz-bala-betaibph

7796: tolhs-me24thiaz-leu-betadcph

7797: 2py-me24oxaz-bala-beta34meoph

7798: bhs-nme35pyr-nmgly-beta13bendi

7799: phhs-25oxaz-gly-betafphe

7800: bhs-nme35pyr-bala-betahph

7801: impy-25thiaz-gly-zdap

7802: gua-24oxaz-gly-betafluo

7803: phhs-ithiadiaz-gly-betaheph

7804: bhs-42nmeim-leu-betadcph

7805: phhs-nme35pyr-bala-busu2be

7806: bim-thiadiaz-leu-psdap

7807: dhim-52thiaz-ala-zdap

7808: bhs-24thioph-gly-betahdbph

7809: nmhs-24oxaz-gly-betapy

7810: gua-42pym-gly-betahb

7811: tolhs-ithiadiaz-gly-betathiome

7812: 2py-24thioph-bala-aspbzla

7813: bhs-25oxaz-gly-betathiobe

7814: tolhs-me24oxaz-bala-psdap

7815: bhs-24thioph-gly-betahmph

01/283/02 / PB

292

7816: tolhs-nme35pyr-bala-csdap

7817: ibhs-25thiaz-gly-betamesu

7818: phhs-24thiaz-bala-ibsdap

7819: 2py-thiadiaz-gly-betadcph

7820: 2py-42oxaz-ala-betapy

7821: bhs-25thiaz-gly-psdapee

7822: bim-oxadiaz-ala-betadcph

7823: phhs-24thioph-bala-betadcphtb

7824: tolhs-25thiaz-gly-betampy

7825: ibhs-24thiaz-gly-betapych

7826: phhs-24thioph-gly-betamesu

7827: tolhs-me25thiaz-bala-psdap

7828: bim-25oxaz-bala-betadcph

7829: bhs-nme35pyr-gly-zdapch

7830: ibhs-25methiaz-gly-betaphethioa

7831: phhs-24thiaz-bala-aspaba

7832: tolhs-24thioph-bala-betahdbph

7833: bhs-me24thioph-leu-psdap

7834: phhs-25oxaz-gly-betathio3

7835: bhs-24thiaz-bala-beta4bph

7836: phhs-nme35pyr-gly-betatos

7837: ibhs-nme35pyr-bala-betaoxaz

7838: tolhs-24thioph-bala-betahbcph

7839: bhs-oxadiaz-gly-betahni

7840: phhs-25oxaz-bala-betaphethioa 7841: 2py-24thioph-bala-asppha

7842: tolhs-24thioph-gly-betaomebendi

7843: tolhs-25oxaz-bala-betabediox

7844: impy-24thioph-bala-betamesu

7845: ibhs-24thiaz-bala-betathiome

7846: 2py-42nmeim-ala-betapy

01/283/02 / PB

293

7847: ibhs-24thiaz-bala-betaphethio

7848: phhs-24thioph-bala-betafbph

7849: phhs-me25thioph-ala-psdap

7850: bhs-nme35pyr-gly-betamethi

7851: bim-me25thioph-bala-beta34meoph

7852: bhs-24thioph-gly-betapyr

7853: ibhs-oxadiaz-gly-betaoxaz

7854: bhs-me24thioph-gly-betaph

7855: bhs-53pyrazo-ala-psdap

7856: phhs-oxadiaz-bala-betabdimo

7857: bhs-24thiaz-gly-betadtrif

7858: bim-25oxaz-leu-betadcph

7859: ibhs-ithiadiaz-gly-betapym

7860: bhs-nme35pyr-bala-beta3quin

7861: bhs-ithiadiaz-bala-betabdimo

7862: ibhs-oxadiaz-bala-betahmph

7863: tolhs-25methiaz-gly-betahmo

7864: ibhs-25methiaz-gly-betamethi

7865: ibhs-25thiaz-gly-aspaba

7866: bhs-oxadiaz-bala-betadcphch

7867: ibhs-ithiadiaz-bala-betapych

7868: bhs-24thiaz-gly-betabmph

7869: ibhs-ithiadiaz-gly-csdap

7870: bhs-25oxaz-ala-betameph

7871: bhs-25oxaz-gly-psdapch

7872: bhs-25thiaz-bala-beta35dbph

7873: bim-nme35pyr-bala-betadcph

7874: phhs-oxadiaz-bala-betadcph

7875: bim-24oxaz-leu-zdap

7876: bhs-ithiadiaz-gly-betaphethioa

7877: bhs-24thiaz-gly-betatho3

01/283/02 / PB

294

7878: tolhs-24thiaz-bala-betampy

7879: bhs-24thiaz-gly-betadito

7880: bhs-me24thioph-bala-betaph

7881: 2py-24oxaz-ala-betaainyl

7882: bhs-nme35pyr-bala-betabthioph

7883: phhs-25methiaz-bala-betathio3

7884: bhs-25thiaz-gly-betabph

7885: tolhs-25thiaz-gly-betadcph

7886: ibhs-24thioph-gly-betaimide

7887: ibhs-24thiaz-gly-betadcph

7888: ibhs-ithiadiaz-gly-psdapch

7889: tolhs-me25thiaz-ala-betaph

7890: thazep-42pym-gly-betadcph

7891: bhs-25thiaz-bala-betaol

7892: phhs-ithiadiaz-gly-psdapee

7893: bhs-24thioph-ala-betaipro

7894: bhs-24thioph-gly-betaftrif

7895: bhs-ithiadiaz-bala-betapych

7896: phhs-24thiaz-gly-betaamibe

7897: bhs-nme35pyr-gly-betaphethioa

7898: bim-25methiaz-gly-betaanaphth

7899: bim-thiadiaz-gly-zdap

7900: ibhs-25methiaz-gly-asppha

7901: tolhs-24thiaz-bala-betaphethio

7902: ibhs-24thiaz-bala-psdapch

7903: tolhs-25thiaz-gly-betaanaphth

7904: bhs-25methiaz-bala-betadcphee

7905: tolhs-me24oxaz-bala-betadcph

7906: bhs-25methiaz-bala-psdap

7907: tolhs-nme35pyr-bala-betafph

7908: ibhs-oxadiaz-gly-zdaptb

01/283/02 / PB

295

7909: bhs-oxadiaz-ala-betabpy

7910: bhs-nme35pyr-gly-betathiome

7911: 2py-42oxaz-gly-psdap

7912: bim-me24oxaz-gly-betapy

7913: tolhs-25oxaz-bala-betahb

7914: ibhs-ithiadiaz-gly-betah35dc

7915: phhs-25methiaz-bala-betapym

7916: bhs-ithiadiaz-gly-biisu2be

7917: tolhs-ithiadiaz-bala-betacph

7918: tolhs-24thioph-bala-zdapee

7919: bhs-me25thiaz-leu-psdap

7920: gua-24thiaz-gly-betabnaphth

7921: bhs-oxadiaz-gly-betaipr

7922: bhs-me25thiaz-bala-beta34meoph

7923: bhs-25thiaz-bala-betamethioph

7924: tolhs-24thiaz-bala-betadito

7925: ibhs-ithiadiaz-bala-betacbph

7926: phhs-24thiaz-gly-betafbph

7927: phhs-24thioph-gly-betacph

7928: phhs-25methiaz-bala-betainyl

7929: ibhs-nme35pyr-gly-betabthioph

7930: tolhs-24thiaz-bala-betahph

7931: tolhs-25oxaz-gly-betahcbph

7932: tolhs-me24oxaz-bala-beta34meoph

7933: tolhs-me25oxaz-leu-betaph

7934: bhs-nme35pyr-gly-betafu2

7935: bhs-me25oxaz-gly-beta34meoph

7936: tolhs-25thiaz-bala-betapyee

7937: ibhs-nme35pyr-bala-betaanaphth

7938: bhs-oxadiaz-ala-betathio3

7939: 2py-25fur-ala-betapy

01/283/02 / PB

296

7940: tolhs-25oxaz-bala-csdap

7941: tolhs-nme35pyr-bala-aspibua

7942: 4 pmhs-25methiaz-bala-betameph

7943: bhs-nme35pyr-ala-betabnaphth

7944: phhs-24thiaz-gly-betabmph

7945: tolhs-24thiaz-gly-betaoxaz

7946: ibhs-ithiadiaz-bala-betambiph

7947: impy-25methiaz-bala-betah35dc

7948: tolhs-25oxaz-gly-betaet

7949: phhs-oxadiaz-bala-betampy

7950: phhs-ithiadiaz-gly-betambiph

7951: bhs-nme35pyr-gly-betapytb

7952: phhs-ithiadiaz-bala-betabpy

7953: bim-25thioph-leu-zdap

7954: bhs-24thiaz-ala-betafphe

7955: ibhs-nme35pyr-bala-betafu2

7956: bhs-24thiaz-bala-zdapee

7957: phhs-24thiaz-bala-betacthioph

7958: bim-53pyrazo-leu-zdap

7959: ibhs-24thiaz-bala-zdapee

7960: bim-me25thioph-gly-zdap

7961: ibhs-oxadiaz-bala-betacthioph

7962: tolhs-me25thioph-bala-psdap

7963: phhs-25thiaz-gly-betafu3

7964: ibhs-24thiaz-bala-betabenfu

7965: tolhs-25thiaz-gly-betacbph

7966: bhs-24thiaz-gly-betafbph

7967: bim-35fur-leu-betadcph

7968: bim-25oxaz-bala-betahph

7969: phhs-24thiaz-gly-beta34dcph

7970: ibhs-nme35pyr-gly-beta23meoph

01/283/02 / PB

297

7971: phhs-24thiaz-bala-betamethioph

7972: ibhs-25thiaz-gly-beta3quin

7973: bim-25thioph-leu-psdap

7974: bhs-25thiaz-gly-psdaptb

7975: bhs-ithiadiaz-bala-betambiph

7976: bhs-24thiaz-bala-betabthioph

7977: bhs-24thiaz-gly-beta34meoph

7978: bhs-24thioph-bala-betambiph

7979: bhs-ithiadiaz-ala-psdap

7980: phhs-25thiaz-gly-betapych

7981: bhs-oxadiaz-bala-betaph

7982: 2py-42oxaz-bala-zdap

7983: bhs-oxadiaz-gly-betadcphch

7984: bhs-25thiaz-gly-betabmph

7985: bhs-25methiaz-gly-betafu3

7986: bhs-nme35pyr-gly-betahmofu

7987: ibhs-oxadiaz-bala-psdap

7988: 2py-me24thioph-ala-beta34meoph

7989: 2py-nme35pyr-bala-betadcph

7990: phhs-24thioph-bala-betathio3

7991: 2py-35thioph-ala-betadcph

7992: phhs-24thioph-gly-betahcbph

7993: 2py-35fur-leu-betadcph

7994: ibhs-oxadiaz-bala-betadmph

7995: bhs-nme35pyr-gly-betaph

7996: ibhs-oxadiaz-bala-betapytb

7997: phhs-25thiaz-gly-zdap

7998: impy-25oxaz-gly-betahdbph

7999: bhs-me25oxaz-bala-betadcph

8000: bim-25fur-gly-zdap

8001: bhs-25oxaz-ala-betaipro

01/283/02 / PB

298

8002: bhs-24thioph-nmgly-betahmph

8003: tolhs-nme35pyr-gly-betamethi

8004: bhs-me25thiaz-ala-psdap

8005: gua-24thiaz-gly-betaphethioa

8006: bim-25methiaz-leu-betadcph

8007: ibhs-ithiadiaz-bala-csdap

8008: phhs-25oxaz-gly-aspaba

8009: tolhs-oxadiaz-gly-betathiome

8010: phhs-24thioph-gly-psdapee

8011: phhs-nme35pyr-gly-psdap

8012: bhs-25oxaz-nmgly-betameph

8013: tolhs-oxadiaz-gly-beta23meoph

8014: ibhs-24thiaz-bala-betathioph

8015: tolhs-24thiaz-gly-betaet

8016: bhs-25oxaz-ala-betacthioph

8017: tolhs-oxadiaz-gly-betahmofu

8018: phhs-24thioph-gly-betaet

8019: ibhs-25thiaz-bala-betabph

8020: tolhs-24thioph-bala-betampy

8021: bhs-25oxaz-gly-betahni

8022: bhs-25oxaz-gly-betahmofu

8023: bhs-me25thiaz-ala-betadcph

8024: pbhs-24thioph-bala-beta35dbph

8025: dhim-42pym-ala-psdap

8026: 2py-24thioph-gly-betatbuph

8027: bhs-oxadiaz-ala-betadcph

8028: 2py-35thioph-leu-zdap

8029: phhs-oxadiaz-gly-betaimide

8030: phhs-nme35pyr-gly-betacph

8031: ibhs-nme35pyr-bala-zdap

8032: gua-26py-gly-betadmph

01/283/02 / PB

299

8033: phhs-25thiaz-gly-betaoxope

8034: ibhs-oxadiaz-gly-betaamibe

8035: phhs-24thioph-gly-betapyee

8036: 2py-35thioph-gly-betapy

8037: bhs-35fur-ala-betapy

8038: bhs-24thiaz-nmgly-betamesu

8039: phhs-nme35pyr-gly-betaanaphth

8040: bgua-42pym-gly-betainyl

8041: ibhs-24thiaz-bala-betafphe

8042: bhs-25thiaz-ala-betathio3

8043: tolhs-24thiaz-bala-betacthioph

8044: bhs-25fur-leu-betapy

8045: phhs-24thiaz-gly-betafu3

8046: phhs-24thiaz-gly-betahdcph

8047: tolhs-25thiaz-gly-aspibua

8048: phhs-25oxaz-bala-betapyee

8049: ibhs-oxadiaz-gly-aspaba

8050: phhs-25methiaz-bala-betafbph

8051: bhs-25oxaz-nmgly-betadito

8052: bhs-oxadiaz-bala-betapyee

8053: agua-25oxaz-bala-betameph

8054: bim-me25thioph-bala-betadcph

8055: tolhs-24thiaz-bala-betahb

8056: tolhs-me24thiaz-gly-psdap

8057: bhs-24thiaz-bala-betaphethioa

8058: 2py-25thiaz-leu-zdap

8059: ibhs-oxadiaz-gly-betah35dc

8060: tolhs-24thiaz-gly-beta4bph

8061: bhs-25methiaz-gly-betaipr

8062: tolhs-ithiadiaz-gly-betaibph

8063: dhim-23thioph-gly-betameph

01/283/02 / PB

300

8064: bhs-24thioph-bala-zdaptb

8065: ibhs-25oxaz-gly-betaibph

8066: bhs-oxadiaz-nmgly-betacthioph

8067: bim-me25thioph-gly-betapy

8068: bhs-24thioph-gly-betahbcph

8069: bim-me24oxaz-gly-betaph

8070: impy-25oxaz-bala-betahmo

8071: ibhs-25methiaz-gly-beta23meoph

8072: 2py-ithiadiaz-bala-psdap

8073: phhs-24thiaz-gly-betatos

8074: bim-me24oxaz-leu-betaph

8075: 2py-26py-gly-psdap

8076: bhs-24thiaz-ala-betathio3

8077: bhs-25thiaz-bala-betatrif

8078: bim-24thiaz-gly-aspibua

8079: phhs-oxadiaz-bala-betathiome

8080: tolhs-24thioph-gly-betaibph

8081: phhs-24thiaz-bala-betaphethio

8082: tolhs-ithiadiaz-bala-betaph

8083: bhs-24thiaz-bala-betathiome

8084: bhs-me25thioph-gly-zdap

8085: phhs-nme35pyr-gly-betathiome

8086: tolhs-ithiadiaz-gly-zdapee

8087: phhs-25oxaz-bala-betaamibe

8088: bim-24oxaz-bala-psdap

8089: phhs-25oxaz-bala-aspbzla

8090: bim-42oxaz-gly-zdap

8092: ibhs-25thiaz-bala-betatos

8092: ibhs-oxadiaz-bala-aspaba

8093: phhs-nme35pyr-gly-betadcph

8094: gua-24thiaz-gly-beta3quin

01/283/02 / PB

301

8095: 2py-25oxaz-gly-betathiobe

8096: tolhs-25methiaz-bala-betabnaphth

8097: bhs-25oxaz-ala-betacph

8098: bhs-nme35pyr-bala-betahcbph

8099: bim-me24thioph-ala-betaph

8100: ibhs-25methiaz-bala-ibsdap

8101: bhs-25methiaz-leu-zdap

8102: bhs-25thiaz-ala-betadhbfu

8103: bim-42oxaz-gly-psdap

8104: bhs-25thiaz-gly-betabiph

8105: gua-25thioph-gly-betaipr

8106: phhs-24thioph-gly-betapych

8107: bhs-25oxaz-gly-beta23meoph

8108: tolhs-24thioph-bala-asppha

8109: bhs-24thiaz-gly-betaipro

8110: tolhs-ithiadiaz-bala-betahdcph

8111: bim-24thiaz-ala-zdap

8112: tolhs-25thiaz-bala-beta34meoph

8113: bhs-ithiadiaz-gly-betaipro

8114: tolhs-25thiaz-gly-betapych

8115: tolhs-24thioph-bala-aspibua

8116: bhs-nme35pyr-gly-betafbph

8117: dhim-52thiaz-ala-betadcph

8118: 2py-35fur-ala-betadcph

8119: phhs-25thiaz-bala-zdap

8120: 2 pmhs-25thiaz-gly-betahbcph

8121: bhs-25thiaz-bala-betahph

8122: bhs-oxadiaz-bala-betathiobe

8123: bhs-25methiaz-ala-betathioph

8124: tolhs-25oxaz-gly-aspaba

8125: 2py-24thiaz-gly-beta35dbph

01/283/02 / PB

302

8126: ibhs-ithiadiaz-gly-betahc

8127: bhs-oxadiaz-bala-betabdimo

8128: phhs-25oxaz-bala-betaphethio

8129: bhs-25oxaz-ala-beta13bendi

8130: phhs-ithiadiaz-bala-beta23meoph

8131: bhs-25methiaz-gly-betafph

8132: tolhs-24thiaz-gly-betaol

8133: tolhs-oxadiaz-gly-betaipro

8134: tolhs-25methiaz-gly-aspbzla

8135: ibhs-oxadiaz-gly-betaanaphth

8136: tolhs-oxadiaz-bala-betaoxope

8137: bhs-25methiaz-nmgly-betacthioph

8138: 2 pmhs-25thiaz-gly-betaph

8139: bhs-25oxaz-gly-betadcphch

8140: bim-25oxaz-bala-betabmph

8141: bhs-nme35pyr-gly-betafphe

8142: bhs-ithiadiaz-bala-betatos

8143: phhs-24thiaz-gly-betamethi

8144: thpym-24oxaz-gly-zdap

8145: tolhs-me25thiaz-bala-beta34meoph

8146: tolhs-nme35pyr-bala-betaimide

8147: bhs-nme35pyr-ala-betainyl

8148: bhs-25oxaz-gly-betatbuph

8149: 2py-42pym-ala-betadcph

8150: tolhs-24thioph-gly-betafph

8151: bim-me25oxaz-bala-betapy

8152: bim-25methiaz-bala-aspbzla

8153: 2py-me25thiaz-ala-zdap

8154: tolhs-25thiaz-gly-psdaptb

8155: 2py-52thiaz-ala-betadcph

8156: bhs-25oxaz-bala-betah35dc

01/283/02 / PB

303

8157: gua-24oxaz-gly-betaipro

8158: tolhs-me25thioph-ala-psdap

8159: gua-24thiaz-gly-betamethi

8160: bhs-nme35pyr-leu-betadcph

8161: bim-oxadiaz-gly-betapy

8162: bhs-35fur-ala-psdap

8163: bhs-25methiaz-gly-betapy

8164: ibhs-24thiaz-bala-beta13bendi

8165: tolhs-24thiaz-bala-beta3quin

8166: bhs-ithiadiaz-bala-betatrif

8167: bhs-ithiadiaz-gly-betahmph

8168: tolhs-ithiadiaz-gly-betaheph

8169: tolhs-24thioph-gly-betampy

8170: tolhs-25oxaz-gly-betathiome

8171: ibhs-nme35pyr-gly-betahdcph

8172: ibhs-oxadiaz-bala-betabediox

8173: phhs-25methiaz-bala-betadhbfu

8174: bhs-25methiaz-gly-betabnaphth

8175: bhs-ithiadiaz-bala-betacph

8176: bhs-24thioph-bala-betadmph

8177: tolhs-nme35pyr-bala-betafu3

8178: phhs-25methiaz-gly-betahni

8179: ibhs-25methiaz-bala-betaphethioa

8180: tolhs-nme35pyr-bala-betamethioph 8181: tolhs-nithiadiaz-bala-betaphethio

8182: tolhs-25methiaz-gly-betaipro

8183: ibhs-24thiaz-gly-betaanaphth

8184: bhs-nme35pyr-bala-betabediox

8185: 2 pmhs-42nmeim-bala-betapym

8186: ibhs-25oxaz-gly-betaipro

8187: phhs-24thioph-gly-psdap

01/283/02 / PB

304

8188: bhs-25oxaz-nmgly-betathio3 8189: bhs-24thioph-bala-betadtrif 8190: tolhs-ithiadiaz-bala-betamethi 8191: tolhs-25methiaz-bala-betabenfu 8192: ibhs-24thioph-bala-betadiof 8: 19h -gly-betahb

8194: tolhs-me24thiaz-gly-zdap

8195: phhs-oxadiaz-gly-betathioph

8196: bhs-25thiaz-gly-betafphe

8197: ibhs-24thioph-bala-betaipr

8198: gua-25thioph-gly-betapyr

8199: phhs-nme35pyr-gly-betameph 8200: ibhs-25oxaz-gly-zdap 8201: ibhs-25methiaz-gly-zdap

8202: bhs-24thiaz-ala-betainyl

8203: bhs-nme35pyr-bala-betathiome 8204: bhs-24thiaz-bala-betathiobe 8205: tolhs-24thiaz-bala-betapym 8206: tolhs-25methiaz-gly-betathioph 8207: tolhs-ithiadiaz-bala-betapym 8205: tolhs-24thiaz-bala-betapym 8203 -bala-betaimide 8209: tolhs-ithiadiaz-bala-betaipro 8210: bhs-25thiaz-bala-beta13bendi 8211: 2 pmhs-24thioph-gly-betabpy 8212: ibhs-ithiadiaz-bala-betadcph 8213: bhs-24thiaz-glyth-bis-glyph-8thiazh : bhs-25oxaz-bala-betahmno 8215: 2py-me24oxaz-leu-betaph 8216: tolhs-25methiaz-gly-betahph 8217: phhs-25oxaz-gly-betapyr

8218: bhs-25oxaz-nmgly-betafphe

01/283/02 / PB

305

8219: bim-25thiaz-gly-betameph

8220: bhs-oxadiaz-bala-aspbzla

8221: bim-25oxaz-gly-betahb

8222: phhs-me25thiaz-ala-zdap

8223: tolhs-me24oxaz-bala-betapy

8224: gua-24thiaz-gly-betahbcph

8225: bim-24oxaz-ala-betainyl

8226: 2 pmhs-25oxaz-gly-betathio3

8227: bhs-25oxaz-bala-betadcphtb

8228: 2py-me24oxaz-gly-betaph

8229: bhs-24thiaz-nmgly-beta34dcph

8230: ibhs-nme35pyr-bala-beta13bendi

8231: bhs-me24thiaz-gly-psdap

8232: ibhs-nme35pyr-bala-betadtrif

8233: tolhs-nme35pyr-bala-betaoxope

8234: 2py-25fur-leu-betapy

8235: tolhs-nme35pyr-bala-betahc

8236: 2py-me24thiaz-ala-psdap

8237: bim-me24thiaz-ala-betapy

8238: tolhs-25thiaz-gly-betabthioph

8239: 2py-25thioph-bala-psdap

8240: ibhs-25thiaz-gly-betahdcph

8241: bim-26py-gly-psdap

8242: 2py-35fur-gly-betapy

8243: phhs-25methiaz-bala-betabph

8244: phhs-25thiaz-bala-betahbcph

8245: ibhs-24thioph-gly-betadcphtb

8246: 2py-me25thiaz-leu-betaph

8247: ibhs-25thiaz-gly-betaipr

8248: ibhs-24thioph-gly-betacbph

8249: ibhs-25methiaz-bala-betaamibe

01/283/02 / PB

306

8250: phhs-25methiaz-gly-betapyee 8251: bhs-24thioph-bala-betahdbph 8252: bhs-24thiaz-gly-aspbzla

8253: phhs-25methiaz-bala-betadcphch

8254: bhs-nme35pyr-gly-betabph

8255: bim-42nmeim-bala-betambiph

8256: bhs-25thiaz-gly-betaet

8257: ibhs-nme35pyr-gly-betaamibe

8258: ibhs-oxadiaz-bala-betahmo

8259: tolhs-oxadiaz-bala-asppha

8260: ibhs-nme35pyr-bala-betacph 8261: phhs-ithiadiaz-bala-betabthioph 8262: bhs-25thiaz-gly-betafph

