AU4551500A - Integrin receptor antagonists - Google Patents

Integrin receptor antagonists Download PDF

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AU4551500A
AU4551500A AU45515/00A AU4551500A AU4551500A AU 4551500 A AU4551500 A AU 4551500A AU 45515/00 A AU45515/00 A AU 45515/00A AU 4551500 A AU4551500 A AU 4551500A AU 4551500 A AU4551500 A AU 4551500A
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gly
bala
bhs
phhs
tolhs
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Herve Geneste
Claudia Isabella Graef
Wilfried Hornberger
Andreas Kling
Udo Lange
Arnulf Lauterbach
Thomas Subkowski
Johann-Christian Zechel
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BASF SE
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BASF SE
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Priority claimed from DE1999119218 external-priority patent/DE19919218A1/en
Priority claimed from DE1999148269 external-priority patent/DE19948269A1/en
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    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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Description

WO 00/66618 PCT/EPOO/03469 Integrin receptor antagonists The invention relates to novel compounds which bind to integrin receptors, their preparation and use. 5 Integrins are cell surface glycoprotein receptors which mediate interactions between cells of the same type and different cells, and between cells and extracellular matrix proteins. They are involved in physiological processes such as, for example, embryogenesis, hemostasis, wound healing, immune response and formation/ maintenance of the tissue architecture. D Disturbances of the expression of cell adhesion molecule genes, and disturbances of receptor function may contribute to the pathogenesis of a large number of disorders such as, for example, tumors, thromboembolic events, cardiovascular disorders, pulmonary diseases, disorders of the CNS, of the kidney, of the gastrointestinal tract or inflammations. Integrins are heterodimers each consisting of an a and a P transmembrane subunit which are connected noncovalently. To date, 16 different a and 8 different 1 subunits and 22 different combinations have been identified. Integrin aVp3, also called vitronectin receptor, mediates adhesion to a large number of ligands - plasma proteins, extracellular matrix proteins, cell surface proteins - most of which contain the aminoacid sequence RGD (Cell, 1986, 44, 517-518; Science 1987, 238, 491-497), such as, for example, vitronectin, fibrinogen, fibronectin, von Willebrand factor, thrombospondin, osteopontin, laminin, collagen, thrombin, tenascin, MMP-2, bone sialoprotein 1l, various viral, parasitic and bacterial proteins, natural integrin antagonists such as disintegrins, neurotoxins - mambin - and leech proteins - decorsin, ornatin - and some non-RGD ligands such as, for example, Cyr-61, PECAM (L. Piali, J. Cell Biol. 1995, 130, 451-460; Buckley, J. Cell Science 1996, 109, 437-445, J. Biol. Chem. 1998, 273, 3090-3096). Several integrin receptors show cross-reactivity with ligands which contain the RGD motif. Thus, integrin allbps, also called platelet fibrinogen receptor, recognizes fibronectin, vitronectin, thrombospondin, von Willebrand factor and fibrinogen. Integrin a3 is expressed inter alia on endothelial cells, blood platelets, monocytes/macrophages, smooth muscle cells, some B cells, fibroblasts, osteoclasts and various tumor cells such as, for example, melanomas, glioblastomas, carcinomas of the lung, breast, prostate and bladder, osteosarcomas or neuroblastomas.
-2 Increased expression is observed under various pathological conditions, such as, for example, in the prothrombotic state, in cases of vessel injury, tumor growth or metastasis or reperfusion and on activated cells, in particular on endothelial cells, smooth muscle cells or 5 macrophages. Involvement of integrin a3 has been detected inter alia in the following pathological states: cardiovascular disorders such as atherosclerosis, restenosis after vessel injury, and ) angioplasty (neointima formation, smooth muscle cell migration and proliferation) (J. Vasc. Surg. 1994, 19, 125-134; Circulation 1994, 90, 2203-2206), acute kidney failure (Kidney Int. 1994, 46, 1050-1058; Proc. NatI. Acad. Sci. 1993, 90, 5700 5704; Kidney Int. 1995, 48, 1375-1385), angiogenesis-associated microangiopathies such as, for example, diabetic retinopathy or rheumatoid arthritis (Ann. Rev. Physiol 1987, 49, 453-464; Int. Ophthalmol. 1987, 11, 41-50; Cell 1994, 79, 1157-1164; J. Biol. Chem. 1992, 267, 10931-10934), arterial thrombosis, stroke (phase il studies with ReoPro, Centocor Inc., 8' annual European Stroke Meeting), cancers such as, for example, in tumor metastasis or tumor growth (tumor-induced angiogenesis) (Cell 1991, 64, 327-336; Nature 1989, 339, 58-61; Science 1995, 270, 1500 1502), osteoporosis (bone resorption after proliferation, chemotaxis and adhesion of osteoclasts to bone matrix) (FASEB J. 1993, 7,1475-1482; Exp. Cell Res. 1991, 195, 368-375, Cell 1991, 64, 327-336), high blood pressure, psoriasis, hyperparathyroism [sic], Paget's disease, malignant hypercalcemia, metastatic osteolytic lesions, inflammation, heart failure, CHF, and for antiviral, antiparasitic or antibacterial therapy and prophylaxis (adhesion and internalization). Because of its key role, pharmaceutical preparations which contain low molecular weight -3 integrin a3 antagonists are of great therapeutic and diagnostic use inter alia for the said indications. Advantageous a0B 3 integrin receptor antagonists bind to the integrin aEVB 3 receptor with increased affinity. Particularly advantageous ax3 integrin receptor antagonists additionally have increased selectivity for integrin av3 3 and have less effect on integrin Uilp 3 by a factor of at least 10, preferably by a factor of at least 100. An integrin av33 antagonist effect has been shown, and a beneficial in vivo effect has been demonstrated, for a large number of compounds such as anti-cVP3a monoclonal antibodies, peptides containing the RGD binding sequence, natural RGD-containing proteins (for example disintegrins) and low molecular weight compounds (FEBS Letts 1991, 291, 50-54; J. Biol. Chem. 1990, 265, 12267-12271; J. Biol. Chem. 1994, 269, 20233-20238; J. Cell Biol 1993, 51, 206-218; J. Biol. Chem. 1987, 262, 17703-17711; Bioorg. Med. Chem. 1998, 6, 1185-1208). WO 9708145 describes meta-guanidino, urea, thiourea or azacyclic aminobenzoic acid derivatives and their use as (VP 3 integrin receptor antagonists. It is an object of the present invention to provide novel integrin receptor antagonists with advantageous properties. We have found that this object is achieved by compounds of the formula I A-E-G-L where A, E, G and L have the following meanings: L a structural element of the formula IL
R
4
R
2
R
3 -4 where a is 0 or 1, 5 T is a COOH group or a radical which can be hydrolyzed to COOH,
R
2 is hydrogen, NHSO 2
R
2 1 , NHCOR 21 or NHCOOR22, where
R
21 is a branched or unbranched, optionally substituted C-C 6 -alkyl, C3-Ce cycloalkyl, C-C 4 -alkyl-C 3
-C
6 -cycloalkyl radical, C 5
-C
1 2 -bicycloalkyl or C6
C
18 -tricycloalkyl radical, an up to trisubstituted, with identical or different radicals, aryl, alkylaryl, hetarylalkyl radical or 3- to 6-membered, saturated, unsaturated or aromatic heterocycle which may contain up to three different or identical heteroatoms 0, N, S, it being possible for two radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and this ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring,
R
22 is a branched or unbranched, optionally substituted C-C 6 -alkyl radical or an optionally substituted aryl or alkylaryl radical,
R
3 is hydrogen or -(CH2)b-(X)c-R where b is 0, 1, 2 or 3, c is 0 or 1, X is -S0 2 -, -S-, -0-, -CO-, -NH-SO 2 -, -0-CO-, -CO-0-, -NH-CO-, -CO-NH-,
-CO-N(R
3 1 )-, -N(R 31 )-CO-, -S0 2 -NH-, -S0 2
-N(R
3 1 )- or -N(R 31 )-S0 2 -,
R
3 1 is hydrogen, a hydroxyl group, a branched or unbranched, optionally -5 substituted Cl.C 6 -alkyl, C-C 4 -alkoxy, -0-alkylaryl or -0-aryl radical, an amino radical with primary or optionally secondary or tertiary substitution, an optionally C 1
.C
4 -alkyl- or aryl-substituted C 2
-C
6 -alkynyl or C 2
-C
6 -alkenyl radical, a C 5
-C
1 2 -bicycloalkyl, C 6
-C
1 8 -tricycloalkyl radical or a 3- to 6 5 membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms 0, N, S, C 3
-C
8 -cycloalkyl, aryl or hetaryl radical, it being possible for two radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to 3 three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring, and
R
4 is hydrogen, or a branched or unbranched, optionally substituted C 1
-
4 -alkyl,
C
3
-C
6 -alkenyl, C 3
-C
6 -alkynyl or C 3
-C
6 -cycloalkyl radical, G a structural element of the formula IG R6 /N IG ) d R5 where d is 0, 1 or 2,
R
5 is hydrogen, a hydroxyl group, a branched or unbranched, optionally substituted C-C 6 -alkyl, C-C 4 -alkoxy, -0-alkylaryl or -0-aryl radical, an amino radical with primary or optionally secondary or tertiary substitution, an optionally C-C 4 -alkyl- or aryl-substituted C 2
-C
6 -alkynyl or C 2
-C
6 -alkenyl radical, a C 5
-C
12 -bicycloalkyl, C 6
-C
1 8 -tricycloalkyl radical or a 3- to 6 membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms 0, N, S, C 3
-C
8 -cycloalkyl, aryl or hetaryl -6 radical, it being possible for two radicals together to be a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or 5 aromatic ring can be fused to this ring, or the side chain of a natural amino acid,
R
6 is hydrogen or a branched or unbranched, optionally substituted C1-C4 alkyl, C 3
-C
6 -alkenyl, C 3
-C
6 -alkynyl or C 3
-C
6 -cycloalkyl radical, D E a structural element of the formula IE -(NH)g-(CH 2 )rQ-(CH 2 )e-CO- IE where e is0,1or2, f is0or1, g is0or1, Q is a doubly linked, optionally substituted hetaryl radical, it being possible for two substituents together to be a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and this ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring, A one of the structural elements of the formulae 1 to IA 20 -7 16 16 16 R A R IA2 RR IA 3 N N R 13 0IA 1A 4 R N Il 1s 11s 2Z N R R 1 i R"R 1 N IA 1 1-N IA z IA 1 0 N ZN 1,5 115 2Z A N 12 13 R R 'is R 0 N 4 H3C N 1 5 IA1 6 H C N R H A17 A i 1 19 0IA 20 H where
R
10 , R' are, independently of one another, hydrogen, -(CH 2 )h-(Y)i-Rl 01 , or the two radicals together are a 3- to 8-membered, optionally substituted, saturated, unsaturated or aromatic N-heterocycle which may additionally contain two other, identical or different heteroatoms 0, N or S, where h is 0, 1, 2 or 3, -8 i is 0 or 1, Y is -S02-, -S-, -0-, -CO-, -NH-SO 2 -, -O-CO-, -CO-0-, -NH-CO-, -CO-NH-,
-CO-N(R
1 01 )-, -N(R 1 01 )-CO-, -S0 2 -NH-, -N(Rlo')-S0 2 - or -S0 2
-N(R
1 0 1 )- and 5
R
101 is a hydroxyl group, a branched or unbranched, optionally substituted C
C
6 -alkyl, C 1
-C
4 -alkoxy, -0-alkylaryl or -0-aryl radical, an amino radical with primary or optionally secondary or tertiary substitution, an optionally C1-C4 alkyl- or aryl-substituted
C
2
-C
6 -alkynyl or C 2
-C
6 -alkenyl radical, a C 5
-C
12 ) bicycloalkyl, C6-C1-tricycloalkyl radical or a 3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms 0, N, S, C 3
-
8 -cycloalkyl, aryl or hetaryl radical, it being possible for two radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring, R12 is a branched or unbranched, optionally substituted C 1
-C
4 -alkyl, alkylaryl, C3-C6 cycloalkyl or C1-C4-alkyl-C 3
-C
6 -cycloalkyl radical or an optionally substituted aryl radical,
R
13 is hydrogen, -OH, -CN, -CONH 2 , a branched or unbranched, optionally substituted C-C 4 -alkyl, C-C 4 -alkoxy or -OCO-C-C 4 -alkyl radical, or an optionally substituted alkylaryl, -0-alkylaryl, -OCO-aryl, -OCO-alkylaryl or -OCO-allyl radical,
R
14 is hydrogen, a branched or unbranched, optionally substituted C-C 4 -alkyl, alkyl aryl, -C02-Cl-C 4 -alkyl, -CO 2 -alkylaryl, -C0 2 -allyl, -CO-C-C 4 -alkyl, -CO-alkylaryl or -CO-allyl radical,
R
1 5 is hydrogen, a branched or unbranched, optionally substituted C-C 4 -alkyl radical or an optionally substituted aryl or alkylaryl radical.
R
1 6 , R" are, independently of one another, -NH 2 , halogen or a branched or unbranched, optionally substituted C-C 4 -alkyl or C-C 4 -alkoxy radical or an optionally substituted aryl radical, -9 ZI, Z 2 , Z 3 , Z 4 are, independently of one another, CH, C-CH 3 , C-OCH 3 , C-Cl or N and the physiologically tolerated salts, prodrugs and the enantiomerically pure or diastereomerically pure and tautomeric forms. T in the structural element L means a COOH group or a radical which can be hydrolyzed to COOH. A radical which can be hydrolyzed to COOH means a radical which is converted into a COOH group after hydrolysis. A group which may be mentioned as an example of a radical T which can be hydrolyzed to COOH is 0 -II in which R' has the following meaning: a) OM, where M can be a metal cation such as an alkali metal cation such as lithium, sodium, potassium, the equivalent of an alkaline earth metal cation such as calcium, magnesium and barium, or an environmentally compatible organic ammonium ion such as tertiary C 1
-C
4 -alkylammonium or an ammonium ion, such as, for example, ONa, OK or OLi, b) a branched or unbranched, optionally halogen-substituted C 1
-C
8 -alkoxy radical such as, for example, methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2 methylpropoxy, 1,1-dimethylethoxy, in particular methoxy, ethoxy, 1-methylethoxy, pentoxy, hexoxy, heptoxy, octoxy, difluoromethoxy, trifluoromethoxy, chlorodifluoro methoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 1,1,2,2-tetrafluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-1,1,2-trifluoroethoxy or pentafluoroethoxy c) a branched or unbranched, optionally halogen-substituted C 1
-C
4 -alkylthio radical such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2 methylpropylthio or 1,1 -dimethylethylthio radical d) an optionally substituted -0-alkylaryl radical such as, for example, -O-benzyl - 10 e) R 1 also a radical of the formula -(O)m-N(R 18
)(R'
9 ), in which m is 0 or 1, and R 18 and R' 9 , which may be identical or different, have the following meaning: hydrogen, 5 Cl-C 8 -alkyl, such as, for example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methyl propyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2 dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1 methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, 1,1-dimethylbutyl, D 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1 ethylbutyl, 2-ethylbutyl, heptyl or octyl,
C
3
-C
6 -alkenyl such as, for example, 2-propenyl, 2-butenyl, 3-butenyl, 1-methyl-2 propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-2-butenyl, 5 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3 methyl-3-butenyl,. 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-propenyl, 2-hexenyl, 3-hexenyl, 4-hexeny, 5-hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1 methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1 dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3 butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3 dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 1 -ethyl-2-butenyl, 1 -ethyl-3-butenyl, 2-ethyl 2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1 -ethyl-1 -methyl-2-propenyl and 1 -ethyl-2-methyl-2-propenyl, in particular 2-propenyl, 2-butenyl, 3-methyl-2-butenyl and 3-methyl-2-pentenyl,
C
3
-C
6 -alkynyl such as, for example, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2 propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1 -methyl-3-butynyl, 2-methyl-3-butynyl, 1 methyl-2-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4 hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1 methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-pentynyl, 4 methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1 -dimethyl-3-butynyl, 1,2-dimethyl-3 butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1 -methyl-2-propynyl, preferably 2-propynyl, 2-butynyl, 1-methyl-2-propynyl and 1 -methyl-2-butynyl, in particular 2-propynyl,
C
3
-C
8 -cycloalkyl, such as, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl - 11 and cycloheptyl, cyclooctyl, it being possible for these alkyl, cycloalkyl, alkenyl and alkynyl groups each to be substituted, phenyl, optionally substituted one or more times, for example one to three times, by 5 halogen, nitro, cyano, C-C 4 -alkyl, C-C 4 -haloalkyl, CriC 4 -alkoxy, C-C 4 -haloalkoxy or
C-C
4 -alkylthio, such as, for example, 2-fluorophenyl, 3-chlorophenyl, 4-bromophenyl, 2-methylphenyl, 3-nitrophenyl, 4-cyanophenyl, 2-trifluoromethylphenyl, 3-methoxy phenyl, 4-trifluoroethoxyphenyl, 2-methylthiophenyl, 2,4-dichlorophenyl, 2-methoxy-3 methylphenyl, 2,4-dimethoxyphenyl, 2-nitro-5-cyanophenyl, 2,6-difluorophenyl D or R 1 8 and R 19 together form a C4-C 7 -alkylene chain which is closed to a ring, is optionally substituted, for example by C-C 4 -alkyl and may contain a heteroatom selected from the group of oxygen, sulfur or nitrogen, such as, for example, -(CH 2
)
4 -,
-(CH
2
)
5 -, -(CH 2
)
6 -, -(CH 2
)
7 -, -(CH 2
)
2 -0-(CH 2
)
2 -, -CH 2
-S-(CH
2
)
3 -, -(CH 2
)
2 -0-(CH 2
)
3 -, -NH 5 (CH 2
)
3 -, -CH 2
-NH-(CH
2
)
2 -, -CH 2
-CH=CH-CH
2 -, -CH=CH-(CH 2
)
3 -, -CO-(CH 2
)
2 -CO- or
-CO-(CH
2
)
3 -CO-. Preferred T radicals are -COOH, -CO--CrC 8 -alkyl or -CO-0-benzyl. A branched or unbranched C-C 6 -alkyl radical for R 2 1 in the structural element L means, for example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1 dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2 trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl or 1-ethyl-2-methylpropyl, preferably methyl, ethyl, propyl, butyl or i-butyl. A branched or unbranched C3-C 6 -cycloalkyl radical for R21 in the structural element L means, for example, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl. A branched or unbranched Cr1C4-alkyl-C 3
-CO
6 -cycloalkyl radical for R 2 1 in structural element L means an abovementioned C 3
-C
6 -cycloalkyl radical which is a substituent on a Cr 1
C
4 -alkyl radical. The CrCO 6 -alkyl radicals, C 3
-CO
6 -cycloalkyl radicals or C1-C4-alkyl-C 3 -CO-cycloalkyl radical may be substituted by up to 5 identical or different radicals selected from the group of halogen, aryl or hetaryl.
-12 A C 5
-C
12 -bicycloalkyl radical for R 21 means, for example, indanyl, norbornyl or camphyl, and a C 6
-C
18 -tricycloalkyl radical means, for example, adamantyl. 5 An up to trisubstituted, with identical or different radicals, aryl, alkylaryl, alkylhetaryl radical or 3- to 6-membered, saturated, unsaturated or aromatic heterocycle which may contain up to three different or identical heteroatoms 0, N, S, it being possible for two radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and for the ring to optionally be D substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring to be fused to this ring for R 21 in structural element L means, for example, aryl radicals such as, for example, phenyl, 1 -naphthyl or 2-naphthyl, 5 alkylaryl radicals such as, for example, benzyl or homobenzyl [sic], alkylhetaryl radicals such as, for example, -CH 2 -2-pyridyl, -CH 2 -3-pyridyl, -CH 2 -4-pyridyl,
-CH
2 -2-thienyl, -CH 2 -3-thienyl, -CH 2 -2-thiazoly, -CH 2 -4-thiazoly, CH 2 -5-thiazolyl, -CH 2
-CH
2 -2 pyridyl, -CH 2
-CH
2 -3-pyridyl, -CH2-CH 2 -4-pyridyl,
-CH
2
-CH
2 -2-thienyl, -CH 2
-CH
2 -3-thienyl,
-CH
2
-CH
2 -2-thiazoly, -CH 2
-CH
2 -4-thiazolyl, or -CH 2
-CH
2 -5-thiazolyl, preferably -CH 2 -2 pyridyl, -CH 2 -2-thienyl, or -CH 2 -2-thiazolyl or hetaryl radicals such as, for example, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-oxazolyl, 4-oxazolyl, 5 oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-pyrazolyl, 5 pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl or 6-pyridazinyl, preferably 2-pyridyl, 3-pyridyl, 4 pyridyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5-thiazolyl, it being possible for the aryl radicals, alkylaryl radicals, alkylhetaryl radicals and hetaryl radicals to be substituted by up to three identical or different radicals, for example selected from the following group:
-NO
2 , -NH 2 , -OH, -CN, -COOH, -COO-C-C 4 -alkyl, halogen, a branched or unbranched, optionally substituted C-C 4 -alkyl, Cs-C 6 -cycloalkyl, CI-C 4 -alkoxy, C-C 4 -thioalkyl [sic], -0
CH
2 -COO-Cr C 4 -alkyl, -NH-CO-C-C 4 -alkyl, -CO-NH-C-C 4 -alkyl, -NH-S0 2
-C-C
4 -alkyl, -SO 2 NH-C-C 4 -alkyl, -N(C-C 4 -alkyl) 2 , -NH-C-C 4 -alkyl, or -S0 2
-C-C
4 -alkyl radical, an optionally -13 substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-S0 2 -phenyl, -S0 2 -NH-phenyl, -NH-CO benzyl, -CO-NH-benzyl, -NH-S0 2 -benzyl, -S0 2 -NH-benzyl, an optionally substituted radical S0 2
-NT'T
2 or -CO-NT'T 2 where the two radicals T' and T 2 may form a cyclic amine, or a 3 to 6-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or 5 heterocycle which may contain up to three different or identical heteroatoms 0, N, S, or two radicals together are a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted or another, optionally substituted ring can be fused to this ring. 0 Preferred substituents on the aryl radicals, alkylaryl radicals, alkylhetaryl radicals and hetaryl radicals for R 2 1 are C-C 4 -alkyl, C 3
-C
6 -cycloalkyl, -COOH, -COOMe, -CF 3 , -CN, C-C 4 -alkoxy,
-SCH
3 , -O-CH 2 -COOH, phenyl, -SO 2
CH
3 , -NO 2 , -OH, -NH 2 , -N-pyrrolidinyl, -N-piperidinyl, -N morpholinyl, -N-piperazinyl, -NH-C-C 4 -alkyl, -N(C-C 4 -alkyl) 2 , F, Cl, Br or I. 5 Preferred substituents on the aryl radicals, alkylaryl radicals, alkylhetaryl radicals and hetaryl radicals for R 21 in which two radicals together are a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted or another optionally substituted ring can be fused to this ring, are the following doubly linked structural elements: NO~ N0N A branched or unbranched C-C 6 -alkyl radical for R2 in structural element L means, for example, the C-C 6 -alkyl radicals mentioned above for R 21 , preferably 1,1 -dimethylethyl. Examples of aryl radicals for R2 in structural element L are phenyl, 1 -naphthyl or 2-naphthyl, preferably phenyl; alkylaryl radicals for R 22 in structural element L are preferably benzyl or homobenzyl [sic]. Suitable substituents on the C-C 6 -alkyl radical, aryl radicals or alkylaryl radicals for R2 in structural element L are the substituents mentioned above for the aryl radicals, the alkylaryl radicals, alkylhetaryl radicals and hetaryl radicals of R 2
.
- 14 In the radical R3 in structural element L, the index b can be 0, 1, 2 or 3, preferably 0, 1 or 2, and the index c can be 0 or 1. The radical X is a doubly linked radical selected from the group of -SO 2 -, -S-, -0-, -CO-, -NH-SO 2 -, -O-CO-, -CO-0-, -NH-CO-, -CO-NH-, -CO-N(R 31 )-, 5 -N(R 31 )-CO-, -S0 2 -NH-, -S0 2
-N(R
31 )- or -N(R 31 )-S0 2 -. In the case of radicals which are disubstituted by R 3 , the two R radicals can be identical or different. A branched or unbranched C-C 6 -alkyl radical for R 31 in structural element L means, for example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-di D methylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2 dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3 dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl or 1-ethyl-2-methylpropyl, preferably methyl, ethyl, propyl, butyl, iso-propyl, sec-butyl and tert-butyl. A branched or unbranched C-C 4 -alkoxy radical for R 31 in structural element L means, for example, methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2 methylpropoxy or 1,1 -dimethylethoxy, in particular methoxy, ethoxy or 1 -methylethoxy. Examples of -0-alkylaryl or -0-aryl radicals are -0-phenyl, -0-1-naphthyl, -O-2-naphthyl or -0-benzyl. The C-C 6 -alkyl, C-C 4 -alkoxy radicals of R 31 in structural element L can be substituted by up to five identical or different radicals selected from the group of halogen, aryl or hetaryl. Substituted -0-alkylaryl or -0-aryl radicals mean, for example, the abovementioned -0-alkyl aryl or -0-aryl radicals, it being possible for the aryl moiety to be substituted by up to three identical or different radicals selected from the following group:
-NO
2 , -NH 2 , -OH, -CN, -COOH, -COO-C-C 4 -alkyl, halogen, a branched or unbranched, optionally substituted C-C 4 -alkyl, C3-C 6 -cycloalkyl, C-C 4 -alkoxy, C-C 4 -thioalkyl [sic], -0
CH
2
-COO-C-C
4 -alkyl, -NH-CO-C-C 4 -alkyl, -CO-NH-C-C 4 -alkyl, -NH-SO 2
-C-C
4 -alkyl, -SO 2 NH-C-C 4 -alkyl, -N(C-C 4 -alkyl) 2 , -NH-C-C 4 -alkyl, or -S0 2
-C-C
4 -alkyl radical, an optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-S0 2 -phenyl, -S0 2 -NH-phenyl, -NH-CO benzyl, -CO-NH-benzyl, -NH-S0 2 -benzyl, -S0 2 -NH-benzyl, an optionally substituted radical -S0 2 -NTlT 2 or -CO-NT'T 2 where the two radicals T' and T 2 may form a cyclic amine, or a 3 to 6-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or -15 heterocycle which may contain up to three different or identical heteroatoms 0, N, S, or two radicals together are a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted or another, optionally substituted ring can be fused to this ring. 5 An amino radical with primary or optionally secondary or tertiary substitution for R 31 in structural element L means a primary amino radical -NH 2 , a secondary amino radical
-NH(R
3 11 ) or a tertiary amino radical -N(R 3 1
)(R
312 ), where 0 R 31 1 and R 312 can be, independently of one another, C 1
-C
4 -alkyl or C 3
-C
6 -cycloalkyl as mentioned above, optionally substituted aryl, preferably phenyl, alkylaryl, preferably benzyl, CO-C-C 4 -alkyl, preferably -CO-CH 3 or -CO-aryl, preferably -CO-phenyl. In the case where c = 1 and X = CO, the corresponding amide residues result. 5 Cyclic tertiary amide residues or amino radicals result in the case where R 31 is one of the heterocyclic systems described below, which is linked via the ring nitrogen to X = CO or directly. Examples of preferred amide residues -X-R 31 are 0 0 0 N r N O-\ A C 2
-C
6 -alkynyl or C 2
-C
6 -alkenyl radical which is optionally substituted by C-C 4 -alkyl or aryl for R 31 in the structural element L means, for example, C 2
-C
6 -alkynyl radicals such as, for example, ethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 2-pentynyl, 3 pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-methyl-2-butynyl, 1,1 dimethyl-2-propynyl, 1-ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl 2-pentynyl, 1-methyl-2-pentynyl, [sic] 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3 pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2 butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2 butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl or 1-ethyl-1 -methyl-2-propynyl, preferably 2 propynyl or ethynyl or C 2
-C
6 -alkenyl radical such as, for example, vinyl, 2-propenyl, 2-butenyl, 3-butenyl, 1 methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-2 butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-Methyl-3-butenyl, 3 methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-propenyl, 2- -16 hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1 -methyl-2-pentenyl, 2-methyl-2-pentenyl, 3 methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl 4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2 butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl 5 2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-2-butenyl, 2,3 dimethyl-3-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1 -methyl-2-propenyl or 1-ethyl-2-methyl-2-propenyl, in particular 2-propenyl or vinyl 0 which can be substituted by optionally substituted C-C 4 -alkyl radicals, or aryl radicals as mentioned above, preferably phenyl, such as, preferably, phenylethynyl or phenylethenyl. A C 5
-C
1 2 -bicycloalkyl radical for R 31 means, for example, indanyl, norbornyl or camphyl, and a C 6
-C
18 -tricycloalkyl radical means, for example, adamantyl. 5 A 3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms 0, N, S, C 3
-C
8 -cycloalkyl, aryl or hetaryl radical, it being possible for two radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle ) which may contain up to three different or identical heteroatoms 0, N, S, and for the ring to optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring to be fused to this ring, for R ' in structural element L means, for example 3- to 6-membered, saturated or unsaturated heterocycles which may contain up to three 5 different or identical heteroatoms 0, N, S, such as N-pyrrolidinyl, N-piperidinyl, N hexahydroazepinyl, N-morpholinyl or N-piperazinyl, it being possible for free amine protons in heterocycles with free amine protons, such as, for example, N-piperazinyl, to be replaced by conventional amine protective groups such as, for example, methyl, benzyl, Boc (tert butoxycarbonyl), Z (benzyloxycarbonyl), tosyl, -SO 2
-C-C
4 -alkyl, -S0 2 -phenyl or -S0 2 -benzyl,
C
3
-C
8 -cycloalkyl radicals as described above for R 21 aryl radicals such as, for example, phenyl, 1 -naphthyl or 2-naphthyl or hetaryl radicals such as, for example, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-oxazolyl, 4-oxazolyl, 5 oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-pyrazolyl, 5- -17 pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl or 6-pyridazinyl, preferably 2-pyridyl, 3-pyridyl, 4 pyridyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5-thiazolyl, 5 it being possible for the heterocyclic, C3-C 8 -cycloalkyl, aryl and hetaryl radicals optionally to be substituted by up to three identical or different radicals, for example selected from the following group:
-NO
2 , -NH 2 , -OH, -CN, -COOH, -COO-C-C 4 -alkyl, halogen, a branched or unbranched, 0 optionally substituted C-C 4 -alkyl, C 3
-C
6 -cycloalkyl, C-C 4 -alkoxy, C-C 4 -thioalkyl [sic], -0
CH
2
-COO-C-C
4 -alkyl, -NH-CO-C-C 4 -alkyl, -CO-NH-C-C 4 -alkyl, -NH-S0 2
-C-C
4 -alkyl, -SO 2 NH-C-C 4 -alkyl, -N(C-C 4 -alkyl) 2 , -NH-C-C 4 -alkyl, or -S02-Cl-C 4 -alkyl radical, an optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-S0 2 -phenyl, -S0 2 -NH-phenyl, -NH-CO benzyl, -CO-NH-benzyl, -NH-S0 2 -benzyl, -SO 2 -NH-benzyl, an optionally substituted radical 5 -S0 2 -NTlT 2 or -CO-NT 1
T
2 where the two radicals T and T 2 may form a cyclic amine, or a 3 to 6-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, or two radicals together are a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted or another, optionally substituted ring can be fused to this ring. Preferred substituents of the heterocyclic, C 3
-C
8 -cycloalkyl, aryl and hetaryl radicals for R 31 are C-C 4 -alkyl, -COOH, -COOMe, -CF 3 , -CN, C-C 4 -alkoxy, -SCH 3 , -O-CH 2 -COOH, -phenyl,
-SO
2
CH
3 , -NO 2 , -OH, -NH 2 , -N-pyrrolidinyl-, -N-piperidinyl, -N-morpholinyl, -N-piperazinyl,
-NH-C-C
4 -alkyl, -N(C-C 4 -alkyl) 2 , F, Cl, Br or I. Preferred substituents of the heterocyclic, C 3
-C
8 -cycloalkyl, aryl and hetaryl radicals for R 31 in which two radicals together are a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted ring can be fused to this ring, are the following, doubly linked structural elements: -18 H N AN' Examples of the resulting condensed ring systems for R 31 are, for example, the corresponding dioxolanyls, benzopyrrolyls, benzofuryls, benzothienyls or fluorenyls. 5 A branched or unbranched, optionally substituted C 1
-C
4 -alkyl radical for R 4 in structural element L means, for example, methyl, ethyl, propyl, i-propyl, butyl, t-butyl or i-butyl, preferably methyl. A branched or unbranched, optionally substituted C 3
-C
6 -cycloalkyl radical for R 4 in structural element L means the radicals mentioned above for R 21 , which are optionally substituted by up to 5 radicals such as halogen or aryl, preferably cyclohexyl, cyclopentyl or cyclopropyl.
C
3
-C
6 -alkenyl or C 3
-C
6 -alkynyl radicals for R 4 in structural element L are the radicals mentioned above for R 1 8 or R' 9 , preferably allyl or propargyl. Particularly preferred radicals for R 4 are hydrogen, methyl, cyclopropyl, allyl or propargyl, and hydrogen is very particularly preferred. Preferred structural elements L have a = 1, so that a 0-amino acid represents the preferred basic structure of the structural element L. In particularly preferred structural elements L, either the radical R 2 = hydrogen and the radical R 3 may vary widely as described above, or the radical RA 3 = hydrogen and the radical R 2 may vary widely as described above. Very particularly preferred structural elements L have R 2 = H and R 3 may vary widely as described above, or R 3 = H and R 2 = -NHZ, -NH-S0 2 -phenyl or -NH-S0 2 -benzyl, where Z is the benzoxycarbonyl [sic] protective group. In structural element G of the formula IG, R 5 means hydrogen and, independently of R 3 ' in structural element L, the same radicals as described above for R31 or another side chain of a natural amino acid. Preferred R 5 radicals are hydrogen, methyl, ethynyl or methyl-substituted ethynyl, and hydrogen is particularly preferred.
-19
R
6 means, independently of R 4 , the same radicals as described above for R 4 . Preferred R 6 radicals are hydrogen, methyl, allyl, propargyl or cyclopropyl, and hydrogen is particularly preferred. 5 In structural element E of the formula IE, Q means a doubly linked hetaryl radical which is optionally substituted by up to three other radicals, it being possible where appropriate for two radicals together to be a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can D be fused to this ring. A hetaryl radical preferably means a 5- or 6-membered aromatic heterocyclic system which may contain up to three different or identical heteroatoms 0, N, S, it being possible for the free amine protons in heterocycles with free amine protons, such as, for example, imidazolyl, 5 triazolyl, pyrazolyl or pyrrolyl, to be replaced by conventional amine protective groups such as, for example, methyl, benzyl, Boc (tert-butoxycarbonyl), Z (benzoxycarbonyl [sic]), tosyl, S0 2 -Cr C 4 -alkyl, -S0 2 -phenyl or -S0 2 -benzyl. Preferred hetaryl radicals Q which may be listed are the following structures where the points of linkage are indicated by a bond line:
-
~N
Hf HS f A3 --t ~ - J(I N ,-1 0S 0 N N H H N N N Particularly preferred hetaryl radicals Q which may be listed are the following structures where the fixed positions of the points of linkage are indicated by a bond line, and the structures can be incorporated in both orientations: - 20 0 O H N N 0 S S 0' HH H H Very particularly preferred hetaryl radicals Q which may be listed are the following structures where the fixed positions of the points of linkage are indicated by a bond line, and the 5 structures can be incorporated in both orientations: 4N H H S H As mentioned above, the free amine protons of imidazolyl, pyrazole [sic], triazole [sic] or ) pyrrolyl in these preferred and particularly preferred structures can also be replaced by conventional amine protective groups such as, for example, methyl, benzyl, Boc (tert butoxycarbonyl), Z (benzoxycarbonyl [sic]), tosyl, -S0 2
-C-C
4 -alkyl, -S0 2 -phenyl or -SO 2 benzyl. 5 Preferred substitutents of the hetaryl radicals are, independently of one another, one or two radicals selected from the group of -CN, halogen, preferably Cl or F, C 1
-C
4 -alkyl, preferably methyl, C-C 4 -haloalkyl, preferably trifluoromethyl, C-C 4 -alkoxy, preferably methoxy, -NH-C
C
4 -alkyl or aryl, preferably phenyl. The structural element A is one of the structural elements of the formula IA 1 to IA2 -21 R 1 6 16 R 17 A R 1 NyIA2 R317 IA 3 N N 0 1 R1 A 5 6 R N IA7 R R 12 14 N~ Ig N l~9 Z4 N IAlo NZ R R 1 R \ 12
AA
1 3 NN '15 115; R R R O N IA H3)CN I 1 2 1 >_2A N IAN I1l 115 O A1 R R H1 R I A 0 N pr is patcual prfrrd for th tucuaJleetA - 22 The radicals R'" and R 1 are, independently of one another and independently of R 3 , the radicals described above for R 3 in structural element L, preferably C-C 4 -alkyl, C 3
-C
8 -cyclo alkyl, C-C 4 -alkyl-C 3
-C
8 -cycloalkyl, aryl, alkylaryl, hetaryl or alkylhetaryl, it being possible for the aryl, alkylaryl, hetaryl and alkylhetaryl radicals to carry up to three identical or different 5 radicals of the group F, Cl, Br or I, C-C 4 -alkyl, C 3
-C
6 -cycloalkyl, -COOH, -COOMe, -CF 3 , -CN, C 1
-C
4 -alkoxy, -SCH 3 , -O-CH 2 -COOH, phenyl, -SO 2
CH
3 , -NO 2 , -OH, -NH 2 , -N pyrrolidinyl, -N-piperidinyl, -N-morpholinyl, -N-piperazinyl, -NH-C-C 4 -alkyl, -N(C-C 4 -alkyl) 2 ,
-NH-CO-C-C
4 -alkyl, -CO-NH-C-C 4 -alkyl, -NH-S0 2
-C-C
4 -alkyl, -S0 2
-NH-C-C
4 -alkyl, or -S0 2
-C-C
4 -alkyl, optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-S0 2 -phenyl, 0 -S0 2 -NH-phenyl, -NH-CO-benzyl, -CO-NH-benzyl, -NH-S0 2 -benzyl, -S0 2 -NH-benzyl, optionally substituted -S0 2
-NT
1
T
2 or -CO-NT'T 2 , where the two radicals T' and T 2 may form a cyclic amine, or the two radicals R 1 0 and R" together a 3- to 8-membered, optionally substituted, 5 saturated, unsaturated or aromatic N-heterocyclic system which may additionally contain two other identical or different heteroatoms 0, N, or S, such as, for example, pyrrolidinyl, piperidinyl, hexahydroazepinyl, piperazinyl or morpholinyl. R1 2 is a branched or unbranched, optionally substituted C-C 4 -alkyl, alkylaryl, C 3
-C
6 -cycloalkyl or C-C 4 -alkyl-C 3
-C
6 -cycloalkyl radical or an optionally substituted aryl radical as described above for R 21 A branched or unbranched, optionally substituted C-C 4 -alkoxy or -0-alkylaryl radical for R' 3 means the corresponding radicals as described above for R 3 , preferably methoxy or benzyloxy. The radicals -OCO-C-C 4 -alkyl-, -OCO-aryl-, -OCO-alkylaryl- or -OCO-allyl- are comprised of the group -OCO- and the C-C 4 -alkyl, aryl or alkylaryl radicals described above under R 31 , or the allyl radical. Preferred R 13 radicals are hydrogen, -OH, -O-benzyl, -OCO-phenyl, -OCO-benzyl, -OCO allyl, -CN or -CO-NH 2 . Analogously, the radicals -C0 2
-C
1
.
4 -alkyl-, -CO 2 -alkylaryl-, -C0 2 -allyl-, -CO-C-C 4 -alkyl-, -CO alkylaryl- or -CO-allyl for the radical R 14 are composed of the group -CO0 2 -[sic] or -CO- and the C-C 4 -alkyl, aryl radical described above under R31 or the allyl radical. Preferred radicals for R 1 4 are hydrogen, methyl, benzyl, -COO-benzyl, -COO-allyl, -CO-benzyl or -CO-allyl. R ' 5 is hydrogen, a branched or unbranched, optionally substituted C-C 4 -alkyl radical or an -23 optionally substituted aryl or alkylaryl radical as described above for R or R 4 . Preferred R 1 radicals are hydrogen, methyl, benzyl or phenyl. R", R 17 are, independently of one another, -NH 2 , halogen, such as Cl, Br, I or F or a 5 branched or unbranched, optionally substituted C 1
-C
4 -alkyl or C-C 4 -alkoxy or optionally substituted aryl radical as described above for R 31 , preferably NH 2 , Cl, F, methyl, methoxy or phenyl. Z', Z 2 , Z 3 , Z 4 are, independently of one another, CH, C-CH 3 , C-OCH 3 , C-Cl or N, it being 0 preferred that Z' and Z 2 or Z 2 and Z 3 or Z 3 and Z 4 are not simultaneously N. Unless specified in detail, substituted aryl, alkylaryl, hetaryl or alkylhetaryl radicals in the description mean aryl, alkylaryl, hetaryl or alkylhetaryl radicals which may be substituted by up to three identical or different radicals selected from the following group:
-NO
2 , -NH 2 , -OH, -CN, -COOH, -O-CH 2 -COOH, -COO-C-C 4 -alkyl, halogen, a branched or unbranched, optionally substituted C-C 4 -alkyl, C 3
-C
6 -cycloalkyl, Cr C 4 -alkoxy, Cr C 4 -thioalkyl [sic], -O-CH 2
-COO-C-C
4 -alkyl, -NH-CO-Cr-C 4 -alkyl, -CO-NH-Cr-C 4 -alkyl, -NH-S0 2
-C
1 -C4 alkyl, -S0 2 -NH-Cr-C 4 -alkyl, -N(C 1
-C
4 -alkyl) 2 , -NH-Cr-C 4 -alkyl, or -S0 2 -Cr-C 4 -alkyl radical, an optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-S0 2 -phenyl, -S0 2 -NH-phenyl, -NH-CO-benzyl, -CO-NH-benzyl, -NH-S0 2 -benzyl, -SO 2 -NH-benzyl, an optionally substituted radical -S0 2
-NT'T
2 or -CO-NT 1
T
2 where the two radicals T' and T 2 may form a cyclic amine, or a 3- to 6-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, or two radicals together are a fused, saturated, unsaturated or aromatic carbocycle or hetero cycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted or another, optionally substituted ring can be fused to this ring. The compounds of the formula I and also the intermediates for their preparation may have one or more asymmetric substituted carbon atoms. The compounds may be in the form of pure enantiomers or pure diastereomers or mixture thereof. It is preferred to use an enantiomerically pure compound as active ingredient. The compounds of the formula I may also be in the form of physiologically tolerated salts. The compounds of the formula I may also be in a prodrug form in which the compounds of the formula I are liberated under physiological conditions. Reference may be made here for -24 example to the group T in structural element L, which in some cases contains groups which can be hydrolyzed under physiological conditions to the free carboxyl group. Derivatized structural elements A which liberate the structural element A under physiological conditions are also suitable. 5 In a preferred embodiment of the compounds of the formula 1, the indices a, e, f and g and the heterocycle 0 are chosen so that the distance between the group T and the structural element A is from 10 to 14 atomic linkages, preferably 11 to 13 atomic linkages, along the shortest possible route along the molecule backbone. D Further preferred compounds of the formula I have the preferred structural elements A of the formula IA 1 , IA 2A 3A, A A, A10 or IA13 while the structural elements E, G and L may vary widely as described above. 5 Further preferred compounds of the formula I have the particularly preferred structural element A of the formula I A 4 , while the structural elements E, G and L may vary widely as described above. Particularly preferred compounds of the formula I have the preferred structural elements A of the formula IA1, IA 2 , A 3 , IA IA 5A, IA 1 0 or IA 1 3 and the preferred region of the structural element L, while the structural elements E and G may vary widely as described above. Further particularly preferred compounds of the formula I have the particularly preferred structural element A of the formula IA 4 and the preferred region of the structural element L, while the structural elements E and G may vary widely as described above. Further particularly preferred compounds of the formula I have the preferred structural element A of the formula IA 4 and the preferred region of the structural element E, while the structural elements L and G may vary widely as described above. Very particularly preferred compounds of the formula I have the preferred structural element A of the formula IA 4 , the preferred region of the structural element E and the preferred region of the structural element L, while the structural element G may vary widely as described above. Further very particularly preferred compounds of the formula I have the preferred region of the structural element A, the preferred region of the structural element E and the preferred -25 region of the structural element G, while the structural elements [sic] L may vary widely as described above. Extremely preferred compounds of the formula I have the preferred structural element A of 5 the formula IA 4 and the preferred regions of the structural elements E, G and L. Very preferred compounds of the formula I are listed in the following table, where "compound number" stands for the number of an individualized compounds [sic] A-E-G-L of the formula I, the compound number and the respective compound are separated by a colon, and the 0 meaning of the abbreviations of the structural elements A-E-G-L is explained after the table.