8263: hyd-25thioph-gly-zdap

8264: phhs-24thiaz-bala-betahmph

8265: ibhs-nme35pyr-gly-betabnaphth

8266: tolhs-me25oxaz-bala-betaph

8267: impy-24thioph-gly-betabediox

8268: tolhs-me25oxaz-leu-betadcph

8269: tolhs-oxadiaz-gly-betadmoph

8270: bhs-26py-gly-betaph

8271: bhs-24thioph-gly-asppha

8272: bhs-25oxaz-gly-betacph

8273: bhs-24thiaz-bala-betapbiph

8274: ibhs-nme35pyr-gly-betaph

8275: phhs-25thiaz-bala-beta3quin

8276: dhim-42pym-gly-betameph

8277: 2py-25methiaz-bala-beta34dcph

8278: tolhs-25methiaz-gly-betaphethioa

8279: bhs-24thioph-bala-betathio3

8280: bim-24thioph-bala-betampy

01/283/02 / PB

307

8281: phhs-24thiaz-gly-betabph

8282: bim-24thiaz-bala-betaimide

8283: tolhs-me25thiaz-bala-betaph

8284: phhs-24thioph-gly-zdapee

8285: phhs-24thioph-bala-betadcph

8286: tolhs-ithiadiaz-gly-betampy

8287: bhs-25methiaz-gly-csdap

8288: bhs-42nmeim-ala-psdap

8289: phhs-oxadiaz-gly-betabmph

8290: tolhs-oxadiaz-gly-betaheph

8291: bhs-oxadiaz-ala-betapy

8292: ibhs-oxadiaz-bala-betahni

8293: ibhs-24thioph-bala-betaph

8294: phhs-25oxaz-bala-psdap

8295: tolhs-me25thioph-leu-betadcph

8296: phhs-25thiaz-bala-betahni

8297: phhs-nme35pyr-bala-beta34meoph

8298: phhs-nme35pyr-bala-betafphe

8299: 2py-25thiaz-bala-betaoxope

8300: tolhs-ithiadiaz-bala-psdapee

8301: tolhs-25methiaz-gly-betapbiph

8302: ibhs-ithiadiaz-bala-betabmph

8303: bim-24thiaz-gly-aspbzla

8304: phhs-oxadiaz-bala-betabthioph

8305: bhs-25fur-leu-psdap

8306: bhs-nme35pyr-gly-betadcphch

8307: 2py-oxadiaz-leu-zdap

8308: tolhs-24thioph-bala-betadmph

8309: 2 pmhs-25methiaz-phe-zdap

8310: phhs-25methiaz-bala-betapyee

8311: bhs-25methiaz-ala-betameph

ίι, ΐί: ίΐίι \ ιί ^ ΜΜ11Μ

01/283/02 / PB

308

8312: phhs-me24oxaz-leu-psdap

8313: 2 pmhs-42nmeim-bala-betampy

8314: bhs-ithiadiaz-gly-betaoxaz

8315: tolhs-me25thiaz-leu-betadcph

8316: tolbs-24thioph-bala-betahmofu

8317: bim-24thiaz-gly-betapbiph

8318: tolhs-me24thiaz-ala-beta34meoph

8319: bhs-24thioph-nmgly-betafphe

8320: ibhs-24thioph-bala-aspaba

8321: bhs-ithiadiaz-nmgly-betadmph

8322: tolhs-25thiaz-gly-betaimide

8323: bhs-24thiaz-ala-beta34meoph

8324: tolhs-25thiaz-bala-betafu3

8325: phhs-25methiaz-gly-betapy

8326: tolhs-25methiaz-gly-betadcphee

8327: tolhs-25methiaz-gly-betafu2

8328: phhs-24thiaz-bala-betahni

8329: bhs-25oxaz-gly-beta34dcph

8330: ibhs-25methiaz-bala-betacph

8331: phhs-24thioph-gly-aspaba

8332: bhs-53pyrazo-ala-zdap

8333: bhs-ithiadiaz-bala-psdaptb

8334: ibhs-oxadiaz-bala-psdapee

8335: bhs-nme35pyr-gly-ibsdap

8336: bhs-52thiaz-ala-betameph

8337: bhs-nme35pyr-mugly-betadito

8338: phhs-24thioph-bala-betadhbfu

8339: phhs-25oxaz-bala-betaanaphth

8340: bhs-nme35pyr-gly-betacthioph

8341: bhs-25methiaz-gly-betadmoph

8342: tolhs-24thioph-gly-betabph

01/283/02 / PB

309

8343: phhs-24thiaz-gly-zdap

8344: bhs-25oxaz-gly-betadbph

8345: tolhs-ithiadiaz-bala-betameph

8346: phhs-25oxaz-gly-betapy

8347: bhs-25methiaz-bala-betadhbfu

8348: bim-25oxaz-leu-zdap

8349: bhs-ithiadiaz-gly-csdap

8350: tolhs-24thiaz-gly-zdaptb

8351: ibhs-nme35pyr-bala-betaph

8352: ibhs-25thiaz-bala-betapyr

8353: ibhs-24thiaz-gly-betahmo

8354: ur-25thiaz-gly-betadcph

8355: ibhs-25methiaz-bala-betabnaphth

8356: tolhs-24thiaz-gly-asppha

8357: bhs-24thiaz-nmgly-betaoxaz

8358: ibhs-25methiaz-gly-betacph

8359: bhs-25oxaz-ala-psdap

8360: bim-ithiadiaz-bala-asppha

8361: dhim-26py-gly-betambiph

8362: phhs-25oxaz-gly-beta34meoph

8363: 2py-ithiadiaz-ala-zdap

8364: 2 pmhs-42nmeim-bala-betadhbfu

8365: phhs-nme35pyr-gly-betabpy

8366: ibhs-ithiadiaz-gly-betadhbfu

8367: bhs-25methiaz-bala-betamethi

8368: tolhs-oxadiaz-bala-betafluo

8369: phhs-25oxaz-gly-betapyee

8370: phhs-25thiaz-bala-betapyee

8371: ibhs-oxadiaz-gly-betacph

8372: bim-53pyrazo-bala-betapy

8373: phhs-25oxaz-bala-betabph

01/283/02 / PB

8374: bhs-24thioph-bala-betaphethio

8375: 2py-me25oxaz-ala-betaph

8376: tolhs-nme35pyr-gly-betatos

8377: ibhs-nme35pyr-bala-betaoxope

8378: tolhs-25thiaz-bala-betabpy

8379: gua-25tbiaz-gly-betabnaphth

8380: bhs-24thioph-nmgly-beta34meoph

8381: impy-42nmeim-bala-betaph

8382: ibhs-24thioph-gly-betapy

8383: tolhs-25thiaz-gly-betacthioph

8384: tolhs-25thiaz-gly-betabnaphth

8385: bhs-24thioph-gly-betafphe

8386: tolhs-oxadiaz-bala-betadcph

8387: bim-25thiaz-gly-betaanaphth

8388: 2py-ithiadiaz-bala-betadcph

8389: dhim-53pyrazo-gly-betameph

8390: ibhs-25thiaz-gly-beta34dcph

8391: tolhs-25thiaz-bala-beta3quin

8392: bhs-24thioph-bala-betadito

8393: gua-24oxaz-gly-betabph

8394: 2py-triaz-ala-betadcph

8395: bhs-25oxaz-bala-psdapch

8396: bhs-nme35pyr-nmgly-betameph

8397: phbs-25oxaz-bala-betah35dc

8398: impy-24thiaz-bala-betamesu

8399: 2 pmhs-25oxaz-bala-betaheph

8400: bhs-25oxaz-bala-beta23meoph

8401: impy-25oxaz-bala-betahdcph

8402: 2py-me25oxaz-gly-zdap

8403: phhs-24thiaz-bala-betacph

8404: phhs-oxadiaz-bala-betacph

310

01/283/02 / PB

8405: tolhs-nme35pyr-bala-betapych 8406: tolhs-25oxaz-bala-betamethioph 8407: bhs-ithiadiaz-gly-beta34dcph 8408: tolhs-me25thioph-leu-zdap 8409: ibhs-25thiaz-bala-phiaz-bethasm-25thiaz-beta-phiaz-10-phiazh -bala-zdapee 8411: bhs-oxadiaz-gly-betatbuph 8412: bhs-42nmeim-bala-betatbuph 8413: 2py-42nmeim-bala-betadmph 8414: phhs-25oxaz-bala-betaoxaz 8415: 2py-24oxaz-gly-betameph : tolhs-ithiadiaz-bala-betabenf 8417: 2py-42nmeim-phg-betadcph 8418: ibhs-24thiaz-gly-betahc 8419: phhs-25thiaz-gly-betabediox 8420: tolhs-24thioph-bala-betatrif 8421: bhs-25 bala-psdap 8422: ibhs-25thiaz-bala-betaibph 8423: tolhs-nme35pyr-bala-psdapch 8424: tolhs-24thioph-gly-betaph 8425: bhs-ithiadiaz-gly-betabnaphth 8426: bim-25methiaz-al7: zdap-ala: zdapch ibhs-ithiadiaz-gly-betafluo 8428: bhs-25thiaz-bala-betafu2 8429: phhs-nme35pyr-gly-csdap 8430: thpym-24oxaz-gly-betahdcph 8431: bim-25thioph-gly-betadcph 8432: bhs-25 -betadmoph 8433: bhs-24thioph-gly-psdaptb 8434: bim-me24oxaz-ala-psdap 8435: gua-26py-gly-betadcph

311

01/283/02 / PB

312

8436: bhs-ithiadiaz-bala-betapytb 8437: phhs-25methiaz-gly-betadito 8438: impy-24thiaz-bala-betah35dc 8439: ibhs-24thiaz-bala-betapyr 8440: bhs-25thiaz-gly-betameph 8441: tolhs-25az -gly-betabenfu 8442: 2py-25thiaz-leu-betadcph 8443: bhs-24thiaz-gly-betacbph 8444: bhs-25thiaz-bala-busu2be 8445: bhs-oxadiaz-gly-betaimide 8446: ibhs-oxad iaz-g ly- betaftrif 8447: bhs-ithiadiaz-bala-betah35dc 8448: bhs-25methiaz-bala-betaftrif 8449: phhs-24thiaz-gly-betahmph 8450: tolhs-me25thiaz-gly-betadcph 8451: phhs-me24thiaz-bala-psdap 8ps1 me24thioph-ala-betadcph 8453: bhs-24thioph-bala-betadmoph 8454: ibhs-25thiaz-gly-betapym 8455: phhs-24thiaz-gly-betaoxaz 8456: 2py-25thiaz-bala-asppha 8457: bhs-me25thioph-bet25mph 8458: phhs-24thiaz-gly-betabpy 8459: bim-25oxaz-gly-betapy 8460: phhs-24thioph-gly-betapytb 8461: ibhs-ithiadiaz-gly-betatrif 8462: bhs-24thiaz-bala-csdap 8463: phhs-ithith -bala-zdapee 8464: 2py-25fur-ala-psdap 8465: tolhs-me25oxaz-bala-betapy 8466: ibhs-nme35pyr-bala-betadit o

01/283/02 / PB

313

8467: 2 pmhs-24thioph-gly-betahb

8468: thpym-24thiaz-gly-betahcbph

8469: ibhs-ithiadiaz-gly-betahcbph

8470: ibhs-oxadiaz-gly-betapyr

8471: ibhs-25oxaz-gly-betafph

8472: phhs-24thioph-gly-psdaptb

8473: bhs-25oxaz-gly-betafu2

8474: ibhs-25methiaz-gly-betadcphtb

8475: dhim-24thiaz-gly-psdap

8476: bhs-ithiadiaz-bala-betafu2

8477: tolhs-25methiaz-bala-betameph

8478: phhs-25thiaz-bala-betafu2

8479: gua-24oxaz-gly-busu2be

8480: phhs-nme35pyr-bala-betahc

8481: phhs-24thiaz-gly-betahc

8482: phhs-25oxaz-gly-asppha

8483: phhs-nme35pyr-gly-betafu2

8484: ibhs-24thioph-bala-betabmph

8485: phhs-ithiadiaz-gly-betaol

8486: bhs-25methiaz-nmgly-betadhbfu 8487: tolhs-24thioph-gly-betaanaphth 8488: tolhs-24thiaz-bala-betameph

8489: phhs-25thiaz-bala-betamesu

8490: tolhs-25methiaz-gly-asppha 8491: ibhs-ithiadiaz-bala-betabpy

8492: bhs-25thiaz-gly-betahb

8493: phhs-25oxaz-bala-betambiph

8494: bim-35fur-ala-betadcph

8495: bhs-oxadiaz-bala-betacbph

8496: bhs-nme35pyr-bala-betadcphtb

8497: bhs-26py-gly-betadcph

01/283/02 / PB

314

8498: ibhs-25thiaz-bala-betafu3

8499: phhs-24thiaz-gly-suabu

8500: bim-24oxaz-ala-betadcph

8501: bhs-oxadiaz-nmgly-betafphe

8502: bhs-24thioph-bala-betampy

8503: bim-25methiaz-bala-zdap

8504: tolhs-oxadiaz-gly-betaibph

8505: 2py-me24thiaz-gly-psdap

8506: thpym-42nmeim-bala-betapy

8507: bhs-25oxaz-bala-betahni

8508: 2py-oxadiaz-leu-betadcph

8509: ibhs-oxadiaz-bala-zdapee

8510: gua-42nmeim-bala-psdap

8511: gua-25thioph-gly-beta35dbph

8512: bhs-25oxaz-gly-betafph

8513: ibhs-nme35pyr-gly-betahni

8514: ibhs-ithiadiaz-bala-betafu2

8515: phhs-25oxaz-bala-betadmoph

8516: bim-triaz-leu-betapy

8517: 2py-24oxaz-gly-betadcph

8518: tolhs-25thiaz-gly-betapy

8519: tolhs-ithiadiaz-gly-csdap

8520: tolhs-25thiaz-bala-betathio3

8521: 2py-25oxaz-gly-betabediox

8522: ibhs-ithiadiaz-bala-betathio3

8523: tolhs-ithiadiaz-bala-beta3quin

8524: agua-25thiaz-gly-psdap

8525: ibhs-ithiadiaz-gly-betameph

8526: pbhs-me25oxaz-ala-zdap

8527: 2 pmhs-24thiaz-bala-zdap

8528: bim-oxadiaz-bala-aspbzla

01/283/02 / PB

8529: bhs-25thiaz-ala-betathioph

8530: bhs-nme35pyr-bala-beta4bph

8531: phhs-me25thiaz-bala-beta34meoph

8532: bhs-24thioph-gly-betapych

8533: gua-24oxaz-gly-betadito

8534: tolhs-me25thioph-gly-betaph

8535: impy-25methiaz-gly-beta34meoph

8536: phhs-ithiadiaz-gly-betacbph

8537: ibhs-nme35pyr-bala-betaftrif

8538: 2py-25thioph-leu-psdap

8539: phhs-25oxaz-bala-betatos

8540: dhim-24thioph-gly-betapy

8541: tolhs-24thioph-bala-betabdimo

8542: bhs-42nmeim-bala-betathio3

8543: bhs-42nmeim-ala-zdap

8544: phhs-nme35pyr-bala-betabpy

8545: ibhs-nme35pyr-gly-betacbph

8546: bhs-25methiaz-bala-betadcphtb

8547: tolhs-me24oxaz-gly-beta34meoph

8548: tolhs-25oxaz-bala-betaftrif

8549: 3 pmhs-24thiaz-gly-betapy

8550: bhs-24thioph-bala-betaamibe

8551: bim-24thioph-bala-zdap

8552: ibhs-24thiaz-gly-beta3quin

8553: tolhs-nme35pyr-gly-betafluo

8554: gua-26py-gly-betatrif

8555: phhs-me24thiaz-leu-betadcph

8556: 2 pmhs-42nmeim-gly-betabdimo

8557: bim-52thiaz-gly-betapy

8558: phhs-25thiaz-gly-csdap

8559: phhs-25oxaz-gly-betahcbph

315

01/283/02 / PB

316

8560: phhs-oxadiaz-bala-betambiph

8561: ibhs-25oxaz-bala-ibsdap

8562: tolhs-24thioph-gly-betaipro

8563: bhs-24thiaz-bala-betaanaphth

8564: tolhs-25methiaz-gly-betatos

8565: tolhs-ithiadiaz-bala-betatbuph

8566: bhs-oxadiaz-gly-suabu

8567: 2 pmhs-42nmeim-gly-betafbph

8568: 2py-me24thioph-bala-zdap

8569: phhs-nme35pyr-bala-suabu

8570: phhs-24thiaz-bala-betahcbph

8571: phhs-25thiaz-bala-betapych

8572: ibhs-24thioph-gly-psdapch

8573: ibhs-24thiaz-gly-betaphethioa

8574: tolhs-25methiaz-bala-betadtrif

8575: ibhs-ithiadiaz-bala-zdap

8576: bhs-24thioph-bala-betacph

8577: bhs-nme35pyr-gly-betathioph

8578: nmhs-25thioph-gly-betameph

8579: bhs-ithiadiaz-bala-betaheph

8580: ibhs-oxadiaz-gly-betamethioph 8581: phhs-24thioph-gly-betathiobe

8582: bhs-oxadiaz-gly-psdapch

8583: bim-26py-ala-betameph

8584: tolhs-25oxaz-gly-betaamibe

8585: phhs-24thioph-bala-beta13bendi

8586: phhs-25methiaz-bala-betadbph

8587: 2 pmhs-25oxaz-bala-betahni

8588: ibhs-24thioph-gly-aspibua

8589: dhim-25thioph-gly-psdap

8590: phhs-25oxaz-gly-betaipro

Shea

01/283/02 / PB 317

8591: bhs-25methiaz-gly-beta34meoph

8592: bhs-me25thioph-leu-betaph

8593: 2py-25oxaz-bala-betah35dc

8594: 2 pmhs-24thioph-gly-betadtrif

8595: phhs-nme35pyr-bala-psdapch

8596: tolhs-25methiaz-gly-betadito

8597: ibhs-25oxaz-gly-beta34meoph

8598: bhs-25oxaz-bala-betaoxope

8599: phhs-nme35pyr-gly-betadcphch

8600: bhs-24thioph-gly-betathioph

8601: phhs-25thiaz-gly-betaphethioa

8602: phhs-25thiaz-gly-betambiph

8603: tolhs-ithiadiaz-gly-betafph

8604: bhs-nme35pyr-bala-betaph

8605: ibhs-25oxaz-gly-betapytb

8606: bim-24thiaz-gly-aspaba

8607: gua-26py-gly-busu2be

8608: bhs-25oxaz-ala-beta34meoph

8609: phhs-nme35pyr-bala-betapyr

8610: phias-ithiadiaz-gly-beta35dbph

8611: tolhs-me24oxaz-leu-betadcph

8612: bhs-24thiaz-gly-betahph

8613: phhs-25oxaz-gly-csdap

8614: tolhs-25thiaz-gly-betatos

8615: tolhs-25methiaz-gly-beta23meoph

8616: tolhs-24thiaz-bala-asppha

8617: ibhs-ithiadiaz-gly-psdaptb

8618: bhs-me24thiaz-bala-betapy

8619: phhs-25methiaz-bala-betahc

8620: ibhs-24thioph-bala-betamesu

8621: bhs-25oxaz-gly-csdap

01/283/02 / PB

318

8622: ibhs-nme35pyr-gly-psdapee 8623: ibhs-25methiaz-gly-betafu3 8624: 2py-me24thiaz-ala-betadcph 8625: bhs-25thiaz-bala-betabdimo 8626: phhs-nme35pyr-bala-betapych 8243 -ala-betapy 8628: bhs-25thiaz-gly-betaanaphth 8629: phhs-ithiadiaz-gly-betadcph 8630: bhs-25oxaz-gly-betapyr 8631: phhs-nme35pyr-gly-betaphethio 8632: phhs-25oxaz-gly-betameph 8633 : ibhs-25oxaz-gly-betabenfu 8634: phhs-24thiaz-bala-betapyr 8635: tolhs-ithiadiaz-gly-betadbph 8636: ibhs-24thiaz-gly-betaoxaz 8637: bhs-25thiaz-gly-betampy 8638: phhs-24thiaz- bala-betadtrif 8639: bhs-24thioph-gly-busu2be 8640: tolhs-ithiadiaz-gly-beta3quin 8641: tolhs-ithiadiaz-bala-betapyee 8642: gua-25thiaz-bala-betadcph 8643: tolhs-oxadiaz-gly-bet-8644 ibhs-24thiaz-gly-betahbcph 8645: ibhs-25methiaz-gly-betadbph 8646: 2py-24thioph-gly-aspaba 8647: ibhs-25thiaz-gly-betahni 8648: ibhs-oxadiaz-bala-betacph 8649: bhs-25thiaz -betacbph 8650: 2py-42oxaz-leu-psdap 8651: bhs-nme35pyr-gly-betahcbph 8652: tolhs-25thiaz-bala- betambiph

01/283/02 / PB

319

8653: phhs-oxadiaz-gly-betapych

8654: bhs-25methiaz-bala-betadcph

8655: tolhs-ithiadiaz-gly-betatos

8656: bhs-me25oxaz-gly-betadcph

8657: phhs-oxadiaz-gly-zdapch

8658: tolhs-oxadiaz-bala-betafbph

8659: bim-me25thioph-gly-psdap

8660: 2py-24thioph-bala-suabu

8661: 2 pmhs-24thioph-phe-zdap

8662: bim-24oxaz-leu-betapy

8663: bhs-25oxaz-bala-betapbiph

8664: ibhs-25methiaz-gly-betafph

8665: phhs-25thiaz-gly-betathioph

8666: tolhs-24thioph-gly-betatbuph

8667: gua-26py-gly-betaibph

8668: ibhs-24thiaz-bala-betabmph

8669: phhs-ithiadiaz-gly-psdaptb

8670: phhs-nme35pyr-gly-beta23meoph

8671: bhs-25thiaz-bala-betampy

8672: ibhs-25thiaz-bala-psdapee

8673: 2 pmhs-25thiaz-bala-betahph

8674: 2py-53pyrazo-bala-psdap

8675: bhs-oxadiaz-gly-betabnaphth

8676: 2py-42oxaz-bala-psdap

8677: bim-24thioph-phg-zdap

8678: tolhs-25thiaz-gly-betahmo

8679: bhs-24thiaz-nmgly-betadmoph

8680: phhs-nme35pyr-gly-betaet

8681: phhs-24thioph-bala-betapyee

8682: phhs-ithiadiaz-gly-beta34meoph

8683: bhs-42py-ala-zdap

01/283/02 / PB

320

8684: bhs-24oxaz-ala-psdap

8685: impy-42nmeim-gly-beta4bph

8686: 2py-25thiaz-ala-betapy

8687: bim-me24oxaz-gly-psdap

8688: bhs-24thioph-gly-betabdimo

8689: tolhs-nme35pyr-bala-ibsdap

8690: gua-25thiaz-gly-betathiobe

8691: phhs-24thiaz-bala-beta35dbph

8692: 3 pmhs-25oxaz-gly-betadcph

8693: phhs-24thioph-gly-betaheph

8694: dhim-26py-leu-zdap

8695: phhs-24thioph-gly-betathiome

8696: bhs-35thioph-ala-zdap

8697: bim-42oxaz-gly-betadcph

8698: phhs-25methiaz-gly-betafph

8699: bhs-ithiadiaz-bala-betaphethio

8700: phhs-nme35pyr-bala-betamethioph

8701: phhs-25thiaz-gly-betabph

8702: ibhs-24thioph-gly-betafluo

8703: bhs-25methiaz-bala-zdapee

8704: phhs-ithiadiaz-gly-betahmofu

8705: bhs-24thioph-gly-betathio3

8706: bhs-25thioph-bala-zdap

8707: phhs-24thioph-bala-betapytb

8708: phhs-24thiaz-bala-betatos

8709: phhs-nme35pyr-bala-betahb

8710: bhs-24thiaz-gly-betaomebendi

8711: phhs-nme35pyr-bala-beta13bendi 8712: tolhs-25methiaz-bala-betafu3

8713: bhs-thiadiaz-bala-betadcph

8714: phhs-25thiaz-bala-betathiobe

01/283/02 / PB

321

8715: tolhs-me25thiaz-bala-betapy

8716: phhs-oxadiaz-gly-betadhbfu

8717: tolhs-oxadiaz-bala-betah35dc

8718: bim-24thioph-bala-betacph

8719: bim-me25oxaz-gly-zdap

8720: tolhs-me25thiaz-ala-beta34meoph

8721: ibhs-24thiaz-gly-zdapch

8722: bhs-ithiadiaz-gly-betahdbph

8723: bhs-24thioph-gly-betaamibe

8724: bhs-25oxaz-gly-betabdimo

8725: 2py-me25oxaz-gly-psdap

8726: gua-25thiaz-gly-betabediox

8727: phhs-24thioph-bala-suabu

8728: bhs-24thioph-ala-betadmoph

8729: 2py-nme35pyr-leu-zdap

8730: tolhs-ithiadiaz-bala-busu2be

8731: tolhs-nme35pyr-gly-betahph

8732: 2py-25oxaz-gly-psdap

8733: ibhs-25methiaz-gly-betafluo

8734: bhs-25thiaz-bala-betabediox

8735: impy-25thiaz-gly-betabthioph

8736: bhs-24thiaz-ala-betahph

8737: tolhs-me25thioph-bala-beta34meoph

8738: gua-26py-gly-betathioph

8739: ibhs-24thioph-bala-betabnaphth

8740: tolhs-24thiaz-gly-betahmo

8741: tolhs-ithiadiaz-gly-beta23meoph

8742: phhs-25methiaz-bala-betafu3

8743: phhs-24thioph-bala-betaomebendi

8744: bim-24thiaz-bala-betaipro

8745: tolhs-me24oxaz-ala-betapy ^: yy1) and |, gydg1yj »n |> 1

01/283/02 / PB 322

8746: 2 pmhs-25thiaz-gly-betafph

8747: ibhs-oxadiaz-bala-betabenfu

8748: bim-25methiaz-gly-betadbph

8749: phhs-25methiaz-bala-betabediox

8750: tolhs-ithiadiaz-gly-betahdcph

8751: bhs-25thiaz-leu-betadcph

8752: phhs-oxadiaz-bala-zdaptb

8753: phhs-ithiadiaz-bala-betadtrif

8754: bhs-42oxaz-leu-psdap

8755: phhs-oxadiaz-gly-betaanaphth

8756: ibhs-25thiaz-gly-betathio3

8757: bhs-24thiaz-bala-psdapee

8758: bhs-25oxaz-bala-betaimide

8759: phhs-25thiaz-bala-betadcphtb

8760: 2py-triaz-bala-psdap

8761: tolhs-25methiaz-gly-betahcbph

8762: bhs-ithiadiaz-bala-betameph

8763: bim-24thioph-ala-betapy

8764: bhs-25oxaz-gly-betaphethioa

8765: bim-24thiaz-gly-betahmph

8766: phhs-25methiaz-gly-betadcphch

8767: ibhs-24thioph-bala-betafluo

8768: tolhs-24thiaz-gly-betapym

8769: bhs-24thioph-gly-betahcbph

8770: ibhs-nme35pyr-gly-betahc

8771: 2py-me25thioph-ala-betapy

8772: 2py-53pyrazo-bala-zdap

8773: ibhs-oxadiaz-bala-betafu2

8774: ibhs-25oxaz-gly-zdapee

8775: phhs-25thiaz-gly-betapytb

8776: ibhs-25oxaz-bala-beta34dcph

01/283/02 / PB

323

8777: tolhs-25oxaz-bala-betaphethio

8778: bhs-oxadiaz-bala-psdapee

8779: tolhs-oxadiaz-gly-betahdbph

8780: 2py-25methiaz-gly-betapy

8781: ibhs-24thiaz-gly-betahcbph

8782: bhs-25methiaz-gly-betafbph

8783: phhs-24thiaz-gly-betahb

8784: 2 pmhs-24thioph-bala-zdap

8785: phhs-24thiaz-bala-betabdimo

8786: tolhs-nme35pyr-bala-betaoxaz

8787: hts-25methiaz-gly-betapy

8788: phhs-me25thioph-bala-beta34meoph

8789: bhs-24thiaz-gly-betadhbfu

8790: gua-25thioph-gly-betafu3

8791: 2 pmhs-24thiaz-bala-beta13bendi

8792: bhs-oxadiaz-gly-beta4bph

8793: ibhs-24thiaz-gly-beta13bendi

8794: ibhs-25methiaz-gly-betaoxaz

8795: tolhs-oxadiaz-gly-beta13bendi

8796: ibhs-24thiaz-bala-busu2be

8797: bim-me24thiaz-ala-beta34meoph

8798: phhs-ithiadiaz-bala-betacthioph

8799: bim-24thioph-gly-psdap

8800: 2 pmhs-25oxaz-hphe-betadcph

8801: bhs-me24thioph-bala-betapy

8802: ibhs-24thiaz-gly-psdaptb

8803: bhs-24thiaz-gly-betacthioph

8804: phhs-oxadiaz-bala-betathioph

8805: bim-24oxaz-gly-betameph

8806: phhs-nme35pyr-bala-betahdcph

8807: bim-24thiaz-bala-aspibua

01/283/02 / PB

324

8808: 2py-nme35pyr-ala-zdap 8809: dhim-24oxaz-ala-psdap 8810: tolhs-25oxaz-gly-beta35dbph 8811: tolhs-25methiaz-bala-zdaptb 8812: bhs-oxadiaz-gly-betafu2 8813: bhs-oxad -bala-beta34dcph 8814: tolhs-25thiaz-gly-betadtrif 8815: tolhs-24thiaz-gly-betaomebendi 8816: tolhs-me24thioph-gly-betapy 8817: bhs-25methiaz-gly-aspbzla 8818: tolhs-24thioph-bala-19an-betaanap : ibhs-25methiaz-bala-betameph 8820: 2py-24im-leu-betapy 8821: bhs-25thiaz-gly-beta35dbph 8822: bim-42nmeim-gly-betadcph 8823: tolhs-me24thiaz-bala-betaph 8824: bhs-me24thiaz- leu-betaph 8825: bhs-25methiaz-gly-psdapch 8826: phhs-me25oxaz-leu-betadcph 8827: 2py-me25oxaz-ala-zdap 8828: phhs-24thiaz-bala-psdapch 8829: phhs-24thiaz-bala-psdaptb 8830: phhs-24thioph-gly-betacthioph 8831: ibhs-ithiadiaz-gly-betabmph 8832: bim-24oxaz-ala-betameph 8833: ibhs-25methiaz-bala-betahph 8834: tolhs-25oxaz-gly-betadcph 8835: iphyr-n35 -betahmo 8836: ibhs-ithiadiaz-bala-psdapee 8837: ibhs-25oxaz-bala-betabp 8838: bhs-oxadiaz-gly-beta3 quin