- 26 Compound number: A-E-G-L 1 : bhs-25thiaz-nmgly-betaoxaz 2: phhs-24thiaz-bala-betabph 5 3: bhs-25thiaz-ser-betapy 4: thazep-24thiaz-gly-betal 3bendi 5: bim-24thiaz-giy-betatrif 6: bhs-24thioph-gly-betapyee 7: bhs-me25thioph-ala-beta34meoph O 8: tolhs-24thioph-gly-betafbph 9: tolhs-24thioph-gly-betameph 10: bim-me24thiaz-bala-betaph 11: bhs-me25thioph-Ieu-beta34meoph 12: ibhs-24thioph-gly-betathiome 5 13: bhs-nme35pyr-gly-betabthioph 14: tolhs-nme35pyr-gly-betafu2 15: bhs-ithiadiaz-gly-betahmofu 16: phhs-nme35pyr-bala-betacph 17: impy-24thiaz-bala-betaf u3 3 18: tolhs-25methiaz-bala-psdaptb 19: sabhs-25thiaz-gly-psdap 20: bhs-24thioph-gly-betadcphtb 21: 2py-nme35pyr-Ieu-psdap 22: bhs-nme35pyr-gly-aspbzla 523: phhs-me24thiaz-gly-zdap 24: bhs-25thiaz-bala-betameph 25: phhs-me24thiaz-ala-beta34meoph 26: tolhs-25methiaz-gly-beta34meoph 27: ibhs-ithiadiaz-gly-betaf bph 28: tolhs-ithiadiaz-bala-asppha 29: phhs-ithiadiaz-bala-betaamibe 30: tolhs-24thioph-bala-betabmph 31: phhs-25methiaz-bala-betaol 32: bhs-25oxaz-bala-betamethi 33: ibhs-24thiaz-bala-betahni 34: gua-24thiaz-gly-betaftrif 35: bhs-24thiaz-gly-betafphe -27 36: tolhs-oxadiaz-gly-psdaptb 37: phhs-25methiaz-bala-betatbuph 38: bhs-24thiaz-nmgly-betathio3 39: phhs-24thioph-gly-betatos 5 40: 2py-thiadiaz-leu-psdap 41: dhim-35py-gly-betameph 42: bhs-ithiadiaz-gly-aspaba 43: phhs-oxadiaz-gly-beta4bph 44: bhs-25thiaz-gly-csdap 0 45: ibhs-25thiaz-gly-betahph 46: phhs-25methiaz-gly-betahdbph 47: bim-me25thioph-gly-betaph 48: ibhs-ithiadiaz-bala-beta3quin 49: tolhs-oxadiaz-gly-betadhbfu 5 50: bhs-oxadiaz-leu-psdap 51: impy-24thioph-bala-betainyl 52: bhs-25methiaz-ala-beta23meoph 53: phhs-24thiaz-gly-betabnaphth 54: impy-42nmeim-bala-betathiome 3 55: bim-35thioph-ala-betadcph 56: 2py-me24thiaz-gly-betapy 57: phhs-24thioph-bala-betaim id 58: phhs-24thioph-gly-betadhbfu 59: phhs-nme35pyr-bala-betaibph 60: bhs-25thiaz-ser-betameph 61: tolhs-25thiaz-bala-zdap 62: bim-25thiaz-gly-betadcph 63: 2pmhs-42nmeim-gly-betaamibe 64: 2py-24thioph-gly-beta3quin 65: bhs-25methiaz-gly-betamethioph 66: tolhs-ithiadiaz-gly-betafbph 67: phhs-25methiaz-gly-betamethi 68: ibhs-24thiaz-gly-betadtrif 69: bhs-24thioph-gly-betabthioph 70: tolhs-25oxaz-gly-betabmph 71: ibhs-ithiadiaz-bala-suabu 72: bhs-42oxaz-gly-betapy -28 73: tolhs-ithiadiaz-gly-betapyr 74: 2py-24im-gly-psdap 75: thpy-24thiaz-gly-betadcph 76: phhs-24thiaz-gly-betampy 5 77: bhs-25methiaz-bala-betadito 78: phhs-25methiaz-bala-suabu 79: bhs-25thiaz-bala-beta23meoph 80: bhs-oxadiaz-leu-betapy 81: tolhs-25oxaz-gly-betabnaphth 0 82: dhim-25thiaz-ala-zdap 83: tolhs-ithiadiaz-gly-betaimid 84: bhs-ithiadiaz-bala-betaoxaz 85: bim-25thioph-ala-betameph 86: phhs-25oxaz-bala-beta4bph 5 87: bhs-nme35pyr-nmgly-betainyl 88: phhs-24thiaz-bala-betacbph 89: bhs-25oxaz-bala-betaet 90: bhs-24thioph-bala-betabmph 91: bhs-25oxaz-ala-betaanaphth D 92: ibhs-ithiadiaz-gly-betathiobe 93: bhs-25thiaz-bala-betadito 94: 2py-nme35pyr-bala-betapy 95: tolhs-25oxaz-bala-beta3quin 96: bhs-25thiaz-gly-beta23meoph 97: 2py-25methiaz-gly-betadito 98: ibhs-nme35pyr-bala-betahni 99: tolhs-nme35pyr-gly-betadmph 100: ibhs-ithiadiaz-bala-betabdimo 101: 2py-24thiaz-gly-aspibua 102: ibhs-nme35pyr-bala-betacbph 103: bhs-24thiazme-gly-zdap 104: bhs-24thioph-bala-betao 105: 2py-24im-gly-zdap 106: tolhs-25methiaz-gly-betapytb 107: tolhs-ithiadiaz-gly-psdap 108: phhs-25thiaz-bala-betabthioph 109: bhs-nme35pyr-gly-betafph -29 110: bhs-25methiaz-ala-betadhbfu 111: bim-25fur-ala-psdap 112: 2pmhs-24thiaz-gly-betapy 113: bhs-24thiaz-bala-betaphethio 5 114: bhs-25methiaz-bala-betapytb 115: bhs-25methiaz-bala-betambiph 116: ibhs-25thiaz-gly-betainyl 117: phhs-nme35pyr-bala-betabthioph 118: bhs-25thiaz-bala-betacph 0 119: bim-26py-ala-betadcph 120: phhs-24thioph-gly-betaphethio 121: gua-24thiaz-gly-betabthioph 122: phhs-24thioph-bala-betaph 123: bhs-25thiaz-gly-betaibph 5 124: ibhs-nme35pyr-bala-betathio3 125: tolhs-oxadiaz-gly-betapy 126: tolhs-nme35pyr-bala-beta4bph 127: 2py-me24oxaz-gly-betadcph 128: tolhs-25methiaz-bala-psdapee 3 129: bhs-ithiadiaz-gly-suabu 130: ibhs-25methiaz-bala-beta3quin 131: phhs-25oxaz-gly-betaipr 132: bim-53pyrazo-ala-betadcph 133: tolhs-25oxaz-gly-betapym 134: phhs-25oxaz-gly-betathiobe 135: phhs-me24thioph-ala-betaph 136: tolhs-me25thiaz-leu-betapy 137: hs-25thiaz-bala-betapy 138: bim-42nmeim-leu-betapy 139: tolhs-nme35pyr-bala-betampy 140: bhs-24thioph-gly-betahdcph 141: ibhs-25oxaz-gly-betaimid 142: bhs-oxadiaz-gly-csdap 143: ibhs-25oxaz-gly-betadtrif 144: 2py-53pyrazo-ala-betapy 145: phhs-nme35pyr-gly-betahdbph 146: tolhs-oxadiaz-bala-zdapch -30 147: phhs-oxadiaz-bala-betapych 148: bim-24thioph-gly-betatrif 149: tolhs-25methiaz-bala-betapyr 150: 2py-24thiaz-ala-betapy 5 151: bhs-25thiaz-gly-betapytb 152: tolhs-25oxaz-gly-zdapch 153: bhs-25methiaz-ala-betadcph 154: ibhs-25methiaz-gly-betatos 155: tolhs-25thiaz-gly-beta35dbph 0 156: bim-me24thioph-leu-betadcph 157: bim-nme35pyr-gly-aspbzla 158: ibhs-24thioph-bala-ibsdap 159: gua-24thiaz-gly-betal 3bendi 160: 2py-25methiaz-gly-psdap 5 161: 2py-24thiaz-bala-asppha 162: ibhs-ithiadiaz-bala-betaanaphth 163: bhs-nme35pyr-ala-betameph 164: tolhs-oxadiaz-gly-betapym 165: phhs-ithiadiaz-gly-betaph 0 166: phhs-25methiaz-bala-betadcphtb 167: 2pmhs-24thiaz-gly-betaph 168: gua-24oxaz-gly-betafbph 169: bhs-25oxaz-phg-betapy 170: bhs-25methiaz-bala-betahdbph 5 171: 2py-me24thiaz-bala-beta34meoph 172: bhs-25thiaz-bala-betambiph 173: phhs-25methiaz-bala-betadmph 174: bhs-oxadiaz-gly-zdapch 175: dhim-25thioph-gly-betadcph 0 176: bhs-me25oxaz-gly-zdap 177: ibhs-oxadiaz-gly-betahmo 178: ibhs-25thiaz-gly-betadcph 179: 2py-35fur-gly-zdap 180: bhs-24thiaz-ala-betal 3bendi 5 181: bhs-oxadiaz-gly-betadcph 182: phhs-oxadiaz-bala-betah35dc 183: ibhs-oxadiaz-bala-betaet -31 184: phhs-nme35pyr-gly-betadmph 185: phhs-me24thioph-bala-betapy 186: tolhs-25oxaz-gly-beta34dcph 187: bim-26py-gly-betameph 5 188: ibhs-24thiaz-gly-betadcphee 189: phhs-25thiaz-gly-betacbph 190: tolhs-ithiadiaz-gly-betaphethioa 191: bhs-25methiaz-gly-betafu2 192: 2pmhs-42nmeim-gly-betabenfu 0 193: bhs-25methiaz-gly-beta3quin 194: tolhs-25thiaz-bala-betahdcph 195: 2py-24thioph-bala-betadcph 196: 2py-42nmeim-ala-zdap 197: bim-35thioph-gly-betapy 5 198: bim-me25thioph-leu-zdap 199: bim-25methiaz-bala-betapy 200: tolhs-25thiaz-bala-betaoxaz 201: phhs-25oxaz-gly-betapbiph 202: tolhs-24thioph-bala-ibsdap ) 203: bhs-oxadiaz-gly-zdaptb 204: bim-42oxaz-leu-betapy 205: ibhs-25methiaz-gly-zdaptb 206: ibhs-25methiaz-gly-betaol 207: tolhs-ithiadiaz-gly-beta34dcph 208: phhs-ithiadiaz-gly-betacthioph 209: phhs-24thiaz-bala-betahmofu 210: phhs-ithiadiaz-gly-aspibua 211: phhs-24thiaz-gly-betathioph 212: bhs-25methiaz-gly-betaimid 213: gua-25thiaz-gly-betahdcph 214: bhs-25thiaz-ala-betacph 215: gua-24thiaz-gly-betaet 216: tolhs-25methiaz-bala-betahcbph 217: tolhs-ithiadiaz-gly-beta35dbph 218: ibhs-oxadiaz-gly-betadbph 219: tolhs-24thioph-gly-betathioph 220: bim-53pyrazo-bala-zdap -32 221: bim-me24oxaz-gly-betadcph 222: bim-triaz-gly-psdap 223: phhs-25thiaz-bala-betampy 224: bhs-oxadiaz-gly-betadcphee 5 225: bim-ithiadiaz-leu-zdap 226: 2pmhs-24thiaz-gly-betafph 227: bhs-25thiaz-gly-betathioph 228: gua-24thiaz-bala-betadcph 229: impy-42nmeim-bala-betafph 0 230: tolhs-24thioph-gly-betadmoph 231: ibhs-oxadiaz-bala-betapbiph 232: ibhs-25methiaz-bala-zdapee 233: tolhs-oxadiaz-gly-betaf ph 234: bhs-me24oxaz-bala-beta34meoph 5 235: tolhs-25methiaz-bala-betahbcph 236: bim-42oxaz-leu-betadcph 237: tolhs-oxadiaz-gly-busu2be 238: tolhs-me25thiaz-ala-betapy 239: phhs-oxadiaz-bala-betainyl 240: bhs-oxadiaz-gly-psdaptb 241: phhs-24thiaz-gly-busu2be 242: tolhs-25methiaz-bala-zdapee 243: bhs-25thiaz-nmgly-betahmph 244: bhs-oxadiaz-gly-betapy 245: phhs-25oxaz-gly-betadcphee 246: phhs-24thiaz-gly-betapy 247: tolhs-ithiadiaz-bala-betamesu 248: bhs-25oxaz-nmgly-betal 3bendi 249: phhs-24thiaz-gly-psdapch 250: phhs-25oxaz-bala-asppha 251: phhs-25oxaz-bala-beta3quin 252: phhs-25methiaz-gly-beta3quin 253: phhs-me25oxaz-bala-betadcph 254: phhs-me24thiaz-ala-psdap 255: ibhs-24thioph-gly-betapych 256: phhs-ithiadiaz-bala-betaibph 257: bhs-25oxaz-bala-betaftrif -33 258: bhs-24thiaz-bala-betahc 259: 2py-me24thioph-leu-psdap 260: phhs-24thioph-gly-betahc 261: dhim-26py-gly-betaheph 5 262: phhs-oxadiaz-bala-betaphethio 263: bhs-42nmeim-gly-betahni 264: tolhs-nme35pyr-bala-betahb 265: ibhs-nme35pyr-gly-betathiobe 266: tolhs-25oxaz-gly-betapytb 0 267: 2py-me24oxaz-ala-beta34meoph 268: ibhs-ithiadiaz-gly-betahph 269: bhs-25methiaz-ala-betal 3bendi 270: gua-26py-gly-beta3quin 271: phhs-ithiadiaz-gly-betathiobe 5 272: bhs-oxadiaz-gly-betabpy 273: ibhs-25thiaz-bala-psdapch 274: phhs-ithiadiaz-gly-betacph 275: phhs-24thioph-gly-betabthioph 276: gua-24thiaz-gly-betamesu 0 277: tolhs-24thiaz-gly-betambiph 278: bhs-me24oxaz-leu-betaph 279: 2pmhs-25methiaz-gly-betabpy 280: bhs-ithiadiaz-bala-betathiobe 281: tolhs-25methiaz-bala-betafphe 5 282: tolhs-24thiaz-bala-betahni 283: ibhs-25thiaz-gly-zdap 284: bhs-25thiaz-ala-betaanaphth 285: ibhs-ithiadiaz-bala-betaphethio 286: ibhs-25oxaz-gly-betaheph 287: 2py-me25thioph-leu-zdap 288: phhs-me24thiaz-bala-betaph 289: bim-me25thioph-bala-betapy 290: 2py-25thiaz-bala-betapy 291: phhs-25thiaz-bala-betatbuph 292: bhs-24thioph-ala-betal 3bendi 293: tolhs-25methiaz-bala-betathiobe 294: phhs-25thiaz-bala-betal 3bendi -34 295: bim-nme35pyr-leu-psdap 296: phhs-25methiaz-gly-betatos 297: tolhs-nme35pyr-bala-betaibph 298: phhs-25oxaz-bala-betadcphee 5 299: hs-24thioph-bala-betapy 300: bim-42nmeim-gly-psdap 301: ibhs-nme35pyr-bala-betambiph 302: bhs-nme35pyr-bala-betahdcph 303: tolhs-ithiadiaz-bala-beta34meoph 0 304: bhs-25methiaz-ala-betahph 305: bim-53pyrazo-bala-psdap 306: 2pmhs-25thiaz-gly-betahb 307: 2py-me24thiaz-leu-betadcph 308: gua-24thiaz-gly-betahmph 5 309: ibhs-nme35pyr-gly-betaimid 310: phhs-24thiaz-bala-zdaptb 311: tolhs-24thiaz-gly-betaph 312: gua-24thiaz-gly-betahdcph 313: bhs-25methiaz-bala-betapyee 0 314: 2py-42nmeim-gly-csdap 315: bhs-25oxaz-ala-betadito 316: bhs-nme35pyr-gly-betafu3 317: ibhs-25oxaz-bala-betahdbph 318: phhs-nme35pyr-gly-betabmph 5 319: phhs-ithiadiaz-bala-betapych 320: bim-24thiaz-leu-psdap 321: bhs-oxadiaz-bala-betadcphee 322: tolhs-ithiadiaz-bala-betaol 323: gua-42pym-gly-betabediox 324: bim-24thiaz-gly-asppha 325: tolhs-24thiaz-gly-betahmofu 326: ibhs-oxadiaz-gly-beta23meoph 327: phhs-me24thioph-ala-zdap 328: phhs-me24oxaz-gly-betaph 329: bhs-25oxaz-nmgly-beta23meoph 330: tolhs-ithiadiaz-bala-betadbph 331: bhs-24im-bala-zdap -35 332: phhs-oxadiaz-gly-busu2be 333: ibhs-25methiaz-bala-betathio3 334: tolhs-24thiaz-bala-betabdimo 335: bhs-25oxaz-bala-betaipr 5 336: 2py-me25thiaz-ala-betaph 337: bhs-25methiaz-gly-betapyr 338: tolhs-25oxaz-bala-betainyl 339: ibhs-25oxaz-gly-betaoxaz 340: tolhs-25thiaz-gly-betapyr 0 341: phhs-25methiaz-bala-betacbph 342: bhs-24thioph-gly-betadmoph 343: tolhs-oxadiaz-bala-aspbzla 344: dhim-25thioph-gly-zdap 345: phhs-25oxaz-bala-betafph 5 346: tolhs-25methiaz-bala-betaoxaz 347: ibhs-nme35pyr-bala-aspbzla 348: bhs-oxadiaz-bala-betahcbph 349: phhs-oxadiaz-gly-betameph 350: phhs-me24thioph-leu-betadcph D 351: ibhs-nme35pyr-gly-busu2be 352: dhim-24oxaz-ala-zdap 353: 2py-me24oxaz-ala-betaph 354: phhs-ithiadiaz-gly-betampy 355: bhs-ithiadiaz-gly-psdap 356: ibhs-24thioph-gly-aspbzla 357: bim-ithiadiaz-leu-psdap 358: dhim-24thiaz-gly-betahdcph 359: bim-me25oxaz-ala-betadcph 360: gua-24thiaz-gly-betaoxope 361: bim-nme35pyr-ala-betadcph 362: phhs-24thioph-bala-betabthioph 363: 2py-25methiaz-bala-aspbzla 364: tolhs-nme35pyr-gly-betaet 365: bhs-52thiaz-gly-zdap 366: ibhs-oxadiaz-gly-betafbph 367: bhs-24thiaz-gly-betafu3 368: bim-25thiaz-gly-betapy -36 369: bhs-24thiaz-gly-betah35dc 370: tolhs-24thiaz-bala-aspibua 371: tolhs-24thioph-bala-betadhbfu 372: tolhs-24thioph-gly-psdapee 5 373: ibhs-25thiaz-bala-betapym 374: bhs-52thiaz-ala-betainyl 375: ibhs-25oxaz-bala-betadtrif 376: ibhs-ithiadiaz-gly-betamethioph 377: tolhs-25methiaz-gly-betabpy 0 378: ibhs-25methiaz-bala-beta35dbph 379: ibhs-25oxaz-bala-beta35dbph 380: bhs-me25thiaz-bala-zdap 381: bhs-25oxaz-gly-asppha 382: bhs-25methiaz-bala-betaphethio 5 383: bim-42oxaz-bala-betadcph 384: ibhs-24thiaz-bala-beta3quin 385: bhs-25methiaz-gly-betadcphtb 386: bhs-ithiadiaz-gly-betadcphtb 387: ibhs-25oxaz-bala-betafph 388: tolhs-24thioph-gly-betahmo 389: bhs-24thioph-bala-betafbph 390: phhs-24thiaz-bala-betal 3bendi 391: 2py-24oxaz-bala-zdap 392: phhs-nme35pyr-gly-betadbph 393: bhs-25methiaz-bala-betacph 394: tolhs-25oxaz-gly-betamethioph 395: ibhs-24thiaz-bala-betambiph 396: bhs-24thioph-nmgly-ibsdap 397: phhs-nme35pyr-bala-betahmph 398: dhim-52thiaz-ala-betameph 399: tolhs-oxadiaz-gly-beta3quin 400: bhs-25methiaz-nmgly-betaoxaz 401: bhs-oxadiaz-ala-betafphe 402: phhs-25methiaz-gly-betafluo 403: bhs-25oxaz-leu-betadcph 404: tolhs-25methiaz-gly-betaipr 405: dhim-26py-gly-betahcbph -37 406: bhs-25methiaz-gly-zdapee 407: 2 pmhs-24thioph-gly-betahbcph 408: phhs-ithiadiaz-bala-betahc 409: tolhs-24thiaz-gly-betaipr 5 410: ibhs-nme35pyr-bala-betainyl 411: bhs-42pym-ala-zdap 412: bhs-25oxaz-bala-betaphethio 413: impy-25thiaz-gly-betahmofu 414: bhs-25thiaz-bala-betadmph 0 415: tolhs-me25thioph-ala-betaph 416: bim-24thioph-gly-aspbzla 417: tolhs-nme35pyr-gly-betaheph 418: phhs-25oxaz-bala-betatrif 419: tolhs-24thioph-gly-betathiome 5 420: ibhs-nme35pyr-gly-betathioph 421: ibhs-25methiaz-gly-betambiph 422: bhs-25oxaz-bala-betacthioph 423: ibhs-24thiaz-gly-csdap 424: 2py-ithiadiaz-gly-asppha ) 425: tolhs-25thiaz-gly-betabdimo 426: tolhs-25thiaz-gly-zdap 427: tolhs-25methiaz-bala-betadmoph 428: tolhs-25thiaz-gly-betabediox 429: phhs-25methiaz-gly-betadbph 430: ibhs-oxadiaz-gly-betahni 431: tolhs-24thiaz-bala-betahdbph 432: phhs-25oxaz-gly-betadmoph 433: phhs-24thiaz-gly-betaomebendi 434: tolhs-ithiadiaz-bala-zdapee 435: tolhs-25oxaz-gly-betathiobe 436: phhs-25oxaz-bala-betaibph 437: 2py-25oxaz-leu-zdap 438: bhs-24oxaz-leu-betadcph 439: bhs-nme35pyr-ala-psdap 440: phhs-oxadiaz-bala-betabediox 441: tolhs-oxadiaz-bala-betapbiph 442: 2py-ithiadiaz-bala-aspaba - 38 443: tolhs-24thiaz-bala-psdaptb 444: bhs-24thiaz-gly-busu2be 445: ibhs-25thiaz-giy-betaoxaz 446: bhs-24thioph-gly-betaphethio 5 447: bim-35thioph-bala-betapy 448: dimethpym-25methiaz-gly-betameph 449: 2py-ithiadiaz-bala-zdap 450: bhs-25thiaz-nmgiy-betabpy 451: 2py-35f ur-ala-betapy 0 452: phhs-25oxaz-gly-betamethioph 453: tolhs-me24thioph-bala-betapy 454: tolhs-ithiadiaz-gly-betaf u3 455: gua-26py-gly-betaim id 456: phhs-nme35pyr-bala-betaphethio 5 457: bhs-25oxaz-gly-aspibua 458: ibhs-oxadiaz-gly-betafph 459: ibhs-oxadiaz-gly-betafu3 460: ibhs-24thiaz-bala-betahcbph 461: tolhs-24thioph-gly-betafluo 462: 2 Py-24thioph-Ieu-betapy 463: impy-25oxaz-gly-ibsdap 464: phhs-nme35pyr-gly-aspbzla 465: 4 pmhs-42nmeim-bala-betadcph 466: tolhs-me25thioph-Ieu-beta34meoph 467: phhs-oxadiaz-gly-betaoxaz 468: tolhs-nme3spyr-gly-betamethioph 469: bhs-25thiaz-gly-betaheph 470: phhs-nme35pyr-baa-betaoxaz 471: bhs-24thioph-nmgly-betacph 472: bim-me25oxaz-ala-beta34meoph 473: bhs-25methiaz-gly-betacbph 474: impy-25methiaz-gly-betahmofu 475: dhim-3spyrazo-gly-betameph 476: bim-35tur-ala-zdap 477: phhs-2Soxaz-gly-betahc 478: bhs-24thioph-bala-aspibua 479: 2 py-24thiaz-gly-betacthioph -39 480: bhs-oxadiaz-bala-suabu 481: bhs-25methiaz-gly-aspaba 482: tolhs-nme35pyr-gly-betaipr 483: 2py-ithiadiaz-ala-psdap 5 484: ibhs-ithiadiaz-bala-betathiobe 485: bhs-nme35pyr-bala-betapyee 486: tolhs-25methiaz-bala-betahc 487: tolhs-25oxaz-gly-zdaptb 488: bhs-24thioph-gly-beta23meoph 0 489: tolhs-24thioph-bala-betaphethioa 490: bhs-nme35pyr-bala-betahbcph 491: phhs-25oxaz-gly-betadbph 492: bhs-25methiaz-bala-asppha 493: ibhs-nme35pyr-gly-psdapch 5 494: bhs-oxadiaz-bala-ibsdap 495: bhs-25methiaz-bala-betapy 496: ibhs-24thiaz-gly-betabdimo 497: ibhs-24thiaz-bala-beta34dcph 498: phhs-oxadiaz-gly-betadcphch 499: bim-nme35pyr-gly-betadcph 500: bhs-ithiadiaz-gly-betahc 501: ibhs-ithiadiaz-bala-betathiome 502: bim-me24oxaz-leu-zdap 503: bhs-25oxaz-gly-betadcphee 504: bim-25fur-leu-psdap 505: tolhs-oxadiaz-bala-betatbuph 506: gua-42pym-gly-betadbph 507: ibhs-24thioph-gly-aspaba 508: ibhs-25methiaz-gly-beta34dcph 509: tolhs-ithiadiaz-bala-betahbcph 510: bhs-oxadiaz-nmgly-betaoxaz 511: tolhs-25thiaz-bala-betadbph 512: bhs-oxadiaz-bala-betaomebendi 513: thpym-24thiaz-gly-betameph 514: bhs-ithiadiaz-bala-beta35dbph 515: 2pmhs-25thiaz-gly-betadtrif 516: ibhs-ithiadiaz-bala-psdapch -40 517: phhs-24thioph-bala-betaanaphth 518: bhs-25thiaz-bala-betaet 519: ibhs-ithiadiaz-bala-betahdcph 520: bhs-42oxaz-ala-zdap 5 521: tolhs-24thioph-gly-busu2be 522: bhs-ithiadiaz-gly-betaftrif 523: tolhs-nme35pyr-gly-betadhbfu 524: bhs-24thiaz-gly-aspibua 525: bhs-24thioph-gly-betapy 0 526: ibhs-25oxaz-gly-aspbzla 527: tolhs-24thioph-bala-betadbph 528: phhs-25methiaz-gly-betabenfu 529: bhs-nme35pyr-ala-betadito 530: phhs-me25thiaz-ala-beta34meoph 5 531: ibhs-25methiaz-bala-betamethi 532: ibhs-25oxaz-gly-betahmofu 533: bhs-24thioph-gly-zdapch 534: phhs-24thioph-bala-betah35dc 535: ibhs-24thioph-bala-betahcbph 536: ibhs-ithiadiaz-bala-betahph 537: bhs-ithiadiaz-bala-asppha 538: dhim-25thioph-gly-betameph 539: tolhs-ithiadiaz-gly-betadcphee 540: phhs-oxadiaz-bala-betatbuph 541: bhs-25thiaz-gly-betamethi 542: bhs-ithiadiaz-gly-betahbcph 543: tolhs-25oxaz-bala-betadcphtb 544: phhs-24thiaz-gly-betadhbfu 545: ibhs-25oxaz-gly-psdap 546: ibhs-25methiaz-bala-betatrif 547: bhs-ithiadiaz-bala-beta23meoph 548: phhs-25thiaz-gly-betahmofu 549: bhs-24thioph-gly-betamethi 550: ibhs-25oxaz-gly-betadito 551: bhs-25methiaz-gly-betadcph 552: bhs-me24thioph-ala-psdap 553: tolhs-25thiaz-gly-betahni -41 554: ibhs-24thioph-gly-betafu3 555: phhs-24thiaz-gly-betahni 556: 2py-24thioph-gly-aspbzla 557: ibhs-nme35pyr-gly-betaibph 5 558: tolhs-25methiaz-gly-psdapch 559: bhs-ithiadiaz-gly-betaet 560: bhs-nme35pyr-ala-beta34meoph 561: phhs-oxadiaz-gly-betapyr 562: ibhs-25oxaz-gly-zdapch 0 563: bhs-24oxaz-ala-betainyl 564: ibhs-nme35pyr-gly-betahmo 565: bhs-25thiaz-nmgly-beta34dcph 566: bhs-nme35pyr-bala-betaomebendi 567: tolhs-25oxaz-gly-betaph 5 568: bhs-24thiaz-nmgly-betahph 569: bhs-nme35pyr-leu-psdap 570: ibhs-24thioph-gly-betahni 571: ibhs-25oxaz-gly-betaftrif 572: phhs-me24thiaz-leu-zdap D 573: ibhs-24thiaz-gly-betathiobe 574: phhs-25oxaz-bala-betabediox 575: phhs-ithiadiaz-gly-betameph 576: tolhs-ithiadiaz-gly-psdaptb 577: 2py-me25oxaz-leu-zdap 578: dhim-24oxaz-gly-zdap 579: tolhs-oxadiaz-gly-betapbiph 580: tolhs-24thioph-gly-betadcphch 581: bhs-ithiadiaz-bala-psdapee 582: imhs-25methiaz-gly-zdap 583: bhs-25oxaz-gly-betabnaphth 584: bhs-24thiaz-gly-betaftrif 585: phhs-25methiaz-gly-betahmofu 586: phhs-ithiadiaz-bala-betamethi 587: bhs-ithiadiaz-gly-betabdimo 588: dhim-42pym-gly-betainyl 589: bhs-25thioph-bala-betadcph 590: 2py-thiadiaz-leu-betapy -42 591: tolhs-25oxaz-bala-betabmph 592: phhs-25oxaz-gly-betadito 593: bim-ithiadiaz-gly-psdap 594: phhs-24thioph-gly-betaibph 5 595: tolhs-25oxaz-gly-psdapee 596: ibhs-25methiaz-gly-betamesu 597: bhs-oxadiaz-bala-aspaba 598: bhs-oxadiaz-bala-betapym 599: phhs-24thioph-gly-betafu3 0 600: tolhs-24thioph-gly-betaphethioa 601: ibhs-25oxaz-bala-betafphe 602: tolhs-25oxaz-gly-betacbph 603: ibhs-25methiaz-bala-betaipro 604: bhs-nme35pyr-gly-betaipro 5 605: tolhs-24thioph-bala-betahmph 606: tolhs-25methiaz-bala-betadbph 607: bhs-25methiaz-gly-betaamibe 608: impy-24thiaz-gly-betabediox 609: ibhs-oxadiaz-gly-betapym D 610: 2py-25methiaz-ala-betapy 611: tolhs-nme35pyr-bala-betabnaphth 612: phhs-24thioph-gly-beta4bph 613: ibhs-ithiadiaz-bala-betah35dc 614: bhs-oxadiaz-gly-betaomebendi 5 615: tolhs-25methiaz-gly-betafph 616: phhs-25oxaz-bala-betadcphtb 617: ibhs-ithiadiaz-gly-beta35dbph 618: 2py-25oxaz-bala-betadhbfu 619: bhs-25oxaz-gly-betatrif 620: ibhs-25thiaz-gly-zdapch 621: bhs-oxadiaz-gly-betadmoph 622: phhs-nme35pyr-bala-betacthioph 623: phhs-25thiaz-bala-betaoxaz 624: bim-me25oxaz-gly-psdap 625: bhs-25methiaz-ala-betapy 626: ibhs-24thioph-bala-betathioph 627: phhs-25methiaz-gly-suabu -43 628: phhs-ithiadiaz-bala-betacph 629: phhs-25methiaz-gly-betadmoph 630: phhs-ithiadiaz-bala-zdapch 631: phhs-24thiaz-gly-betabediox 5 632: bhs-nme35pyr-bala-betatos 633: tolhs-25oxaz-bala-betaipr 634: bhs-24thioph-gly-betapytb 635: bhs-25methiaz-leu-betapy 636: 4pmhs-24thiaz-gly-betapy 0 637: tolhs-oxadiaz-bala-betapytb 638: tolhs-oxadiaz-gly-beta34meoph 639: bhs-25oxaz-bala-betatbuph 640: ibhs-25oxaz-gly-suabu 641: phhs-25methiaz-gly-psdaptb 5 642: tolhs-25oxaz-bala-betahph 643: ibhs-nnme35pyr-gly-betabmph 644: bhs-25oxaz-gly-betadmph 645: ibhs-25oxaz-bala-betabpy 646: phhs-me24thioph-gly-betadcph ) 647: tolhs-24thioph-bala-betathio3 648: ibhs-25methiaz-bala-psdap 649: bim-25thiaz-gly-psdap 650: ibhs-25methiaz-gly-betahbcph 651: ibhs-ithiadiaz-gly-betacbph 652: ibhs-25methiaz-gly-betabthioph 653: bim-me24thioph-gly-betadcph 654: bhs-oxadiaz-bala-betatos 655: phhs-nme35pyr-gly-betabdimo 656: gua-26py-gly-betahmofu 657: ibhs-24thioph-gly-psdaptb 658: phhs-25oxaz-bala-betainyl 659: phhs-24thiaz-bala-betameph 660: bim-25thioph-bala-zdap 661: tolhs-25oxaz-bala-betahmo 662: tolhs-ithiadiaz-gly-betacbph 663: tolhs-25methiaz-bala-beta34meoph 664: bhs-24im-gly-betameph -44 665: tolhs-oxadiaz-gly-betadcphee 666: phhs-25thiaz-gly-betadmph 667: bhs-nme35pyr-ala-betadmoph 668: ibhs-24thiaz-gly-betafphe 5 669: cima-25oxaz-gly-betameph 670: phhs-25oxaz-gly-betatos 671: phhs-25methiaz-bala-beta3quin 672: bim-24oxaz-ala-zdap 673: ibhs-25methiaz-gly-csdap 0 674: phhs-ithiadiaz-bala-betafph 675: dhim-52thiaz-gly-psdap 676: bhs-24thiaz-ala-zdap 677: ibhs-ithiadiaz-bala-aspibua 678: ibhs-oxadiaz-bala-betahmofu 5 679: phhs-24thioph-bala-betaoxaz 680: phhs-25oxaz-bala-busu2be 681: tolhs-25oxaz-bala-ibsdap 682: ibhs-24thioph-gly-betacph 683: bhs-35thioph-ala-betameph D 684: 2py-25thioph-gly-betainyl 685: bim-nme35pyr-ala-betapy 686: 2py-25thiaz-bala-aspaba 687: bhs-24thioph-gly-betabenfu 688: phhs-nme35pyr-bala-betabph 689: ibhs-oxadiaz-gly-betatos 690: phhs-ithiadiaz-gly-betamesu 691: 2pmhs-25oxaz-bala-betabnaphth 692: tolhs-25methiaz-bala-busu2be 693: tolhs-25oxaz-gly-betapyr ) 694: bhs-ithiadiaz-gly-beta34meoph 695: phhs-24thioph-bala-betampy 696: tolhs-nme35pyr-gly-busu2be 697: bhs-25oxaz-gly-psdap 698: phhs-25oxaz-gly-betaph 699: phhs-me25oxaz-gly-zdap 700: bhs-24thioph-gly-betahc 701: ibhs-25thiaz-gly-beta23meoph -45 702: phhs-25methiaz-gly-betabnaphth 703: phhs-24thioph-gly-betabpy 704: tolhs-25oxaz-bala-betatbuph 705: bhs-24thiaz-gly-zdaptb 5 706: gua-26py-gly-betaph 707: tolhs-me25thiaz-bala-betadcph 708: phhs-24thiaz-bala-betabediox 709: ibhs-25methiaz-gly-betathiobe 710: phhs-24thiaz-gly-beta3quin 0 711: tolhs-25oxaz-gly-betadmph 712: dhpyrr-25thioph-gly-betadcph 713: phhs-ithiadiaz-gly-betahb 714: hts-42nmeim-gly-zdap 715: dhim-24thiaz-gly-zdap 5 716: bhs-24thioph-ser-betapy 717: 2py-25fur-bala-betadcph 718: bhs-42nmeim-bala-betaol 719: bhs-25methiaz-bala-betafphe 720: ibhs-25thiaz-bala-betaipr D 721: 2py-24thiaz-bala-aspaba 722: phhs-me25thiaz-ala-betadcph 723: phhs-oxadiaz-bala-betadmph 724: tolhs-ithiadiaz-bala-betapych 725: phhs-25oxaz-bala-betapych 5 726: tolhs-24thiaz-bala-betadbph 727: ibhs-25methiaz-gly-betabenfu 728: bhs-25methiaz-gly-beta4bph 729: bhs-ithiadiaz-gly-betameph 730: phhs-24thioph-bala-betabenfu 731: bhs-25methiaz-nmgly-ibsdap 732: bhs-oxadiaz-gly-betacbph 733: bhs-nme35pyr-gly-betaftrif 734: phhs-25oxaz-gly-suabu 735: bhs-25methiaz-nmgly-betaanaphth 736: bhs-ithiadiaz-bala-betadbph 737: bim-me25oxaz-gly-betaph 738: phhs-24thioph-gly-betaoxaz -46 739: bhs-42oxaz-gly-zdap 740: bhs-24thiaz-nmgly-betahmph 741: ibhs-ithiadiaz-bala-betapytb 742: bhs-25methiaz-nmgly-betafphe 5 743: bhs-oxadiaz-ala-beta34meoph 744: bim-53pyrazo-ala-zdap 745: phhs-25methiaz-gly-betadcph 746: phhs-24thioph-gly-zdaptb 747: hts-25oxaz-bala-betadcph 0 748: 2py-ithiadiaz-ala-betadcph 749: bim-nme35pyr-gly-betapy 750: phhs-oxadiaz-gly-betatrif 751: ibhs-24thiaz-bala-betabnaphth 752: 2py-25methiaz-gly-beta3quin 5 753: phhs-oxadiaz-bala-betapbiph 754: tolhs-25thiaz-gly-betatrif 755: bim-53pyrazo-gly-betapy 756: bhs-ithiadiaz-nmgly-betabnaphth 757: phhs-25thiaz-gly-betadtrif ) 758: phhs-nme35pyr-gly-psdapch 759: tolhs-25thiaz-bala-betaomebendi 760: phhs-24thiaz-gly-betaoxope 761: ibhs-oxadiaz-gly-betathio3 762: phhs-oxadiaz-gly-betaph 763: phhs-oxadiaz-bala-betabph 764: bim-me25thiaz-bala-betaph 765: ibhs-oxadiaz-bala-beta4bph 766: bim-me25thiaz-leu-zdap 767: 2py-25methiaz-ala-psdap 768: bhs-42oxaz-ala-betadcph 769: bhs-25methiaz-gly-betainyl 770: bim-triaz-gly-betadcph 771: tolhs-24thiaz-bala-betabthioph 772: bhs-nme35pyr-bala-busu2be 773: bhs-25oxaz-nmgly-betainyl 774: phhs-me25thiaz-gly-betapy 775: bhs-ithiadiaz-gly-beta4bph -47 776: phhs-me25thiaz-bala-betadcph 777: bhs-25thiaz-gly-zdap 778: phhs-24thiaz-bala-betah35dc 779: tolhs-nme35pyr-bala-betahmofu 5 780: bhs-24thiaz-bala-betabdimo 781: bim-ithiadiaz-gly-zdap 782: ibhs-24thioph-gly-betadbph 783: bhs-me25oxaz-gly-betapy 784: bhs-24thiaz-ala-beta23meoph 0 785: ibhs-nme35pyr-bala-betapytb 786: bhs-25oxaz-gly-betaamibe 787: bhs-ithiadiaz-gly-betaoxope 788: gua-25thioph-gly-betacthioph 789: bhs-oxadiaz-gly-betapyr 5 790: phhs-me25oxaz-ala-beta34meoph 791: bhs-ithiadiaz-gly-betadmph 792: bim-25methiaz-bala-betaimid 793: ibhs-oxadiaz-bala-betameph 794: ibhs-oxadiaz-bala-betahph 3 795: phhs-24thioph-gly-betathio3 796: tolhs-nme35pyr-bala-betapyr 797: ibhs-ithiadiaz-gly-betamethi 798: phhs-24thiaz-bala-beta3quin 799: ibhs-nme35pyr-gly-betaipro i 800: ibhs-oxadiaz-gly-aspbzla 801: bhs-25thiaz-bala-betamesu 802: bim-35fur-bala-zdap 803: tolhs-nme35pyr-gly-betabph 804: phhs-ithiadiaz-bala-betaphethioa 805: ibhs-nme35pyr-gly-ibsdap 806: bim-24thiaz-leu-betapy 807: thpy-25methiaz-gly-betadcph 808: phhs-24thioph-gly-betabenfu 809: ibhs-25methiaz-gly-betapych 810: ibhs-oxadiaz-gly-betaph 811: bhs-25thiaz-gly-betaftrif 812: phhs-nme35pyr-bala-betapym -48 813: tolhs-25thiaz-gly-betameph 814: 2py-25methiaz-bala-betaheph 815: 2py-25methiaz-gly-aspaba 816: phhs-24thiaz-bala-betapych 5 817: bhs-35fur-bala-betadcph 818: phhs-ithiadiaz-gly-suabu 819: 2py-42pym-gly-zdap 820: ibhs-ithiadiaz-gly-betaimid 821: tolhs-25oxaz-gly-betahdbph 0 822: ibhs-25oxaz-bala-betahbcph 823: ibhs-ithiadiaz-bala-betaoxope 824: tolhs-oxadiaz-gly-ibsdap 825: tolhs-nme35pyr-bala-betabenfu 826: bhs-24thioph-gly-betaphethioa 5 827: bhs-me25thiaz-bala-betadcph 828: tolhs-me24oxaz-bala-betaph 829: phhs-ithiadiaz-bala-betafbph 830: ibhs-24thioph-gly-betabediox 831: tolhs-me25thioph-bala-zdap 832: tolhs-oxadiaz-bala-betapym 833: bhs-25oxaz-gly-zdaptb 834: ibhs-ithiadiaz-bala-betal 3bendi 835: bhs-nme35pyr-bala-betatbuph 836: phhs-oxadiaz-gly-betaphethioa i 837: dhim-thiadiaz-gly-betameph 838: bhs-24thioph-nmgly-betacthioph 839: phhs-25methiaz-bala-betaoxaz 840: ibhs-24thiaz-gly-betaimid 841: phhs-24thioph-bala-betabnaphth 842: bhs-24im-bala-betapy 843: tolhs-24thiaz-gly-betabph 844: 2py-25methiaz-gly-aspbzla 845: 2pmhs-25thiaz-phe-zdap 846: 2pmhs-24thiaz-gly-betahb 847: bhs-24thiaz-gly-betambiph 848: phhs-25oxaz-gly-psdapch 849: ibhs-24thiaz-gly-beta4bph -49 850: bim-ithiadiaz-bala-betadcph 851: tolhs-25thiaz-gly-betahdcph 852: bhs-ithiadiaz-bala-betamethioph 853: ibhs-25oxaz-gly-ibsdap 5 854: ibhs-25oxaz-gly-betabthioph 855: bhs-25methiaz-leu-psdap 856: bhs-25thiaz-bala-betabph 857: tolhs-nme35pyr-bala-betaanaphth 858: bim-me24thioph-leu-betaph 0 859: thpy-42pym-gly-betadcph 860: thpy-25oxaz-bala-zdap 861: ibhs-ithiadiaz-bala-betahmofu 862: ibhs-oxadiaz-gly-betabph 863: bhs-24thiaz-bala-betal 3bendi 5 864: dhim-24oxaz-ala-betainyl 865: tolhs-nme35pyr-gly-betaoxaz 866: tolhs-oxadiaz-gly-betathio3 867: bhs-25fur-gly-zdap 868: bim-24im-ala-psdap ) 869: ibhs-nme35pyr-bala-betabmph 870: bhs-ithiadiaz-ala-betathio3 871: tolhs-25thiaz-gly-beta34meoph 872: tolhs-24thioph-gly-betahmofu 873: phhs-25oxaz-gly-zdap 874: 2pmhs-42nmeim-bala-betabph 875: tolhs-25oxaz-bala-busu2be 876: phhs-ithiadiaz-gly-betathioph 877: bhs-25fur-ala-psdap 878: tolhs-25methiaz-bala-betaphethio 879: phhs-oxadiaz-bala-betathiobe 880: ibhs-24thioph-gly-betaibph 881: tolhs-25thiaz-gly-betadito 882: tolhs-25thiaz-gly-betahc 883: tolhs-24thiaz-bala-betabenfu 884: 2py-25thiaz-bala-aspibua 885: impy-25thiaz-gly-betaipr 886: phhs-ithiadiaz-bala-beta35dbph -50 887: phhs-25thiaz-bala-suabu 888: phhs-24thiaz-bala-betapym 889: dhim-52thiaz-gly-zdap 890: ibhs-24thioph-bala-betathiome 5 891: bim-42nmeim-bala-betadcph 892: tolhs-ithiadiaz-gly-betaoxaz 893: phhs-25thiaz-bala-betamethi 894: phhs-24thiaz-gly-betaphethioa 895: bhs-ithiadiaz-ala-betacthioph 0 896: phhs-nme35pyr-bala-betahbcph 897: phhs-me24thiaz-bala-betadcph 898: hs-25oxaz-gly-betadcph 899: ibhs-25oxaz-gly-beta3quin 900: tolhs-24thioph-bala-betaibph 5 901: tolhs-24thioph-bala-betahb 902: thazep-24thiaz-gly-betapy 903: ibhs-nme35pyr-bala-beta3quin 904: tolhs-25oxaz-bala-betaamibe 905: bhs-oxadiaz-ala-zdap 0 906: tolhs-24thioph-bala-beta4bph 907: phhs-ithiadiaz-bala-betapbiph 908: gua-42pym-gly-betafph 909: phhs-nme35pyr-gly-betatbuph 910: tolhs-nme35pyr-bala-beta34dcph 5 911: phhs-24thiaz-bala-aspibua 912: 2py-25thioph-ala-betameph 913: bim-me25thioph-leu-beta34meoph 914: 2py-me25oxaz-leu-betapy 915: 2py-24thioph-gly-aspibua 916: ibhs-25oxaz-gly-betadcphtb 917: gua-42pym-gly-betadcph 918: bhs-24thiaz-bala-betadcphee 919: tolhs-25oxaz-bala-psdapee 920: tolhs-oxadiaz-bala-betaftrif 921: ibhs-oxadiaz-gly-betatbuph 922: bhs-me24oxaz-ala-betadcph 923: tolhs-ithiadiaz-bala-betafu3 -51 924: ibhs-24thioph-bala-zdaptb 925: phhs-25thiaz-bala-betadbph 926: 2py-42oxaz-leu-zdap 927: bhs-oxadiaz-bala-betahmofu 5 928: ibhs-25methiaz-gly-betathiome 929: phhs-nme35pyr-bala-betadito 930: phhs-24thioph-gly-beta34meoph 931: tolhs-nme35pyr-bala-betainyl 932: phhs-me24thioph-gly-beta34meoph 0 933: bim-me25thiaz-gly-betadcph 934: bhs-24thiaz-ala-csdap 935: phhs-24thioph-gly-aspbzla 936: bim-25thiaz-gly-betatrif 937: impy-24thioph-gly-betacbph 5 938: dhpyrr-25methiaz-gly-betapy 939: bhs-24thiaz-bala-betadmoph 940: bhs-42pym-gly-psdap 941: phhs-ithiadiaz-bala-betapyee 942: phhs-24thioph-bala-betathiobe 943: bim-35thioph-leu-psdap 944: phhs-me24oxaz-leu-betapy 945: phhs-24thioph-bala-betacph 946: ibhs-25methiaz-bala-betatos 947: tolhs-25oxaz-bala-betaoxope 948: gua-24oxaz-gly-betamethioph 949: tolhs-25methiaz-gly-suabu 950: phhs-24thiaz-bala-betamethi 951: phhs-ithiadiaz-gly-betadhbfu 952: gua-24thiaz-gly-betadbph 953: bhs-25methiaz-nmgly-betabnaphth 954: bhs-24thioph-leu-betapy 955: phhs-25thiaz-gly-betacthioph 956: bim-25oxaz-bala-aspaba 957: phhs-ithiadiaz-bala-psdapee 958: tolhs-oxadiaz-bala-busu2be 959: phhs-me24thiaz-bala-betapy 960: phhs-me24thioph-leu-beta34meoph -52 961: phhs-24thioph-gly-betapbiph 962: bhs-ithiadiaz-bala-beta34dcph 963: bim-me24thiaz-ala-betaph 964: bhs-nme35pyr-bala-psdapch 5 965: phhs-24thiaz-bala-betabmph 966: phhs-24thiaz-gly-betadmph 967: bim-triaz-ala-zdap 968: thpym-25oxaz-gly-betameph 969: bim-24thiaz-gly-betaibph 0 970: tolhs-24thiaz-gly-betaheph 971: tolhs-ithiadiaz-gly-zdaptb 972: bim-26pyrazi-gly-zdap 973: ibhs-24thioph-gly-betaol 974: bim-me25thiaz-gly-betaph 5 975: ibhs-25methiaz-bala-betadcphch 976: phhs-24thioph-gly-psdapch 977: phhs-24thioph-gly-betahdbph 978: phhs-me25oxaz-gly-betapy 979: dhim-24thiaz-gly-betadcph 980: bim-me24thiaz-ala-betadcph 981: bhs-nme35pyr-gly-betaomebendi 982: phhs-oxadiaz-bala-psdapee 983: bhs-24thioph-bala-betahc 984: ibhs-24thiaz-bala-betathiobe i 985: bhs-25methiaz-gly-betal 3bendi 986: phhs-oxadiaz-bala-busu2be 987: phhs-ithiadiaz-gly-betafu3 988: phhs-24thioph-gly-betaimid 989: tolhs-25thiaz-bala-beta35dbph 990: bhs-oxadiaz-gly-betacthioph 991: bhs-ithiadiaz-gly-betapych 992: bim-24oxaz-gly-psdap 993: tolhs-me24thiaz-bala-betapy 994: bhs-25oxaz-gly-betathio3 995: bim-oxadiaz-bala-betadcph 996: phhs-nme35pyr-gly-betafu3 997: dhim-25thiaz-ala-betapy -53 998: agua-25methiaz-gly-psdap 999: bim-nme35pyr-leu-zdap 1000: tolhs-24thiaz-bala-betahmo 1001: bim-35fur-bala-psdap 5 1002: bhs-24thiaz-gly-betadmoph 1003: dhim-25methiaz-gly-betapy 1004: phhs-25methiaz-gly-betapytb 1005: 2 py-me25oxaz-leu-beta34meoph 1006: gua-24thiaz-gly-betapym 0 1007: bim-35fur-leu-zdap 1008: bhs-25thioph-leu-betadcph 1009: ibhs-25thiaz-bala-betameph 1010: bhs-24thioph-gly-psdap 1011: 2py-35fur-gly-psdap 5 1012: ibhs-oxadiaz-bala-busu2be 1013: ibhs-oxadiaz-bala-zdap 1014: bhs-25methiaz-gly-betahb 1015: tolhs-25oxaz-bala-beta4bph 1016: phhs-me24oxaz-bala-beta34meoph D 1017: tolhs-25oxaz-gly-beta4bph 1018: bim-35thioph-gly-betadcph 1019: bhs-25oxaz-bala-beta3quin 1020: impy-25thiaz-gly-betabediox 1021: bhs-nme35pyr-bala-betabmph 5 1022: phhs-me24oxaz-gly-beta34meoph 1023: tolhs-24thioph-bala-betaipr 1024: 2py-me25thioph-leu-betadcph 1025: ibhs-24thiaz-bala-betaol 1026: ibhs-24thioph-gly-betatos 1027: phhs-25thiaz-gly-betahni 1028: tolhs-24thioph-bala-betamethi 1029: tolhs-24thiaz-gly-betafu2 1030: ibhs-ithiadiaz-gly-betathioph 1031: 2py-42nmeim-ala-betadcph 1032: phhs-24thioph-bala-aspibua 1033: 2py-25thiaz-gly-zdap 1034: bhs-25thiaz-gly-psdapch -54 1035: gua-42pym-gly-betadito 1036: ibhs-25oxaz-gly-betahdcph 1037: tolhs-oxadiaz-bala-betathiome 1038: phhs-25thiaz-bala-betaftrif 5 1039: phhs-ithiadiaz-bala-betabdimo 1040: bhs-nme35pyr-ala-betal 3bendi 1041: ibhs-25methiaz-gly-betadtrif 1042: dhim-25thiaz-gly-betainyl 1043: bim-24thiaz-bala-betapy 0 1044: bhs-25thiaz-nmgly-betathioph 1045: bhs-25thiaz-gly-betatbuph 1046: tolhs-ithiadiaz-gly-aspibua 1047: phhs-ithiadiaz-bala-ibsdap 1048: bhs-24thiaz-bala-zdaptb 5 1049: ibhs-25methiaz-gly-busu2be 1050: tolhs-oxadiaz-bala-betahmph 1051: phhs-ithiadiaz-gly-csdap 1052: impy-24thioph-bala-psdap 1053: bim-me25thiaz-leu-psdap D 1054: phhs-ithiadiaz-gly-ibsdap 1055: bhs-25methiaz-gly-betah35dc 1056: bhs-25thiaz-met-betameph 1057: tolhs-25methiaz-bala-betainyl 1058: phhs-25thiaz-gly-beta23meoph 5 1059: phhs-24thioph-gly-betafu2 1060: phhs-me24oxaz-gly-betadcph 1061: tolhs-25thiaz-bala-betah35dc 1062: bhs-24thioph-bala-psdapch 1063: bhs-me24thioph-gly-beta34meoph 1064: tolhs-me24thiaz-ala-betaph 1065: phhs-25methiaz-bala-betaibph 1066: ibhs-ithiadiaz-gly-betadcph 1067: phhs-24thiaz-gly-aspbzla 1068: tolhs-25methiaz-bala-betabdimo 1069: bhs-24thioph-ala-betadmph 1070: gua-42pym-gly-betahcbph 1071: ibhs-25oxaz-bala-betamesu -55 1072: ibhs-25thiaz-bala-betahcbph 1073: bhs-24thiaz-gly-betabediox 1074: bhs-24thiaz-ala-betamesu 1075: gua-42pym-gly-betaet 5 1076: bhs-oxadiaz-bala-betathiome 1077: ibhs-25thiaz-gly-betahb 1078: tolhs-ithiadiaz-bala-betadcphtb 1079: bhs-24thiaz-bala-betaoxaz 1080: bhs-24thioph-gly-zdap 0 1081: bim-nme35pyr-bala-betapy 1082: ibhs-ithiadiaz-gly-beta23meoph 1083: bhs-25thiaz-ala-beta34meoph 1084: tolhs-me25thioph-bala-betadcph 1085: bhs-ithiadiaz-bala-betaol 5 1086: phhs-24thiaz-gly-betacbph 1087: phhs-25methiaz-bala-betabenfu 1088: bim-nme35pyr-leu-betapy 1089: 2py-35fur-leu-zdap 1090: ibhs-24thioph-gly-betabpy 0 1091: tolhs-25thiaz-bala-betathiome 1092: phhs-24thioph-bala-busu2be 1093: tolhs-oxadiaz-gly-betaphethio 1094: dhim-26py-ala-betathioph 1095: phhs-nme35pyr-gly-beta34dcph 5 1096: ibhs-25oxaz-bala-beta23meoph 1097: bhs-25thiaz-ala-zdap 1098: dhthi-24thiaz-bala-betadcph 1099: bhs-nme35pyr-bala-betaoxaz 1100: ibhs-25methiaz-bala-betapytb 1101: ibhs-nme35pyr-gly-betapytb 1102: tolhs-24thiaz-bala-betamesu 1103: bhs-24thioph-gly-betafu3 1104: tolhs-oxadiaz-gly-betabenfu 1105: tolhs-nme35pyr-gly-betafbph 1106: bim-ithiadiaz-bala-zdap 1107: gua-25thioph-gly-suabu 1108: bhs-oxadiaz-gly-betathiobe -56 1109: phhs-25oxaz-gly-betafluo 1110: 2py-me25oxaz-leu-psdap 1111: ibhs-25oxaz-bala-betahni 1112: ibhs-oxadiaz-gly-betaol 5 1113: tolhs-25thiaz-gly-betaftrif 1114: tolhs-25oxaz-bala-betabdimo 1115: tolhs-25oxaz-gly-asppha 1116: bhs-me24thiaz-ala-betaph 1117: tolhs-24thiaz-gly-betafbph 0 1118: 2py-oxadiaz-gly-psdap 1119: bhs-25thiaz-bala-betahb 1120: bim-35fur-leu-psdap 1121: bhs-ithiadiaz-nmgly-ibsdap 1122: bhs-24oxaz-ala-betameph 5 1123: bhs-nme35pyr-bala-betapyr 1124: bhs-nme35pyr-ala-betapy 1125: tolhs-24thioph-gly-betaftrif 1126: phhs-25oxaz-gly-betaphethioa 1127: tolhs-nme35pyr-gly-csdap ) 1128: 2py-25fur-bala-zdap 1129: 2py-24oxaz-leu-psdap 1130: tolhs-24thiaz-bala-zdapch 1131: phhs-oxadiaz-gly-betaoxope 1132: ibhs-24thiaz-bala-betapym 1133: thpym-24thiaz-gly-beta35dbph 1134: phhs-ithiadiaz-bala-betadmph 1135: phhs-me25thiaz-leu-betaph 1136: phhs-nme35pyr-bala-betadcphch 1137: 2py-me24thiaz-bala-betaph 1138: phhs-me24thioph-ala-betapy 1139: ibhs-25thiaz-bala-csdap 1140: tolhs-oxadiaz-bala-betaamibe 1141: ibhs-nme35pyr-gly-betabenfu 1142: bhs-25thiaz-gly-betainy 1143: bhs-25thiaz-gly-betahdcph 1144: phhs-25thiaz-gly-betacph 1145: phhs-oxadiaz-gly-betafph -57 1146: phhs-25oxaz-gly-betapym 1147: tolhs-24thiaz-bala-betacph 1148: 2py-me24thioph-ala-betaph 1149: ibhs-24thiaz-bala-betaipro 5 1150: hyd-25thiaz-bala-betameph 1151: bim-52thiaz-ala-betapy 1152: bim-me25thiaz-ala-beta34meoph 1153: bhs-oxadiaz-bala-betabmph 1154: dhim-24thiaz-ala-psdap 0 1155: ibhs-24thioph-bala-zdapee 1156: gua-25thiaz-gly-betahbcph 1157: bhs-ithiadiaz-bala-betabthioph 1158: tolhs-24thiaz-bala-betal 3bendi 1159: bim-me24oxaz-ala-beta34meoph 5 1160: bim-me25oxaz-gly-betapy 1161: 2py-25methiaz-gly-aspibua 1162: bim-25thiaz-leu-betapy 1163: bhs-25thiaz-gly-betah35dc 1164: tolhs-25thiaz-bala-betafbph D 1165: bhs-24thioph-bala-csdap 1166: dhim-25thiaz-gly-betahdcph 1167: bhs-25oxaz-nmgly-betacthioph 1168: tolhs-24thiaz-gly-betadcphtb 1169: 2py-25methiaz-bala-psdap 5 1170: bim-ithiadiaz-gly-betadcph 1171: bim-25fur-gly-psdap 1172: tolhs-ithiadiaz-gly-psdapch 1173: bhs-53pyrazo-gly-betadcph 1174: ibhs-oxadiaz-bala-betahb 1175: bhs-nme35pyr-gly-betaanaphth 1176: phhs-25thiaz-bala-psdapch 1177: tolhs-oxadiaz-bala-betahmo 1178: tolhs-25methiaz-bala-betathio3 1179: bim-25oxaz-ala-psdap 1180: bim-42nmeim-gly-betapy 1181: ibhs-nme35pyr-bala-betah35dc 1182: tolhs-24thioph-gly-betabthioph -58 1183: tolhs-25methiaz-bala-betadito 1184: thpym-25thiaz-bala-psdap 1185: bhs-25oxaz-gly-zdap 1186: bhs-25thiaz-phe-betameph 5 1187: bhs-25methiaz-gly-betathiobe 1188: bhs-nme35pyr-bala-betameph 1189: phhs-ithiadiaz-gly-betaoxope 1190: tolhs-24thiaz-gly-betabpy 1191: phhs-ithiadiaz-bala-psdap 0 1192: bgua-42nmeim-gly-betadcph 1193: dhim-24oxaz-gly-betamyl 1194: impy-25oxaz-gly-betampy 1195: bhs-25methiaz-bala-betadmoph 1196: gua-24thiaz-gly-betadito 5 1197: ibhs-ithiadiaz-gly-busu2be 1198: bhs-oxadiaz-bala-betadito 1199: ibhs-24thiaz-bala-betaphethioa 1200: ibhs-ithiadiaz-bala-betatrif 1201: bhs-24thioph-ala-psdap 1202: ibhs-nme35pyr-bala-betahdbph 1203: bhs-24thioph-bala-psdap 1204: 2py-25thiaz-gly-betatbuph 1205: ibhs-24thioph-bala-beta3quin 1206: ibhs-ithiadiaz-bala-betaoxaz 1207: bhs-me24oxaz-gly-zdap 1208: gua-24thiaz-gly-betah35dc 1209: ibhs-24thioph-gly-betatrif 1210: tolhs-25methiaz-gly-betambiph 1211: thpym-26py-gly-betadcph 1212: phhs-24thioph-bala-betahmph 1213: ibhs-25methiaz-bala-betadmph 1214: tolhs-24thioph-gly-betafphe 1215: tolhs-25oxaz-bala-betabnaphth 1216: bhs-24thioph-gly-betaoxope 1217: pahs-26py-gly-betapy 1218: 2py-24im-gly-betadcph 1219: tolhs-nme35pyr-bala-betapytb -59 1220: phhs-nme35pyr-gly-betapyee 1221: bhs-25thiaz-bala-betabmph 1222: gua-42pym-gly-betadmoph 1223: ibhs-nme35pyr-bala-betathiome 5 1224: ibhs-25methiaz-gly-betainyl 1225: bhs-24thiaz-gly-betahcbph 1226: ibhs-24thiaz-bala-psdap 1227: bhs-triaz-ala-zdap 1228: dhim-24thiaz-ala-betameph 0 1229: ibhs-24thiaz-bala-betapych 1230: ibhs-25methiaz-gly-betaoxope 1231: tolhs-24thiaz-bala-betahbcph 1232: tolhs-24thioph-gly-betathio3 1233: tolhs-oxadiaz-gly-betapych 5 1234: tolhs-24thiaz-bala-betatbuph 1235: 2py-25oxaz-leu-betadcph 1236: ibhs-24thiaz-gly-betadito 1237: tolhs-25thiaz-bala-betacthioph 1238: phhs-24thiaz-bala-betaimid 1239: ibhs-25methiaz-gly-betabnaphth 1240: dhim-24oxaz-ala-betameph 1241: phhs-oxadiaz-gly-beta34meoph 1242: 2py-oxadiaz-bala-asppha 1243: phhs-nme35pyr-gly-aspibua 1244: ibhs-nme35pyr-gly-betal 3bendi 1245: bhs-oxadiaz-gly-betahb 1246: tolhs-24thioph-gly-beta4bph 1247: ibhs-25oxaz-bala-betah35dc 1248: ibhs-25thiaz-gly-betaoxope 1249: thpym-25thioph-gly-betahcbph 1250: tolhs-25oxaz-bala-betahmofu 1251: bhs-42pym-ala-psdap 1252: bhs-24thiaz-nmgly-betaipro 1253: ibhs-nme35pyr-gly-betahmofu 1254: phhs-ithiadiaz-gly-betapym 1255: ibhs-24thioph-bala-betahbcph 1256: tolhs-oxadiaz-bala-betadcphch -60 1257: phhs-24thioph-bala-betabmph 