01/283/02 / PB

325

8839: phhs-25oxaz-gly-betaamibe

8840: tolhs-25thiaz-gly-aspbzla

8841: phhs-nme35pyr-gly-beta35dbph

8842: 2py-25methiaz-ala-zdap

8843: tolhs-24thiaz-bala-betapyr

8844: bhs-24thiaz-bala-betabenfu

8845: ibhs-nme35pyr-gly-betafu3

8846: ibhs-ithiadiaz-gly-betadtrif

8847: tolhs-24thioph-gly-zdapch

8848: phhs-me25thioph-bala-betapy

8849: 2py-25thiaz-ala-zdap

8850: phhs-ithiadiaz-bala-betaipro

8851: bim-me25oxaz-ala-betaph

8852: ibhs-24thiaz-bala-betadcphee

8853: phhs-25methiaz-bala-betambiph

8854: tolhs-ithiadiaz-bala-betafph

8855: phhs-25thiaz-bala-betadito

8856: 4 pmhs-26py-gly-psdap

8857: bhs-25thiaz-nmgly-betahph

8858: tolhs-24thioph-bala-betabpy

8859: phhs-24thiaz-gly-betatbuph

8860: phhs-25thiaz-gly-betabenfu

8861: bhs-25oxaz-gly-betaftrif

8862: phhs-25oxaz-gly-betaimide

8863: phhs-25oxaz-bala-betacph

8864: tolhs-25thiaz-bala-betabnaphth

8865: bhs-25thioph-gly-betadcph

8866: bhs-24oxaz-gly-zdap

8867: bhs-25thioph-gly-betameph

8868: phhs-nme35pyr-bala-betainyl

8869: phhs-me25thiaz-bala-psdap

01/283/02 / PB

326

8870: tolhs-25oxaz-bala-betathio3

8871: impy-25thiaz-bala-betafu3

8872: bim-25methiaz-phg-zdap

8873: phhs-24thiaz-bala-betadcph

8874: tolhs-24thiaz-gly-zdapch

8875: phhs-25methiaz-gly-zdaptb

8876: bhs-24thiaz-nmgly-beta23meoph

8877: tolhs-me25oxaz-leu-zdap

8878: gua-25thioph-gly-betahni

8879: tolhs-25thiaz-bala-betahph

8880: ibhs-25oxaz-gly-betaph

8881: bhs-ithiadiaz-bala-betadcph

8882: tolhs-25methiaz-gly-betabdimo

8883: phhs-nme35pyr-gly-betapbiph

8884: bhs-25thiaz-gly-suabu

8885: bim-me25oxaz-ala-betapy

8886: phhs-25oxaz-gly-betathiome

8887: impy-24thiaz-gly-betahmofu

8888: tolhs-nme35pyr-gly-betadcphtb

8889: gua-26py-gly-betaphethioa

8890: 2py-oxadiaz-bala-betadcph

8891: tolhs-nme35pyr-gly-betadcphee

8892: tolhs-nme35pyr-bala-betaipr

8893: tolhs-me25thioph-leu-betaph

8894: 2py-24im-bala-betadcph

8895: ibhs-24thiaz-gly-betatos

8896: ibhs-25thiaz-gly-betaipro

8897: gua-25thioph-gly-betadbph

8898: tolhs-ithiadiaz-bala-betabmph

8899: tolhs-25methiaz-gly-betampy

8900: phhs-nme35pyr-gly-betafbph

..... I

01/283/02 / PB

327

8901: 2py-25fur-ala-zdap

8902: ibhs-24thioph-bala-betahmofu

8903: tolhs-24thiaz-bala-betaftrif

8904: bhs-25methiaz-gly-betaheph

8905: phhs-25methiaz-gly-aspibua

8906: bim-24thiaz-bala-betahcbph

8907: 2py-25thioph-ala-psdap

8908: bim-24thioph-leu-betadcph

8909: bhs-nme35pyr-gly-beta34dcph

8910: bhs-ithiadiaz-bala-betapy

8911: ibhs-nme35pyr-bala-betadmoph

8912: 2py-me24oxaz-leu-zdap

8913: tolhs-ithiadiaz-gly-betapyee

8914: bhs-25oxaz-bala-betabnaphth

8915: phhs-nme35pyr-bala-betaomebendi

8916: bhs-24thioph-nmgly-betaoxaz

8917: bhs-nme35pyr-gly-betabdimo

8918: ibhs-nme35pyr-gly-betadcph

8919: bim-25methiaz-bala-betatos

8920: phhs-nme35pyr-bala-beta35dbph

8921: bhs-42nmeim-bala-beta3quin

8922: phhs-oxadiaz-bala-betahdbph

8923: ibhs-24thioph-bala-betabenfu

8924: phhs-ithiadiaz-bala-busu2be

8925: bhs-24thiaz-bala-beta34dcph

8926: sabhs-24oxaz-gly-zdap

8927: phhs-25oxaz-gly-betahdbph

8928: bhs-24thiaz-gly-betapyr

8929: ibhs-ithiadiaz-bala-betabthioph

8930: bhs-nme35pyr-nmgly-betadmoph

8931: ibhs-ithiadiaz-gly-betabph

328

01/283/02 / PB

8932: tolhs-25methiaz-bala-betapbiph

8933: tolhs-me24oxaz-ala-betaph

8934: phhs-25thiaz-bala-betadcphee

8935: gua-25thioph-gly-betabenfu

8936: ibhs-nme35pyr-gly-beta34dcph

8937: bhs-me24thioph-ala-beta34meoph

8938: bhs-25thiaz-nmgly-beta34meoph

8939: phhs-ithiadiaz-gly-betadmoph

8940: phhs-nme35pyr-bala-zdaptb

8941: bhs-ithiadiaz-gly-betathioph

8942: gua-24thiaz-gly-betabmph

8943: 2py-24thioph-gly-betapy

8944: bhs-24thiaz-bala-psdap

8945: bhs-24thiaz-gly-betaibph

8946: phhs-oxadiaz-gly-betapbiph

8947: bim-triaz-bala-betadcph

8948: hs-42pym-gly-psdap

8949: tolhs-ithiadiaz-bala-suabu

8950: tolhs-24thioph-bala-betacbph

8951: phhs-me25oxaz-leu-psdap

8952: bhs-oxadiaz-gly-beta35dbph

8953: phhs-25oxaz-gly-betahph

8954: tolhs-me25oxaz-leu-beta34meoph

8955: bhs-oxadiaz-gly-aspibua

8956: tolhs-25methiaz-bala-betabediox

8957: phhs-oxadiaz-gly-psdapee

8958: phhs-nme35pyr-bala-betaipro

8959: bhs-nme35pyr-bala-betamph

8960: phhs-25oxaz-gly-betabediox

8961: bhs-25thiaz-bala-betapych

8962: tolhs-25methiaz-gly-betadtrif

01/283/02 / PB

329

8963: bhs-24thioph-leu-psdap

8964: 2py-24im-bala-psdap

8965: bim-42nmeim-gly-betaftrif

8966: bhs-24thioph-bala-betameph

8967: phhs-ithiadiaz-gly-betaphethioa

8968: 2 pmhs-24thioph-bala-betabmph

8969: phhs-24thiaz-bala-betathiobe

8970: tolhs-me25thioph-ala-betadcph

8971: bhs-25methiaz-gly-zdapch

8972: ibhs-25methiaz-bala-betadcphee

8973: phhs-25oxaz-gly-aspibua

8974: tolhs-25thiaz-bala-busu2be

8975: phhs-24thioph-bala-betaphethio

8976: ibhs-25methiaz-gly-betahph

8977: tolhs-24thioph-bala-betaol

8978: tolhs-25oxaz-gly-betapyee

8979: ibhs-ithiadiaz-bala-beta35dbph

8980: bhs-25methiaz-bala-betadcphch 8981: phhs-nme35pyr-bala-betabenfu

8982: phhs-nme35pyr-gly-betadhbfu

8983: bhs-ithiadiaz-ala-betabpy

8984: ibhs-24thioph-gly-betahph

8985: 2py-me25thiaz-ala-betapy

8986: bim-53pyrazo-ala-psdap

8987: 2py-nme35pyr-bala-zdap

8988: 2py-nme35pyr-gly-aspaba

8989: bhs-oxadiaz-bala-betahdbph

8990: bhs-oxadiaz-gly-betaol

8991: ibhs-25oxaz-bala-betahb

8992: tolhs-25oxaz-gly-ibsdap

8993: tolhs-nme35pyr-gly-asppha

01/283/02 / PB

330

8994: phhs-25oxaz-gly-betafph

8995: bhs-25oxaz-ala-betadmoph

8996: bim-ithiadiaz-bala-psdap

8997: bhs-me25oxaz-leu-zdap

8998: ibhs-25thiaz-bala-busu2be

8999: bim-me24thioph-leu-psdap

9000: bhs-me25thioph-ala-zdap

9001: phhs-oxadiaz-bala-betahmo

9002: bhs-ithiadiaz-bala-betafluo

9003: bhs-25methiaz-bala-betafph

9004: bhs-53pyrazo-gly-zdap

9005: bhs-ithiadiaz-gly-betah35dc

9006: tolhs-25methiaz-gly-csdap

9007: phhs-me25thiaz-leu-zdap

9008: ibhs-nme35pyr-gly-betaet

9009: bhs-oxadiaz-ala-beta3quin

9010: phhs-24thiaz-bala-betaol

9011: bhs-25methiaz-gly-betatbuph

9012: bhs-25thiaz-gly-psdap

9013: tolhs-me24thioph-gly-psdap

9014: tolhs-nme35pyr-gly-betadbph

9015: bhs-24thioph-gly-betabediox

9016: tolhs-25methiaz-gly-aspaba

9017: 2 pmhs-25methiaz-gly-betadtrif

9018: ibhs-25oxaz-bala-betahdcph

9019: bim-oxadiaz-gly-asppha

9020: phhs-nme35pyr-bala-beta4bph

9021: bhs-25oxaz-ala-betahmph

9022: tolhs-25oxaz-bala-betahni

9023: phhs-me24oxaz-ala-psdap

9024: bhs-42nmeim-gly-zdap

01/283/02 / PB

331

9025: phhs-25methiaz-gly-betahmo

9026: bhs-24thiaz-nmgly-betapy

9027: ibhs-24thiaz-bala-zdaptb

9028: bim-35thioph-bala-betadcph

9029: ibhs-ithiadiaz-gly-betaipr

9030: bhs-25thiaz-bala-aspibua

9031: phhs-25oxaz-gly-betadcphch

9032: 2py-me25thiaz-gly-psdap

9033: ibhs-25thiaz-bala-beta3quin

9034: bhs-25thiaz-leu-zdap

9035: dhthi-24thioph-bala-betadcph

9036: ibhs-oxadiaz-gly-psdapch

9037: ibhs-25oxaz-bala-zdaptb

9038: tolhs-25oxaz-gly-betaimide

9039: bhs-ithiadiaz-bala-betahc

9040: bhs-oxadiaz-gly-betampy

9041: bhs-me24thiaz-bala-psdap

9042: tolhs-24thiaz-gly-psdap

9043: phhs-25thiaz-bala-betapym

9044: bim-ithiadiaz-gly-betapy

9045: bhs-oxadiaz-bala-betainyl

9046: ibhs-25oxaz-bala-betadmph

9047: ibhs-24thiaz-bala-psdaptb

9048: bhs-24thiaz-bala-betadcph

9049: bhs-24thiaz-gly-beta34dcph

9050: bhs-ithiadiaz-gly-zdap

9051: agua-24thiaz-gly-psdap

9052: 2py-24thioph-leu-zdap

9053: phhs-24thioph-gly-betatbuph

9054: ibhs-25oxaz-gly-betadhbfu

9055: bhs-ithiadiaz-gly-betahni

01/283/02 / PB

332

9056: 2py-24thioph-bala-betabnaphth

9057: gua-26py-gly-betahni

9058: phhs-24thioph-bala-beta34meoph

9059: bhs-25methiaz-gly-betadbph

9060: bhs-triaz-leu-betapy

9061: bhs-ithiadiaz-gly-betaimide

9062: ibhs-24thiaz-gly-betaamibe

9063: gua-24thiaz-gly-betahph

9064: phhs-25methiaz-gly-zdapch

9065: phhs-oxadiaz-gly-aspaba

9066: bhs-25methiaz-leu-betadcph

9067: 2 pmhs-25methiaz-bala-betahph

9068: phhs-24thioph-bala-beta3quin

9069: dhim-52thiaz-gly-betadcph

9070: tolhs-25oxaz-gly-aspibua

9071: 2py-nme35pyr-bala-aspbzla

9072: bhs-24thiaz-bala-betahmph

9073: tolhs-24thioph-bala-betahmo

9074: impy-25oxaz-gly-betadhbfu

9075: phhs-25thiaz-bala-betapytb

9076: bhs-25methiaz-gly-asppha

9077: ibhs-24thiaz-bala-betathio3

9078: impy-25oxaz-ser-zdap

9079: bhs-ithiadiaz-gly-betacph

9080: bhs-24thioph-gly-betadtrif

9081: tolhs-me24oxaz-gly-zdap

9082: phhs-25methiaz-bala-betaipro

9083: bhs-24oxaz-bala-betapy

9084: bhs-25methiaz-gly-betacthioph

9085: bhs-25methiaz-ala-betadmph

9086: bhs-24thiaz-bala-betathio3

01/283/02 / PB

333

9087: bhs-nme35pyr-gly-betaet

9088: phhs-nme35pyr-bala-betaftrif

9089: bhs-24thiaz-gly-betadcphch

9090: tolhs-oxadiaz-bala-beta34dcph

9091: tolhs-24thioph-gly-betaoxope

9092: hyd-25methiaz-bala-betameph

9093: bhs-25oxaz-bala-betapych

9094: phhs-me24thiaz-gly-betapy

9095: bhs-24thioph-bala-betahmofu

9096: ibhs-25thiaz-gly-beta4bph

9097: tolhs-25thiaz-gly-betadhbfu

9098: tolhs-25oxaz-gly-betaoxaz

9099: 2py-me24oxaz-gly-betapy

9100: ibhs-25oxaz-bala-betapym

9101: bhs-24im-ala-psdap

9102: ibhs-oxadiaz-bala-betathioph

9103: bim-42nmeim-bala-psdap

9104: bhs-me25oxaz-bala-betaph

9105: 2py-me24thiaz-bala-betadcph

9106: ibhs-24thiaz-gly-betafiuo

9107: bhs-oxadiaz-gly-betamethioph

9108: tolhs-24thiaz-bala-betathiome

9109: 2py-42pym-gly-psdap

9110: bhs-24thioph-bala-betapy

9111: bim-25oxaz-gly-zdap

9112: 2py-24pym-gly-betapy

9113: bim-35fur-gly-zdap

9114: phhs-25methiaz-bala-betafphe

9115: tolhs-25methiaz-bala-betapytb

9116: bim-25thioph-ala-zdap

9117: tolhs-oxadiaz-bala-betahni

01/283/02 / PB

334

9118: 2py-triaz-leu-zdap

9119: phhs-ithiadiaz-gly-beta23meoph

9120: tolhs-oxadiaz-bala-zdaptb

9121: bhs-triaz-ala-betapy

9122: bim-35thioph-leu-betapy

9123: bhs-25thioph-leu-zdap

9124: tolhs-25oxaz-bala-betadcph

9125: 2py-oxadiaz-gly-aspibua

9126: phhs-oxadiaz-bala-betatos

9127: phhs-ithiadiaz-gly-betaftrif

9128: bhs-25thiaz-bala-betaphethioa

9129: phhs-ithiadiaz-gly-psdap

9130: bim-26py-gly-zdap

9131: phhs-oxadiaz-bala-betafphe

9132: gua-42pym-gly-betahdbph

9133: dimethpym-26py-gly-betadcph

9134: phhs-24thiaz-gly-asppha

9135: tolhs-nme35pyr-gly-betaoxope

9136: bim-me24thiaz-bala-betapy

9137: phhs-oxadiaz-gly-betaamibe

9138: phhs-nme35pyr-gly-betamethioph

9139: phhs-25oxaz-bala-betafu3

9140: tolhs-25methiaz-bala-betaamibe

9141: ibhs-ithiadiaz-bala-betampy

9142: tolhs-oxadiaz-gly-betabnaphth

9143: bhs-25thiaz-gly-zdapee

9144: phhs-24thiaz-gly-betafph

9145: bhs-25methiaz-ala-betadito

9146: phhs-24thioph-bala-betadmoph

9147: tolhs-25oxaz-gly-betahdcph

9148: tolhs-nme35pyr-gly-betaph

01/283/02 / PB

335

9149: ibhs-ithiadiaz-gly-betapych

9150: tolhs-25methiaz-gly-betadcph

9151: phhs-25oxaz-bala-betathiome

9152: phhs-ithiadiaz-bala-betabenfu

9153: bhs-25oxaz-gly-betadcphtb

9154: ibhs-25oxaz-gly-betathiobe

9155: bhs-25oxaz-gly-betahdbph

9156: 2py-me24thiaz-leu-zdap

9157: phhs-25oxaz-gly-betahmo

9158: thazep-25thiaz-gly-betapy

9159: bhs-42nmeim-hphe-zdap

9160: bim-42oxaz-bala-zdap

9161: phhs-25oxaz-gly-aspbzla

9162: ibhs-25thiaz-gly-betafu3

9163: ibhs-24thiaz-bala-asppha

9164: ibhs-ithiadiaz-bala-betadcphtb

9165: tolhs-me24oxaz-gly-betapy

9166: tolhs-24thiaz-gly-betadcphee

9167: tolhs-25thiaz-gly-betathioph

9168: bim-24thioph-bala-betahcbph

9169: ibhs-25methiaz-bala-betambiph

9170: phhs-nme35pyr-gly-betampy

9171: ibhs-25thiaz-bala-betahdcph

9172: tolhs-25oxaz-bala-asppha

9173: bhs-24thiaz-leu-betadcph

9174: bhs-me24oxaz-ala-psdap

9175: phhs-nme35pyr-gly-betabthioph

9176: gua-26py-gly-betafu3

9177: 2 pmhs-24thioph-bala-betathioph

9178: ibhs-25methiaz-bala-asppha

9179: phhs-25oxaz-gly-betapych

01/283/02 / PB

336

9180: bhs-24thiaz-phe-betapy

9181: tolhs-25thiaz-bala-betaheph

9182: ibhs-24thiaz-gly-betapyr

9183: bhs-24thiaz-bala-betafluo

9184: bim-25thioph-gly-betainyl

9185: bhs-me24thiaz-bala-beta34meoph

9186: bhs-25oxaz-nmgly-betaanaphth

9187: bhs-24thiaz-bala-betahcbph

9188: bhs-nme35pyr-bala-betah35dc

9189: ur-24thiaz-gly-betadcph

9190: phhs-25thiaz-gly-zdapch

9191: tolhs-25thiaz-gly-betahmofu

9192: bhs-25oxaz-nmgly-beta34dcph

9193: tolhs-oxadiaz-gly-beta4bph

9194: tolhs-25methiaz-gly-betaol

9195: phhs-24thioph-bala-betapyr

9196: bim-nme35pyr-gly-asppha

9197: 2py-24thioph-bala-betaoxope

9198: bhs-oxadiaz-bala-betacph

9199: ibhs-oxadiaz-bala-betacbph

9200: 2py-me24thiaz-gly-zdap

9201: ibhs-24thiaz-bala-betahbcph

9202: bhs-24thioph-bala-suabu

9203: tolhs-24thioph-gly-psdaptb

9204: phhs-oxadiaz-gly-betahmph

9205: phhs-25methiaz-bala-betaheph

9206: ibhs-25methiaz-gly-betadcphee

9207: bhs-25thiaz-gly-betadcphee

9208: bhs-25thiaz-gly-beta13bendi

9209: bhs-24thioph-gly-beta13bendi

9210: bhs-25thiaz-gly-betamethioph

01/283/02 / PB

337

9211: 2py-me24oxaz-bala-zdap

9212: 2py-25oxaz-gly-betahmofu

9213: phhs-25thiaz-bala-betabenfu

9214: bhs-25oxaz-ala-betadmph

9215: ibhs-24thiaz-gly-betabenfu

9216: phhs-oxadiaz-gly-betatbuph

9217: 2py-me25oxaz-bala-betapy

9218: tolhs-nme35pyr-gly-betadito

9219: bhs-25thiaz-nmgly-betathio3

9220: bhs-nme35pyr-nmgly-betahph

9221: bhs-25oxaz-ala-betathio3

9222: phhs-24thiaz-gly-betambiph

9223: bhs-24thiaz-bala-betaamibe

9224: bhs-24thioph-bala-betabnaphth

9225: tolhs-oxadiaz-gly-zdapch

9226: ibhs-24thiaz-gly-betaftrif

9227: phhs-ithiadiaz-gly-betadmph

9228: ibhs-25thiaz-bala-betacthioph

9229: bhs-53pyrazo-gly-betapy

9230: phhs-25thiaz-gly-betaoxaz

9231: ibhs-nme35pyr-bala-psdap

9232: bhs-nme35pyr-bala-beta13bendi

9233: ibhs-25oxaz-bala-betabthioph

9234: bhs-25oxaz-bala-betadcphee

9235: tolhs-25methiaz-bala-betamesu

9236: tolhs-25methiaz-gly-betabmph

9237: bhs-24oxaz-gly-betainyl

9238: pahs-25methiaz-bala-betameph

9239: bhs-25nmethiaz-ala-betacph

9240: ibhs-25thiaz-gly-betathiobe

9241: bhs-42nmeim-gly-betadcph

01/283/02 / PB

338

9242: tolhs-oxadiaz-gly-betahni

9243: ibhs-24thiaz-bala-betatos

9244: dimethpym-24thiaz-gly-betameph

9245: tolhs-25thiaz-gly-betapyee

9246: hs-24thiaz-gly-betapy

9247: phhs-24thiaz-gly-betacthioph

9248: bim-35thioph-bala-psdap

9249: tolhs-25methiaz-gly-betaamibe

9250: bim-25oxaz-gly-betadcph

9251: 2py-46pym-gly-betapy

9252: bhs-oxadiaz-ala-betaipro

9253: dhim-52thiaz-gly-betameph

9254: 2py-ithiadiaz-gly-betadcph

9255: bhs-25methiaz-nmgly-betahmph

9256: bim-24thioph-gly-betadmph

9257: bhs-25thiaz-bala-aspbzla

9258: ibhs-25thiaz-bala-betafphe

9259: ibhs-25methiaz-gly-betaanaphth

9260: tolhs-24thioph-bala-betahcbph

9261: phhs-25oxaz-bala-psdaptb

9262: ibhs-24thioph-gly-betahdbph

9263: ibhs-25oxaz-bala-betainyl

9264: tolhs-25oxaz-gly-betahni

9265: bhs-oxadiaz-bala-betamethioph

9266: 2py-me24oxaz-ala-psdap

9267: tolhs-me24oxaz-ala-beta34meoph

9268: bhs-25thiaz-bala-betapyr

9269: tolhs-me24oxaz-leu-psdap

9270: tolhs-24thioph-gly-betapytb

9271: bhs-oxadiaz-bala-betapych

9272: ibhs-25methiaz-bala-betaphethio

01/283/02 / PB

339

9273: 2py-thiadiaz-ala-psdap

9274: bhs-oxadiaz-nmgly-beta13bendi

9275: tolhs-nme35pyr-gly-betainyl

9276: ibhs-25thiaz-bala-betabthioph

9277: bim-triaz-gly-zdap

9278: tolhs-24thioph-gly-betacthioph

9279: ibhs-nme35pyr-gly-betadhbfu

9280: bhs-25thiaz-bala-betahmofu

9281: ibhs-25oxaz-gly-betaomebendi

9282: tolhs-me25thioph-gly-zdap

9283: phhs-ithiadiaz-bala-betaheph

9284: ibhs-25thiaz-bala-zdapee

9285: tolhs-nme35pyr-bala-betabph

9286: phhs-me24oxaz-bala-betapy

9287: 2py-me25thioph-gly-psdap

9288: bim-24thiaz-gly-betaomebendi

9289: 2py-42pym-gly-betadcph

9290: bim-24im-bala-betadcph

9291: ibhs-25methiaz-gly-betafu2

9292: bhs-24thioph-ala-ibsdap

9293: phhs-ithiadiaz-gly-betapbiph

9294: 2 pmhs-25thiaz-gly-betathiome

9295: phhs-25thiaz-bala-betaoxope

9296: phhs-me25oxaz-gly-beta34meoph

9297: tolhs-25methiaz-bala-betahni

9298: ibhs-nme35pyr-gly-betaomebendi

9299: bim-42pym-gly-psdap

9300: tolhs-oxadiaz-gly-betaet

9301: tolhs-nme35pyr-gly-betafph

9302: bim-25thiaz-leu-zdap

9303: bhs-ithiadiaz-bala-betampy

01/283/02 / PB

340

9304: phhs-25methiaz-bala-betatrif

9305: phhs-25thiaz-gly-betaph

9306: sabhs-25thioph-gly-betapy

9307: phhs-25oxaz-gly-betahmofu

9308: imhs-42nmeim-gly-betameph

9309: bhs-ithiadiaz-bala-betahdcph

9310: 2py-35thioph-ala-psdap

9311: bim-42nmeim-gly-betamethi

9312: bhs-25oxaz-ala-beta23meoph

9313: tolhs-25thiaz-gly-betadcphch

9314: phhs-oxadiaz-gly-betabpy

9315: bhs-24oxaz-gly-betadcph

9316: bhs-25methiaz-ala-betaipro

9317: tolhs-24thiaz-gly-psdapch

9318: bim-me24thiaz-bala-betadcph

9319: tolhs-nme35pyr-bala-psdap

9320: phhs-25thiaz-bala-betafbph

9321: bim-25fur-ala-betapy

9322: ibhs-ithiadiaz-gly-betathiome

9323: bhs-oxadiaz-bala-betabediox

9324: dhim-25thiaz-ala-betainyl

9325: bim-25thiaz-gly-asppha

9326: bhs-nme35pyr-bala-betahmofu

9327: bhs-ithiadiaz-bala-betathioph

9328: bhs-nme35pyr-bala-betacbph

9329: bhs-25methiaz-bala-aspbzla

9330: 2py-me25thioph-gly-betadcph 9331: tolhs-ithiadiaz-bala-betatrif

9332: 2 pmhs-25thiaz-bala-beta4bph

9333: ibhs-nme35pyr-gly-betameph

9334: tolhs-25thiaz-bala-betatrif

01/283/02 / PB

341

9335: bim-me25thioph-ala-betaph

9336: tolhs-24thiaz-gly-beta3quin

9337: bhs-26py-ala-betameph

9338: bhs-42oxaz-bala-psdap

9339: 2py-triaz-bala-betadcph

9340: bhs-25methiaz-ala-betabpy

9341: tolhs-24thioph-bala-zdap

9342: bhs-me25oxaz-leu-psdap

9343: phhs-25methiaz-bala-betabdimo

9344: bhs-nme35pyr-bala-suabu

9345: phhs-25thiaz-bala-betahc

9346: phhs-24thiaz-gly-betaanaphth

9347: 2py-52thiaz-gly-betameph

9348: bhs-nme35pyr-gly-asppha

9349: dimethpym-42nmeim-gly-betadcph

9350: bhs-ithiadiaz-bala-betapbiph

9351: bhs-oxadiaz-gly-betaph

9352: ibhs-ithiadiaz-gly-betafu2

9353: phhs-25oxaz-bala-betahbcph

9354: bhs-24thiaz-met-betapy

9355: bhs-ithiadiaz-bala-betatbuph

9356: bhs-ithiadiaz-ala-betathioph

9357: 2py-25oxaz-gly-beta34meoph

9358: 2py-25thiaz-ala-betadcph

9359: 2py-me25thioph-gly-betapy

9360: phhs-ithiadiaz-bala-beta3quin

9361: phhs-nme35pyr-gly-betaomebendi

9362: bhs-oxadiaz-bala-psdapch

9363: ibhs-25oxaz-gly-betaipr

9364: ibhs-24thiaz-gly-betacthioph

9365: phhs-me25thiaz-ala-betaph

01/283/02 / PB

342

9366: bhs-24oxaz-leu-zdap

9367: phhs-nme35pyr-gly-betah35dc

9368: phhs-me25thioph-ala-beta34meoph

9369: dhpyrr-25thiaz-gly-zdap

9370: phhs-25thiaz-bala-betaomebendi

9371: bhs-52thiaz-gly-betadcph

9372: phhs-ithiadiaz-gly-betadbph

9373: 2py-25fur-ala-betadcph

9374: gua-24thiazme-gly-betapy

9375: tolhs-24thiaz-gly-beta35dbph

9376: tolhs-25oxaz-gly-betadbph

9377: phhs-nme35pyr-gly-zdap

9378: bhs-me24oxaz-gly-betaph

9379: gua-25thiaz-gly-betaimide

9380: tolhs-25oxaz-bala-betaomebendi

9381: tolhs-24thiaz-gly-betaipro

9382: bim-triaz-ala-betapy

9383: bhs-24thioph-gly-zdapee

9384: ibhs-nme35pyr-gly-betafluo

9385: ibhs-25oxaz-bala-betaomebendi

9386: phhs-25methiaz-bala-betapytb

9387: bhs-25methiaz-bala-betapyr

9388: tolhs-25oxaz-bala-betacph

9389: phhs-oxadiaz-bala-aspbzla

9390: tolhs-25methiaz-bala-betaftrif

9391: tolhs-ithiadiaz-bala-betabthioph

9392: bhs-24thiaz-gly-betamesu

9393: bhs-24thiaz-ala-betadhbfu

9394: tolhs-24thioph-bala-betadcphch

9395: ibhs-nme35pyr-bala-zdapch

9396: bhs-oxadiaz-gly-betahph

01/283/02 / PB

343

9397: bhs-25oxaz-gly-betaol

9398: tolhs-24thioph-gly-zdap

9399: bhs-oxadiaz-ala-betadmoph

9400: phhs-oxadiaz-bala-betapyr 9401: bhs-nme35pyr-bala-aspbzla

9402: 2py-25oxaz-bala-betamethi 9403: bhs-oxadiaz-gly-betahcbph

9404: tolhs-ithiadiaz-bala-aspaba

9405: ibhs-oxadiaz-bala-betambiph

9406: bim-thiadiaz-ala-zdap

9407: phhs-24thioph-bala-betatbuph

9408: bhs-25thiaz-gly-betaipr

9409: tolhs-25methiaz-bala-betacthioph 9410: phhs-24thiaz-bala-betadmoph 9411: gua-42pym-gly-beta13bendi 9412: tolhs-25methiaz-gly-betahmph

9413: ibhs-25oxaz-gly-betameph

9414: bhs-24thiaz-bala-psdaptb 9415: bhs-nme35pyr-gly-betadcphtb

9416: bhs-24thiaz-bala-betadmph

9417: phhs-ithiadiaz-gly-busu2be

9418: bim-24thiaz-ala-betainyl

9419: phhs-25oxaz-bala-betahmph

9420: phhs-25thiaz-gly-psdapee 9421: ibhs-nme35pyr-bala-betahmph 9422: gua-24oxaz-gly-betaphethioa 9423: 2 pmhs-42nmeim-gly-betadmoph 9424: ibhs-24thioph-bala-betadhph 9425: ibhs-24thioph-bala-betadbph 9425: -bala-betabmph 9426: bim-24oxaz-ala-betapy

9427: tolhs-25methiaz-gly-betafbph

01/283/02 / PB

344

9428: bhs-25oxaz-gly-betapy

9429: bhs-nme35pyr-bala-betafph

9430: 2py-24thiaz-bala-betahni

9431: phhs-ithiadiaz-bala-betafu2

9432: impy-42nmeim-phe-betadcph

9433: tolhs-24thioph-gly-betadcph

9434: bhs-ithiadiaz-gly-betafbph

9435: bhs-nme35pyr-gly-betameph

9436: bhs-25oxaz-gly-betabpy

9437: ibhs-25oxaz-gly-psdapee

9438: bim-25fur-bala-betadcph

9439: bhs-25thiaz-gly-aspbzla

9440: 2py-oxadiaz-ala-psdap

9441: bim-24thiaz-leu-zdap

9442: tolhs-oxadiaz-gly-betampy

9443: 2 pmhs-25thioph-ala-betameph

9444: bhs-25thioph-ala-zdap

9445: bhs-24thioph-gly-betaomebendi

9446: phhs-25oxaz-gly-betaibph

9447: bhs-42nmeim-leu-zdap

9448: bhs-oxadiaz-leu-betadcph

9449: bhs-ithiadiaz-ala-betahmph

9450: bhs-25methiaz-gly-betadcphch

9451: tolhs-nme35pyr-gly-betaphethioa

9452: gua-26py-gly-betatos

9453: bhs-24thiaz-bala-betadtrif

9454: ibhs-ithiadiaz-bala-betaibph

9455: dhim-26py-ala-betaph

9456: bim-35thioph-ala-psdap

9457: phhs-25thiaz-bala-betaamibe

9458: 2py-26py-ala-psdap

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345

9459: 2py-25thiaz-gly-beta3quin

9460: bhs-25methiaz-bala-betapym

9461: tolhs-24thiaz-bala-betapbiph

9462: tolhs-ithiadiaz-gly-betamesu

9463: phhs-24thioph-bala-betathiome

9464: ibhs-25oxaz-gly-betaphethio

9465: tolhs-oxadiaz-gly-betadmph

9466: ibhs-24thiaz-bala-betadbph

9467: bim-nme35pyr-bala-aspaba

9468: 2py-35fur-ala-zdap

9469: phhs-ithiadiaz-bala-betahcbph

9470: ibhs-25methiaz-gly-betapbiph

9471: tolhs-25methiaz-bala-betadcphch

9472: ibhs-25methiaz-gly-betatbuph

9473: bim-42oxaz-bala-betapy

9474: phhs-24thiaz-gly-zdapch

9475: tolhs-24thiaz-bala-betatos

9476: bhs-42oxaz-bala-betapy

9477: bim-35fur-bala-betadcph

9478: 2py-me24thioph-ala-betapy

9479: tolhs-25oxaz-gly-betamesu

9480: tolhs-nme35pyr-gly-betabnaphth

9481: ibhs-oxadiaz-gly-betahdcph

9482: tolhs-24thiaz-bala-aspbzla

9483: phhs-oxadiaz-bala-zdapch

9484: ibhs-ithiadiaz-gly-psdapee

9485: ibhs-nme35pyr-gly-beta35dbph

9486: ibhs-24thiaz-gly-betabnaphth

9487: bhs-ithiadiaz-gly-betafph

9488: bhs-42nmeim-gly-betafluo

9489: phhs-25thiaz-bala-betatrif

01/283/02 / PB

9490: tolhs-nme35pyr-bala-betaph

9491: ibhs-25methiaz-bala-beta34dcph

9492: bim-24oxaz-gly-zdap

9493: bhs-25thiaz-bala-beta4bph

9494: bhs-25thioph-gly-betapy

9495: bhs-25methiaz-bala-psdapch

9496: bhs-25oxaz-nmgly-betadmph

9497: phhs-me25thioph-ala-betapy

9498: ibhs-oxadiaz-bala-betafu3

9499: ibhs-24thiaz-bala-betamethi

9500: phhs-24thioph-bala-betatrif

9501: tolhs-25oxaz-gly-betathio3

9502: bim-25thioph-gly-psdap

9503: phhs-ithiadiaz-bala-betahdbph

9504: tolhs-25oxaz-gly-betaomebendi

9505: phhs-me24thioph-ala-psdap

9506: ibhs-ithiadiaz-gly-betafph

9507: phhs-oxadiaz-bala-betaol

9508: bhs-ithiadiaz-ala-betadhbfu

9509: ibhs-oxadiaz-gly-betabnaphth

9510: bhs-nme35pyr-ala-betadhbfu

9511: bhs-ithiadiaz-nmgly-betaipro

9512: 2py-oxadiaz-bala-zdap

9513: phhs-25oxaz-bala-beta23meoph

9514: bhs-me24oxaz-bala-betapy

9515: ibhs-24thiaz-gly-zdap

9516: bhs-me25thioph-leu-psdap

9517: phhs-oxadiaz-bala-betafbph

9518: bhs-ithiadiaz-bala-betabmph

9519: bhs-25methiaz-gly-betaphethioa

9520: bhs-24thiaz-bala-suabu

01/283/02 / PB

347

9521: tolhs-25methiaz-bala-betacbph

9522: tolhs-25methiaz-gly-betaheph

9523: phhs-25thiaz-gly-beta34dcph

9524: impy-25methiaz-nmgly-psdap

9525: bhs-oxadiaz-nmgly-betabpy

9526: bhs-25thiaz-bala-zdap

9527: tolhs-24thiaz-gly-busu2be

9528: 2py-24thiaz-leu-psdap

9529: bhs-nme35pyr-gly-betadmoph

9530: ibhs-25thiaz-bala-betafluo

9531: tolhs-nme35pyr-gly-betahmph

9532: tolhs-oxadiaz-gly-betahb

9533: bhs-ithiadiaz-gly-betaheph

9534: phhs-oxadiaz-bala-betaomebendi

9535: bhs-oxadiaz-gly-zdap

9536: bhs-25methiaz-gly-betahdcph

9537: ibhs-25thiaz-bala-zdap

9538: tolhs-25methiaz-bala-betathiome

9539: phhs-ithiadiaz-bala-betaimide

9540: phhs-24thiaz-gly-betapyee

9541: tolhs-ithiadiaz-bala-betaphethioa

9542: ibhs-24thiaz-bala-zdap

9543: phhs-25thiaz-gly-betaomebendi

9544: bhs-25oxaz-bala-psdaptb

9545: bhs-25oxaz-gly-betaph

9546: ibhs-25methiaz-gly-betahc

9547: tolhs-25methiaz-bala-betab

9548: tolhs-nme35pyr-bala-betadcphch

9549: gua-25thioph-gly-betamesu

9550: tolhs-24thioph-bala-betadcphee

9551: bhs-oxadiaz-ala-betaoxaz

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348

9552: ibhs-25oxaz-gly-betathio3

9553: phhs-24thioph-gly-betafluo

9554: bim-25oxaz-gly-betameph

9555: bim-25methiaz-gly-aspibua

9556: bim-me25oxaz-bala-psdap

9557: ibhs-oxadiaz-gly-zdapch

9558: 2py-oxadiaz-bala-aspaba

9559: bhs-oxadiaz-nmgly-betainyl

9560: tolhs-25methiaz-bala-betaipro

9561: bhs-25fur-gly-betapy

9562: bhs-25thioph-ala-psdap

9563: ibhs-oxadiaz-gly-betadcphch

9564: phhs-25oxaz-bala-betafluo

9565: phhs-25oxaz-bala-betadbph

9566: ibhs-oxadiaz-gly-betaomebendi

9567: ibhs-nme35pyr-gly-betaphethio

9568: bhs-25oxaz-bala-betabpy

9569: phhs-25thiaz-bala-betaipro

9570: 2py-nme35pyr-ala-betapy

9571: ibhs-24thiaz-bala-betahb

9572: bhs-24thioph-gly-betaimide

9573: bhs-25methiaz-bala-betaoxope

9574: ibhs-ithiadiaz-bala-betahmph

9575: 2py-24thiaz-leu-zdap

9576: bhs-25methiaz-gly-betapym

9577: bhs-ithiadiaz-ala-betaoxaz

9578: ibhs-24thioph-bala-betaimide

9579: ibhs-24thioph-gly-beta23meoph

9580: bim-me24oxaz-gly-zdap

9581: tolhs-nme35pyr-gly-betahc

9582: bhs-25thiophme-gly-betapy

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349

9583: bhs-25oxaz-gly-betambiph

9584: phhs-25oxaz-bala-betadito

9585: phhs-25methiaz-gly-betatbuph

9586: tolhs-24thiaz-bala-betapytb

9587: impy-25thiaz-bala-betah35dc

9588: bhs-nme35pyr-bala-zdaptb

9589: 2py-26py-ser-zdap

9590: dhim-42pym-gly-betadcph

9591: 2py-me25thioph-bala-betadcph

9592: tolhs-oxadiaz-bala-betathiobe

9593: ibhs-24thiaz-bala-betaipr

9594: phhs-nme35pyr-bala-betahcbph

9595: gua-24thiaz-gly-betaipro

9596: tolhs-oxadiaz-bala-betatos

9597: phhs-24thiaz-bala-betatrif

9598: tolhs-ithiadiaz-gly-betadhbfu

9599: 2 pmhs-25methiaz-bala-zdap

9600: gua-24oxaz-gly-betabmph

9601: bhs-oxadiaz-bala-zdaptb

9602: bhs-oxadiaz-nmgly-betadhbfu

9603: phhs-25thiaz-gly-betahmo

9604: phhs-ithiadiaz-gly-betamethioph

9605: bhs-ithiadiaz-leu-zdap

9606: tolhs-24thiaz-gly-betapytb

9607: ibhs-24thioph-gly-betaet

9608: phhs-25thiaz-gly-betainyl

9609: tolhs-oxadiaz-bala-betathio3

9610: bhs-25oxaz-ala-betabnaphth

9611: bim-nme35pyr-gly-zdap

9612: 2py-25thioph-gly-betadcph

9613: phhs-24thioph-gly-betadcphee

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350

9614: ibhs-24thioph-gly-beta13bendi

9615: bhs-42pym-gly-zdap

9616: 2py-24im-bala-betapy

9617: phhs-25methiaz-gly-psdapee

9618: bhs-24im-leu-betadcph

9619: phhs-24thiaz-bala-betafphe

9620: tolhs-24thiaz-bala-psdap

9621: bhs-nme35pyr-bala-betapy

9622: impy-42nmeim-gly-beta13bendi

9623: phhs-25thiaz-bala-betadhbfu

9624: ibhs-24thiaz-bala-betabpy

9625: phhs-oxadiaz-bala-aspibua

9626: ibhs-nme35pyr-gly-betafu2

9627: 2 pmhs-42nmeim-bala-ibsdap

9628: bhs-25thiaz-gly-betahc

9629: bim-42pym-gly-betainyl

9630: bim-me25thiaz-gly-psdap

9631: phhs-ithiadiaz-bala-betafu3

9632: bhs-24thioph-nmgly-betathioph

9633: bim-42pym-gly-zdap

9634: ibhs-24thiaz-gly-betabmph

9635: phhs-24thioph-gly-beta23meoph

9636: phhs-24thiaz-gly-betadito

9637: phhs-25oxaz-gly-beta3quin

9638: bim-nme35pyr-gly-aspibua

9639: bim-oxadiaz-gly-aspibua

9640: tolhs-25thiaz-gly-betahcbh

9641: ibhs-ithiadiaz-gly-asppha

9642: impy-25oxaz-met-psdap

9643: ibhs-nme35pyr-bala-betahc

9644: 2py-25fur-gly-betadcph

351

01/283/02 / PB

9645: tolhs-24thioph-bala-betaomebendi

9646: gua-24thiaz-gly-betahmofu

9647: ibhs-25methiaz-bala-zdapch

9648: 2py-24thiaz-bala-zdap

9649: bhs-24thiaz-gly-beta4bph

9650: phhs-24thioph-gly-betahdcph

9651: bhs-42nmeim-bala-psdap

9652: phhs-25thiaz-gly-aspbzla

9653: 2py-24thioph-ala-betadcph

9654: bhs-24thiaz-ala-betahmph

9655: bhs-triaz-leu-zdap

9656: tolhs-nme35pyr-bala-betaftrif

9657: bhs-ithiadiaz-bala-beta13bendi

9658: ibhs-25methiaz-gly-betahmo

9659: ibhs-24thioph-gly-betahmofu

9660: bhs-25oxaz-bala-asppha

9661: tolhs-25methiaz-gly-betaftrif

9662: bhs-oxadiaz-gly-betacph

9663: phhs-25oxaz-gly-betabenfu

9664: dhim-24oxaz-ala-betadcph

9665: tolhs-25oxaz-bala-aspaba

9666: bhs-25thiaz-bala-psdaptb

9667: bhs-25oxaz-nmala-psdap

9668: 4 pmhs-24thioph-bala-betameph

9669: bhs-nme35pyr-bala-betahmo

9670: ibhs-nme35pyr-gly-betaanaphth

9671: dhim-52thiaz-ala-betapy

9672: bim-52thiaz-gly-psdap

01/283/02 / PB

352

The compounds after the column in the list above in each case represent, separated by a separator bar, the structural elements A, E, G and L, where the abbreviations have the following meanings:

A = Abbreviation A = Abbreviation 2nd thpym Α · ν \ -Ν Η dhim iii ^H 1 40 0 nmhs al · bim Coy 0 4pmhs Cry Η ° imhs 0 Λ H ₂ I <I hs crl · bhs 0 o / ChoA ojiAj ^h 1 nh ₂ sabhs Η η ₂ ν ί gua NH CrV ¹ bgua ίχΛ 2pmhs dhpyrr α> ι Η impy V _T v ^H V 0 ur ·Α · όΗ hyd We do o ibhs ο U ^Η 3pmhs X H.N N Η, Λ agua

355

1l = Abbreviation a = Abbreviation The dream dhthi / —N XI h H dimethpym Ch thazep η, Λ hts ^nc 'n xh Η cima Ch ''. thpy Η? Qf 0 pahs Xi phhs άϊ tolhs Ε = Abbreviation E = Abbreviation Η S 24thioph N-N oxadiaz .Μ Η nme35pyr . M 1 An ^V N H 42oxaz Η V / ai N- # Μ f cf me24im ι P ¢ / 1 35pyrazo νζ- ^ Λ Η 25thiophme H 24thiophme _t h'A Ν-Ν thiadiaz 25fur

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354

E = Abbreviation E = Abbreviation g / E 25thiaz 0 Η ru 52thiaz m n 0 1 \\ // 1 N-N triaz ς P, 1I Vn h 35thioph VN n 35fur Ί ^H + -N 1 o 42nmeim l ^K 4 ^s J ^Ν Λ · ι 0 24thiaz Ί ^H t 0 / a 23thioph ^{n Ν} Λ · ν 0 24thiazme 42py N 35py H 25py iWt Νχ ^ Ν 46pym n 9 i ' ^N W'b if ^N 24chin me25thiaz H me24thiaz ι-Wi · Ns> 24py l ^S U'l 26py Γγ ^ Α N ^> 24pym 42pym

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355

E = Abbreviation E = Abbreviation 26pyrazi 25methiaz 25thioph 4 0 53pyrazo 24oxaz η H ⁿ A 0 24im 0 25oxaz A H ^s ithiadiaz me25oxaz H me24oxaz ACrv 0 me25thioph H me24thloph ω / ¹ 2thioph

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356

G = Abbreviation G = Abbreviation u ⁰ giy in 0 γ leu phg M ⁰ n and iyi / 8 met m 0 ι · γ · ι ala H fl ι-γι hphe Η ι · ^ν Αί phe 1 θ νγι nmala U ο ΟΗ sir nmgly Α-Α 0 bala

01/283/02 / PB

L = Abbreviation L = Abbreviation _h Η betapy Αγγ ^0Η A ⁰ Cl Cl betadcph Η Oannes ^one Ϋ aspibua oh 0 NH 0 A aspaba Η | Ν ^ χ-χ, 0Η ό ° ιΊι betapbiph 1 ^j y-y ^{on H0} N ° cA ^ a betahdcph • 1 ^j y ^ ^-one Οχ beta34meoph l ^S Y ~ Y ° Yy 0 betaheph , ΧΟ • 1-Μγθ ^ 0 zdapee , xo zdaptb Mr Rücker 1 betameph 1 { ^Ν Ύ ^ γθΗ A ° 4 / ^N betampy • ^ γΎ ⁰ ”θό ° ί beta23meoph H t ^N Y * Y ^0H ill ⁰ betainyl

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358

L = Abbreviation L = Abbreviation I X O betatbuph • l ^K y ^ Y ^0H 0 ° betathioph X o 5 = ° x ^ O V / betaanaphth And? ·. ' P -o betaoxaz , H betambiph .XO 0 zdap , H -I ⁿ y ^z v ^oh A ° betabnaphth ..0 HN 0 Ι'Ν ^^ γΟΗ 0 psdap lVv ^0H ό ° betaph A H ^H ? ° 0 csdap ^H l | 2γγθγ betapytb H betadcphee

I

01/283/02 / PB

353

L = Abbreviation L = Abbreviation _n ΗΝ Ο [Ν ^ Α ^ ΟΗ 0 ibsdap A o X busu2be Η beta3quin And V-o betal 3bendi Η 1 ' ^ν ΆΑγ' ^{οη Nr} betadbph H betafbph } ^Κ γΎ ^0Η Α ° betacbph H betafluo Η (' ^Ν Ύ ^ γ ^0Η _Βι Α) ν betabpy ^ ΥΎ ^{0Η but} D ° betahcbph Ι ^Η γ-γ ^0Η Αι ⁰ Ν «^ Ν betapym Η ('ΝχΥΥχΟΗ A' betamethi 0,0 and η / ο ¹ h0 psdapch 0..0, S _C ΗΝ 0, ^ κΑζΦ psdaptb

01/283/02 / PB

360

L = Abbreviation L = Abbreviation Ι-Βγ-γΟΗ Cl betacthioph l-Vr ** ¹ fy betamethioph Η 4 ' ^Νχ γ ^χΖ ^' ^{0Η Ό} -1 betaomebendi H Ι ^ν ύ-r ^0H l ° θ betabenfu i- ^k yV ^h ά Br betabthioph ι · ^κ νγ ^0Η ΟγΙ 0 ψ CI betaoxope lVv ° ^H φ ° F betafph Α <γ ^0Η nAih ⁰ \ = / betaimide ΎγΎ ^0Η ό ° betafu2 Ό'ΥΎ ό ° betafu3 Η \ • Ί ^ Υ ^ νΟ'ν JL θ betadcphtb Η betadcphch -¾ ο X betathio3 ^ ΥΎ ^{0Η Nr} beta4bph ^ ΥΊί ^0Η Α ° betadmph Γ ^ γ ^0Η χΧ ° betadmoph

01/283/02 / PB

36ί

L = Abbreviation L = - Abbreviation 0 betathiobe l- ^a W ^0H HN ^{J 0} Occ χσ suabu In o I betathiome t ^K yy ^0H O '' betatos G-Q σ ' betaphethio ^ ΥΎ ^0Η O ^ OH) 0 ά ' betaphethioa ^ YY ^0H H0 ^{J 0} betaol * VY ^0H ύ ° betahph ^ γστ ^0Η ” ^th ° betahmph 1- ^κ γ-γ ^0Η j =? ° σ ⁴ betaamibe δ betabediox Η [.Νκ / γΟΗ γχι CI beta34dcph _FiC AA _CF> betadtrif I-Vy ⁰ ”α: betacph

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362

L = Abbreviation L = Abbreviation o χ U 0 _c X = / HN O I zdapch HN 0 psdapee ΤΌ 0 Η H ^ V ^0H JV ν ^0Η _t N Λ betabph . 0 |] betaftrif υ ⁴ Br CF ₃ Η H } Ν _γ Ύ ^0Η V In ^H Mr beta35dbph λ betabmph Ur Ur VG Η IV Ύ ^0Η H vs χχ, ΟΗ Λ betaibph X ⁰ betahmo I J A, If ^h Br HO ^ - 1 V χχ, ΟΗ H v V ^{Η <} Μ X ⁰ |] betahmofu HO ^ J J betahni οΑ II Λο k Ko ₂ Η H 1 · ^Ν γ Wh ^-he l-s χχ ^ ΟΗ hoJC 0 1 betahb hoJ X ⁰ π betahc Chh I ”see 4 II ci Η ι-γ 4r ^OH l ^N V ν ^0Η | ^ Ν 0 betampy 0 0 L & z betamesu 8 0 Η Γγ Wh ^-he In ^0H γ ' 0 J. betadito A 0 D NH betapyr EtO ^ ΌΕί N

01/283/02 / PB Coll

L = Abbreviation L = Abbreviation ^ γ ~ γ ^0Η CF ₃ 0 betatrif ^{H V N W 0H Β ^ γΌ} / 0 ¹ betabdimo iPr 0 betaipr RyY ^0H Et 0 betaet o betafphe R Σ Q ° \ ⁰ betadhbfu Ky ^{1 H0} Os ⁰ cXk betahbcph A ⁰ betaipro H Br'y'Br OH betahdbph ^{H 'i N rv 0H Cl ^} yOl OH betah35dc oan ^0M ό asppha <An ^0H Yu aspbzla H Ι = 4χΝ betapyee ^ι ττό betapych

In the table, Et stands for ethyl and iPr stands for / so-propyl.

The compounds of general formula I and the starting materials used to prepare them may generally be

01/283/02 / PB

364 obtained by organic chemistry methods known to those of skill in the art, as described in standard developments, for example, Houben-Weyl, '' Methoden der Organischen Chemie '', Thieme-Verlag, Stuttgart, or March '' Advanced Organic Chemistry '', 4th Edition, Wiley & Sons.

The compounds of formula I can be synthesized both by the "classical" method in solution by condensation of individual building blocks in solution and on a polymeric surface, in each case using reaction conditions known and appropriate for the particular reactions. It is also possible to use variants that are known per se but not listed here.

The purchase of individual fragments and the elimination of protective groups may find their place in known methods analogous to methods of peptide synthesis, as described in standard developments, for example, in Bodanszky's The Practice of Peptide Synthesis, 2nd Edition, Springer-Verlag 1994, and Bodanszky '' Principles of Peptide Synthesis '', Springer-Verlag 1984. Solid phase synthesis methods and applications are described, for example, in J. Am. Chem. Soc. 1972, 94, 3102 et seq., Int. J. Peptide Protein Res. 1990, 35, 161-214; Angew. Chem. 1992, 375-391, J. Med. Chem. 1994, 37, 1233, J. Med. Chem. 1994, 37, 1385, and Angew. Chem. 1996, 108, 2437-2488. A general overview of conventional peptide synthesis methods and a list of suitable reagents can be found in NOVABIOCHEM 1999 '' Catalog and Peptide Synthesis Handbook ''.

The general synthesis of the compounds of formula I is described in Schemes 1-8. Unless otherwise noted, all standard

01/283/02 / PB

365 materials and reagents can be purchased or can be obtained by conventional precursor methods that can be purchased.

Schemes 1-3 generally describe the synthesis of the compounds of formula I. The synthesis can generally be accomplished by the N-terminal extension of building block II (Scheme 1). Coupling from II to III gives IV, and the elimination of the protecting group SG3 at V and renewed coupling with VI leads to VII.

Conversely, type I compounds can also be prepared by C-terminal extension starting from building block VI. Coupling with VIII gives IX, and elimination of the SG2 protecting group and renewed coupling with II leads to VII (Scheme 2).

The compounds of general formula I are finally prepared by eliminating the SG1 protecting group in VII (Scheme 3). Synthesis schemes show radicals of carboxylic acid derivatives, such as the group -CO-R ¹ , a preferred embodiment of group Z, in the place of group T. Synthesis with the corresponding group Z takes place. in a similar way. In the case where the radicals R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , Q or A contain functional groups that affect the binding of said structural blocks, these functional groups are likely blocked by suitable protecting groups.

Said couplings may be effected by the addition of conventional coupling reagents using suitably protected amino and carboxylic acid derivatives (Y = OH in formulas III and VI). Another method involves using

01/283/02 / PB

366 pre-activated carboxylic acid derivatives, preferably carbonyl halides, symmetric or mixed anhydrides, or so-called active esters (Y = halide, active ester, anhydride; in formulas III and VI), which are commonly used for acylation of amines. These activated carboxylic acid derivatives can also be prepared in situ.

Couplings can generally be carried out in inert solvents in the presence of a binder, preferably from an organic base such as, for example, triethylamine, pyridine, diisopropylethylamine, Nmethylmorpholine, quinoline; it is advantageous to add an alkali metal or alkaline earth metal hydroxide, carbonate or bicarbonate or other low acid salt with alkali metals or alkaline earth metals, preferably potassium, sodium, calcium or cesium. The reaction time depends on the conditions used and is between a few minutes and 14 days and the reaction temperature is from 40 ° C to 140 ° C, preferably between -20 ° C and 100 ° C.

Examples of suitable inert solvents are carbohydrates such as hexane, heptane, petroleum ether, toluene, benzene or xylene; chlorinated carbohydrates such as trichloroethylene, 1,2 dichloroethane, tetrachloromethane, chloroform, dichloromethane; alcohols such as methanol, ethanol, isopropanol, n-propanol, pbutanol or tert-butanol; ethers such as diethyl ether, methyl tertbutyl ether, diisopropyl ether, tetrahydrofuran, dioxane; glycol ethers such as ethylene glycol monomethyl ether or monoethyl ether, ethylene glycol dimethyl ether; ketones such as acetone, butanone; amides such as dimethylformamide (DMF), dimethylacetamide or acetamide; nitriles such as acetonitrile; sulfoxides such as dimethyl sulfoxide; carboxylic acids such as formic

01/283/02 / PB

3BT acid or acetic acid; nitro compounds or nitromethane or nitrobenzene; esters such as ethyl acetate; water; or mixtures of said solvents.

SG protecting groups that may be used are all conventional protecting groups that are known to a person skilled in the art of peptide synthesis and are also described in the above standard works. The elimination of the protecting groups to obtain the compounds of formulas V, X and I is likely to occur under conditions known to one skilled in the art and described, for example, by Greene and Wuts in 'Protective Groups in Organic Synthesis', 2nd Edition , Wiley & Sons, 1991.

SG3 and SG5 are the so-called N-terminal amino protecting groups; preferred are Boc, Fmoc, benzyloxycarbonyl (Z), acetyl, Mtr.

SG1, SG2 and SG4 are suitable C-terminal hydroxyl protecting groups, preferably C1-C6-alkyl such as, for example, methyl, ethyl, tert-butyl, or more benzyl or trityl, or more particularly for SG1-polymer-linked protecting groups in the form of commercially available polystyrene resins such as, for example, 2-chlorotrityl chloride resin or Wang resin (from Bachem or Novabiochem).

The elimination of acid-labile protective groups (e.g., Boc, tert-butyl, Mtr, trityl) can be, depending on the protective groups used, with organic acids such as trifluoroacetic acid (TFA), trichloroacetic acid, trifluoroethanol or other inorganic acids such as

01/283/02 / PB

Perchloric acid, hydrochloric acid or sulfuric acid, sulfonic acids such as benzene or p-toluenesulfonic acid, acids are commonly used in excess. In the case of trityl, the addition of thiols such as, for example, thioanisole, ethanedithiol or thiophenol may be advantageous. The presence of an additional inert solvent is possible but not always necessary. Suitable and preferred inert solvents are organic solvents, for example carboxylic acids such as acetic acid; ethers such as THF or dioxane; amides such as DMF or dimethylacetamide; halogenated hydrocarbons such as dichloromethane; alcohols such as methanol, isopropanol; or water. The solvent mixtures mentioned above are also suitable. The temperature for these reactions is between -10 ° C and 50 ° C, preferably in the interval between

0 ° C and 30 ° C.

Essentially labile protective groups such as Fmoc are degraded by treatment with organic amines such as dimethylamine, | diethylamine, morpholine, piperidine as 5-50% solutions in CH ₂ Cl ₂ : or DMF. The temperature for these reactions is between -10 ° C and 50 ° C, preferably in the range between 0 ° C and 30 ° C.

I Acid protecting groups such as methyl or ethyl for §

preferably decomposed by hydrolysis with a base in inert j

j solvent. The bases used are preferably hydroxides ί

j of alkali metals or alkaline earth metals, preferably

I NaOH, KOH or LiOH; the solvents used are all | conventional inert solvents such as hydrocarbons such as hexane, heptane, petroleum ether, toluene, benzene or xylene; chlorinated hydrocarbons such as trichloroethylene, 1,2-dichloroethane, tetrachloromethane, chloroform, dichloromethane; alcohols such as

01/283/02 / PB 369 methanol, ethanol, isopropanol, n-propanol, n-butanol or tertbutanol; ethers such as diethyl ether, methyl tert-butyl ether, diisopropyl ether, tetrahydrofuran, dioxane; ether glycols such as ethylene glycol monomethyl ether or monoethyl ether, ethylene glycol dimethyl ether; ketones such as acetone, butanone; amides such as dimethylformamide (DMF), dimethylacetamide or acetamide; nitriles such as acetanitrile; sulfoxides such as dimethyl sulfoxide; nitro compounds such as nitromethane or nitrobenzene; water or mixtures of the solvents mentioned. The addition of a phase transfer catalyst may be advantageous depending on the solvent used or the mixture of solvents. The temperature for these reactions is generally between -10 ° C and 100 ° C.

Protective groups that can be eliminated by hydrogenolysis, such as benzyloxycarbonyl (Z) or benzyl, can be removed, for example, by hydrogenolysis in the presence of a catalyst (for example, a noble metal catalyst on an activated carbon surface). Suitable solvents are those mentioned above, in particular alcohols such as methanol, ethanol; amides such as DMF or dimethylacetamide; esters such as ethyl acetate. Hydrogenolysis is generally carried out at a pressure of 1-200 bar and at a temperature between 0 ° and 100 ° C; the addition of an acid such as acetic acid or hydrochloric acid may be preferred. The catalyst used is preferably 510% Pd on activated carbon.

01/283/02 / PB

3 | 0

Scheme 1:

VII

I-2

01/283/02 / PB

371

Scheme 2:

VII

01/283/02 / PB

372

Scheme 3:

D Й

01/283/02 / PB

373

The compounds of formulas II, III and VIII, and the starting materials for their preparation, can be either purchased or prepared by known methods.

For example, β-aryl- and hetarylamino acids can be synthesized by the method of Johnson et al., J. Am. Chem. Soc. 299, 1936, or Edwards et al., J. Org. Chem. 1979, 44, 3136-3140, from an aryl or hetaryl aldehyde, malonic acid and ammonium acetate.

Cole describes the synthesis of β-amino acids in general in Tetrahedron 1994, 50, 9517-9582. A method for the enantioselective synthesis of β-amino acids is described, for example, by Enders, Angew. Chem. Int. Ed. Engl., 1995, 34, 455-457. The preparation of enantiomerically pure 3-pyridinyl-alanine has been described by Rico et al., J. Org. Chem., 1993, 58, 7948-7951. 3-Ethynyl-alanine can be prepared by the method of Zablocki et al., J. Med. Chem. 1995, 38, 23782394. Suitable diaminopropionic acid derivatives may be purchased or prepared in a simple manner as described in WO 97/37655.

The conversion of the free β-amino acids or diaminopropionic acid derivatives into the corresponding N or C-protected derivatives can be accomplished by conventional organic chemistry methods, for example, as described by Bodanszky or Greene in the standard works mentioned above.

Aminocheterylcarboxylic acids and Aminocheterylcarboxylic esters of the general formula:

01/283/02 / PB

3? 4%> VY ° ^H _{or or} ⁰ 0Ο xi hixv-a which are used as starting materials in the synthesis of compounds of formula I can either be purchased or prepared according to the following examples:

ethyl 2-amino-1,3-thiazole-5-carboxylate in Kushner et al., J. Org. Chem. 1948, 13, 834 et seq .; methyl 2-amino-4-pyridinecarboxylate in Podany et al., J. Org. Chem. 1986, 51, 2988-2994; methyl 5-amino-pyridinecarboxylate in Hawkins et al., J. Org. Chem. 1949, 14, 328332; methyl 4-amino-2-pyrimidinecarboxylate in DE 2848912, methyl 6-amino-4-pyrimidinecarboxylate in Zh. Org. Khim. 1981, 17, 312317; ethyl 5-amino-1,3-thiazole-2-carboxylate in Adams et al., J. Chem. Soc. 1956, 1870-1873; methyl 4- (aminomethyl) -2-thiophenecarboxylate in Peschke et al., Bioorg. Med. Chem. Lett. 1997, 7, 1969-1972; 2amino-1,3-oxazole carboxylic acid in Foulis et al., J. Med. Chem. 1971, 14, 1075-1077; methyl 4-aminopyridine-2-carboxylate in Mostier et al., J. Org. Chem. 1955, 20, 283-285; methyl 2aminopyrimidine-3-carboxylate in Liebigs Ann. Chem. 1965, 209-211;

5-Amino-1,3,4-thiadiazole-5-carboxylic acid in Liebigs Ann. Chem. 1963, 3; 5-amino-1,3,4-triazole-5-carboxylic acid in US 3023210; 4-Aminopyrrol-2-carboxylic acid in J. Med. Chem. 1983, 26, 1042; 1-Methyl-3-aminopyrazole-5-carboxylic acid in Acta Chem. Scand. 1990, 44, 74; 1-Methyl-5-amino-3-carboxylic acid in Lee et al., J. Org. Chem. 1989, 54, 428.

Conversion of aminohetharylcarboxylic acids or aminohetharylcarboxylic esters of the general formula:

01/283/02 / PB

375

Ο

XI

XII in compounds of general formula:

or 0

XIV

XIII can be accomplished by methods known to one skilled in the art, as described, for example, in WO 97/08145. These building blocks can then be reacted either directly - in the case of the corresponding free carboxylic acids - or after elimination of the SG4 protecting group with the compounds of general formula V to obtain VII (Scheme 1) or VIII to obtain IX (for Y = OH, compound VI corresponds to compound XIII).

Schemes 4-7 describe, by way of example, multiple methods for administering A, the reaction conditions used in each case being known and appropriate to the particular reactions. Moreover, variants which are known per se but which are not mentioned herein may be used.

Ureas and thioureas (AE-1 to AE-3) may be prepared by conventional organic chemistry methods, for example as indicated in Scheme 4, by reaction of an isocyanate or

01/283/02 / PB

376 one thiocyanate with one amine, where appropriate in an inert solvent at elevated temperature (Houben-Weyl, volume VIII, 157 et seq.).

Scheme 5 shows by way of example the preparation of compounds of type AE-4 as described, for example, by Blakemoore et al. in Eur. J. Med. Chem. 1987 (22), 2, 91-100, or Misra et al. in Bioorg. Med. Chem. Lett. 1994, 4 (18), 2165-2170.

Unsubstituted or cyclic guanidine derivatives of the general formulas AE-5 and AE-6 can be prepared using reagents that can be purchased or easily obtained, as described, for example, in Synlett 1990, 745, J. Org . Chem. 1992, 57, 2497, Bioorg. Med. Chem. 1996, 6, 1185-1208; Bioorg. Med. Chem. 1998, 1185, or Synth. Comm. 1998, 28, 741–746.

It is possible to prepare compounds of general formula AE-7 by analogy with US 3,202,660, and compounds of formula AE-9, AE-10, AE-11 and AE-12 by analogy with WO 97/08145. Compounds of formula AE-8 can be prepared as shown in Scheme 6, for example, by the method described by Perkins et al., Tetrahedron Lett. 1999, 40, 1103-1106. Scheme 6 gives an overview of the synthesis of said compounds.

The compounds of general formula AE-13 can be prepared by analogy with Froeyen et al., Phosphorus Sulfur Silicon Relat. Elem. 1991, 63, 283-293, and AE-14, by analogy with Yoneda et al., Heterocycles 1998, 15, No. 2. 1, Spec. Issue, 341-344, as shown in Scheme 7. The corresponding compounds may also be prepared by analogy with WO 97/36859.

01/283/02 / PB

377

As shown in Scheme 8, an alternative reaction of the compounds of general formula IX with XV is possible to obtain the compounds of general formula XVI which, after removal of the SG5 protecting group, are converted to the compounds of type VIII by the methods described in WO 97 / 08145 and Schemes 2-5. In the case where R ¹ is C ¹ -C ₄ -alkoxy or benzoxy, the compounds of general formula VIII correspond directly to the compounds of type I.

378

01/283/02 / PB

it f

X

Oh

379

01/283/02 / PB

LO ra

O 'C' 0 ω ο ι ο II ο ι α>

Pyridine

r-t CN

X and

About II at

MS X υ

z-o

X

380

01/283/02 / PB

381

01/283/02 / PB as of Scheme 6

N M

X X

2 +

«A t

With "About"

II

MNMWMN

01/283/02 / PB

Scheme 7

382

383

01/283/02 / PB

Scheme 8

ΙΙΛ

01/283/02 / PB

384

The invention also relates to pharmaceutical preparations for oral and parenteral use containing at least one compound of formula I in addition to conventional pharmaceutical excipients.

The compounds of the invention may be administered orally or parenterally (subcutaneously, intravenously, intramuscularly, intraperitoneally) in a conventional manner. Administration can also be performed under pressure or sprays through the nasopharyngeal space.

The dose depends on the age, condition and weight of the patient and the route of administration. The daily dose depends on the active ingredient and is usually between about 0.5 and 50 mg / kg body weight when administered orally and between about 0.1 and 10 mg / kg body weight when administered parenterally.

The new compounds can be used in conventional solid or liquid pharmaceutical forms, for example, uncoated or (film-coated tablets, capsules, powders, granules, suppositories, solutions, ointments, creams and sprays. They are prepared in the usual way. this purpose can be obtained by conventional pharmaceutical excipients such as tablet binders, blowing agents, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solubilizers Firs, slow-release agents, antioxidants and / or propellant gases (cf. H. Sucker et al: Pharmazeutische Technologie, Thieme-Verlag, Stuttgart, 1991).

01/283/02 / PB 385 contain the active ingredient in an amount of 0.1 to 90% by weight.

The invention further relates to the use of compounds of formula I for the preparation of medicaments for the treatment of diseases. The compounds of formula I can be used to treat diseases in humans and animals. The compounds of formula I bind to integrin receptors and thus may be used as integrin receptor antagonists and for the preparation of medicaments for the treatment of diseases involving the integrin receptor.

The compounds of formula I are preferably connected to ssurz integrin receptor and thus may be used as antagonists stsfz integrin receptor and for treating diseases in which is included a _v p3 integrin receptor.

The compounds of formula I are preferably used for the treatment of the following diseases:

cardiovascular disorders such as atherosclerosis, restenosis after vascular disorders and angioplasty (neointima formation, smooth muscle migration and proliferation), acute renal disease associated with angiogenesis microangiopathies such as, for example, diabetic angiopathy,

01/283/02 / PB

386 platelet-mediated vascular occlusions, arterial thrombosis, stroke, reperfusion injury after myocardial infarction or stroke, cancer, such as in tumor metastases or tumor growth (tumor-induced angiogenesis), osteoporosis (bone marrow and osteoporosis) osteoclasts to bone matrix), high blood pressure, psoriasis, hyperparathyroidism, Paget's disease, malignant hypercacemia, metastatic osteolytic lesions, inflammation, wound healing, cardiac insufficiency, congestive heart disease CHF, and for antiviral, antiparasitic or antibacterial therapy and prophylaxis (adhesion and internalization).

The compounds of formula I may advantageously be administered in combination with at least one other compound in order to achieve an improved therapeutic effect for indication potential. These other compounds may have the same or different mechanism of action as the compounds of formula I.

The pharmaceutical preparations may therefore include, in addition to the compounds of formula I, the usual pharmaceutical excipients, at least one other compound, depending on the indication selected in each case from one of the following 10 groups.

«Η

ItgH ·

01/283/02 / PB 387

Hole 1:

Inhibitors of thrombocyte adhesion, activation or aggregation, such as acetylsalicylic acid, lysine acetylsalicylate, piracetam, dipyridamol, abcyximab, thromboxane antagonists, fibrinogen antagonists, such as, for example, tirofibin that prevent thrombin activity or formation, such as inhibitors of Ila, Xa, Xia, IXa or Vila, platelet activating antagonists, and selective antagonists for the treatment of thrombin platelet-mediated vascular occlusion or thrombosis, or group 2:

platelet activation or aggregation inhibitors, such as GPIIb / IIIa antagonists, thrombin inhibitors or factor Xa inhibitors or ADP receptor antagonists, serine protease inhibitors, fibrinogen-reducing compounds, selectin antagonists, ICAM-antagonists ,AM-antagonists adhesion inhibitors of transmigration through the walls of blood vessels, fibrinogen-modulating compounds such as streptokinase, tPA, plasminogen activating stimulants, TAFI inhibitors, Xia inhibitors or PAI-1 antagonists, inhibitors of complement factors "AAM

01/283/02 / PB 388 endothelin receptor antagonists, tyrosine kinase inhibitors, antioxidants and interleukin 8 antagonists for the treatment of myocardial infarction or stroke, or group 3:

one-antagonist,

ACE inhibitors,

Angiotensin receptor antagonists,

Endopeptidase inhibitors,

Beta Blockers,

Calcium channel blockers,

Phosphodiesterase inhibitors and

Caspase inhibitors

For treatment of congestive heart disease, or group 4:

thrombin inhibitors, factor Xa inhibitors, inhibitors of the coagulation pathway metabolism leading to the formation of thrombin, such as heparin or low molecular weight heparins, platelet adhesion inhibitors, activation or aggregation, such as GPIIb-antagonists vWF or GPIb-mediated adhesion and activation, endothelin receptor antagonists, nitric oxide synthase inhibitors,

CD44 antagonists,

01/283/02 / PB 389

Selectin antagonists,

MCP-1 antagonists, i

Inhibitors of signal transduction in proliferating cells, EGF, PDGF, VEGF or bFGF mediated cellular antagonists and antioxidants for the treatment of restenosis following vascular disorders or stent implantation or j

I ί group 5:

!