1258: phhs-25oxaz-bala-betaftrif 1259: 2py-thiadiaz-ala-betadcph 1260: phhs-me25thiaz-leu-psdap 5 1261: phhs-nme35pyr-gly-betapych 1262: bhs-oxadiaz-bala-betafu3 1263: 2pmhs-42nmeim-bala-betameph 1264: ibhs-oxadiaz-bala-betabmph 1265: ibhs-25thiaz-bala-beta23meoph 0 1266: gua-25thiaz-gly-betaph 1267: bhs-24thiaz-ser-betapy 1268: bhs-24thiaz-met-betadcph 1269: bhs-ithiadiaz-gly-betacthioph 1270: bhs-42pym-gly-betainyl 5 1271: 2py-triaz-bala-zdap 1272: 2py-me24oxaz-ala-zdap 1273: phhs-24thioph-bala-betahc 1274: tolhs-24thioph-bala-psdapch 1275: phhs-oxadiaz-gly-betainyl 0 1276: bhs-25thiaz-nmgly-betamesu 1277: ibhs-24thioph-bala-beta34dcph 1278: phhs-nme35pyr-bala-betameph 1279: phhs-24thioph-bala-betaamibe 1280: 2py-oxadiaz-leu-psdap 5 1281: bim-25thiaz-ala-betadcph 1282: bim-35thioph-gly-zdap 1283: bim-35py-gly-zdap 1284: ibhs-25oxaz-bala-betapyee 1285: tolhs-me24thiaz-bala-zdap 1286: tolhs-25thiaz-bala-betadito 1287: phhs-oxadiaz-gly-betadtrif 1288: bhs-24thioph-gly-betathiobe 1289: bhs-25thiaz-gly-betaphethioa 1290: tolhs-25oxaz-gly-betahc 1291: bhs-25oxaz-gly-betaimid 1292: tolhs-oxadiaz-bala-betaipr 1293: phhs-24thiaz-gly-betapyr -61 1294: bhs-me25thioph-gly-betadcph 1295: phhs-nme35pyr-bala-betadmoph 1296: phhs-24thioph-bala-betabpy 1297: phhs-24thioph-bala-beta23meoph 5 1298: phhs-24thiaz-bala-zdapch 1299: bhs-42oxaz-bala-zdap 1300: ibhs-ithiadiaz-bala-betadcphee 1301: phhs-nme35pyr-bala-betambiph 1302: bim-42nmeim-bala-betacbph 0 1303: tolhs-25thiaz-bala-beta34dcph 1304: hs-25methiaz-bala-betapy 1305: dhim-42pym-gly-betapy 1306: bhs-42oxaz-leu-betapy 1307: bhs-24thiaz-nmgly-betadmph 5 1308: dhim-25thiaz-ala-psdap 1309: phhs-25oxaz-bala-betamethi 1310: phhs-me24thiaz-ala-betaph 1311: ibhs-24thioph-gly-betameph 1312: gua-24oxaz-gly-betaheph 0 1313: bhs-ithiadiaz-gly-betal 3bendi 1314: bhs-ithiadiaz-bala-betahcbph 1315: bhs-nme35pyr-gly-betaheph 1316: bhs-25thiaz-leu-psdap 1317: tolhs-25oxaz-bala-betadmoph 5 1318: bim-25thiophme-gly-zdap 1319: bhs-nme35pyr-nmgly-betabnaphth 1320: 2py-24thioph-bala-betahni 1321: phhs-oxadiaz-bala-psdapch 1322: ibhs-25thiaz-bala-betabediox 1323: tolhs-25oxaz-gly-betafphe 1324: ibhs-25methiaz-bala-beta4bph 1325: tolhs-25thiaz-gly-betadbph 1326: dhim-26py-gly-zdap 1327: ibhs-24thioph-gly-betacthioph 1328: 2py-ithiadiaz-gly-psdap 1329: tolhs-me25oxaz-ala-betaph 1330: ibhs-nme35pyr-gly-betamethioph -62 1331: bhs-ithiadiaz-bala-betabpy 1332: bhs-oxadiaz-bala-betabph 1333: ibhs-oxadiaz-gly-betampy 1334: dhthi-26py-gly-betapy 5 1335: bhs-25thiaz-gly-betadmph 1336: bim-25methiaz-gly-betaomebendi 1337: tolhs-25thiaz-bala-betadhbfu 1338: bhs-oxadiaz-nmgly-beta34meoph 1339: bim-nme35pyr-bala-asppha 0 1340: 2py-42nmeim-gly-betafphe 1341: bhs-35thioph-gly-psdap 1342: 2py-42nmeim-bala-betaanaphth 1343: phhs-25thiaz-gly-psdapch 1344: bhs-25methiaz-bala-betabdimo 5 1345: tolhs-me24oxaz-gly-betaph 1346: ibhs-24thioph-bala-betadito 1347: bhs-24thioph-nmgly-betabnaphth 1348: bhs-oxadiaz-bala-betadcphtb 1349: bhs-26py-ala-psdap D 1350: bhs-24thioph-nmgly-betamesu 1351: tolhs-oxadiaz-bala-betaimid 1352: bhs-ithiadiaz-nmgly-betadito 1353: phhs-25methiaz-bala-zdapee 1354: bhs-ithiadiaz-bala-betaphethioa 5 1355: impy-24thioph-gly-betambiph 1356: bhs-ithiadiaz-gly-betafu2 1357: bhs-ithiadiaz-nmgly-betathioph 1358: phhs-25oxaz-bala-suabu 1359: bhs-25methiaz-bala-betacbph 1360: phhs-me24oxaz-bala-betadcph 1361: dhim-25thiaz-gly-betadtrif 1362: bhs-24thioph-bala-betathiome 1363: phhs-25oxaz-gly-beta34dcph 1364: tolhs-me25oxaz-bala-betadcph 1365: ibhs-25thiaz-gly-betaamibe 1366: bhs-nme35pyr-nmgly-beta23meoph 1367: 2py-24thiaz-gly-aspaba -63 1368: gua-24thioph-bala-betadcph 1369: tolhs-24thioph-gly-betamethioph 1370: gua-24thiaz-gly-betaph 1371: 2py-25methiaz-bala-aspibua 5 1372: ibhs-25oxaz-gly-zdaptb 1373: phhs-me25thiaz-leu-betadcph 1374: bhs-nme35pyr-bala-psdaptb 1375: bhs-25methiaz-gly-betahcbph 1376: ibhs-25methiaz-gly-betah35dc 0 1377: bhs-24thiaz-bala-aspaba 1378: tolhs-ithiadiaz-bala-betal 3bendi 1379: bhs-ithiadiaz-bala-betaph 1380: tolhs-oxadiaz-gly-betaoxope 1381: 2py-thiadiaz-gly-betapy 5 1382: phhs-24thiaz-bala-betaphethioa 1383: gua-24thiaz-gly-beta35dbph 1384: bim-26py-gly-betainyl 1385: pahs-25thiaz-bala-betameph 1386: bim-thiadiaz-ala-psdap 0 1387: bhs-me24thiaz-leu-beta34meoph 1388: phhs-25oxaz-gly-betambiph 1389: phhs-oxadiaz-gly-betaomebendi 1390: phhs-25oxaz-bala-betamethioph 1391: dhim-24thiaz-gly-betapy 5 1392: bim-24thioph-nmala-betadcph 1393: bhs-nme35pyr-gly-betampy 1394: 2py-me24oxaz-bala-betapy 1395: 2py-25thioph-gly-zdap 1396: ibhs-24thioph-bala-betah35dc 1397: phhs-me25thioph-gly-betadcph 1398: bhs-24thioph-bala-betapym 1399: tolhs-24thioph-gly-aspbzla 1400: ibhs-25thiaz-bala-betapyee 1401: tolhs-nme35pyr-gly-betapyee 1402: bhs-25oxaz-gly-betahdcph 1403: bhs-25oxaz-gly-beta4bph 1404: ibhs-24thiaz-bala-beta4bph -64 1405: bim-ithiadiaz-bala-betapy 1406: ibhs-nme35pyr-bala-betabdimo 1407: 2py-25thiaz-gly-aspibua 1408: bhs-25oxaz-ala-betabpy 5 1409: bhs-oxadiaz-gly-betahbcph 1410: bim-me25thioph-leu-betaph 1411: bhs-24thiaz-bala-betadito 1412: dhim-24oxaz-gly-betadcph 1413: tolhs-ithiadiaz-gly-betahcbph 0 1414: bhs-nme35pyr-leu-betapy 1415: tolhs-nme35pyr-bala-betaol 1416: ibhs-oxadiaz-gly-betapych 1417: tolhs-nme35pyr-gly-betacthioph 1418: tolhs-nme35pyr-bala-aspbzla 5 1419: 2py-me24thioph-gly-beta34meoph 1420: dhpyrr-24thiaz-gly-betadcph 1421: bhs-24thiaz-gly-betaet 1422: bim-24thiaz-nmala-betadcph 1423: ibhs-nme35pyr-gly-betambiph 0 1424: tolhs-ithiadiaz-gly-ibsdap 1425: tolhs-25oxaz-gly-betacthioph 1426: tolhs-24thioph-gly-betadhbfu 1427: bhs-me25thiaz-ala-betaph 1428: phhs-25thiaz-bala-betameph 5 1429: bhs-24thiaz-ala-beta34dcph 1430: ibhs-nme35pyr-bala-betapyr 1431: 2py-me24thioph-leu-betapy 1432: bhs-24thiaz-bala-betafu2 1433: bhs-ithiadiaz-bala-betaamibe 1434: bhs-25methiaz-ala-betadmoph 1435: bim-me24thiaz-gly-zdap 1436: bim-25methiaz-bala-csdap 1437: 2py-me25oxaz-ala-beta34meoph 1438: phhs-oxadiaz-gly-ibsdap 1439: phhs-25thiaz-bala-betabph 1440: bhs-25methiaz-ala-beta34dcph 1441: tolhs-oxadiaz-bala-betapyee -65 1442: ibhs-oxadiaz-bala-betaanaphth 1443: tolhs-25oxaz-bala-betathiobe 1444: 2pmhs-24thiaz-bala-beta4bph 1445: ibhs-ithiadiaz-gly-ibsdap 5 1446: phhs-24thioph-bala-aspaba 1447: tolhs-24thiaz-bala-betaamibe 1448: bhs-25methiaz-gly-betaanaphth 1449: bhs-24thioph-gly-betaph 1450: bhs-oxadiaz-bala-betahb 0 1451: bhs-52thiaz-gly-betapy 1452: ibhs-oxadiaz-bala-betafluo 1453: phhs-nme35pyr-bala-betadtrif 1454: phhs-25oxaz-bala-betapyr 1455: bhs-25methiaz-bala-betaipr 5 1456: ibhs-24thiaz-gly-beta35dbph 1457: ibhs-25thiaz-gly-psdapch 1458: bhs-24thiaz-bala-betatbuph 1459: tolhs-ithiadiaz-bala-betadmoph 1460: ibhs-25thiaz-gly-betaftrif D 1461: bhs-25methiaz-ala-betafphe 1462: sabhs-42pym-gly-betapy 1463: phhs-me25thiaz-bala-zdap 1464: phhs-24thiaz-gly-betaibph 1465: 2py-25methiaz-gly-betacthioph 5 1466: dhim-25thioph-gly-betapy 1467: bim-me24thiaz-bala-psdap 1468: ibhs-24thioph-gly-betabnaphth 1469: tolhs-25methiaz-bala-betaoxope 1470: sabhs-25oxaz-bala-betameph 1471: tolhs-25methiaz-gly-beta34dcph 1472: ibhs-oxadiaz-bala-betathiome 1473: dhim-42pym-gly-betahdcph 1474: 2py-25thiaz-leu-betapy 1475: ibhs-25thiaz-gly-betah35dc 1476: bhs-25oxaz-bala-betathiobe 1477: bhs-oxadiaz-nmgly-betamesu 1478: bhs-oxadiaz-bala-betaol -66 1479: phhs-oxadiaz-gly-aspbzla 1480: hs-25thiaz-gly-betapy 1481: tolhs-ithiadiaz-bala-betaomebendi 1482: tolhs-25methiaz-bala-beta4bph 5 1483: phhs-ithiadiaz-bala-csdap 1484: bim-25py-gly-zdap 1485: ibhs-24thioph-gly-betafbph 1486: impy-25methiaz-gly-betambiph 1487: 2pmhs-25thiaz-bala-betamethioph 0 1488: tolhs-24thioph-bala-betafluo 1489: ibhs-ithiadiaz-gly-aspaba 1490: phhs-25methiaz-bala-betacph 1491: bhs-nme35pyr-gly-betatos 1492: dimethpym-25thiaz-gly-betadcph 5 1493: ibhs-oxadiaz-bala-betaimid 1494: tolhs-24thioph-bala-betaoxope 1495: bhs-nme35pyr-bala-betamethioph 1496: 2py-me24thiaz-leu-betaph 1497: tolhs-nme35pyr-bala-betahni ) 1498: phhs-oxadiaz-gly-betacthioph 1499: bhs-25thiaz-gly-busu2be 1500: ibhs-oxadiaz-bala-betaipro 1501: tolhs-25thiaz-bala-betadmoph 1502: bhs-25methiaz-ala-betainyl i 1503: bhs-25oxaz-bala-betahcbph 1504: ibhs-ithiadiaz-gly-betacthioph 1505: tolhs-nme35pyr-bala-betaomebendi 1506: phhs-24thioph-bala-betaipr 1507: tolhs-25methiaz-gly-betaoxaz 1508: tolhs-nme35pyr-bala-betaamibe 1509: bhs-25thiaz-bala-betaheph 1510: ibhs-24thioph-gly-asppha 1511: phhs-oxadiaz-bala-betadmoph 1512: 2py-25thiaz-ala-betameph 1513: bhs-thiadiaz-ala-zdap 1514: bhs-24thiaz-bala-betafph 1515: 2pmhs-25thiaz-bala-betabmph -67 1516: bhs-24thioph-bala-betafu2 1517: bim-me25thioph-bala-zdap 1518: bhs-25methiaz-gly-aspibua 1519: bhs-nme35pyr-nmgly-beta34dcph 5 1520: gua-24thiaz-gly-betafu2 1521: phhs-oxadiaz-gly-betambiph 1522: bhs-24thioph-bala-aspaba 1523: phhs-24thiaz-gly-beta35dbph 1524: ibhs-24thioph-gly-betaipro 0 1525: bhs-ithiadiaz-bala-psdapch 1526: bhs-25oxaz-gly-betamethioph 1527: bhs-25thiaz-ala-beta34dcph 1528: bhs-ithiadiaz-bala-betaipro 1529: bhs-25oxaz-gly-betah35dc 5 1530: gua-25thioph-gly-betah35dc 1531: bhs-25oxaz-gly-betabph 1532: bhs-oxadiaz-bala-betaphethio 1533: impy-24thiaz-bala-psdap 1534: bhs-25methiaz-gly-betaol 3 1535: phhs-25oxaz-bala-betapytb 1536: tolhs-25oxaz-bala-zdaptb 1537: tolhs-nme35pyr-bala-betadcphee 1538: bgua-25thioph-gly-betameph 1539: bhs-oxadiaz-gly-betathio3 5 1540: ibhs-25thiaz-gly-betahc 1541: gua-24thiaz-gly-betathioph 1542: 2py-53pyrazo-bala-betapy 1543: phhs-ithiadiaz-gly-beta34dcph 1544: dhim-25thioph-ala-betadcph 1545: phhs-25thiaz-gly-betapy 1546: ibhs-25thiaz-bala-betah35dc 1547: phhs-25methiaz-gly-psdap 1548: bhs-oxadiaz-gly-betafluo 1549: impy-25thiaz-gly-betacbph 1550: 2py-24im-bala-zdap 1551: tolhs-oxadiaz-bala-betahb 1552: phhs-25oxaz-bala-betaoxope -68 1553: tolhs-25thiaz-gly-betaipr 1554: ibhs-oxadiaz-bala-csdap 1555: ibhs-24thiaz-gly-betampy 1556: bim-thiadiaz-gly-betadcph 5 1557: 2py-me24thioph-bala-betadcph 1558: bhs-ithiadiaz-nmgly-betadhbfu 1559: phhs-25oxaz-bala-betathioph 1560: ibhs-25oxaz-bala-betaol 1561: bhs-nme35pyr-gly-betaoxope 0 1562: phhs-ithiadiaz-bala-betathiobe 1563: 2py-25methiaz-leu-zdap 1564: tolhs-25thiaz-gly-betafu2 1565: phhs-24thioph-bala-betahni 1566: ibhs-nme35pyr-gly-betatbuph 5 1567: ibhs-ithiadiaz-gly-betapbiph 1568: tolhs-oxadiaz-gly-betatos 1569: bim-triaz-bala-betapy 1570: tolhs-25oxaz-bala-betafphe 1571: bhs-ithiadiaz-nmgly-betathio3 ) 1572: 2py-me25thioph-gly-zdap 1573: tolhs-25oxaz-gly-csdap 1574: 2py-thiadiaz-gly-psdap 1575: bhs-52thiaz-gly-betainyl 1576: phhs-ithiadiaz-gly-betahmo 5 1577: ibhs-25thiaz-gly-betathiome 1578: 2py-oxadiaz-bala-betapy 1579: 2pmhs-24thiaz-bala-betathioph 1580: bim-25thiaz-bala-betahc 1581: bim-triaz-leu-psdap 1582: phhs-25methiaz-bala-aspibua 1583: bhs-me24thioph-bala-beta34meoph 1584: phhs-25oxaz-gly-betadcphtb 1585: tolhs-ithiadiaz-gly-beta4bph 1586: ibhs-25oxaz-bala-betamethioph 1587: phhs-ithiadiaz-gly-betah35dc 1588: bhs-25methiaz-gly-betahdbph 1589: gua-25thiaz-gly-betahdbph -69 1590: 4pmhs-24thiaz-bala-betameph 1591: bhs-ithiadiaz-gly-betainyl 1592: tolhs-25oxaz-bala-betah35dc 1593: 2py-25fur-bala-psdap 5 1594: nmhs-24thiaz-gly-psdap 1595: phhs-25methiaz-bala-betadcphee 1596: ibhs-25methiaz-bala-betabph 1597: ibhs-oxadiaz-bala-betabph 1598: ibhs-ithiadiaz-bala-betahbcph 0 1599: 2py-triaz-ala-zdap 1600: bhs-nme35pyr-nmgly-beta3quin 1601: dhim-25thioph-ala-zdap 1602: bhs-me24oxaz-leu-beta34meoph 1603: phhs-25methiaz-gly-aspaba 5 1604: bhs-nme35pyr-bala-betadtrif 1605: tolhs-24thioph-bala-betadtrif 1606: bhs-25methiaz-bala-betahb 1607: 2py-24thiaz-ala-betainyl 1608: bhs-25thiaz-gly-betaph 3 1609: tolhs-oxadiaz-bala-betabediox 1610: bhs-oxadiaz-bala-betaoxope 1611: bhs-25thiaz-nmgly-betaanaphth 1612: phhs-24thioph-gly-betadmph 1613: phhs-25methiaz-gly-betainyl 1614: gua-24thiaz-gly-betadcph 1615: bhs-24thioph-bala-betadcphee 1616: phhs-ithiadiaz-gly-betabph 1617: bhs-thiadiaz-ala-betapy 1618: bim-me25oxaz-leu-psdap 1619: 2py-me24thioph-bala-betaph 1620: tolhs-nme35pyr-bala-betabediox 1621: bhs-25methiaz-ala-beta34meoph 1622: tolhs-ithiadiaz-gly-betadmoph 1623: bhs-24thiaz-nmala-betapy 1624: 2py-triaz-leu-betadcph 1625: ibhs-24thioph-bala-betaibph 1626: phhs-me25oxaz-ala-betaph -70 1627: gua-24oxaz-gly-betaph 1628: phhs-ithiadiaz-gly-betapych 1629: bhs-me24oxaz-leu-zdap 1630: ibhs-25thiaz-bala-betamethi 5 1631: bim-42oxaz-leu-psdap 1632: bhs-25thiaz-hphe-betameph 1633: bhs-nme35pyr-nmgly-betabpy 1634: 2pmhs-25thiaz-bala-betal 3bendi 1635: ibhs-ithiadiaz-gly-zdapch 0 1636: tolhs-oxadiaz-gly-psdapee 1637: bhs-25oxaz-ala-betainyl 1638: tolhs-25thiaz-bala-suabu 1639: bim-24thiaz-leu-betadcph 1640: bhs-24thioph-gly-beta34dcph 5 1641: tolhs-oxadiaz-gly-aspaba 1642: phhs-25thiaz-gly-betathiome 1643: phhs-24thioph-bala-psdaptb 1644: phhs-nme35pyr-bala-betabediox 1645: tolhs-oxadiaz-gly-betahcbph ) 1646: bhs-ithiadiaz-bala-betaomebendi 1647: phhs-24thioph-bala-betahph 1648: 2py-me25thioph-ala-psdap 1649: 2py-24thiaz-leu-betapy 1650: 2py-25oxaz-gly-aspibua i 1651: sabhs-24thiaz-gly-betapy 1652: phhs-25oxaz-gly-betahbcph 1653: tolhs-25methiaz-bala-betabph 1654: bhs-ithiadiaz-bala-aspibua 1655: dhim-26py-gly-betaoxaz 1656: ibhs-oxadiaz-gly-beta4bph 1657: bhs-24thiaz-nmgly-beta3quin 1658: phhs-25methiaz-gly-betabph 1659: tolhs-25methiaz-gly-betathiobe 1660: bhs-25thiaz-bala-zdapee 1661: bim-24thiaz-bala-zdap 1662: 2pmhs-42nmeim-ser-psdap 1663: phhs-24thiaz-gly-betathio3 -71 1664: bhs-24thioph-nmgly-betal3bendi 1665: phhs-25methiaz-gly-betaheph 1666: tolhs-25thiaz-gly-betaet 1667: tolhs-me24thioph-ala-betadcph 5 1668: ibhs-25oxaz-bala-betaipr 1669: phhs-me25thioph-ala-zdap 1670: ibhs-25thiaz-bala-betambiph 1671: tolhs-me25thioph-ala-beta34meoph 1672: ibhs-25thiaz-gly-betaphethio 0 1673: phhs-24thiaz-bala-betaomebendi 1674: ibhs-24thiaz-gly-beta34meoph 1675: bim-35fur-bala-betapy 1676: tolhs-25thiaz-gly-zdapee 1677: ibhs-25oxaz-gly-betatrif 5 1678: phhs-oxadiaz-gly-betamethioph 1679: 2py-thiadiaz-bala-zdap 1680: bhs-24thioph-bala-zdapch 1681: bhs-25methiaz-bala-betafu2 1682: ibhs-oxadiaz-gly-psdap 0 1683: bhs-oxadiaz-gly-betapyee 1684: bhs-me24thioph-gly-zdap 1685: bim-me25oxaz-ala-zdap 1686: bhs-25methiaz-gly-betaomebendi 1687: tolhs-25thiaz-bala-betahb 5 1688: 2py-24thioph-bala-beta34dcph 1689: ibhs-oxadiaz-bala-betapych 1690: ibhs-24thioph-gly-betafu2 1691: bhs-25oxaz-ala-beta3quin 1692: bhs-24thioph-bala-betabediox 1693: phhs-nme35pyr-gly-betapy 1694: ibhs-ithiadiaz-gly-betamesu 1695: bhs-25methiaz-gly-betabediox 1696: phhs-25thiaz-gly-betafu2 1697: 2py-24thiaz-bala-betaheph 1698: phhs-oxadiaz-gly-asppha 1699: ibhs-ithiadiaz-bala-psdap 1700: thpym-25methiaz-bala-psdap -72 1701: tolhs-25oxaz-bala-betabenfu 1702: ibhs-ithiadiaz-gly-betathio3 1703: bhs-25methiaz-gly-betampy 1704: bim-52thiaz-gly-betameph 5 1705: tolhs-nme35pyr-gly-beta23meoph 1706: bhs-ithiadiaz-bala-betaftrif 1707: bhs-25oxaz-gly-betadmoph 1708: phhs-24thiaz-gly-betainyl 1709: ibhs-25thiaz-gly-betaanaphth 0 1710: phhs-ithiadiaz-bala-betaphethio 1711: phhs-25thiaz-bala-betahdcph 1712: 4pmhs-25oxaz-gly-betapy 1713: bhs-53pyrazo-ala-betapy 1714: phhs-nme35pyr-bala-betathioph 5 1715: bhs-nme35pyr-nmgly-betamesu 1716: phhs-25oxaz-gly-betampy 1717: 2 py-25oxaz-bala-betaphethioa 1718: bhs-25methiaz-bala-betafu3 1719: phhs-me24oxaz-leu-betadcph 3 1720: bhs-25thiaz-ala-ibsdap 1721: bhs-ithiadiaz-gly-betabmph 1722: bhs-ithiadiaz-bala-betadmoph 1723: phhs-25thiaz-gly-betatbuph 1724: 2 py-42pym-ala-psdap 1725: ibhs-nme35pyr-gly-betaoxaz 1726: phhs-24thioph-bala-betafu3 1727: phhs-25oxaz-bala-betapbiph 1728: 2 py-me25oxaz-ala-betapy 1729: phhs-me24thiaz-gly-betaph 1730: bhs-25methiaz-nmgly-betaipro 1731: phhs-me24thiaz-leu-psdap 1732: gua-42pym-gly-betaphethio 1733: bhs-24thioph-gly-betaoxaz 1734: bhs-oxadiaz-bala-betahc 1735: ibhs-nme35pyr-gly-betainyl 1736: tolhs-nme35pyr-bala-psdaptb 1737: bhs-oxadiaz-bala-betadmph -73 1738: phhs-ithiadiaz-gly-betafbph 1739: phhs-25thiaz-gly-betahcbph 1740: tolhs-25oxaz-bala-betaibph 1741: tolhs-25oxaz-gly-betapych 5 1742: bhs-24thiaz-nmgly-betabnaphth 1743: phhs-25methiaz-gly-zdap 1744: 2py-42nmeim-gly-betaipro 1745: bhs-24thioph-bala-betafph 1746: ibhs-24thioph-bala-betambiph 0 1747: 2pmhs-42nmeim-gly-betahdcph 1748: 2py-24thiaz-gly-zdap 1749: phhs-oxadiaz-bala-betamethi 1750: bhs-me25thiaz-bala-betaph 1751: bhs-triaz-ala-betadcph 5 1752: bhs-25methiaz-bala-betahmofu 1753: bhs-25thiaz-ala-betafphe 1754: phhs-oxadiaz-bala-betafluo 1755: phhs-24thiaz-bala-betabenfu 1756: 2py-24thiaz-bala-aspbzla 3 1757: bhs-24thiaz-ala-psdap 1758: phhs-oxadiaz-gly-betapyee 1759: tolhs-25thiaz-bala-betaph 1760: ibhs-24thioph-bala-betaheph 1761: tolhs-24thioph-bala-zdaptb 1762: tolhs-24thiaz-gly-zdapee 1763: ibhs-ithiadiaz-bala-betaomebendi 1764: phhs-ithiadiaz-bala-betamethioph 1765: phhs-nme35pyr-bala-betathiobe 1766: phhs-25thiaz-bala-betafphe 1767: ibhs-25thiaz-bala-beta34dcph 1768: phhs-24thiaz-gly-psdaptb 1769: tolhs-24thioph-gly-betatos 1770: gua-26py-gly-betamethi 1771: bhs-oxadiaz-gly-betahmofu 1772: impy-42nmeim-gly-betahph 1773: bhs-24thiaz-bala-betadcphtb 1774: tolhs-ithiadiaz-gly-busu2be -74 1775: bim-me24oxaz-bala-beta34meoph 1776: tolhs-25methiaz-gly-betafu3 1777: tolhs-25oxaz-bala-aspbzla 1778: bhs-oxadiaz-ala-betacph 5 1779: phhs-ithiadiaz-bala-aspbzla 1780: ibhs-25thiaz-bala-betaph 1781: tolhs-oxadiaz-bala-csdap 1782: ibhs-oxadiaz-gly-betadtrif 1783: ibhs-25thiaz-gly-betadito 0 1784: tolhs-25oxaz-bala-suabu 1785: bhs-ithiadiaz-bala-zdap 1786: bhs-25thioph-gly-psdap 1787: 2py-24im-ala-zdap 1788: 2pmhs-25methiaz-gly-betaph 5 1789: phhs-25oxaz-gly-psdap 1790: bhs-24thioph-bala-betabenfu 1791: bim-me25oxaz-gly-betadcph 1792: bhs-oxadiaz-bala-betahmph 1793: ibhs-ithiadiaz-bala-betafph 1794: ibhs-25oxaz-bala-betacph 1795: ibhs-25methiaz-gly-betaipro 1796: ibhs-24thiaz-gly-betabph 1797: 2py-triaz-leu-betapy 1798: tolhs-nme35pyr-gly-zdapch 1799: bhs-thiadiaz-leu-betadcph 1800: tolhs-ithiadiaz-bala-beta34dcph 1801: phhs-25oxaz-bala-betampy 1802: tolhs-nme35pyr-gly-betabediox 1803: phhs-24thiaz-gly-betabenfu 1804: ibhs-24thioph-gly-betaanaphth 1805: ibhs-24thiaz-bala-betabthioph 1806: bhs-24thiaz-gly-betameph 1807: bhs-24thioph-bala-betaph 1808: ur-25oxaz-bala-zdap 1809: phhs-25thiaz-gly-betadcph 1810: ibhs-24thiaz-gly-betaphethio 1811: agua-24thioph-gly-psdap -75 1812: tolhs-24thiaz-bala-betadmoph 1813: phhs-nme35pyr-gly-betaheph 1814: bhs-ithiadiaz-gly-aspbzla 1815: cima-25methiaz-bala-psdap 5 1816: bim-25thiaz-bala-aspaba 1817: phhs-oxadiaz-bala-betahcbph 1818: phhs-me24thiaz-ala-betadcph 1819: bim-25oxaz-gly-betafph 1820: bhs-25methiaz-gly-betabenfu 0 1821: gua-42pym-gly-betabph 1822: bim-24thioph-bala-asppha 1823: ibhs-oxadiaz-bala-betamethi 1824: tolhs-24thiaz-bala-betabediox 1825: tolhs-25oxaz-bala-psdap 5 1826: ibhs-25thiaz-bala-beta35dbph 1827: ibhs-25oxaz-gly-betamesu 1828: ibhs-24thioph-gly-betambiph 1829: bhs-25oxaz-gly-betahcbph 1830: ibhs-24thioph-gly-betahc D 1831: 2py-25methiaz-gly-asppha) 1832: phhs-oxadiaz-gly-betacbph 1833: ibhs-ithiadiaz-bala-betaipro 1834: bhs-25thiaz-ala-betacthioph 1835: phhs-25thiaz-gly-aspibua 5 1836: ibhs-25methiaz-bala-betamesu 1837: bim-42nmeim-bala-betabediox 1838: tolhs-me25thioph-gly-betadcph 1839: ibhs-25methiaz-bala-betafbph 1840: phhs-25oxaz-gly-beta35dbph 1841: phhs-24thioph-bala-betaet 1842: ibhs-25oxaz-gly-betadcphee 1843: phhs-25oxaz-gly-betadtrif 1844: hs-42nmeim-bala-zdap 1845: bim-25methiaz-gly-betaibph 1846: bim-thiadiaz-ala-betapy 1847: 2py-me24im-ala-betapy 1848: bhs-24thiaz-gly-betamethioph -76 1849: tolhs-24thiaz-gly-beta23meoph 1850: tolhs-nme35pyr-bala-zdaptb 1851: ibhs-nme35pyr-gly-betah35dc 1852: bhs-25thiaz-gly-betahph 5 1853: bhs-25thiaz-bala-betatbuph 1854: ur-24thioph-gly-betadcph 1855: tolhs-me25thiaz-gly-psdap 1856: ibhs-24thiaz-gly-betafu2 1857: bhs-ithiadiaz-gly-betathiobe 0 1858: bim-25fur-bala-betapy 1859: phhs-25thiaz-gly-betahmph 1860: tolhs-nme35pyr-bala-betadbph 1861: ibhs-oxadiaz-bala-betamesu 1862: ibhs-25oxaz-bala-betabediox 5 1863: tolhs-oxadiaz-bala-betabnaphth 1864: bhs-oxadiaz-bala-zdapee 1865: ibhs-24thiaz-bala-betafph 1866: tolhs-25methiaz-bala-betaibph 1867: bhs-24thioph-gly-betatrif ) 1868: 3pmhs-42nmeim-bala-zdap 1869: phhs-nme35pyr-gly-betathioph 1870: tolhs-nme35pyr-bala-busu2be 1871: bhs-24thiaz-gly-betaoxope 1872: tolhs-24thiaz-gly-betatrif 5 1873: bhs-25methiaz-gly-betahmo 1874: tolhs-oxadiaz-gly-betahph 1875: phhs-ithiadiaz-gly-zdaptb 1876: bim-42nmeim-bala-betahmofu 1877: 2py-thiadiaz-gly-zdap 1878: bhs-ithiadiaz-gly-betahmo 1879: bim-25thiaz-gly-aspibua 1880: bhs-nme35pyr-gly-betapy 1881: bhs-ithiadiaz-ala-betapy 1882: ibhs-nme35pyr-bala-betafphe 1883: bhs-53pyrazo-bala-betadcph 1884: ibhs-25methiaz-gly-betahcbph 1885: tolhs-25methiaz-gly-betaphethio -77 1886: bhs-24thiaz-bala-beta23meoph 1887: ibhs-nme35pyr-gly-zdap 1888: bhs-25thiaz-gly-betadcphtb 1889: gua-26py-gly-betacbph 5 1890: 2py-25thiaz-gly-betathio3 1891: tolhs-24thioph-bala-betapyee 1892: bhs-oxadiaz-gly-betaoxaz 1893: ibhs-25thiaz-bala-betahdbph 1894: ibhs-ithiadiaz-bala-betaheph 0 1895: ibhs-24thiaz-gly-betahmofu 1896: tolhs-24thioph-bala-betaoxaz 1897: phhs-25methiaz-gly-betapbiph 1898: tolhs-24thiaz-gly-betamethi 1899: tolhs-24thiaz-bala-betamethioph 5 1900: bhs-ithiadiaz-bala-betapyee 1901: bhs-25thiaz-bala-zdaptb 1902: ibhs-nme35pyr-bala-beta34meoph 1903: tolhs-me25thioph-ala-zdap 1904: ibhs-25methiaz-gly-betaamibe ) 1905: phhs-25oxaz-bala-betabdimo 1906: 2py-triaz-gly-betapy 1907: ibhs-25oxaz-bala-betadcphch 1908: bhs-oxadiaz-nmgly-betadmph 1909: bhs-24thiaz-bala-beta35dbph 1910: tolhs-24thioph-gly-betapy 1911: gua-26py-gly-betacthioph 1912: bhs-25oxaz-bala-betapy 1913: dhpyrr-25thiaz-gly-betapy 1914: tolhs-24thioph-bala-betapym 1915: ibhs-24thioph-bala-betapbiph 1916: gua-26py-gly-betaipro 1917: bim-oxadiaz-bala-aspibua 1918: tolhs-nme35pyr-bala-betadtrif 1919: tolhs-25thiaz-gly-betafluo 1920: phhs-oxadiaz-bala-beta23meoph 1921: tolhs-25oxaz-bala-beta34dcph 1922: 2py-me24oxaz-ala-betapy -78 1923: tolhs-25methiaz-gly-betapym 1924: phhs-nme35pyr-gly-betahdcph 1925: tolhs-oxadiaz-gly-betafbph 1926: tolhs-25methiaz-bala-csdap 5 1927: bhs-24im-gly-psdap 1928: 2py-me25oxaz-bala-beta34meoph 1929: ibhs-25oxaz-gly-betahdbph 1930: ibhs-oxadiaz-bala-betahcbph 1931: phhs-24thioph-bala-csdap 0 1932: tolhs-24thiaz-gly-betameph 1933: bhs-24thioph-gly-betacbph 1934: ibhs-24thiaz-gly-psdapee 1935: phhs-24thiaz-gly-betafluo 1936: gua-42pym-gly-betacthioph 5 1937: bhs-25thiaz-bala-betadhbfu 1938: bhs-oxadiaz-bala-betadhbfu 1939: phhs-25methiaz-gly-busu2be 1940: phhs-24thiaz-gly-psdap 1941: ibhs-24thioph-bala-betathiobe 0 1942: phhs-ithiadiaz-gly-betatbuph 1943: tolhs-25methiaz-bala-betahmofu 1944: sabhs-24thioph-gly-psdap 1945: ibhs-25oxaz-gly-betaoxope 1946: tolhs-25thiaz-gly-beta34dcph 5 1947: phhs-nme35pyr-gly-betabph 1948: phhs-25thiaz-gly-betatrif 1949: bhs-ithiadiaz-ala-betadito 1950: bim-25thiaz-ala-betameph 1951: 2py-35fur-gly-betadcph 1952: ibhs-25methiaz-gly-betabdimo 1953: cima-24thioph-bala-psdap 1954: phhs-24thioph-gly-betafph 1955: ibhs-ithiadiaz-bala-betafphe 1956: bim-24im-leu-betapy 1957: bhs-25thioph-gly-betacph 1958: impy-24thiaz-bala-betainyl 1959: bim-25methiaz-bala-asppha -79 1960: bhs-24thioph-bala-betadcphtb 1961: ibhs-oxadiaz-bala-psdaptb 1962: 2py-me24thioph-gly-psdap 1963: 2pmhs-24thiaz-bala-betamethioph 5 1964: ibhs-25methiaz-bala-betampy 1965: bhs-24thiophme-gly-betameph 1966: bhs-ithiadiaz-gly-betatrif 1967: dhim-26py-ala-betatbuph 1968: thpym-25thiaz-gly-betadcph 0 1969: 2py-thiadiaz-ala-betapy 1970: 2py-25methiaz-bala-betaoxope 1971: tolhs-25methiaz-gly-ibsdap 1972: ibhs-ithiadiaz-gly-betaoxaz 1973: phhs-25thiaz-bala-asppha 5 1974: 2py-42nmeim-gly-betampy 1975: 2py-26py-ala-betapy 1976: phhs-24thiaz-gly-betadcphtb 1977: 3pmhs-24thioph-bala-betapy 1978: 2py-25thiaz-bala-aspbzla 3 1979: gua-42pym-gly-betahmo 1980: gua-26py-gly-betaamibe 1981: tolhs-25methiaz-gly-zdapee 1982: ibhs-25oxaz-gly-psdapch 1983: bhs-25thiaz-nmgly-betadmph 1984: bhs-nme35pyr-bala-betadmoph 1985: agua-25thiaz-gly-betadcph 1986: phhs-25methiaz-gly-betameph 1987: bhs-24thiaz-gly-beta35dbph 1988: ibhs-ithiadiaz-gly-betafphe 1989: bim-25oxaz-leu-betapy 1990: phhs-ithiadiaz-bala-betahmph 1991: 2py-24thioph-bala-betaet 1992: 2py-me24thiaz-gly-betaph 1993: 2py-24im-ala-betadcph 1994: bhs-25thiaz-gly-betadmoph 1995: phhs-ithiadiaz-bala-betaet 1996: ibhs-25thiaz-bala-betaphethio -80 1997: phhs-oxadiaz-bala-betahbcph 1998: ibhs-25methiaz-bala-betafphe 1999: ibhs-25thiaz-gly-suabu 2000: bim-24thiaz-ala-betameph 5 2001: phhs-me25thiaz-bala-betaph 2002: ibhs-25thiaz-gly-betapyr 2003: bhs-me25thioph-bala-betaph 2004: bhs-25oxaz-bala-aspaba 2005: 2 pmhs-25thiaz-bala-betathioph 0 2006: tolhs-oxadiaz-bala-psdap 2007: bhs-nme35pyr-gly-betaoxaz 2008: tolhs-25thiaz-gly-beta23meoph 2009: phhs-25methiaz-gly-betaamibe 2010: gua-25thioph-gly-betapy 5 2011: 2py-nme35pyr-gly-psdap 2012: ibhs-ithiadiaz-gly-betahdbph 2013: 2py-25oxaz-gly-betacbph 2014: bim-me24thioph-leu-zdap 2015: bhs-25thiaz-ala-betal 3bendi 0 2016: phhs-24thioph-gly-betatrif 2017: 2py-ithiadiaz-gly-betapy 2018: phhs-nme35pyr-gly-betapytb 2019: ibhs-ithiadiaz-gly-betaanaphth 2020: bhs-nme35pyr-ala-betaanaphth 5 2021: tolhs-nme35pyr-gly-betapych 2022: 2py-me25thioph-bala-psdap 2023: ibhs-24thiaz-gly-betaet 2024: tolhs-24thioph-gly-beta3quin 2025: tolhs-24thiaz-bala-betaoxope 2026: ibhs-25methiaz-gly-beta34meoph 2027: ibhs-25oxaz-bala-betambiph 2028: phhs-25oxaz-gly-betafbph 2029: tolhs-24thiaz-gly-betathio3 2030: phhs-ithiadiaz-gly-betaipro 2031: phhs-25oxaz-gly-betacthioph 2032: bhs-25thiaz-bala-betaibph 2033: impy-24thioph-nmgly-psdap -81 2034: bhs-24im-gly-zdap 2035: bhs-thiadiaz-leu-betapy 2036: gua-25thiophme-gly-betapy 2037: bhs-24thiaz-gly-betafluo 5 2038: tolhs-oxadiaz-bala-betathioph 2039: bhs-24im-ala-betapy 2040: bhs-24thiaz-bala-betabph 2041: bim-25oxaz-bala-betathioph 2042: bhs-nme35pyr-gly-betaamibe 0 2043: phhs-25oxaz-gly-beta23meoph 2044: ibhs-ithiadiaz-gly-betabdimo 2045: phhs-25methiaz-gly-betaipro 2046: phhs-24thiaz-gly-beta34meoph 2047: phhs-25thiaz-gly-betafluo 5 2048: bhs-25methiaz-bala-betaanaphth 2049: toihs-25thiaz-bala-psdapee 2050: tolhs-24thiaz-gly-betafphe 2051: bhs-24thioph-gly-betafluo 2052: phhs-nme35pyr-gly-betahni 2053: 2py-me24thioph-bala-betapy 2054: ibhs-25methiaz-gly-betafbph 2055: 2py-nme35pyr-bala-aspaba 2056: bhs-24thiaz-gly-betatbuph 2057: 2py-42pym-gly-betapy 2058: tolhs-24thiaz-bala-betahmofu 2059: ibhs-25thiaz-gly-betatos 2060: ibhs-nme35pyr-bala-suabu 2061: ibhs-25methiaz-gly-betamethioph 2062: ibhs-25thiaz-bala-betadito 2063: hyd-24thiaz-bala-betameph 2064: tolhs-nme35pyr-gly-betacph 2065: bhs-25oxaz-ala-betafphe 2066: bhs-oxadiaz-gly-aspbzla 2067: tolhs-24thiaz-bala-ibsdap 2068: bim-ithiadiaz-leu-betadcph 2069: 2py-24thioph-gly-betaol 2070: tolhs-24thiaz-gly-betamesu -82 2071: ibhs-24thiaz-gly-betahdcph 2072: bhs-25methiaz-nmgly-beta3quin 2073: ibhs-24thioph-gly-betaphethio 2074: bhs-24thioph-bala-betathiobe 5 2075: bhs-25thiaz-gly-asppha 2076: phhs-nme35pyr-bala-betaphethioa 2077: 2py-25methiaz-leu-betadcph 2078: tolhs-ithiadiaz-bala-betafphe 2079: bhs-25oxaz-bala-betadmph 0 2080: bhs-nme35pyr-bala-betaftrif 2081: tolhs-25methiaz-gly-betapyee 2082: bim-oxadiaz-leu-psdap 2083: tolhs-ithiadiaz-gly-betahc 2084: gua-25thiaz-gly-betahc 5 2085: 2py-53pyrazo-gly-zdap 2086: nmhs-42pym-gly-betainyl 2087: tolhs-24thiaz-gly-betainyl 2088: phhs-25oxaz-bala-psdapch 2089: bhs-24thiaz-gly-betathiome 3 2090: bhs-nme35pyr-gly-betabediox 2091: phhs-25thiaz-gly-betahph 2092: bhs-24thiaz-nmgly-betabpy 2093: ibhs-25methiaz-bala-betafu3 2094: phhs-24thioph-gly-betaoxope 2095: bhs-25methiaz-gly-busu2be 2096: dhim-24thiaz-ala-zdap 2097: bhs-ithiadiaz-bala-betainyl 2098: phhs-25methiaz-gly-betaomebendi 2099: bim-52thiaz-ala-betameph 2100: bim-35thioph-bala-zdap 2101: ibhs-25thiaz-bala-aspbzla 2102: ibhs-25thiaz-gly-busu2be 2103: tolhs-nme35pyr-gly-betaomebendi 2104: phhs-25methiaz-gly-betaet 2105: bhs-24thiaz-gly-betahdcph 2106: bim-42nmeim-gly-betah35dc 2107: bhs-me24thioph-gly-betapy -83 2108: phhs-25thiaz-gly-zdapee 2109: ibhs-nme35pyr-bala-betadbph 2110: tolhs-me25thiaz-gly-betaph 2111: bhs-me25thioph-bala-zdap 5 2112: impy-25oxaz-bala-betadmoph 2113: tolhs-25thiaz-bala-betal 3bendi 2114: bhs-35fur-gly-psdap 2115: gua-25thioph-gly-betaph 2116: ibhs-25oxaz-bala-betaamibe 0 2117: 2py-24oxaz-leu-betadcph 2118: ibhs-ithiadiaz-gly-betahmofu 2119: bim-25thioph-ala-betapy 2120: ibhs-ithiadiaz-gly-betadcphee 2121: tolhs-me25oxaz-gly-betadcph 5 2122: tolhs-25methiaz-bala-betaheph 2123: ibhs-ithiadiaz-gly-betapy 2124: bhs-35py-ala-betapy 2125: bhs-35thioph-bala-psdap 2126: tolhs-me24thioph-bala-zdap 2127: phhs-25methiaz-gly-betahdcph 2128: bhs-25thiaz-bala-psdapee 2129: bhs-me25thioph-gly-beta34meoph 2130: phhs-oxadiaz-gly-betahdcph 2131: tolhs-25oxaz-gly-betaanaphth 2132: tolhs-25thiaz-bala-csdap 2133: 2py-ithiadiaz-leu-zdap 2134: ibhs-25oxaz-bala-betamethi 2135: bhs-25oxaz-bala-aspbzla 2136: phhs-nme35pyr-bala-betah35dc 2137: ibhs-24thioph-bala-betadcphch 2138: phhs-25methiaz-bala-betathiome 2139: 2py-52thiaz-ala-betapy 2140: ibhs-24thioph-gly-betabdimo 2141: dimethpym-25thiaz-gly-betameph 2142: bhs-25methiaz-gly-betaftrif 2143: tolhs-24thiaz-gly-betacph 2144: bhs-oxadiaz-bala-betapytb -84 2145: ibhs-oxadiaz-bala-betafbph 2146: ibhs-25thiaz-gly-betacbph 2147: phhs-24thioph-bala-betafluo 2148: phhs-me24thiaz-bala-beta34meoph 5 2149: tofhs-25thiaz-bala-betapyr 2150: phhs-25oxaz-bala-betadhbfu 2151: ibhs-25oxaz-bala-betadito 2152: bhs-24thioph-gly-betameph 2153: bhs-24thioph-bala-betacbph 0 2154: bim-25oxaz-gly-aspbzla 2155: impy-24thioph-gly-beta34meoph 2156: bhs-ithiadiaz-nmgly-betadmoph 2157: bim-35thioph-ala-betapy 2158: tolhs-25thiaz-bala-betadmph 5 2159: phhs-24thioph-bala-betaphethioa 2160: ibhs-25oxaz-bala-betafu2 2161: ibhs-nme35pyr-gly-betatrif 2162: 2py-24thiaz-gly-beta3quin 2163: 2pmhs-25thiaz-gly-psdap 0 2164: bhs-25oxaz-gly-betatos 2165: tolhs-25methiaz-gly-beta3quin 2166: tolhs-24thioph-bala-betabthioph 2167: impy-25methiaz-bala-betamesu 2168: phhs-25oxaz-bala-psdapee 2169: tolhs-25thiaz-gly-betah35dc 2170: tolhs-24thioph-bala-betafu3 2171: bhs-25methiaz-gly-betabdimo 2172: bhs-25fur-gly-betadcph 2173: phhs-ithiadiaz-bala-psdapch 2174: tolhs-25oxaz-gly-betadito 2175: tolhs-oxadiaz-gly-betamesu 2176: bhs-25oxaz-bala-betabenfu 2177: ibhs-25methiaz-gly-betadcph 2178: bhs-24thioph-gly-betadito 2179: ibhs-24thiaz-bala-betaoxope 2180: tolhs-25methiaz-bala-betampy 2181: ibhs-ithiadiaz-bala-aspaba -85 2182: 2py-me25oxaz-ala-betadcph 2183: ibhs-24thioph-gly-betapytb 2184: ibhs-ithiadiaz-bala-betainyl 2185: phhs-me25thiaz-gly-psdap 5 2186: phhs-oxadiaz-gly-betahb 2187: bhs-nme35pyr-ala-beta34dcph 2188: phhs-me24thiaz-ala-zdap 2189: bhs-42nmeim-leu-betapy 2190: tolhs-24thiaz-gly-betaftrif 0 2191: ibhs-oxadiaz-gly-betahmph 2192: tolhs-ithiadiaz-bala-betahb 2193: bhs-35thioph-leu-betadcph 2194: bhs-25thiaz-bala-betadcph 2195: phhs-nme35pyr-gly-betapyr 5 2196: ibhs-ithiadiaz-gly-zdap 2197: phhs-25oxaz-bala-betahdcph 2198: bhs-oxadiaz-gly-betaibph 2199: 2py-me24thioph-leu-betaph 2200: tolhs-24thioph-gly-beta34dcph 3 2201: bhs-24thiaz-nmgly-betacph 2202: bhs-25oxaz-bala-betapyr 2203: bhs-25fur-leu-zdap 2204: impy-240xaz-gly-betameph 2205: bhs-nme35pyr-gly-betahb 2206: tolhs-me24thiaz-bala-psdap 2207: ibhs-24thioph-gly-beta35dbph 2208: ibhs-24thioph-bala-betathio3 2209: bhs-24thiaz-bala-asppha 2210: bhs-24thioph-ala-betaanaphth 2211: ibhs-24thioph-bala-betahph 2212: tolhs-nme35pyr-bala-asppha 2213: bim-thiadiaz-leu-zdap 2214: 2py-35fur-bala-betapy 2215: phhs-24thioph-bala-betathioph 2216: phhs-ithiadiaz-bala-betadhbfu 2217: bhs-25thiaz-nmgly-betameph 2218: tolhs-ithiadiaz-gly-betahb -86 2219: 2py-ithiadiaz-gly-aspibua 2220: ibhs-25methiaz-bala-betamethioph 2221: bhs-oxadiaz-gly-betaet 2222: ibhs-nme35pyr-gly-betatos 5 2223: bhs-me25oxaz-gly-psdap 2224: bhs-25oxaz-bala-zdapee 2225: bhs-26py-gly-betal 3bendi 2226: bhs-25fur-ala-betadcph 2227: ibhs-24thioph-gly-zdapch 0 2228: tolhs-25thiaz-bala-betadcphtb 2229: phhs-24thioph-bala-betadbph 2230: 2py-25oxaz-bala-aspbzla 2231: 2 py-me25thioph-ala-beta34meoph 2232: ibhs-25thiaz-bala-beta34meoph 5 2233: ibhs-24thioph-bala-zdap 2234: phhs-24thiaz-bala-betathio3 2235: bhs-24thioph-bala-betatrif 2236: bhs-nme35pyr-bala-betadito 2237: phhs-nme35pyr-gly-betacbph 2238: bhs-24thioph-ala-betaoxaz 2239: -impy-25thiaz-bala-betaphethioa 2240: 2py-25oxaz-bala-betafu3 2241: 2py-oxadiaz-ala-betapy 2242: ibhs-25methiaz-bala-betaet 2243: ibhs-ithiadiaz-gly-betatbuph 2244: phhs-24thioph-bala-betaol 2245: phhs-25thiaz-bala-beta23meoph 2246: phhs-25oxaz-bala-betabthioph 2247: bim-24im-bala-psdap 2248: bim-nme35pyr-gly-aspaba 2249: ibhs-25oxaz-bala-betaimid 2250: impy-24thiaz-gly-betaipr 2251: tolhs-25thiaz-bala-betapbiph 2252: phhs-25oxaz-bala-betadcph 2253: ibhs-ithiadiazgly-beta-4bph 2254: bhs-oxadiaz-gly-betah35dc 2255: phhs-oxadiaz-gly-betaipro -87 2256: bhs-25methiaz-nmgly-betathio3 2257: bim-35thioph-leu-zdap 2258: phhs-25oxaz-bala-betaipr 2259: ibhs-25methiaz-gly-zdapch 5 2260: bim-me25thiaz-bala-zdap 2261: phhs-nme35pyr-bala-betaamibe 2262: bhs-25thiaz-bala-aspaba 2263: bhs-24thiaz-gly-betathioph 2264: bhs-25oxaz-gly-betaphethio 0 2265: bhs-ithiadiaz-bala-betabediox 2266: phhs-nme35pyr-gly-betabnaphth 2267: bhs-nme35pyr-gly-betadtrif 2268: tolhs-25thiaz-bala-betainyl 2269: bhs-24thioph-gly-betabnaphth 5 2270: phhs-ithiadiaz-bala-betacbph 2271: bhs-25methiaz-bala-betatbuph 2272: bhs-25methiaz-ala-betathio3 2273: bim-25methiaz-gly-zdap 2274: tolhs-oxadiaz-gly-betafu2 2275: ibhs-24thiaz-bala-beta35dbph 2276: bhs-nme35pyr-gly-betadito 2277: bhs-oxadiaz-ala-ibsdap 2278: ibhs-25methiaz-gly-betal 3bendi 2279: phhs-24thioph-bala-psdap 2280: ibhs-ithiadiaz-bala-betatos 2281: tolhs-25thiaz-gly-psdapch 2282: bhs-25methiaz-gly-betadhbfu 2283: phhs-24thiaz-gly-betaipro 2284: ibhs-oxadiaz-gly-zdap 2285: tolhs-nme35pyr-bala-betafphe 2286: bhs-25thiaz-ala-betaoxaz 2287: ibhs-24thioph-bala-betaet 2288: ibhs-24thiaz-bala-betafu3 2289: bhs-25oxaz-ala-ibsdap 2290: bhs-25methiaz-nmgly-betadito 2291: bim-24thioph-gly-betapbiph 2292: ibhs-25thiaz-bala-betadtrif -88 2293: tolhs-25methiaz-bala-betah35dc 2294: phhs-25methiaz-gly-betabdimo 2295: 2py-25oxaz-bala-aspibua 2296: ibhs-25thiaz-bala-betahmofu 5 2297: phhs-oxadiaz-gly-betathiome 2298: tolhs-oxadiaz-gly-betaomebendi 2299: tolhs-25thiaz-giy-betabmph 2300: ibhs-oxadiaz-bala-betahdcph 2301: 2py-me24thioph-leu-beta34meoph 0 2302: phhs-nme35pyr-gly-betabediox 2303: ibhs-nme35pyr-bala-betaibph 2304: 2py-me25thioph-bala-beta34meoph 2305: bhs-24thiaz-bala-betatos 2306: bhs-25thiaz-gly-betaol 5 2307: phhs-25oxaz-gly-betahb 2308: ibhs-oxadiaz-bala-betaphethioa 2309: tolhs-25thiaz-bala-betahmofu 2310: bhs-nme35pyr-ala-betahph 2311: ibhs-25oxaz-bala-betaibph 3 2312: tolhs-25oxaz-bala-betadmph 2313: 2py-me25oxaz-bala-zdap 2314: bhs-24thiaz-gly-betacph 2315: bim-oxadiaz-ala-zdap 2316: tolhs-25oxaz-bala-betamethi 2317: 2py-25thioph-ala-betadcph 2318: bhs-24thiaz-nmgly-ibsdap 2319: bim-42nmeim-gly-busu2be 2320: phhs-me24thioph-ala-betadcph 2321: bhs-24thiaz-nmgly-betadhbfu 2322: 2py-me25thiaz-bala-betapy 2323: bim-25thioph-gly-zdap 2324: tolhs-25oxaz-gly-betahmofu 2325: bhs-25methiaz-gly-betahmofu 2326: phhs-ithiadiaz-bala-suabu 2327: ibhs-25oxaz-gly-betamethi 2328: gua-26py-gly-betapy 2329: tolhs-25oxaz-gly-betapy -89 2330: bhs-me25oxaz-ala-betaph 2331: tolhs-nme35pyr-gly-betambiph 2332: bhs-24thioph-gly-betathiome 2333: phhs-25thiaz-gly-betaet 5 2334: tolhs-ithiadiaz-bala-betapyr 2335: phhs-24thioph-bala-zdapch 2336: tolhs-25methiaz-gly-zdap 2337: ibhs-24thiaz-gly-betacbph 2338: bhs-oxadiaz-bala-betahph 0 2339: tolhs-24thiaz-bala-betafu2 2340: ibhs-24thiaz-gly-psdap 2341: ibhs-ithiadiaz-bala-betabenfu 2342: bim-25oxaz-bala-psdap 2343: phhs-me25oxaz-leu-betapy 5 2344: ibhs-nme35pyr-bala-betabph 2345: bim-me25thioph-leu-betadcph 2346: bhs-ithiadiaz-bala-betabenfu 2347: phhs-25methiaz-bala-betabithioph 2348: bhs-nme35pyr-bala-psdapee 2349: ibhs-24thioph-bala-betabdimo 2350: ibhs-24thioph-gly-betaoxope 2351: bim-42pym-ala-zdap 2352: gua-26py-gly-suabu 2353: ibhs-25thiaz-bala-betaipro 2354: phhs-ithiadiaz-gly-betapytb 2355: 2pmhs-25thiaz-gly-betameph 2356: bim-me24thioph-bala-psdap 2357: phhs-25thiaz-bala-betaphethio 2358: tolhs-oxadiaz-bala-betahbcph 2359: bhs-26py-gly-psdap 2360: bhs-24thiaz-gly-betaanaphth 2361: dhim-2thioph-gly-betameph 2362: 2py-me24thioph-leu-betadcph 2363: tolhs-24thiaz-bala-betabmph 2364: bhs-25oxaz-bala-beta35dbph 2365: tolhs-25methiaz-gly-betadhbfu 2366: bhs-24thioph-bala-betafluo -90 2367: tolhs-24thiaz-bala-betaol 2368: bim-24thioph-gly-betadbph 2369: phhs-24thioph-bala-betabph 2370: phhs-nme35pyr-bala-betacbph 5 2371: tolhs-ithiadiaz-bala-betadhbfu 2372: 2py-24oxaz-gly-betainyl 2373: ibhs-24thioph-gly-zdaptb 2374: 2py-25fur-leu-betadcph 2375: bhs-24thiaz-gly-betaimid 0 2376: ibhs-25methiaz-bala-betal 3bendi 2377: bhs-24thiaz-bala-betapyr 2378: ibhs-24thiaz-bala-suabu 2379: tolhs-oxadiaz-gly-betambiph 2380: bhs-oxadiaz-nmgly-betathioph 5 2381: phhs-25methiaz-gly-betabediox 2382: ibhs-25thiaz-gly-betameph 2383: phhs-24thioph-bala-betaipro 2384: bhs-24chin-ala-betameph 2385: tolhs-25oxaz-gly-betainyl 0 2386: 2py-25oxaz-bala-betapy 2387: tolhs-25methiaz-gly-betacph 2388: ibhs-25oxaz-bala-beta1 3bendi 2389: tolhs-25oxaz-gly-beta3quin 2390: ibhs-25oxaz-bala-zdap 5 2391: tolhs-24thioph-bala-betal 3bendi 2392: phhs-me24oxaz-bala-psdap 2393: bim-24thioph-bala-betatos 2394: tolhs-me25oxaz-ala-zdap 2395: bhs-me24oxaz-bala-zdap 2396: bhs-25thiaz-bala-betadbph 2397: phhs-ithiadiaz-gly-betainyl 2398: ibhs-ithiadiaz-gly-betapytb 2399: ibhs-24thiaz-gly-betah35dc 2400: tolhs-24thiaz-gly-betatbuph 2401: phhs-24thiaz-bala-betampy 2402: bhs-53pyrazo-bala-betapy 2403: 2py-25oxaz-bala-betadcph -91 2404: phhs-me24thioph-leu-betapy 2405: tolhs-ithiadiaz-bala-betaanaphth 2406: ibhs-oxadiaz-bala-betaph 2407: phhs-25methiaz-gly-betafu2 5 2408: phhs-24thioph-gly-betadbph 2409: phhs-24thioph-bala-psdapee 2410: ibhs-24thiaz-bala-betacph 2411: bhs-me25thiaz-gly-betadcph 2412: phhs-oxadiaz-bala-betabpy 0 2413: ibhs-24thioph-gly-beta34dcph 2414: ibhs-25thiaz-gly-betapbiph 2415: tolhs-24thiaz-bala-beta34meoph 2416: tolhs-ithiadiaz-bala-betapbiph 2417: phhs-nme35pyr-bala-betadcph 5 2418: 2pmhs-25methiaz-gly-betathiome 2419: bhs-me25thiaz-bala-psdap 2420: phhs-ithiadiaz-gly-betabenfu 2421: 2py-nme35pyr-leu-betadcph 2422: phhs-24thioph-bala-betadmph 2423: bhs-24thioph-bala-betahcbph 2424: 2py-25methiaz-bala-asppha 2425: 2py-26py-gly-betampy 2426: ibhs-nme35pyr-gly-zdapch 2427: tolhs-me24thiaz-ala-betapy 2428: tolhs-nme35pyr-gly-betapbiph 2429: phhs-ithiadiaz-gly-betapyee 2430: bhs-25oxaz-gly-beta34meoph 2431: 2py-35thioph-leu-betadcph 2432: ibhs-nme35pyr-gly-betabph 2433: bhs-ithiadiaz-gly-betaphethio 2434: tolhs-25thiaz-gly-zdapch 2435: 2py-24thioph-ala-zdap 2436: tolhs-ithiadiaz-gly-betahph 2437: phhs-25methiaz-bala-betaphethioa 2438: ibhs-25oxaz-gly-betah35dc 2439: gua-25thioph-gly-betaphethio 2440: bim-35fur-gly-psdap -92 2441: ibhs-ithiadiaz-bala-betaftrif 2442: tolhs-24thiaz-gly-beta34meoph 2443: bhs-25methiaz-bala-betacthioph 2444: bhs-nme35pyr-ala-betaoxaz 5 2445: 2py-me24thioph-gly-zdap 2446: 2py-25oxaz-gly-betambiph 2447: bhs-42nmeim-gly-psdap 2448: bhs-oxadiaz-gly-psdapee 2449: phhs-ithiadiaz-gly-betafph 0 2450: thazep-42pym-gly-betal 3bendi 2451: phhs-25methiaz-bala-betabmph 2452: bhs-25methiaz-bala-betapbiph 2453: phhs-nme35pyr-gly-suabu 2454: ibhs-ithiadiaz-bala-betamethioph 5 2455: 2pmhs-24thioph-gly-betafph 2456: tolhs-24thiaz-gly-betacbph 2457: phhs-25thiaz-bala-betathio3 2458: ibhs-oxadiaz-bala-betamethioph 2459: ibhs-25thiaz-gly-aspibua D 2460: bhs-42nmeim-bala-betadcph 2461: phhs-25oxaz-bala-betaomebendi 2462: phhs-nme35pyr-gly-asppha 2463: ibhs-24thiaz-bala-betainyl 2464: bim-25oxaz-gly-aspibua 2465: bhs-ithiadiaz-ala-betafphe 2466: bhs-25oxaz-bala-betafphe 2467: ibhs-ithiadiaz-gly-betaibph 2468: gua-26py-gly-betabnaphth 2469: ibhs-25oxaz-gly-betathioph P 2470: phhs-25methiaz-gly-betathiobe 2471: ibhs-24thiaz-gly-betadbph 2472: tolhs-ithiadiaz-gly-betabthioph 2473: bhs-oxadiaz-gly-busu2be 2474: phhs-24thioph-gly-betaphethioa 2475: bhs-24thiaz-ala-betameph 2476: tolhs-25thiaz-bala-betaol 2477: bhs-ithiadiaz-bala-betahmofu -93 2478: phhs-ithiadiaz-bala-betaph 2479: bhs-35fur-gly-betapy 2480: ibhs-24thioph-bala-betapych 2481: phhs-25oxaz-gly-betal 3bendi 5 2482: bhs-25thiaz-ala-betadito 2483: bhs-ithiadiaz-bala-psdap 2484: bim-24thioph-bala-betaipro 2485: phhs-24thioph-bala-beta34dcph 2486: tolhs-me24thioph-leu-betapy 0 2487: phhs-25methiaz-gly-betahmph 2488: tolhs-oxadiaz-gly-betatbuph 2489: bhs-me24thioph-bala-zdap 2490: phhs-24thioph-gly-betahmo 2491: bhs-nme35pyr-gly-betabmph 5 2492: bim-24thioph-gly-zdap 2493: ibhs-25thiaz-bala-betahc 2494: ibhs-ithiadiaz-bala-zdaptb 2495: bhs-24thiaz-gly-betadcphee 2496: ibhs-24thioph-bala-betacbph 0 2497: ibhs-ithiadiaz-bala-betaph 2498: ibhs-25methiaz-gly-betahdcph 2499: phhs-24thiaz-bala-betafbph 2500: phhs-25oxaz-gly-betadhbfu 2501: bhs-42oxaz-leu-zdap 5 2502: phhs-ithiadiaz-gly-betaomebendi 2503: phhs-24thiaz-bala-beta4bph 2504: bhs-24thioph-bala-betaipro 2505: phhs-oxadiaz-bala-betahc 2506: tolhs-25oxaz-bala-betadito 2507: bhs-nme35pyr-gly-betapbiph 2508: bhs-25methiaz-gly-betameph 2509: ibhs-25oxaz-bala-beta4bph 2510: ibhs-ithiadiaz-bala-betadtrif 2511: bhs-ithiadiaz-gly-betabph 2512: bhs-25oxaz-bala-betal 3bendi 2513: tolhs-25oxaz-bala-betafluo 2514: tolhs-25thiaz-bala-aspibua -94 2515: ibhs-24thiaz-gly-betapytb 2516: tolhs-me25oxaz-leu-psdap 2517: phhs-25methiaz-bala-betahph 2518: bhs-24thioph-ala-betadhbfu 5 2519: bim-24thiaz-phg-zdap 2520: bhs-me25thiaz-bala-betapy 2521: 2py-35fur-bala-psdap 2522: phhs-me25thioph-ala-betadcph 2523: bhs-me25thiaz-gly-betaph 0 2524: phhs-25thiaz-gly-asppha 2525: phhs-25methiaz-gly-betadcphtb 2526: ibhs-nme35pyr-bala-betapbiph 2527: phhs-ithiadiaz-gly-betadtrif 2528: bhs-24thiaz-gly-betabdimo 5 2529: bhs-25methiaz-ala-betabnaphth 2530: 2py-me25thiaz-leu-zdap 2531: ibhs-24thiaz-gly-betaipr 2532: dhim-25thioph-gly-betahcbph 2533: tolhs-me24thiaz-leu-beta34imeoph ) 2534: bhs-25thiaz-bala-betaipro 2535: bim-me24thiaz-ala-psdap 2536: gua-25thioph-gly-betapbiph 2537: 2pmhs-24thioph-gly-betaph 2538: bhs-24thioph-bala-betaibph 5 2539: tolhs-24thioph-bala-betabnaphth 2540: bhs-nme35pyr-bala-betampy 2541: bim-ithiadiaz-bala-aspbzla 2542: ur-25thioph-gly-zdap 2543: bhs-24thioph-gly-betatos 2544: bhs-nme35pyr-gly-aspaba 2545: tolhs-ithiadiaz-gly-zdapch 2546: ibhs-24thioph-gly-betapyr 2547: bhs-ithiadiaz-bala-betaibph 2548: bhs-25methiaz-bala-betathiobe 2549: ibhs-25thiaz-bala-beta1 3bendi 2550: bhs-24thioph-ala-betainyl 2551: 2pmhs-25oxaz-gly-betadito -95 2552: tolhs-oxadiaz-bala-ibsdap 2553: bim-me24oxaz-leu-betadcph 2554: phhs-25thiaz-bala-betainyl 2555: phhs-me24oxaz-bala-betaph 5 2556: bhs-23thioph-gly-betapy 2557: tolhs-25m ethiaz-bala-betafbph 2558: bhs-oxadiaz-bala-betabenfu 2559: phhs-24thiaz-gly-betadcph 2560: phhs-25oxaz-gly-betaomebendi 0 2561: tolhs-nme35pyr-gly-betadcph 2562: ibhs-24thioph-bala-zdapch 2563: tolhs-nme35pyr-gly-betah35dc 2564: ibhs-25thiaz-gly-betabthioph 2565: tolhs-24thioph-gly-betabediox 5 2566: bhs-25thiaz-gly-betathiobe 2567: phhs-oxadiaz-bala-beta3quin 2568: ibhs-25thiaz-gly-betaph 2569: phhs-25thiaz-gly-betampy 2570: ibhs-nme35pyr-gly-betabdimo D 2571: 2py-25methiaz-hphe-psdap 2572: phhs-ithiadiaz-gly-betahni 2573: bhs-nme35pyr-ala-betafphe 2574: 2 py-52thiaz-ala-betameph 2575: gua-24thiaz-gly-betafph 2576: ibhs-24thioph-bala-beta4bph 2577: bhs-24thiaz-bala-betaheph 2578: ibhs-25methiaz-gly-betaph 2579: phhs-nme35pyr-gly-betahcbph 2580: phhs-ithiadiaz-bala-betah35dc 2581: bhs-oxadiaz-bala-beta23meoph 2582: bim-25thiaz-gly-betaibph 2583: tolhs-25methiaz-bala-beta34dcph 2584: tolhs-24thioph-gly-zdapee 2585: tolhs-oxadiaz-gly-betahmo 2586: 4 pmhs-24oxaz-gly-betameph 2587: ibhs-ithiadiaz-bala-betafbph 2588: bhs-oxadiaz-bala-betaftrif -96 2589: gua-24oxaz-gly-betafu2 2590: tolhs-me24thiaz-gly-betadcph 2591: bhs-25thiaz-bala-betathiome 2592: impy-25oxaz-gly-betameph 5 2593: ibhs-25thiaz-bala-betafbph 2594: tolhs-24thiaz-bala-betaipro 2595: tolhs-25oxaz-bala-betapytb 2596: bim-me24thioph-leu-betapy 2597: tolhs-24thioph-gly-betaphethio 0 2598: 2py-25thioph-gly-psdap 2599: bhs-25thiaz-gly-betahmo 2600: tolhs-oxadiaz-bala-aspaba 2601: bhs-oxadiaz-leu-zdap 2602: hs-24thiaz-bala-betapy 5 2603: bhs-25thiaz-gly-betaoxope 2604: bhs-24thioph-bala-betathioph 2605: tolhs-ithiadiaz-bala-betabpy 2606: phhs-ithiadiaz-gly-betamethi 2607: phhs-24thiaz-gly-betatrif 3 2608: ibhs-nme35pyr-gly-betahmph 2609: phhs-25oxaz-bala-betacbph 2610: tolhs-25thiaz-gly-asppha 2611: bhs-25thiaz-bala-betahc 2612: tolhs-25thiaz-gly-betaph 2613: bhs-ithiadiaz-gly-zdapee 2614: bhs-25oxaz-bala-betamesu 2615: bhs-nme35pyr-gly-betahc 2616: tolhs-me25thiaz-gly-betapy 2617: bhs-oxadiaz-bala-betafph 2618: bim-nme35pyr-leu-betadcph 2619: tolhs-nme35pyr-bala-betamesu 2620: dhim-25thiaz-gly-betameph 2621: tolhs-me25thioph-ala-betapy 2622: ibhs-oxadiaz-bala-betaamibe 2623: impy-24thiaz-gly-betabthioph 2624: ibhs-25oxaz-bala-betaph 2625: bhs-25methiaz-gly-betapych -97 2626: bhs-25methiaz-gly-betambiph 2627: tolhs-25oxaz-gly-betadtrif 2628: bhs-25methiaz-nmgly-betadmph 2629: bhs-25thiaz-ala-betabpy 5 2630: ibhs-25oxaz-gly-betacthioph 2631: 2py-24thioph-gly-betacthioph 2632: bhs-24thioph-gly-betadcphee 2633: ibhs-25oxaz-gly-betadbph 2634: phhs-24thiaz-gly-betapym 0 2635: tolhs-nme35pyr-bala-betathiome 2636: bhs-ithiadiaz-ala-betadmph 2637: bhs-25thiaz-bala-betahmo 2638: bhs-25methiaz-nmgly-betahph 2639: tolhs-nme35pyr-gly-betameph 5 2640: ibhs-25methiaz-gly-betaomebendi 2641: bim-25oxaz-bala-beta4bph 2642: 2py-24thiaz-gly-betainyl 2643: bhs-ithiadiaz-bala-betaipr 2644: bhs-25thiaz-bala-betahdbph 2645: ibhs-25oxaz-gly-betahcbph 2646: tolhs-24thiaz-bala-betaibph 2647: 2py-25fur-gly-psdap 2648: phhs-25thiaz-bala-betaph 2649: bhs-24thiaz-gly-betapy 2650: ibhs-nme35pyr-bala-betabthioph 2651: tolhs-ithiadiaz-gly-betainyl 2652: dhpyrr-42nmeim-gly-zdap 2653: bhs-nme35pyr-gly-csdap 2654: gua-25thiaz-gly-betatos 2655: bhs-24thioph-gly-betatbuph 2656: ibhs-25oxaz-bala-betatbuph 2657: bhs-25thiaz-bala-betabenfu 2658: ibhs-nme35pyr-gly-betapy 2659: 2py-26py-gly-ibsdap 2660: 2py-24thiaz-bala-aspibua 2661: bhs-oxadiaz-gly-betabediox 2662: phhs-nme35pyr-bala-betafu2 -98 2663: bhs-thiadiaz-ala-betadcph 2664: bhs-oxadiaz-bala-betaheph 2665: bhs-25thiaz-gly-beta34meoph 2666: bhs-25methiaz-bala-betadmph 5 2667: bhs-25thiaz-bala-betaftrif 2668: ibhs-24oxaz-gly-zdap 2669: tolhs-ithiadiaz-bala-betah35dc 2670: 2py-24thiaz-bala-betafluo 2671: agua-24thiaz-gly-betainyl 0 2672: bim-25methiaz-bala-aspaba 2673: bhs-25thiaz-gly-betahmph 2674: phhs-25thiaz-bala-betaet 2675: bhs-25thiaz-bala-psdapch 2676: phhs-oxadiaz-gly-betadcph 5 2677: 2 py-42nmeim-nmala-betapy 2678: ibhs-26py-gly-betainyl 2679: phhs-25methiaz-gly-ibsdap 2680: bim-42pym-ala-psdap 2681: phhs-24thiaz-bala-betahph D 2682: tolhs-24thioph-gly-betabdimo 2683: ibhs-25oxaz-bala-betatrif 2684: bhs-nme35pyr-ala-zdap 2685: bhs-25fur-bala-betapy 2686: phhs-24thioph-gly-betabnaphth 5 2687: tolhs-nme35pyr-bala-betathioph 2688: phhs-25methiaz-bala-betaamibe 2689: tolhs-24thiaz-bala-betafbph 2690: ibhs-oxadiaz-gly-psdaptb 2691: tolhs-nme35pyr-gly-suabu 2692: tolhs-25methiaz-gly-betabnaphth 2693: bhs-25oxaz-mngly-betabnaphth 2694: ibhs-25thiaz-bala-betapytb 2695: tolhs-nme35pyr-bala-psdapee 2696: 2py-24thioph-gly-betadcph 2697: sabhs-25thiaz-ala-betameph 2698: bhs-25methiaz-gly-betathio3 2699: ibhs-25methiaz-gly-psdaptb -99 2700: bhs-nme35pyr-gly-betapym 2701: ibhs-25thiaz-gly-ibsdap 2702: impy-25methiaz-bala-betaftrif 2703: tolhs-25methiaz-gly-betafluo 5 2704: ibhs-25oxaz-bala-betaoxope 2705: gua-26py-gly-betafbph 2706: bhs-nme35pyr-bala-betahb 2707: ibhs-nme35pyr-bala-betapyee 2708: bhs-24oxaz-bala-psdap 0 2709: bhs-25oxaz-bala-betahdbph 2710: phhs-25oxaz-bala-zdap 2711: phhs-25methiaz-gly-betah35dc 2712: ibhs-25thiaz-bala-betacph 12713: tolhs-25thiaz-gly-betaamibe 5 2714: bhs-ithiadiaz-bala-betahmo 2715: tolhs-24thiaz-gly-suabu 2716: phhs-nme35pyr-gly-betaol 2717: phhs-24thiaz-bala-betapbiph 2718: bhs-oxadiaz-nmgly-betadito ) 2719: tolhs-ithiadiaz-gly-betaanaphth 2720: tolhs-25thiaz-gly-busu2be 2721: bim-24im-ala-betadcph 2722: ibhs-25thiaz-gly-betahmofu 2723: tolhs-oxadiaz-bala-betaomebendi 2724: bhs-ithiadiaz-gly-betadtrif 2725: ibhs-25methiaz-gly-betathioph 2726: phhs-25methiaz-bala-betahdbph 2727: bhs-nme35pyr-bala-betaol 2728: gua-26py-gly-betahc 2729: ibhs-25oxaz-bala-beta34meoph 2730: bim-25methiaz-bala-betahcbph 2731: phhs-nme35pyr-bala-betafph 2732: tolhs-25oxaz-bala-betaet 2733: 2py-nme35pyr-gly-betadcph 2734: tolhs-oxadiaz-gly-betaol 2735: bhs-24im-ala-zdap 2736: 2py-35thioph-gly-betadcph -100 2737: tolhs-25methiaz-gly-psdapee 2738: impy-25methiaz-bala-psdap 2739: ibhs-25methiaz-bala-betabediox 2740: tolhs-nme35pyr-bala-betaphethioa 5 2741: tolhs-ithiadiaz-gly-betahbcph 2742: thazep-24thioph-bala-zdap 2743: dhim-25py-gly-betameph 2744: 2py-25fur-gly-betapy 2745: impy-42nmeim-gly-betabmph 0 2746: tolhs-24thioph-gly-betacbph 2747: phhs-oxadiaz-bala-betaftrif 2748: tolhs-25thiaz-bala-betacph 2749: phhs-24thiaz-bala-betadito 2750: bhs-25fur-ala-betapy 5 2751: ibhs-25oxaz-gly-betahb 2752: tolhs-24thiaz-bala-zdapee 2753: bhs-25oxaz-gly-betahmo 2754: gua-24thiaz-gly-betamethioph 2755: nmhs-24thiaz-gly-betapy D 2756: phhs-25thiaz-gly-betafph 2757: tolhs-25oxaz-gly-betadmoph 2758: phhs-oxadiaz-bala-betaet 2759: bhs-24thiaz-gly-psdapee 2760: ibhs-24thiaz-bala-betabediox 2761: gua-24thiaz-gly-betafu3 2762: tolhs-nme35pyr-bala-betaphethio 2763: ibhs-24thioph-gly-psdap 2764: tolhs-me24oxaz-leu-beta34meoph 2765: 2py-24thioph-bala-aspaba 2766: bim-me24oxaz-leu-psdap 2767: bhs-nme35pyr-bala-betamesu 2768: bhs-thiadiaz-gly-zdap 2769: 2py-oxadiaz-ala-zdap 2770: bim-25methiaz-gly-betapbiph 2771: ibhs-24thioph-gly-betadcphee 2772: tolhs-nme35pyr-bala-betahdcph 2773: bhs-me24thioph-gly-betadcph -101 2774: phhs-25thiaz-bala-zdapch 2775: bhs-25thiaz-gly-betapych 2776: bhs-ithiadiaz-bala-betahdbph 2777: impy-24thiaz-nmgly-psdap 5 2778: bim-25oxaz-bala-betal 3bendi 2779: bim-oxadiaz-bala-betapy 2780: tolhs-24thiaz-bala-betahdcph 2781: 2py-nme35pyr-ala-psdap 2782: ibhs-25thiaz-gly-betadtrif D 2783: phhs-25thiaz-gly-betahbcph 2784: ibhs-oxadiaz-bala-zdapch 2785: dhim-26py-hphe-zdap 2786: phhs-nme35pyr-gly-betahbcph 2787: bhs-25thiaz-bala-betafluo 5 2788: ibhs-oxadiaz-gly-beta3quin 2789: 2py-35fur-bala-betadcph 2790: 2py-me25oxaz-gly-betadcph 2791: bhs-24thiaz-gly-betaipr 2792: bhs-25methiaz-bala-betabediox 2793: ibhs-ithiadiaz-gly-betaph 2794: phhs-25thiaz-bala-aspibua 2795: tolhs-oxadiaz-bala-betabdimo 2796: 2py-me24thiaz-ala-betapy 2797: impy-25methiaz-ala-betapy 2798: phhs-nme35pyr-bala-betabnaphth 2799: bim-me25oxaz-leu-betapy 2800: gua-me24thiaz-gly-betapy 2801: 2py-24im-gly-betapy 2802: bhs-25thiaz-bala-betapbiph 2803: bhs-24thioph-bala-ibsdap 2804: 2py-35thioph-leu-betapy 2805: bhs-25thiaz-ala-beta3quin 2806: ibhs-24thioph-bala-csdap 2807: bhs-53pyrazo-bala-zdap 2808: bhs-42nmeim-gly-betapy 2809: phhs-25oxaz-gly-betathioph 2810: ibhs-25methiaz-gly-betabpy - 102 2811: ibhs-24thiaz-bala-betapyee 2812: bhs-25thiaz-nmgly-betaipro 2813: bhs-25methiaz-bala-betampy 2814: bhs-24thioph-bala-betamesu 5 2815: bim-me24oxaz-bala-zdap 2816: bhs-25methiaz-gly-betaph 2817: bim-25thiaz-gly-zdap 2818: bhs-nme35pyr-gly-betatbuph 2819: bhs-25oxaz-ala-betadhbfu 0 2820: ibhs-ithiadiaz-bala-betaphethioa 2821: bhs-oxadiaz-gly-betathiome 2822: phhs-24thioph-bala-betabediox 2823: bhs-25thiaz-bala-betathioph 2824: phhs-oxadiaz-bala-betaipr 5 2825: bim-me25thioph-gly-betadcph 2826: bhs-25oxaz-gly-betameph 2827: bhs-oxadiaz-gly-betal 3bendi 2828: ibhs-oxadiaz-gly-zdapee 2829: 2py-me24thioph-bala-psdap D 2830: bhs-25thiaz-bala-betacbph 2831: 2py-me25oxaz-leu-betadcph 2832: tolhs-25thiaz-bala-betahcbph 2833: ibhs-25oxaz-bala-betabdimo 2834: 2py-25thioph-ala-betainyl 5 2835: bhs-oxadiaz-bala-betathioph 2836: bhs-25methiaz-gly-betaipro 2837: bhs-24thioph-ala-betapy 2838: ibhs-25thiaz-gly-betafluo 2839: 2py-24oxaz-gly-zdap 2840: phhs-oxadiaz-bala-betadcphee 2841: 2py-24thiaz-ala-betadcph 2842: ibhs-24thiaz-gly-betaheph 2843: bhs-me25oxaz-ala-betapy 2844: ibhs-nme35pyr-bala-betaomebendi 2845: bhs-thiadiaz-gly-betapy 2846: bhs-25thiaz-gly-betadhbfu 2847: dhim-24oxaz-gly-betapy -103 2848: gua-24thiaz-gly-betafluo 2849: bhs-thiadiaz-bala-zdap 2850: ibhs-25oxaz-gly-betahni 2851: tolhs-25thiaz-bala-betahc 5 2852: bhs-nme35pyr-ala-ibsdap 2853: bhs-oxadiaz-gly-betabdimo 2854: phhs-me24thiaz-leu-betaph 2855: tolhs-25thiaz-bala-betathioph 2856: bhs-25oxaz-bala-betatrif 0 2857: ibhs-24thiaz-gly-betamesu 2858: bim-25thiaz-ala-betainyl 2859: bhs-me25thiaz-leu-zdap 2860: tolhs-me24thiaz-bala-betadcph 2861: ibhs-25oxaz-gly-betacph 5 2862: bim-26py-ala-zdap 2863: bhs-oxadiaz-nmgly-betacph 2864: ibhs-25methiaz-gly-beta3quin 2865: 2py-me25thiaz-gly-zdap 2866: 2pmhs-24thioph-bala-betahph 0 2867: impy-25methiaz-bala-betafu3 2868: phhs-nme35pyr-gly-betamesu 2869: ibhs-oxadiaz-gly-betaphethioa 2870: tolhs-24thioph-bala-betathioph 2871: ibhs-25oxaz-gly-psdaptb 5 2872: bim-25methiaz-gly-betapy 2873: 2py-25oxaz-ala-zdap 2874: phhs-24thiaz-gly-betadtrif 2875: bhs-oxadiaz-bala-betacthioph 2876: 2py-nme35pyr-gly-aspbzla 2877: ibhs-25oxaz-gly-betafu2 2878: ibhs-24thioph-bala-betahb 2879: bim-me25oxaz-bala-zdap 2880: bim-42nmeim-bala-beta34meoph 2881: bim-me24thiaz-gly-betapy 2882: phhs-25methiaz-gly-csdap 2883: bhs-ithiadiaz-gly-betapym 2884: phhs-24thioph-bala-betacbph -104 2885: bhs-25oxaz-gly-betafu3 2886: 2py-24im-leu-psdap 2887: bhs-me25thioph-ala-betadcph 2888: tolhs-25thiaz-gly-betadcphee 5 2889: bhs-25oxaz-bala-ibsdap 2890: 2py-me24thiaz-bala-zdap 2891: bhs-me25thioph-gly-betaph 2892: phhs-nme35pyr-bala-betaet 2893: bim-24thiaz-gly-betaanaphth 0 2894: bhs-24thiaz-ala-betathioph 2895: bhs-53pyrazo-leu-zdap 2896: 2py-42nmeim-bala-betahmph 2897: 2py-me25oxaz-gly-betapy 2898: tolhs-24thioph-gly-betamethi 5 2899: bhs-24thioph-bala-betadbph 2900: ibhs-25thiaz-gly-beta35dbph 2901: phhs-24thioph-bala-aspbzla 2902: tolhs-24thioph-bala-beta35dbph 2903: bhs-nme35pyr-bala-betaipr D 2904: bim-me24thiaz-bala-beta34meoph 2905: ibhs-24thioph-gly-betamesu 2906: 2py-me25thioph-gly-betaph 2907: dhim-25thioph-ala-psdap 2908: impy-24thiaz-ala-betapy 5 2909: tolhs-nme35pyr-gly-betahbcph 2910: tolhs-oxadiaz-gly-betacthioph 2911: bhs-nme35pyr-gly-betahph 2912: tolhs-25oxaz-gly-betaipro 2913: phhs-25oxaz-bala-betahni P 2914: ibhs-25methiaz-bala-csdap 2915: 2py-25thiaz-ala-psdap 2916: tolhs-me24oxaz-gly-psdap 2917: ibhs-ithiadiaz-gly-betaftrif 2918: phhs-nme35pyr-gly-betadtrif 2919: 2pmhs-25methiaz-bala-betal 3bendi 2920: bhs-oxadiaz-nmgly-beta34dcph 2921: bim-25thiaz-bala-betaipro -105 2922: phhs-oxadiaz-gly-betabthioph 2923: bhs-24thioph-gly-betahmo 2924: phhs-24thioph-bala-betahmofu 2925: tolhs-me24thiaz-leu-betaph 5 2926: tolhs-25thiaz-bala-betahbcph 2927: ibhs-ithiadiaz-gly-betal 3bendi 2928: tolhs-ithiadiaz-gly-suabu 2929: bim-26py-ala-betapy 2930: ibhs-24thioph-bala-betacthioph 0 2931: ibhs-25thiaz-gly-betaet 2932: phhs-nme35pyr-gly-betaoxope 2933: bim-35fur-gly-betapy 2934: phhs-oxadiaz-gly-betafu2 2935: bhs-52thiaz-ala-betadcph 5 2936: tolhs-25methiaz-bala-betahmph 2937: ibhs-25thiaz-bala-betaftrif 2938: tolhs-oxadiaz-bala-zdap 2939: bim-me25thioph-ala-beta34meoph 2940: gua-42pym-gly-beta35dbph 0 2941: gua-26py-gly-betabpy 2942: 4pmhs-25thiaz-gly-zdap 2943: tolhs-oxadiaz-gly-betaphethioa 2944: tolhs-nme35pyr-gly-betatbuph 2945: gua-26py-gly-betahbcph 5 2946: bhs-25thiaz-bala-betacthioph 2947: ibhs-24thioph-bala-suabu 2948: ibhs-24thiaz-gly-betacph 2949: ibhs-nme35pyr-gly-betaftrif 2950: 2py-me25thiaz-gly-betadcph 2951: 2py-24oxaz-ala-zdap 2952: agua-24thiaz-gly-betadcph 2953: impy-42nmeim-bala-betahb 2954: bhs-25oxaz-bala-betabdimo 2955: phhs-nme35pyr-bala-zdap 2956: bhs-me24thiaz-leu-zdap 2957: tolhs-24thiaz-bala-beta23meoph 2958: bhs-triaz-gly-betameph - 106 2959: bhs-ithiadiaz-gly-betathio3 2960: ibhs-nme35pyr-bala-betafph 2961: gua-24thiaz-gly-betahni 2962: bhs-25thiaz-nmgly-betacthioph 5 2963: tolhs-25oxaz-bala-betadcphch 2964: phhs-25thiaz-bala-betafu3 2965: tolhs-ithiadiaz-bala-zdaptb 2966: ibhs-ithiadiaz-gly-betaipro 2967: bhs-25oxaz-ala-betaoxaz 0 2968: phhs-ithiadiaz-gly-betaipr 2969: bhs-nme35pyr-bala-betabenfu 2970: 2py-52thiaz-ala-psdap 2971: bhs-24thioph-gly-betabpy 2972: dhthi-25methiaz-bala-betadcph 5 2973: ibhs-24thioph-gly-betaomebendi 2974: tolhs-nme35pyr-gly-betadcphch 2975: bhs-25thiaz-bala-betaanaphth 2976: bhs-25methiaz-ala-betaoxaz 2977: tolhs-25methiaz-bala-betadmph 0 2978: 2py-42nmeim-gly-betadcph 2979: bhs-35thioph-gly-betadcph 2980: phhs-nme35pyr-bala-betahmofu 2981: ibhs-25methiaz-gly-betahmph 2982: tolhs-ithiadiaz-gly-betapym 5 2983: bhs-ithiadiaz-gly-betadcphee 2984: bim-53pyrazo-bala-betadcph 2985: tolhs-25oxaz-bala-betabph 2986: ibhs-25oxaz-gly-betahph 2987: tolhs-25oxaz-gly-betampy 2988: ibhs-oxadiaz-bala-zdaptb 2989: bhs-oxadiaz-bala-betafbph 2990: tolhs-25oxaz-gly-betaipr 2991: bim-me24thioph-bala-beta34meoph 2992: bhs-42pym-gly-betadcph i 2993: phhs-25methiaz-bala-betadtrif 2994: 2py-25oxaz-gly-betaipr 2995: phhs-oxadiaz-bala-betacbph -107 2996: ibhs-24thioph-gly-betaoxaz 2997: tolhs-ithiadiaz-gly-betaftrif 2998: bhs-nme35pyr-nmgly-betaoxaz 2999: bhs-25thiaz-ala-betabnapbth 5 3000: phhs-24thioph-gly-betacbph 3001: bhs-me25thioph-leu-betapy 3002: bhs-me24thiaz-ala-betadcph 3003: ibhs-25thiaz-bala-betaol 3004: ibhs-25methiaz-gly-betabediox 0 3005: phhs-25thiaz-gly-betaipr 3006: bim-24oxaz-bala-zdap 3007: bhs-25oxaz-bala-zdapch 3008: 3pmhs-25thiaz-bala-betapy 3009: tolhs-25methiaz-bala-betafluo 5 3010: bhs-ithiadiaz-gly-betapbiph 3011: phhs-24thiaz-gly-beta23meoph 3012: bhs-nme35pyr-gly-betadhbfu 3013: ibhs-25oxaz-bala-aspaba 3014: thpym-24thiaz-gly-betadcph D 3015: bhs-oxadiaz-gly-betafbph 3016: 2py-25thiaz-leu-psdap 3017: 2py-53pyrazo-ala-psdap 3018: ibhs-nme35pyr-bala-beta23meoph 3019: tolhs-24thioph-gly-betahni 5 3020: ibhs-24thioph-gly-betamethioph 3021: bhs-25methiaz-bala-betahc 3022: phhs-oxadiaz-bala-betamethioph 3023: ibhs-25methiaz-bala-aspaba 3024: bim-24thioph-gly-betaomebendi 3025: tolhs-ithiadiaz-gly-betapytb 3026: bim-25methiaz-gly-betatrif 3027: 2py-me25thiaz-gly-betaph 3028: phhs-25oxaz-bala-betabpy 3029: phhs-nme35pyr-gly-betahph 3030: tolhs-ithiadiaz-gly-betabmph 3031: tolhs-25methiaz-gly-betahni 3032: phhs-25methiaz-bala-betaomebendi - 108 3033: tolhs-oxadiaz-gly-betamethi 3034: ibhs-24thiaz-bala-csdap 3035: ibhs-ithiadiaz-gly-betaomebendi 3036: tolhs-oxadiaz-bala-betamesu 5 3037: bhs-24thioph-gly-psdapch 3038: phhs-24thioph-gly-zdap 3039: 2py-25oxaz-bala-psdap 3040: bhs-me24thiaz-ala-betapy 3041: tolhs-24thioph-bala-beta34dcph 0 3042: 2py-25thioph-leu-betadcph 3043: bhs-25methiaz-gly-betafluo 3044: tolhs-25oxaz-gly-betahmph 3045: tolhs-nme35pyr-bala-betacbph 3046: ibhs-25thiaz-bala-betahni 5 3047: sabhs-25methiaz-gly-psdap 3048: ibhs-ithiadiaz-gly-zdapee 3049: ibhs-nme35pyr-gly-betafph 3050: bim-25thioph-bala-betadcph 3051: phhs-25oxaz-bala-betahph D 3052: phhs-nme35pyr-bala-aspaba 3053: ibhs-24thioph-gly-beta4bph 3054: bhs-25thiaz-gly-betatrif 3055: bhs-25thiaz-bala-betathio3 3056: tolhs-ithiadiaz-gly-betathio3 5 3057: tolhs-ithiadiaz-bala-zdap 3058: bim-24thiaz-bala-betatos 3059: tolhs-25oxaz-gly-suabu 3060: bhs-24thioph-bala-betapbiph 3061: ibhs-oxadiaz-bala-betabnaphth 3062: bim-42nmeim-gly-zdap 3063: phhs-me25thiaz-leu-betapy 3064: bhs-25methiaz-gly-betamesu 3065: bhs-me25thiaz-gly-psdap 3066: tolhs-me25oxaz-bala-zdap 3067: bim-53pyrazo-ala-betapy 3068: phhs-ithiadiaz-bala-beta34dcph 3069: ibhs-25thiaz-gly-betapyee -109 3070: tolhs-25thiaz-bala-betaoxope 3071: ibhs-25methiaz-gly-betampy 3072: tolhs-24thiaz-gly-betaoxope 3073: bhs-oxadiaz-gly-beta34meoph 5 3074: tolhs-ithiadiaz-bala-betaoxaz 3075: phhs-24thioph-gly-betadcphch 3076: 2py-me24thiaz-bala-psdap 3077: bhs-25thiaz-ala-betainyl 3078: phhs-25thiaz-gly-betahdcph 0 3079: phhs-25thiaz-gly-betah35dc 3080: tolhs-25methiaz-gly-betathio3 3081: 2py-me24thioph-gly-betaph 3082: bhs-24thioph-bala-betaoxope 3083: bhs-24thiaz-bala-aspbzla 5 3084: phhs-25thiaz-bala-betamethioph 3085: tolhs-25thiaz-bala-betadcphee 3086: bhs-24thioph-leu-betadcph 3087: ibhs-24thioph-gly-ibsdap 3088: phhs-nme35pyr-gly-betaibph 0 3089: phhs-25thiaz-bala-betahdbph 3090: bgua-24thiaz-gly-psdap 3091: bhs-25oxaz-gly-betadcph 3092: phhs-nme35pyr-bala-betaol 3093: tolhs-ithiadiaz-bala-betaibph 5 3094: phhs-25thiaz-bala-betacph 3095: ibhs-nme35pyr-bala-betabediox 3096: tolhs-ithiadiaz-gly-betapych 3097: bhs-nme35pyr-gly-psdap 3098: phhs-25thiaz-gly-betahb D 3099: phhs-24thiaz-gly-betafu2 3100: tolhs-ithiadiaz-bala-betadcph 3101: ibhs-25oxaz-gly-betabph 3102: gua-24oxaz-gly-betapym 3103: tolhs-25thiaz-bala-betabediox 5 3104: bim-thiadiaz-bala-psdap 3105: tolhs-24thiaz-bala-betamethi 3106: bhs-24thioph-gly-betaol -110 3107: bim-25thioph-bala-psdap 3108: tolhs-25oxaz-gly-aspbzla 3109: tolhs-24thioph-bala-betaamibe 3110: bhs-me24thiaz-gly-betapy 5 3111: ibhs-oxadiaz-bala-betadmoph 3112: tolhs-25thiaz-bala-betabmph 3113: phhs-25thiaz-bala-betabmph 3114: phhs-25oxaz-bala-beta34meoph 3115: phhs-25methiaz-gly-asppha 0 3116: bhs-25methiaz-bala-betatrif 3117: bim-me24thiaz-leu-psdap 3118: ibhs-25thiaz-gly-betabdimo 3119: gua-25oxaz-gly-zdap 3120: bhs-25oxaz-gly-betahmph 5 3121: bim-42pym-gly-betapy 3122: ibhs-25thiaz-gly-psdaptb 3123: bhs-25oxaz-bala-beta4bph 3124: bhs-ithiadiaz-gly-betahcbph 3125: ibhs-25thiaz-bala-zdapch 0 3126: ibhs-nme35pyr-bala-busu2be 3127: bhs-24oxaz-ala-betadcph 3128: bhs-25methiaz-gly-betapyee 3129: ibhs-24thiaz-bala-betabph 3130: phhs-ithiadiaz-bala-betabnaphth 5 3131: ibhs-ithiadiaz-bala-zdapch 3132: bhs-nme35pyr-nmgly-betaipro 3133: bhs-25thiaz-bala-csdap 3134: tolhs-ithiadiaz-bala-betathiobe 3135: bhs-24thiaz-gly-betadcph D 3136: dhim-25thiaz-gly-betadcph 3137: tolhs-25oxaz-bala-betatrif 3138: impy-24thioph-ala-betapy 3139: phhs-25methiaz-gly-betathio3 3140: gua-24thiaz-gly-betapyr 5 3141: impy-24thiaz-bala-betaftrif 3142: phhs-nme35pyr-bala-betahni 3143: 2py-42nmeim-bala-psdap - 111 3144: ibhs-25thiaz-bala-asppha 3145: phhs-24thioph-bala-psdapch 3146: tolhs-24thiaz-gly-betadmph 3147: bim-24thiaz-gly-betadbph 5 3148: bhs-42pym-gly-betapy 3149: phhs-25methiaz-bala-betafluo 3150: 2py-35thioph-ala-zdap 3151: tolhs-24thiaz-bala-betaoxaz 3152: phhs-24thioph-bala-betatos 0 3153: tolhs-oxadiaz-bala-beta23meoph 3154: bhs-ithiadiaz-nmgly-betabpy 3155: tolhs-nme35pyr-bala-betameph 3156: tolhs-ithiadiaz-gly-betacph 3157: bhs-24oxaz-ala-betapy 5 3158: 2py-24thioph-bala-zdap 3159: bim-25thiaz-bala-betahcbph 3160: phhs-25thiaz-gly-betathiobe 3161: bhs-24thioph-bala-busu2be 3162: phhs-me25oxaz-bala-psdap 0 3163: phhs-25thiaz-gly-betatos 3164: bhs-25thiaz-nmgly-betabnaphth 3165: tolhs-24thioph-gly-betadcphtb 3166: ibhs-ithiadiaz-gly-betacph 3167: phhs-ithiadiaz-bala-betahph 5 3168: ibhs-ithiadiaz-bala-betaet 3169: phhs-25methiaz-bala-ibsdap 3170: tolhs-25methiaz-gly-betahdcph 3171: ibhs-25oxaz-bala-betahmofu 3172: bhs-24thioph-gly-betahmofu 3173: 2py-me25oxaz-bala-betadcph 3174: bhs-nme35pyr-bala-betacthioph 3175: ibhs-24thioph-bala-betaipro 3176: bim-25methiaz-gly-betahmph 3177: sabhs-26py-gly-betainyl 3178: phhs-ithiadiaz-gly-psdapch 3179: bim-me25oxaz-bala-betaph 3180: phhs-oxadiaz-bala-betaphethioa -112 3181: tolhs-ithiadiaz-bala-betainyl 3182: bhs-24thioph-nmgly-betadhbfu 3183: phhs-25methiaz-gly-betaol 3184: phhs-ithiadiaz-bala-betabph 5 3185: 2py-me25thioph-ala-zdap 3186: bim-ithiadiaz-bala-aspaba 3187: dhim-26py-nmgly-zdap 3188: 2py-24thioph-ala-betapy 3189: tolhs-25oxaz-gly-betafu3 0 3190: tolhs-25oxaz-bala-betahdcph 3191: bhs-ithiadiaz-gly-betatbuph 3192: 2py-25methiaz-bala-betahni 3193: bhs-24thiaz-ala-betaipro 3194: bhs-24thiaz-gly-aspaba 5 3195: ibhs-nme35pyr-bala-aspibua 3196: bhs-25methiaz-bala-betabmph 3197: bhs-25methiaz-ala-betamesu 3198: bhs-nme35pyr-bala-betadcph 3199: impy-42nmeim-bala-betapy ) 3200: ibhs-25methiaz-bala-betadbph 3201: ibhs-ithiadiaz-bala-asppha 3202: tolhs-25methiaz-bala-betatrif 3203: ibhs-ithiadiaz-bala-betapym 3204: bhs-nme35pyr-nmgly-betathioph 3205: tolhs-me25oxaz-bala-psdap 3206: tolhs-24thioph-bala-betatbuph 3207: bhs-ithiadiaz-bala-busu2be 3208: tolhs-oxadiaz-bala-aspibua 3209: phhs-ithiadiaz-gly-betafphe 3210: ibhs-25methiaz-gly-betahdbph 3211: bhs-me24oxaz-gly-psdap 3212: bhs-46pym-ala-zdap 3213: bim-25thioph-ala-betainyl 3214: phhs-24thioph-gly-betampy 3215: gua-26py-gly-betaftrif 3216: ibhs-25thiaz-bala-betabmph 3217: ibhs-oxadiaz-gly-betadcph -113 3218: 2pmhs-25methiaz-bala-betabmph 3219: bim-ithiadiaz-gly-asppha 3220: phhs-25methiaz-gly-beta34dcph 3221: tolhs-24thioph-gly-betahcbph 5 3222: bhs-ithiadiaz-nmgly-betafphe 3223: ibhs-ithiadiaz-gly-betaphethio 3224: phhs-25oxaz-bala-zdapch 3225: ibhs-oxadiaz-gly-betamesu 3226: tolhs-oxadiaz-bala-betadcphee 0 3227: tolhs-ithiadiaz-gly-aspaba 3228: impy-24thioph-bala-busu2be 3229: bhs-24thioph-leu-zdap 3230: ibhs-oxadiaz-bala-betaftrif 3231: gua-26py-gly-betapbiph 5 3232: ibhs-oxadiaz-gly-betapytb 3233: bim-25fur-gly-betadcph 3234: bhs-24thiaz-gly-psdaptb 3235: ibhs-ithadiaz-gly-beta34meoph 3236: tolhs-25thiaz-bala-betadcphch D 3237: phhs-24thioph-bala-betahb 3238: 2py-25thiaz-gly-psdap 3239: tolhs-24thiaz-gly-betahdbph 3240: ibhs-nme35pyr-gly-psdap 3241: bhs-25thiaz-leu-betameph 5 3242: bhs-25thiaz-bala-betafphe 3243: ibhs-oxadiaz-gly-beta34meoph 3244: phhs-me24oxaz-ala-zdap 3245: ibhs-ithiadiaz-gly-betabpy 3246: bhs-ithiadiaz-gly-betamethi 3247: phhs-25thiaz-bala-csdap 3248: bhs-25thiaz-met-betadcph 3249: 2py-nme35pyr-bala-psdap 3250: bhs-25thiaz-gly-betatos 3251: bhs-25oxaz-gly-betaomebendi 3252: bhs-24thiaz-gly-betapyee 3253: ibhs-oxadiaz-bala-betafphe 3254: gua-24thiaz-nmgly-betapy -114 3255: ibhs-24thiaz-bala-psdapee 3256: 2py-25methiaz-bala-aspaba 3257: ibhs-25thiaz-gly-betabediox 3258: phhs-me24thiaz-leu-beta34meoph 5 3259: ibhs-25methiaz-bala-betabthioph 3260: ibhs-25oxaz-gly-betapych 3261: 2py-52thiaz-ala-betainyl 3262: tolhs-me24thioph-ala-zdap 3263: ibhs-24thioph-gly-betabmph 0 3264: bhs-25thiaz-gly-zdaptb 3265: phhs-24thioph-bala-ibsdap 3266: bhs-nme35pyr-gly-betahni 3267: bhs-25oxaz-gly-zdapch 3268: phhs-25oxaz-gly-betafu3 5 3269: phhs-25thiaz-bala-betadmoph 3270: bhs-oxadiaz-nmgly-betadmoph 3271: bhs-25methiaz-gly-betahbcph 3272: tolhs-25methiaz-bala-betabthioph 3273: bhs-oxadiaz-bala-zdapch 0 3274: gua-24oxaz-gly-betaamibe 3275: phhs-25thiaz-gly-betabpy 3276: bhs-24im-bala-psdap 3277: phhs-24thiaz-bala-asppha 3278: ibhs-ithiadiaz-gly-betadmoph 5 3279: tolhs-24thioph-bala-suabu 3280: bim-me24oxaz-bala-betadcph 3281: tolhs-oxadiaz-bala-betabph 3282: phhs-24thiaz-bala-betaipro 3283: bhs-oxadiaz-bala-betaipro 3284: phhs-25oxaz-bala-betadtrif 3285: ibhs-25oxaz-gly-betambiph 3286: bhs-nme35pyr-gly-aspibua 3287: bim-oxadiaz-leu-betapy 3288: bhs-oxadiaz-ala-betaanaphth 3289: 2py-25thiaz-ala-betainyl 3290: 2py-24thiaz-bala-suabu 3291: bhs-24thiaz-bala-betahni -115 3292: bhs-25methiaz-ser-betapy 3293: phhs-oxadiaz-gly-betaheph 3294: gua-24thiaz-gly-suabu 3295: tolhs-25methiaz-bala-betacph 5 3296: ibhs-25thiaz-gly-betapy 3297: ibhs-24thioph-bala-betatos 3298: thpym-24thiaz-gly-betahdcph 3299: tolhs-25methiaz-bala-aspibua 3300: thazep-25oxaz-gly-psdap 0 3301: tolhs-nme35pyr-bala-zdapch 3302: bhs-oxadiaz-gly-betaphethioa 3303: phhs-me24thioph-leu-betaph 3304: phhs-me25oxaz-gly-psdap 3305: tolhs-25methiaz-gly-betamethi 5 3306: ibhs-25oxaz-bala-betacbph 3307: bhs-25thiaz-leu-betapy 3308: ibhs-ithiadiaz-gly-betahdcph 3309: thpy-24oxaz-gly-betadcph 3310: phhs-25thiaz-bala-betathioph 0 3311: bim-ithiadiaz-gly-aspaba 3312: tolhs-ithiadiaz-bala-aspbzla 3313: bim-24thioph-ala-zdap 3314: ibhs-25oxaz-gly-betapyr 3315: bhs-24thioph-gly-betaipro 5 3316: bhs-24thiaz-bala-betaoxope 3317: bhs-nme35pyr-gly-betah35dc 3318: phhs-oxadiaz-bala-betapym 3319: tolhs-24thiaz-bala-betaheph 3320: ibhs-ithiadiaz-gly-betaheph 3321: phhs-24thioph-gly-betaomebendi 3322: ibhs-ithiadiaz-bala-betacthioph 3323: bhs-ithiadiaz-gly-betamesu 3324: nmhs-24thioph-gly-betadcph 3325: ibhs-24thiaz-bala-betatrif i 3326: bhs-oxadiaz-bala-betambiph 3327: bhs-oxadiaz-nmgly-betaipro 3328: bim-me24thioph-leu-beta34meoph -116 3329: 2pmhs-24thiaz-gly-betahbcph 3330: tolhs-24thiaz-gly-betapy 3331: ibhs-25oxaz-bala-betathiobe 3332: 2pmhs-42pym-gly-betapy 5 3333: phhs-25methiaz-bala-betaph 3334: phhs-oxadiaz-gly-betafphe 3335: tolhs-ithiadiaz-gly-betahmo 3336: bhs-25oxaz-nmgly-betathioph 3337: bhs-42nmeim-gly-suabu 0 3338: ibhs-24thiaz-bala-betah35dc 3339: bgua-24thioph-gly-betameph 3340: phhs-ithiadiaz-gly-betatos 3341: tolhs-oxadiaz-gly-beta34dcph 3342: ibhs-25methiaz-bala-betaheph 5 3343: bim-25fur-ala-zdap 3344: bim-24thioph-bala-betadcph 3345: ibhs-25oxaz-bala-betaftrif 3346: ibhs-oxadiaz-gly-beta34dcph 3347: tolhs-25thiaz-gly-betamesu 3 3348: bhs-oxadiaz-bala-betapy 3349: impy-24thioph-bala-betaphethioa 3350: ibhs-24thioph-gly-betadcph 3351: bhs-ithiadiaz-gly-aspibua 3352: bhs-24oxaz-bala-zdap 5 3353: tolhs-25thiaz-gly-betapytb 3354: phhs-oxadiaz-bala-betabenfu 3355: tolhs-24thiaz-bala-betahcbph 3356: bim-25thiaz-bala-betacph 3357: ibhs-25methiaz-bala-betatbuph 3358: tolhs-25thiaz-bala-betabthioph 3359: phhs-ithiadiaz-bala-betathio3 3360: ibhs-24thioph-bala-busu2be 3361: 2py-53pyrazo-ala-betadcph 3362: tolhs-oxadiaz-gly-beta35dbph 3363: ibhs-ithiadiaz-bala-betahc 3364: phhs-oxadiaz-bala-betapytb 3365: phhs-oxadiaz-gly-betafbph -117 3366: tolhs-me24oxaz-gly-betadcph 3367: bhs-25oxaz-bala-betapytb 3368: phhs-24thiaz-gly-betahdbph 3369: bim-26py-ala-betainyl 5 3370: phhs-24thioph-gly-betambiph 3371: bhs-nme35pyr-gly-betambiph 3372: bhs-ithiadiaz-bala-betamesu 3373: tolhs-nme35pyr-gly-psdapch 3374: bhs-25oxaz-nmgly-betabpy 0 3375: tolhs-me24thioph-ala-betapy 3376: phhs-24thiaz-gly-betameph 3377: phhs-25oxaz-gly-betaol 3378: bim-24thioph-bala-betahc 3379: bhs-nme35pyr-ala-betabpy 5 3380: ibhs-24thiaz-gly-betadhbfu 3381: bhs-25oxaz-gly-betahbcph 3382: tolhs-me24oxaz-leu-betaph 3383: 4pmhs-26py-gly-betapy 3384: ibhs-25thiaz-bala-betahbcph D 3385: tolhs-24thiaz-bala-betadcph 3386: tolhs-oxadiaz-bala-betainyl 3387: tolhs-25methiaz-bala-psdap 3388: phhs-me24thioph-bala-betadcph 3389: phhs-oxadiaz-bala-betathio3 5 3390: phhs-24thioph-bala-asppha 3391: bhs-24thioph-bala-betainyl 3392: bhs-25oxaz-gly-betafluo 3393: ibhs-nme35pyr-bala-psdapee 3394: bim-me25oxaz-leu-betadcph 3395: tolhs-ithiadiaz-bala-betafu2 3396: phhs-25methiaz-gly-betabthioph 3397: bhs-24thiaz-bala-betafbph 3398: ibhs-nme35pyr-bala-betafluo 3399: bhs-ithiadiaz-nmgly-beta1 3bendi 3400: bhs-24thiaz-gly-betaol 3401: ibhs-oxadiaz-gly-suabu 3402: nmhs-42nmeimn-gly-psdap -118 3403: phhs-25methiaz-bala-asppha 3404: gua-26py-gly-beta34dcph 3405: phhs-ithiadiaz-bala-betadbph 3406: phhs-me25thioph-gly-psdap 5 3407: bhs-24thiaz-bala-betabediox 3408: bim-25thioph-ala-betadcph 3409: bhs-ithiadiaz-ala-ibsdap 3410: ibhs-25thiaz-bala-aspibua 3411: bhs-24thioph-bala-beta4bph D 3412: ibhs-ithiadiaz-bala-betabnaphth 3413: 2py-25methiaz-gly-betathio3 3414: bhs-ithiadiaz-gly-betampy 3415: phhs-nme35pyr-gly-betamethi 3416: ibhs-24thioph-bala-beta34meoph 5 3417: ibhs-25oxaz-bala-betafu3 3418: phhs-ithiadiaz-gly-betaimid 3419: tolhs-25oxaz-gly-betadcphch 3420: tolhs-24thioph-bala-betafbph 3421: ibhs-25thiaz-bala-betatbuph 3422: bhs-25oxaz-gly-psdaptb 3423: bim-me24thioph-bala-betaph 3424: bhs-24thiaz-gly-beta3quin 3425: bim-me24thiaz-leu-betadcph 3426: phhs-ithiadiaz-gly-betal 3bendi 3427: tolhs-25methiaz-gly-aspibua 3428: tolhs-24thiaz-gly-betadhbfu 3429: bhs-42pym-ala-betadcph 3430: ibhs-nme35pyr-bala-betacthoph 3431: bhs-25oxaz-gly-betaanaphth 3432: ibhs-ithiadiaz-gly-betatos 3433: ibhs-nme35pyr-bala-betadcph 3434: ibhs-nme35pyr-bala-betatos 3435: tolhs-nme35pyr-bala-betahbcph 3436: 2py-me25thioph-ala-betaph 3437: ibhs-oxadiaz-gly-busu2be 3438: bim-triaz-bala-zdap 3439: bhs-24thioph-gly-betampy -119 3440: bhs-35fur-bala-betapy 3441: bhs-me24thioph-leu-beta34meoph 3442: ibhs-25oxaz-bala-betaanaphth 3443: bhs-25oxaz-leu-zdap 5 3444: gua-24thiaz-gly-betadmoph 3445: bhs-ithiadiaz-bala-betacthioph 3446: bhs-25thiaz-gly-betapyr 3447: ibhs-ithiadiaz-gly-beta34dcph 3448: tolhs-oxadiaz-bala-betaheph 0 3449: tolhs-oxadiaz-gly-betapyee 3450: gua-24oxaz-gly-betambiph 3451: tolhs-24thioph-gly-betafu3 3452: tolhs-24thiaz-bala-zdaptb 3453: tolhs-ithiadiaz-gly-betaoxope 5 3454: phhs-nme35pyr-gly-betaftrif 3455: bhs-ithiadiaz-bala-betadcphtb 3456: bim-triaz-bala-psdap 3457: bhs-nme35pyr-gly-betapyr 3458: bhs-25oxaz-bala-betaipro 0 3459: tolhs-nme35pyr-gly-betabmph 3460: ibhs-24thiaz-bala-betadmph 3461: tolhs-24thiaz-gly-betaphethio 3462: agua-26py-gly-betadcph 3463: 2py-triaz-gly-psdap 5 3464: 2py-24thiaz-bala-betabnaphth 3465: tolhs-oxadiaz-bala-betaph 3466: ibhs-25methiaz-gly-aspaba 3467: bim-me24thiaz-gly-betaph 3468: bim-me24thioph-ala-betapy D 3469: ibhs-24thiaz-bala-betaanaphth 3470: bim-42nmeim-ala-betapy 3471: ibhs-24thioph-bala-betahni 3472: bhs-24thioph-bala-asppha 3473: ibhs-24thiaz-bala-betahph 5 3474: bhs-25oxaz-bala-betahc 3475: tolhs-24thioph-gly-betah35dc 3476: bim-me24thioph-ala-beta34meoph -120 3477: bim-me25oxaz-bala-beta34meoph 3478: tolhs-25thiaz-bala-aspaba 3479: ibhs-oxadiaz-bala-betampy 3480: bhs-35thioph-ala-betapy 5 3481: tolhs-24thioph-bala-betafph 3482: bhs-nme35pyr-bala-ibsdap 3483: 2pmhs-24thioph-bala-betapyr 3484: phhs-24thiaz-gly-betafphe 3485: bhs-25oxaz-bala-betacbph 0 3486: tolhs-24thioph-gly-zdaptb 3487: bim-me24thiaz-leu-betapy 3488: bim-ithiadiaz-leu-betapy 3489: ibhs-ithiadiaz-bala-beta34dcph 3490: bhs-oxadiaz-bala-csdap 5 3491: phhs-25methiaz-bala-aspbzla 3492: 2py-me24oxaz-gly-psdap 3493: bhs-24thioph-gly-csdap 3494: phhs-ithiadiaz-bala-betadcphch 3495: ibhs-nme35pyr-gly-asppha ) 3496: bhs-oxadiaz-gly-betaftrif 3497: bhs-25methiaz-bala-betabenfu 3498: gua-24thiaz-gly-betaomebendi 3499: bhs-me25thiaz-gly-beta34meoph 3500: bim-25methiaz-bala-betampy 5 3501: phhs-25oxaz-gly-betaphethio 3502: tolhs-24thiaz-gly-zdap 3503: bhs-nme35pyr-bala-betacph 3504: tolhs-nme35pyr-gly-betabdimo 3505: bhs-nme35pyr-bala-betadcphch 3506: bhs-25thiaz-bala-betabnaphth 3507: bhs-25thiaz-bala-betaph 3508: tolhs-oxadiaz-gly-betatrif 3509: 2py-me24oxaz-leu-beta34meoph 3510: tolhs-ithiadiaz-bala-betathiome 3511: tolhs-25thiaz-bala-betapych 3512: tolhs-25oxaz-gly-betabediox 3513: tolhs-25methiaz-bala-betapym - 121 3514: bhs-25thiaz-gly-betambiph 3515: phhs-ithiodiaz-bala-betaoxaz 3516: 2py-42oxaz-bala-betadcph 3517: bhs-nme35pyr-gly-psdapee 5 3518: gua-24oxaz-gly-betafph 3519: phhs-24thioph-bala-betafphe 3520: bhs-25thiaz-bala-betapytb 3521: phhs-24thiaz-bala-betadcphch 3522: phhs-25thiaz-bala-betapyr 0 3523: tolhs-nme35pyr-gly-psdaptb 3524: tolhs-nme35pyr-bala-suabu 3525: bhs-42oxaz-bala-betadcph 3526: phhs-25methiaz-gly-betapych 3527: impy-25methiaz-bala-betainyl 5 3528: phhs-25thiaz-gly-ibsdap 3529: phhs-25oxaz-gly-betabnaphth 3530: bhs-oxadiaz-gly-betatos 3531: tolhs-25thiaz-gly-betambiph 3532: bhs-25methiaz-bala-psdaptb 3533: impy-24thiaz-gly-betathiobe 3534: bhs-25methiaz-bala-betamethioph 3535: bhs-25thiaz-nmgly-betainyl 3536: bhs-ithiadiaz-bala-betadito 3537: gua-24thiaz-gly-betabenfu 3538: ibhs-24thiaz-bala-betadtrif 3539: phhs-me25thioph-leu-betapy 3540: phhs-me25thiaz-gly-betaph 3541: ibhs-ithiadiaz-gly-betabnaphth 3542: ibhs-25oxaz-gly-betahbcph 3543: bhs-25thiaz-nmgly-beta3quin 3544: impy-24thioph-gly-betahmofu 3545: bhs-24thioph-gly-betapym 3546: 2py-52thiaz-gly-zdap 3547: phhs-oxadiaz-bala-betaibph 3548: 2pmhs-25methiaz-bala-beta4bph 3549: tolhs-25methiaz-gly-betaet 3550: bhs-25thiaz-ala-betahmph - 122 3551: bhs-25thioph-leu-betapy 3552: bhs-25methiaz-gly-suabu 3553: phhs-oxadiaz-bala-suabu 3554: phhs-25thiaz-bala-psdap 5 3555: phhs-me24thioph-leu-psdap 3556: bim-24thioph-gly-betaibph 3557: ibhs-oxadiaz-gly-betapy 3558: tolhs-24thiaz-bala-betaanaphth 3559: phhs-oxadiaz-bala-betaoxope 0 3560: bhs-24thiaz-bala-betapyee 3561: ibhs-24thiaz-gly-betahb 3562: tolhs-oxadiaz-bala-betahdbph 3563: bhs-24thiaz-gly-betabph 3564: bhs-ithiadiaz-ala-beta34dcph 5 3565: ibhs-24thiaz-bala-betatbuph 3566: ibhs-24thiaz-gly-betaipro 3567: bhs-ithiadiaz-ala-betadcph 3568: bhs-25thiaz-bala-betafbph 3569: phhs-25oxaz-gly-zdapch 0 3570: ibhs-24thiaz-gly-betabediox 3571: ibhs-25methiaz-gly-betadmoph 3572: phhs-24thioph-gly-betaipr 3573: bhs-ithiadiaz-bala-betabph 3574: tolhs-nme35pyr-gly-psdapee 5 3575: bim-42oxaz-bala-psdap 3576: ibhs-25oxaz-bala-betafluo 3577: tolhs-nme35pyr-gly-betahmo 3578: bhs-25methiaz-bala-aspaba 3579: bhs-25thioph-gly-zdap 3580: phhs-25oxaz-gly-betadmph 3581: bhs-oxadiaz-bala-betapyr 3582: gua-26py-gly-betamethioph 3583: 2py-25thioph-bala-betapy 3584: bhs-oxadiaz-ala-betathioph 3585: bim-thiadiaz-bala-zdap 3586: bim-25oxaz-bala-betamethioph 3587: bhs-25methiaz-nmgly-betamesu - 123 3588: dhpyrr-26py-gly-betadcph 3589: 2py-me25thiaz-gly-beta34meoph 3590: phhs-oxadiaz-gly-betahcbph 3591: 2py-me25thioph-gly-beta34meoph 5 3592: phhs-25methiaz-gly-betaibph 3593: ibhs-nme35pyr-bala-betamesu 3594: ibhs-24thioph-bala-betabpy 3595: ibhs-24thioph-bala-betadcphee 3596: ibhs-oxadiaz-gly-betacthioph 0 3597: gua-24oxaz-gly-betathiome 3598: gua-42pym-gly-betaoxope 3599: 2py-25oxaz-gly-aspbzla 3600: bhs-oxadiaz-gly-betadhbfu 3601: phhs-25methiaz-bala-betacthioph 5 3602: bim-25methiaz-bala-betaipro 3603: ibhs-ithiadiaz-gly-betadito 3604: tolhs-nme35pyr-bala-betahdbph 3605: bim-me24thioph-gly-beta34meoph 3606: phhs-me24thioph-gly-betapy D 3607: bhs-35fur-leu-psdap 3608: ibhs-24thiaz-gly-betadmph 3609: dhim-24thiaz-gly-betainyl 3610: bhs-42oxaz-gly-betadcph 3611: ibhs-24thiaz-bala-betaet 3612: phhs-nme35pyr-gly-betahb 3613: gua-24thiaz-gly-betabpy 3614: 2py-52thiaz-gly-psdap 3615: tolhs-25methiaz-bala-suabu 3616: phhs-25oxaz-gly-betabdimo 3617: bhs-nme35pyr-nmgly-betadmph 3618: ibhs-oxadiaz-gly-betadmoph 3619: phhs-nme35pyr-gly-aspaba 3620: phhs-nme35pyr-bala-betamesu 3621: bhs-25thiaz-bala-betathiobe 3622: bhs-24thiaz-leu-psdap 3623: bhs-25thiaz-gly-betadtrif 3624: ibhs-25methiaz-gly-betapyee - 124 3625: bim-35thioph-gly-psdap 3626: bhs-25oxaz-gly-betadtrif 3627: bhs-oxadiaz-bala-betadcph 3628: bim-25thiaz-ala-betapy 5 3629: 2py-24thiaz-gly-asppha 3630: bhs-oxadiaz-gly-betaamibe 3631: bhs-ithiadiaz-nmgly-beta34dcpth 3632: bim-24thiaz-gly-betameph 3633: phhs-me24oxaz-gly-psdap 0 3634: bim-me24thiaz-gly-psdap 3635: bhs-oxadiaz-gly-betaheph 3636: thpy-24thioph-gly-betadcph 3637: gua-25thioph-gly-betaoxope 3638: bhs-42pym-gly-betameph 5 3639: bhs-24thiaz-gly-betafu2 3640: tolhs-25oxaz-gly-betaheph 3641: bhs-25oxaz-nmgly-betahmph 3642: impy-25oxaz-gly-betapym 3643: gua-25thiaz-gly-betamethi D 3644: phhs-oxadiaz-bala-betacthioph 3645: bhs-24thioph-gly-betaibph 3646: phhs-25methiaz-bala-betahmofu 3647: bhs-25oxaz-gly-betacthioph 3648: bhs-oxadiaz-bala-betaipr 5 3649: phhs-24thioph-gly-betaamibe 3650: phhs-nme35pyr-gly-betaamibe 3651: phhs-25methiaz-gly-betaphethio 3652: phhs-25thiaz-gly-betapbiph 3653: ibhs-25oxaz-gly-betapy 3654: tolhs-nme35pyr-gly-aspibua 3655: ibhs-24thiaz-gly-psdapch 3656: 2py-35fur-ala-psdap 3657: tolhs-24thiaz-bala-betaomebendi 3658: ibhs-25methiaz-bala-betadhbfu 3659: ibhs-25methiaz-bala-betaoxaz 3660: bim-25methiaz-gly-asppha 3661: phhs-ithiadiaz-bala-betadmoph - 125 3662: bhs-35fur-ala-betadcph 3663: phhs-25thiaz-bala-betatos 3664: bim-42nmeim-gly-betafu3 3665: bhs-24thioph-gly-beta35dbph 5 3666: ibhs-nme35pyr-bala-betadhbfu 3667: cima-24thiaz-bala-psdap 3668: tolhs-25methiaz-bala-betaol 3669: gua-26py-gly-betaipr 3670: tolhs-ithiadiaz-bala-betaipr 0 3671: ibhs-nme35pyr-gly-csdap 3672: tolhs-24thiaz-gly-betafph 3673: phhs-25methiaz-bala-betaphethio 3674: phhs-ithiadiaz-bala-betafphe 3675: tolhs-24thioph-bala-beta23meoph 5 3676: phhs-25thiaz-bala-aspbzla 3677: tolhs-oxadiaz-gjy-betacbph 3678: bhs-24thiaz-ala-betabnaphth 3679: phhs-25methiaz-bala-betapbiph 3680: 2py-24im-ala-psdap 3 3681: tolhs-24thiaz-bala-betathiobe 3682: pbhs-oxadiaz-gly-betaphethio 3683: tolhs-25oxaz-gly-betahbcph 3684: tolhs-oxadiaz-bala-betacbph 3685: tolhs-25oxaz-gly-beta34meoph 5 3686: bhs-25oxaz-gly-betathiome 3687: dhim-42nmeim-gly-zdap 3688: ibhs-ithiadiaz-gly-betabthioph 3689: ibhs-oxadiaz-gly-betaet 3690: bhs-25methiaz-nmgly-beta34dcph 3691: ibhs-25oxaz-gly-beta23meoph 3692: phhs-25methiaz-gly-betacph 3693: ibhs-nme35pyr-gly-betathio3 3694: bim-me24thiaz-gly-betadcph 3695: phhs-24thioph-gly-csdap 3696: ibhs-nme35pyr-bala-asppha 3697: 2py-me24thioph-ala-psdap 3698: tolhs-25oxaz-gly-zdapee - 126 3699: dhm-26py-gly-psdap 3700: 2py-25thioph-bala-zdap 3701: tolhs-25oxaz-bala-psdapch 3702: phhs-24thioph-gly-zdapch 5 3703: bim-thiadiaz-bala-betadcph 3704: bim-24oxaz-bala-betadcph 3705: tolhs-25oxaz-gly-psdap 3706: bim-52thiaz-gly-zdap 3707: ibhs-oxadiaz-bala-betadito 0 3708: bhs-me24thiaz-bala-zdap 3709: 2py-ithiadiaz-bala-asppha 3710: gua-42pym-gly-betafu2 3711: phhs-25methiaz-bala-betaanaphth 3712: bhs-26py-ala-zdap 5 3713: ibhs-24thiaz-gly-betaoxope 3714: phhs-24thioph-bala-betadcphee 3715: dhim-52thiaz-ala-betainyl 3716: phhs-ithiadiaz-bala-betaanaphth 3717: bhs-24thioph-gly-betafph 0 3718: gua-24thiaz-gly-betahb 3719: bhs-oxadiaz-gly-betaipro 3720: phhs-25methiaz-gly-betatrif 3721: bim-me24thioph-gly-zdap 3722: ibhs-oxadiaz-bala-betaoxaz 5 3723: gua-24thiaz-gly-betacbph 3724: ibhs-ithiadiaz-gly-betahni 3725: bim-ithiadiaz-bala-aspibua 3726: 2py-42oxaz-gly-betadcph 3727: tolhs-ithiadiaz-gly-betaet 3 3728: ibhs-25methiaz-bala-betahdcph 3729: 2py-42nmeim-gly-betacph 3730: tolhs-oxadiaz-bala-betaanaphth 3731: phhs-ithiadiaz-gly-betaanaphth 3732: phhs-ithiadiaz-gly-betafluo 5 3733: tolhs-ithiadiaz-bala-betaftrif 3734: phhs-oxadiaz-gly-betaet 3735: phhs-24thiaz-bala-csdap - 127 3736: ibhs-25oxaz-bala-psdap 3737: 2pmhs-25oxaz-gly-betaol 3738: tolhs-oxadiaz-gly-betadcph 3739: phhs-24thioph-bala-betamesu 5 3740: bhs-25thiaz-gly-betadito 3741: 2py-42pym-ala-betainyl 3742: tolhs-me25oxaz-gly-zdap 3743: 2pmhs-25oxaz-gly-beta3quin 3744: phhs-24thiaz-bala-betahmo 0 3745: tolhs-24thiaz-bala-csdap 3746: bhs-26py-gly-betapy 3747: bim-53pyrazo-leu-betapy 3748: 2py-25methiaz-gly-zdap 3749: ibhs-nme35pyr-gly-betadtrif 5 3750: dhim-42pym-ala-betadcph 3751: ibhs-nme35pyr-bala-zdaptb 3752: bim-25thiaz-gly-betadbph 3753: tolhs-25oxaz-bala-betahmph 3754: tolhs-25methiaz-bala-betahph D 3755: ibhs-ithiadiaz-gly-betapyr 3756: bhs-ithiadiaz-ala-betaipro 3757: ibhs-25methiaz-bala-psdapch 3758: phhs-nme35pyr-bala-zdapee 3759: bim-me25thiaz-bala-beta34meoph 5 3760: tolhs-oxadiaz-bala-betahdcph 3761: phhs-oxadiaz-gly-betampy 3762: ibhs-oxadiaz-gly-betathiome 3763: impy-2thioph-gly-betapy 3764: bhs-25oxaz-gly-betainyl 3765: ibhs-25thiaz-bala-betafph 3766: tolhs-ithiadiaz-gly-betafphe 3767: hts-42pym-gly-betapy 3768: ibhs-24thiaz-gly-betahmph 3769: phhs-nme35pyr-bala-betapyee 3770: tolhs-nme35pyr-gly-beta34meoph 3771: bim-me25thioph-bala-betaph 3772: tolhs-24thiaz-bala-betadmph -128 3773: bhs-ithiadiaz-gly-betaamibe 3774: bhs-25thioph-leu-psdap 3775: bhs-me25thiaz-leu-betaph 3776: bhs-25methiaz-bala-csdap 5 3777: tolhs-25thiaz-gly-beta4bph 3778: bhs-24thioph-nmgly-betainyl 3779: phhs-oxadiaz-gly-betabenf u 3780: phhs-nme35pyr-gly-psdaptb 3781: gua-24thiaz-gly-betatos 0 3782: tolhs-oxadiaz-gly-betabdimo 3783: bhs-25thiaz-gly-betafluo 3784: bhs-triaz-ala-psdap 3785: bhs-35pyrazo-gly-betapy 3786: 2pmhs-24thiaz-bala-betapyr 5 3787: tolhs-25methiaz-bala-betaphethioa 3788: bhs-24thiaz-bala-betahdbph 3789: ibhs-25thiaz-gly-betadcphee 3790: phhs-24thioph-bala-betadito 3791: phhs-oxadiaz-gly-betabdimo D 3792: 2py-24thiazme-gly-betapy 3793: ibhs-nme35pyr-gly-beta34meoph 3794: phhs-ithiadiaz-gly-betahbcph 3795: ibhs-oxadiaz-gly-betaibph 3796: 2py-24thioph-bala-psdap 5 3797: 2pmhs-25oxaz-bala-suabu 3798: bhs-24thioph-nmgly-betabpy 3799: ibhs-oxadiaz-bala-asppha 3800: gua-25thiaz-gly-betaomebendi 3801: 3pmhs-42pym-gly-betapy 3802: tolhs-25thiaz-gly-suabu 3803: ibhs-24thioph-bala-betafu2 3804: tolhs-oxadiaz-bala-psdapch 3805: ibhs-oxadiaz-bala-betadcphtb 3806: phhs-ithiadiaz-bala-betaftrif 3807: ibhs-oxadiaz-gly-betaoxope 3808: 2py-oxadiaz-bala-psdap 3809: tolhs-me25oxaz-gly-psdap - 129 3810: bhs-25methiaz-nmgly-betal3bendi 3811: tolhs-24thiaz-bala-betabpy 3812: hs-42pym-gly-betapy 3813: tolhs-25oxaz-bala-betapbiph 5 3814: ibhs-oxadiaz-bala-beta34meoph 3815: bhs-ithiadiaz-ala-betameph 3816: phhs-me24oxaz-leu-beta34meoph 3817: bhs-25thiaz-nmgly-betafphe 3818: tolhs-ithiadiaz-gly-betafluo 0 3819: tolhs-25thiaz-bala-betamethi 3820: bhs-24thioph-nmgly-betathio3 3821: bhs-24thiaz-hphe-betapy 3822: tolhs-25methiaz-bala-aspbzla 3823: bim-me25thiaz-ala-betadcph 5 3824: bhs-25thiaz-bala-asppha 3825: bhs-nme35pyr-gly-betamesu 3826: ibhs-ithiadiaz-gly-betapyee 3827: phhs-25oxaz-bala-betabnaphth 3828: ibhs-24thioph-gly-betadmoph 0 3829: phhs-ithiadiaz-gly-betabnaphth 3830: tolhs-nme35pyr-gly-beta3quin 3831: bhs-me25thioph-bala-betapy 3832: tolhs-nme35pyr-bala-betapym 3833: bhs-nme35pyr-ala-beta3quin 5 3834: ibhs-25oxaz-gly-betamethioph 3835: tolhs-25thiaz-gly-betaoxaz 3836: phhs-ithiadiaz-bala-betadcphee 3837: tolhs-24thiaz-bala-betaphethioa 3838: 2py-25oxaz-gly-betadcph 3839: tolhs-oxadiaz-bala-betampy 3840: 2py-42oxaz-leu-betapy 3841: ibhs-24thiaz-gly-zdaptb 3842: phhs-ithiadiaz-bala-psdaptb 3843: phhs-nme35pyr-gly-betafluo 3844: bhs-nme35pyr-gly-zdapee 3845: ibhs-24thioph-bala-betaoxaz 3846: ibhs-24thiaz-bala-betaoxaz -130 3847: thazep-25thiaz-gly-beta13bendi 3848: bhs-24thioph-ala-betabnaphth 3849: bhs-ithiadiaz-nmgly-betamesu 3850: phhs-oxadiaz-gly-betacph 5 3851: ibhs-25methiaz-bala-betapyr 3852: 2py-25methiaz-gly-betaol 3853: tolhs-25methiaz-gly-betahbcph 3854: ibhs-25thiaz-bala-betadmph 3855: phhs-25thiaz-gly-beta35dbph 0 3856: ibhs-25thiaz-gly-csdap 3857: phhs-25thiaz-gly-betamethioph 3858: 2py-24thiaz-gly-betathio3 3859: ibhs-ithiadiaz-bala-betahni 3860: gua-25thioph-gly-betathio3 5 3861: bhs-oxadiaz-gly-beta34dcph 3862: dhim-25thiophme-ala-betameph 3863: ibhs-nme35pyr-bala-betahdcph 3864: tolhs-nme35pyr-bala-betathio3 3865: bhs-24thioph-gly-betacthioph 0 3866: phhs-25thiaz-bala-betaol 3867: ibhs-24thiaz-gly-ibsdap 3868: bhs-me24im-gly-betameph 3869: tolhs-24thiaz-gly-betabnaphth 3870: tolhs-me25thiaz-bala-zdap 5 3871: 2py-35fur-bala-zdap 3872: tolhs-oxadiaz-bala-betabthioph 3873: bhs-ithiadiaz-gly-betahph 3874: bgua-25methiaz-gly-betameph 3875: phhs-ithiadiaz-bala-betabediox 3876: phhs-25methiaz-bala-betadcph 3877: ibhs-nme35pyr-gly-betapbiph 3878: tolhs-25methiaz-gly-betabenfu 3879: bim-25thiaz-bala-psdap 3880: bhs-25methiaz-gly-betaet 3881: phhs-me25thioph-bala-psdap 3882: tolhs-25thiaz-gly-betaoxope 3883: tolhs-ithiadiaz-gly-betafu2 - 131 3884: ibhs-oxadiaz-bala-betabpy 3885: bim-25methiaz-gly-aspaba 3886: ibhs-nme35pyr-bala-betaamibe 3887: bhs-25methiaz-bala-betainyl 5 3888: bhs-ithiadiaz-gly-psdapee 3889: bgua-25oxaz-bala-betapy 3890: phhs-25methiaz-gly-betamesu 3891: phhs-25methiaz-bala-betaftrif 3892: ibhs-25thiaz-bala-betaanaphth 0 3893: ibhs-oxadiaz-bala-beta3quin 3894: phhs-25methiaz-bala-zdapch 3895: phhs-nme35pyr-bala-ibsdap 3896: 2pmhs-25methiaz-bala-betathioph 3897: bhs-me24thiaz-leu-betapy 5 3898: phhs-25thiaz-bala-betathiome 3899: tolhs-25thiaz-gly-betapbiph 3900: gua-25thioph-gly-betahmo 3901: bim-25thioph-bala-betapy 3902: tolhs-oxadiaz-bala-beta35dbph D 3903: tolhs-ithiadiaz-gly-aspbzla 3904: tolhs-nme35pyr-bala-betacthioph 3905: bhs-triaz-gly-psdap 3906: ibhs-oxadiaz-bala-betadhbfu 3907: phhs-me25oxaz-leu-zdap 5 3908: tolhs-oxadiaz-gly-betamethioph 3909: bhs-25oxaz-bala-betadbph 3910: bhs-oxadiaz-bala-betameph 3911: phhs-24thiaz-gly-aspaba 3912: bim-25thiaz-bala-betaimid 3913: 2py-24thioph-leu-betadcph 3914: ibhs-25oxaz-gly-betaanaphth 3915: ibhs-nme35pyr-gly-betapyr 3916: tolhs-24thioph-gly-beta35dbph 3917: 2pmhs-25methiaz-bala-betapyr 3918: tolhs-25thiaz-gly-betadmph 3919: 2py-25methiaz-leu-betapy 3920: bhs-oxadiaz-bala-asppha - 132 3921: bhs-25oxaz-gly-betahb 3922: tolhs-24thioph-bala-betameph 3923: phhs-me25oxaz-leu-beta34meoph 3924: 2py-42nmeim-bala-betapy 5 3925: phhs-me25thiaz-ala-betapy 3926: phhs-25methiaz-bala-betampy 3927: ibhs-25oxaz-bala-suabu 3928: bhs-oxadiaz-gly-betabmph 3929: bhs-25oxaz-bala-betambiph 0 3930: tolhs-nme35pyr-gly-aspbzla 3931: ibhs-nme35pyr-gly-betapych 3932: ibhs-24thiaz-gly-betaph 3933: bhs-24thiaz-bala-betacthioph 3934: bhs-me25oxaz-leu-beta34meoph 5 3935: bhs-25oxaz-bala-betahbcph 3936: tolhs-25oxaz-bala-betafbph 3937: tolhs-25methiaz-bala-betabmph 3938: bhs-nme35pyr-nmgly-betadhbfu 3939: phhs-25methiaz-bala-betahni ) 3940: bhs-24thioph-bala-beta34meoph 3941: 2py-24thioph-gly-betadito 3942: bhs-25oxaz-gly-betahph 3943: bhs-25methiaz-gly-psdaptb 3944: ibhs-nme35pyr-gly-betapym 5 3945: ibhs-ithiadiaz-gly-betadmph 3946: bim-24im-leu-zdap 3947: impy-25thiaz-gly-beta34meoph 3948: ur-42pym-ala-psdap 3949: bhs-ithiadiaz-bala-betafbph 3950: bhs-24thiaz-gly-betatos 3951: ibhs-24thioph-gly-zdapee 3952: tolhs-25methiaz-bala-betadcphtb 3953: ibhs-ithiadiaz-bala-betahmo 3954: ibhs-nme35pyr-bala-betahb 3955: phhs-25oxaz-gly-betaet 3956: ibhs-24thiaz-gly-betathio3 3957: bhs-25methiaz-gly-betahmph -133 3958: bhs-42oxaz-ala-psdap 3959: gua-25thiaz-gly-betapy 3960: ibhs-nme35pyr-bala-betahbcph 3961: phhs-nme35pyr-bala-betathiome 5 3962: bim-25methiaz-bala-psdap 3963: bhs-24thiaz-ala-betadmph 3964: phhs-25methiaz-gly-betathiome 3965: phhs-me25thioph-bala-betadcph 3966: bhs-ithiadiaz-bala-betathiome 0 3967: bhs-nme35pyr-bala-betathioph 3968: bim-24thioph-bala-betaimid 3969: phhs-24thioph-gly-betaftrif 3970: bhs-25thiaz-gly-betadcph 3971: phhs-me25thioph-gly-betaph 5 3972: bim-25methiaz-ala-betapy 3973: bhs-24thioph-ala-betathio3 3974: ibhs-24thiaz-bala-aspbzla 3975: phhs-oxadiaz-bala-betahmph 3976: bhs-ithiadiaz-ala-betaanaphth D 3977: bhs-25oxaz-gly-aspaba 3978: bhs-ithiadiaz-gly-betaol 3979: 2py-thiadiaz-leu-betadcph 3980: phhs-me25oxaz-bala-betapy 3981: ibhs-25oxaz-gly-beta34dcph 5 3982: ibhs-oxadiaz-gly-betabmph 3983: bhs-oxadiaz-bala-beta4bph 3984: tolhs-24thiaz-bala-betafu3 3985: bhs-25oxaz-bala-betafu2 3986: tolhs-me25thiaz-ala-psdap 3987: tolhs-25oxaz-bala-betamesu 3988: 2py-26py-gly-betahdcph 3989: bhs-25methiaz-met-betadcph 3990: bhs-me25oxaz-bala-beta34meoph 3991: bim-me24thioph-gly-betaph 3992: bhs-25oxaz-gly-betaibph 3993: phhs-oxadiaz-gly-betahdbph 3994: tolhs-me25oxaz-ala-betadcph -134 3995: 2py-25fur-gly-zdap 3996: bim-thiadiaz-leu-betapy 3997: tolhs-24thiaz-bala-betathioph 3998: 2py-24thioph-gly-betathio3 5 3999: bhs-24thiaz-gly-betahmo 4000: phhs-nme35pyr-gly-betabenfu 4001: ibhs-25thiaz-bala-betapych 4002: bhs-24oxaz-ala-zdap 4003: impy-24thiaz-bala-betamethi 0 4004: ibhs-oxadiaz-gly-betaphethio 4005: tolhs-25thiaz-bala-betaet 4006: phhs-25methiaz-bala-betahmph 4007: phhs-oxadiaz-bala-betadito 4008: bim-25fur-ala-betadcph 5 4009: tolhs-oxadiaz-bala-beta34meoph 4010: bhs-24thioph-ala-betamesu 4011: phhs-25thiaz-gly-betadmoph 4012: bhs-nme35pyr-ala-betaipro 4013: tolhs-25thiaz-gly-betabpy D 4014: ibhs-nme35pyr-gly-betaipr 4015: bhs-25methiaz-gly-betabmph 4016: tolhs-25oxaz-bala-betapych 4017: tolhs-oxadiaz-gly-csdap 4018: tolhs-nme35pyr-bala-beta35dbph 5 4019: 2py-me25thioph-leu-beta34meoph 4020: phhs-oxadiaz-bala-betahni 4021: ibhs-24thioph-bala-betadmph 4022: bhs-25methiaz-gly-betadito 4023: bhs-42nmeim-ala-betadcph 4024: ibhs-25oxaz-bala-betaphethioa 4025: bim-me24thiaz-bala-zdap 4026: bhs-42py-gly-betameph 4027: tolhs-24thioph-gly-betahmph 4028: bim-me24thioph-ala-zdap 4029: bim-me25thiaz-gly-beta34meoph 4030: bhs-25thiaz-bala-betabthioph 4031: bim-25thiaz-gly-aspaba -135 4032: gua-24thiaz-gly-betafbph 4033: thpym-42pym-gly-betahcbph 4034: bhs-nme35pyr-bala-betaamibe 4035: bhs-25oxaz-gly-betapbiph 5 4036: phhs-25thiaz-gly-betahc 4037: 2py-nme35pyr-bala-aspibua 4038: bim-24oxaz-gly-betadcph 4039: phhs-24thioph-gly-betahbcph 4040: 2py-me25thioph-leu-betapy 0 4041: bhs-me25thioph-ala-psdap 4042: bhs-me25oxaz-leu-betapy 4043: tolhs-ithiadiaz-bala-betahmofu 4044: 2py-25thiaz-bala-betabnaphth 4045: bim-24thiaz-gly-betadmph 5 4046: ibhs-24thiaz-gly-betaol 4047: tolhs-25thiaz-gly-betafbph 4048: bhs-42nmeim-bala-betapy 4049: phhs-25methiaz-gly-betahb 4050: phhs-25thiaz-bala-betacbph 0 4051: tolhs-nme35pyr-gly-zdapee 4052: phhs-ithiadiaz-bala-zdaptb 4053: thazep-25thiaz-bala-zdap 4054: 2py-24chin-gly-betapy 4055: ibhs-25methiaz-gly-betapytb 5 4056: bhs-25thiaz-bala-betadcphtb 4057: phhs-25methiaz-bala-betal 3bendi 4058: tolhs-24thiaz-gly-betapbiph 4059: bhs-ithiadiaz-gly-betaipr 4060: 2py-35thioph-gly-zdap 0 4061: phhs-me25thiaz-gly-zdap 4062: ibhs-24thioph-bala-betadcph 4063: tolhs-25oxaz-gly-betambiph 4064: bhs-nme35pyr-gly-betahmph 4065: bhs-25methiaz-ala-psdap 5 4066: tolhs-25thiaz-bala-betafph 4067: tolhs-ithiadiaz-gly-betabph 4068: tolhs-nme35pyr-bala-aspaba - 136 4069: 2py-42oxaz-ala-zdap 4070: ibhs-nme35pyr-bala-betadcphch 4071: 2py-24thiaz-ala-betameph 4072: 2py-24thiaz-gly-betaol 5 4073: ibhs-25methiaz-bala-betapych 4074: 2pmhs-24thiaz-gly-betadtrif 4075: dhim-26pyrazi-gly-betameph 4076: tolhs-24thiaz-gly-betadcph 4077: ibhs-nme35pyr-bala-betapym 0 4078: ibhs-25methiaz-bala-betahb 4079: bhs-24thioph-bala-betadcph 4080: ibhs-oxadiaz-gly-betapyee 4081: bhs-25thiaz-gly-aspibua 4082: bim-me25thiaz-leu-betadcph 5 4083: phhs-25methiaz-bala-betatos 4084: phhs-me25thiaz-ala-psdap 4085: bhs-25methiaz-ala-ibsdap 4086: bim-52thiaz-ala-betadcph 4087: phhs-24thiaz-bala-betambiph D 4088: phhs-ithiadiaz-gly-beta3quin 4089: bhs-24thioph-gly-betapbiph 4090: 2py-25oxaz-bala-betaftrif 4091: bhs-oxadiaz-ala-betameph 4092: tolhs-oxadiaz-bala-betaoxaz 5 4093: ibhs-oxadiaz-bala-betaibph 4094: bhs-24thiaz-gly-betaph 4095: ibhs-nme35pyr-gly-betafbph 4096: tolhs-nme35pyr-gly-betaanaphth 4097: phhs-24thiaz-gly-betamesu 4098: bhs-25oxaz-ala-betadcph 4099: tolhs-ithiadiaz-bala-betaimid 4100: impy-25oxaz-gly-betabph 4101: dhim-42pym-gly-betadtrif 4102: 2py-me25thioph-bala-betapy 4103: ibhs-24thioph-gly-betadtrif 4104: 2py-me24thioph-bala-beta34meoph 4105: bhs-25thiaz-nmgly-ibsdap -137 4106: phhs-nme35pyr-baJa-betahmo 4107: phhs-25oxaz-gly-betaheph 4108: gua-42pym-gly-betainyl 4109: gua-42pym-gly-betaomebendi 5 4110: bhs-25thiaz-bala-betahbcph 4111: tolhs-25oxaz-bala-betabthioph 4112: bhs-nme35pyr-nmgly-betahmph 4113: ibhs-25oxaz-gly-betadmoph 4114: tolhs-nme35pyr-bala-betabmph 0 4115: tolhs-nme35pyr-bala-betapbiph 4116: bhs-25oxaz-bala-betahdcph 4117: impy-24thioph-bala-betamethi 4118: bim-me24oxaz-gly-beta34meoph 4119: phhs-me25oxaz-ala-betapy 5 4120: bim-me24thioph-gly-psdap 4121: bhs-24thioph-gly-betahph 4122: phhs-24thioph-gly-betaol 4123: ibhs-25thiaz-bala-zdaptb 4124: tolhs-nme35pyr-gly-betaamibe 0 4125: bhs-24thiaz-bala-betahb 4126: bhs-24thiaz-gly-zdapch 4127: gua-42pym-gly-betapyr 4128: phhs-oxadiaz-gly-zdapee 4129: bim-25thiaz-ala-psdap 5 4130: bhs-ithiadiaz-gly-betapy 4131: bhs-25methiaz-gly-betacph 4132: ibhs-25oxaz-gly-betaet 4133: 2py-42py-gly-betapy 4134: 2py-25oxaz-gly-betapy 3 4135: bhs-oxadiaz-gly-betafph 4136: ibhs-24thioph-gly-beta3quin 4137: tolhs-25oxaz-bala-betadcphee 4138: 2py-me25oxaz-ala-psdap 4139: bhs-24thioph-nmgly-betadito 5 4140: bhs-nme35pyr-gly-betahdcph 4141: bhs-oxadiaz-bala-betamethi 4142: bhs-nme35pyr-gly-betadcphee - 138 4143: bhs-25methiaz-bala-betaibph 4144: bhs-24thioph-bala-beta23meoph 4145: ibhs-oxadiaz-bala-betatos 4146: tolhs-ithiadiaz-bala-betadtrif 5 4147: bhs-oxadiaz-gly-betapych 4148: tolhs-ithiadiaz-bala-betaamibe 4149: bhs-24thiaz-bala-betadbph 4150: bhs-24thioph-bala-betaphethioa 4151: phhs-25oxaz-bala-betadcphch 0 4152: tolhs-24thiaz-gly-betafluo 4153: phhs-25methiaz-gly-betaimid 4154: tolhs-oxadiaz-gly-betadtrif 4155: bhs-nme35pyr-ala-betadmph 4156: bim-25thiaz-bala-betampy 5 4157: phhs-25methiaz-bala-betathioph 4158: phhs-nme35pyr-gly-zdapch 4159: bhs-25methiaz-gly-betatos 4160: tolhs-25oxaz-bala-betahc 4161: 2py-me24thiaz-ala-beta34meoph 0 4162: tolhs-me24thioph-gly-beta34meoph 4163: bim-oxadiaz-gly-betadcph 4164: ibhs-25thiaz-bala-betapbiph 4165: bhs-25thiaz-bala-betatos 4166: 2py-25methiaz-bala-betapy 5 4167: tolhs-25methiaz-bala-zdapch 4168: gua-42pym-gly-betafluo 4169: bhs-nme35pyr-bala-betaphethioa 4170: tolhs-24thioph-bala-psdapee 4171: phhs-25oxaz-gly-ibsdap ) 4172: ibhs-25thiaz-gly-betabnaphth 4173: 2py-25thiaz-gly-beta35dbph 4174: ibhs-oxadiaz-gly-betaimid 4175: bhs-me25thioph-ala-betapy 4176: phhs-24thioph-gly-betathioph 5 4177: ibhs-24thiaz-gly-betaomebendi 4178: bim-25thiaz-ala-zdap 4179: ibhs-25methiaz-bala-betahmph -139 4180: ibhs-24thioph-gly-betahbcph 4181: bim-25oxaz-gly-betahbcph 4182: bhs-ithiadiaz-gly-betadito 4183: bhs-24thioph-nmgly-betaipro 5 4184: bim-35thioph-ala-zdap 4185: ibhs-25oxaz-gly-betadcphch 4186: phhs-24thiaz-bala-zdapee 4187: bhs-me24thiaz-bala-betaph 4188: bim-nme35pyr-ala-zdap 0 4189: tolhs-25thiaz-gly-betaomebendi 4190: bhs-24thioph-gly-psdapee 4191: tolhs-nme35pyr-bala-zdap 4192: tolhs-nme35pyr-gly-aspaba 4193: ibhs-oxadiaz-bala-betatbuph 5 4194: tolhs-25oxaz-gly-betameph 4195: 2py-thiadiaz-bala-betadcph 4196: bim-24im-gly-betapy 4197: phhs-24thioph-gly-betadtrif 4198: bhs-nme35pyr-bala-betabph D 4199: 2py-24thioph-bala-aspibua 4200: bhs-25methiaz-bala-betafbph 4201: bhs-24thiaz-bala-betaibph 4202: impy-25thiaz-nmgly-psdap 4203: phhs-oxadiaz-gly-betatos 5 4204: phhs-24thioph-gly-betal 3bendi 4205: bim-triaz-leu-betadcph 4206: phhs-25methiaz-bala-csdap 4207: phhs-nme35pyr-gly-betainyl 4208: ibhs-nme35pyr-bala-beta4bph ) 4209: phhs-ithiadiaz-bala-betahni 4210: 2py-24thiaz-ala-psdap 4211: tolhs-25thiaz-bala-beta4bph 4212: bhs-25thiaz-gly-beta34dcph 4213: bhs-25thiaz-bala-betaf u3 5 4214: phhs-24thioph-gly-beta35dbph 4215: phhs-24thiaz-gly-betadmoph 4216: bhs-oxadiaz-ala-betal 3bendi -140 4217: 2pmhs-25oxaz-bala-betafluo 4218: phhs-25oxaz-gly-zdaptb 4219: phhs-24thiaz-bala-betamesu 4220: ibhs-24thioph-gly-betaph 5 4221: tolhs-nme35pyr-gly-betafphe 4222: bhs-25methiaz-gly-betabthioph 4223: bhs-25thiaz-bala-psdap 4224: tolhs-25methiaz-gly-betaibph 4225: bhs-me25oxaz-leu-betadcph 0 4226: 2pmhs-25oxaz-bala-beta34dcph 4227: 2pmhs-24thiaz-bala-betabmph 4228: bim-24im-ala-betapy 4229: phhs-25thiaz-gly-betathio3 4230: ibhs-nme35pyr-gly-betahbcph 5 4231: tolhs-25oxaz-bala-betaol 4232: phhs-nme35pyr-bala-zdapch 4233: phhs-24thiaz-gly-betacph 4234: ibhs-24thioph-gly-betamethi 4235: 2pmhs-25thiaz-gly-betabpy 0 4236: phhs-24thioph-bala-zdapee 4237: phhs-oxadiaz-bala-betapyee 4238: ibhs-24thioph-gly-csdap 4239: tolhs-oxadiaz-bala-betapyr 4240: bim-25thiaz-bala-aspibua 5 4241: bhs-oxadiaz-gly-ibsdap 4242: bim-53pyrazo-leu-betadcph 4243: bhs-ithiadiaz-bala-betafu3 4244: tolhs-ithiadiaz-bala-betambiph 4245: ibhs-25methiaz-bala-betabdimo 4246: impy-25thiaz-gly-betathiobe 4247: bhs-oxadiaz-gly-betaanaphth 4248: tolhs-25thiaz-bala-betahdbph 4249: bhs-oxadiaz-bala-betathio3 4250: bhs-25fur-leu-betadcph i 4251: 2py-me25thioph-ala-betadcph 4252: phhs-24thioph-bala-betamethi 4253: 2pmhs-25oxaz-gly-psdap - 141 4254: bhs-oxadiaz-gly-betahmo 4255: phhs-nme35pyr-bala-aspbzla 4256: nmhs-25thiaz-gly-betadcph 4257: bhs-24thiaz-ala-betadmoph 5 4258: impy-25thiaz-bala-psdap 4259: bim-24oxaz-gly-betapy 4260: bhs-25oxaz-gly-suabu 4261: bim-25thioph-gly-betapy 4262: bim-25methiaz-bala-aspibua D 4263: bhs-oxadiaz-gly-betahdcph 4264: ibhs-24thiaz-bala-betacthioph 4265: tolhs-24thiaz-gly-betaamibe 4266: tolhs-24thioph-bala-beta3quin 4267: ibhs-25thiaz-bala-betamesu 5 4268: phhs-oxadiaz-bala-zdapee 4269: ibhs-24thiaz-bala-betahmofu 4270: bhs-25methiaz-bala-betaet 4271: ibhs-25thiaz-gly-betaheph 4272: ibhs-24thiaz-bala-beta34meoph 4273: ibhs-nme35pyr-bala-betathioph 4274: bhs-25methiaz-bala-betafluo 4275: bim-25oxaz-ala-betapy 4276: phhs-24thioph-bala-betapbiph 4277: tolhs-24thiaz-gly-betadito 4278: bim-42oxaz-ala-psdap 4279: bhs-24thiophme-gly-zdap 4280: tolhs-24thiaz-bala-betadcphtb 4281: bhs-25thiaz-bala-betabpy 4282: phhs-me25oxaz-leu-betaph 4283: phhs-nme35pyr-gly-beta3quin 4284: bhs-oxadiaz-bala-betabthioph 4285: bim-nme35pyr-bala-aspibua 4286: bhs-25thiaz-bala-betaphethio 4287: ibhs-25thiaz-bala-betaoxaz 4288: bhs-nme35pyr-gly-zdaptb 4289: ibhs-25oxaz-bala-busu2be 4290: bhs-25methiaz-nmgly-betadmoph - 142 4291: tolhs-oxadiaz-bala-betameph 4292: bhs-24thiaz-gly-betabiph 4293: ibhs-25methiaz-bala-betapym 4294: tolhs-nme35pyr-gly-betathioph 5 4295: tolhs-25methiaz-bala-psdapch 4296: 2py-25thiaz-gly-asppha 4297: tolhs-24thiaz-bala-betahc 4298: 2pmhs-25thioph-gly-betapy 4299: ibhs-24thiaz-bala-betaph 0 4300: impy-25methiaz-bala-betamethi 4301: phhs-oxadiaz-gly-betathiobe 4302: ibhs-25thiaz-gly-betathioph 4303: gua-25thiaz-gly-betacthioph 4304: phhs-24thioph-gly-beta3quin 5 4305: phhs-oxadiaz-bala-betafph 4306: phhs-ithiadiaz-bala-betaoxope 4307: tolhs-25methiaz-bala-betahdcph 4308: bhs-24oxaz-leu-psdap 4309: ibhs-24thiaz-bala-betahdcph D 4310: gua-24thiaz-gly-betahc 4311: phhs-24thiaz-bala-betadbph 4312: 2pmhs-25oxaz-gly-betatbuph 4313: ibhs-24thioph-bala-psdap 4314: bim-24thioph-bala-betapy 5 4315: tolhs-24thiaz-gly-betal 3bendi 4316: pahs-25thiaz-gly-betapy 4317: thazep-24thiaz-bala-zdap 4318: phhs-24thioph-gly-betameph 4319: impy-24thioph-gly-betaipr 4320: 2py-42nmeim-bala-betatrif 4321: phhs-24thiaz-gly-psdapee 4322: phhs-oxadiaz-gly-beta35dbph 4323: thpym-24thiaz-gly-betacbph 4324: phhs-24thiaz-bala-zdap 4325: ibhs-24thioph-bala-betapyee 4326: tolhs-ithiadiaz-gly-betaipro 4327: bhs-26py-gly-zdap - 143 4328: phhs-ithiadiaz-bala-betal3bendi 4329: ibhs-25methiaz-gly-betaheph 4330: bhs-nme35pyr-gly-betacph 4331: bhs-thiadiaz-leu-zdap 5 4332: tolhs-24thiaz-gly-betafu3 4333: 2py-ithiadiaz-leu-psdap 4334: thpym-42pym-gly-beta35dbph 4335: bhs-35fur-leu-zdap 4336: bim-me25thiaz-ala-psdap 0 4337: bim-thiadiaz-bala-betapy 4338: bhs-25thiaz-bala-betadcphee 4339: ibhs-ithiadiaz-bala-betadhbfu 4340: phhs-24thiaz-bala-betafu2 4341: bhs-oxadiaz-bala-aspibua 5 4342: tolhs-25thiaz-gly-betamethioph 4343: bhs-25oxaz-nmgly-betadhbfu 4344: 3pmhs-24thiaz-bala-betapy 4345: 2py-42pym-ala-zdap 4346: tolhs-24thioph-gly-betaoxaz D 4347: phhs-25oxaz-bala-betaimid 4348: bim-25oxaz-bala-aspibua 4349: phhs-nme35pyr-gly-betathiobe 4350: ibhs-24thioph-bala-betahc 4351: bhs-nme35pyr-bala-zdapee 5 4352: 2py-24thiaz-bala-betaoxope 4353: bhs-25thiaz-ala-betamesu 4354: phhs-25methiaz-bala-betah35dc 4355: bhs-25oxaz-gly-betacbph 4356: tolhs-25thiaz-gly-beta3quin 4357: bhs-oxadiaz-gly-betadbph 4358: tolhs-25oxaz-bala-betameph 4359: phhs-24thiaz-gly-beta4bph 4360: 2py-me25thiaz-leu-betadcph 4361: 2py-nme35pyr-gly-betapy i 4362: bhs-25oxaz-bala-betacph 4363: bhs-25methiaz-bala-betal 3bendi 4364: dhim-25thiaz-gly-psdap -144 4365: 2py-42nmeim-bala-betadbph 4366: bhs-ithiadiaz-gly-betapytb 4367: phhs-ithiadiaz-bala-betatos 4368: tolhs-oxadiaz-bala-betafu3 5 4369: 2py-24thiaz-gly-aspbzla 4370: bhs-25oxaz-bala-betaibph 4371: ibhs-ithiadiaz-gly-betahb 4372: ibhs-25thiaz-bala-betadcph 4373: ibhs-24thiaz-gly-beta23meoph 0 4374: tolhs-nme35pyr-bala-betatbuph 4375: bhs-24thioph-bala-betapyr 4376: ibhs-nme35pyr-gly-betahcbph 4377: bhs-53pyrazo-gly-psdap 4378: pahs-24thiaz-bala-betameph 5 4379: ibhs-oxadiaz-gly-betabpy 4380: tolhs-nme35pyr-gly-betatrif 4381: phhs-25thiaz-bala-betabdimo 4382: ibhs-25oxaz-bala-betaheph 4383: tolhs-24thiaz-gly-betaibph D 4384: 2py-triaz-ala-betapy 4385: bhs-25methiaz-gly-betadmph 4386: phhs-25thiaz-bala-betaibph 4387: ibhs-25thiaz-gly-betahcbph 4388: phhs-oxadiaz-bala-beta35dbph 5 4389: bim-nme35pyr-ala-psdap 4390: phhs-25oxaz-bala-betahmofu 4391: bim-25thiaz-bala-betatos 4392: ibhs-25oxaz-bala-psdapee 4393: hts-24thioph-gly-betapy 4394: bhs-25methiaz-bala-beta4bph 4395: bhs-me25thiaz-gly-betapy 4396: bhs-25methiaz-gly-betaibph 4397: bhs-25oxaz-bala-betaanaphth 4398: bhs-25thiaz-gly-betaphethio 5 4399: phhs-24thiaz-bala-beta23meoph 4400: tolhs-24thiaz-gly-csdap 4401: phhs-oxadiaz-gly-betaol - 145 4402: ibhs-nme35pyr-gly-aspibua 4403: pahs-25oxaz-gly-betapy 4404: bhs-oxadiaz-bala-betal 3bendi 4405: phhs-24thioph-gly-betafbph 5 4406: ibhs-25thiaz-gly-betaimid 4407: bhs-oxadiaz-nmgly-betabnaphth 4408: phhs-25oxaz-gly-betainyl 4409: bim-ithiadiaz-gly-aspbzla 4410: tolhs-24thioph-gly-betacph 0 4411: bhs-nme35pyr-gly-betaphethio 4412: 2py-42oxaz-gly-betapy 4413: ibhs-24thiaz-bala-betamesu 4414: bhs-24thioph-bala-betahb 4415: tolhs-oxadiaz-bala-betahph 5 4416: bhs-nme35pyr-bala-betapytb 4417: tolhs-24thiaz-gly-betahc 4418: bim-35thioph-leu-betadcph 4419: bhs-25methiaz-bala-betahmo 4420: bim-me25thioph-gly-beta34meoph 0 4421: 4pmhs-25thiaz-gly-betapy 4422: phhs-25thiaz-bala-betahmph 4423: phhs-25methiaz-gly-aspbzla 4424: gua-24thiaz-gly-betacthioph 4425: thpym-25thioph-gly-betacbph 5 4426: dhim-25thiaz-gly-betapy 4427: ibhs-25methiaz-bala-zdap 4428: bhs-25methiaz-bala-busu2be 4429: bim-24thioph-gly-betahmph 4430: phhs-nme35pyr-gly-betaipro D 4431: bhs-me24oxaz-ala-beta34meoph 4432: bhs-nme35pyr-ala-betacthioph 4433: bim-42oxaz-ala-betapy 4434: bhs-24thioph-gly-betadmph 4435: phhs-25methiaz-gly-betahbcph 5 4436: tolhs-24thioph-gly-betathiobe 4437: ibhs-25oxaz-bala-betaoxaz 4438: ibhs-nme35pyr-bala-betameph -146 4439: tolhs-ithiadiaz-gly-betapbiph 4440: bim-24thioph-bala-aspbzla 4441: 2py-nme35pyr-leu-betapy 4442: dhthi-24oxaz-gly-betapy 4443: tolhs-24thioph-gly-betadmph 4444: phhs-25thiaz-bala-psdaptb 4445: 2py-me25oxaz-gly-beta34meoph 4446: tolhs-oxadiaz-gly-betapyr 4447: bhs-24thiaz-gly-betamethi 4448: bhs-24thiaz-bala-betaph 4449: bhs-oxadiaz-bala-betahdcph 4450: gua-25thioph-gly-betahcbph 4451: 2py-52thiaz-gly-betainyl 4452: tolhs-oxadiaz-bala-betacthioph 4453: 2py-25methiaz-gly-betadcph 4454: bhs-oxadiaz-gly-betatrif 4455: tolhs-24thioph-gly-betabmh 4456: tolhs-25methiaz-bala-betadcph 4457: bim-triaz-ala-betadcph 4458: bhs-nme35pyr-gly-beta3quin 4459: phhs-24thioph-gly-betahb 4460: phhs-25thiaz-gly-betafbph 4461: impy-42nmeim-bala-betadtrif 4462: phhs-24thiaz-bala-suabu 4463: tolhs-24thioph-bala-betapyr 4464: bhs-25thiaz-ala-betadmoph 4465: bhs-25thiaz-bala-betah35dc 4466: hts-24thiaz-gly-betapy 4467: phhs-ithiadiaz-bala-betahdcph 4468: ibhs-24thiaz-bala-betamethioph 4469: bim-oxadiaz-gly-psdap 4470: bim-oxadiaz-leu-zdap 4471: ibhs-oxadiaz-gly-ibsdap 4472: tolhs-me24thioph-leu-beta34meoph 4473: phhs-ithiadiaz-bala-aspaba 4474: ibhs-oxadiaz-bala-betah35dc 4475: phhs-25methiaz-bala-betapych -147 4476: phhs-24thioph-gly-betabph 4477: impy-25thiaz-gly-betambiph 4478: bhs-25thiaz-gly-betafu2 4479: ibhs-oxadiaz-gly-psdapee 5 4480: bhs-24thioph-bala-betaimid 4481: tolhs-24thioph-gly-psdap 4482: ibhs-oxadiaz-bala-psdapch 4483: phhs-24thiaz-gly-betabthioph 4484: bim-26py-gly-betadcph 0 4485: bhs-24thioph-bala-betahmph 4486: ibhs-25oxaz-gly-betafphe 4487: bhs-25oxaz-gly-betaipr 4488: tolhs-24thiaz-gly-betahdcph 4489: gua-24oxaz-gly-betahmofu 5 4490: tolhs-24thioph-bala-betacph 4491: tolhs-24thioph-gly-beta34meoph 4492: bhs-oxadiaz-bala-beta35dbph 4493: phhs-ithiadiaz-gly-betaet 4494: bim-24thioph-bala-csdap D 4495: bhs-25methiaz-gly-zdaptb 4496: bhs-nme35pyr-bala-betaphethio 4497: ibhs-24thiaz-gly-betathioph 4498: tolhs-24thiaz-bala-betapych 4499: tolhs-oxadiaz-gly-betadcphch 5 4500: bhs-ithiadiaz-leu-betadcph 4501: phhs-nme35pyr-gly-betaimid 4502: tolhs-24thiaz-gly-betahni 4503: 2py-26py-gly-csdap 4504: bhs-triaz-bala-zdap 4505: tolhs-25oxaz-bala-betapyee 4506: phhs-oxadiaz-gly-betabediox 4507: bhs-25thiaz-gly-betapy 4508: tolhs-ithiadiaz-bala-beta23meoph 4509: gua-26py-gly-betambiph 4510: 2pmhs-24thioph-gly-betameph 4511: phhs-oxadiaz-bala-betaipro 4512: tolhs-nme35pyr-gly-betaimid -148 4513: tolhs-nme35pyr-gly-beta34dcph 4514: phhs-25thiaz-bala-betabpy 4515: 2py-24thioph-gly-psdap 4516: ibhs-24thioph-gly-betadcphch 5 4517: phhs-25methiaz-gly-betafphe 4518: tolhs-25methiaz-bala-betambiph 4519: tolhs-24thiaz-bala-betatrif 4520: phhs-oxadiaz-gly-betahc 4521: bim-oxadiaz-bala-zdap 0 4522: phhs-25methiaz-bala-betahb 4523: phhs-25methiaz-gly-zdapee 4524: bim-25thiaz-gly-betadmph 4525: phhs-25oxaz-gly-betatbuph 4526: phhs-25oxaz-gly-zdapee 5 4527: bhs-nme35pyr-ala-betahmph 4528: 2py-me24thiaz-ala-zdap 4529: tolhs-ithiadiaz-bala-betahdbph 4530: ibhs-24thiaz-gly-zdapee 4531: tolhs-25methiaz-bala-betadcphee 4532: phhs-nme35pyr-bala-betaanaphth 4533: bhs-nme35pyr-bala-betaanaphth 4534: tolhs-nme35pyr-gly-betathiome 4535: ibhs-25methiaz-gly-betacthioph 4536: bhs-24thioph-gly-betah35dc 4537: bim-24oxaz-ala-psdap 4538: ibhs-oxadiaz-gly-betadcphee 4539: tolhs-oxadiaz-bala-betaol 4540: ibhs-ithiadiaz-bala-aspbzla 4541: 2py-26py-ala-zdap 4542: tolhs-oxadiaz-gly-betafu3 4543: bhs-me24thioph-leu-zdap 4544: dhpyrr-24oxaz-gly-betameph 4545: bhs-24thiaz-gly-psdap 4546: tolhs-oxadiaz-bala-betambiph 4547: phhs-24thioph-gly-betafphe 4548: tolhs-ithiadiaz-bala-betacbph 4549: phhs-24thiaz-bala-betadcphee -149 4550: ibhs-25oxaz-gly-betampy 4551: phhs-oxadiaz-bala-aspaba 4552: bim-25oxaz-bala-betapyr 4553: phhs-25oxaz-bala-beta35dbph 5 4554: ibhs-25thiaz-bala-ibsdap 4555: ibhs-nme35pyr-gly-betaoxope 4556: tolhs-oxadiaz-gly-betabpy 4557: phhs-nme35pyr-bala-beta3quin 4558: tolhs-nme35pyr-gly-betamesu 0 4559: bhs-24thiaz-bala-betacph 4560: ibhs-nme35pyr-bala-betaheph 4561: 2pmhs-24thioph-bala-beta4bph 4562: bhs-thiadiaz-bala-betapy 4563: phhs-nme35pyr-bala-betadbph 5 4564: 2py-26py-gly-betapy 4565: bim-me24thiop.h-ala-psdap 4566: tolhs-me24thioph-ala-betaph 4567: phhs-24thioph-bala-betacthioph 4568: phhs-ithiadiaz-bala-betapym 3 4569: bhs-24thiaz-bala-betatrif 4570: phhs-25thiaz-bala-betaimid 4571: bhs-24thiaz-bala-betaet 4572: 2pmhs-24thioph-bala-betal 3bendi 4573: 2py-me24thiaz-leu-psdap 5 4574: tolhs-24thioph-bala-betaph 4575: ibhs-25oxaz-gly-betahmo 4576: phhs-nme35pyr-bala-betapytb 4577: tolhs-ithiadiaz-gly-betadmph 4578: tolhs-ithiadiaz-gly-betahmofu 4579: phhs-24thioph-bala-betahcbph 4580: phhs-25methiaz-gly-beta4bph 4581: phhs-nme35pyr-bala-betafluo 4582: tolhs-24thiaz-gly-betah35dc 4583: ibhs-25methiaz-gly-betaet 4584: ibhs-25methiaz-bala-betabmph 4585: tolhs-25oxaz-gly-betahph 4586: bhs-ithiadiaz-nmgly-betameph -150 4587: ibhs-ithiadiaz-bala-ibsdap 4588: 2pmhs-25thiaz-bala-zdap 4589: bhs-25oxaz-gly-beta3quin 4590: ibhs-ithiadiaz-gly-psdap 5 4591: tolhs-ithiadiaz-bala-betathio3 4592: phhs-24thiaz-bala-betahdbph 4593: phhs-25methiaz-bala-betafu2 4594: bhs-nme35pyr-bala-betafphe 4595: ibhs-24thioph-gly-betapym 0 4596: tolhs-25thiaz-gly-csdap 4597: ibhs-nme35pyr-gly-betafphe 4598: gua-24thiaz-gly-betabediox 4599: bim-25thioph-gly-betameph 4600: 2py-25oxaz-gly-zdap 5 4601: ibhs-ithiadiaz-gly-betabediox 4602: bhs-25oxaz-gly-betabediox 4603: ibhs-25methiaz-bala-betah35dc 4604: bhs-24thiazme-ala-betameph 4605: gua-24thiaz-gly-betaimid D 4606: bhs-25thiaz-gly-betaipro 4607: ibhs-25methiaz-bala-betafu2 4608: bhs-24thioph-bala-psdapee 4609: phhs-24thiaz-gly-betah35dc 4610: bhs-52thiaz-ala-psdap 5 4611: ibhs-25oxaz-gly-betapyee 4612: ibhs-25thiaz-gly-psdap 4613: nmhs-25oxaz-bala-zdap 4614: tolhs-24thiaz-gly-betabdimo 4615: bhs-25thiaz-ala-beta23meoph ) 4616: gua-24thiaz-gly-betampy 4617: tolhs-ithiadiaz-gly-betatrif 4618: bhs-42pym-ala-betameph 4619: bhs-25methiaz-ala-betacthioph 4620: phhs-oxadiaz-bala-betadcphtb 5 4621: bhs-24thioph-bala-betafu3 4622: tolhs-25oxaz-bala-betafu2 4623: bhs-25oxaz-bala-betaamibe -151 4624: bim-25methiaz-gly-betadcph 4625: gua-24thiaz-gly-betacph 4626: bhs-24thiaz-nmgly-beta34meoph 4627: tolhs-me25thioph-bala-betaph 5 4628: bhs-nme35pyr-gly-betafluo 4629: ibhs-25thiaz-bala-betahmph 4630: phhs-25oxaz-bala-betaph 4631: tolhs-me24thioph-ala-beta34meoph 4632: bhs-nme35pyr-gly-beta35dbph 0 4633: dimethpym-24thiaz-gly-betadcph 4634: ibhs-25methiaz-bala-betaimid 4635: ibhs-24thioph-bala-betabthioph 4636: tolhs-nme35pyr-bala-betapyee 4637: hyd-25thiaz-gly-betainyl 5 4638: tolhs-25oxaz-bala-betapyr 4639: bhs-ithiadiaz-gly-betahdcph 4640: bhs-oxadiaz-bala-betadmoph 4641: phhs-me25oxaz-ala-betadcph 4642: phhs-25methiaz-bala-betameph 3 4643: bhs-24thiaz-gly-betahc 4644: bhs-me24thioph-leu-betapy 4645: ibhs-25methiaz-bala-betahc 4646: phhs-me24oxaz-ala-betaph 4647: phhs-24thiaz-gly-betahmofu 5 4648: bhs-ithiadiaz-ala-betadmoph 4649: dimethpym-25thioph-gly-betahdcph 4650: bim-25methiaz-bala-betadcph 4651: bhs-24thioph-nmgly-betadmoph 4652: tolhs-25methiaz-bala-betatbuph 4653: phhs-24thiaz-gly-betathiome 4654: phhs-25oxaz-gly-psdaptb 4655: ibhs-ithiadiaz-bala-betapbiph 4656: ibhs-nme35pyr-bala-betaet 4657: tolhs-25thiaz-bala-zdaptb 4658: bhs-25thiaz-gly-beta3quin 4659: bim-52thiaz-ala-betainyl 4660: bhs-24thioph-ala-betadito -152 4661: 2py-42nmeim-ala-psdap 4662: phhs-25thiaz-gly-beta3quin 4663: tolhs-oxadiaz-bala-betal 3bendi 4664: ibhs-25methiaz-gly-betabmph 5 4665: ibhs-25methiaz-bala-beta23meoph 4666: bhs-24thioph-gly-betahb 4667: tolhs-oxadiaz-gly-betafluo 4668: gua-24thiaz-gly-betabph 4669: ibhs-25oxaz-gly-aspaba 0 4670: bhs-25oxaz-ala-zdap 4671: tolhs-25thiaz-bala-betahni 4672: bim-42nmeim-gly-betamesu 4673: dhthi-24thiaz-gly-betapy 4674: phhs-nme35pyr-bala-psdap 5 4675: ibhs-25oxaz-gly-betatos 4676: bhs-nme35pyr-gly-betapyee 4677: 2py-24thiaz-bala-psdap 4678: tolhs-oxadiaz-gly-betah35dc 4679: tolhs-24thioph-bala-betapytb 3 4680: gua-24thiaz-gly-beta34dcph 4681: phhs-24thioph-bala-zdap 4682: bhs-ithiadiaz-bala-betahni 4683: gua-25thiaz-gly-betampy 4684: phhs-nme35pyr-bala-beta34dcph 5 4685: tolhs-nme35pyr-bala-betahph 4686: bhs-24thioph-ala-betameph 4687: phhs-25thiaz-bala-betabediox 4688: ibhs-24thioph-gly-betahmph 4689: tolhs-nme35pyr-bala-betahmph 4690: bhs-25oxaz-gly-betampy 4691: bhs-ithiadiaz-bala-beta4bph 4692: phhs-25methiaz-gly-betadtrif 4693: bhs-me25thiaz-gly-zdap 4694: phhs-25oxaz-gly-busu2be 4695: bhs-nme35pyr-bala-betafu2 4696: ibhs-25methiaz-bala-betathiobe 4697: ibhs-25oxaz-gly-betabdimo -153 4698: bim-ithiadiaz-ala-psdap 4699: tolhs-oxadiaz-gly-betaimid 4700: ibhs-24thioph-gly-betaftrif 4701: 2py-me25thiaz-ala-betadcph 5 4702: ibhs-25methiaz-bala-suabu 4703: bhs-24thiaz-bala-betafu3 4704: ibhs-25thiaz-gly-betal 3bendi 4705: bim-53pyrazo-gly-zdap 4706: bhs-nme35pyr-bala-betapych 0 4707: bhs-25methiaz-bala-betahdcph 4708: phhs-24thiaz-gly-betaphethio 4709: ibhs-25methiaz-gly-betahmofu 4710: bhs-25oxaz-bala-betahmofu 4711: phhs-25methiaz-gly-betafbph 5 4712: ibhs-24thiaz-gly-betamethi 4713: ibhs-25methiaz-gly-psdap 4714: phhs-nme35pyr-bala-betadmph 4715: phhs-oxadiaz-gly-betal 3bendi 4716: tolhs-24thiaz-bala-betadcphee 3 4717: bhs-ithiadiaz-gly-betatos 4718: ibhs-25oxaz-gly-betaphethioa 4719: ibhs-nme35pyr-gly-beta4bph 4720: bhs-oxadiaz-nmgly-betahph 4721: tolhs-ithiadiaz-bala-betahcbph 5 4722: bhs-25thiaz-gly-betabdimo 4723: bhs-24thiaz-ala-ibsdap 4724: phhs-25methiaz-bala-betafph 4725: bhs-ithiadiaz-gly-betambiph 4726: gua-25methiaz-bala-betadcph 4727: bhs-nme35pyr-ala-betathioph 4728: ibhs-25thiaz-gly-betadcphtb 4729: bhs-nme35pyr-bala-betahni 4730: ibhs-24thiaz-bala-betaamibe 4731: bhs-me24thiaz-ala-zdap 4732: phhs-24thiaz-gly-betaph 4733: ibhs-25methiaz-gly-betahb 4734: bhs-24thiaz-gly-betatrif -154 4735: bhs-25oxaz-gly-aspbzla 4736: phhs-nme35pyr-gly-betadmoph 4737: bim-25oxaz-ala-zdap 4738: gua-24thiaz-gly-betaibph 5 4739: ibhs-nme35pyr-gly-betapyee 4740: dhim-25thiaz-gly-zdap 4741: tolhs-25methiaz-bala-beta3quin 4742: tolhs-me24thioph-bala-betadcph 4743: ibhs-oxadiaz-bala-betaomebendi 0 4744: tolhs-25thiaz-gly-betaheph 4745: bhs-53pyrazo-leu-betapy 4746: bim-25fur-bala-psdap 4747: bim-25thiaz-leu-psdap 4748: bim-42nmeim-bala-zdap 5 4749: gua-26py-gly-betabmph 4750: bim-me25thiaz-leu-beta34meoph 4751: bim-oxadiaz-bala-asppha 4752: bhs-24im-gly-betapy 4753: tolhs-25thiaz-bala-betadtrif 0 4754: phhs-25methiaz-bala-betapyr 4755: 2py-24thiaz-gly-betadito 4756: ibhs-24thioph-gly-betadmph 4757: phhs-oxadiaz-bala-psdaptb 4758: bhs-me24thioph-ala-betapy 5 4759: tolhs-me25thiaz-leu-psdap 4760: tolhs-24thiaz-bala-beta35dbph 4761: pahs-24thiaz-gly-betapy 4762: dhim-25thioph-ala-betapy 4763: bhs-24thioph-bala-betahmo 0 4764: bhs-me24oxaz-ala-betaph 4765: ibhs-25oxaz-gly-betatbuph 4766: thpym-26py-gly-betainyl 4767: bhs-25methiaz-bala-beta23meoph 4768: phhs-24thiaz-bala-betabpy 5 4769: 2py-53pyrazo-ala-zdap 4770: tolhs-25methiaz-bala-betabpy 4771: phhs-oxadiaz-bala-betahdcph - 155 4772: bhs-24thioph-gly-betamethioph 4773: phhs-ithiadiaz-gly-betahdbph 4774: phhs-25thiaz-gly-zdaptb 4775: bhs-ithiadiaz-gly-betabthioph 5 4776: bhs-24thioph-bala-beta34dcph 4777: bhs-24thiaz-gly-betahmofu 4778: bhs-25thiaz-bala-betadcphch 4779: tolhs-25methiaz-gly-betatbuph 4780: ibhs-24thiaz-bala-aspaba 0 4781: thpym-25thiaz-gly-beta35dbph 4782: gua-26py-gly-betacph 4783: ibhs-oxadiaz-bala-betadcph 4784: ibhs-24thiaz-gly-betainyl 4785: bim-24py-gly-zdap 5 4786: 2py-52thiaz-ala-zdap 4787: phhs-24thiaz-gly-betal 3bendi 4788: ibhs-ithiadiaz-bala-busu2be 4789: bhs-35thioph-ala-betadcph 4790: phhs-25oxaz-bala-beta34dcph 0 4791: bhs-24thiaz-gly-betabthioph 4792: phhs-24thiaz-bala-betaamibe 4793: bhs-24thioph-gly-betadcph 4794: tolhs-ithiadiaz-gly-betatbuph 4795: ibhs-nme35pyr-bala-betaol 5 4796: tolhs-25methiaz-gly-betacbph 4797: phhs-24thiaz-bala-betadmph 4798: tolhs-24thioph-bala-betaipro 4799: bhs-25thiaz-ala-betaipro 4800: bhs-25thiaz-bala-betaamibe ) 4801: tolhs-24thiaz-bala-betambiph 4802: bhs-triaz-gly-betapy 4803: bhs-25oxaz-gly-betathioph 4804: bhs-25oxaz-bala-betafu3 4805: ibhs-25oxaz-bala-zdapch 5 4806: bhs-35thioph-bala-betadcph 4807: phhs-oxadiaz-bala-betadcphch 4808: phhs-ithiadiaz-bala-asppha -156 4809: bim-me24thiaz-gly-beta34meoph 4810: ibhs-25methiaz-gly-betaftrif 4811: 3pmhs-25methiaz-bala-betapy 4812: ibhs-25thiaz-gly-betadhbfu 5 4813: tolhs-24thioph-gly-betaipr 4814: ibhs-25thiaz-gly-betabmph 4815: bhs-25methiaz-bala-zdaptb 4816: bhs-25thiaz-ala-betaheph 4817: bhs-ithiadiaz-bala-betahmph 0 4818: bim-42pym-gly-betadcph 4819: bhs-25methiaz-gly-psdap 4820: phhs-25oxaz-gly-betacph 4821: bhs-nme35pyr-gly-zdap 4822: bhs-oxadiaz-bala-beta34meoph 5 4823: tolhs-me24thiaz-leu-betapy 4824: ibhs-25oxaz-bala-betahc 4825: bhs-25methiaz-bala-betahmph 4826: ibhs-24thiaz-bala-zdapch 4827: tolhs-25methiaz-gly-betadmph 3 4828: 2py-26py-gly-betadcph 4829: dhim-24thiaz-ala-betadcph 4830: bhs-24thiaz-ala-betacph 4831: phhs-ithiadiaz-bala-aspibua 4832: bhs-25thiaz-ala-betahph 5 4833: phhs-24thioph-bala-betahdcph 4834: bhs-24thiaz-nmgly-betathioph 4835: tolhs-ithiadiaz-gly-asppha 4836: ibhs-24thioph-gly-betaphethioa 4837: phhs-24thiaz-bala-psdap 4838: phhs-25oxaz-bala-betathio3 4839: ibhs-24thioph-gly-betatbuph 4840: ibhs-nme35pyr-gly-betadcphee 4841: phhs-me24thiaz-bala-zdap 4842: ibhs-24thioph-bala-betahdbph 4843: tolhs-25thiaz-bala-betaipr 4844: gua-26py-gly-betabenfu 4845: ibhs-oxadiaz-bala-betadtrif -157 4846: dhim-24thiaz-gly-betahcbph 4847: dhim-25thiaz-ala-betadcph 4848: tolhs-24thioph-gly-betabnaphth 4849: bhs-24thiaz-bala-betahmo 5 4850: ibhs-oxadiaz-bala-betadbph 4851: phhs-25methiaz-bala-betahmo 4852: ibhs-25methiaz-gly-betapy 4853: tolhs-25methiaz-gly-zdapch 4854: phhs-25oxaz-bala-betahcbph 0 4855: tolhs-nme35pyr-bala-betaet 4856: tolhs-ithiadiaz-bala-betapytb 4857: nmhs-24thiaz-gly-betadcph 4858: phhs-25thiaz-gly-betaibph 4859: tolhs-24thiaz-bala-betabph 5 4860: tolhs-25oxaz-bala-betaanaphth 4861: bhs-24thioph-bala-betabthioph 4862: phhs-oxadiaz-gly-betadmoph 4863: bim-me25oxaz-ala-psdap 4864: ibhs-25methiaz-bala-betahdbph 4865: bhs-24thioph-ala-betacph 4866: ibhs-24thioph-bala-betadhbfu 4867: ibhs-nme35pyr-bala-betaipr 4868: bim-25oxaz-bala-zdap 4869: bim-42nmeim-leu-zdap i 4870: ibhs-oxadiaz-gly-betahdbph 4871: phhs-me24oxaz-ala-beta34meoph 4872: bhs-oxadiaz-bala-betahmo 4873: phhs-24thiaz-bala-betadhbfu 4874: bhs-25fur-bala-zdap 4875: tolhs-me25thioph-gly-betapy 4876: ibhs-25thiaz-gly-betafph 4877: 2py-me24thiaz-bala-betapy 4878: phhs-ithiadiaz-bala-beta4bph 4879: phhs-me25thioph-gly-zdap 4880: ibhs-24thioph-bala-betapytb 4881: dhim-26py-gly-betadcph 4882: phhs-25methiaz-gly-betaoxope -158 4883: bhs-25thiaz-bala-betapy 4884: bim-25thiaz-gly-betapbiph 4885: phhs-25thiaz-bala-betahb 4886: bhs-ithiadiaz-gly-beta3quin 5 4887: ibhs-25thiaz-gly-betacthioph 4888: bhs-25methiaz-bala-ibsdap 4889: bim-42pym-ala-betainyl 4890: bhs-24thiaz-bala-betapym 4891: bim-25thiaz-bala-csdap 0 4892: bhs-25oxaz-gly-betamesu 4893: bhs-24thioph-ala-betahmph 4894: ibhs-25methiaz-bala-betahcbph 4895: tolhs-ithiadiaz-bala-psdapch 4896: tolhs-24thiaz-gly-betampy 5 4897: bhs-triaz-bala-psdap 4898: bhs-nme35pyr-gly-betabnaphth 4899: phhs-oxadiaz-bala-betabnaphth 4900: tolhs-25thiaz-bala-betamethioph 4901: tolhs-oxadiaz-gly-betadbph 0 4902: tolhs-nme35pyr-bala-betadhbfu 4903: bhs-24thiaz-ala-betaanaphth 4904: ibhs-25thiaz-gly-betadcphch 4905: bhs-oxadiaz-gly-betapbiph 4906: ibhs-ithiadiaz-gly-betampy 5 4907: tolhs-25thiaz-gly-aspaba 4908: bhs-nme35pyr-bala-betabdimo 4909: tolhs-oxadiaz-gly-betadcphtb 4910: tolhs-oxadiaz-bala-beta3quin 4911: bim-oxadiaz-bala-psdap 3 4912: phhs-25methiaz-bala-beta34meoph 4913: phhs-24thiaz-gly-betaftrif 4914: bhs-nme35pyr-gly-betacbph 4915: ibhs-oxadiaz-bala-suabu 4916: bhs-triaz-bala-betadcph 5 4917: 2py-24oxaz-leu-betapy 4918: dhim-42pym-ala-betainyl 4919: phhs-25oxaz-gly-betaftrif -159 4920: tolhs-25thiaz-bala-betaanaphth 4921: bhs-thiadiaz-bala-psdap 4922: tolhs-24thioph-bala-betainyl 4923: tolhs-25oxaz-gly-betathioph 5 4924: bhs-42pym-ala-betapy 4925: 2py-26py-gly-beta23meoph 4926: phhs-ithiadiaz-gly-betahph 4927: phhs-25methiaz-gly-betapym 4928: ibhs-25methiaz-bala-betacthioph 0 4929: bhs-24thiaz-gly-betabenfu 4930: tolhs-25thiaz-bala-betaphethioa 4931: bhs-25thiaz-gly-ibsdap 4932: ibhs-25thiaz-bala-betainyl 4933: tolhs-24thioph-bala-psdaptb 5 4934: ibhs-24thiaz-bala-betadhbfu 4935: bhs-nme35pyr-bala-betaoxope 4936: tolhs-25methiaz-gly-betal 3bendi 4937: ibhs-24thiaz-gly-beta34dcph 4938: bim-me24oxaz-ala-zdap D 4939: phhs-nme35pyr-bala-betapbiph 4940: dhim-26py-ala-betadcph 4941: phhs-25methiaz-gly-betacthioph 4942: 2py-42nmeim-bala-zdap 4943: ibhs-25thiaz-gly-betahbcph 5 4944: ibhs-25thiaz-gly-betacph 4945: ibhs-25oxaz-gly-betacbph 4946: tolhs-25thiaz-bala-betadcph 4947: dhim-24oxaz-gly-betameph 4948: bhs-nme35pyr-gly-betatrif 4949: bhs-24thioph-bala-betahph 4950: bhs-nme35pyr-bala-aspibua 4951: bhs-25thiaz-gly-betamesu 4952: bim-me24oxaz-bala-betaph 4953: bhs-25oxaz-bala-betahb 4954: bim-ithiadiaz-ala-zdap 4955: phhs-oxadiaz-bala-betabmph 4956: bhs-oxadiaz-ala-betadito -160 4957: phhs-ithiadiaz-bala-betatbuph 4958: bhs-25oxaz-nmgly-betaipro 4959: 2py-25fur-leu-psdap 4960: bhs-ithiadiaz-gly-asppha 5 4961: ibhs-25methiaz-gly-psdapch 4962: tolhs-25thiaz-gly-psdap 4963: bhs-oxadiaz-bala-betaet 4964: bhs-24thioph-bala-betamethioph 4965: bim-24thioph-gly-aspibua 0 4966: phhs-me25thioph-ala-betaph 4967: tolhs-nme35pyr-gly-ibsdap 4968: ibhs-24thioph-bala-beta23meoph 4969: tolhs-oxadiaz-bala-betadhbfu 4970: 2py-25thiaz-gly-betadito 5 4971: phhs-ithiadiaz-gly-betahc 4972: phhs-24thioph-bala-betahbcph 4973: bhs-25methiaz-bala-betah35dc 4974: gua-25thioph-gly-betacph 4975: phhs-oxadiaz-gly-beta23meoph D 4976: ibhs-24thioph-gly-betah35dc 4977: phhs-24thioph-gly-betaanaphth 4978: bim-24thiaz-bala-csdap 4979: 2py-24thiaz-gly-betameph 4980: tolhs-24thioph-bala-betambiph 5 4981: 2py-24im-leu-betadcph 4982: tolhs-nme35pyr-bala-betah35dc 4983: bhs-25oxaz-gly-ibsdap 4984: ibhs-25methiaz-gly-ibsdap 4985: tolhs-ithiadiaz-gly-betameph 4986: bhs-24thiaz-bala-betainyl 4987: bim-me25thiaz-bala-betadcph 4988: tolhs-25methiaz-bala-beta35dbph 4989: bhs-me25oxaz-gly-betaph 4990: phhs-25thiaz-gly-betadhbfu 4991: cima-42nmeim-bala-betapy 4992: phhs-24thiaz-bala-betabthioph 4993: bim-24thioph-leu-psdap -161 4994: tolhs-me25oxaz-bala-beta34meoph 4995: ibhs-oxadiaz-bala-betainyl 4996: ibhs-ithiadiaz-bala-betaipr 4997: tolhs-nme35pyr-bala-betatos 5 4998: 3pmhs-25thioph-gly-betapy 4999: 2py-25thiaz-gly-aspaba 5000: bim-25methiaz-leu-betapy 5001: bim-24thiaz-bala-betadcph 5002: bhs-24thioph-gly-ibsdap 0 5003: 2py-53pyrazo-gly-psdap 5004: ibhs-24thioph-gly-betaamibe 5005: tolhs-me24thiaz-gly-betapy 5006: bhs-52thiaz-gly-betameph 5007: ibhs-ithiadiaz-bala-betathioph 5 5008: ibhs-25thiaz-gly-betadmph 5009: bim-24im-gly-zdap 5010: ibhs-24thioph-bala-psdaptb 5011: bim-24thioph-bala-aspibua 5012: bhs-ithiadiaz-nmgly-betahmph ) 5013: bhs-25thiaz-bala-betainyl 5014: phhs-25methiaz-gly-betacbph 5015: bim-25thiaz-gly-betainyl 5016: phhs-24thioph-gly-betabediox 5017: phhs-oxadiaz-gly-betabnaphth 5 5018: ibhs-nme35pyr-gly-betabediox 5019: phhs-25thiaz-bala-betah35dc 5020: tolhs-nme35pyr-bala-beta34meoph 5021: phhs-me24thiaz-gly-psdap 5022: phhs-24thioph-bala-betabdimo 5023: tolhs-nme35pyr-gly-betaipro 5024: ibhs-25thiaz-gly-betaomebendi 5025: phhs-25oxaz-gly-betabmph 5026: dhim-26py-ala-betainyl 5027: thpym-26py-gly-betacbph 5028: ibhs-24thiaz-bala-betapytb 5029: ibhs-25thiaz-bala-betaimid 5030: ibhs-ithiadiaz-gly-betaol -162 5031: ibhs-oxadiaz-bala-beta34dcph 5032: phhs-me25oxaz-gly-betaph 5033: tolhs-24thioph-bala-betafphe 5034: ibhs-24thioph-bala-betaftrif 5 5035: bim-42pym-ala-betapy 5036: bhs-nme35pyr-ala-betacph 5037: tolhs-nme35pyr-gly-betabenfu 5038: bim-42oxaz-ala-zdap 5039: ibhs-25oxaz-bala-betampy 0 5040: phhs-25thiaz-gly-betafphe 5041: dhim-26py-gly-beta34meoph 5042: ibhs-24thiaz-gly-betathiome 5043: bim-me24thioph-bala-betapy 5044: bim-24im-bala-zdap 5 5045: bhs-ithiadiaz-bala-betahbcph 5046: 2py-25thiaz-gly-betadcph 5047: bim-me25oxaz-bala-betadcph 5048: phhs-25methiaz-bala-betathiobe 5049: ibhs-25oxaz-bala-beta3quin 0 5050: phhs-oxadiaz-bala-beta34meoph 5051: gua-42pym-gly-betabthioph 5052: bhs-35thioph-bala-betapy 5053: 2py-42pym-gly-betainyl 5054: phhs-ithiadiaz-gly-beta4bph 5 5055: bhs-24thioph-bala-betahdcph 5056: ibhs-25methiaz-bala-betahni 5057: bim-25methiaz-leu-psdap 5058: tolhs-me25oxaz-ala-beta34meoph 5059: ibhs-25thiaz-bala-betampy 5060: phhs-25methiaz-gly-betaoxaz 5061: 2pmhs-42pym-gly-betainyl 5062: tolhs-nme35pyr-gly-betapyr 5063: tolhs-25methiaz-bala-betapych 5064: tolhs-oxadiaz-gly-betadito i 5065: tolhs-me25oxaz-ala-psdap 5066: bhs-ithiadiaz-bala-beta3quin 5067: 2py-25oxaz-ala-psdap -163 5068: bim-24thioph-leu-betapy 5069: tolhs-25methiaz-bala-betahmo 5070: bhs-25methiaz-bala-zdapch 5071: bhs-24thiaz-bala-betamethi 5 5072: 2pmhs-24thioph-bala-betamethioph 5073: bim-24thioph-gly-aspaba 5074: ibhs-25methihz-gly-betatrif 5075: bhs-24thioph-gly-beta3quin 5076: ibhs-oxadiaz-gly-betatrif 0 5077: 2py-triaz-bala-betapy 5078: phhs-24thioph-bala-betameph 5079: bim-25oxaz-gly-psdap 5080: tolhs-nme35pyr-bala-betabthioph 5081: tolhs-25thiaz-gly-betahmph 5 5082: bhs-42nmeim-ala-betapy 5083: tolhs-25oxaz-bala-beta34meoph 5084: ibhs-24thiaz-gly-betameph 5085: bim-me24thioph-bala-betadcph 5086: 2py-26py-gly-betabiph 0 5087: ibhs-25thiaz-bala-betaheph 5088: bhs-25thiaz-nmgly-betadhbfu 5089: tolhs-oxadiaz-gly-betameph 5090: bhs-nme35pyr-nmgly-beta34meoph 5091: dhpyrr-24thiaz-gly-betapy 5 