EGF, PDGF, VEGF j or bFGF mediated cellular antagonists | heparin or low molecular weight heparins other than GAGs, ß MMPs inhibitors, j selectin antagonists, | endothelin antagonists, ACE inhibitors, Angiotensin Receptor Antagonists and Glycosylation Inhibitors or AGE Inhibitors

I

The formation and antagonists of their receptors, such as,

RAGE,

For the treatment of diabetic angiopathies, or

Group I 6:

lipid-lowering compounds, selectin antagonists, ICAM-1 or VCAM-1 heparin antagonists or low molecular weight heparins or other GAGs, inhibitors of MMPs,

01/283/02 / PB

390 endothelin antagonists, apolipoprotein A1 antagonists, cholesterol antagonists,

HMG-CoA reductase inhibitors,

ACAT inhibitors,

ACE inhibitors,

Angiotensin receptor antagonists,

Tyrosine kinase inhibitors,

Protein kinase C inhibitors,

Calcium channel blockers,

LDL stimulators of receptor function,

Antioxidants and

Free radical scavengers

For the treatment of atherosclerosis or group 7:

cytostatic or antineoplastic compounds, compounds that inhibit proliferation, such as kinase inhibitors and heparin or low molecular weight heparins or other GAGs for the treatment of cancer, preferably to inhibit tumor growth or metastases, or group 8:

anti-resorptive therapy compounds, hormone replacement therapy compounds such as estrogen or progesterone antagonists, recombinant human growth hormone, bisphosphonates such as alendronate calcitonin therapy compounds,

01/283/02 / PB 391 calcitonin stimulants, calcitonin channel blockers, bone formation stimulants such as growth factor antagonists, interleukin-6 antagonists and

Src tyrosine kinase inhibitors

For the treatment of osteoporosis, or

Group 9:

TNF antagonists, VLA-4 or VCAM-1 antagonists, LFA-1, Mas-1 or ICAMs antagonists, complement inhibitors, immunosuppressants, interleukin-1, -5 or -8 antagonists and dihydrofolate reductase inhibitors for the treatment of rheumatitis , or group 10:

collagenase,

PDGF antagonists and

MMPs for improved wound healing.

A pharmaceutical composition comprising at least one compound of formula I, wherein the appropriate excipients and at least one other compound selected in each of the groups above, as the indication indicates, is a combined administration of at least one of the compounds by

01/283/02 / PB

392 formula I with at least one other compound selected for each of the cases from one of the groups described above and, where appropriate, pharmaceutical excipients.

The combined administration can be accomplished by a mixture of substances comprising at least one compound of formula I, wherein the appropriate pharmaceutical excipients and at least one other compound selected from one of the groups above, depending on the indication, but also spatially j and / or temporarily separately.

ί (j

In their spatially and / or temporarily separate administration, the compounds of the pharmaceutical preparation, the compounds of formula I and the compounds selected from one of the above groups are administered spatially and / or temporarily separately.

For the treatment of restenosis after vascular injury or stent placement, the compounds of formula I may be administered alone or in combination with at least one compound selected from group 4 locally at the affected sites. An advantage may be the coating of stents with these compounds.

For the treatment of osteoporosis, the use of the compounds of formula I in combination with anti-resorptive or hormone replacement therapy may be advantageous.

The invention accordingly relates to the use of the aforementioned pharmaceutical preparations for the preparation of medicines for the treatment of diseases.

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393

In a preferred embodiment, the invention relates to the use of said combination pharmaceutical preparations for the preparation of medicaments for the treatment of

Platelet-mediated vascular occlusion or thrombosis

When using compounds of group 1,

Myocardial infarction or stroke

When using compounds of group 2,

Congestive heart damage

When using compounds of group 3,

Restenosis after vascular injury

When using compounds of group 4,

Diabetic angiopathies

When using compounds of group 5, atherosclerosis using compounds of group 6, cancer using compounds of group 7, osteoporosis using compounds of group 8, rheumatoid arthritis using compounds of group 9,

01/283/02 / PB

394 wound healing using group 10 compounds.

The following examples illustrate the invention, the selection of these examples is not limiting.

I. Examples of synthesis

I.A Precursors

Obtaining building blocks L

3- (4-Methylphenyl) -p-alanine

4-Methylbenzaldehyde (30 g, 0.25 mol) was added to 500 ml of ethanol and after addition of malonic acid (25.9 g, 0.25 mol) and ammonium acetate (28.8 g, 0.374 mol), the mixture was refluxed for 8 h. After completion of the reaction, the mixture was cooled to 5 ° C and the resulting precipitate was filtered by suction, washed with cold ethanol and diethyl ether and dried in an oven at 40 ° C.

19.9 g; ESI-MS [M + H ⁺ ] = 180.

Ethos-3- (4-Methylphenyl) -p-alanine

3- (4-Methylphenyl) -p-alanine 1 (7 g, 39.6 mmol) was dissolved in a mixture of 160 ml of aqueous 10% Na ₂ CO ₃ solution and 50 ml of THF. Then Fmoc-CI (10.31 g, 39.8 mmol) - dissolved in 40 ml of THF - was added, and the mixture was stirred at room temperature overnight. The reaction mixture was worked up by adjusting pH 2 with concentrated HCl and extracted twice with diethyl ether. The combined organic phases were then dried (Na ₂ SO ₄ ) and concentrated, and the residue was crystallized from diethyl ether / cyclohexane and dried. In this way 14 g of white salt are obtained.

ESI-MS [M + H ⁺ ] = 402 am

01/283/02 / PB

395

Obtaining building blocks AE

Ethyl 2 - {[(benzylamino) carbonyl] amino} -1,3-thiazole-4-carboxylate Ethyl 2-amino-1,3-thiazolecarboxylate (1.6 g, 9.82 mmol) and benzyl isocyanate (1.31 g, 9.83 mmol) heated to reflux at 10 ml of CH ₂ Cl ₂ for 7 h. After completion of the reaction, the mixture was concentrated. Chromatography of the resulting residue) on silica gel (CH ₂ Cl ₂ / CH ₃ OH 2%) shows 2.4 g of the compound.

ι j

j ϊ

I 2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazole-4-carboxyl

I acid j Ethyl 2 - {[(benzylamino) carbonyl] amino} -1,3-thiazole-4j carboxylate (2.4 g, 7.86 mmol) was suspended in 10 ml CH ₃ OH and 1 ml of H ₂ O and after addition of LiOH (0.18 g, 7.86 mmol) was stirred at room temperature for 18 h. After completion of the reaction, 20 ml of H ₂ O was added, the pH was brought to 1 with concentrated HCl and the resulting salt was filtered by suction and dried.

j 1.3 g; ESI-MS [M + H ⁺ ] = 278 i

Ethyl (2 - {[(benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetate The reaction was carried out analogously to ethyl 2-amino-1,3-thiazol-4-yl acetate (1.25 g, 9.39 mmol). Chromatography gave 2.8 g of the compound.

(2 - {[(Benzylamino) carbonyl] amine} -1,3-thiazol-4-yl) -acetic acid

The reaction was carried out analogously to ethyl (2 {[(benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetate (2.8 g, 8.77 mmol) to give 1.9 g of the compound as a white salt;

01/283/02 / PB

396

ESI-MS [M + H ⁺ ] = 292.

2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazole-5-carboxylic acid

a) Methyl chloroacetate (32.6 g, 0.30 mol) and methyl formate (25.2 g, 0.42 mol) dissolved in ether (300 ml) were added dropwise to a cooled (0 to 10 ° C) solution of potassium ethanolate (29.9 g, 0.32 mol) in 80 ml of ethanol. The resulting suspension was stirred at 5 ° C for 1.5 h and at room temperature for 12 h. The resulting salt was filtered off and washed with diethyl ether. The residue was dissolved in H ₂ O, acidified to pH 3 with HCl (10

N) at 4 ° C and extracted with diethyl ether. The combined organic fractions were dried, filtered and evaporated to dryness; 12.7 days

b) Ethyl formyl chloroacetate (10.0 g, 66.42 mmol) and urea (4.4 g, 73.97 mmol) were refluxed in 60 ml of H ₂ O for 3.5 h. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. Chromatography (MPLC, RP, Chromasil 100 C18, gradient 1 to 11% acetonitrile) of the residue obtained gave 0.66 g of the compound.

c) Ethyl 2-amino-1,3-oxazole-5-carboxylate (0.3 g, 1.92 mmol) and benzyl isocyanate (0.26 g, 1.92 mmol) were refluxed in 15 ml of toluene for 8 h. After completion of the reaction, the mixture was washed with water (15 ml), extracted with 5% citric acid (2 x 15 ml) and shaken with H ₂ O. The organic phase was dried and concentrated. The mixture (1.27 g) of benzylamine, dibenzylurea and the required product (25%

01/283/02 / PB

397 purity) was precipitated from ethyl acetate and reacted without further purification.

d) Ethyl 2 - {[(benzylamino) carbonyl] amino} -1,3-oxazole-5carboxylate (0.35 g, 25% purity) was suspended in 20 ml CH 3 OH and 20 ml H ₂ O and, after addition of NaOH (1 N, 2.56 mmol) was stirred at 35 ° C for 6 h. After completion of the reaction, the mixture was concentrated and the aqueous phase was acidified to pH 2 with HCl (2 N) extracted exhaustively with ethyl acetate. The combined organic phases were dried, filtered and concentrated. Stirring in acetonitrile yields 136 mg of the compound; ESI-MS [M + H +] = 262.05.

2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazole-4-carboxylic acid

a) Bromoethyl pyruvate (59.7 g, 0.306 mol) and urea (27.6 g, 0.46 mol) were refluxed in 220 ml of ethanol for 24 h. The mixture was evaporated, and the residue was taken up in ch 20 ml of H ₂ O, brought to pH with a solution of 1N NaOH and extracted with CH ₂ Cl ₂ . Concentration of the organic phases and trituration of the residue with diethyl ether gave 12.3 g of the free base; ESI-MS [M + H +] = 157.05.

Ether HCl was added to the mother fluid at 10 ° C. This results in an additional 11.4 g of the ester as hydrochloride.

b) 4 g of ethyl 2-amino-1,3-oxazole-4-carboxylate were refluxed with benzyl isocyanate (3.75 g; 0.13 mmol) and 3.3 g of diisopropylethylamine in 60 ml of toluene for 1 h. After the reaction is complete, the mixture is evaporated and the residue is taken up in

01/283/02 / PB 398

CH ₂ Cl ₂ and washed with 1Ν HCl and saturated NaCl solutions. Drying of the organic phase, concentration and trituration of the residue in methyl tert-butyl ether gave 4.6 g of white salt; ESI-MS [M + H ⁺ ] = 290.05.

c) 4.3 g of ethyl 2 - {[(benzylamino) carbonyl] amino} -1,3-oxazole-4carboxylate in 120 ml of 2: 1 dioxane / H ₂ O are mixed with 1.4 g ΐ

KOH and refluxed for 2 h. Concentration of the mixture and acidification with 2N HCl gave a white precipitate, which was filtered off by suction, washed with acetone and | is dried.

! 3.38 g; ESI-MS [M + H +] = 262.05.

i

I

I 4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrole-2I carboxylic acid

Methyl 4-amino-1-methylpyrrole-2-carboxylate (4 g, 26 mmol) was suspended in 40 ml of toluene and 70 ml of THF, and 1 eq of benzyl isocyanate was added as a solution in 10 ml of THF. The mixture was stirred overnight and the resulting precipitate is filtered off. The mother liquor was concentrated, the residual oil was mixed with diethyl ether, and the resulting precipitate is filtered off. Combining the precipitate yields 5.16 g; ESI-MS: M + H + = 288

7.18 g (25 mmol) of methyl ester was dissolved in 150 ml in THF, and 2 eq LiOH dissolved in water were added. The mixture was stirred at room temperature for 3 h. It is then neutralized, concentrated and acidified with HCl, and the white precipitate is filtered off by suction. Washing with H ₂ O and crystallisation of j about 100 ml of ethanol gave 3.90 g; ESI-MS: M + H ⁺ = 274.0.

l

5 - {[(Benzylamino) carbonyl] amino} thiophene-2-carboxylic acid

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399

a) 7.76 ml of thionyl chloride at 0 ° C were added dropwise to 85 ml of methanol at 0 ° C. 16.8 g (97 mmol) of 2-nitrothiophene-5-carboxylic acid were added portionwise to this mixture, which was then stirred at room temperature for 5 h. It was then stirred at 40 ° C for 6 h. After cooling, the mixture was mixed with ice water, and the precipitate was filtered off, washed with water and taken up in ethyl acetate. The phases were separated and the organic phase was washed 4x with water, dried with Na ₂ SO ₄ and concentrated (16.45 g).

b) 9.2 g (49 mmol) of methyl 2-nitrothiophene-5-carboxylate was dissolved in 600 ml of glacial acetic acid and added at 40 ° C, 27.45 g of iron powder (Merck, Fe by reduction) in portions. After a few hours, the salt was filtered off by succinate and washed with glacial acetic acid, ethyl acetate and dichloromethane. The filtrates were combined, dried with Na ₂ SO ₄ and concentrated. The oily residue was taken up in diethyl ether and the hydrochloride precipitated with 6N isopropanol HCl. Filtration by succination and drying gave 5.80 g.

c) 5.80 g (30 mmol) of aminothiophene are placed in 50 ml of toluene c

10.2 ml diisopropylethylamine and 85 ml THF. After the addition of 1 eq benzyl isocyanate, the mixture was stirred overnight and then refluxed for about 13 h, and the black solution was concentrated, taken up in ethyl acetate and extracted with 1N HCl, water and brine. saturated NaHCO ₃ . The aqueous phases are discarded. The resulting precipitate was filtered off, and the mother liquor was dried with Na ₂ SO ₄ and concentrated to 20 ml. The precipitate formed is filtered off

01/283/02 / PB

400 and washed with cold ethyl acetate. 6.70 g; ESI-MS: M + H ⁺ = 291.0.

d) 6.6 g (22.8 mmol) of methyl ester were dissolved in 150 ml of THF, and 1.1 g of LiOH dissolved in water were added. After 3 h, another 0.55 g of LiOH was added and the mixture was stirred at 60 ° C for 16 h. After concentration and extraction of the residue with ethyl acetate, the aqueous phase was decolorized with activated carbon and acidified with HCl, and the precipitated product was filtered off. After drying, 4.5 g remain; ESI-MS: M + H + = 277.0.

5 - {[(Benzylamino) carbonyl] amino} -4H-1,2,4-triazole-3-carboxylic acid

a) 100 ml of methanol was mixed with 10.9 ml of thionyl chloride at 0 ° C and then, at room temperature, 12.81 g (100 mmol) of 1,2,4-triazole-5-carboxylic acid hemihydrate were added. The reaction mixture was stirred at room temperature for 16 h, concentrated and mixed with 100 ml of saturated NaHCO ₃ solution. The volumetric precipitate was filtered off by suction, released from ethyl acetate in vacuo and recrystallized from 200 ml of water. 10.51 g; ESI-MS: M + H + = 143.0.

b) 10.35 g (72.9 mmol) of aminotriazole was dissolved in 350 ml of toluene, 16 ml of diisopropylethylamine and 85 ml of THF and after addition of 1.11 eq benzyl isocyanate, the mixture was refluxed for 5 h. The solution was concentrated and taken up in ethyl acetate, and the organic phase was extracted with 1N hydrochloric acid, H ₂ O (2x), saturated NaHCO ₃ solution and H ₂ O (2x). The organic phase was dried with Na ₂ SO ₄ and concentrated, and

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The 401 residue was triturated with diethyl ether. 15.7 g; ESI-MS [M + H +] =

276.1.

c) 15.42 g (56.1 mmol) of methyl triazolecarboxylate were dissolved in 360 ml of THF and then 2.55 g of LiOH in 250 ml of water was added. After 4 h, the mixture was concentrated, mixed with ethyl acetate and acidified with HCl, and the organic phase was extracted with water, saturated NaHCO ₃ solution and water. The product of the precipitate is filtered off with suction and dried.

I 1.50 g;

ESI-MS [M + H +] = 262.0.

ί

I

4 - {[(Benzamino) carbonyl] amino} thiophene-2-carboxylic acid ί a) 19.24 g of thionyl chloride was added dropwise to 160 ml of methanol j at 0 ° C, and then 25.45 g (147 mmol) of 2-nitrothiophene -4j carboxylic acid is added in portions. The mixture was stirred at 45 ° C for 4.5 h. After cooling, 160 ml of water were added and the resulting precipitate was filtered off by succinate. 26.75 9 ·

B) 21.5 g (115 mmol) of nitrothiophene were placed in 1.4 I glacial acetic acid and heated to 40 ° C and 10 eq of iron (Merck obtained by reduction) was added in portions. After a few hours, the salt was filtered off by succination and washed with glacial acetic acid, ethyl acetate and dichloromethane, the mother liquor was mixed with twice the water and extracted 4x with dichloromethane, and the combined organic phases were dried with Na ₂ SO ₄ and dried. concentrate. The residue was taken up in diethyl ether and converted to 6N hydrochloride

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402 isopropanol HCl. Filtration with succination and drying gave 13.3 g.

¹ H-NMR (d 6 -DMSO) d (ppm) = 3.75 (s, 3H, OCH ₃ ), 6.75, 7.70 (each s, 1H, Ar-H))

c) 20.4 g (105.3 mmol) of aminothiophene were placed in 530 ml of toluene, 85 ml of THF and 27.2 g of diisopropylethylamine. 14.0 g of benzyl isocyanate were then added, and the mixture was stirred at room temperature for 16 h and then refluxed for 3 h. The black solution was concentrated, taken up in ethyl acetate and extracted with 1N HCl, water and saturated NaHCO ₃ solution. The organic phase was dried with Na ₂ SO ₄ and concentrated, and the residue triturated with diethyl ether; 21.0 days

d) 28 d (96.2 mmol) of thiophene methyl ester were dissolved in 600 ml of THF, and 4.62 g of LiOH in 350 ml of water were added. After 3 h at 60 ° C, the THF was removed in vacuo and the aqueous residue was extracted 2x with ethyl acetate. The aqueous phase was acidified with hydrochloric acid, and the precipitated product was filtered off with suction. For purification, it was taken up in NaOH solution, treated with activated carbon and filtered off with suction through Celite. Acidification with HCI, filtration with suction and drying afforded 20.0 g; ESI-MS: [M + H ⁺ ] = 277.0.

5 - {[(Benzylamino) carbonyl] amino} -2-furancarboxylic acid

a) 10 g (70.86 mmol) of methyl 5-aminofuran-2-carboxylate were dissolved in 200 ml of THF, 10.07 g of Hunig base was added and then 18.87 g (141.7 mmol) of benzyl isocyanate was added dropwise. The solution was stirred at 30 ° C for 6 h and then concentrated under high vacuum, and the residue was taken up in

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403 ethyl acetate. Wash with 1 N HCl, water and saturated NaCl solution. The organic phase was dried and concentrated. The residue was mixed with a little methanol, boiled briefly and cooled in an ice bath. The salt was filtered off by succination, washed with a little cold methanol and dried (14.0 g).

ESI-MS [M + H ⁺ ] = 408.15

B) 10.50 g (25.77 mmol) of methyl

The 5- {bis [(benzylamino) carbonyl] amino-2-furancarboxylate was suspended in 100 ml of THF, and 18.5 g (773 mmol) of LiOH in 100 ml of water were added. The suspension was stirred at room temperature for 20 h. Ethyl acetate and water were added to the mixture, and the aqueous phase was separated and washed twice with ethyl acetate. The pH was then adjusted to 1 with 10% HCl, and the precipitated salt was filtered off, washed with water and dried (5.92 g).

ESI-MS [M + H ⁺ ] = 261.05

Examples I.B

Synthesis of Compounds of Formula I (A-E-G-L)

Example 1

N - ({[(2 - ([(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) N-alanine (1)

1.1 N- [3- (4-Methylphenyl) -p-alanine] trityl resin

3.0 g of Cl-trityl-resin was suspended in dichloromethane and, after the addition of diisopropylethylamine (1.64 ml, 9 mmol) and 3- (4-methylphenyl) -p-alanine (1.45 g, 3.6 mmol), shaken RT overnight. Then another 1.5 ml was added

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404 diisopropylethylamine and 9 ml methanol, and the mixture was shaken for another 30 min. The resin was filtered off by succinate and washed with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ . To eliminate the Fmoc protecting group, the resin was shaken in 1: 1 piperidine / CH ₂ Cl ₂ at RT for 20 min, filtered by succination and washed 5x with CH ₂ Cl ₂ . The cleavage of the protective group is carried out in total 2x. The resin was then washed again with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ and dried in an RT oven overnight. The final weight was 3.44 g (load: 0.896 g / mmol).

1.2 N-Cl-[3- (4-Methylphenyl) -p-alanine] -trityl-resin N- [3- (4-Methylphenyl) -p-alanine] -trityl-resin (111.6 mg, 0.1 mmol) was suspended in dimethylformamide and, after adding Fmoc-Gly-OH (59.5 mg, 0.2 mmol), diisopropylethylamine (34.4 ml, 0.2 mmol) and TBTU (64.4 mg, 0.2 mmol), was shaken at room temperature for 48 h. The resin was then filtered off by succination and washed with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ . To eliminate the Fmoc protecting group, the resin was shaken in 1: 1 piperidine / CH ₂ Cl ₂ at RT for 20 min, filtered off by succination and washed 5x with CH ₂ Cl ₂ . The cleavage of the protective group is carried out twice in total. The resin was then washed again with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ and dried in an oven at RT (RT) overnight.

1.3 N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -p-alanine (1)

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405

0.03 mmol of H-Cl- [3- (4-methylphenyl) -p-alanine] -trityl-resin was suspended in DMF and, after addition of 2 {[(benzylamino) carbonyl] amino} -1,3-thiazole-4 -carboxylic acid (17.5 mg, 0.06 mmol), diisopropylethylamine (10.32 ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol) were shaken overnight at room temperature. The resin was then filtered off by succination and washed with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ . Then, for cleavage of the resin, 1.5 ml of 1: 1: 3 trifluoroethanol / acetic acid / CH ₂ Cl _{2 was added} and the mixture was again shaken at room temperature for 1 h. Evaporation of the cleavage solution, addition of 2 ml of acetic acid to the residue and lyophilization gave 5 mg of the required product, ESI-MS [M + H ⁺ ] = 496.

Example 2 N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] amino} acetyl) -3- (4-methylphenyl) -p-alanine (2 )

0.03 mmol of H-Cl- [3- (4-methylphenyl) -p-alanine] -trityl-resin was suspended in DMF and, after addition of (2 {[(benzylamino) carbonyl] amino} -1,3-thiazole- 4-yl) acetic acid (17.5 mg, 0.06 mmol), diisopropylethylamine (10.32 ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol) were shaken overnight at room temperature. The resin was then filtered off by succination and washed with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ . Then, to cleave the resin, 1.5 ml of a 1: 1: 3 mixture of trifluoroethanol / acetic acid / CH ₂ Cl _{2 was added} and the mixture was again shaken at room temperature for 1 h. Evaporation of the cleavage solution, addition of 2 ml of acetic acid to the residue

01/283/02 / PB 406 and lyophilization gave 8 mg of the desired product, ESI-MS [M + H ⁺ ] = 510.

The cleavage solution was then evaporated to dryness, and the residue was taken up in ethyl acetate and lyophilized.

Example 3 N - ({[(2 - [[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) -3- (3-pyridinyl) -p-alanine (3 )

3.1 N- [3- (3-Pyridinyl) -p-alanine] -trityl-resin

A procedure analogous to the preparation of N- [3- (4methylphenyl) -p-alanine] -trityl-resin.

N- [3- (3-Pyridinyl) -p-alanine] -trityl-resin N- [3- (3-Pyridinyl) -p-alanine] -trityl-resin (106.4 mg, 0.1 mmol) was suspended in dimethylformamide and, after the addition of Fmoc-Gly-OH (59.5 mg, 0.2 mmol), diisopropylethylamine (34.4 ml, 0.2 mmol) and TBTU (64.4 mg, 0.2 mmol), shaken at room temperature for 48 h. The resin was filtered off by succinate and washed with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ . To eliminate the Fmoc protecting group, the resin was removed in 1: 1 piperidine / CH ₂ Cl ₂ at RT for 20 min, filtered off by succination and washed 5x with CH ₂ Cl ₂ . The cleavage of the protective group is carried out for a total of 2 times. The resin was then washed again with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ and dried in an oven at RT overnight.

01/283/02 / PB 407

3.2 N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) -3- (3-pyridinyl) -p-alanine (3) 0.03 mmol of H-Cl- [3- (3-pyridinyl) -p-alanine] -trityl-resin was suspended in DMF and, after addition of 2 {[(benzylamino) carbonyl] amino} -1,3-thiazole-4 -carboxylic acid (17.5 mg, 0.06 mmol), diisopropylethylamine (10.32

I | ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol), shaken at room temperature overnight. The resin was then filtered off by succination and washed with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ . Then, to cleave the resin, 1.5 ml of 1: 1: 3 mixture of trifluoroethanol / acetic acid are added. acid / CH ₂ Cl ₂ and the mixture was again shaken to room ι

j temperature for 1 h. Evaporation of the cleavage solution of resin, the addition of 2 ml of acetic acid to the residue j and lyophilization give 8 mg of the desired product, ESI-MS j [M + H ⁺ ] = 483.