5092: tolhs-25oxaz-bala-betathioph 5093: bhs-24thiaz-bala-betaipro 5094: bhs-25oxaz-ala-betamesu 5095: ibhs-24thioph-gly-betathiobe 5096: nmhs-25methiaz-gly-betadcph 5097: phhs-24thiaz-gly-aspibua 5098: bhs-oxadiaz-gly-betapytb 5099: bim-24thiaz-bala-psdap 5100: ibhs-nme35pyr-bala-betabenfu 5101: ibhs-24thiaz-bala-betaomebendi 5102: ibhs-25thiaz-bala-betabnaphth 5103: 2py-25oxaz-leu-betapy 5104: phhs-ithiadiaz-gly-aspbzla -164 5105: ibhs-25thiaz-bala-betabdimo 5106: 2py-me24thioph-gly-betadcph 5107: tolhs-oxadiaz-bala-betaipro 5108: ibhs-24thiaz-bala-betahmph 5 5109: bhs-25thiaz-gly-aspaba 5110: 2py-35thioph-ala-betapy 5111: bhs-24thioph-gly-zdaptb 5112: phhs-nme35pyr-gly-betatrif 5113: tolhs-25oxaz-gly-betaphethioa 0 5114: thazep-24thiaz-gly-betadcph 5115: tolhs-ithiadiaz-gly-betadcphch 5116: phhs-25oxaz-bala-betafbph 5117: tolhs-25methiaz-gly-betamethioph 5118: impy-24thiaz-gly-betambiph 5 5119: phhs-oxadiaz-bala-betafu3 5120: tolhs-me24thiaz-leu-zdap 5121: ibhs-ithiadiaz-bala-betabediox 5122: bhs-oxadiaz-gly-betahc 5123: tolhs-24thiaz-gly-betahmph 0 5124: bhs-oxadiaz-bala-zdap 5125: bhs-oxadiaz-bala-betahbcph 5126: bim-24thiaz-gly-psdap 5127: bhs-24thiaz-ala-betampy 5128: 2pmhs-25oxaz-gly-beta35dbph 5 5129: bhs-26py-gly-betainyl 5130: bhs-nme35pyr-bala-betapym 5131: 2py-26py-met-zdap 5132: ibhs-25oxaz-bala-betacthioph 5133: impy-24thioph-gly-betabthioph D 5134: tolhs-oxadiaz-gly-betahdcph 5135: bhs-24thiaz-gly-betapych 5136: bhs-oxadiaz-ala-psdap 5137: phhs-24thiaz-gly-betadcphee 5138: phhs-oxadiaz-gly-betaibph 5 5139: ibhs-25oxaz-bala-betadhbfu 5140: ibhs-25thiaz-bala-betathiobe 5141: bhs-nme35pyr-ala-betadcph -165 5142: bhs-25oxaz-bala-betampy 5143: 2py-26py-ala-betainyl 5144: tolhs-25oxaz-bala-betal 3bendi 5145: tolhs-nme35pyr-bala-betahmo 5 5146: bhs-nme35pyr-gly-betadbph 5147: bim-me25thioph-bala-psdap 5148: bhs-25oxaz-ala-beta34dcph 5149: ibhs-nme35pyr-gly-zdaptb 5150: tolhs-25methiaz-bala-betamethi D 5151: bhs-nme35pyr-gly-betal 3bendi 5152: 2py-me25thioph-leu-psdap 5153: ibhs-24thioph-bala-betatbuph 5154: sabhs-24thiaz-gly-psdap 5155: bhs-25thiaz-bala-betahmph 5 5156: bim-triaz-gly-betapy 5157: phhs-24thioph-bala-betamethioph 5158: phhs-nme35pyr-bala-psdaptb 5159: dhim-24py-gly-betameph 5160: cima-25thiaz-bala-psdap 3 5161: bhs-24thiaz-gly-betampy 5162: tolhs-25methiaz-bala-beta23meoph 5163: 2py-ithiadiaz-ala-betapy 5164: impy-25methiaz-gly-betabthioph 5165: ibhs-24thioph-bala-betaoxope 5 5166: tolhs-me25thiaz-gly-beta34meoph 5167: ibhs-nme35pyr-gly-betamethi 5168: ibhs-nme35pyr-gly-betabpy 5169: tolhs-25methiaz-bala-betaph 5170: tolhs-24thioph-gly-betapyr 5171: ibhs-25oxaz-bala-betahph 5172: bim-24thiaz-bala-betafphe 5173: tolhs-me24thioph-gly-betadcph 5174: bhs-ithiadiaz-gly-psdapch 5175: 2py-24thiaz-bala-betapy 5 5176: tolhs-nme35pyr-bala-betaipro 5177: bhs-24thioph-nmgly-beta23meoph 5178: bim-52thiaz-gly-betadcph -166 5179: gua-24oxaz-gly-betathioph 5180: bhs-triaz-gly-betadcph 5181: bim-42nmeim-bala-betaipr 5182: tolhs-25thiaz-gly-betapym 5 5183: phhs-25thiaz-bala-betadcphch 5184: phhs-ithiadiaz-gly-betafu2 5185: phhs-ithiadiaz-bala-betampy 5186: phhs-ithiadiaz-gly-betadcphtb 5187: dhim-26py-ala-betapy 0 5188: phhs-oxadiaz-gly-betamesu 5189: ibhs-25methiaz-bala-psdapee 5190: phhs-me24thioph-gly-zdap 5191: ibhs-25oxaz-gly-betadmph 5192: bhs-25methiaz-gly-betadcphee 5 5193: bim-oxadiaz-ala-psdap 5194: phhs-ithiadiaz-gly-betaamibe 5195: 2py-me25oxaz-gly-betaph 5196: phhs-25oxaz-bala-aspaba 5197: bim-me25oxaz-leu-zdap 0 5198: 2py-25thiaz-bala-betafluo 5199: ibhs-24thioph-gly-betafphe 5200: bim-25thiaz-bala-betapy 5201: bhs-24thioph-bala-betatos 5202: gua-25thiaz-gly-betabdimo 5 5203: 2py-42oxaz-ala-betadcph 5204: bhs-ithiadiaz-gly-betamethioph 5205: tolhs-me25thioph-leu-betapy 5206: bhs-25thiaz-ala-psdap 5207: ibhs-25thiaz-bala-betaoxope 0 5208: bhs-25oxaz-bala-betahmph 5209: bhs-25thiaz-gly-betabthioph 5210: tolhs-24thioph-gly-betabenfu 5211: phhs-me25thioph-leu-betaph 5212: tolhs-25thiaz-gly-ibsdap 5 5213: phhs-24thioph-gly-betahni 5214: bhs-24thioph-gly-betaipr 5215: tolhs-me25oxaz-ala-betapy -167 5216: phhs-me24thioph-bala-zdap 5217: bhs-25oxaz-bala-betathioph 5218: ibhs-ithiadiaz-gly-zdaptb 5219: ibhs-24thioph-bala-betahmo 5 5220: tolhs-25methiaz-gly-betabthioph 5221: tolhs-nme35pyr-gly-betaibph 5222: tolhs-me24thioph-gly-zdap 5223: phhs-24thiaz-gly-ibsdap 5224: tolhs-25thiaz-gly-betahbcph 0 5225: ibhs-oxadiaz-bala-betafph 5226: bhs-oxadiaz-nmgly-betahmph 5227: impy-42nmeim-bala-betameph 5228: gua-25thiaz-gly-betadcph 5229: phhs-oxadiaz-gly-betapym 5 5230: bhs-24thioph-gly-betabmph 5231: phhs-24thioph-gly-aspibua 5232: bhs-25oxaz-ala-betahph 5233: ibhs-24thiaz-gly-asppha 5234: 2py-42oxaz-gly-zdap 0 5235: phhs-me24thiaz-gly-beta34meoph 5236: bhs-nme35pyr-bala-betamethi 5237: bhs-25oxaz-bala-betaheph 5238: dhim-25thiaz-ala-betameph 5239: bhs-ithiadiaz-gly-beta35dbph 5 5240: bim-oxadiaz-ala-betapy 5241: ibhs-nme35pyr-bala-betafu3 5242: phhs-ithiadiaz-gly-betabpy 5243: tolhs-ithiadiaz-gly-betah35dc 5244: 2py-me25thiaz-ala-psdap 5245: bim-24im-ala-zdap 5246: bim-me25oxaz-gly-beta34meoph 5247: bhs-oxadiaz-bala-betapbiph 5248: bhs-24thioph-gly-beta4bph 5249: ibhs-25methiaz-bala-betaibph i 5250: ibhs-24thiaz-gly-betatbuph 5251: bhs-oxadiaz-nmgly-betaanaphth 5252: phhs-25thiaz-gly-betamethi -168 5253: ibhs-ithiadiaz-gly-betadcphtb 5254: tolhs-24thioph-bala-betaet 5255: bhs-25methiaz-bala-beta34meoph 5256: ibhs-25thiaz-bala-suabu 5 5257: 2py-42nmeim-gly-betapy 5258: tolhs-25thiaz-bala-betahmph 5259: bhs-25thiaz-gly-betahni 5260: 2pmhs-42nmeim-bala-betaphethio 5261: tolhs-25methiaz-gly-betadbph 0 5262: ibhs-25thiaz-gly-betamethioph 5263: bhs-25thiaz-nmala-betameph 5264: 2py-25methiaz-ala-betadcph 5265: bim-35fur-gly-betadcph 5266: bhs-oxadiaz-gly-betabenf u 5 5267: 2py-oxadiaz-gly-betadcph 5268: bhs-25oxaz-bala-betaph 5269: phhs-24thioph-gly-betamethioph 5270: phhs-oxadiaz-bala-betafu2 5271: bhs-25methiaz-gly-betaoxaz 0 5272: tolhs-25thiaz-bala-betacbph 5273: tolhs-25oxaz-gly-betah35dc 5274: ibhs-24thiaz-gly-aspaba 5275: bim-25oxaz-bala-aspbzla 5276: tolhs-oxadiaz-bala-betahmofu 5 5277: bhs-25oxaz-bala-csdap 5278: tolhs-oxadiaz-gly-zdaptb 5279: phhs-25thiaz-bala-beta34dcph 5280: phhs-24thioph-bala-betambiph 5281: tolhs-24thiaz-gly-betabthioph 0 5282: bhs-24thiaz-bala-betaomebendi 5283: phhs-25thiaz-bala-beta35dbph 5284: ibhs-25methiaz-bala-aspbzla 5285: bhs-24thioph-ala-beta23meoph 5286: bhs-nme35pyr-bala-csdap 5 5287: phhs-24thiaz-bala-betafu3 5288: ibhs-25methiaz-gly-betaimid 5289: ibhs-24thiaz-gly-betafph -169 5290: impy-25oxaz-bala-betabenfu 5291: bhs-25thiaz-bala-suabu 5292: phhs-24thioph-gly-betabdimo 5293: tolhs-me24thioph-bala-psdap 5 5294: ibhs-24thioph-gly-betabenfu 5295: bim-35fur-ala-betapy 5296: bhs-25oxaz-bala-suabu 5297: bhs-25thiaz-bala-betamethi 5298: bhs-oxadiaz-bala-betabpy 0 5299: gua-24thiaz-gly-betaamibe 5300: bhs-25methiaz-bala-betathioph 5301: phhs-me25thiaz-gly-betadcph 5302: bhs-24thiaz-bala-ibsdap 5303: ibhs-25thiaz-bala-aspaba 5 5304: tolhs-ithiadiaz-bala-betaheph 5305: bhs-25oxaz-nmgly-betahph 5306: tolhs-24thioph-gly-betaol 5307: bhs-25methiaz-bala-betapych 5308: 2py-42nmeim-bala-betaomebendi D 5309: bhs-25methiaz-bala-betabthioph 5310: bhs-25thiaz-bala-betaimid 5311: tolhs-24thiaz-gly-betahb 5312: ibhs-ithiadiaz-bala-betacph 5313: ibhs-25oxaz-gly-asppha 5 5314: phhs-25thiaz-gly-betahdbph 5315: tolhs-ithiadiaz-gly-betacthioph 5316: bhs-ithiadiaz-ala-betal 3bendi 5317: tolhs-25oxaz-gly-betabph 5318: ibhs-25thiaz-bala-betaomebendi 5319: bhs-ithiadiaz-gly-ibsdap 5320: ibhs-24thiaz-gly-betapyee 5321: tolhs-24thioph-bala-betathiobe 5322: bhs-ithiadiaz-gly-betapyee 5323: ibhs-24thioph-gly-betadito i 5324: bim-me24oxaz-leu-beta34meoph 5325: tolhs-24thiaz-bala-busu2be 5326: bhs-25thiaz-gly-betaoxaz -170 5327: ibhs-nme35pyr-gly-aspaba 5328: ibhs-nme35pyr-bala-betatrif 5329: bhs-25oxaz-bala-betafph 5330: tolhs-25oxaz-bala-betacbph 5 5331: 2py-oxadiaz-ala-betadcph 5332: phhs-24thiaz-bala-busu2be 5333: tolhs-25methiaz-gly-betainyl 5334: phhs-nme35pyr-bala-betafu3 5335: bhs-24thiaz-gly-betaphethioa D 5336: ibhs-25oxaz-gly-aspibua 5337: tolhs-24thiaz-gly-betaphethioa 5338: 2py-25methiaz-gly-beta35dbph 5339: ibhs-nme35pyr-gly-betahb 5340: 2py-25thiaz-bala-betadcph 5 5341: 2py-me24thioph-leu-zdap 5342: phhs-nme35pyr-gly-betaipr 5343: bhs-25oxaz-nmgly-betacph 5344: tolhs-oxadiaz-bala-beta4bph 5345: bhs-24thioph-ala-betadcph 3 5346: phhs-25thiaz-gly-beta1 3bendi 5347: tolhs-oxadiaz-gly-suabu 5348: bhs-25oxaz-bala-betapyee 5349: tolhs-25thiaz-bala-aspbzla 5350: tolhs-24thiaz-gly-betahcbph 5 5351: ibhs-oxadiaz-bala-betatrif 5352: bhs-24thiaz-bala-zdap 5353: ibhs-ithiadiaz-bala-betapyee 5354: 2py-42nmeim-leu-betadcph 5355: bim-42pym-gly-betameph 5356: tolhs-25oxaz-gly-betafph 5357: phhs-25oxaz-bala-betahmo 5358: bhs-25thioph-ala-betainyl 5359: phhs-25methiaz-gly-betaftrif 5360: bim-25oxaz-bala-betapy 5 5361: ibhs-nme35pyr-gly-betaol 5362: 2py-25methiaz-gly-betatbuph 5363: bhs-25thiaz-bala-betadmoph -171 5364: tolhs-24thioph-bala-csdap 5365: ibhs-oxadiaz-gly-betal 3bendi 5366: tolhs-nme35pyr-gly-betampy 5367: bhs-25oxaz-bala-betaoxaz 5 5368: bhs-nme35pyr-nmgly-betafphe 5369: tolhs-nme35pyr-bala-betadcph 5370: tolhs-nme35pyr-bala-betadmoph 5371: 2py-25thiaz-gly-betapy 5372: dhim-42pym-ala-betameph 0 5373: bhs-24thiaz-bala-betapy 5374: phhs-oxadiaz-bala-betaimid 5375: ibhs-ithiadiaz-gly-betahmph 5376: tolhs-24thioph-bala-zdapch 5377: 2py-24oxaz-ala-psdap 5 5378: ibhs-ithiadiaz-gly-betambiph 5379: bim-nme35pyr-bala-psdap 5380: bim-25fur-leu-betadcph 5381: bhs-oxadiaz-bala-psdap 5382: phhs-25methiaz-bala-betaipr 0 5383: bhs-me25thiaz-ala-zdap 5384: ibhs-ithiadiaz-bala-betameph 5385: bhs-25oxaz-gly-betal 3bendi 5386: tolhs-nme35pyr-bala-betabdimo 5387: ibhs-oxadiaz-bala-betahc 5 5388: bhs-25oxaz-bala-beta34dcph 5389: ibhs-25thiaz-bala-betadhbfu 5390: bhs-25methiaz-gly-betatrif 5391: ibhs-24thiaz-bala-betafu2 5392: phhs-ithiadiaz-gly-betabediox 5393: bhs-me25thioph-gly-betapy 5394: bhs-me25oxaz-ala-betadcph 5395: bhs-24thiaz-gly-betaphethio 5396: tolhs-24thiaz-bala-betadtrif 5397: bhs-ithiadiaz-nmgly-betaanaphth i 5398: phhs-24thiaz-bala-betadcphtb 5399: bhs-ithiadiaz-ala-betacph 5400: thpym-24thioph-bala-psdap -172 5401: bhs-25oxaz-ala-betathioph 5402: bim-25methiaz-nmala-betadcph 5403: tolhs-25methiaz-gly-betahc 5404: bhs-25py-gly-betapy 5 5405: bim-me24thiaz-leu-zdap 5406: ibhs-oxadiaz-bala-betapyee 5407: phhs-me25oxaz-bala-betaph 5408: phhs-ithiadiaz-bala-betahmofu 5409: ibhs-25oxaz-bala-betafbph 0 5410: phhs-ithiadiaz-gly-betabmph 5411: phhs-25thiaz-gly-betabthioph 5412: ibhs-25methiaz-gly-aspibua 5413: tolhs-25thiaz-gly-psdapee 5414: bim-25thioph-ala-psdap 5 5415: bhs-ithiadiaz-nmgly-beta23meoph 5416: bhs-24thiaz-gly-betahb 5417: tolhs-25thiaz-gly-betamethi 5418: tolhs-oxadiaz-bala-betapych 5419: bim-25methiaz-ala-psdap 0 5420: bhs-me24oxaz-leu-betapy 5421: tolhs-25methiaz-gly-beta4bph 5422: dhim-26py-gly-betapy 5423: ibhs-oxadiaz-gly-asppha 5424: 2py-24thiaz-leu-betadcph 5 5425: tolhs-oxadiaz-bala-betabmph 5426: bhs-oxadiaz-bala-betafu2 5427: bhs-25methiaz-bala-betaipro 5428: tolhs-25methiaz-gly-betapych 5429: phhs-25thiaz-bala-beta4bph D 5430: bim-thiadiaz-leu-betadcph 5431: tolhs-24thiaz-gly-betabmph 5432: gua-42pym-gly-betaheph 5433: phhs-ithiadiaz-bala-betaipr 5434: 2pmhs-25thiaz-bala-betapyr 5 5435: tolhs-me24thioph-leu-betadcph 5436: bhs-oxadiaz-gly-betamethi 5437: phhs-24thiaz-bala-betathiome -173 5438: ibhs-nme35pyr-bala-betamethioph 5439: tolhs-me24thiaz-ala-psdap 5440: tolhs-24thioph-gly-betadito 5441: bhs-24thiaz-bala-betahdcph 5 5442: phhs-24thiaz-gly-betathiobe 5443: bim-42pym-ala-betameph 5444: phhs-24thiaz-gly-zdaptb 5445: bhs-24thiaz-gly-csdap 5446: bhs-oxadiaz-bala-betadtrif 3 5447: 2py-42oxaz-ala-psdap 5448: phhs-oxadiaz-bala-beta4bph 5449: bhs-oxadiaz-gly-betahdbph 5450: gua-26py-gly-beta4bph 5451: bhs-26pyrazi-ala-betapy 5 5452: tolhs-24thiaz-gly-psdaptb 5453: bhs-42nmeim-gly-betaheph 5454: ibhs-ithiadiaz-bala-betatbuph 5455: ibhs-24thioph-bala-betatrif 5456: phhs-25methiaz-gly-betaph 5457: bim-me24thioph-bala-zdap 5458: ibhs-oxadiaz-bala-betabthioph 5459: bhs-me24oxaz-leu-psdap 5460: tolhs-24thiaz-gly-betapych 5461: phhs-25thiaz-gly-betaol 5462: bhs-me24im-gly-zdap 5463: bim-25oxaz-gly-betathiome 5464: impy-25oxaz-bala-betaamibe 5465: tolhs-25methiaz-bala-asppha 5466: ibhs-24thioph-bala-betahdcph 5467: ibhs-25methiaz-bala-busu2be 5468: bhs-24thiaz-bala-betabmph 5469: bhs-me25thioph-gly-psdap 5470: ibhs-24thiaz-bala-betafluo 5471: dhim-24thiaz-ala-betapy 5472: bim-25thioph-leu-betadcph 5473: thpym-24thiaz-bala-psdap 5474: bhs-25oxaz-bala-betameph -174 5475: bhs-24thiaz-gly-betaoxaz 5476: bim-24thiaz-ala-psdap 5477: phhs-24thiaz-bala-betaoxaz 5478: bhs-ithiadiaz-bala-betahb 5 5479: bhs-ithiadiaz-bala-zdapee 5480: bhs-25oxaz-nmgly-betaoxaz 5481: bhs-25thiaz-nmgly-betadito 5482: bhs-nme35pyr-gly-psdapch 5483: ibhs-nme35pyr-gly-betadbph 0 5484: phhs-me24oxaz-leu-zdap 5485: bhs-oxadiaz-bala-betaoxaz 5486: bhs-oxadiaz-gly-betadito 5487: gua-42pym-gly-betathiobe 5488: bim-42nmeim-ala-betadcph 5 5489: bhs-42nmeim-gly-betabnaphth 5490: phhs-ithiadiaz-bala-betapytb 5491: 2py-ithiadiaz-bala-aspbzla 5492: bhs-24thioph-gly-betafbph 5493: bhs-oxadiaz-bala-betaanaphth 0 5494: bhs-me24oxaz-bala-betaph 5495: phhs-25thiaz-bala-betacthioph 5496: tolhs-25methiaz-bala-betapyee 5497: bhs-25methiaz-gly-beta35dbph 5498: phhs-me24oxaz-gly-betapy 5 5499: ibhs-25methiaz-bala-betaph 5500: 2py-24oxaz-bala-betapy 5501: ibhs-ithiadiaz-gly-aspibua 5502: phhs-25thiaz-gly-betadcphee 5503: bhs-24pym-gly-zdap D 5504: tolhs-24thiaz-gly-betathioph 5505: tolhs-ithiadiaz-bala-betadcphch 5506: 2py-ithiadiaz-leu-betadcph 5507: phhs-24thiaz-bala-betapyee 5508: phhs-ithiadiaz-bala-betadcph 5 5509: bhs-25oxaz-bala-betamethioph 5510: 2py-53pyrazo-leu-betapy 5511: ibhs-25oxaz-gly-betadcph -175 5512: ibhs-oxadiaz-gly-csdap 5513: bim-25methiaz-ala-betadcph 5514: phhs-25methiaz-bala-betamethioph 5515: bhs-oxadiaz-bala-psdaptb 5 5516: 2py-me25thiaz-gly-betapy 5517: tolhs-25thiaz-gly-betacph 5518: impy-42nmeim-gly-betapyr 5519: bim-25methiaz-bala-betafphe 5520: phhs-25oxaz-gly-betapytb 0 5521: ibhs-25oxaz-gly-betapbiph 5522: 2py-me25oxaz-bala-psdap 5523: bhs-ithiadiaz-bala-zdaptb 5524: 2py-25methiaz-bala-betafluo 5525: bhs-25thiaz-gly-betacthioph 5 5526: bhs-nme35pyr-bala-beta35dbph 5527: bhs-25oxaz-bala-betadcph 5528: tolhs-25thiaz-gly-betahdbph 5529: phhs-25thiaz-bala-betafph 5530: bhs-25thiaz-bala-betahdcph 3 5531: bhs-ithiadiaz-gly-betafu3 5532: bhs-25thiaz-bala-betapym 5533: bhs-ithiadiaz-ala-beta23meoph 5534: ibhs-nme35pyr-bala-betapych 5535: bhs-me25oxaz-bala-betapy 5 5536: 2py-nme35pyr-bala-asppha 5537: 2py-35thioph-bala-betapy 5538: phhs-nme35pyr-bala-betadcphee 5539: tolhs-25oxaz-bala-betabpy 5540: bhs-24thioph-bala-betacthioph 3 5541: bhs-24thioph-ala-betabpy 5542: bim-24im-leu-betadcph 5543: bhs-oxadiaz-gly-betamesu 5544: bhs-thiadiaz-gly-betadcph 5545: tolhs-25thiaz-bala-betameph 5546: bhs-thiadiaz-ala-psdap 5547: bhs-24thioph-bala-betadcphch 5548: bhs-ithiadiaz-gly-betabenfu -176 5549: ibhs-nme35pyr-bala-betadcphee 5550: bhs-me25oxaz-leu-betaph 5551: bhs-me24thiaz-leu-betadcph 5552: tolhs-25thiaz-gly-betatbuph 5 5553: gua-25thioph-gly-betacbph 5554: phhs-25methiaz-gly-betahph 5555: 2py-me25thiaz-bala-psdap 5556: bhs-25methiaz-nmgly-betabpy 5557: bhs-oxadiaz-nmgly-betameph 0 5558: tolhs-24thiaz-gly-betacthioph 5559: dimethpyin-24thioph-gly-betameph 5560: ibhs-25oxaz-bala-betameph 5561: bhs-24thioph-bala-aspbzla 5562: ibhs-24thioph-bala-betabediox 5 5563: tolhs-25oxaz-bala-betaphethioa 5564: ibhs-24thiaz-gly-betabpy 5565: tolhs-25oxaz-bala-betacthioph 5566: tolhs-24thioph-bala-betapbiph 5567: ibhs-oxadiaz-bala-betahbcph ) 5568: phhs-oxadiaz-bala-betatrif 5569: bhs-25oxaz-bala-betabmph 5570: ibhs-oxadiaz-gly-betameph 5571: phhs-ithiadiaz-bala-betathiome 5572: tolhs-ithiadiaz-bala-betacthioph 5 5573: phhs-24thiaz-bala-betaftrif 5574: ibhs-ithiadiaz-bala-betamethi 5575: ibhs-ithiadiaz-gly-betabenfu 5576: ibhs-24thioph-gly-betahdcph 5577: phhs-me25thioph-bala-betaph 5578: 2py-oxadiaz-gly-aspbzla 5579: bhs-24thiaz-nmgiy-betameph 5580: tolhs-oxadiaz-bala-betadtrif 5581: bhs-oxadiaz-bala-beta3quin 5582: hs-25thioph-gly-betapy 5583: 2py-53pyrazo-gly-betapy 5584: bhs-me25thiaz-leu-beta34meoph 5585: bgua-25thiaz-gly-betapy -177 5586: tolhs-nme35pyr-gly-betahni 5587: tolhs-25thiaz-gly-betafphe 5588: bhs-ithiadiaz-bala-csdap 5589: dhim-24thiaz-gly-betadtrif 5 5590: bim-24thiaz-bala-aspaba 5591: phhs-25thiaz-bala-betaheph 5592: bhs-24thiaz-gly-betal 3bendi 5593: ibhs-25oxaz-bala-betathioph 5594: phhs-25methiaz-gly-betafu3 0 5595: tolhs-ithiadiaz-gly-betamethioph 5596: 2 py-42nmeim-gly-betatos 5597: ibhs-25oxaz-bala-betapyr 5598: ibhs-nme35pyr-bala-betamethi 5599: bhs-24thioph-bala-betaheph 5 5600: ibhs-24thiaz-bala-betadcphtb 5601: phhs-25thiaz-gly-betaheph 5602: ibhs-nme35pyr-bala-betaphethio 5603: ibhs-25methiaz-gly-betathio3 5604: tolhs-nme35pyr-gly-betaol 3 5605: tolhs-24thioph-gly-suabu 5606: bhs-25oxaz-gly-beta35dbph 5607: tolhs-24thiaz-gly-aspbzia 5608: bhs-24thioph-nmgly-betameph 5609: tolhs-ithiadiaz-bala-betahni i 5610: bhs-25oxaz-gly-busu2be 5611: phhs-me25thioph-gly-beta34meoph 5612: bhs-24thiaz-gly-betadcphtb 5613: bim-26py-gly-betapy 5614: 2py-me24thiaz-ala-betaph 5615: 2py-me24oxaz-bala-betadcph 5616: bhs-25methiaz-gly-betahni 5617: bhs-25methiaz-gly-betabph 5618: bhs-24thiaz-bala-betafphe 5619: tolhs-ithiadiaz-bala-betafbph 5620: ibhs-oxadiaz-gly-betahc 5621: phhs-nme35pyr-baia-betabmph 5622: bhs-25methiaz-bala-betaimid -178 5623: tolhs-oxadiaz-bala-betadbph 5624: bhs-25methiaz-gly-beta34dcph 5625: bhs-ithiadiaz-nmgly-betainyl 5626: bhs-25methiaz-gly-zdap 5 5627: gua-25thioph-gly-betal 3bendi 5628: phhs-24thiaz-bala-betaibph 5629: bhs-24thioph-bala-betamethi 5630: bim-me24oxaz-ala-betapy 5631: phhs-24thioph-bala-betahmo 0 5632: ibhs-24thioph-gly-betahmo 5633: tolhs-oxadiaz-bala-betafph 5634: ibhs-25oxaz-gly-betafluo 5635: phhs-25thiaz-gly-betaipro 5636: 2py-thiadiaz-ala-zdap 5 5637: tolhs-ithiadiaz-gly-betadcphtb 5638: ibhs-25thiaz-bala-betahb 5639: phhs-me24thioph-gly-betaph 5640: phhs-oxadiaz-gly-betapy 5641: tolhs-nme35pyr-gly-betathio3 0 5642: bhs-25methiaz-gly-betafphe 5643: bhs-nme35pyr-bala-betatrif 5644: phhs-nme35pyr-bala-betaheph 5645: bim-25thiaz-bala-asppha 5646: 2py-25thiaz-bala-beta34dcph 5 5647: bhs-24thiaz-gly-suabu 5648: ibhs-24thioph-bala-betafbph 5649: tolhs-25thiaz-bala-zdapee 5650: tolhs-ithiadiaz-bala-ibsdap 5651: bhs-25methiaz-gly-betaphethio 0 5652: ibhs-25oxaz-gly-betapym 5653: phhs-25oxaz-bala-betahb 5654: ibhs-ithiadiaz-gly-betainyl 5655: tolhs-me24thiaz-leu-psdap 5656: ibhs-25oxaz-bala-betathio3 5 5657: 2py-53pyrazo-leu-psdap 5658: tolhs-nme35pyr-bala-betacph 5659: ibhs-25thiaz-bala-betafu2 -179 5660: ibhs-25methiaz-gly-betadcphch 5661: bhs-me24oxaz-ala-zdap 5662: phhs-24thiaz-bala-beta34meoph 5663: tolhs-nme35pyr-bala-betathiobe 5 5664: phhs-me24thioph-gly-psdap 5665: tolhs-25oxaz-gly-betabpy 5666: 2py-25oxaz-gly-asppha 5667: ibhs-25methiaz-gly-betacbph 5668: bhs-25methiaz-bala-beta3quin 0 5669: tolhs-24thioph-gly-beta23meoph 5670: tolhs-nme35pyr-gly-betahcbph 5671: ibhs-25thiaz-bala-betaphethioa 5672: phhs-nme35pyr-gly-betafphe 5673: bhs-ithiadiaz-gly-betabediox 5 5674: ibhs-24thiaz-gly-betahdbph 5675: tolhs-25methiaz-bala-betathioph 5676: tolhs-nme35pyr-bala-betamethi 5677: tolhs-25thiaz-gly-betabenfu 5678: gua-24thiaz-gly-betabdimo D 5679: phhs-24thiaz-bala-psdapee 5680: phhs-oxadiaz-gly-psdapch 5681: phhs-25oxaz-gly-betahdcph 5682: ibhs-24thioph-bala-betapym 5683: tolhs-25thiaz-gly-betahb 5 5684: bhs-42nmeim-gly-betaet 5685: bim-me25thioph-ala-betapy 5686: bim-25thiaz-leu-betadcph 5687: bhs-25thiaz-bala-betapyee 5688: ibhs-25methiaz-bala-betahmo 5689: phhs-25oxaz-gly-betacbph 5690: dhim-42pym-ala-zdap 5691: bhs-oxadiaz-gly-betathioph 5692: tolhs-25oxaz-gly-betahmo 5693: phhs-24thiaz-gly-betaipr 5694: tolhs-me24oxaz-leu-betapy 5695: phhs-oxadiaz-gly-betapytb 5696: ibhs-25methiaz-gly-beta35dbph -180 5697: bhs-ithiadiaz-gly-betadhbfu 5698: phhs-25thiaz-gly-busu2be 5699: bhs-nme35pyr-bala-betambiph 5700: bim-24thioph-gly-betapy 5 5701: ibhs-nme35pyr-gly-betadcphtb 5702: bim-25methiaz-gly-psdap 5703: phhs-nme35pyr-bala-betaipr 5704: gua-25thiaz-gly-betainyl 5705: bhs-25oxaz-bala-betafluo 0 5706: gua-25thioph-gly-betahmph 5707: tolhs-24thioph-gly-betainyl 5708: bhs-24thioph-bala-betaet 5709: tolhs-25oxaz-bala-betafu3 5710: 2py-24thiaz-bala-beta34dcph 5 5711: gua-42pym-gly-betaph 5712: tolhs-ithiadiaz-gly-betahni 5713: 2py-42nmeim-leu-psdap 5714: 2py-24thiaz-hphe-psdap 5715: phhs-nme35pyr-gly-zdapee 0 5716: bhs-26py-ala-betapy 5717: ibhs-25methiaz-gly-betabph 5718: bhs-25methiaz-bala-betaphethioa 5719: tolhs-me25thiaz-ala-zdap 5720: bhs-24thioph-bala-beta3quin 5 5721: dhim-25thioph-ala-betainyl 5722: phhs-oxadiaz-gly-betahph 5723: tolhs-25oxaz-gly-betatbuph 5724: bhs-oxadiaz-gly-betaphethio 5725: bim-me24oxaz-ala-betaph 5726: tolhs-me25thiaz-leu-beta34meoph 5727: bim-24im-bala-betapy 5728: phhs-ithiadiaz-bala-betahb 5729: tolhs-25methiaz-gly-beta35dbph 5730: ibhs-25thiaz-bala-betadcphee 5731: ibhs-oxadiaz-bala-beta23meoph 5732: gua-24oxaz-gly-betatrif 5733: 2py-25thioph-ala-zdap -181 5734: bhs-42oxaz-leu-betadcph 5735: bhs-triaz-bala-betapy 5736: phhs-25methiaz-bala-beta34dcph 5737: tolhs-ithiadiaz-gly-betabediox 5 5738: phhs-oxadiaz-bala-betal 3bendi 5739: ibhs-25thiaz-bala-betahmo 5740: tolhs-25methiaz-bala-betadhbfu 5741: 2py-me24oxaz-leu-betapy 5742: phhs-ithiadiaz-bala-betafluo 0 5743: tolhs-24thioph-bala-betathiome 5744: bhs-52thiaz-gly-psdap 5745: tolhs-oxadiaz-gly-betabediox 5746: bhs-ithiadiaz-ala-betabnaphth 5747: phhs-oxadiaz-bala-betaamibe 5 5748: ibhs-oxadiaz-bala-betadcphch 5749: phhs-24thioph-bala-betafu2 5750: bhs-itbiadiaz-bala-betaoxope 5751: phhs-25oxaz-gly-betaoxaz 5752: ibhs-oxadiaz-bala-betaphethio 3 5753: bhs-25methiaz-nmgly-beta34meoph 5754: bhs-nme35pyr-gly-betadcph 5755: 2py-24oxaz-gly-betapy 5756: tolhs-25thiaz-bala-psdapch 5757: bhs-25thiaz-bala-betaoxaz 5 5758: bhs-24oxaz-gly-betameph 5759: bhs-24thioph-ala-betathioph 5760: ibhs-25oxaz-bala-betaipro 5761: phhs-ithiadiaz-bala-betambiph 5762: phhs-24thioph-bala-betaibph 5763: ibhs-ithiadiaz-bala-betadito 5764: tolhs-ithiadiaz-bala-betadcphee 5765: tolhs-oxadiaz-gly-aspbzla 5766: phhs-nme35pyr-gly-betaoxaz 5767: bhs-42nmeim-gly-beta34dcph i 5768: ibhs-oxadiaz-gly-betadito 5769: bhs-nme35pyr-gly-betahbcph 5770: tolhs-24thioph-bala-betamethioph -182 5771: bhs-25methiaz-gly-beta23meoph 5772: bhs-25methiaz-ala-betahmph 5773: ibhs-25methiaz-bala-betadcphtb 5774: tolhs-24thioph-gly-betadbph 5 5775: tolhs-ithiadiaz-bala-betaet 5776: ibhs-ithiadiaz-gly-beta3quin 5777: 2pmhs-42nmeim-met-betapy 5778: ibhs-24thioph-gly-betafph 5779: ibhs-ithiadiaz-gly-betadbph 0 5780: phhs-25thiaz-bala-beta34meoph 5781: phhs-25oxaz-bala-betamesu 5782: bim-24thiaz-bala-betampy 5783: ibhs-25methiaz-bala-beta34meoph 5784: phhs-oxadiaz-gly-aspibua 5 5785: 2py-me24oxaz-bala-betaph 5786: bhs-24im-leu-betapy 5787: ibhs-25thiaz-gly-betampy 5788: 2py-me24thiaz-gly-beta34meoph 5789: ibhs-25methiaz-bala-zdaptb 0 5790: gua-42pym-gly-betapym 5791: phhs-nme35pyr-bala-psdapee 5792: phhs-oxadiaz-bala-betahph 5793: bhs-35fur-bala-zdap 5794: tolhs-25thiaz-bala-psdaptb 5 5795: tolhs-25thiaz-gly-betabph 5796: phhs-24thioph-bala-betaftrif 5797: ibhs-oxadiaz-gly-betamethi 5798: phhs-oxadiaz-bala-ibsdap 5799: ibhs-24thioph-bala-aspbzla 5800: bim-me25thioph-ala-betadcph 5801: bhs-24pym-ala-betameph 5802: phhs-me25oxaz-ala-psdap 5803: tolhs-24thioph-bala-betacthioph 5804: 2py-24thiaz-gly-betadcph 5805: phhs-25thiaz-bala-betadtrif 5806: phhs-me25thioph-leu-zdap 5807: bhs-42nmeim-bala-zdap -183 5808: ibhs-oxadiaz-gly-betadmph 5809: phhs-25oxaz-bala-aspibua 5810: bim-thiadiaz-gly-betapy 5811: tolhs-25methiaz-gly-betadcphch 5 5812: ibhs-nme35pyr-bala-betahcbph 5813: bhs-25methiaz-bala-suabu 5814: tolhs-25oxaz-bala-betadbph 5815: phhs-ithiadiaz-gly-betaoxaz 5816: bhs-nme35pyr-bala-asppha 0 5817: tolhs-24thioph-gly-betahb 5818: bim-me25thioph-ala-psdap 5819: gua-24oxaz-gly-zdap 5820: phhs-25thiaz-gly-betabdimo 5821: phhs-25thiaz-gly-aspaba 5 5822: bhs-53pyrazo-bala-psdap 5823: 2py-42nmeim-leu-zdap 5824: phhs-oxadiaz-gly-betadcphee 5825: imhs-25thiaz-gly-zdap 5826: phhs-25thiaz-bala-aspaba D 5827: phhs-25methiaz-gly-betadhbfu 5828: bhs-24thiaz-bala-beta34meoph 5829: bhs-24thiaz-gly-betahmph 5830: 2py-me25oxaz-bala-betaph 5831: hyd-42nmeim-bala-betadcph 5 5832: bhs-25thiaz-bala-beta3quin 5833: ibhs-ithiadiaz-bala-betabph 5834: ibhs-24thiaz-gly-betapbiph 5835: 2py-25methiaz-bala-betadcph 5836: 2py-25oxaz-leu-psdap 5837: tolhs-oxadiaz-gly-psdapch 5838: bhs-24thioph-ala-zdap 5839: bhs-24thioph-bala-betapych 5840: phhs-25thiaz-bala-betadcph 5841: bgua-42pym-gly-betapy i 5842: bhs-25methiaz-nmgly-betacph 5843: impy-25oxaz-bala-betafbph 5844: phhs-24thiaz-gly-betadcphch -184 5845: phhs-25methiaz-bala-betaimid 5846: ibhs-25methiaz-bala-betahmofu 5847: ibhs-24thiaz-bala-betafbph 5848: ibhs-24thiaz-gly-busu2be 5 5849: 2py-24thioph-hphe-psdap 5850: 2py-me24thiaz-leu-beta34meoph 5851: phhs-24thiaz-gly-betaet 5852: phhs-25thiaz-gly-betameph 5853: ibhs-25methiaz-bala-betathiome 0 5854: tolhs-oxadiaz-bala-betacph 5855: ibhs-nme35pyr-gly-psdaptb 5856: bim-oxadiaz-bala-aspaba 5857: bim-24oxaz-gly-betainyl 5858: bhs-nme35pyr-gly-betaimid 5 5859: ibhs-25thiaz-bala-betahph 5860: 2py-25thiaz-gly-betameph 5861: phhs-24thioph-gly-busu2be 5862: tolhs-25oxaz-gly-betaol 5863: bhs-24thioph-ala-betafphe 0 5864: bhs-25thiaz-nmgly-betadmoph 5865: ibhs-oxadiaz-bala-aspbzla 5866: bhs-ithiadiaz-bala-betacbph 5867: bim-35fur-ala-psdap 5868: tolhs-25thiaz-gly-betathiome 5 5869: tolhs-nme35pyr-gly-betahmofu 5870: ibhs-25methiaz-gly-betaibph 5871: tolhs-25thiaz-bala-betapytb 5872: impy-25oxaz-gly-betaphethio 5873: gua-24oxaz-gly-betabthioph 3 5874: gua-24thiaz-gly-betahcbph 5875: tolhs-nme35pyr-gly-betapym 5876: bim-me24thiaz-leu-betaph 5877: pahs-24thioph-bala-betameph 5878: bim-25thiaz-gly-betahmph 5 5879: bhs-25thiaz-gly-betabediox 5880: bhs-24thiaz-gly-betathiobe 5881: gua-42pym-nmgly-betapy -185 5882: gua-24thiaz-gly-betaipr 5883: tolhs-25thiaz-bala-psdap 5884: gua-24thiaz-gly-busu2be 5885: bhs-24thiaz-ala-betaoxaz 5 5886: tolhs-oxadiaz-bala-betabpy 5887: bhs-24thiaz-gly-betapbiph 5888: bhs-me24oxaz-gly-beta34meoph 5889: bhs-24thioph-bala-betaoxaz 5890: tolhs-ithiadiaz-gly-betahmph 0 5891: phhs-25methiaz-bala-busu2be 5892: bhs-24im-leu-zdap 5893: bhs-24thioph-bala-betabpy 5894: bhs-25methiaz-bala-betabpy 5895: ihhs-25oxaz-bala-betadcphtb 5 5896: bhs-25methiaz-gly-ibsdap 5897: phhs-24thiaz-bala-betathioph 5898: phhs-25methiaz-bala-zdap 5899: ibhs-25oxaz-gly-betaamibe 5900: imhs-24thioph-gly-zdap 0 5901: phhs-oxadiaz-gly-betafluo 5902: 2py-26py-ala-betadcph 5903: 2py-me25thioph-leu-betaph 5904: tolhs-25methiaz-gly-betaoxope 5905: phhs-ithiadiaz-bala-betaol 5 5906: tolhs-24thiaz-gly-betadtrif 5907: bhs-25methiaz-gly-psdapee 5908: bhs-ithiadiaz-gly-beta23meoph 5909: bhs-me24thiaz-gly-zdap 5910: 2pmhs-25methiaz-gly-betafph 0 5911: bhs-25oxaz-bala-betadtrif 5912: bhs-25methiaz-bala-betatos 5913: bim-24thioph-bala-psdap 5914: tolhs-nme35pyr-bala-betafbph 5915: tolhs-24thiaz-bala-aspaba 5 5916: 2py-triaz-gly-betadcph 5917: ibhs-24thiaz-gly-betahph 5918: tolhs-nme35pyr-gly-beta4bph -186 5919: tolhs-ithiadiaz-bala-beta4bph 5920: phhs-25oxaz-gly-betadcph 5921: phhs-25methiaz-bala-betadmoph 5922: phhs-oxadiaz-gly-csdap 5 5923: tolhs-oxadiaz-bala-betadmph 5924: impy-42nmeim-bala-betahbcph 5925: tolhs-24thioph-gly-csdap 5926: ibhs-24thioph-bala-betabmph 5927: bhs-ithiadiaz-bala-betapyr 0 5928: tolhs-25thiaz-gly-betathiobe 5929: bhs-nme35pyr-bala-betabpy 5930: phhs-oxadiaz-gly-betadmph 5931: tolhs-24thiaz-bala-betadcphch 5932: dhim-25thioph-ala-betameph 5 5933: bhs-24thioph-bala-betaomebendi 5934: phhs-25oxaz-bala-betadmph 5935: bim-me24oxaz-leu-betapy 5936: bhs-oxadiaz-gly-betainyl 5937: tolhs-oxadiaz-gly-betaanaphth 0 5938: tolhs-24thioph-bala-betabph 5939: phhs-25thiaz-bala-betambiph 5940: bhs-me25oxaz-bala-zdap 5941: 2pmhs-25oxaz-bala-betaet 5942: phhs-24thioph-gly-betahph 5 5943: bhs-oxadiaz-gly-betadtrif 5944: 2py-oxadiaz-leu-betapy 5945: bhs-nme35pyr-bala-betaheph 5946: bim-25fur-gly-betapy 5947: bhs-25methiaz-gly-betaoxope 5948: tolhs-25oxaz-gly-betatrif 5949: dhthi-25oxaz-gly-zdap 5950: bhs-oxadiaz-nmgly-beta23meoph 5951: tolhs-25oxaz-gly-betaibph 5952: phhs-24thiaz-bala-betaanaphth 5953: bim-24thiaz-bala-betacph 5954: 2py-42nmeim-bala-betadcph 5955: ibhs-25thiaz-gly-psdapee -187 5956: bhs-ithiadiaz-nmgly-beta3quin 5957: tolhs-24thioph-gly-betaheph 5958: bhs-ithiadiaz-ala-beta34meoph 5959: phhs-25oxaz-bala-csdap 5 5960: tolhs-ithiadiaz-gly-betabenfu 5961: ibhs-ithiadiaz-gly-betafu3 5962: bhs-26py-ala-betainyl 5963: bim-me25thioph-ala-zdap 5964: phhs-nme35pyr-bala-aspibua 0 5965: phhs-ithiadiaz-bala-zdap 5966: ibhs-oxadiaz-bala-betadcphee 5967: tolhs-oxadiaz-gly-betathioph 5968: impy-25methiaz-bala-busu2be 5969: bhs-ithiadiaz-bala-suabu 5 5970: bhs-nme35pyr-nmgly-betacthioph 5971: bhs-35fur-bala-psdap 5972: bhs-24thiaz-bala-betaftrif 5973: bhs-25oxaz-gly-betafbph 5974: tolhs-25thiaz-gly-betaibph 0 5975: 2py-me24thiaz-gly-betadcph 5976: 2py-me24oxaz-bala-psdap 5977: bim-ithiadiaz-ala-betadcph 5978: 2py-25thiaz-gly-betaol 5979: phhs-25oxaz-bala-zdapee 5 5980: tolhs-25thiaz-bala-beta23meoph 5981: bhs-25thiaz-gly-betahbcph 5982: ibhs-oxadiaz-gly-betahmofu 5983: ibhs-ithiadiaz-gly-betahbcph 5984: 2py-25thiaz-bala-betahni 5985: tolhs-24thiaz-bala-betaipr 5986: 2py-25thioph-ala-betapy 5987: ibhs-oxadiaz-gly-betabthioph 5988: ibhs-25methiaz-gly-betapym 5989: 2py-24thiaz-bala-betadcph 5990: phhs-me25thioph-leu-betadcph 5991: ibhs-24thioph-gly-betainyl 5992: phhs-24thiaz-bala-betatbuph -188 5993: tolhs-oxadiaz-bala-psdaptb 5994: dhim-24oxaz-ala-betapy 5995: ibhs-25methiaz-bala-betafluo 5996: gua-26py-gly-betahph 5 5997: phhs-25thiaz-bala-psdapee 5998: phhs-24thiaz-gly-betaol 5999: bhs-25methiaz-bala-betaol 6000: 2py-nme35pyr-gly-aspibua 6001: ibhs-25oxaz-gly-beta35dbph 0 6002: tolhs-nme35pyr-gly-betahb 6003: ibhs-nme35pyr-gly-betaheph 6004: bhs-25oxaz-nmgly-betamesu 6005: 2py-24oxaz-ala-betadcph 6006: ibhs-ithiadiaz-gly-betaamibe 5 6007: tolhs-24thioph-gly-betadcphee 6008: tolhs-25thiaz-bala-asppha 6009: bhs-24thioph-bala-betadhbfu 6010: ibhs-ithiadiaz-bala-betadbph 6011: phhs-oxadiaz-gly-betathio3 0 6012: bhs-nme35pyr-nmgly-ibsdap 6013: ibhs-24thiaz-gly-betamethioph 6014: ibhs-oxadiaz-bala-betathio3 6015: 2py-25oxaz-nmgly-betadcph 6016: 2py-42nmeim-gly-betahcbph 5 6017: tolhs-24thioph-gly-betahdbph 6018: ibhs-nme35pyr-gly-betahdbph 6019: ibhs-24thiaz-gly-betabthioph 6020: bhs-25oxaz-bala-betapym 6021: ibhs-25methiaz-bala-betadito 6022: bhs-25thiaz-gly-betapbiph 6023: bhs-ithiadiaz-gly-betaibph 6024: ibhs-24thiaz-gly-betahni 6025: phhs-25oxaz-bala-betameph 6026: 2py-ithiadiaz-gly-aspbzla 5 6027: bhs-25methiaz-gly-betathiome 6028: phhs-ithiadiaz-gly-betahdcph 6029: tolhs-nme35pyr-bala-betaheph -189 6030: tolhs-25thiaz-bala-betabph 6031: phhs-nme35pyr-bala-betatos 6032: phhs-me25thiaz-gly-beta34meoph 6033: tolhs-25methiaz-gly-betatrif 5 6034: tolhs-nme35pyr-gly-betacbph 6035: bim-25oxaz-gly-aspaba 6036: bhs-nme35pyr-bala-betabnaphth 6037: ibhs-24thioph-bala-betainyl 6038: phhs-ithiadiaz-gly-betaibph 0 6039: tolhs-nme35pyr-gly-betaftrif 6040: ur-25thiaz-gly-betainyl 6041: bim-oxadiaz-leu-betadcph 6042: phhs-oxadiaz-gly-betaipr 6043: tolhs-25thiaz-bala-betafphe 5 6044: ciina-24thiaz-gly-betainyl 6045: ibhs-25oxaz-gly-csdap 6046: bhs-25oxaz-bala-betathio3 6047: phhs-me25thioph-gly-betapy 6048: tolhs-me24thiaz-gly-beta34meoph 0 6049: bim-25oxaz-phe-betapy 6050: tolhs-25thiaz-bala-betaphethio 6051: dhim-24thiaz-ala-betainyl 6052: tolhs-oxadiaz-bala-betaet 6053: tolhs-me24thiaz-ala-zdap 5 6054: tolhs-25oxaz-bala-betatos 6055: ibhs-24thiaz-gly-betatrif 6056: tolhs-oxadiaz-gly-betahbcph 6057: ibhs-25oxaz-gly-betaol 6058: 2py-triaz-leu-psdap 6059: phhs-nme35pyr-gly-betahmofu 6060: bhs-ithiadiaz-bala-betafphe 6061: phhs-nme35pyr-gly-busu2be 6062: tolhs-me25thioph-leu-psdap 6063: thazep-42pym-gly-betapy 6064: ibhs-oxadiaz-bala-beta1 3bendi 6065: tolhs-25thiaz-gly-betafu3 6066: ibhs-oxadiaz-gly-betacbph -190 6067: gua-25thiaz-gly-betabpy 6068: phhs-nme35pyr-bala-csdap 6069: bim-53pyrazo-gly-psdap 6070: ibhs-ithiadiaz-bala-betaimid 5 6071: bhs-52thiaz-ala-zdap 6072: ibhs-24thiaz-bala-betaheph 6073: tolhs-25oxaz-gly-betatos 6074: 2py-24oxaz-bala-betadcph 6075: bhs-35thioph-leu-zdap 0 6076: bhs-ithiadiaz-bala-zdapch 6077: bhs-24thioph-nmgly-betaanaphth 6078: tolhs-25methiaz-gly-psdap 6079: bhs-me24oxaz-ala-betapy 6080: ibhs-25methiaz-gly-betadhbfu 5 6081: bhs-25thiaz-bala-ibsdap 6082: tolhs-nme35pyr-gly-betahdbph 6083: 2py-42nmeim-bala-betaibph 6084: phhs-24thiaz-gly-betadbph 6085: phhs-25oxaz-bala-betafphe 0 6086: 2py-26py-gly-zdap 6087: tolhs-oxadiaz-gly-betabthioph 6088: tolhs-25oxaz-bala-betadtrif 6089: bim-me25oxaz-leu-betaph 6090: ibhs-ithiadiaz-bala-beta34meoph 5 6091: phhs-nme35pyr-gly-zdaptb 6092: ibhs-24thiaz-bala-aspibua 6093: tolhs-24thioph-gly-betabpy 6094: bhs-ithiadiaz-gly-betadmoph 6095: gua-24thiaz-gly-betaphethio 0 6096: phhs-oxadiaz-bala-betadtrif 6097: ibhs-24thioph-bala-asppha 6098: phhs-nme35pyr-gly-betacthioph 6099: tolhs-25methiaz-bala-betaanaphth 6100: bhs-ithiadiaz-gly-betadcphch 5 6101: bhs-25methiaz-bala-betahni 6102: bhs-24thiaz-gly-psdapch 6103: bim-42nmeim-leu-betadcph -191 6104: tolhs-24thioph-bala-beta34meoph 6105: tolhs-24thiaz-bala-betafph 6106: tolhs-oxadiaz-gly-betaph 6107: phhs-ithiadiaz-gly-aspaba 5 6108: phhs-25oxaz-bala-ibsdap 6109: ibhs-25thiaz-gly-betabpy 6110: bhs-25methiaz-bala-betabnaphth 6111: tolhs-25oxaz-bala-betambiph 6112: tolhs-me25thioph-gly-beta34meoph 0 6113: tolhs-25oxaz-bala-betathiome 6114: dhim-25thioph-gly-betainyl 6115: ibhs-25oxaz-bala-aspibua 6116: phhs-oxadiaz-gly-suabu 6117: ibhs-nme35pyr-bala-beta35dbph 5 6118: 2py-25methiaz-leu-psdap 6119: bim-thiadiaz-gly-psdap 6120: ibhs-ithiadiaz-gly-betadcphch 6121: tolhs-oxadiaz-bala-betaibph 6122: bhs-ithiadiaz-bala-betafph 0 6123: ibhs-oxadiaz-bala-betahdbph 6124: bhs-25thiaz-bala-betafph 6125: phhs-nme35pyr-gly-betapym 6126: ibhs-25oxaz-bala-betadcph 6127: phhs-25oxaz-bala-betahdbph 5 6128: tolhs-oxadiaz-bala-betadmoph 6129: tolhs-24thioph-gly-betahdcph 6130: bhs-25methiaz-bala-betaph 6131: bhs-25thiaz-gly-betapyee 6132: tolhs-25methiaz-bala-betaimid 0 6133: gua-42pym-gly-betathio3 6134: bhs-25methiaz-nmgly-beta23meoph 6135: sabhs-42nmeim-gly-betapy 6136: bhs-24thiaz-bala-betathioph 6137: impy-25methiaz-bala-betaphethioa 5 6138: bhs-nme35pyr-gly-suabu 6139: tolhs-ithiadiaz-gly-betapy 6140: phhs-oxadiaz-gly-zdaptb -192 6141: phhs-ithiadiaz-gly-betahcbph 6142: tolhs-me24oxaz-ala-psdap 6143: bhs-oxadiaz-gly-betahmph 6144: ibhs-ithiadiaz-bala-betamesu 5 6145: bim-52thiaz-ala-zdap 6146: bhs-24thioph-ala-beta34dcph 6147: ibhs-24thiaz-bala-ibsdap 6148: tolhs-ithiadiaz-bala-betabnaphth 6149: ibhs-oxadiaz-gly-betadcphtb 0 6150: tolhs-oxadiaz-bala-betafphe 6151: tolhs-nme35pyr-gly-betapytb 6152: bhs-53pyrazo-ala-betadcph 6153: 2py-26py-nmala-zdap 6154: bhs-25oxaz-gly-betaheph 5 6155: bhs-25thiaz-gly-betapym 6156: bhs-24thiaz-leu-betapy 6157: phhs-oxadiaz-bala-betadhbfu 6158: phhs-oxadiaz-bala-asppha 6159: bhs-25thioph-gly-betainyl 3 6160: tolhs-oxadiaz-gly-zdap 6161: impy-25thiaz-ala-betapy 6162: tolhs-25methiaz-gly-busu2be 6163: 2py-35thioph-leu-psdap 6164: phhs-25methiaz-bala-betabpy 5 6165: 2py-26py-gly-betabnaphth 6166: bhs-25methiaz-bala-betahbcph 6167: ibhs-24thioph-gly-betaipr 6168: bhs-oxadiaz-bala-betaimid 6169: impy-25oxaz-bala-betabdimo 6170: gua-24thiaz-gly-betapbiph 6171: tolhs-24thioph-gly-betal 3bendi 6172: bhs-24thioph-bala-betabph 6173: bhs-24thiaz-bala-betaimid 6174: ibhs-24thioph-gly-betadhbfu 6175: tolhs-24thiaz-gly-betabediox 6176: phhs-25oxaz-gly-betatrif 6177: bhs-triaz-gly-zdap -193 6178: bhs-25thiaz-gly-beta4bph 6179: tolhs-25thiaz-bala-betabenfu 6180: bhs-24thiaz-gly-betaheph 6181: bhs-nme35pyr-leu-zdap 5 6182: impy-42nmeim-bala-betabpy 6183: bhs-25methiaz-bala-aspibua 6184: tolhs-25thiaz-gly-betainyl 6185: tolhs-me24thioph-leu-betaph 6186: 2py-ithiadiaz-gly-zdap 0 6187: impy-25oxaz-gly-betafu2 6188: tolhs-me25oxaz-gly-beta34meoph 6189: thpy-24thiaz-gly-betadcph 6190: 2py-25oxaz-gly-aspaba 6191: tolhs-24thiaz-bala-zdap 5 6192: thpym-2thioph-gly-zdap 6193: phhs-25thiaz-bala-betahcbph 6194: ibhs-25methiaz-gly-betapyr 6195: bhs-ithiadiaz-bala-betaimid 6196: 2py-me25thiaz-bala-betadcph 0 6197: bhs-25thiaz-gly-betafbph 6198: phhs-24thiaz-gly-betahcbph 6199: phhs-25thiaz-gly-betabmph 6200: bhs-25oxaz-gly-betabenfu 6201: bhs-ithiadiaz-bala-betaanaphth 5 6202: bim-me24thioph-gly-betapy 6203: bhs-24thioph-ala-beta3quin 6204: tolhs-25oxaz-bala-betahdbph 6205: bhs-oxadiaz-gly-psdap 6206: bhs-25oxaz-bala-betatos 6207: ibhs-oxadiaz-bala-betapyr 6208: tolhs-me24thiaz-bala-beta34meoph 6209: 2pmhs-25methiaz-gly-betameph 6210: phhs-25oxaz-gly-betah35dc 6211: hyd-42pym-gly-psdap i 6212: ibhs-ithiadiaz-gly-betaet 6213: 2py-me24thioph-gly-betapy 6214: phhs-24thiaz-gly-betahbcph -194 6215: phhs-oxadiaz-bala-zdap 6216: phhs-ithiadiaz-bala-betapyr 6217: phhs-24thioph-gly-asppha 6218: bhs-24thioph-bala-betaanaphth 5 6219: bhs-24thiaz-bala-betahbcph 6220: 2py-25methiaz-bala-zdap 6221: bhs-ithiadiaz-gly-betadbph 6222: 2pmhs-25methiaz-gly-betahbcph 6223: bhs-ithiadiaz-gly-betabpy 0 6224: bim-25thiaz-bala-betafphe 6225: phhs-24thiaz-bala-betahbcph 6226: ibhs-24thiaz-bala-betaimid 6227: bhs-25thiaz-bala-betadtrif 6228: bhs-35fur-ala-zdap 5 6229: bhs-ithiadiaz-bala-aspaba 6230: bhs-24thiaz-bala-betapytb 6231: tolhs-25oxaz-bala-beta23meoph 6232: bim-24thioph-bala-betafphe 6233: ibhs-24thioph-bala-betadcphtb !0 6234: bim-triaz-leu-zdap 6235: tolhs-25methiaz-bala-aspaba 6236: bhs-25oxaz-gly-zdapee 6237: bhs-nme35pyr-bala-betadhbfu 6238: ibhs-25oxaz-gly-betainyl !5 6239: phhs-me24thiaz-leu-betapy 6240: phhs-nme35pyr-bala-betatrif 6241: bhs-nme35pyr-gly-betapych 6242: bim-nme35pyr-gly-psdap 6243: phhs-ithiadiaz-gly-zdapch 0 6244: bhs-42oxaz-gly-psdap 6245: bhs-me24thiaz-ala-psdap 6246: tolhs-25methiaz-bala-betaet 6247: bhs-me24oxaz-bala-betadcph 6248: phhs-25methiaz-bala-betaoxope 15 6249: bhs-oxadiaz-gly-betabthioph 6250: tolhs-25methiaz-gly-betahdbph 6251: phhs-oxadiaz-gly-betabph -195 6252: ibhs-ithiadiaz-gly-betaphethioa 6253: tolhs-25oxaz-bala-beta35dbph 6254: tolhs-24thiaz-gly-betadbph 6255: ibhs-25oxaz-gly-betafbph 5 6256: impy-25thiaz-bala-betainyl 6257: 2py-24thioph-gly-zdap 6258: phhs-oxadiaz-gly-psdaptb 6259: dhthi-25thiaz-bala-betadcph 6260: ibhs-24thiaz-gly-betafu3 0 6261: phhs-me24oxaz-ala-betadcph 6262: bhs-ithiadiaz-bala-betadtrif 6263: bhs-ithiadiaz-nmgly-beta34meoph 6264: bhs-24thiaz-gly-betapytb 6265: 2py-24thioph-ala-psdap 5 6266: nmhs-26py-gly-betapy 6267: bim-26py-ala-psdap 6268: gua-26py-gly-betamesu 6269: 2py-oxadiaz-bala-aspbzla 6270: phhs-24thioph-bala-betadcphch 3 6271: gua-42pym-gly-betacbph 6272: bhs-24thiaz-bala-betabpy 6273: phhs-ithiadiaz-bala-betainyl 6274: phhs-ithiadiaz-gly-betadcphch 6275: phhs-25thiaz-bala-betahph 5 6276: ibhs-25methiaz-bala-betapyee 6277: ibhs-24thiaz-gly-aspbzla 6278: phhs-24thiaz-bala-betaoxope 6279: ibhs-24thioph-bala-betaphethioa 6280: tolhs-ithiadiaz-gly-betamethi 6281: bim-24thiaz-gly-betainyl 6282: phhs-25oxaz-bala-betapym 6283: tolhs-me24oxaz-bala-zdap 6284: bhs-25thioph-bala-betapy 6285: tolhs-24thioph-bala-betaimid 5 6286: bim-25thiaz-gly-aspbzla 6287: tolhs-ithiadiaz-gly-betadtrif 6288: ibhs-24thiaz-bala-betaftrif -196 6289: 2py-thiadiaz-bala-psdap 6290: phhs-25oxaz-bala-betabmph 6291: phhs-nme35pyr-gly-betahmph 6292: 2py-53pyrazo-gly-betadcph 5 6293: bhs-me24thiaz-leu-psdap 6294: bim-24im-gly-betadcph 6295: 2py-24oxaz-ala-betameph 6296: tolhs-24thiaz-gly-betahbcph 6297: phhs-25methiaz-bala-beta35dbph 0 6298: phhs-25thiaz-gly-betapyr 6299: ibhs-25thiaz-bala-betadbph 6300: bhs-nme35pyr-bala-betaet 6301: bim-me25thiaz-gly-zdap 6302: phhs-25thiaz-bala-betaanaphth 5 6303: bhs-nme35pyr-gly-betaol 6304: phhs-24thioph-bala-betadtrif 6305: phhs-me25thiaz-leu-beta34meoph 6306: ibhs-25thiaz-gly-betamethi 6307: bim-24thioph-leu-zdap 0 6308: bhs-ithiadiaz-bala-betathio3 6309: 2pmhs-24thiaz-gly-betabpy 6310: bhs-24thiaz-gly-betapym 6311: phhs-25methiaz-gly-betampy 6312: bim-25oxaz-bala-asppha 5 6313: impy-42nmeim-gly-betamethioph 6314: tolhs-nme35pyr-bala-betahcbph 6315: bhs-oxadiaz-bala-betabnaphth 6316: bhs-nme35pyr-gly-betaipr 6317: ibhs-24thiaz-bala-betahc 6318: tolhs-25methiaz-gly-betaanaphth 6319: 2py-me25thioph-bala-betaph 6320: tolhs-24thioph-gly-betapych 6321: ibhs-oxadiaz-gly-betabenfu 6322: phhs-25thiaz-gly-betamesu 6323: tolhs-me24thioph-bala-betaph 6324: dimethpym-26py-gly-betahdcph 6325: ibhs-25thiaz-gly-beta34meoph -197 6326: bim-me25thiaz-gly-betapy 6327: phhs-24thioph-gly-betapym 6328: 2py-me25thiaz-ala-beta34meoph 6329: phhs-oxadiaz-bala-betadbph 5 6330: ibhs-nme35pyr-bala-betafbph 6331: ibhs-25thiaz-bala-betatrif 6332: tolhs-oxadiaz-gly-betaipr 6333: bim-me25thiaz-bala-betapy 6334: bhs-25oxaz-gly-betahc 0 6335: ibhs-24thioph-bala-betadtrif 6336: bhs-nme35pyr-gly-betahmo 6337: 2py-52thiaz-gly-betadcph 6338: bhs-35fur-leu-betadcph 6339: dhim-26py-gly-betainyl 5 6340: bim-me24thiaz-ala-zdap 6341: ibhs-nme35pyr-gly-betamesu 6342: ibhs-oxadiaz-bala-aspibua 6343: tolhs-24thiaz-bala-psdapee 6344: bim-me24oxaz-bala-psdap 0 6345: bhs-me24thioph-gly-psdap 6346: bhs-24thioph-gly-betaet 6347: ibhs-ithiadiaz-bala-beta23meoph 6348: 2py-25thiaz-bala-suabu 6349: bhs-me24thiaz-bala-betadcph 5 6350: 2py-25thiaz-bala-betaet 6351: bhs-oxadiaz-gly-asppha 6352: ibhs-24thioph-bala-betal 3bendi 6353: phhs-25methiaz-bala-betabnaphth 6354: 2py-25thiaz-gly-betacthioph 0 6355: dhim-25oxaz-bala-betadcph 6356: phhs-me24thioph-bala-psdap 6357: 2py-ithiadiaz-bala-aspibua 6358: phhs-24thioph-gly-betadmoph 6359: bhs-ithiadiaz-bala-betadcphch 5 6360: ibhs-24thiaz-bala-betadmoph 6361: phhs-24thioph-bala-beta4bph 6362: ibhs-25oxaz-bala-betapych -198 6363: ibhs-24thioph-bala-betabph 6364: bhs-25oxaz-ala-betapy 6365: bim-25fur-leu-betapy 6366: ibhs-24thioph-bala-beta35dbph 5 6367: bhs-24thioph-bala-betaftrif 6368: bhs-25fur-ala-zdap 6369: bhs-25thiaz-bala-beta34meoph 6370: thazep-26py-gly-betapy 6371: bhs-nme35pyr-gly-betathio3 0 6372: 2pmhs-25oxaz-bala-betaoxope 6373: tolhs-oxadiaz-gly-betacph 6374: phhs-25methiaz-bala-psdaptb 6375: bim-25thiaz-nmala-betadcph 6376: bim-25thiaz-bala-aspbzla 5 6377: bhs-24thiaz-nmgly-betafphe 6378: tolhs-ithiadiaz-gly-betaph 6379: ibhs-ithiadiaz-bala-betaol 6380: impy-24thioph-gly-betathiobe 6381: tolhs-25methiaz-gly-betacthioph 0 6382: ibhs-24thiaz-bala-betameph 6383: 2py-25methiaz-bala-betaet 6384: bhs-25oxaz-nmgly-beta34meoph 6385: gua-24thiaz-gly-betapy 6386: tolhs-25oxaz-bala-betahcbph 5 6387: bhs-42nmeim-bala-betacthioph 6388: tolhs-25methiaz-gly-betameph 6389: ibhs-25thiaz-bala-betathiome 6390: bhs-nme35pyr-bala-betathio3 6391: phhs-oxadiaz-bala-betahmofu 0 6392: ibhs-ithiadiaz-bala-betadmoph 6393: tolhs-24thiaz-gly-aspaba 6394: impy-25thiaz-bala-betamesu 6395: ibhs-24thiaz-gly-betaibph 6396: bhs-25oxaz-bala-betainyl 5 6397: bhs-25methiaz-bala-betahph 6398: gua-25thiaz-nmgly-betapy 6399: bhs-24thioph-gly-aspbzla -199 6400: bhs-25oxaz-nmgly-ibsdap 6401: 2py-24im-leu-zdap 6402: phhs-nme35pyr-bala-betafbph 6403: tolhs-25oxaz-bala-zdap 5 6404: phhs-oxadiaz-gly-betahmofu 6405: bim-42nmeim-bala-betathiobe 6406: bhs-25oxaz-bala-zdaptb 6407: ibhs-25thiaz-gly-aspbzla 6408: bim-24oxaz-bala-betapy 0 6409: ibhs-25oxaz-gly-betal 3bendi 6410: bhs-24thiaz-gly-betahbcph 6411: ibhs-25methiaz-bala-betapbiph 6412: tolhs-ithiadiaz-bala-betadito 6413: phhs-ithiadiaz-bala-betatrif 5 6414: tolhs-24thiaz-gly-betadcphch 6415: bim-25methiaz-bala-betacph 6416: phhs-25methiaz-gly-betamethioph 6417: tolhs-25methiaz-gly-betapyr 6418: bhs-ithiadiaz-gly-psdaptb 0 6419: ibhs-ithiadiaz-bala-betapyr 6420: phhs-24thioph-bala-betahdbph 6421: dlhim-42pym-ala-betapy 6422: bhs-25thiaz-ala-betambiph 6423: 2py-24thioph-gly-asppha 5 6424: phhs-24thiaz-bala-betafph 6425: 2py-24thiaz-bala-betaet 6426: tolhs-ithiadiaz-bala-betahph 6427: 2py-nme35pyr-ala-betadcph 6428: phhs-me24thioph-bala-betaph 6429: bhs-25oxaz-gly-betaoxope 6430: phhs-24thiaz-gly-betaimid 6431: tolhs-25methiaz-gly-betafphe 6432: bhs-35thioph-leu-betapy 6433: ibhs-25thiaz-bala-betadcphch 5 6434: tolhs-25thiaz-bala-betatbuph 6435: bhs-24im-gly-betadcph 6436: 2py-26py-gly-betameph -200 6437: hs-25thioph-gly-zdap 6438: phhs-me24oxaz-gly-zdap 6439: tolhs-25oxaz-bala-betadhbf u 6440: bhs-24thioph-bala-betabdimo 5 6441: ibhs-ithiadiaz-bala-betahdbph 6442: phhs-24thioph-bala-betapym 6443: phhs-25methiaz-gly-betadcphee 6444: bhs-25methiaz-gly-betahph 6445: phhs-24thiaz-bala-betaheph 0 6446: bhs-25oxaz-gly-betaoxaz 6447: bhs-24thiaz-bala-aspibua 6448: phhs-ithiadiaz-gly-betabthioph 6449: agua-26py-gly-betainyl 6450: phhs-24thioph-gly-betahmofu 5 6451: bhs-oxadiaz-bala-betatrif 6452: bhs-me24thioph-ala-betaph 6453: tolhs-25methiaz-gly-betabediox 6454: tolhs-24thioph-bala-betabediox 6455: bhs-24thioph-gly-betambiph 0 6456: bim-35fur-leu-betapy 6457: phhs-24thiaz-gly-csdap 6458: agua-42nmeim-gly-betapy 6459: tolhs-me24thioph-ala-psdap 6460: tolhs-ithiadiaz-bala-betabdimo 5 6461: tolhs-me25oxaz-gly-betaph 6462: 2py-oxadiaz-gly-asppha 6463: tolhs-25thiaz-gly-betahph 6464: bhs-nme35pyr-gly-betahdbph 6465: bhs-24thiaz-gly-ibsdap 0 6466: phhs-nme35pyr-gly-beta4bph 6467: bhs-25oxaz-bala-betathiome 6468: tolhs-25thiaz-bala-betaamibe 6469: tolhs-25oxaz-bala-zdapee 6470: impy-25thiaz-bala-betaftrif 35 6471: tolhs-25oxaz-gly-betadcphtb 6472: bhs-me24thioph-bala-psdap 6473: bhs-nme35pyr-nmgly-betathio3 -201 6474: bhs-oxadiaz-gly-betapym 6475: phhs-24thioph-gly-betadito 6476: ibhs-25oxaz-bala-betapbiph 6477: tolhs-nme35pyr-bala-betatrif 5 6478: bhs-25methiaz-bala-beta34dcph 6479: bim-25methiaz-gly-betadmph 6480: phhs-25methiaz-gly-betahc 6481: tolhs-24thiaz-bala-betah35dc 6482: bhs-me25thioph-ala-betaph ) 6483: tolhs-oxadiaz-gly-betahmph 6484: tolhs-25thiaz-bala-betatos 6485: tolhs-ithiadiaz-gly-betaol 6486: tolhs-24thioph-bala-betadmoph 6487: tolhs-oxadiaz-gly-betainyl 5 6488: phhs-25methiaz-bala-beta4bph 6489: bim-thiadiaz-ala-betadcph 6490: ur-25methiaz-gly-betadcph 6491: bim-42nmeim-nmgly-zdap 6492: tolhs-24thiaz-bala-betaph 6493: ibhs-24thioph-gly-betapyee 6494: thazep-24oxaz-gly-betainyl 6495: 4pmhs-25thiaz-bala-betameph 6496: ibhs-25methiaz-gly-suabu 6497: tolhs-25thiaz-bala-betapym 6498: bhs-oxadiaz-gly-beta23meoph 6499: tolhs-nme35pyr-gly-psdap 6500: 2pmhs-42nmeim-gly-betahmo 6501: phhs-ithiadiaz-bala-betaomebendi 6502: bhs-me24thiaz-ala-beta34meoph 6503: bhs-24thiaz-bala-beta3quin 6504: phhs-25methiaz-gly-betathioph 6505: tolhs-me25oxaz-gly-betapy 6506: phhs-24thioph-gly-betapyr 6507: tolhs-25oxaz-bala-betapym 6508: bhs-ithiadiaz-gly-betaph 6509: bim-25oxaz-leu-psdap 6510: impy-24thioph-bala-betaftrif -202 6511: phhs-24thioph-gly-betah35dc 6512: ibhs-24thiaz-gly-betadmoph 6513: bhs-42oxaz-ala-betapy 6514: thazep-42nmeim-bala-betameph 5 6515: bhs-24thiaz-bala-busu2be 6516: gua-25thiaz-gly-betahph 6517: gua-24thiaz-gly-betainyl 6518: bhs-25thiaz-gly-betahmofu 6519: phhs-nme35pyr-gly-betahmo 3 6520: bhs-25thiaz-gly-betaamibe 6521: phhs-24thioph-gly-betapy 6522: bhs-oxadiaz-gly-betadmph 6523: tolhs-me24oxaz-ala-betadcph 6524: thazep-25methiaz-bala-zdap 5 6525: tolhs-ithiadiaz-bala-aspibua 6526: phhs-me25oxaz-bala-zdap 6527: phhs-nme35pyr-gly-betadito 6528: 2py-24oxaz-bala-psdap 6529: bhs-25methiaz-bala-beta35dbph 6530: phhs-24thioph-bala-zdaptb 6531: bhs-35fur-gly-betadcph 6532: phhs-25thiaz-gly-beta34meoph 6533: phhs-25thiaz-gly-betaphethio 6534: agua-24oxaz-gly-betainyl 6535: phhs-25oxaz-bala-betahc 6536: 2py-53pyrazo-leu-zdap 6537: ibhs-25methiaz-bala-aspibua 6538: 2py-24thiaz-gly-betapy 6539: tolhs-ithiadiaz-gly-betaphethio 6540: ibhs-oxadiaz-bala-betaipr 6541: bhs-25thiaz-gly-betathio3 6542: gua-24oxaz-gly-betacbph 6543: bhs-24oxaz-gly-betapy 6544: tolhs-24thioph-bala-betafu2 6545: phhs-24thioph-gly-betamethi 6546: bhs-nme35pyr-bala-beta34dcph 6547: phhs-oxadiaz-bala-betaheph -203 6548: 2py-oxadiaz-gly-betapy 6549: bhs-25methiaz-nmgly-betameph 6550: 2py-me24oxaz-ala-betadcph 6551: bim-triaz-ala-psdap 5 6552: ibhs-25thiaz-gly-betabenfu 6553: bim-42nmeim-bala-betapy 6554: bhs-25thiaz-gly-betabnaphth 6555: bhs-ithiadiaz-bala-betadhbfu 6556: tolhs-25thiaz-gly-betaipro 0 6557: dhpyrr-26py-gly-psdap 6558: bhs-24thiaz-ala-betadcph 6559: hs-25thiaz-gly-betainyl 6560: bhs-25oxaz-gly-betamethi 6561: bhs-nme35pyr-bala-beta34meoph 5 6562: ibhs-25methiaz-bala-betaomebendi 6563: phhs-24thioph-gly-betadcphtb 6564: ibhs-25thiaz-gly-betatbuph 6565: ibhs-oxadiaz-gly-betafluo 6566: 2pmhs-24thiaz-phe-zdap D 6567: ibhs-24thioph-gly-betabph 6568: 2py-42nmeim-gly-betaimid 6569: ibhs-25methiaz-gly-betahni 6570: phhs-25methiaz-bala-psdapch 6571: phhs-25oxaz-gly-betabpy 5 6572: bhs-24thiaz-nmgly-beta1 3bendi 6573: ibhs-oxadiaz-gly-betabediox 6574: ibhs-nme35pyr-gly-betacph 6575: bim-24im-leu-psdap 6576: bim-25thiaz-gly-betaomebendi 6577: tolhs-oxadiaz-gly-zdapee 6578: ibhs-24thioph-gly-betahcbph 6579: ibhs-25methiaz-bala-betainyl 6580: ibhs-ithiadiaz-bala-zdapee 6581: tolhs-ithiadiaz-bala-betahc i 6582: tolhs-24thioph-gly-betamesu 6583: tolhs-24thiaz-bala-suabu 6584: bhs-24im-ala-betadcph -204 6585: gua-24thiaz-gly-beta4bph 6586: bhs-25thiaz-bala-betaipr 6587: ibhs-25oxaz-gly-betabnaphth 6588: ibhs-nme35pyr-gly-betadito 5 6589: bim-me25thiaz-ala-zdap 6590: bhs-24thioph-bala-zdapee 6591: ibhs-oxadiaz-gly-betafu2 6592: 2py-me25thiaz-leu-betapy 6593: phhs-24thiaz-bala-betaipr 0 6594: tolhs-ithiadiaz-bala-betafluo 6595: ibhs-24thioph-bala-betaamibe 6596: 2py-25thioph-gly-betapy 6597: bhs-25oxaz-leu-betapy 6598: tolhs-ithiadiaz-gly-betaamibe 5 6599: bhs-me24oxaz-leu-betadcph 6600: bhs-nme35pyr-bala-betafluo 6601: bhs-24thiaz-ala-betabpy 6602: ibhs-25methiaz-bala-betaipr 6603: bhs-24thiaz-bala-betadhbfu D 6604: tolhs-25thiaz-gly-betal 3bendi 6605: phhs-nme35pyr-gly-betadcphee 6606: bhs-25oxaz-gly-betabmph 6607: phhs-25methiaz-gly-betaipr 6608: tolhs-25oxaz-gly-betaftrif 5 6609: bhs-25oxaz-bala-betaphethioa 6610: ibhs-24thioph-gly-betaheph 6611: bhs-24thioph-gly-suabu 6612: tolhs-25methiaz-bala-betamethioph 6613: tolhs-24thioph-gly-asppha 6614: ibhs-25methiaz-bala-betaol 6615: phhs-24thiaz-bala-betapytb 6616: 2pmhs-42nmeim-bala-betafu2 6617: tolhs-oxadiaz-gly-aspibua 6618: bhs-oxadiaz-nmgly-ibsdap i 6619: tolhs-24thioph-gly-betapym 6620: ibhs-nme35pyr-bala-betahmofu 6621: bhs-35thioph-bala-zdap -205 6622: 2pmhs-25methiaz-gly-betahb 6623: gua-26py-gly-betah35dc 6624: phhs-24thiaz-gly-betapytb 6625: bim-42nmeim-gly-betaphethioa 5 6626: 2py-triaz-gly-zdap 6627: bhs-24thiaz-gly-zdap 6628: bhs-24thiaz-bala-betampy 6629: bim-25oxaz-gly-asppha 6630: tolhs-ithiadiaz-bala-beta35dbph 0 6631: phhs-nme35pyr-bala-asppha 6632: ibhs-oxadiaz-gly-betadhbfu 6633: ibhs-ithiadiaz-bala-betadcphch 6634: 2py-ithiadiaz-gly-aspaba 6635: bhs-25oxaz-nmgly-beta3quin 5 6636: ibhs-25oxaz-bala-zdapee 6637: bhs-25oxaz-gly-betabthioph 6638: bhs-oxadiaz-gly-betabph 6639: phhs-oxadiaz-bala-betameph 6640: tolhs-me25thioph-bala-betapy ) 6641: tolhs-ithiadiaz-gly-betahdbph 6642: bim-24thiaz-gly-betadcph 6643: ibhs-nme35pyr-gly-betaphethioa 6644: tolhs-25thiaz-gly-betathio3 6645: phhs-24thioph-bala-betapych 6646: 2py-35fur-leu-betapy 6647: bhs-24chin-gly-zdap 6648: tolhs-oxadiaz-gly-betaamibe 6649: bhs-24thioph-nmgly-betahph 6650: ibhs-oxadiaz-gly-betabdimo 6651: 2py-me24oxaz-gly-beta34meoph 6652: bhs-25thiaz-gly-betaimid 6653: bim-24thiaz-ala-betadcph 6654: tolhs-25oxaz-gly-zdap 6655: bhs-ithiadiaz-gly-betacbph 6656: tolhs-nme35pyr-gly-betal 3bendi 6657: 2py-thiadiaz-bala-betapy 6658: dhim-24oxaz-gly-psdap -206 6659: bhs-nme35pyr-bala-psdap 6660: tolhs-oxadiaz-bala-psdapee 6661: gua-25thiaz-gly-betadmoph 6662: bhs-me24thioph-ala-betadcph 5 6663: bhs-25methiaz-gly-betapbiph 6664: bhs-25oxaz-bala-betadcphch 6665: ibhs-ithiadiaz-bala-betadmph 6666: bim-23thioph-gly-zdap 6667: phhs-24thiaz-bala-betahb 0 6668: tolhs-25methiaz-gly-betapy 6669: bhs-24thioph-met-betadcph 6670: tolhs-24thioph-bala-betapych 6671: 2py-25thioph-leu-betapy 6672: ibhs-25oxaz-bala-asppha 5 6673: phhs-me24oxaz-bala-zdap 6674: ibhs-25oxaz-bala-betabnaphth 6675: tolhs-24thioph-gly-betapbiph 6676: bhs-ithiadiaz-leu-betapy 6677: bhs-25oxaz-bala-zdap D 6678: phhs-25methiaz-gly-betahcbph 6679: tolhs-24thiaz-bala-betahmph 6680: tolhs-nme35pyr-gly-betabpy 6681: ibhs-25methiaz-gly-betaphethio 6682: tolhs-oxadiaz-bala-betahc 5 6683: phhs-25oxaz-bala-zdaptb 6684: ibhs-nme35pyr-bala-betabnaphth 6685: ibhs-25methiaz-gly-aspbzla 6686: tolhs-24thiaz-bala-betafluo 6687: bhs-ithiadiaz-nmgly-betacph 6688: tolhs-25oxaz-bala-betaipro 6689: bim-25thioph-leu-betapy 6690: ibhs-oxadiaz-bala-betathiobe 6691: gua-24thiaz-gly-betathiome 6692: bhs-25thioph-ala-betadcph 6693: 2py-24oxaz-ala-betapy 6694: phhs-25methiaz-bala-betahcbph 6695: ibhs-25thiaz-bala-betathioph -207 6696: ibhs-25oxaz-bala-betapytb 6697: phhs-25thiaz-gly-suabu 6698: phhs-me25thioph-bala-zdap 6699: phhs-oxadiaz-gly-betahmo 5 6700: bhs-25thiaz-gly-betabpy 6701: phhs-24thiaz-bala-betainyl 6702: phhs-24thiaz-bala-betaph 6703: bhs-25methiaz-nmgly-betainyl 6704: bhs-nme35pyr-gly-betabpy 0 6705: bhs-25methiaz-bala-betadtrif 6706: phhs-24thiaz-bala-betafluo 6707: 2py-25thiaz-bala-zdap 6708: 2py-25oxaz-bala-asppha 6709: tolhs-25methiaz-bala-betafu2 5 6710: bhs-25thiaz-bala-beta34dcph 6711: 2py-25oxaz-ala-betadcph 6712: bhs-25methiaz-bala-zdap 6713: phhs-oxadiaz-gly-betamethi 6714: phhs-ithiadiaz-bala-betamesu 0 6715: bhs-24thiaz-bala-betamethioph 6716: bhs-25oxaz-gly-betapym 6717: bhs-ithiadiaz-ala-betainyl 6718: phhs-24thioph-gly-betabmph 6719: ibhs-25methiaz-gly-betadmph 5 6720: ibhs-24thiaz-bala-betahmo 6721: tolhs-24thiaz-gly-beta34dcph 6722: phhs-25methiaz-gly-betaphethioa 6723: 2py-me25oxaz-leu-betaph 6724: phhs-ithiadiaz-bala-betathioph 0 6725: bhs-me25thiaz-leu-betadcph 6726: bhs-25oxaz-bala-betaol 6727: bhs-24thiaz-nmgly-betaanaphth 6728: ibhs-24thioph-bala-betamethioph 6729: phhs-25methiaz-bala-betamethi 5 6730: ibhs-nme35pyr-gly-zdapee 6731: bhs-24thioph-bala-betal 3bendi 6732: ibhs-25oxaz-bala-psdapch -208 6733: ibhs-ithiadiaz-gly-betaoxope 6734: tolhs-25thiaz-gly-betaol 6735: tolhs-nme35pyr-gly-betadtrif 6736: bhs-26py-ala-betadcph 5 6737: tolhs-25thiaz-gly-betadcphtb 6738: impy-25methiaz-gly-betabediox 6739: bhs-25thioph-ala-betapy 6740: phhs-25thiaz-gly-betadito 6741: phhs-oxadiaz-gly-beta34dcph 0 6742: bim-25oxaz-gly-betabpy 6743: ibhs-25methiaz-bala-betadcph 6744: tolhs-25methiaz-bala-ibsdap 6745: phhs-oxadiaz-gly-betaftrif 6746: tolhs-oxadiaz-gly-betaoxaz 5 6747: 2py-thiadiaz-leu-zdap 6748: tolhs-me24thioph-leu-zdap 6749: ibhs-oxadiaz-bala-betaoxope 6750: bhs-ithiadiaz-gly-betaanaphth 6751: thazep-24thiaz-gly-betainyl 0 6752: tolhs-ithiadiaz-gly-betaipr 6753: bhs-35thioph-ala-psdap 6754: bhs-24thioph-bala-betapytb 6755: bhs-me25thiaz-ala-betapy 6756: bhs-25oxaz-gly-betaipro 5 6757: ibhs-25methiaz-bala-betahbcph 6758: bim-52thiaz-gly-betainyl 6759: ibhs-24thioph-bala-betafph 6760: 2py-25thioph-leu-zdap 6761: ibhs-25oxaz-bala-betaet 0 6762: bhs-me25thiaz-leu-betapy 6763: ibhs-25oxaz-gly-betabediox 6764: ibhs-nme35pyr-bala-betabpy 6765: phhs-24thioph-bala-betafph 6766: tolhs-25methiaz-gly-betah35dc 5 6767: tolhs-25oxaz-bala-aspibua 6768: 2py-oxadiaz-gly-zdap 6769: bhs-ithiadiaz-leu-psdap -209 6770: 2py-24oxaz-gly-psdap 6771: bhs-46pym-gly-betameph 6772: tolhs-ithiadiaz-bala-zdapch 6773: ibhs-25oxaz-gly-betathiome 5 6774: bhs-25oxaz-nmgly-betadmoph 6775: tolhs-25oxaz-bala-betahbcph 6776: ibhs-25oxaz-bala-betaphethio 6777: phhs-nme35pyr-bala-betadhbfu 6778: bhs-me24thioph-ala-zdap D 6779: bhs-triaz-leu-psdap 6780: ibhs-24thioph-bala-aspibua 6781: bhs-24py-gly-betapy 6782: gua-25thiaz-gly-beta4bph 6783: ibhs-oxadiaz-bala-betabdimo 5 6784: gua-24thiaz-gly-betambiph 6785: bhs-nme35pyr-ala-beta23meoph 6786: bhs-24thioph-bala-betatbuph 6787: bhs-nme35pyr-bala-zdap 6788: ibhs-24thioph-bala-betafphe ) 6789: phhs-24thiaz-bala-aspbzla 6790: ibhs-ithiadiaz-gly-aspbzla 6791: bhs-24thiaz-bala-betaol 6792: bhs-25methiaz-gly-betadtrif 6793: ibhs-25methiaz-bala-betaanaphth 5 6794: tolhs-25oxaz-gly-betamethi 6795: phhs-oxadiaz-bala-betahb 6796: 2py-me25thiaz-bala-zdap 6797: bhs-24thiaz-gly-betainyl 6798: impy-25thiaz-bala-busu2be 6799: bhs-24thioph-gly-betadbph 6800: ibhs-oxadiaz-gly-aspibua 6801: 2py-25fur-leu-zdap 6802: ibhs-25thiaz-gly-betafbph 6803: tolhs-ithiadiaz-bala-betabediox i 6804: impy-24thioph-bala-betafu3 6805: phhs-25methiaz-gly-beta35dbph 6806: tolhs-me24thioph-bala-beta34meoph -210 6807: bhs-oxadiaz-bala-betafphe 6808: tolhs-oxadiaz-bala-betafu2 6809: cima-25thiaz-gly-betainyl 6810: bhs-25oxaz-bala-betahph 5 6811: ibhs-25oxaz-bala-betatos 6812: ibhs-25thiaz-bala-betacbph 6813: gua-42pym-gly-betaol 6814: tolhs-ithiadiaz-bala-psdap 6815: 2py-26py-gly-betainyl 0 6816: bhs-24thioph-gly-betadhbfu 6817: tolhs-ithiadiaz-bala-betabph 6818: tolhs-24thioph-bala-betaheph 6819: phhs-25thiaz-gly-betabnaphth 6820: tolhs-25thiaz-bala-betathiobe 5 6821: bhs-oxadiaz-ala-beta34dcph 6822: phhs-me24oxaz-leu-betaph 6823: bhs-24thiaz-nmgly-betadito 6824: phhs-oxadiaz-gly-betahni 6825: 2py-25oxaz-bala-betamesu 0 6826: ibhs-nme35pyr-bala-betathiobe 6827: bhs-24thioph-gly-betaheph 6828: phhs-24thiaz-gly-zdapee 6829: ibhs-nme35pyr-gly-betadcphch 6830: tolhs-24thiaz-gly-betatos 5 6831: tolhs-ithiadiaz-bala-betahmo 6832: bhs-me24thiaz-gly-betameph 6833: dhim-me25thiaz-ala-betameph 6834: ibhs-24thiaz-bala-betampy 6835: ibhs-25oxaz-bala-psdaptb 6836: tolhs-25thiaz-bala-betampy 6837: ibhs-nme35pyr-gly-betampy 6838: tolhs-me25thiaz-gly-zdap 6839: tolhs-25thiaz-bala-betaftrif 6840: ibhs-24thiaz-gly-betafbph i 6841: bhs-oxadiaz-ala-betadmph 6842: tolhs-oxadiaz-bala-betadito 6843: tolhs-25thiaz-bala-betamesu -211 6844: tolhs-25oxaz-gly-betadcphee 6845: gua-25thiaz-gly-beta35dbph 6846: tolhs-nme35pyr-gly-betaphethio 6847: gua-24oxaz-gly-beta34dcph 5 6848: 2py-24thiaz-ala-zdap 6849: tolhs-oxadiaz-gly-betafphe 6850: tolhs-25oxaz-gly-beta23meoph 6851: ibhs-24thiaz-bala-beta23meoph 6852: phhs-nme35pyr-gly-betahc 10 6853: gua-24oxaz-gly-betadmph 6854: bhs-25fur-gly-psdap 6855: bhs-24thiaz-gly-betadbph 6856: ibhs-25thiaz-gly-betabph 6857: 2py-triaz-ala-psdap 15 6858: tolhs-ithiadiaz-bala-csdap 6859: tolhs-ithiadiaz-gly-betadito 6860: tolhs-24thiaz-gly-betapyr 6861: bhs-ithiadiaz-gly-betafluo 6862: tolhs-24thioph-gly-betafu2 20 6863: ibhs-24thioph-gly-betathioph 6864: 2py-53pyrazo-bala-betadcph 6865: tolhs-oxadiaz-bala-betabenfu 6866: tolhs-25thiaz-bala-betahmo 6867: ibhs-oxadiaz-gly-betahb 25 6868: bhs-25thiaz-ala-betameph 6869: phhs-ithiadiaz-gly-betathiome 6870: phhs-oxadiaz-gly-betadbph 6871: tolhs-25oxaz-gly-betaoxope 6872: bhs-oxadiaz-bala-betadbph 30 6873: bhs-ithiadiaz-bala-betadcphee 6874: bhs-me24oxaz-gly-betadcph 6875: tolhs-25thiaz-gly-betaphethioa 6876: dhim-26py-ala-betameph 6877: tolhs-oxadiaz-gly-psdap 35 6878: tolhs-oxadiaz-bala-betahcbph 6879: bim-24thiaz-bala-aspbzla 6880: phhs-24thioph-gly-beta34dcph -212 6881: bim-42oxaz-leu-zdap 6882: phhs-25oxaz-bala-betathiobe 6883: tolhs-24thiaz-bala-betathio3 6884: 2py-35thioph-bala-zdap 5 6885: bim-25fur-bala-zdap 6886: bim-me25thioph-leu-psdap 6887: ibhs-25thiaz-giy-betafu2 6888: bhs-24thiaz-gly-betaamibe 6889: 2pmhs-24thiaz-gly-betameph 0 6890: ibhs-24thioph-gly-psdapee 6891: phhs-25methiaz-gly-psdapch 6892: ibhs-24thiaz-gly-suabu 6893: bhs-25thiaz-ala-betapy 6894: dhim-52thiaz-ala-psdap 5 6895: tolhs-25thiaz-gly-zdaptb 6896: ibhs-24thiaz-gly-aspibua 6897: 2pmhs-42nmeim-bala-beta23meoph 6898: 2py-52thiaz-gly-betapy 6899: bhs-ithiadiaz-gly-betathiome 0 6900: bhs-ithiadiaz-bala-betabnaphth 6901: 2py-24oxaz-leu-zdap 6902: tolhs-24thioph-bala-betaphethio 6903: bhs-35fur-gly-zdap 6904: hts-25thiaz-gly-betapy 5 6905: 2py-oxadiaz-bala-aspibua 6906: tolhs-nme35pyr-gly-betabdcph 6907: ibhs-ithiadiaz-bala-psdaptb 6908: ibhs-25methiaz-bala-betacbph 6909: 2py-25oxaz-bala-busu2be D 6910: bim-me25thiaz-leu-betaph 6911: phhs-25thiaz-bala-betaphethioa 6912: ibhs-ithiadiaz-bala-betafluo 6913: gua-25thioph-gly-betadcph 6914: bhs-25thiaz-bala-betaomebendi 5 6915: phhs-25methiaz-bala-betaet 6916: 2pmhs-42nmeim-bala-betahdbph 6917: bhs-35thioph-gly-zdap -213 6918: ibhs-oxadiaz-bala-ibsdap 6919: tolhs-24thiaz-gly-betaanaphth 6920: 2py-me24oxaz-leu-betadcph 6921: phhs-25methiaz-bala-psdapee 5 6922: pahs-42nmeim-bala-betadcph 6923: ibhs-oxadiaz-bala-betaol 6924: ibhs-25thiaz-gly-betapych 6925: bhs-42nmeim-leu-psdap 6926: tolhs-nme35pyr-gly-betadmoph 0 6927: phhs-24thioph-gly-ibsdap 6928: tolhs-me25thioph-gly-psdap 6929: phhs-25oxaz-gly-betaoxope 6930: bhs-oxadiaz-gly-aspaba 6931: tolhs-25thiaz-bala-betafluo 5 6932: tolhs-25methiaz-gly-betahb 6933: tolhs-ithiadiaz-gly-psdapee 6934: 2py-42nmeim-gly-betahc 6935: tolhs-25thiaz-gly-betaphethio 6936: bhs-ithiadiaz-bala-betamethi 0 6937: tolhs-25methiaz-gly-betabph 6938: bhs-24thioph-gly-betaanaphth 6939: phhs-25methiaz-gly-beta34meoph 6940: tolhs-25methiaz-gly-betadmoph 6941: bhs-24thiaz-gly-betadmph 5 6942: 2py-24thioph-gly-beta35dbph 6943: ibhs-25oxaz-gly-betabmph 6944: bhs-ithiadiaz-bala-beta34meoph 6945: bim-42oxaz-ala-betadcph 6946: tolhs-25methiaz-gly-betathiome 0 6947: ibhs-nme35pyr-bala-csdap 6948: bhs-ithiadiaz-ala-betamesu 6949: thpym-26py-gly-betahdcph 6950: 2py-ithiadiaz-bala-betapy 6951: tolhs-oxadiaz-gly-asppha 5 6952: bhs-nme35pyr-nmgly-betaanaphth 6953: phhs-25thiaz-bala-betahmo 6954: bhs-25oxaz-gly-betadhbfu -214 6955: bhs-24thiaz-nmgly-betacthioph 6956: tolhs-25thiaz-bala-ibsdap 6957: tolhs-nme35pyr-bala-beta23meoph 6958: bim-24thioph-gly-betadcph 5 6959: tolhs-24thioph-bala-betahc 6960: bhs-25thiaz-bala-betahcbph 6961: tolhs-24thiaz-bala-betadhbfu 6962: ibhs-25methiaz-bala-betadtrif 6963: phhs-25methiaz-bala-beta23meoph 0 6964: phhs-nme35pyr-bala-betampy 6965: bhs-25thiaz-gly-betahcbph 6966: bhs-ithiadiaz-ala-zdap 6967: tolhs-25thiaz-bala-betaimid 6968: phhs-25thiaz-gly-betaamibe 5 6969: bim-ithiadiaz-ala-betapy 6970: bhs-42pym-ala-betainyl 6971: tolhs-25thiaz-bala-betafu2 6972: 2pmhs-24thioph-gly-betathiome 6973: imhs-24thiaz-gly-zdap 0 6974: dhim-52thiaz-gly-betapy 6975: tolhs-24thioph-bala-betamesu 6976: phhs-ithiadiaz-bala-betahmo 6977: gua-25thiaz-gly-betaibph 6978: ibhs-24thiaz-bala-betadito 5 6979: phhs-nme35pyr-gly-betambiph 6980: dhpyrr-25thioph-gly-betapy 6981: bhs-25thiaz-nmgly-betal 3bendi 6982: bhs-42nmeim-gly-betaoxope 6983: bim-42pym-ala-betadcph 0 6984: tolhs-me24thioph-leu-psdap 6985: 2py-42nmeim-leu-betapy 6986: phhs-oxadiaz-bala-betamesu 6987: tolhs-24thioph-bala-aspaba 6988: dhim-26py-ala-zdap 5 6989: bhs-oxadiaz-bala-betampy 6990: ibhs-25thiaz-bala-betamethioph 6991: 2py-42pym-gly-betameph -215 6992: tolhs-ithiadiaz-bala-betadmph 6993: gua-24thiaz-gly-betahmo 6994: bhs-ithiadiaz-bala-betapym 6995: bhs-24thioph-ala-betacthioph 5 6996: bhs-24thiaz-bala-betahph 6997: phhs-ithiadiaz-gly-betadito 6998: phhs-me24oxaz-ala-betapy 6999: bhs-52thiaz-ala-betapy 7000: bhs-me25oxaz-ala-zdap 0 7001: ibhs-25oxaz-bala-betabenfu 7002: phhis-24thiaz-bala-beta34dcph 7003: ibhs-24thiaz-bala-betadcphch 7004: ibhs-25thiaz-gly-betatrif 7005: ibhs-oxadiaz-gly-betahbcph 5 7006: bhs-nme35pyr-bala-betaimid 7007: bhs-oxadiaz-bala-betaamibe 7008: phhs-25oxaz-bala-betafu2 7009: tolhs-24thioph-gly-betahbcph 7010: 2py-25fur-bala-betapy 0 7011: 2py-25oxaz-bala-betainyl 7012: tolhs-me25thiaz-leu-betaph 7013: bhs-ithiadiaz-bala-betadmph 7014: bhs-nme35pyr-gly-busu2be 7015: bhs-me24thiaz-gly-betadcph 5 7016: tolhs-oxadiaz-bala-suabu 7017: bhs-24thioph-ala-beta34meoph 7018: tolhs-24thiaz-bala-betabnaphth 7019: ibhs-25methiaz-gly-zdapee 7020: tolhs-24thiaz-bala-betacbph 3 7021: bhs-25thiaz-bala-betahni 7022: ibhs-oxadiaz-bala-betaheph 7023: phhs-25thiaz-bala-betapbiph 7024: ibhs-25oxaz-gly-betafu3 7025: tolhs-24thioph-bala-betadcph 5 7026: 2py-me25thiaz-bala-beta34meoph 7027: tolhs-ithiadiaz-gly-betaomebendi 7028: tolhs-24thiaz-bala-psdapch -216 7029: phhs-nme35pyr-bala-beta23meoph 7030: bhs-24thioph-gly-betadcphch 7031: phhs-nme35pyr-gly-betafph 7032: tolhs-24thioph-bala-betadcphtb 5 7033: bhs-nme35pyr-bala-betadmph 7034: bhs-oxadiaz-gly-betadcphtb 7035: phhs-ithiadiaz-gly-betapyr 7036: dhim-24thiaz-gly-betameph 7037: bgua-24thiaz-gly-betameph 0 7038: bhs-24thiaz-ala-betapy 7039: tolhs-24thiaz-bala-betaet 7040: ibhs-25thiaz-gly-betadbph 7041: 2py-26py-gly-betaanaphth 7042: bhs-25oxaz-bala-betadhbfu 5 7043: phhs-25oxaz-gly-betamethi 7044: bim-24im-gly-psdap 7045: tolhs-25oxaz-gly-betadhbf u 7046: gua-24oxaz-gly-betahb 7047: phhs-oxadiaz-bala-betaph 0 7048: ibhs-24thioph-bala-betaomebendi 7049: bhs-24thiaz-ala-beta3quin 7050: bhs-25oxaz-bala-beta34meoph 7051: ibhs-25methiaz-gly-beta4bph 7052: bhs-nme35pyr-bala-betapbiph 5 7053: phhs-25methiaz-bala-psdap 7054: bhs-25methiaz-bala-betahcbph 7055: bhs-oxadiaz-gly-betafu3 7056: phhs-oxadiaz-bala-betaanaphth 7057: 2py-42nmeim-gly-zdap D 7058: bhs-53pyrazo-leu-betadcph 7059: ibhs-25oxaz-bala-betahcbph 7060: gua-24thiaz-gly-betaol 7061: ibhs-nme35pyr-bala-aspaba 7062: impy-42nmeim-gly-betathioph 5 7063: tolhs-24thioph-bala-betahph 7064: bhs-24thiaz-bala-betamesu 7065: phhs-nme35pyr-gly-betathio3 -217 7066: 2py-24thioph-bala-betapy 7067: phhs-25thiaz-gly-betadcphch 7068: phhs-ithiadiaz-gly-betabdimo 7069: bim-me24thioph-ala-betadcph 5 7070: phhs-25methiaz-bala-zdaptb 7071: tolhs-25oxaz-gly-betafbph 7072: bgua-25thiaz-gly-betameph 7073: thazep-25thioph-gly-betadcph 7074: 2py-me24oxaz-gly-zdap 0 7075: tolhs-24thioph-gly-betadtrif 7076: tolhs-ithiadiaz-gly-betal 3bendi 7077: bhs-me25thioph-bala-psdap 7078: ibhs-nme35pyr-bala-betampy 7079: phhs-25oxaz-gly-betahni 5 7080: tolhs-24thioph-gly-betambiph 7081: 2py-25thiaz-hphe-psdap 7082: tolhs-25oxaz-bala-zdapch 7083: tolhs-nme35pyr-bala-beta3quin 7084: ibhs-25oxaz-bala-betahmph 0 7085: phhs-nme35pyr-gly-betadcphtb 7086: bhs-nme35pyr-gly-betadmph 7087: phhs-25methiaz-gly-betadmph 7088: ibhs-nme35pyr-gly-beta3quin 7089: ibhs-24thiaz-bala-betaibph 5 7090: bhs-25oxaz-bala-busu2be 7091: dhim-42pym-gly-zdap 7092: tolhs-25methiaz-bala-betatos 7093: phhs-nme35pyr-gly-betal 3bendi 7094: bhs-24thioph-gly-betabph ) 7095: tolhs-oxadiaz-bala-betaphethioa 7096: ibhs-nme35pyr-gly-betathiome 7097: bhs-oxadiaz-bala-betamesu 7098: bhs-oxadiaz-gly-zdapee 7099: phhs-oxadiaz-gly-beta3quin 5 7100: ibhs-25methiaz-gly-betaipr 7101: ibhs-nme35pyr-bala-betaphethioa 7102: gua-24oxaz-gly-betaol -218 7103: tolhs-24thiaz-bala-betapyee 7104: bhs-ithiadiaz-nmgly-betacthioph 7105: phhs-oxadiaz-gly-betadcphtb 7106: tolhs-ithiadiaz-gly-betabnaphth 5 7107: ibhs-25oxaz-bala-betabmph 7108: bim-52thiaz-ala-psdap 7109: tolhs-25methiaz-gly-betamesu 7110: hyd-25oxaz-gly-betapy 7111: bhs-24thioph-bala-betapyee 0 7112: 2py-26py-ala-betameph 7113: bim-25methiaz-gly-aspbzla 7114: ibhs-nme35pyr-gly-betadmph 7115: bim-25thiaz-bala-betadcph 7116: tolhs-24thioph-gly-betatrif 5 7117: phhs-24thiaz-gly-betamethioph 7118: tolhs-me24thiaz-ala-betadcph 7119: phhs-oxadiaz-gly-betadito 7120: tolhs-ithiadiaz-gly-beta34meoph 7121: bhs-ithiadiaz-gly-zdaptb .0 7122: impy-24thioph-bala-betah35dc 7123: ibhs-25oxaz-bala-betadbph 7124: 2py-25thioph-gly-betameph 7125: bim-25methiaz-bala-betahc 7126: tolhs-me24thioph-gly-betaph ?5 7127: tolhs-oxadiaz-gly-betaftrif 7128: ibhs-oxadiaz-gly-betathiobe 7129: tolhs-nme35pyr-gly-beta35dbph 7130: ibhs-nme35pyr-bala-ibsdap 7131: phhs-25oxaz-gly-betahmph 30 7132: bhs-oxadiaz-ala-betadhbfu 7133: impy-25thiaz-bala-betamethi 7134: ibhs-nme35pyr-bala-psdapch 7135: bhs-me25oxaz-ala-psdap 7136: bhs-ithiadiaz-nmgly-betahph 35 7137: bhs-oxadiaz-ala-betacthioph 7138: dhim-26py-phe-zdap 7139: bhs-24thioph-bala-betah35dc -219 7140: bhs-oxadiaz-bala-busu2be 7141: ibhs-25thiaz-gly-betaol 7142: bhs-oxadiaz-bala-betatbuph 7143: ibhs-nme35pyr-bala-betaipro 5 7144: bhs-me24thioph-leu-betaph 7145: ibhs-24thioph-gly-betampy 7146: phhs-oxadiaz-gly-psdap 7147: bhs-nme35pyr-gly-betamethioph 7148: bhs-25methiaz-bala-betathio3 0 7149: tolhs-24thiaz-bala-betainyl 7150: phhs-me25thioph-leu-beta34meoph 7151: 2py-me25thiaz-leu-psdap 7152: bhs-ithiadiaz-bala-aspbzla 7153: thpy-42nmeim-gly-psdap 5 7154: phhs-24thioph-gly-betainyl 7155: phhs-25methiaz-gly-betambiph 7156: ibhs-nme35pyr-gly-suabu 7157: bhs-oxadiaz-gly-betameph 7158: impy-24thiaz-gly-beta34meoph 0 7159: ibhs-nme35pyr-bala-betatbuph 7160: ibhs-24thioph-gly-busu2be 7161: bhs-24thioph-gly-betamesu 7162: tolhs-ithiadiaz-gly-zdap 7163: gua-25thiaz-gly-betameph 5 7164: ibhs-nme35pyr-gly-betacthioph 7165: bhs-24im-leu-psdap 7166: ibhs-24thiaz-bala-betacbph 7167: bhs-oxadiaz-bala-betahni 7168: tolhs-24thiaz-gly-betapyee 0 7169: ibhs-24thioph-bala-betapyr 7170: phhs-nme35pyr-gly-beta34meoph 7171: bhs-24thiaz-ala-betadito 7172: bim-42nmeim-bala-betabthioph 7173: bhs-24thiaz-bala-betacbph 5 7174: ibhs-nme35pyr-bala-betabph 7175: phhs-ithiadiaz-gly-betahmph 7176: tolhs-ithiadiaz-bala-psdaptb -220 7177: ibhs-25oxaz-bala-betadmoph 7178: tolhs-me24oxaz-ala-zdap 7179: ibhs-ithiadiaz-bala-betahcbph 7180: ibhs-25methiaz-bala-betathioph 5 7181: tolhs-25methiaz-gly-psdaptb 7182: tolhs-25oxaz-bala-betaph 7183: bhs-25thiaz-ala-betadmph 7184: bhs-24oxaz-bala-betadcph 7185: ibhs-24thioph-bala-psdapee 0 7186: bhs-ithiadiaz-gly-betapyr 7187: bhs-42nmeim-bala-betadito 7188: bim-24thiaz-bala-asppha 7189: bhs-24thiaz-gly-beta23meoph 7190: bhs-nme35pyr-nmgly-betacph 5 7191: bhs-24oxaz-leu-betapy 7192: impy-24thiaz-bala-betaphethioa 7193: phhs-ithiadiaz-gly-asppha 7194: phhs-25methiaz-gly-betapyr 7195: phhs-24thioph-gly-betaph D 7196: dhim-26py-ala-psdap 7197: ibhs-24thioph-bala-betafu3 7198: ibhs-ithiadiaz-bala-betahb 7199: bhs-ithiadiaz-gly-betaomebendi 7200: phhs-25oxaz-bala-betabenfu 5 7201: tolhs-25thiaz-bala-betaipro 7202: phhs-25oxaz-bala-betal 3bendi 7203: tolhs-oxadiaz-gly-betahc 7204: ibhs-25thiaz-bala-betadcphtb 7205: bhs-me24oxaz-bala-psdap 3 7206: ibhs-nme35pyr-bala-zdapee 7207: phhs-24thioph-bala-betainyl 7208: ibhs-24thioph-gly-zdap 7209: bhs-25methiaz-ala-betaanaphth 7210: tolhs-24thioph-gly-betapyee 5 7211: phhs-25thiaz-bala-ibsdap 7212: tolhs-24thiaz-gly-betabenfu 7213: bhs-oxadiaz-ala-beta23meoph -221 7214: bhs-25methiaz-ala-beta3quin 7215: phhs-25thiaz-gly-betaimid 7216: ibhs-nme35pyr-bala-beta34dcph 7217: ibhs-oxadiaz-gly-betahcbph 5 7218: ibhs-nme35pyr-gly-aspbzla 7219: 2py-25oxaz-ala-betapy 7220: gua-24thiaz-gly-betahdbph 7221: phhs-nme35pyr-bala-betaph 7222: bhs-nme35pyr-bala-betahdbph 0 7223: bhs-24thiaz-gly-betafph 7224: tolhs-25thiaz-bala-zdapch 7225: ibhs-24thiaz-gly-betapy 7226: tolhs-nme35pyr-bala-betadito 7227: phhs-25thiaz-bala-betafluo 5 7228: tolhs-24thiaz-gly-betaimid 7229: bhs-oxadiaz-gly-betafphe 7230: tolhs-me24thiaz-gly-betaph 7231: bim-53pyrazo-leu-psdap 7232: thazep-26py-gly-betainyl 0 7233: tolhs-nme35pyr-bala-betafluo 7234: tolhs-25methiaz-bala-betal 3bendi 7235: bhs-25thioph-bala-psdap 7236: 2pmhs-24thiaz-gly-betathiome 7237: 2py-25oxaz-gly-betabthioph 5 7238: bhs-25thiaz-bala-betaoxope 7239: bhs-25oxaz-gly-betapych 7240: ibhs-25oxaz-gly-betahmph 7241: bhs-25oxaz-gly-betaet 7242: gua-26py-gly-betainyl 0 7243: bim-53pyrazo-gly-betadcph 7244: 2py-25oxaz-bala-aspaba 7245: bhs-me25thioph-bala-betadcph 7246: ibhs-25methiaz-bala-betabpy 7247: bhs-24oxaz-gly-psdap 5 7248: bhs-25thiaz-bala-zdapch 7249: tolhs-24thiaz-bala-betaimid 7250: ibhs-24thioph-gly-beta34meoph -222 7251: tolhs-25methiaz-bala-betaipr 7252: bhs-nme35pyr-bala-betadcphee 7253: tolhs-oxadiaz-gly-betabph 7254: gua-24thiaz-gly-betaheph 5 7255: tolhs-nme35pyr-gly-zdaptb 7256: ibhs-25oxaz-bala-betahmo 7257: bim-me25oxaz-leu-beta34meoph 7258: 2py-24im-ala-betapy 7259: bhs-24thiaz-nmgly-betainyl ) 7260: phhs-25thiaz-bala-betaipr 7261: bhs-24thiaz-gly-asppha 7262: 2py-53pyrazo-leu-betadcph 7263: bhs-me24thioph-bala-betadcph 7264: dhim-26py-gly-betameph 5 7265: bhs-nme35pyr-ala-betamesu 7266: ibhs-25oxaz-gly-betabpy 7267: bhs-thiadiaz-gly-psdap 7268: bim-25methiaz-leu-zdap 7269: phhs-24thiaz-bala-betabnaphth 7270: ibhs-nme35pyr-gly-betadmoph 7271: 2py-25thiaz-bala-betaheph 7272: dhpyrr-24thioph-gly-betapy 7273: phhs-me24thiaz-gly-betadcph 7274: tolhs-24thioph-gly-betahc i 7275: bhs-24thiaz-gly-betahdbph 7276: bim-25oxaz-gly-betaph 7277: bim-nme35pyr-bala-aspbzla 7278: tolhs-nme35pyr-gly-zdap 7279: bhs-25methiaz-bala-psdapee 7280: 2py-me24thiaz-leu-betapy 7281: bhs-oxadiaz-nmgly-beta3quin 7282: tolhs-24thiaz-gly-betahph 7283: bhs-25thiaz-phg-betameph 7284: tolhs-me25oxaz-leu-betapy 7285: 2py-24thioph-bala-betafluo 7286: tolhs-25oxaz-bala-betaheph 7287: ibhs-25thiaz-bala-betabenfu -223 7288: phhs-nme35pyr-gly-ibsdap 7289: ibhs-24thioph-bala-betamethi 7290: ibhs-24thioph-bala-betaphethio 7291: ibhs-24thioph-gly-suabu 5 7292: bhs-25methiaz-bala-betabph 7293: 2py-25methiaz-bala-betabnaphth 7294: tolhs-24thioph-bala-betahni 7295: bhs-nme35pyr-gly-betainyl 7296: ibhs-25methiaz-gly-betadito D 7297: impy-25methiaz-gly-betacbph 7298: ibhs-oxadiaz-gly-betafphe 7299: bhs-oxadiaz-gly-betambiph 7300: bhs-nme35pyr-ala-betathio3 7301: bhs-25methiaz-gly-betapytb 5 7302: 2py-25oxaz-bala-zdap 7303: phhs-24thiaz-gly-betahmo 7304: bim-24thioph-ala-psdap 7305: bim-me24oxaz-ala-betadcph 7306: bhs-24thioph-gly-betafu2 D 7307: ibhs-25thiaz-gly-betapytb 7308: ibhs-24thioph-bala-betameph 7309: phhs-oxadiaz-gly-betafu3 7310: ibhs-25thiaz-gly-betambiph 7311: ibhs-oxadiaz-gly-betathioph 5 7312: phhs-25methiaz-bala-betahbcph 7313: bim-24thiaz-gly-zdap 7314: bhs-25fur-bala-betadcph 7315: tolhs-oxadiaz-bala-betatrif 7316: bhs-24im-bala-betadcph D 7317: tolhs-25methiaz-bala-zdap 7318: phhs-ithiadiaz-gly-betadcphee 7319: ibhs-25methiaz-bala-betaftrif 7320: tolhs-nme35pyr-gly-betapy 7321: phhs-25methiaz-gly-betabmph 5 7322: dhthi-42nmeim-bala-psdap 7323: tolhs-24thiaz-bala-beta34dcph 7324: tolhs-me25thiaz-leu-zdap -224 7325: 2py-me25thiaz-bala-betaph 7326: bhs-25methiaz-ala-zdap 7327: bhs-24thioph-nmgly-betadmph 7328: bhs-24thiaz-leu-zdap 5 7329: ibhs-24thiaz-bala-betabdimo 7330: tolhs-25oxaz-gly-psdaptb 7331: phhs-me24thioph-ala-beta34meoph 7332: bim-25thiaz-phg-zdap 7333: ibhs-24thiaz-gly-betapym 0 7334: bim-me25thiaz-ala-betapy 7335: 2py-42oxaz-bala-betapy 7336: bim-42oxaz-gly-betapy 7337: bhs-25oxaz-gly-betapytb 7338: bhs-25oxaz-gly-betapyee 5 7339: gua-42pym-gly-betabdimo 7340: bhs-26py-gly-betameph 7341: impy-26py-gly-psdap 7342: bhs-25oxaz-bala-betabediox 7343: tolhs-oxadiaz-bala-zdapee 0 7344: bhs-nme35pyr-gly-betathiobe 7345: tolhs-25methiaz-gly-betaomebendi 7346: ibhs-24thioph-bala-betampy 7347: ibhs-24thiaz-bala-betapbiph 7348: ibhs-24thioph-bala-psdapch 5 7349: phhs-24thiaz-bala-betaet 7350: bhs-25methiaz-bala-betaoxaz 7351: bhs-me24thioph-leu-betadcph 7352: 2py-25thioph-bala-betadcph 7353: tolhs-ithiadiaz-gly-betathiobe D 7354: bhs-25methiaz-bala-betathiome 7355: bhs-oxadiaz-gly-betaoxope 7356: bhs-24thiaz-bala-betabnaphth 7357: phhs-nme35pyr-bala-betahph 7358: ibhs-25thiaz-gly-zdaptb 5 7359: bhs-oxadiaz-ala-betahph 7360: ibhs-42nmeim-gly-betameph 7361: ibhs-24thioph-bala-betaol -225 7362: tolhs-24thioph-bala-betah35dc 7363: ibhs-24thiaz-gly-betadcphtb 7364: bhs-25thiaz-gly-betabenfu 7365: tolhs-ithiadiaz-bala-betaoxope 5 7366: ibhs-oxadiaz-gly-betaheph 7367: bhs-24thiaz-ala-betacthioph 7368: ibhs-24thioph-gly-betapbiph 7369: bhs-oxadiaz-nmgly-betathio3 7370: bim-me25thiaz-ala-betaph 0 7371: ibhs-oxadiaz-gly-betahph 7372: gua-42pym-gly-betampy 7373: tolhs-25oxaz-gly-betafu2 7374: phhs-nme35pyr-bala-betaoxope 7375: ibhs-nme35pyr-bala-betaimid 5 7376: bhs-25oxaz-gly-psdapee 7377: bhs-25thiaz-nmgly-betacph 7378: tolhs-24thioph-bala-aspbzla 7379: ibhs-25methiaz-gly-psdapee 7380: tolhs-25thiaz-gly-betafph 0 7381: phhs-ithiadiaz-gly-betaphethio 7382: ibhs-ithiadiaz-bala-betafu3 7383: ibhs-25oxaz-bala-betadcphee 7384: phhs-25methiaz-gly-betaanaphth 7385: phhs-ithiadiaz-gly-zdapee 5 7386: bim-ithiadiaz-gly-aspibua 7387: phhs-25oxaz-bala-betaheph 7388: tolhs-25methiaz-gly-zdaptb 7389: bhs-oxadiaz-ala-betainyl 7390: tolhs-24thioph-gly-ibsdap 0 7391: 2py-nme35pyr-gly-zdap 7392: bim-24thiaz-bala-betahc 7393: 2py-me25thioph-bala-zdap 7394: imhs-25oxaz-bala-psdap 7395: bhs-24thioph-bala-betahni 5 7396: tolhs-24thioph-gly-betaet 7397: ibhs-25thiaz-gly-betahdbph 7398: phhs-nme35pyr-gly-psdapee -226 7399: phhs-oxadiaz-gly-betahbcph 7400: hyd-24thioph-bala-betameph 7401: phhs-25thiaz-bala-busu2be 7402: tolhs-24thioph-gly-betahph 5 7403: 2py-24thioph-bala-betaheph 7404: tolhs-nme35pyr-bala-beta1 3bendi 7405: bhs-ithiadiaz-gly-betahb 7406: bhs-oxadiaz-bala-betaibph 7407: ibhs-25methiaz-gly-betafphe 0 7408: phhs-24thiaz-gly-betahph 7409: 2py-24thioph-leu-psdap 7410: phhs-nme35pyr-bala-betadcphtb 7411: ibhs-24thiaz-gly-betadcphch 7412: 2py-24thiophme-ala-betapy 5 7413: bhs-24thioph-bala-psdaptb 7414: ibhs-25methiaz-bala-betabenfu 7415: 2py-ithiadiaz-leu-betapy 7416: bim-42nmeim-leu-psdap 7417: gua-42pym-gly-betahmph D 7418: phhs-25methiaz-gly-betabpy 7419: tolhs-24thioph-gly-betaamibe 7420: bhs-25oxaz-bala-psdapee 7421: 2pmhs-25methiaz-bala-betamethioph 7422: dimethpym-24thiaz-gly-betahdcph 5 7423: bhs-24thiaz-bala-betah35dc 7424: tolhs-24thioph-bala-betabenfu 7425: bim-24thioph-ala-betadcph 7426: phhs-25methiaz-bala-betamesu 7427: bhs-nme35pyr-bala-betathiobe 7428: phhs-ithiadiaz-gly-zdap 7429: phhs-ithiadiaz-bala-betameph 7430: tolhs-nme35pyr-bala-betambiph 7431: bhs-35fur-leu-betapy 7432: phhs-25thiaz-gly-betaanaphth 5 7433: bhs-me24thiaz-gly-betaph 7434: bhs-25methiaz-bala-betameph 7435: ibhs-nme35pyr-bala-psdaptb -227 7436: phhs-me24thioph-bala-beta34meoph 7437: bhs-25thiaz-gly-betaomebendi 7438: bhs-25thiaz-gly-betadbph 7439: bhs-25methiaz-gly-betamethi 5 7440: gua-24oxaz-gly-betaet 7441: phhs-24thioph-gly-suabu 7442: bhs-42nmeim-bala-beta35dbph 7443: ibhs-25thiaz-gly-betahmo 7444: bhs-24thiaz-gly-zdapee 0 7445: ibhs-24thiaz-bala-betahdbph 7446: ibhs-24thioph-gly-betahb 7447: bim-25oxaz-gly-betadtrif 7448: bhs-24thioph-ala-betahph 7449: bhs-25oxaz-leu-psdap 5 7450: bhs-nme35pyr-bala-betainyl 7451: bhs-ithiadiaz-ala-beta3quin 7452: phhs-24thiaz-bala-betahdcph 7453: bim-me25thiaz-leu-betapy 7454: 2py-25thiaz-gly-betainyl 0 7455: tolhs-25oxaz-gly-betal 3bendi 7456: tolhs-24thiaz-bala-beta4bph 7457: tolhs-ithiadiaz-bala-betampy 7458: bhs-25oxaz-gly-betafphe 7459: tolhs-ithiadiaz-bala-betahmph 5 7460: ibhs-25thiaz-gly-betaphethioa 7461: ibhs-24thioph-bala-betacph 7462: bhs-25methiaz-bala-betaamibe 7463: phhs-me25thioph-leu-psdap 7464: 2py-me25thiaz-leu-beta34meoph D 7465: ibhs-ithiadiaz-bala-betaamibe 7466: phhs-oxadiaz-bala-betaoxaz 7467: phhs-nme35pyr-gly-betaphethioa 7468: bhs-24thiaz-gly-betabpy 7469: tolhs-ithiadiaz-bala-betamethioph 5 7470: bim-24oxaz-leu-psdap 7471: bhs-thiadiaz-leu-psdap 7472: 2py-oxadiaz-gly-aspaba -228 7473: 2py-42nmeim-gly-psdap 7474: impy-25methiaz-gly-betathiobe 7475: tolhs-25oxaz-bala-betampy 7476: ibhs-25oxaz-bala-aspbzla 5 7477: ibhs-25thiaz-bala-betaamibe 7478: phhs-24thioph-gly-betabmph 7479: ibhs-25thiaz-bala-betaet 7480: ibhs-25methiaz-bala-betaoxope 7481: bhs-nme35pyr-bala-betaibph 7482: tolhs-25oxaz-gly-betapbiph 7483: 2py-25methiaz-bala-suabu 7484: tolhs-ithiadiaz-gly-betadcph 7485: 2pmhs-42nmeim-gly-betaoxaz 7486: ibhs-25methiaz-bala-psdaptb 7487: bhs-25methiaz-bala-betaomebendi 7488: impy-25oxaz-gly-beta23meoph 7489: bhs-nme35pyr-gly-psdaptb 7490: bhs-24thioph-gly-betacph 7491: bhs-25oxaz-bala-aspibua 7492: tolhs-nme35pyr-bala-zdapee 7493: bhs-25methiaz-bala-betamesu 7494: 2py-42oxaz-leu-betadcph 7495: ibhs-25thiaz-gly-betadmoph 7496: bhs-nme35pyr-bala-betaipro 7497: bim-42nmeim-gly-betainyl 7498: phhs-nme35pyr-gly-betaph 7499: tolhs-25methiaz-bala-betafph 7500: tolhs-24thioph-bala-psdap 7501: bhs-25thioph-ala-betameph 7502: tolhs-25oxaz-bala-betaoxaz 7503: phhs-25thiaz-bala-betahmofu 7504: bim-24thioph-gly-asppha 7505: phhs-25oxaz-bala-betatbuph 7506: bhs-oxadiaz-ala-betamesu 7507: ibhs-24thioph-gly-betabthioph 7508: 2pmhs-24thiaz-bala-betahph 7509: phhs-25oxaz-gly-betabthioph -229 7510: phhs-24thioph-bala-betaoxope 7511: bhs-ithiadiaz-bala-ibsdap 7512: ibhs-25thiaz-gly-zdapee 7513: bhs-25oxaz-bala-betafbph 5 7514: tolhs-25oxaz-gly-betabthioph 7515: bhs-me25thioph-bala-beta34meoph 7516: impy-25methiaz-gly-betaipr 7517: phhs-25thiaz-gly-betadcphtb 7518: bhs-24thiaz-bala-betaipr 0 7519: tolhs-24thioph-gly-psdapch 7520: bhs-me24oxaz-gly-betapy 7521: phhs-nme35pyr-bala-betathio3 7522: bhs-nme35pyr-gly-betabenfu 7523: phhs-25methiaz-bala-betadito 5 7524: ibhs-nme35pyr-bala-betadcphtb 7525: tolhs-24thioph-gly-aspaba 7526: 2py-35thioph-bala-psdap 7527: bim-me25thiaz-bala-psdap 7528: gua-25thioph-gly-beta3quin 0 7529: gua-42pym-gly-betathiome 7530: phhs-25methiaz-gly-beta23meoph 7531: phhs-25thiaz-gly-betadbph 7532: tolhs-24thiaz-gly-ibsdap 7533: bim-25oxaz-ala-betadcph 5 7534: 2py-25thiaz-bala-psdap 7535: phhs-ithiadiaz-bala-betahbcph 7536: ibhs-ithiadiaz-gly-betahmo 7537: bhs-25oxaz-gly-betadito 7538: 2pmhs-25oxaz-gly-betacthioph 0 7539: bhs-me25thiaz-ala-beta34meoph 7540: ibhs-25thiaz-gly-betahmph 7541: bhs-nme35pyr-bala-betahc 7542: tolhs-24thioph-bala-busu2be 7543: ibhs-nme35pyr-gly-betahph 5 7544: bim-24thioph-gly-betaanaphth 7545: phhs-oxadiaz-bala-csdap 7546: phhs-25thiaz-gly-psdaptb -230 7547: bim-24oxaz-leu-betadcph 7548: phhs-24thiaz-bala-betahc 7549: phhs-25methiaz-bala-aspaba 7550: tolhs-25oxaz-gly-betacph 5 7551: bhs-24thiaz-gly-betahni 7552: ibhs-25oxaz-gly-busu2be 7553: bhs-24thiaz-bala-betahmofu 7554: phhs-25oxaz-bala-betaipro 7555: impy-24thiaz-gly-betacbph 0 7556: ibhs-25methiaz-bala-betafph 7557: tolhs-24thiaz-gly-betathiobe 7558: ibhs-ithiadiaz-bala-beta4bph 7559: bhs-24thiaz-bala-betambiph 7560: gua-24thiaz-gly-betathiobe 5 7561: bgua-24thiaz-gly-betapy 7562: tolhs-ithiadiaz-bala-betathioph 7563: bhs-42pym-gly-betacph 7564: phhs-ithiadiaz-bala-betadito 7565: bhs-nme35pyr-bala-aspaba 0 7566: bhs-24thioph-bala-betaipr 7567: ibhs-24thioph-bala-betaanaphth 7568: dhpyrr-26py-gly-betapy 7569: tolhs-25methiaz-bala-betaomebendi 7570: bhs-ithiadiaz-bala-betahph 5 7571: bhs-nm35pyr-gly-beta4bph 7572: bim-oxadiaz-gly-aspbzla 7573: phhs-25thiaz-bala-betabnaphth 7574: phhs-24thioph-gly-betaipro 7575: phhs-25thiaz-gly-beta4bph 0 7576: ibhs-25thiaz-bala-betathio3 7577: ibhs-25thiaz-bala-betabpy 7578: phhs-oxadiaz-bala-beta34dcph 7579: bhs-25oxaz-bala-betaomebendi 7580: tolhs-24thiaz-gly-betamethioph 5 7581: 2py-42nmeim-bala-betapbiph 7582: ibhs-oxadiaz-gly-beta35dbph 7583: bhs-nme35pyr-bala-beta23meoph -231 7584: tolhs-nme35pyr-gly-betabthioph 7585: tolhs-oxadiaz-gly-betabmph 7586: bhs-25thiaz-ala-betadcph 7587: 2py-42pym-ala-betameph 5 7588: bhs-24thiaz-bala-betameph 7589: ibhs-25thiaz-gly-betaibph 7590: tolhs-ithiadiaz-gly-betambiph 7591: bhs-triaz-leu-betadcph 7592: tolhs-25oxaz-gly-betaphethio 0 7593: tolhs-24thioph-bala-betahdcph 7594: tolhs-25oxaz-gly-betafluo 7595: bhs-me25oxaz-ala-beta34meoph 7596: bhs-24thioph-bala-zdap 7597: ibhs-oxadiaz-gly-betaipr 5 7598: tolhs-25methiaz-bala-betahdbph 7599: bhs-me25thioph-leu-zdap 7600: tolhs-24thiaz-gly-betadmoph 7601: phhs-25thiaz-gly-betaftrif 7602: tolhs-25methiaz-gly-betahmofu 0 7603: bhs-oxadiaz-bala-betaphethioa 7604: phhs-25thiaz-bala-betadmph 7605: phhs-24thiaz-gly-betapych 7606: bhs-me24thiaz-gly-beta34meoph 7607: bhs-24thioph-gly-betahni 5 7608: bhs-25thiaz-gly-betadcphch 7609: tolhs-oxadiaz-bala-betamethi 7610: ibhs-25methiaz-gly-betameph 7611: phhs-25oxaz-gly-beta4bph 7612: tolhs-24thiaz-gly-aspibua 0 7613: 2py-24thiaz-gly-betatbuph 7614: phhs-oxadiaz-gly-betah35dc 7615: phhs-ithiadiaz-gly-betapy 7616: bhs-25oxaz-bala-betabthioph 7617: tolhs-oxadiaz-gly-betathiobe 5 7618: bhs-25thiaz-gly-betahdbph 7619: ibhs-25oxaz-gly-betahc 7620: 2py-35thioph-bala-betadcph -232 7621: bim-me24thiaz-leu-beta34meoph 7622: tolhs-24thiaz-bala-betafphe 7623: 2py-26py-phg-zdap 7624: bhs-24thioph-gly-beta34meoph 5 7625: tolhs-oxadiaz-bala-betamethioph 7626: phhs-nme35pyr-bala-betamethi 7627: bhs-ithiadiaz-ala-betahph 7628: phhs-25oxaz-gly-betafu2 7629: bhs-nme35pyr-bala-zdapch ) 7630: bhs-24thioph-gly-aspaba 7631: tolhs-25thiaz-gly-betadmoph 7632: tolhs-24thioph-bala-betatos 7633: bhs-25oxaz-bala-betadito 7634: bhs-53pyrazo-leu-psdap 5 7635: ibhs-oxadiaz-gly-betaipro 7636: 2py-1 2me35pyr-gly-asppha 7637: thpy-25thiaz-gly-betadcph 7638: gua-25thiaz-gly-betaftrif 7639: bim-nme35pyr-bala-zdap 3 7640: phhs-25thiaz-gly-betapym 7641: bim-42nmeim-ala-psdap 7642: bhs-24thioph-bala-beta35dbph 