ι i j j Example 4

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] amino} acetyl) -3- (3-pyridinyl) -p-alanine (4)

I

0.03 mmol N-61y- [3- (3-pyridinyl) -p-alanine] trityl-resin was suspended in DMF and after addition of (2 {[(benzylamino) carbonyl] amino} -1,3-thiazole-4- yl) acetic acid (17.5 mg, 0.06 mmol), diisopropylethylamine (10.32 ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol) were shaken at room temperature! one night. The resin was then filtered off by succination and washed with dimethylformamide, CH ₂ Cl ₂ , CH ₃ OH and CH ₂ Cl ₂ . Then, for cleavage of the resin, 1.5 ml of 1: 1: 3 mixture of trifluoroethanol / acetic acid / CH ₂ Cl _{2 was added} and the mixture again

01/283/02 / PB

408 was shaken at room temperature for 1 h. Evaporation of the resin cleavage solution, addition of 2 ml of acetic acid to the residue and lyophilization gave 10 mg of the desired product, ESI-MS [M + H ⁺ ] = 497.

The following compounds are similarly prepared:

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} acetyl) -3- (3,5-dichlorophenyl) -p-alanine (5) mg ; ESI-MS [M + H +] = 550.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} acetyl) -3- (2-naphthyl) f-alanine (6) mg; ESI-MS [M + H +] = 532.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) -3- [biphenyl-4-yl] -p-alanine (7) mg ; ESI-MS [M + H +] = 560.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} acetyl) -3- (2,3-dimethoxyphenyl) -p-alanine (8) mg ; ESI-MS [M + H +] = 542.

N - ([[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} acetyl) -3- (1-naphthyl) -p-alanine (9) mg; ESI-MS [M + H +] = 532.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} acetyl) -3- (3,5-dichlorophenyl) -p-alanine (10) 42 mg; ESI-MS [M + H +] = 565.

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409

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} acetyl) -3- (2-naphthyl) -p-alanine (11) 44 mg; ESI-MS [M + H +] = 546.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} acetyl) -3- [biphenyl-4-yl] alanine (12) 7 mg; ESI-MS [M + H +] = 572.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} acetyl) -3- (2,3-dimethoxyphenyl) -p-alanine (13) 30 mg; ESI-MS [M + H +] = 556.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} acetyl) -3- (1-naphthyl) -p-alanine (14) 37 mg; ESI-MS [M + H +] = 546.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) -3- (3,5-dichlorophenyl) -p -alanine (15) 24 mg; ESI-MS [M + H +] = 579.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) -3- (3-pyridinyl) -p-alanine (16)

7.1 mg; ESI-MS [M + H +] = 511.

N - ((2S) -2 - ([(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) -3- (2-naphthyl) -p-alanine (17) 17 mg; ESI-MS [M + H +] = 560.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] amino} propanoyl) -3- [biphenyl-4-yl] -p alanine (18)

01/283/02 / PB 410 mg; ESI-MS [M + H +] = 586.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) -3- (2,3-dimethoxyphenyl) -p -alanine (19) mg; ESI-MS [M + H +] = 570.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) -3- (1-naphthyl) -p-alanine (20) mg; ESI-MS [M + H +] = 560.

N - ((2B) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) -3- (4-methylphenyl) -p-alanine (21) mg; ESI-MS [M + H +] = 524.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) -3- (3,5-dichlorophenyl) -p alanine (22)

18.5 mg; ESI-MS [M + H +] = 565.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) -3- (3-pyridinyl) -p-alanine (23)

4.8 mg; ESI-MS [M + H +] = 497.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino) propanoyl) -3- (2-naphthyl) -p-alanine (24)

18.4 mg; ESI-MS [M + H +] = 546.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) -3- [biphenyl-4-yl] -p -alanine (25) mg; ESI-MS [M + H +] = 572.

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411

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) -3- (2,3-dimethoxyphenyl) -p -alanine (26) mg; ESI-MS [M + H +] = 556.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) -3- (1-naphthyl) f-alanine ( 27) 13 mg; ESI-MS [M + H +] = 546.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) -3- (4-methylphenyl) -p-alanine (28) 18 mg; ESI-MS [M + H +] = 510.

N - ((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) -3- (4-methylphenyl) f-alanine ( 29) 17.2mg; ESI-MS [M + H +] = 510.

(2S) -3 - [((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) amino] -2 {[( benzyloxy) carbonyl] amino} propanoic acid (30)

11.1 mg; ESI-MS [M + H +] = 583.

(2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid (31)

14.9 mg; ESI-MS [M + H +] = 569.

(2S) -3 - [((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) amino] -2 {[( benzyloxy) carbonyl] amino} propanoic acid (32)

6.5 mg; ESI-MS [M + H +] = 569.

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412 (2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl ] amino} propanoic acid (33)

5.9 mg; ESI-MS [M + H +] = 555.

N - {[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] (methyl) amino] acetyl} -3- (3-pyridinyl) -p-alanine ( 34) mg; [M + H +] = 512.

N - {[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] (methyl) amino] acetyl) -3- (3,5-dichlorophenyl) -p- alanine (35) 18 mg; [M + H +] = 579.

(2R) -3 - ({[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] (methyl) amino] acetyl} amino-2 {[(benzyloxy) carbonyl] amino} propanoic acid (36) mg; [M + H +] = 583.

(2R) -3 - ({[(3 {[(Benzylamino) carbonyl] amino} benzoyl) amino] acetyl} amino) -2 {[(benzyloxy) carbonyl] amino} propanoic acid (37) mg; [M + H +] = 548.

(2R) -3 - ({(2S) -2 - [(3 - {[(

Benzylamino) carbonyl] amino) benzoyl) amino] propanoyl} amino) 2 - {[(benzyloxy) carbonyl] amino} propanoic acid (38) mg; [M + H +] = 562.

School

01/283/02 / PB 413

N - {[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] (methyl) amino] acetyl} -3- (3,5-dichlorophenyl) -p- alanine (39) mg; [M + H +] = 564.

N - {[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] (methyl) amino] acetyl} -3- (3-pyridinyl) f-alanine (40 ) 18 mg; [M + H +] = 497.

(2R) -3 - ({[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] (methyl) amino) -2 {[(benzyloxy) carbonyl] amino } propanoic acid (41) mg; [M + H +] = 569.

N - ((2R) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] amino} propanoyl) -3- (3-pyridinyl) -p -alanine (42) mg; ESI-MS [M + H +] = 511.

N - ((2R) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) acetyl] amino} propanoyl) -3- (3,5-dichlorophenyl) -p-alanine (43) 20 mg; ESI-MS [M + H +] = 579.

N - ((2R) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino) propanoyl) -3- (3,5-dichlorophenyl) -p-alanine (44) mg; ESI-MS [M + H +] = 565.

N - ((2R) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} propanoyl) -3- (3-pyridinyl) -p -alanine (45) mg; ESI-MS [M + H +] = 497.

01/283/02 / PB

414 (2S) -3 - [((2B) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) amino] -2 {[ (benzyloxy) carbonyl] amino} propanoic acid (46) mg; ESI-MS [M + H +] = 569.

(2S) -3 - [((2R) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) amino] -2 {[( benzyloxy) carbonyl] amino} propanoic acid (47) mg; ESI-MS [M + H +] = 583.

N - {[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] (methyl) amino] acetyl} -3-cyclohexyl-p-alanine (48) mg; ESI-MS [M + H +] = 502.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) -3-cyclohexyl-alanine (49) mg; ESI-MS [M + H ⁺ ] = 488.

1 \ 1 - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4-yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine (50 );

ESI-MS [M + H ⁺ ] = 483.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-4-yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine (51);

ESI-MS [M + H +] = 467.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-5-yl) carbonyl] amino} acetyl) -3- (2,5-dimethoxyphenyl) -beta-alanine (52 );

ESI-MS [M + H ⁺ ] = 542.

01/283/02 / PB

415

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-4-yl) carbonyl] amino} acetyl) -3- (2-naphthyl) -beta-alanine (53);

ESI-MS [M + H ⁺ ] = 516.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-4-yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -beta-alanine (54);

ESI-MS [M + H ⁺ ] = 480.

(2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-4-yl) carbonyl] amino) acetyl) -3-amino] -2 - {[( benzyloxy) carbonyl] amino} propanoic acid (55);

ESI-MS [M + H ⁺ ] = 539.

3- {1 - [({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] amino} acetyl) amino] -2-carboxyethyl} pyridinium acetate (56);

ESI-MS [M + H ⁺ ] = 479.

N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] amino} acetyl) -3- (2-naphthyl) -beta-alanine ( 57);

ESI-MS [M + H ⁺ ] = 528.

(2B) -3 - [({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid (58);

ESI-MS [M + H ⁺ ] = 551.

N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) -3- [biphenyl-4-yl] -beta-alanine ( 59);

ESI-MS [M + H ⁺ ] = 554.

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N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -beta-alanine (60) ; ESI-MS [M + H ⁺ ] = 492.

N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) -3-cyclohexyl-beta-alanine (61); ESI-MS [M + H ⁺ ] = 484.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] (methyl) amino] acetyl) -3-cyclohexyl-beta-alanine (62 ); ESI-MS [M + H ⁺ ] = 498.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] (methyl) amino] acetyl) -3- (3,4-dimethoxyphenyl) -betaalanine (63);

ESI-MS [M + H ⁺ ] = 552.

N- (3 - {[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] amino} propanoyl) -3-pyridin-3-yl-beta-alanine (64); ESI-MS [M + H ⁺ ] = 493.

N- (3 - {[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] amino} propanoyl) -3- (2,5-dimethoxyphenyl) - beta-alanine (65);

ESI-MS [M + H ⁺ ] = 552.

N - ((2R) -2 - {[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} propanoyl) -3- (4-tert-butylphenyl) ) -beta-alanine (66);

ESI-MS [M + H ⁺ ] = 548.

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417

N - ((2R) -2 - {[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} propanoyl) -3- (3,4-dimethoxyphenyl) -betaalanine (67);

ESI-MS [M + H ⁺ ] = 552.

(2S) -3 - [({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl] amino} -propanoic acid (68 );

ESI-MS [M + H ⁺ ] = 554.

N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) -3- (3,5-dichlorophenyl) -beta-alanine ( 69);

ESI-MS [M + H ⁺ ] = 546.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl)] -3-pyridin-3-yl-beta-alanine (70); ESI-MS [M + H ⁺ ] = 482.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl)] - 3- (3,5-dichlorophenyl) -beta-alanine (71);

ESI-MS [M + H ⁺ ] = 549.

N - (([[5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl)] - 3- (4-methylphenyl) -beta-alanine (72); ESI-MS [M + H *] = 495.

(28) -3 - [({[(5 - {[(Benzylamino) carbonyl] amino] thien-2yl) carbonyl] amino} acetyl)] - amino] -2 [(phenylsulfonyl) amino] propanoic acid (73);

mouse

01/283/02 / PB 418

ESI-MS [M + H ⁺ ] = 560.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl)] - 3- (4-tert-butylphenyl) -beta-alanine (74);

ESI-MS [M + H ⁺ ] = 537.

4 - [({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl)] - 3 {[(benzyloxy) carbonyl] amino} butanoic acid (75);

ESI-MS [M + H ⁺ ] = 568.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl)] -3-cyclohexyl-beta-alanine (76); ESI-MS [M + H ⁺ ] = 487.

N - {[[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] (methyl) amino] acetyl} -3- [biphenyl-4-yl] -beta-alanine (77);

ESI-MS [M + H ⁺ ] = 571.

N - {[[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] (methyl) amino] acetyl} -3- (2,5-dimethoxyphenyl) -betaalanine (78);

ESI-MS [M + H ⁺ ] = 555.

B1 - {[[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] (methyl) amino] acetyl} -3- (4-methylphenyl) -beta-alanine (79);

ESI-MS [M + H ⁺ ] = 509.

01/283/02 / PB 419 (28) -3 - ({[[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] (methyl) amino] acetyl} amino-2 {[(benzyloxy) carbonyl] amino} propanoic acid (80);

ESI-MS [M + H ⁺ ] = 568.

N - {[[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] (methyl) amino] acetyl} -3-cyclohexyl-beta-alanine (81);

ESI-MS [M + H ⁺ ] = 501.

N - {[[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] (methyl) amino] acetyl} -3- (3,4-dimethoxyphenyl) -betaalanine (82);

ESI-MS [M + H ⁺ ] = 555.

4 - ({[[(5 - {[(Benzylamino) carbonyl] amino} thien-2-yl) carbonyl] (methyl) amino] acetyl} amino) -3 {[(benzyloxy) carbonyl] amino} butanoic acid (83 ); ESI-MS [M + H ⁺ ] = 582.

N- (3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3-pyridin-3-yl-beta-alanine (84); ESI-MS [M + H ⁺ ] = 496.

N- (3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino] propanoyl} -3- (2,5-dimethoxyphenyl) -betaalanine (85);

ESI-MS [M + H ⁺ ] = 555.

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420 (2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid (86);

ESI-MS [M + H ⁺ ] = 568.

N- (3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3-cyclohexyl-beta-alanine (87); ESI-MS [M + H ⁺ ] = 501.

(2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl-2 [(phenylsulfonyl) amino] propanoic acid (88); ESI-MS [M + H ⁺ ] = 574.

I j

N-N- (3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2j yl) carbonyl] amino} propanoyl) -3- (4-tert-butylphenyl) -beta-alanine (89);

ESI-MS [M + H ⁺ ] = 551.

N- (3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3- (3,4-dimethoxyphenyl) -betaalanine (90);

ESI-MS [M + H ⁺ ] = 555.

N- (3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3- (3,4-dimethoxyphenyl) -betaalanine (91);

ESI-MS [M + H ⁺ ] = 582.

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421

N - ((2S) -2 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3- (4-tert-butylphenyl) -beta-alanine (92) ;

ESI-MS [M + H ⁺ ] = 551.

N - ((2S) -2 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3- (3,4-dimethoxyphenyl) -betaalanine (93);

ESI-MS [M + H ⁺ ] = 555.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl) -3- (2,5-dimethoxyphenyl) -beta-alanine (94);

ESI-MS [M + H ⁺ ] = 541.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl) -3- (1-naphthyl) -beta-alanine (95); ESI-MS [M + H ⁺ ] = 531.

N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) -3- (3,4-dimethoxyphenyl) -beta-alanine (96 );

ESI-MS [M + H ⁺ ] = 538.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} -3- (3,5-dichlorophenyl) -betaalanine ( 97);

ESI-MS [M + H ⁺ ] = 560.

01/283/02 / PB 422

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} -3-pyridin-3-yl-beta-alanine (98);

ESI-MS [M + H ⁺ ] = 493.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} -3- (2-naphthyl) -beta-alanine (99); ESI-MS [M + H ⁺ ] = 542.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} -3- [biphenyl-4-yl] -beta -alanine (100);

ESI-MS [M + H ⁺ ] = 568.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} -3- (2,5-dimethoxyphenyl) -betaalanine ( 101);

ESI-MS [M + H ⁺ ] = 552.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} -3- (1-naphthyl) -beta-alanine (102); ESI-MS [M + H ⁺ ] = 542.

N - {[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} -3- (4-methylphenyl) -beta-alanine (103);

ESI-MS [M + H ⁺ ] = 506.

(2S) -3 - ({[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} amino) -2 {[( benzyloxy) carbonyl] amino} propanoic acid (104);

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ESI-MS [M + H ⁺ ] = 565.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl) -3- (3,4-dimethoxyphenyl) -beta-alanine (105);

ESI-MS [M + H ⁺ ] = 541.

N - {[[(5 - {[(Benzylamino) carbonyl] amino) thien-2yl) carbonyl] (methyl) amino] acetyl} -3-pyridin-3-yl-beta-alanine (106);

ESI-MS [M + H ⁺ ] = 496.

N 3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3- (1-naphthyl) -beta-alanine (107); ESI-MS [M + H ⁺ ] = 545.

B1- (3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3- (4-methylphenyl) -beta-alanine (108);

ESI-MS [M + H ⁺ ] = 509.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-3yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine (109); ESI-MS [M + H ⁺ ] = 482.

N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-3yl) carbonyl] amino} acetyl) -3- (3,5-dichlorophenyl) -beta-alanine (110);

ESI-MS [M + H ⁺ ] = 549.

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N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-3yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -beta-alanine (111); ESI-MS [M + H ⁺ ] = 495.

(28) -3 - [({[(5 - {[(Benzylamino) carbonyl] amino} thien-3yl) carbonyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid (112) ;

ESI-MS [M + H ⁺ ] = 554.

N - ({[(2 - ([(Benzylamino) carbonyl] amino} -1,3-oxazol-5yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine (113);

ESI-MS [M + H ⁺ ] = 467.

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-5yl) carbonyl] amino} acetyl) -3- (3,5-dichlorophenyl) -beta-alanine (114);

ESI-MS [M + H ⁺ ] = 534.

(2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-5yl) carbonyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid (115);

ESI-MS [M + H ⁺ ] = 539.

N - ((2R) -2 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino) propanoyl) -3- (3,4-dimethoxyphenyl) -betaanine (116);

ESI-MS [M + H ⁺ ] = 555.

N - ((2R) -2 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) -3- (4-tert-butylphenyl) -beta-alanine (117) ;

ESI-MS [M + H ⁺ ] = 551.

425

01/283/02 / PB

Examples ESI-MS [M + H ⁺ ] Amount [mg] 118 (2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazole-4-) yl) acetyl] amino} acetyl) amino] -2- [(phenylsulfonyl) amino] propanoic acid 575 4 119 (25) -3 - [((25) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} - 1,3-thiazol-4-yl) acetyl] amino} propanoyl) amino] - 2 - [(phenylsulfonyl) amino] propanoic acid 589 7 120 (2S) -3 - [((2R) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) amino] - 2 - [(phenylsulfonyl) amino] propanoic acid 589 5 121 (2S) -3 - [(3 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] amino} propanoyl) amino] - 2 - [(phenylsulfonyl) amino] propanoic acid 589 2 122 (2S) -3 - ({[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) acetyl] (methyl) amino] acetyl} amino) 2 - [(phenylsulfonyl) amino] propanoic acid 589 3 123 (2B) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazole- 4-yl) carbonyl] amino) acetyl) amino] -2 - [(phenylsulfonyl) amino] propanoic acid 561 6 124 (2S) -3 - [((2S) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) amino] - 2 - [(phenylsulfonyl) amino] propanoic acid 575 6 125 (2S) -3 - [((2R) -2 - {[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] amino} propanoyl) amino] - 2 - [(phenylsulfonyl) amino] propanoic acid 575 8 126 (28) -3 - [(3 - {[(2 - {[(benzylamino) carbonyl] amino} -1 ₁ 3-thiazol-4-yl) carbonyl] amino} propanoyl) amino] - 2 - [(phenylsulfonyl) amino] propanoic acid 575 4 127 (2S) -3 - ({[[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-4yl) carbonyl] (methyl) amino] acetyl} amino) -2- [(phenylsulfonyl) amino] propanoic acid 575 9 128 (2S) -3 - ({[[(5 - {[(Benzylamino) carbonyl] amino} thien-2-yl) carbonyl] (methyl) amino] acetyl} amino) - 2 - [(phenylsulfonyl) amino] propanoic acid 574 2 129 (28) -3 - [({[(5 - {[(Benzylamino) carbonyl] amino} thiene- 3-yl) carbonyl] amino} acetyl) -amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid 554 1 130 (2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino) -4-methyl-1,3-thiazole-5- 569 1

MN

426

01/283/02 / PB

Examples ESI-MS [M + H ⁺ ] Amount [mg] yl) carbonyl] amino} acetyl) amino] -2 - {[(benzyloxy) carbonyl] amino} propanoic acid 131 (2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino) -4-methyl-1,3-thiazol-5yl) carbonyl] amino} acetyl) amino] -2- [(phenylsulfonyl) amino] propanoic acid 575 2 132 (28) -3 - [({[(5 - {[(Benzylamino) carbonyl] amino} thien-3-) yl) carbonyl] amino} acetyl) amino] -2- [(phenylsulfonyl) amino] propanoic acid 560 1 133 (2B) -3 - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-3- yl) carbonyl] (methyl) amino] acetyl} amino) - 2 - [(phenylsulfonyl) amino] propanoic acid 574 16 134 (2c) -3 - ({[[(5 - {[(Benzylamino) carbonyl] amino) thien-3yl) carbonyl] (methyl) amino] acetyl} amino) -2 {[(benzyloxy) carbonyl] amino} propanoic acid 568 8 135 (2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien3-yl) carbonyl] amino} propanoyl) amino] -2 - {[(benzyloxy) carbonyl] amino} propanoic acid 568 6 136 (2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-3yl) carbonyl] amino} propanoyl) amino] 2 - [(phenylsulfonyl) amino] propanoic acid 574 2 137 (2S) -3 - ({[[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazol-3yl) carbonyl] (methyl) amino] acetyl} amino) 2- [ (phenylsulfonyl) amino] propanoic acid 559 2 138 (2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazole-3-) yl) carbonyl] amino} propanoyl) amino- 2 - [(phenylsulfonyl) amino] propanoic acid 559 6 139 (2S) -3 - [({[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazol-3yl) carbonyl] amino} acetyl) amino] -2- {[(Benzyloxy) carbonyl] amino} propanoic acid 539 7 140 (2S) -3 - ({[[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazol-3yl) carbonyl] (methyl) amino] acetyl} amino] -2- {[(Benzyloxy) carbonyl] amino} propanoic acid 553 2 141 (2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazole-3 - yl) carbonyl] amino} propanoyl) amino] -2- {[(Benzyloxy) carbonyl] amino} propanoic acid 553 9 142 (2S) -3 - ({{((5 - {[(Benzylamino) carbonyl] amino) -2-furoyl) amino] acetyl} amino) -2 - {[(benzyloxy) carbonyl] amino} propanoic acid 538 14

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Examples ESI-MS [M + H ⁺ ] Amount [mg] acid 143 (2S) -3 - ({[(5 - {[(Benzylamino) carbonyl] amino} -2-furoyl) (methyl) amino] acetyl} amino) -2 - {[(benzyloxy) carbonyl] amino} propanoic acid 552 8 144 (2S) -3 - ({3 - [(5 - {[(Benzylamino) carbonyl] amino} - 2-furoyl) amino] propanoyl} amino) -2 - {[(benzyloxy) carbonyl] amino} propanoic acid 552 17 145 (2S) -3 - ({3 - [(5 - {[(Benzylamino) carbonyl] amino} - 2-furoyl) amino] propanoyl} amino) -2 [(phenylsulfonyl) amino] propanoic acid 558 4 146 (2S) -3 - [((2c) -2 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-3-yl) carbonyl] amino} -3-methylbutanoyl) amino] -2- {[Benzyloxy) carbonyl] amino} propanoic acid 596 16 147 (23) -3 - [({[(5 - {[(Benzylamino) carbonyl] amino} -1,3-thiazole-2- yl) carbonyl] amino} acetyl) amino] - 2 - {[(Benzyloxy) carbonyl] amino} propanoic acid 555 6 148 (3R) -4 - ({[[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] (methyl) amino] acetyl} amino) -3 {[(benzyloxy) ) carbonyl] amino} butanoic acid 579 6 149 (3S) -4 - [(3 - {[4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrole- 2-yl) carbonyl] amino} propanoyl) amino] - 3- {[(benzyloxy) carbonyl] amino} butanoic acid 579 2 150 (3R) -4 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} propanoyl) amino-3 - {[(benzyloxy) carbonyl] amino) butanoic acid 582 18 151 (3R) -4 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazole-4-) yl) carbonyl] amino} acetyl) amino] - 3 - {[(Benzyloxy) carbonyl] amino} butanoic acid 569 9 152 (3R) -4 - [({[(5 - {[(Benzylamino) carbonyl] amino} thien-3-) yl) carbonyl] amino} acetyl) amino] - 3 - {[(Benzyloxy) carbonyl] amino} butanoic acid 568 8 153 (3R) -4 - (([[((5 - {[(Benzylamino) carbonyl] amino} thien-3-yl) carbonyl] (methyl) amino] acetyl} amino) -3 - {[(benzyloxy) carbonyl] amino } Butanoic acid 582 1 154 (3R) -4 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien- 3-yl) carbonyl] amino} propanoyl) amino] -3- {[(Benzyloxy) carbonyl] amino} butanoic acid 582 14

01/283/02 / PB 428

Examples ESI-MS [M + H ⁺ ] Amount [mg] 155 (3R) -4 - [({[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazol-3yl) carbonyl] amino} acetyl) amino] -3- {[(Benzyloxy) carbonyl) amino} butanoic acid 553 19 156 (3R) -4 - ({[[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazole-3- yl) carbonyl] (methyl) amino] acetyl} amino) -3- {[(Benzyloxy) carbonyl] amino} butanoic acid 567 22 157 (3R) -4 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} -1H-1,2,4-triazol-3yl) carbonyl] amino} propanoyl) amino] 3 - {[ (benzyloxy) carbonyl] amino} butanoic acid 567 22 158 (3R) -4 - ({[(5 - {[(Benzylamino) carbonyl] amino} -2-furoylamino] acetyl} amino) -3 - {[(benzyloxy) carbonyl] amino} butanoic acid 552 2 159 (3R) -4 - ({[(5 - {[(Benzylamino) carbonyl] amino} -2-furoyl) (methyl) amino] acetyl} amino) -3 - {[(benzyloxy) carbonyl] amino} butanoic acid 566 2 160 (3R) -4 - ({3 - [(5 - {[(Benzylamino) carbonyl] amino} -2-furoyl) amino] propanoyl} amino) - 3 - {[(Benzyloxy) carbonyl] amino} butanoic acid 566 23 161 (3R) -4 - [({[(5 - {[(Benzylamino) carbonyl] amino} -1,3-thiazol-2-yl) carbonyl] amino and acetyl) -3-methyl] -3 {[(Benzyloxy) carbonyl] amino} butanoic acid 569 16

Synthesis

The N substituents at position a of the carboxylic acid can vary widely following the reaction sequence:

α-M-Gtos-β-N-Al-diaminopropanoic acid (4.52 g) was coupled as described by P. Sieber (Tetrahedron Lett. 28 (1987) 6147) with 5 g of Wang resin. The Fmoc group was then cleaved using a 20 ml mixture of 10% DBU, 2% piperidine and 88% DMF for 3 min. The resin was filtered off by succination, washed several times with DMF, CH ₂ Cl ₂ and diethyl ether and dried. As a result, 1.15 mmol / g are charged.

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429

At position a, acyl radicals were introduced by the addition of 3 eq carboxylic acid and activated with HATU or TBTU by the usual standard process within 4 h. Sulfonyl radicals were introduced by suspending 0.145 g of the charged resin in 1 ml of CH ₂ Cl ₂ and adding a solution of 0.4 eq DMAP, 4 eq methoxy (trimethylsilyloxy) dimethyl ketal acetal (MTDA) and 2 eq sulfonyl chloride in 1.5 ml CH ₂ CI ₂ (see M. Gude et al., Tetrahedron Lett. 37 (1996) 8589). After 8 h, the resin was filtered off by succinate and washed 10x with CH ₂ Cl ₂ , 5x with DMF and 5x with CH ₂ Cl ₂ .

The Aloe group is cleaved by washing the polymer with N ₂ and adding a solution of 24 eq phenylsilane in oxygen free CH ₂ Cl ₂ (see N. Thieriet et al., Tetrahedron Lett. 38 (1997) 7275). 0.1 eq Pd (PPh ₃ ) ₄ dissolved in CH ₂ Cl _{2 was added} and the mixture was reacted for about 90 min.

The 3 eq Fmoc-amino acid in DMF was then activated with TBTU by the usual standard procedures and coupled to the free amino group within 8 h. The Fmoc protecting group cleaves as described above.

The final coupling with M- (3-carboxythien-5-yl) N'-benzylurea was carried out analogously to the coupling above within 2 d.

The resin was carefully washed with DMF and CH ₂ Cl ₂ and then 1.5 ml of 95% TFA and 5% water were added. After 45 min, the resin was filtered off and washed with a little CH ₂ Cl ₂ . The filtrate was combined and concentrated. The residue may be purified by one or more of the following methods for testing purposes:

01/283/02 / PB

430

1. Dissolve in a little methanol and precipitate by adding water. It is filtered off by suction and dried.

2. The residue was dissolved in ethyl acetate, and the solution was extracted with water. This is followed by concentration and stirring with diethyl ether. The precipitate was filtered off by suction and dried.

3. The residue is chromatographed on a silica gel column.

Examples ESI-MS [M + H ⁺ ] Amo unt [mg] 162 (28) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thieno- 3-yl) carbonyl] amino} propanoyl) amino] -2 - {[(2-chlorophenyl) sulfonyl] amino} propanoic acid 608.15 and 610.15 9.1 163 (2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien3-yl) carbonyl] amino} propanoyl) amino] -2 [(butylsulfonyl) amino] propanoic acid 554.15 1.8 164 (28) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thieno- 3-yl) carbonyl] amino} propanoyl) amino] -2 [(benzylsulfonyl) amino] propanoic acid 588.15 21.2 165 (28) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thieno- 3-yl) carbonyl] amino} propanoyl) amino] -2 [(1-naphthylsulfonyl) amino] propanoic acid 624.15 16.3 166 (28) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thieno- 3-yl) carbonyl] amino} propanoyl) amino] -2 [(2-Naphthylsulfonyl) amino] propanoic acid 624.15 19.2 167 (28) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thieno- 3-yl) carbonyl] amino} propanoyl) amino] -2 - {[(2,4,5trichlorophenyl) sulfonyl) amino} propanoic acid 676.05; 677.95; 680.0; 682.0 6.5 168 (2S) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thien3-yl) carbonyl] amino} propanoyl) amino] -2 - {[(2,6-dichlorophenyl) sulfonyl] amino] propanoic acid 642.15; 644.05 13.1 169 (28) -3 - [(3 - {[(5 - {[(Benzylamino) carbonyl] amino} thieno- 3-yl) carbonyl] amino} propanoyl) amino] -2 {[(2,5-dimethoxyphenyl) sulfonyl] amino} propanoic acid 634.15 3.3

01/283/02 / PB 431

II. Biological examples

Example 1

Study for α _ν β ₃

Integrin α _ν β ₃ antagonists were identified and investigated using a test system based on competition between native α _ν β ₃ ligand vitronectin and the test substance for binding to integrin α _ν β ₃ attached to the solid phase.

Procedure for coating microtiter plates with 250 ng / ml integrin-oc $ ₃ in 0.05 M NaHCO ₃ pH 9.2; 0.1 ml / well;

saturation with 1% milk powder buffer for testing; 0.3 ml / per well; 0.5 h / RT wash 3x with 0.05% Tween 20 / test buffer test substance in 0.1% milk powder test buffer, 50 μΙ / well + 0 pg / ml or 2 pg / ml human vitronectin (Boehringer Ingelheim T007) in 0.1% milk assay buffer, 50 pl / well; 1 h / RT washing 3x with 0.05% Tween 20 / assay buffer pg / ml anti-human vitronectin antibody coupled to peroxidase (Kordia SAVN-APHRP) in 0.1% milk powder assay buffer; 0.1 ml / well; 1 hr / RT

01/283/02 / PB

432 wash 3x with 0.05% Tween 20 / assay buffer

0.1 ml / well peroxidase substrate stopping the reaction with 0.1 ml / well 2 M H ₂ SO ₄ absorbance measurement at 450 nm

Integrin α _ν β ₃ : human placenta solubilizes with Nonidet, and integrin α _ν β ₃ is purified from the antibody on the GRGDSPK matrix (elution with EDTA). Contamination by integrin _IIb beta ₃ and human serum albumin, as well as the detergent and EDTA, are removed by anion exchange chromatography.

Assay buffer: 50 mM Tris pH 7.5; 100 mM NaCl; 1 mM CaCl ₂ ; 1 mM MgCl ₂ ; 10 μΜ MnCI ₂ Peroxidase substrate: mixing 0.1 ml of TMB solution (42 mM TMB in DMSO) and 10 ml of substrate buffer (0.1 M Na acetate pH 4.9) and then adding 14.7 μΙ of 3% H ₂ O ₂ .

Different dilutions of the test substance were used in the study, and IC ₅₀ values were determined (concentration of antagonist at which 50% of the ligand was displaced). The following table shows the IC ₅₀ values of the selected examples.

Compound IC 50 DEG [μΜ] N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-thiazole-5- yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine 10

01/283/02 / PB

433

N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazole-4-) yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine 0.0138 N - ({[(2 - {[(Benzylamino) carbonyl] amino) -1,3-oxazole-4- yl) carbonyl] amino} acetyl) -3- (2-naphthyl) -beta-alanine 0.048 N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazole-4-) yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -beta-alanine 0.040 (2S) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-4yl) carbonyl] amino) acetyl) amino] -2 - {[(benzyloxy) carbonyl] amino } propanoic acid 0.1 3- {1 - [({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] amino} acetyl) amino] -2carboxyethyl} pyridinium acetate 0.016 N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) -3- (2-naphthyl) -beta-alanine 0.043 (2S) -3 - [({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2-yl) carbonyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid 0.26 N - ({[(4 - {[(Benzylamino) carbonyl] amino} -1-methyl-1H-pyrrol-2yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -beta-alanine 0.039 N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2-yl) carbonyl] - amino} acetyl) -3-pyridin-3-yl-beta-alanine 1 N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2yl) carbonyl] amino} acetyl) -3- (3,5-dichlorophenyl) -betaalanine 10 N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-2-) yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -beta-alanine 10 N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-3-) yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine 0.0005 N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-3yl) carbonyl] amino} acetyl) -3- (3,5-dichlorophenyl) -betaalanine 0.0047 N - ({[(5 - {[(Benzylamino) carbonyl] amino} thien-3- yl) carbonyl] amino} acetyl) -3- (4-methylphenyl) -beta-alanine 0.0021

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434

(2S) -3 - [({[(5 Benzylamino) carbonyl] amino} thien-3yl) carbonyl] amino} acetyl) amino] -2 {[(benzyloxy) carbonyl] amino} propanoic acid 0.0118 N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazole-5- yl) carbonyl] amino} acetyl) -3-pyridin-3-yl-beta-alanine 0.00028 N - ({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-5yl) carbonyl] amino} acetyl) -3- (3,5-dichlorophenyl) -betaalanine 0.00038 (25) -3 - [({[(2 - {[(Benzylamino) carbonyl] amino} -1,3-oxazol-5yl) carbonyl] amino} acetyl) amino] -2 - {[(benzyloxy) carbonyl] amino } propanoic acid 0.0018

Example 2

Assay for ac _b p ₃

The study is based on competition between the natural integrin _IIb beta ₃ ligand fibrinogen and the test substance for binding to integrin _IIb RD ·

Procedure:

- microtiter plates are coated with 10 pg / ml fibrinogen (Calbiochem 341578) in 0.05 M NaHCO ₃ pH 9.2; 0.1 ml / well;

- saturation with 1% BSA / PBS; 0.3 ml / per well; 30 min / RT

- washing 3x with 0.05% Tween 20 / PBS

01/283/02 / PB 435

- substance testing in 0.1% BSA / PBS; 50 μΙ / well + 200 pg / ml integrin acet _b p ₃ (Kordia) and 0.1% BSA / PBS; 50 μΙ / well; 2-4 hrs / RT!

- washing 3x as above j - biotinylated anti-integrin α ^ β ₃ antibodies (Dianova CBL

130 B), 1: 1000 in 0.1% BSA / PBS; 0.1 ml / well; 2-4 hrs / RT ί

j

I j - flushing 3x as crazy j

- streptavidin peroxidase complex (B.Μ. 1089153) 1: 10000 in 0.1% BSA / PBS; 0.1 t1 / well1; 30 min / RT

- Wash 3x as above

- 0.1 ml / well peroxidase substrate

I | - quenching the reaction with 0.1 ml / well 2 M H ₂ SO ₄

absorbance measurement at 450 nm Peroxidase substrate: mixing 0.1 ml TMB solution (42 mM f

TMB in DMSO) and 10 ml of substrate buffer (0.1 M Na acetate pH j 4.9), then adding 14.7 pl of 3% H ₂ O ₂ f

I

Different dilutions of the test substance are used in the assay, and IC ₅₀ values are determined (concentration of antagonist at which 50% of the ligand is displaced).

01/283/02 / PB

436

The selectivity of the substances can be determined by comparing the IC ₅₀ values in the integrin αβP3 and the integrin α _ν β ₃ samples.

Example 3

SAM test

SAM (chorioallantoic membrane) assay is the most widely accepted model for studying the in vivo activity of integrin α ₇ γ antagonists. It is based on the inhibition of angiogenesis and neovascularization of tumor tissue (Am. J. Pathol. 1975, 79, 597-618; Cancer Res. 1980, 40, 2300-2309; Nature 1987, 329, 630). The procedure is similar to that of the prior art. The development of chicken embryonic blood samples and transplanted tumor tissue can be monitored and investigated.

Example 4

Rabbit eye test

Inhibition of angiogenesis and neovascularization in the presence of integrin α _ν β ₃ antagonists can be monitored and tested in this in vivo model by analogy to Example

3. The model is widely accepted and is based on the development of blood samples starting from the edge of the rabbit eye root (Proc. Natl. Acad. Sci. USA 1994, 91, 4082-4085; Science 1976, 193, 70-72 ). The procedure is similar to that of the prior art.

Claims (28)

Claims: A compound of formula I A-E-G-L where A, E, G and L have the following meanings: L is a structural element of the formula l _L , II where is a COOH group or a radical that is hydrolyzed to COOH may be R ² is hydrogen, NHSO ₂ R ²¹ , NHCOR ^{21 or} NHCOOR ²² , where R ²¹ is branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C ₃ -C ₆ -cycloalkyl, C ₁ -C ₄ 01/283/02 / PB 438 alkyl-C ₃ -C ₆ -cycloalkyl radical, C ₅ -C ₁₂ bececloalkyl or C ₆ -C ₁₈ -tricycloalkyl radical, one to three substituted, with identical or different radicals, aryl, alkylaryl, hetarylalkyl or 3- to A 6-membered, saturated, unsaturated or aromatic heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, for two radicals being fused together, saturated, unsaturated or aromatic carbocycles or heterocycles which may contain up to three different or identical heteroatoms Ο, N, S, and this nucleus may be optionally substituted, or another, optionally, saturated, unsaturated, or aromatic nucleus may be fused to that nucleus, j R ²² branched or unbranched, optionally substituted C ί _d C ₆ -alkyl rad mud or an optionally substituted aryl or an alkylaryl radical, j R ³ is hydrogen or- (CH _{2) b} - (X) _c -R ³¹ wherein b is 0, 1,2 or 3, c is 0 or 1, X is -SO ₂ -, -S-, -Ο-, -CO-, -NH-SO ₂ -, -Ο-CO-, -CO-Ο-, -NHCO-, -CO-NH-, -CO -N (R ³¹ ) -, -N (R ³¹ ) -CO-, -SO2-NH-, SO2-N (R ³¹ ) -or-N (R ³¹ ) -SO2-, I ί 01/283/02 / PB 439 R ³¹ is hydrogen, a hydroxyl group, branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C ₂ -C ₄ -alkoxy, -O-alkylaryl or -O-aryl radical, amino radical with a primary or optional secondary or tertiary substitution, optionally C 1 -C ₆ -alkyl or aryl-substituted C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -alkenyl radical, C ₅ -C ₁₂ bicycloalkyl, C ₆ -C ₁₈ -tricycloalkyl radical or 3- to 6-membered, saturated or an unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms Ο, N, S, C ₃ -C ₈ cycloalkyl, aryl or hetaryl radical, two of which may be fused, saturated, unsaturated or aromatic carbocycle or heterocycle containing up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted, or another optionally substituted, saturated, unsaturated, or aromatic nucleus may be fused to that nucleus, and R ⁴ is hydrogen, or branched or unbranched, optionally substituted C 1-4 -alkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ -alkynyl or C ₃ -C ₆ -cycloalkyl radical, G is a structural element of the formula l _G , 01/283/02 / PB 440 where d is 0, 1 or 2, R ⁵ is hydrogen, a hydroxyl group, branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C ₂ -C ₄ -alkoxy, -O-alkylaryl or -O-aryl radical, an amino radical with a primary or optional secondary or tertiary substitution, optionally C 1-6 -alkyl or aryl-substituted C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -alkenyl radical, C ₅ -C ₁₂ bicycloalkyl, C ₆ -C ₁₈ -tricycloalkyl radical or 3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain three different or identical heteroatoms Ο, N , S, C ₃ -C ₈ cycloalkyl, aryl or hetaryl radical, two of which may be fused, saturated, unsaturated or aromatic carbocycle or heterocycle containing up to three different or identical heteroatoms ма, N, S, and the nucleus may be optionally substituted, or may be fused to this nucleus by another optionally substituted, saturated, unsaturated or aromatic nucleus, or side chain of a natural amino acid, 01/283/02 / PB 441 R ⁶ is hydrogen, or branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ -alkynyl or C ₃ -C ₆ -cycloalkyl radical, E is a structural element of the formula 1 _E - (NH) _g - (CH ₂ ) _r Q- (CH ₂ ) _e -CO- 1 _E where is 0,1 or 2, f is 0 or 1, g is 0 or 1, Q is a double bonded, optionally substituted hetaryl radical, for which two of the substituents together may be a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms Ο, N, S, and this nucleus may optionally be replaced, or fused, optionally substituted, saturated, unsaturated or aromatic to be fused to this nucleus, And one of the structural elements of the formula I _A ¹ to I _A ²⁰ , 01/283/02 / PB 442 where R ^10, R ¹¹ are, independently of one another, hydrogen, - (CH ₂ ) _h - (Y) iR ¹⁰¹ , or the two radicals together are 3- to 8-membered, optionally substituted, saturated, unsaturated or aromatic N-heterocycle , which may further comprise two other identical or different heteroatoms Ο, N or S, 01/283/02 / PB 443 where h is 0, 1, 2 or 3, i is 0 or 1, Y is -SO ₂ -, -S-, -Ο-, -CO-, -NH-SO ₂ -, -Ο-CO-, -CO-Ο-, -NHCO-, -CO-NH-, -CO -N (R ¹⁰¹ ) -, -N (R ¹⁰¹ ) -CO-, -SO2-NH-, N (R ¹⁰¹ ) -SO2- or -SO ₂ -N (R ¹⁰¹ ) - and R ¹⁰¹ hydroxyl group, branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C ₁ -C ₄ alkoxy, -O-alkylaryl or -O-aryl radical, amino radical with a primary or optional secondary or tertiary substitution, optionally C 1 -C 6 - alkyl or aryl-substituted C ₂ -C ₆ -alkynyl or C ₂ -C ₆ -alkenyl radical, C ₅ -C ₁₂ -bicycloalkyl, C ₆ -C ₆ -cycloalkyl radical or 3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms Ο, N, S, C ₃ -C ₈ -cycloalkyl, aryl or hetaryl radical, with two of the radicals possibly being fused, saturated, unsaturated or aromatic carbocycle or heterocycle containing up to three different or identical heteroatoms Ο, N, S, and the nucleus may be optionally substituted, or to merge another optionally substituted, saturated, unsaturated or aromatic nucleus, 01/283/02 / PB 444 R ¹² is a branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl, alkylaryl, C ₃ -C ₆ -cycloalkyl or C ₁ -C ₄ alkyl-C ₃ -C ₆ -cycloalkyl radical, or an optionally substituted aryl radical, R ¹³ is hydrogen, -OH, -CN, -CONH ₂ , branched or unbranched, optionally substituted C 1 -C ₄ -alkyl, C ₂ -C ₄ -alkoxy or -O-CO-C ₂ -C ₄ -alkyl radical, or an optionally substituted alkylaryl, -O-alkylaryl, -O-CO-aryl, O-CO-alkylaryl or -O-CO-allyl radical, R ¹⁴ is hydrogen, branched or unbranched, optionally substituted C ₂ -C ₄ -alkyl, -CO-O-C ₁ -C ₄ -alkyl, alkylaryl, -CO-O-alkylaryl, -CO-O-allyl, -CO 2 _g C ₄ - alkyl, -CO-alkylaryl or -CO-allyl radical, R ¹⁵ is hydrogen, branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl radical or optionally substituted aryl or alkylaryl radical, R ¹⁶ , R ¹⁷ are, independently of each other, -NH ₂ halogen or branched or unbranched, optionally substituted C ₁ -C ₄ -alkyl or C ₂ -C ₄ -alkoxy radical or optionally substituted aryl radical, Ζ ¹ , Ζ ² , Ζ ³ , Z ⁴ are, independently of one another, CH, C-CH ₃ , C-OCH ₃ , C-CI or N, 01/283/02 / PB 445 and physiologically tolerated salts, drug precursors, and enantiomerically pure or diastereomerically pure and tautomeric forms. A pharmaceutical preparation for oral or parenteral administration comprising at least one compound according to claim 1 in addition to conventional pharmaceutical excipients. Use of a compound according to claim 1 for the preparation of medicaments for the treatment of diseases. Use according to claim 3 of a compound of claim 1 as an integrin receptor antagonist. Use according to claim 4 of a compound of claim 1 as an α _ν β3 integrin receptor antagonist. Use of a compound of claim 1 for the preparation of medicaments for the treatment of diseases involving an integrin receptor. Use according to claim 6 of a compound of claim 1 for the treatment of diseases involving the α _ν β3 integrin receptor. Use according to claim 7 of a compound according to claim 1 for the treatment of atherosclerosis, rheumatoid arthritis, restenosis after vascular injury, angioplasty, acute kidney disease related to angiogenesis microangiopathies, diabetic angiopathies mediated by 01/283/02 / PB 446 platelets vascular occlusion, arterial thrombosis, congestive heart damage, myocardial infarction, stroke, cancer, osteoporosis, high blood pressure, psoriasis or viral, parasitic or bacterial diseases, wound healing, hyperparathyroidism, hyperparathyroidism, hyperparathyroidism osteolytic lesions. A pharmaceutical composition comprising at least one compound according to claim 1, wherein the suitable pharmaceutical excipients and at least one other compound selected from the group of platelet adhesion, activation or aggregation inhibitors, anticoagulants that prevent thrombin activity or formation, antagonists of platelet-activating compounds or selectin antagonists. Use of the pharmaceutical preparation according to claim 9 for the preparation of a medicament for the treatment of platelet-mediated vascular occlusion or thrombosis. A pharmaceutical composition comprising at least one compound according to claim 1, wherein suitable pharmaceutical excipients and at least one other compound are selected from the group of: platelet activation or aggregation inhibitors, serine protease inhibitors, fibrinogen-reducing compounds, selectin antagonists, ICAM-1 or VCAM-1 antagonists, 01/283/02 / PB 447 leukocyte adhesion inhibitors, inhibitors of transmigration through vascular walls modulating fibrinolysis compounds, inhibitors of complement factors, endothelin receptor antagonists, tyrosine kinase inhibitors, antioxidants or interleukin antagonists 8. Use of a pharmaceutical preparation according to claim 11 for the preparation of a medicament for the treatment of myocardial infarction or stroke. A pharmaceutical composition comprising at least one compound according to claim 1, wherein suitable pharmaceutical excipients and at least one other compound are selected from the group of: endothelin antagonists, ACE inhibitors, angiotensin receptor antagonists, endopeptidase inhibitors, beta blockers, calcium channel blockers, phosphodiesterase inhibitors or capsase inhibitors. The use of a pharmaceutical preparation according to claim 13 for the preparation of medicaments for the treatment of congestive heart disease. 01/283/02 / PB 448 A pharmaceutical composition comprising at least one compound according to claim 1, wherein the suitable pharmaceutical excipients and at least one other compound are selected from the group of: thrombin inhibitors, factor Xa inhibitors, inhibitors of the coagulation pathway leading to thrombin formation, platelet adhesion inhibitors, activation or aggregation, endothelin receptor antagonists, nitric oxide synthase antagonists, CD44 inhibitors, CD44 MCP-1 antagonists, inhibitors of signal transduction in proliferating cells, EGF, PDGF, VEGF or bFGF mediated cellular response antagonists, or antioxidants. Use of a pharmaceutical preparation according to claim 15 for the preparation of a medicament for the treatment of restenosis following vascular injury or stent implantation. A pharmaceutical composition comprising at least one compound according to claim 1, wherein suitable pharmaceutical excipients and at least one other compound are selected from the group of: 01/283/02 / PB 449 EGF, PDGF, VEGF or bFGF mediated cellular response antagonists, heparin or low molecular weight heparins or other GAGs, MMP inhibitors, selectin antagonists, endothelin antagonists, ACE inhibitors, angiotensin receptor antagonists, glycosylation inhibitors or inhibitors of AGE formation or antagonists of their receptors. Use of the pharmaceutical preparation according to claim 17 for the preparation of a medicament for the treatment of diabetic angiopathies. A pharmaceutical composition comprising at least one compound according to claim 1, wherein the suitable pharmaceutical excipients and at least one other compound are selected from the group of: lipid-lowering compounds, selectin antagonists, ICAM-1 or VCAM-1 antagonists, low molecular weight heparin or heparin, or other GAGs, MMP inhibitors, endothelin antagonists, apoliprotein A1 antagonists, cholesterol antagonists, cholesterol antagonists, cholesterol antagonists 01/283/02 / PB 450 ACAT inhibitors, ACE inhibitors, angiotensin receptor antagonists, tyrosine kinase inhibitors, tyrosine kinase C inhibitors, calcium channel blockers, LDL receptor stimulants, antioxidants or free radical scavengers. Use of a pharmaceutical preparation according to claim 19 for the preparation of a medicament for the treatment of atherosclerosis. 21. A pharmaceutical composition comprising at least one compound according to claim 1, wherein suitable pharmaceutical excipients and at least one other compound are selected from the group of: cytostatic or antineoplastic compounds, compounds that inhibit proliferation or heparin or low molecular weight heparins or other GAGn. Use of a pharmaceutical preparation according to claim 21 for the preparation of a medicament for the treatment of cancer. A pharmaceutical composition comprising at least one compound according to claim 1, wherein suitable pharmaceutical excipients and at least one other compound are selected from the group of: anti-resorptive therapy compounds, hormone replacement therapy compounds, 451 01/283/02 / PB recombinant human growth hormone, bisphosphonates, calcitonin therapy compounds, calcitonin stimulants, calcium channel blockers, bone stimulating stimulants, interleukin-6 antagonists or Src tyrosine kinases. Use of a pharmaceutical preparation according to claim 23 for the preparation of a medicament for the treatment of osteoporosis. A pharmaceutical composition comprising at least one compound according to claim 1, wherein suitable pharmaceutical excipients and at least one other compound are selected from the group of: TNF antagonists, VLA-4 or VCAM-1 antagonists, LFA-1, Mas-1 or 1AMAM antagonists, complement inhibitors, immunosuppressants, interleukin-1, -5, or -8 dihydrofolate reductase inhibitors. The use of a pharmaceutical preparation according to claim 25 for the preparation of a medicament for the treatment of rheumatoid arthritis. A pharmaceutical composition comprising at least one compound of claim 1, where appropriate 01/283/02 / PB 452 pharmaceutical excipients and at least one other compound are selected from the group of: collagenase, PDGF antagonists MMRI. Use of a pharmaceutical preparation according to claim 27 for the preparation of a medicament for improving wound healing.