7643: tolhs-25oxaz-bala-betaf ph 7644: tolhs-25methiaz-gly-betaimid 5 7645: phhs-me25oxaz-bala-beta34meoph 7646: bim-me25thioph-leu-betapy 7647: phhs-24thiaz-gly-betaheph 7648: ibhs-25oxaz-bala-csdap 7649: tolhs-me24oxaz-leu-zdap 3 7650: bhs-oxadiaz-bala-betah35dc 7651: bhs-24thioph-nmgly-beta3quin 7652: tolhs-25oxaz-bala-psdaptb 7653: bhs-nme35pyr-gly-betaibph 7654: bhs-oxadiaz-bala-betafluo 5 7655: dimethpym-25oxaz-bala-betapy 7656: tolhs-nme35pyr-bala-betafu2 7657: phhs-nme35pyr-bala-betatbuph -233 7658: bhs-25oxaz-bala-psdap 7659: bim-oxadiaz-gly-aspaba 7660: tolhs-ithiadiaz-gly-betabdimo 7661: bhs-24thioph-bala-betafphe 5 7662: tolhs-25oxaz-gly-busu2be 7663: bim-35pyrazo-ala-zdap 7664: impy-24thiaz-bala-busu2be 7665: gua-24thiaz-gly-betatrif 7666: phhs-me25oxaz-gly-betadcph 0 7667: phhs-me24thioph-leu-zdap 7668: phhs-24thioph-gly-betadcph 7669: tolhs-ithiadiaz-bala-betatos 7670: bhs-ithiadiaz-gly-betafphe 7671: phhs-ithiadiaz-bala-betadcphtb 5 7672: bhs-24thioph-bala-betahbcph 7673: bhs-ithiadiaz-gly-zdapch 7674: bim-42nmeim-ala-zdap 7675: toihs-25methiaz-gly-betadcphtb 7676: tolhs-nme35pyr-gly-betafu3 0 7677: bhs-24thiaz-phg-betapy 7678: ibhs-ithiadiaz-gly-suabu 7679: dhpyrr-25oxaz-bala-betadcph 7680: ibhs-oxadiaz-gly-betapbiph 7681: ibhs-25oxaz-bala-betathiome 5 7682: hts-24oxaz-gly-betapy 7683: tolhs-25oxaz-gly-psdapch 7684: phhs-25methiaz-gly-betal 3bendi 7685: bim-25thiaz-bala-zdap 7686: gua-42pym-gly-betahdcph 0 7687: phhs-25oxaz-gly-betaanaphth 7688: phhs-ithiadiaz-gly-betathio3 7689: bhs-nme35pyr-gly-beta34meoph 7690: bhs-25thiaz-gly-betafu3 7691: bim-24thiaz-ala-betapy 5 7692: tolhs-ithiadiaz-gly-betabpy 7693: ibhs-25thiaz-bala-beta4bph 7694: tolhs-nme35pyr-bala-betadmph -234 7695: ibhs-24thioph-gly-betathio3 7696: bhs-24thioph-gly-betainyl 7697: ur-42nmeim-gly-psdap 7698: phhs-25oxaz-bala-betacthioph 5 7699: bim-24thioph-bala-aspaba 7700: bim-me24oxaz-bala-betapy 7701: ibhs-nme35pyr-bala-betadmph 7702: ibhs-24thiaz-bala-betadcph 7703: tolhs-25oxaz-gly-betabdimo 0 7704: bhs-nme35pyr-gly-beta23meoph 7705: bhs-nme35pyr-bala-betafu3 7706: cima-42pym-gly-betainyl 7707: tolhs-oxadiaz-bala-betadcphtb 7708: 2py-me24thioph-ala-zdap 5 7709: phhs-25oxaz-bala-betaet 7710: ibhs-oxadiaz-gly-betambiph 7711: bhs-ithiadiaz-bala-betaet 7712: gua-24oxaz-gly-betadcph 7713: tolhs-25methiaz-gly-betaph ) 7714: bhs-25thiaz-gly-betacph 7715: impy-25oxaz-bala-betaoxaz 7716: ibhs-oxadiaz-bala-beta35dbph 7717: phhs-ithiadiaz-bala-beta34meoph 7718: 2py-35thioph-gly-psdap i 7719: tolhs-nme35pyr-bala-betadcphtb 7720: dhim-52thiaz-gly-betainyl 7721: bhs-25methiaz-nmgly-betathioph 7722: tolhs-24thioph-gly-betaimid 7723: bhs-25methiaz-bala-betaheph 7724: phhs-nme35pyr-bala-betahdbph 7725: phhs-25thiaz-gly-psdap 7726: bhs-ithiadiaz-gly-betadcph 7727: tolhs-nme35pyr-bala-betabpy 7728: ibhs-25thiaz-bala-psdaptb 7729: 2py-25thiaz-gly-aspbzla 7730: phhs-25oxaz-gly-betabph 7731: phhs-25oxaz-gly-betamesu -235 7732: bhs-oxadiaz-ala-betabnaphth 7733: bhs-nme35pyr-bala-betafbph 7734: tolhs-24thioph-bala-betadito 7735: ibhs-25thiaz-bala-psdap 5 7736: tolhs-25thiaz-bala-betabdimo 7737: bhs-25thiaz-gly-zdapch 7738: phhs-me25thiaz-bala-betapy 7739: phhs-24thiaz-gly-betapbiph 7740: tolhs-oxadiaz-bala-betaphethio 0 7741: hs-26py-gly-betapy 7742: bhs-24thioph-gly-aspibua 7743: phhs-nme35pyr-bala-betabdimo 7744: gua-24thiaz-gly-betathio3 7745: bhs-25methiaz-gly-betabpy 5 7746: dhim-42pym-gly-psdap 7747: ibhs-25thiaz-gly-asppha 7748: tolhs-nme35pyr-gly-betathiobe 7749: 2py-me24oxaz-leu-psdap 7750: phhs-25thiaz-bala-zdaptb D 7751: 2py-42pym-ala-betapy 7752: phhs-25methiaz-bala-betahdcph 7753: phhs-25oxaz-gly-psdapee 7754: ibhs-24thiaz-gly-betambiph 7755: phhs-oxadiaz-gly-zdap 5 7756: bhs-35thioph-leu-psdap 7757: tolhs-ithiadiaz-gly-betathioph 7758: bim-25fur-leu-zdap 7759: gua-24thiaz-gly-betadmph 7760: phhs-ithiadiaz-gly-betatrif 3 7761: gua-42pym-gly-betapy 7762: phhs-25oxaz-bala-betaol 7763: bim-oxadiaz-gly-zdap 7764: ibhs-oxadiaz-gly-betainyl 7765: bhs-25methiaz-bala-betadbph 5 7766: phhs-24thiaz-gly-betabdimo 7767: bhs-25thiaz-nmgly-beta23meoph 7768: bhs-25thiaz-gly-betathiome -236 7769: tolhs-me25thiaz-ala-betadcph 7770: bhs-me25oxaz-bala-psdap 7771: bhs-nme35pyr-bala-betadbph 7772: bhs-25methiaz-gly-betathioph 5 7773: bhs-24thioph-nmgly-beta34dcph 7774: ibhs-25methiaz-bala-betadmoph 7775: phhs-24thioph-bala-betaheph 7776: bhs-25oxaz-bala-betabph 7777: bhs-oxadiaz-ala-betahmph 0 7778: phhs-nme35pyr-bala-betaimid 7779: ibhs-oxadiaz-bala-betapym 7780: ibhs-25thiaz-gly-betafphe 7781: 2py-24thiaz-gly-psdap 7782: tolhs-24thiaz-gly-betathiome 5 7783: bhs-ithiadiaz-nmgly-betaoxaz 7784: thazep-24oxaz-gly-betapy 7785: phhs-oxadiaz-bala-psdap 7786: ibhs-25oxaz-gly-beta4bph 7787: phhs-25thiaz-gly-betapyee D 7788: bhs-35thioph-gly-betapy 7789: 2py-35fur-1eu-psdap 7790: tolhs-24thioph-gly-aspibua 7791: tolhs-24thioph-bala-betaftrif 7792: bhs-25methiaz-gly-betahc 5 7793: tolhs-24thiaz-gly-psdapee 7794: bim-24thiaz-gly-betapy 7795: tolhs-25thiaz-bala-betaibph 7796: tolhs-me24thiaz-leu-betadcph 7797: 2py-me24oxaz-bala-beta34meoph ) 7798: bhs-nme35pyr-nmgly-betal 3bendi 7799: phhs-25oxaz-gly-betafphe 7800: bhs-nme35pyr-bala-betahph 7801: impy-25thiaz-gly-zdap 7802: gua-24oxaz-gly-betafluo 5 7803: phhs-ithiadiaz-gly-betaheph 7804: bhs-42nmeim-leu-betadcph 7805: phhs-nme35pyr-bala-busu2be -237 7806: bim-thiadiaz-leu-psdap 7807: dhim-52thiaz-ala-zdap 7808: bhs-24thioph-gly-betahdbph 7809: nmhs-24oxaz-gly-betapy 5 7810: gua-42pym-gly-betahb 7811: tolhs-ithiadiaz-gly-betathiome 7812: 2py-24thioph-bala-aspbzla 7813: bhs-25oxaz-gly-betathiobe 7814: tolhs-me24oxaz-bala-psdap 0 7815: bhs-24thioph-gly-betahmph 7816: tolhs-nme35pyr-bala-csdap 7817: ibhs-25thiaz-gly-betamesu 7818: phhs-24thiaz-bala-ibsdap 7819: 2py-thiadiaz-gly-betadcph 5 7820: 2py-42oxaz-ala-betapy 7821: bhs-25thiaz-gly-psdapee 7822: bim-oxadiaz-ala-betadcph 7823: phhs-24thioph-bala-betadcphtb 7824: tolhs-25thiaz-gly-betampy 0 7825: ibhs-24thiaz-gly-betapych 7826: phhs-24thioph-gly-betamesu 7827: tolhs-me25thiaz-bala-psdap 7828: bim-25oxaz-bala-betadcph 7829: bhs-nme35pyr-gly-zdapch 5 7830: ibhs-25methiaz-gly-betaphethioa 7831: phhs-24thiaz-bala-aspaba 7832: tolhs-24thioph-bala-betahdbph 7833: bhs-me24thioph-leu-psdap 7834: phhs-25oxaz-gly-betathio3 0 7835: bhs-24thiaz-bala-beta4bph 7836: phhs-nme35pyr-gly-betatos 7837: ibhs-nme35pyr-bala-betaoxaz 7838: tolhs-24thioph-bala-betahbcph 7839: bhs-oxadiaz-gly-betahni 5 7840: phhs-25oxaz-bala-betaphethioa 7841: 2py-24thioph-bala-asppha 7842: tolhs-24thioph-gly-betaomebendi -238 7843: tolhs-25oxaz-bala-betabediox 7844: impy-24thioph-bala-betamesu 7845: ibhs-24thiaz-bala-betathiome 7846: 2py-42nmeim-ala-betapy 5 7847: ibhs-24thiaz-bala-betaphethio 7848: phhs-24thioph-bala-betafbph 7849: phhs-me25thioph-ala-psdap 7850: bhs-nme35pyr-gly-betamethi 7851: bim-me25thioph-bala-beta34meoph 0 7852: bhs-24thioph-gly-betapyr 7853: ibhs-oxadiaz-gly-betaoxaz 7854: bhs-me24thioph-gly-betaph 7855: bhs-53pyrazo-ala-psdap 7856: phhs-oxadiaz-bala-betabdimo 5 7857: bhs-24thiaz-gly-betadtrif 7858: bim-25oxaz-leu-betadcph 7859: ibhs-ithiadiaz-gly-betapym 7860: bhs-nme35pyr-bala-beta3quin 7861: bhs-ithiadiaz-bala-betabdimo 0 7862: ibhs-oxadiaz-bala-betahmph 7863: tolhs-25methiaz-gly-betahmo 7864: ibhs-25methiaz-gly-betamethi 7865: ibhs-25thiaz-gly-aspaba 7866: bhs-oxadiaz-bala-betadcphch 5 7867: ibhs-ithiadiaz-bala-betapych 7868: bhs-24thiaz-gly-betabmph 7869: ibhs-ithiadiaz-gly-csdap 7870: bhs-25oxaz-ala-betameph 7871: bhs-25oxaz-gly-psdapch 0 7872: bhs-25thiaz-bala-beta35dbph 7873: bim-nme35pyr-bala-betadcph 7874: phhs-oxadiaz-bala-betadcph 7875: bim-24oxaz-leu-zdap 7876: bhs-ithiadiaz-gly-betaphethioa 5 7877: bhs-24thiaz-gly-betatho3 7878: tolhs-24thiaz-bala-betampy 7879: bhs-24thiaz-gly-betadito -239 7880: bhs-me24thioph-bala-betaph 7881: 2py-24oxaz-ala-betainyl 7882: bhs-nme35pyr-bala-betabthioph 7883: phhs-25methiaz-bala-betathio3 5 7884: bhs-25thiaz-gly-betabph 7885: tolhs-25thiaz-gly-betadcph 7886: ibhs-24thioph-gly-betaimid 7887: ibhs-24thiaz-gly-betadcph 7888: ibhs-ithiadiaz-gly-psdapch 0 7889: tolhs-me25thiaz-ala-betaph 7890: thazep-42pym-gly-betadcph 7891: bhs-25thiaz-bala-betaol 7892: phhs-ithiadiaz-gly-psdapee 7893: bhs-24thioph-ala-betaipro 5 7894: bhs-24thioph-gly-betaftrif 7895: bhs-ithiadiaz-bala-betapych 7896: phhs-24thiaz-gly-betaamibe 7897: bhs-nme35pyr-gly-betaphethioa 7898: bim-25methiaz-gly-betaanaphth 0 7899: bim-thiadiaz-gly-zdap 7900: ibhs-25methiaz-gly-asppha 7901: toihs-24thiaz-bala-betaphethio 7902: ibhs-24thiaz-bala-psdapch 7903: tolhs-25thiaz-gly-betaanaphth 5 7904: bhs-25methiaz-bala-betadcphee 7905: tolhs-me24oxaz-bala-betadcph 7906: bhs-25methiaz-bala-psdap 7907: tolhs-nme35pyr-bala-betafph 7908: ibhs-oxadiaz-gly-zdaptb D 7909: bhs-oxadiaz-ala-betabpy 7910: bhs-nme35pyr-gly-betathiome 7911: 2py-42oxaz-gly-psdap 7912: bim-me24oxaz-gly-betapy 7913: tolhs-25oxaz-bala-betahb 5 7914: ibhs-ithiadiaz-gly-betah35dc 7915: phhs-25methiaz-bala-betapym 7916: bhs-ithiadiaz-gly-busu2be -240 7917: tolhs-ithiadiaz-bala-betacph 7918: tolhs-24thioph-bala-zdapee 7919: bhs-me25thiaz-leu-psdap 7920: gua-24thiaz-gly-betabnaphth 5 7921: bhs-oxadiaz-gly-betaipr 7922: bhs-me25thiaz-bala-beta34meoph 7923: bhs-25thiaz-bala-betamethioph 7924: tolhs-24thiaz-bala-betadito 7925: ibhs-ithiadiaz-bala-betacbph 0 7926: phhs-24thiaz-gly-betafbph 7927: phhs-24thioph-gly-betacph 7928: phhs-25methiaz-bala-betainyl 7929: ibhs-nme35pyr-gly-betabthioph 7930: tolhs-24thiaz-bala-betahph 5 7931: tolhs-25oxaz-gly-betahcbph 7932: tolhs-me24oxaz-bala-beta34meoph 7933: tolhs-me25oxaz-leu-betaph 7934: bhs-nme35pyr-gly-betafu2 7935: bhs-me25oxaz-gly-beta34meoph 0 7936: tolhs-25thiaz-bala-betapyee 7937: ibhs-nme35pyr-bala-betaanaphth 7938: bhs-oxadiaz-ala-betathio3 7939: 2py-25fur-ala-betapy 7940: tolhs-25oxaz-bala-csdap 5 7941: tolhs-nme35pyr-bala-aspibua 7942: 4pmhs-25methiaz-bala-betameph 7943: bhs-nme35pyr-ala-betabnaphth 7944: phhs-24thiaz-gly-betabmph 7945: tolhs-24thiaz-gly-betaoxaz 0 7946: ibhs-ithiadiaz-bala-betambiph 7947: impy-25methiaz-bala-betah35dc 7948: tolhs-25oxaz-gly-betaet 7949: phhs-oxadiaz-bala-betampy 7950: phhs-ithiadiaz-gly-betambiph 5 7951: bhs-nme35pyr-gly-betapytb 7952: phhs-ithiadiaz-bala-betabpy 7953: bim-25thioph-leu-zdap -241 7954: bhs-24thiaz-ala-betafphe 7955: ibhs-nme35pyr-bala-betafu2 7956: bhs-24thiaz-bala-zdapee 7957: phhs-24thiaz-bala-betacthioph 5 7958: bim-53pyrazo-leu-zdap 7959: ibhs-24thiaz-bala-zdapee 7960: bim-me25thioph-gly-zdap 7961: ibhs-oxadiaz-bala-betacthioph 7962: tolhs-me25thioph-bala-psdap 0 7963: phhs-25thiaz-gly-betafu3 7964: ibhs-24thiaz-bala-betabenfu 7965: tolhs-25thiaz-gly-betacbph 7966: bhs-24thiaz-gly-betafbph 7967: bim-35fur-leu-betadcph 5 7968: bim-25oxaz-bala-betahph 7969: phhs-24thiaz-gly-beta34dcph 7970: ibhs-nme35pyr-gly-beta23meoph 7971: phhs-24thiaz-bala-betamethioph 7972: ibhs-25thiaz-gly-beta3quin 0 7973: bim-25thioph-leu-psdap 7974: bhs-25thiaz-gly-psdaptb 7975: bhs-ithiadiaz-bala-betambiph 7976: bhs-24thiaz-bala-betabthioph 7977: bhs-24thiaz-gly-beta34meoph 5 7978: bhs-24thioph-bala-betambiph 7979: bhs-ithiadiaz-ala-psdap 7980: phhs-25thiaz-gly-betapych 7981: bhs-oxadiaz-bala-betaph 7982: 2py-42oxaz-bala-zdap 0 7983: bhs-oxadiaz-gly-betadcphch 7984: bhs-25thiaz-gly-betabmph 7985: bhs-25methiaz-gly-betafu3 7986: bhs-nme35pyr-gly-betahmofu 7987: ibhs-oxadiaz-bala-psdap 5 7988: 2py-me24thioph-ala-beta34meoph 7989: 2py-nme35pyr-bala-betadcph 7990: phhs-24thioph-bala-betathio3 -242 7991: 2py-35thioph-ala-betadcph 7992: phhs-24thioph-gly-betahcbph 7993: 2py-35fur-leu-betadcph 7994: ibhs-oxadiaz-bala-betadmph 5 7995: bhs-nme35pyr-gly-betaph 7996: ibhs-oxadiaz-bala-betapytb 7997: phhs-25thiaz-gly-zdap 7998: impy-25oxaz-gly-betahdbph 7999: bhs-me25oxaz-bala-betadcph 0 8000: bim-25fur-gly-zdap 8001: bhs-25oxaz-ala-betaipro 8002: bhs-24thioph-nmgly-betahmph 8003: tolhs-nme35pyr-gly-betamethi 8004: bhs-me25thiaz-ala-psdap 5 8005: gua-24thiaz-gly-betaphethioa 8006: bim-25methiaz-leu-betadcph 8007: ibhs-ithiadiaz-bala-csdap 8008: phhs-25oxaz-gly-aspaba 8009: tolhs-oxadiaz-gly-betathiome 0 8010: phhs-24thioph-gly-psdapee 8011: phhs-nme35pyr-gly-psdap 8012: bhs-25oxaz-nmgly-betameph 8013: tolhs-oxadiaz-gly-beta23meoph 8014: ibhs-24thiaz-bala-betathioph 5 8015: tolhs-24thiaz-gly-betaet 8016: bhs-25oxaz-ala-betacthioph 8017: tolhs-oxadiaz-gly-betahmofu 8018: phhs-24thioph-gly-betaet 8019: ibhs-25thiaz-bala-betabph 0 8020: tolhs-24thioph-bala-betampy 8021: bhs-25oxaz-gly-betahni 8022: bhs-25oxaz-gly-betahmofu 8023: bhs-me25thiaz-ala-betadcph 8024: pbhs-24thioph-bala-beta35dbph 5 8025: dhim-42pym-ala-psdap 8026: 2py-24thioph-gly-betatbuph 8027: bhs-oxadiaz-ala-betadcph -243 8028: 2py-35thioph-leu-zdap 8029: phhs-oxadiaz-gly-betaimid 8030: phhs-nme35pyr-gly-betacph 8031: ibhs-nme35pyr-bala-zdap 5 8032: gua-26py-gly-betadmph 8033: phhs-25thiaz-gly-betaoxope 8034: ibhs-oxadiaz-gly-betaamibe 8035: phhs-24thioph-gly-betapyee 8036: 2py-35thioph-gly-betapy 0 8037: bhs-35fur-ala-betapy 8038: bhs-24thiaz-nmgly-betamesu 8039: phhs-nme35pyr-gly-betaanaphth 8040: bgua-42pym-gly-betainyl 8041: ibhs-24thiaz-bala-betafphe 5 8042: bhs-25thiaz-ala-betathio3 8043: tolhs-24thiaz-bala-betacthioph 8044: bhs-25fur-leu-betapy 8045: phhs-24thiaz-gly-betafu3 8046: phhs-24thiaz-gly-betahdcph 0 8047: tolhs-25thiaz-gly-aspibua 8048: phhs-25oxaz-bala-betapyee 8049: ibhs-oxadiaz-gly-aspaba 8050: phhs-25methiaz-bala-betafbph 8051: bhs-25oxaz-nmgly-betadito 5 8052: bhs-oxadiaz-bala-betapyee 8053: agua-25oxaz-bala-betameph 8054: bim-me25thioph-bala-betadcph 8055: tolhs-24thiaz-bala-betahb 8056: tolhs-me24thiaz-gly-psdap 0 8057: bhs-24thiaz-bala-betaphethioa 8058: 2py-25thiaz-leu-zdap 8059: ibhs-oxadiaz-gly-betah35dc 8060: tolhs-24thiaz-gly-beta4bph 8061: bhs-25methiaz-gly-betaipr 5 8062: tolhs-ithiadiaz-gly-betaibph 8063: dhim-23thioph-gly-betameph 8064: bhs-24thioph-bala-zdaptb -244 8065: ibhs-25oxaz-gly-betaibph 8066: bhs-oxadiaz-nmgly-betacthioph 8067: bim-me25thioph-gly-betapy 8068: bhs-24thioph-gly-betahbcph 5 8069: bim-me24oxaz-gly-betaph 8070: impy-25oxaz-bala-betahmo 8071: ibhs-25methiaz-gly-beta23meoph 8072: 2py-ithiadiaz-bala-psdap 8073: phhs-24thiaz-gly-betatos 0 8074: bim-me24oxaz-leu-betaph 8075: 2py-26py-gly-psdap 8076: bhs-24thiaz-ala-betathio3 8077: bhs-25thiaz-bala-betatrif 8078: bim-24thiaz-gly-aspibua 5 8079: phhs-oxadiaz-bala-betathiome 8080: tolhs-24thioph-gly-betaibph 8081: phhs-24thiaz-bala-betaphethio 8082: tolhs-ithiadiaz-bala-betaph 8083: bhs-24thiaz-bala-betathiome 0 8084: bhs-me25thioph-gly-zdap 8085: phhs-nme35pyr-gly-betathiome 8086: tolhs-ithiadiaz-gly-zdapee 8087: phhs-25oxaz-bala-betaamibe 8088: bim-24oxaz-bala-psdap 5 8089: phhs-25oxaz-bala-aspbzla 8090: bim-42oxaz-gly-zdap 8092: ibhs-25thiaz-bala-betatos 8092: ibhs-oxadiaz-bala-aspaba 8093: phhs-nme35pyr-gly-betadcph D 8094: gua-24thiaz-gly-beta3quin 8095: 2py-25oxaz-gly-betathiobe 8096: tolhs-25methiaz-bala-betabnaphth 8097: bhs-25oxaz-ala-betacph 8098: bhs-nme35pyr-bala-betahcbph 5 8099: bim-me24thioph-ala-betaph 8100: ibhs-25methiaz-bala-ibsdap 8101: bhs-25methiaz-leu-zdap -245 8102: bhs-25thiaz-ala-betadhbfu 8103: bim-42oxaz-gly-psdap 8104: bhs-25thiaz-gly-betabiph 8105: gua-25thioph-gly-betaipr 5 8106: phhs-24thioph-gly-betapych 8107: bhs-25oxaz-gly-beta23meoph 8108: tolhs-24thioph-bala-asppha 8109: bhs-24thiaz-gly-betaipro 8110: tolhs-ithiadiaz-bala-betahdcph 0 8111: bim-24thiaz-ala-zdap 8112: tolhs-25thiaz-bala-beta34meoph 8113: bhs-ithiadiaz-gly-betaipro 8114: tolhs-25thiaz-gly-betapych 8115: tolhs-24thioph-bala-aspibua 5 8116: bhs-nme35pyr-gly-betafbph 8117: dhim-52thiaz-ala-betadcph 8118: 2py-35fur-ala-betadcph 8119: phhs-25thiaz-bala-zdap 8120: 2pmhs-25thiaz-gly-betahbcph 0 8121: bhs-25thiaz-bala-betahph 8122: bhs-oxadiaz-bala-betathiobe 8123: bhs-25methiaz-ala-betathioph 8124: tolhs-25oxaz-gly-aspaba 8125: 2py-24thiaz-gly-beta35dbph 5 8126: ibhs-ithiadiaz-gly-betahc 8127: bhs-oxadiaz-bala-betabdimo 8128: phhs-25oxaz-bala-betaphethio 8129: bhs-25oxaz-ala-betal 3bendi 8130: phhs-ithiadiaz-bala-beta23meoph 0 8131: bhs-25methiaz-gly-betafph 8132: tolhs-24thiaz-gly-betaol 8133: tolhs-oxadiaz-gly-betaipro 8134: tolhs-25methiaz-gly-aspbzla 8135: ibhs-oxadiaz-gly-betaanaphth 5 8136: tolhs-oxadiaz-bala-betaoxope 8137: bhs-25methiaz-nmgly-betacthioph 8138: 2pmhs-25thiaz-gly-betaph -246 8139: bhs-25oxaz-gly-betadcphch 8140: bim-25oxaz-bala-betabmph 8141: bhs-nme35pyr-gly-betafphe 8142: bhs-ithiadiaz-bala-betatos 5 8143: phhs-24thiaz-gly-betamethi 8144: thpym-24oxaz-gly-zdap 8145: tolhs-me25thiaz-bala-beta34meoph 8146: tolhs-nme35pyr-bala-betaimid 8147: bhs-nme35pyr-ala-betainyl 0 8148: bhs-25oxaz-gly-betatbuph 8149: 2py-42pym-ala-betadcph 8150: tolhs-24thioph-gly-betafph 8151: bim-me25oxaz-bala-betapy 8152: bim-25methiaz-bala-aspbzla 5 8153: 2py-me25thiaz-ala-zdap 8154: tolhs-25thiaz-gly-psdaptb 8155: 2py-52thiaz-ala-betadcph 8156: bhs-25oxaz-bala-betah35dc 8157: gua-24oxaz-gly-betaipro 0 8158: tolhs-me25thioph-ala-psdap 8159: gua-24thiaz-gly-betamethi 8160: bhs-nme35pyr-leu-betadcph 8161: bim-oxadiaz-gly-betapy 8162: bhs-35fur-ala-psdap 5 8163: bhs-25methiaz-gly-betapy 8164: ibhs-24thiaz-bala-betal 3bendi 8165: tolhs-24thiaz-bala-beta3quin 8166: bhs-ithiadiaz-bala-betatrif 8167: bhs-ithiadiaz-gly-betahmph 8168: tolhs-ithiadiaz-gly-betaheph 8169: tolhs-24thioph-gly-betampy 8170: tolhs-25oxaz-gly-betathiome 8171: ibhs-nme35pyr-gly-betahdcph 8172: ibhs-oxadiaz-bala-betabediox i 8173: phhs-25methiaz-bala-betadhbfu 8174: bhs-25methiaz-gly-betabnaphth 8175: bhs-ithiadiaz-bala-betacph -247 8176: bhs-24thioph-bala-betadmph 8177: tolhs-nme35pyr-bala-betafu3 8178: phhs-25methiaz-gly-betahni 8179: ibhs-25methiaz-bala-betaphethioa 5 8180: tolhs-nme35pyr-bala-betamethioph 8181: tolhs-ithiadiaz-bala-betaphethio 8182: tolhs-25methiaz-gly-betaipro 8183: ibhs-24thiaz-gly-betaanaphth 8184: bhs-nme35pyr-bala-betabediox 0 8185: 2pmhs-42nmeim-bala-betapym 8186: ibhs-25oxaz-gly-betaipro 8187: phhs-24thioph-gly-psdap 8188: bhs-25oxaz-nmgly-betathio3 8189: bhs-24thioph-bala-betadtrif 5 8190: tolhs-ithiadiaz-bala-betamethi 8191: tolhs-25methiaz-bala-betabenfu 8192: ibhs-24thioph-bala-betadmoph 8193: tolhs-25oxaz-gly-betahb 8194: tolhs-me24thiaz-gly-zdap 0 8195: phhs-oxadiaz-gly-betathioph 8196: bhs-25thiaz-gly-betafphe 8197: ibhs-24thioph-bala-betaipr 8198: gua-25thioph-gly-betapyr 8199: phhs-nme35pyr-gly-betameph 5 8200: ibhs-25oxaz-gly-zdap 8201: ibhs-25methiaz-gly-zdap 8202: bhs-24thiaz-ala-betainyl 8203: bhs-nme35pyr-bala-betathiome 8204: bhs-24thiaz-bala-betathiobe 0 8205: tolhs-24thiaz-bala-betapym 8206: tolhs-25methiaz-gly-betathioph 8207: tolhs-ithiadiaz-bala-betapym 8208: tolhs-25oxaz-bala-betaimid 8209: tolhs-ithiadiaz-bala-betaipro 5 8210: bhs-25thiaz-bala-beta1 3bendi 8211: 2pmhs-24thioph-gly-betabpy 8212: ibhs-ithiadiaz-bala-betadcph -248 8213: bhs-24thiaz-gly-betabnaphth 8214: bhs-25oxaz-bala-betahmno 8215: 2py-me24oxaz-leu-betaph 8216: tolhs-25methiaz-gly-betahph 5 8217: phhs-25oxaz-gly-betapyr 8218: bhs-25oxaz-nmgly-betafphe 8219: bim-25thiaz-gly-betameph 8220: bhs-oxadiaz-bala-aspbzla 8221: bim-25oxaz-gly-betahb 0 8222: phhs-me25thiaz-ala-zdap 8223: tolhs-me24oxaz-bala-betapy 8224: gua-24thiaz-gly-betahbcph 8225: bim-24oxaz-ala-betainyl 8226: 2pmhs-25oxaz-gly-betathio3 5 8227: bhs-25oxaz-bala-betadcphtb 8228: 2py-me24oxaz-gly-betaph 8229: bhs-24thiaz-nmgly-beta34dcph 8230: ibhs-nme35pyr-bala-betal 3bendi 8231: bhs-me24thiaz-gly-psdap 0 8232: ibhs-nme35pyr-bala-betadtrif 8233: tolhs-nme35pyr-bala-betaoxope 8234: 2py-25fur-leu-betapy . 8235: tolhs-nme35pyr-bala-betahc 8236: 2py-me24thiaz-ala-psdap 5 8237: bim-me24thiaz-ala-betapy 8238: tolhs-25thiaz-gly-betabthioph 8239: 2py-25thioph-bala-psdap 8240: ibhs-25thiaz-gly-betahdcph 8241: bim-26py-gly-psdap 0 8242: 2py-35fur-gly-betapy 8243: phhs-25methiaz-bala-betabph 8244: phhs-25thiaz-bala-betahbcph 8245: ibhs-24thioph-gly-betadcphtb 8246: 2py-me25thiaz-leu-betaph 5 8247: ibhs-25thiaz-gly-betaipr 8248: ibhs-24thioph-gly-betacbph 8249: ibhs-25methiaz-bala-betaamibe -249 8250: phhs-25methiaz-gly-betapyee 8251: bhs-24thioph-bala-betahdbph 8252: bhs-24thiaz-gly-aspbzla 8253: phhs-25methiaz-bala-betadcphch 5 8254: bhs-nme35pyr-gly-betabph 8255: bim-42nmeim-bala-betambiph 8256: bhs-25thiaz-gly-betaet 8257: ibhs-nme35pyr-gly-betaamibe 8258: ibhs-oxadiaz-bala-betahmo 10 8259: tolhs-oxadiaz-bala-asppha 8260: ibhs-nme35pyr-bala-betacph 8261: phhs-ithiadiaz-bala-betabthioph 8262: bhs-25thiaz-gly-betafph 8263: hyd-25thioph-gly-zdap 15 8264: phhs-24thiaz-bala-betahmph 8265: ibhs-nme35pyr-gly-betabnaphth 8266: tolhs-me25oxaz-bala-betaph 8267: impy-24thioph-gly-betabediox 8268: tolhs-me25oxaz-leu-betadcph 20 8269: tolhs-oxadiaz-gly-betadmoph 8270: bhs-26py-gly-betaph 8271: bhs-24thioph-gly-asppha 8272: bhs-25oxaz-gly-betacph 8273: bhs-24thiaz-bala-betapbiph 25 8274: ibhs-nme35pyr-gly-betaph 8275: phhs-25thiaz-bala-beta3quin 8276: dhim-42pym-gly-betameph 8277: 2py-25methiaz-bala-beta34dcph 8278: tolhs-25methiaz-gly-betaphethioa 30 8279: bhs-24thioph-bala-betathio3 8280: bim-24thioph-bala-betampy 8281: phhs-24thiaz-gly-betabph 8282: bim-24thiaz-bala-betaimid 8283: tolhs-me25thiaz-bala-betaph 35 8284: phhs-24thioph-gly-zdapee 8285: phhs-24thioph-bala-betadcph 8286: tolhs-ithiadiaz-gly-betampy -250 8287: bhs-25methiaz-gly-csdap 8288: bhs-42nmeim-ala-psdap 8289: phhs-oxadiaz-gly-betabmph 8290: tolhs-oxadiaz-gly-betaheph 5 8291: bhs-oxadiaz-ala-betapy 8292: ibhs-oxadiaz-bala-betahni 8293: ibhs-24thioph-bala-betaph 8294: phhs-25oxaz-bala-psdap 8295: tolhs-me25thioph-leu-betadcph 0 8296: phhs-25thiaz-bala-betahni 8297: phhs-nme35pyr-bala-beta34meoph 8298: phhs-nme35pyr-bala-betafphe 8299: 2py-25thiaz-bala-betaoxope 8300: tolhs-ithiadiaz-bala-psdapee 5 8301: tolhs-25methiaz-gly-betapbiph 8302: ibhs-ithiadiaz-bala-betabmph 8303: bim-24thiaz-gly-aspbzla 8304: phhs-oxadiaz-bala-betabthioph 8305: bhs-25fur-leu-psdap 0 8306: bhs-nme35pyr-gly-betadcphch 8307: 2py-oxadiaz-leu-zdap 8308: tolhs-24thioph-bala-betadmph 8309: 2pmhs-25methiaz-phe-zdap 8310: phhs-25methiaz-bala-betapyee 5 8311: bhs-25methiaz-ala-betameph 8312: phhs-me24oxaz-leu-psdap 8313: 2pmhs-42nmeim-bala-betampy 8314: bhs-ithiadiaz-gly-betaoxaz 8315: tolhs-me25thiaz-leu-betadcph 0 8316: tolbs-24thioph-bala-betahmofu 8317: bim-24thiaz-gly-betapbiph 8318: tolhs-me24thiaz-ala-beta34meoph 8319: bhs-24thioph-nmgly-betafphe 8320: ibhs-24thioph-bala-aspaba 5 8321: bhs-ithiadiaz-nmgly-betadmph 8322: tolhs-25thiaz-gly-betaimid 8323: bhs-24thiaz-ala-beta34meoph -251 8324: tolhs-25thiaz-bala-betafu3 8325: phhs-25methiaz-gly-betapy 8326: tolhs-25methiaz-gly-betadcphee 8327: tolhs-25methiaz-gly-betafu2 5 8328: phhs-24thiaz-bala-betahni 8329: bhs-25oxaz-gly-beta34dcph 8330: ibhs-25methiaz-bala-betacph 8331: phhs-24thioph-gly-aspaba 8332: bhs-53pyrazo-ala-zdap 0 8333: bhs-ithiadiaz-bala-psdaptb 8334: ibhs-oxadiaz-bala-psdapee 8335: bhs-nme35pyr-gly-ibsdap 8336: bhs-52thiaz-ala-betameph 8337: bhs-nme35pyr-mugly-betadito 5 8338: phhs-24thioph-bala-betadhbfu 8339: phhs-25oxaz-bala-betaanaphth 8340: bhs-nme35pyr-gly-betacthioph 8341: bhs-25methiaz-gly-betadmoph 8342: tolhs-24thioph-gly-betabph 0 8343: phhs-24thiaz-gly-zdap 8344: bhs-25oxaz-gly-betadbph 8345: tolhs-ithiadiaz-bala-betameph 8346: phhs-25oxaz-gly-betapy 8347: bhs-25methiaz-bala-betadhbfu 5 8348: bim-25oxaz-leu-zdap 8349: bhs-ithiadiaz-gly-csdap 8350: tolhs-24thiaz-gly-zdaptb 8351: ibhs-nme35pyr-bala-betaph 8352: ibhs-25thiaz-bala-betapyr 0 8353: ibhs-24thiaz-gly-betahmo 8354: ur-25thiaz-gly-betadcph 8355: ibhs-25methiaz-bala-betabnaphth 8356: tolhs-24thiaz-gly-asppha 8357: bhs-24thiaz-nmgly-betaoxaz 5 8358: ibhs-25methiaz-gly-betacph 8359: bhs-25oxaz-ala-psdap 8360: bim-ithiadiaz-bala-asppha -252 8361: dhim-26py-gly-betambiph 8362: phhs-25oxaz-gly-beta34meoph 8363: 2py-ithiadiaz-ala-zdap 8364: 2pmhs-42nmeim-bala-betadhbfu 5 8365: phhs-nme35pyr-gly-betabpy 8366: ibhs-ithiadiaz-gly-betadhbfu 8367: bhs-25methiaz-bala-betamethi 8368: tolhs-oxadiaz-bala-betafluo 8369: phhs-25oxaz-gly-betapyee 0 8370: phhs-25thiaz-bala-betapyee 8371: ibhs-oxadiaz-gly-betacph 8372: bim-53pyrazo-bala-betapy 8373: phhs-25oxaz-bala-betabph 8374: bhs-24thioph-bala-betaphethio 5 8375: 2py-me25oxaz-ala-betaph 8376: tolhs-nme35pyr-gly-betatos 8377: ibhs-nme35pyr-bala-betaoxope 8378: tolhs-25thiaz-bala-betabpy 8379: gua-25tbiaz-gly-betabnaphth 0 8380: bhs-24thioph-nmgly-beta34meoph 8381: impy-42nmeim-bala-betaph 8382: ibhs-24thioph-gly-betapy 8383: tolhs-25thiaz-gly-betacthioph 8384: tolhs-25thiaz-gly-betabnaphth 5 8385: bhs-24thioph-gly-betafphe 8386: tolhs-oxadiaz-bala-betadcph 8387: bim-25thiaz-gly-betaanaphth 8388: 2py-ithiadiaz-bala-betadcph 8389: dhim-53pyrazo-gly-betameph 0 8390: ibhs-25thiaz-gly-beta34dcph 8391: tolhs-25thiaz-bala-beta3quin 8392: bhs-24thioph-bala-betadito 8393: gua-24oxaz-gly-betabph 8394: 2py-triaz-ala-betadcph 5 8395: bhs-25oxaz-bala-psdapch 8396: bhs-nme35pyr-nmgly-betameph 8397: phbs-25oxaz-bala-betah35dc -253 8398: impy-24thiaz-bala-betamesu 8399: 2pmhs-25oxaz-bala-betaheph 8400: bhs-25oxaz-bala-beta23meoph 8401: impy-25oxaz-bala-betahdcph 5 8402: 2py-me25oxaz-gly-zdap 8403: phhs-24thiaz-bala-betacph 8404: phhs-oxadiaz-bala-betacph 8405: tolhs-nme35pyr-bala-betapych 8406: tolhs-25oxaz-bala-betamethioph 0 8407: bhs-ithiadiaz-gly-beta34dcph 8408: tolhs-me25thioph-leu-zdap 8409: ibhs-25thiaz-bala-betadmoph 8410: phhs-25thiaz-bala-zdapee 8411: bhs-oxadiaz-gly-betatbuph 5 8412: bhs-42nmeim-bala-betatbuph 8413: 2py-42nmeim-bala-betadmph 8414: phhs-25oxaz-bala-betaoxaz 8415: 2py-24oxaz-gly-betameph 8416: tolhs-ithiadiaz-bala-betabenfu D 8417: 2py-42nmeim-phg-betadcph 8418: ibhs-24thiaz-gly-betahc 8419: phhs-25thiaz-gly-betabediox 8420: tolhs-24thioph-bala-betatrif 8421: bhs-25fur-bala-psdap 5 8422: ibhs-25thiaz-bala-betaibph 8423: tolhs-nme35pyr-bala-psdapch 8424: tolhs-24thioph-gly-betaph 8425: bhs-ithiadiaz-gly-betabnaphth 8426: bim-25methiaz-ala-zdap 8427: ibhs-ithiadiaz-gly-betafluo 8428: bhs-25thiaz-bala-betafu2 8429: phhs-nme35pyr-gly-csdap 8430: thpym-24oxaz-gly-betahdcph 8431: bim-25thioph-gly-betadcph 5 8432: bhs-25oxaz-bala-betadmoph 8433: bhs-24thioph-gly-psdaptb 8434: bim-me24oxaz-ala-psdap -254 8435: gua-26py-gly-betadcph 8436: bhs-ithiadiaz-bala-betapytb 8437: phhs-25methiaz-gly-betadito 8438: impy-24thiaz-bala-betah35dc 5 8439: ibhs-24thiaz-bala-betapyr 8440: bhs-25thiaz-gly-betameph 8441: tolhs-25oxaz-gly-betabenfu 8442: 2py-25thiaz-leu-betadcph 8443: bhs-24thiaz-gly-betacbph 0 8444: bhs-25thiaz-bala-busu2be 8445: bhs-oxadiaz-gly-betaimid 8446: ibhs-oxadiaz-gly-betaftrif 8447: bhs-ithiadiaz-bala-betah35dc 8448: bhs-25methiaz-bala-betaftrif 5 8449: phhs-24thiaz-gly-betahmph 8450: tolhs-me25thiaz-gly-betadcph 8451: phhs-me24thiaz-bala-psdap 8452: 2py-me24thioph-ala-betadcph 8453: bhs-24thioph-bala-betadmoph 0 8454: ibhs-25thiaz-gly-betapym 8455: phhs-24thiaz-gly-betaoxaz 8456: 2py-25thiaz-bala-asppha 8457: bhs-me25thioph-leu-betadcph 8458: phhs-24thiaz-gly-betabpy 5 8459: bim-25oxaz-gly-betapy 8460: phhs-24thioph-gly-betapytb 8461: ibhs-ithiadiaz-gly-betatrif 8462: bhs-24thiaz-bala-csdap 8463: phhs-ithiadiaz-bala-zdapee 0 8464: 2py-25fur-ala-psdap 8465: tolhs-me25oxaz-bala-betapy 8466: ibhs-nme35pyr-bala-betadito 8467: 2pmhs-24thioph-gly-betahb 8468: thpym-24thiaz-gly-betahcbph 5 8469: ibhs-ithiadiaz-gly-betahcbph 8470: ibhs-oxadiaz-gly-betapyr 8471: ibhs-25oxaz-gly-betafph -255 8472: phhs-24thioph-gly-psdaptb 8473: bhs-25oxaz-gly-betafu2 8474: ibhs-25methiaz-gly-betadcphtb 8475: dhim-24thiaz-gly-psdap 5 8476: bhs-ithiadiaz-bala-betafu2 8477: tolhs-25methiaz-bala-betameph 8478: phhs-25thiaz-bala-betafu2 8479: gua-24oxaz-gly-busu2be 8480: phhs-nme35pyr-bala-betahc 0 8481: phhs-24thiaz-gly-betahc 8482: phhs-25oxaz-gly-asppha 8483: phhs-nme35pyr-gly-betafu2 8484: ibhs-24thioph-bala-betabmph 8485: phhs-ithiadiaz-gly-betaol 5 8486: bhs-25methiaz-nmgly-betadhbfu 8487: tolhs-24thioph-gly-betaanaphth 8488: tolhs-24thiaz-bala-betameph 8489: phhs-25thiaz-bala-betamesu 8490: tolhs-25methiaz-gly-asppha 0 8491: ibhs-ithiadiaz-bala-betabpy 8492: bhs-25thiaz-gly-betahb 8493: phhs-25oxaz-bala-betambiph 8494: bim-35fur-ala-betadcph 8495: bhs-oxadiaz-bala-betacbph 5 8496: bhs-nme35pyr-bala-betadcphtb 8497: bhs-26py-gly-betadcph 8498: ibhs-25thiaz-bala-betafu3 8499: phhs-24thiaz-gly-suabu 8500: bim-24oxaz-ala-betadcph 0 8501: bhs-oxadiaz-nmgly-betafphe 8502: bhs-24thioph-bala-betampy 8503: bim-25methiaz-bala-zdap 8504: tolhs-oxadiaz-gly-betaibph 8505: 2py-me24thiaz-gly-psdap 5 8506: thpym-42nmeim-bala-betapy 8507: bhs-25oxaz-bala-betahni 8508: 2py-oxadiaz-leu-betadcph -256 8509: ibhs-oxadiaz-bala-zdapee 8510: gua-42nmeim-bala-psdap 8511: gua-25thioph-gly-beta35dbph 8512: bhs-25oxaz-gly-betafph 5 8513: ibhs-nme35pyr-gly-betahni 8514: ibhs-ithiadiaz-bala-betafu2 8515: phhs-25oxaz-bala-betadmoph 8516: bim-triaz-leu-betapy 8517: 2py-24oxaz-gly-betadcph 0 8518: tolhs-25thiaz-gly-betapy 8519: tolhs-ithiadiaz-gly-csdap 8520: tolhs-25thiaz-bala-betathio3 8521: 2py-25oxaz-gly-betabediox 8522: ibhs-ithiadiaz-bala-betathio3 5 8523: tolhs-ithiadiaz-bala-beta3quin 8524: agua-25thiaz-gly-psdap 8525: ibhs-ithiadiaz-gly-betameph 8526: pbhs-me25oxaz-ala-zdap 8527: 2pmhs-24thiaz-bala-zdap 0 8528: bim-oxadiaz-bala-aspbzla 8529: bhs-25thiaz-ala-betathioph 8530: bhs-nme35pyr-bala-beta4bph 8531: phhs-me25thiaz-bala-beta34meoph 8532: bhs-24thioph-gly-betapych 5 8533: gua-24oxaz-gly-betadito 8534: tolhs-me25thioph-gly-betaph 8535: impy-25methiaz-gly-beta34meoph 8536: phhs-ithiadiaz-gly-betacbph 8537: ibhs-nme35pyr-bala-betaftrif 0 8538: 2py-25thioph-leu-psdap 8539: phhs-25oxaz-bala-betatos 8540: dhim-24thioph-gly-betapy 8541: tolhs-24thioph-bala-betabdimo 8542: bhs-42nmeim-bala-betathio3 5 8543: bhs-42nmeim-ala-zdap 8544: phhs-nme35pyr-bala-betabpy 8545: ibhs-nme35pyr-gly-betacbph -257 8546: bhs-25methiaz-bala-betadcphtb 8547: tolhs-me24oxaz-gly-beta34meoph 8548: tolhs-25oxaz-bala-betaftrif 8549: 3pmhs-24thiaz-gly-betapy 5 8550: bhs-24thioph-bala-betaamibe 8551: bim-24thioph-bala-zdap 8552: ibhs-24thiaz-gly-beta3quin 8553: tolhs-nme35pyr-gly-betafluo 8554: gua-26py-gly-betatrif 0 8555: phhs-me24thiaz-leu-betadcph 8556: 2pmhs-42nmeim-gly-betabdimo 8557: bim-52thiaz-gly-betapy 8558: phhs-25thiaz-gly-csdap 8559: phhs-25oxaz-gly-betahcbph 5 8560: phhs-oxadiaz-bala-betambiph 8561: ibhs-25oxaz-bala-ibsdap 8562: tolhs-24thioph-gly-betaipro 8563: bhs-24thiaz-bala-betaanaphth 8564: tolhs-25methiaz-gly-betatos 0 8565: tolhs-ithiadiaz-bala-betatbuph 8566: bhs-oxadiaz-gly-suabu 8567: 2pmhs-42nmeim-gly-betafbph 8568: 2py-me24thioph-bala-zdap 8569: phhs-nme35pyr-bala-suabu 5 8570: phhs-24thiaz-bala-betahcbph 8571: phhs-25thiaz-bala-betapych 8572: ibhs-24thioph-gly-psdapch 8573: ibhs-24thiaz-gly-betaphethioa 8574: tolhs-25methiaz-bala-betadtrif 0 8575: ibhs-ithiadiaz-bala-zdap 8576: bhs-24thioph-bala-betacph 8577: bhs-nme35pyr-gly-betathioph 8578: nmhs-25thioph-gly-betameph 8579: bhs-ithiadiaz-bala-betaheph 5 8580: ibhs-oxadiaz-gly-betamethioph 8581: phhs-24thioph-gly-betathiobe 8582: bhs-oxadiaz-gly-psdapch -258 8583: bim-26py-ala-betameph 8584: tolhs-25oxaz-gly-betaamibe 8585: phhs-24thioph-bala-betal 3bendi 8586: phhs-25methiaz-bala-betadbph 5 8587: 2pmhs-25oxaz-bala-betahni 8588: ibhs-24thioph-gly-aspibua 8589: dhim-25thioph-gly-psdap 8590: phhs-25oxaz-gly-betaipro 8591: bhs-25methiaz-gly-beta34meoph 0 8592: bhs-me25thioph-leu-betaph 8593: 2py-25oxaz-bala-betah35dc 8594: 2pmhs-24thioph-gly-betadtrif 8595: phhs-nme35pyr-bala-psdapch 8596: tolhs-25methiaz-gly-betadito 5 8597: ibhs-25oxaz-gly-beta34meoph 8598: bhs-25oxaz-bala-betaoxope 8599: phhs-nme35pyr-gly-betadcphch 8600: bhs-24thioph-gly-betathioph 8601: phhs-25thiaz-gly-betaphethioa 0 8602: phhs-25thiaz-gly-betambiph 8603: tolhs-ithiadiaz-gly-betafph 8604: bhs-nme35pyr-bala-betaph 8605: ibhs-25oxaz-gly-betapytb 8606: bim-24thiaz-gly-aspaba 5 8607: gua-26py-gly-busu2be 8608: bhs-25oxaz-ala-beta34meoph 8609: phhs-nme35pyr-bala-betapyr 8610: phias-ithiadiaz-gly-beta35dbph 8611: tolhs-me24oxaz-leu-betadcph 0 8612: bhs-24thiaz-gly-betahph 8613: phhs-25oxaz-gly-csdap 8614: tolhs-25thiaz-gly-betatos 8615: tolhs-25methiaz-gly-beta23meoph 8616: tolhs-24thiaz-bala-asppha 5 8617: ibhs-ithiadiaz-gly-psdaptb 8618: bhs-me24thiaz-bala-betapy 8619: phhs-25methiaz-bala-betahc -259 8620: ibhs-24thioph-bala-betamesu 8621: bhs-25oxaz-gly-csdap 8622: ibhs-nme35pyr-gly-psdapee 8623: ibhs-25methiaz-gly-betafu3 5 8624: 2py-me24thiaz-ala-betadcph 8625: bhs-25thiaz-bala-betabdimo 8626: phhs-nme35pyr-bala-betapych 8627: phhs-me24thiaz-ala-betapy 8628: bhs-25thiaz-gly-betaanaphth 0 8629: phhs-ithiadiaz-gly-betadcph 8630: bhs-25oxaz-gly-betapyr 8631: phhs-nme35pyr-gly-betaphethio 8632: phhs-25oxaz-gly-betameph 8633: ibhs-25oxaz-gly-betabenfu 5 8634: phhs-24thiaz-bala-betapyr 8635: tolhs-ithiadiaz-gly-betadbph 8636: ibhs-24thiaz-gly-betaoxaz 8637: bhs-25thiaz-gly-betampy 8638: phhs-24thiaz-bala-betadtrif 0 8639: bhs-24thioph-gly-busu2be 8640: tolhs-ithiadiaz-gly-beta3quin 8641: tolhs-ithiadiaz-bala-betapyee 8642: gua-25thiaz-bala-betadcph 8643: tolhs-oxadiaz-gly-betapytb 5 8644: ibhs-24thiaz-gly-betahbcph 8645: ibhs-25methiaz-gly-betadbph 8646: 2py-24thioph-gly-aspaba 8647: ibhs-25thiaz-gly-betahni 8648: ibhs-oxadiaz-bala-betacph 3 8649: bhs-25thiaz-gly-betacbph 8650: 2py-42oxaz-leu-psdap 8651: bhs-nme35pyr-gly-betahcbph 8652: tolhs-25thiaz-bala-betambiph 8653: phhs-oxadiaz-gly-betapych 5 8654: bhs-25methiaz-bala-betadcph 8655: tolhs-ithiadiaz-gly-betatos 8656: bhs-me25oxaz-gly-betadcph -260 8657: phhs-oxadiaz-gly-zdapch 8658: tolhs-oxadiaz-bala-betafbph 8659: bim-me25thioph-gly-psdap 8660: 2py-24thioph-bala-suabu 5 8661: 2pmhs-24thioph-phe-zdap 8662: bim-24oxaz-leu-betapy 8663: bhs-25oxaz-bala-betapbiph 8664: ibhs-25methiaz-gly-betafph 8665: phhs-25thiaz-gly-betathioph 0 8666: tolhs-24thioph-gly-betatbuph 8667: gua-26py-gly-betaibph 8668: ibhs-24thiaz-bala-betabmph 8669: phhs-ithiadiaz-gly-psdaptb 8670: phhs-nme35pyr-gly-beta23meoph 5 8671: bhs-25thiaz-bala-betampy 8672: ibhs-25thiaz-bala-psdapee 8673: 2pmhs-25thiaz-bala-betahph 8674: 2py-53pyrazo-bala-psdap 8675: bhs-oxadiaz-gly-betabnaphth 0 8676: 2py-42oxaz-bala-psdap 8677: bim-24thioph-phg-zdap 8678: tolhs-25thiaz-gly-betahmo 8679: bhs-24thiaz-nmgly-betadmoph 8680: phhs-nme35pyr-gly-betaet 5 8681: phhs-24thioph-bala-betapyee 8682: phhs-ithiadiaz-gly-beta34meoph 8683: bhs-42py-ala-zdap 8684: bhs-24oxaz-ala-psdap 8685: impy-42nmeim-gly-beta4bph 0 8686: 2py-25thiaz-ala-betapy 8687: bim-me24oxaz-gly-psdap 8688: bhs-24thioph-gly-betabdimo 8689: tolhs-nme35pyr-bala-ibsdap 8690: gua-25thiaz-gly-betathiobe 5 8691: phhs-24thiaz-bala-beta35dbph 8692: 3pmhs-25oxaz-gly-betadcph 8693: phhs-24thioph-gly-betaheph -261 8694: dhim-26py-leu-zdap 8695: phhs-24thioph-gly-betathiome 8696: bhs-35thioph-ala-zdap 8697: bim-42oxaz-gly-betadcph 5 8698: phhs-25methiaz-gly-betafph 8699: bhs-ithiadiaz-bala-betaphethio 8700: phhs-nme35pyr-bala-betamethioph 8701: phhs-25thiaz-gly-betabph 8702: ibhs-24thioph-gly-betafluo 0 8703: bhs-25methiaz-bala-zdapee 8704: phhs-ithiadiaz-gly-betahmofu 8705: bhs-24thioph-gly-betathio3 8706: bhs-25thioph-bala-zdap 8707: phhs-24thioph-bala-betapytb 5 8708: phhs-24thiaz-bala-betatos 8709: phhs-nme35pyr-bala-betahb 8710: bhs-24thiaz-gly-betaomebendi 8711: phhs-nme35pyr-bala-betal 3bendi 8712: tolhs-25methiaz-bala-betafu3 0 8713: bhs-thiadiaz-bala-betadcph 8714: phhs-25thiaz-bala-betathiobe 8715: tolhs-me25thiaz-bala-betapy 8716: phhs-oxadiaz-gly-betadhbf u 8717: tolhs-oxadiaz-bala-betah35dc 5 8718: bim-24thioph-bala-betacph 8719: bim-me25oxaz-gly-zdap 8720: tolhs-me25thiaz-ala-beta34meoph 8721: ibhs-24thiaz-gly-zdapch 8722: bhs-ithiadiaz-gly-betahdbph 0 8723: bhs-24thioph-gly-betaamibe 8724: bhs-25oxaz-gly-betabdimo 8725: 2py-me25oxaz-gly-psdap 8726: gua-25thiaz-gly-betabediox 8727: phhs-24thioph-bala-suabu 5 8728: bhs-24thioph-ala-betadmoph 8729: 2py-nme35pyr-leu-zdap 8730: tolhs-ithiadiaz-bala-busu2be -262 8731: tolhs-nme35pyr-gly-betahph 8732: 2py-25oxaz-gly-psdap 8733: ibhs-25methiaz-gly-betafluo 8734: bhs-25thiaz-bala-betabediox 5 8735: impy-25thiaz-gly-betabthioph 8736: bhs-24thiaz-ala-betahph 8737: tolhs-me25thioph-bala-beta34meoph 8738: gua-26py-gly-betathioph 8739: ibhs-24thioph-bala-betabnaphth 0 8740: tolhs-24thiaz-gly-betahmo 8741: tolhs-ithiadiaz-gly-beta23meoph 8742: phhs-25methiaz-bala-betafu3 8743: phhs-24thioph-bala-betaomebendi 8744: bim-24thiaz-bala-betaipro 5 8745: tolhs-me24oxaz-ala-betapy 8746: 2pmhs-25thiaz-gly-betafph 8747: ibhs-oxadiaz-bala-betabenfu 8748: bim-25methiaz-gly-betadbph 8749: phhs-25methiaz-bala-betabediox 0 8750: tolhs-ithiadiaz-gly-betahdcph 8751: bhs-25thiaz-leu-betadcph 8752: phhs-oxadiaz-bala-zdaptb 8753: phhs-ithiadiaz-bala-betadtrif 8754: bhs-42oxaz-leu-psdap 5 8755: phhs-oxadiaz-gly-betaanaphth 8756: ibhs-25thiaz-gly-betathio3 8757: bhs-24thiaz-bala-psdapee 8758: bhs-25oxaz-bala-betaimid 8759: phhs-25thiaz-bala-betadcphtb 0 8760: 2py-triaz-bala-psdap 8761: tolhs-25methiaz-gly-betahcbph 8762: bhs-ithiadiaz-bala-betameph 8763: bim-24thioph-ala-betapy 8764: bhs-25oxaz-gly-betaphethioa 5 8765: bim-24thiaz-gly-betahmph 8766: phhs-25methiaz-gly-betadcphch 8767: ibhs-24thioph-bala-betafluo -263 8768: tolhs-24thiaz-gly-betapym 8769: bhs-24thioph-gly-betahcbph 8770: ibhs-nme35pyr-gly-betahc 8771: 2py-me25thioph-ala-betapy 5 8772: 2py-53pyrazo-bala-zdap 8773: ibhs-oxadiaz-bala-betafu2 8774: ibhs-25oxaz-gly-zdapee 8775: phhs-25thiaz-gly-betapytb 8776: ibhs-25oxaz-bala-beta34dcph 0 8777: tolhs-25oxaz-bala-betaphethio 8778: bhs-oxadiaz-bala-psdapee 8779: tolhs-oxadiaz-gly-betahdbph 8780: 2py-25methiaz-gly-betapy 8781: ibhs-24thiaz-gly-betahcbph 5 8782: bhs-25methiaz-gly-betafbph 8783: phhs-24thiaz-gly-betahb 8784: 2pmhs-24thioph-bala-zdap 8785: phhs-24thiaz-bala-betabdimo 8786: tolhs-nme35pyr-bala-betaoxaz D 8787: hts-25methiaz-gly-betapy 8788: phhs-me25thioph-bala-beta34meoph 8789: bhs-24thiaz-gly-betadhbfu 8790: gua-25thioph-gly-betafu3 8791: 2pmhs-24thiaz-bala-betal 3bendi 5 8792: bhs-oxadiaz-gly-beta4bph 8793: ibhs-24thiaz-gly-betal 3bendi 8794: ibhs-25methiaz-gly-betaoxaz 8795: tolhs-oxadiaz-gly-betal 3bendi 8796: ibhs-24thiaz-bala-busu2be 8797: bim-me24thiaz-ala-beta34meoph 8798: phhs-ithiadiaz-bala-betacthioph 8799: bim-24thioph-gly-psdap 8800: 2pmhs-25oxaz-hphe-betadcph 8801: bhs-me24thioph-bala-betapy 5 8802: ibhs-24thiaz-gly-psdaptb 8803: bhs-24thiaz-gly-betacthioph 8804: phhs-oxadiaz-bala-betathioph -264 8805: bim-24oxaz-gly-betameph 8806: phhs-nme35pyr-bala-betahdcph 8807: bim-24thiaz-bala-aspibua 8808: 2py-nme35pyr-ala-zdap 5 8809: dhim-24oxaz-ala-psdap 8810: tolhs-25oxaz-gly-beta35dbph 8811: tolhs-25methiaz-bala-zdaptb 8812: bhs-oxadiaz-gly-betafu2 8813: bhs-oxadiaz-bala-beta34dcph 0 8814: tolhs-25thiaz-gly-betadtrif 8815: tolhs-24thiaz-gly-betaomebendi 8816: tolhs-me24thioph-gly-betapy 8817: bhs-25methiaz-gly-aspbzla 8818: tolhs-24thioph-bala-betaanaphth 5 8819: ibhs-25methiaz-bala-betameph 8820: 2py-24im-leu-betapy 8821: bhs-25thiaz-gly-beta35dbph 8822: bim-42nmeim-gly-betadcph 8823: tolhs-me24thiaz-bala-betaph 0 8824: bhs-me24thiaz-leu-betaph 8825: bhs-25methiaz-gly-psdapch 8826: phhs-me25oxaz-leu-betadcph 8827: 2py-me25oxaz-ala-zdap 8828: phhs-24thiaz-bala-psdapch 5 8829: phhs-24thiaz-bala-psdaptb 8830: phhs-24thioph-gly-betacthioph 8831: ibhs-ithiadiaz-gly-betabmph 8832: bim-24oxaz-ala-betameph 8833: ibhs-25methiaz-bala-betahph 0 8834: tolhs-25oxaz-gly-betadcph 8835: ibhs-nme35pyr-bala-betahmo 8836: ibhs-ithiadiaz-bala-psdapee 8837: ibhs-25oxaz-bala-betabp 8838: bhs-oxadiaz-gly-beta3quin 5 8839: phhs-25oxaz-gly-betaamibe 8840: tolhs-25thiaz-gly-aspbzla 8841: phhs-nme35pyr-gly-beta35dbph -265 8842: 2py-25methiaz-ala-zdap 8843: tolhs-24thiaz-bala-betapyr 8844: bhs-24thiaz-bala-betabenf u 8845: ibhs-nme35pyr-gly-betafu3 5 8846: ibhs-ithiadiaz-gly-betadtrif 8847: tolhs-24thioph-gly-zdapch 8848: phhs-me25thioph-bala-betapy 8849: 2py-25thiaz-ala-zdap 8850: phhs-ithiadiaz-bala-betaipro 0 8851: bim-me25oxaz-ala-betaph 8852: ibhs-24thiaz-bala-betadcphee 8853: phhs-25methiaz-bala-betambiph 8854: tolhs-ithiadiaz-bala-betafph 8855: phhs-25thiaz-bala-betadito 5 8856: 4pmhs-26py-gly-psdap 8857: bhs-25thiaz-nmgly-betahph 8858: tolhs-24thioph-bala-betabpy 8859: phhs-24thiaz-gly-betatbuph 8860: phhs-25thiaz-gly-betabenf u 0 8861: bhs-25oxaz-gly-betaftrif 8862: phhs-25oxaz-gly-betaimid 8863: phhs-25oxaz-bala-betacph 8864: tolhs-25thiaz-bala-betabnaphth 8865: bhs-25thioph-gly-betadcph 5 8866: bhs-24oxaz-gly-zdap 8867: bhs-25thioph-gly-betameph 8868: phhs-nme35pyr-bala-betainyl 8869: phhs-me25thiaz-bala-psdap 8870: tolhs-25oxaz-bala-betathio3 0 8871: impy-25thiaz-bala-betafu3 8872: bim-25methiaz-phg-zdap 8873: phhs-24thiaz-bala-betadcph 8874: tolhs-24thiaz-gly-zdapch 8875: phhs-25methiaz-gly-zdaptb 5 8876: bhs-24thiaz-nmgly-beta23meoph 8877: tolhs-me25oxaz-leu-zdap 8878: gua-25thioph-gly-betahni -266 8879: tolhs-25thiaz-bala-betahph 8880: ibhs-25oxaz-gly-betaph 8881: bhs-ithiadiaz-bala-betadcph 8882: tolhs-25methiaz-gly-betabdimo 5 8883: phhs-nme35pyr-gly-betapbiph 8884: bhs-25thiaz-gly-suabu 8885: bim-me25oxaz-ala-betapy 8886: phhs-25oxaz-gly-betathiome 8887: impy-24thiaz-gly-betahmofu D 8888: tolhs-nme35pyr-gly-betadcphtb 8889: gua-26py-gly-betaphethioa 8890: 2py-oxadiaz-bala-betadcph 8891: tolhs-nme35pyr-gly-betadcphee 8892: tolhs-nme35pyr-bala-betaipr 5 8893: tolhs-me25thioph-leu-betaph 8894: 2py-24im-bala-betadcph 8895: ibhs-24thiaz-gly-betatos 8896: ibhs-25thiaz-gly-betaipro 8897: gua-25thioph-gly-betadbph 8898: tolhs-ithiadiaz-bala-betabmph 8899: tolhs-25methiaz-gly-betampy 8900: phhs-nme35pyr-gly-betafbph 8901: 2py-25fur-ala-zdap 8902: ibhs-24thioph-bala-betahmofu i 8903: tolhs-24thiaz-bala-betaftrif 8904: bhs-25methiaz-gly-betaheph 8905: phhs-25methiaz-gly-aspibua 8906: bim-24thiaz-bala-betahcbph 8907: 2py-25thioph-ala-psdap 8908: bim-24thioph-leu-betadcph 8909: bhs-nme35pyr-gly-beta34dcph 8910: bhs-ithiadiaz-bala-betapy 8911: ibhs-nme35pyr-bala-betadmoph 8912: 2py-me24oxaz-leu-zdap 8913: tolhs-ithiadiaz-gly-betapyee 8914: bhs-25oxaz-bala-betabnaphth 8915: phhs-nme35pyr-bala-betaomebendi -267 8916: bhs-24thioph-nmgly-betaoxaz 8917: bhs-nme35pyr-gly-betabdimo 8918: ibhs-nme35pyr-gly-betadcph 8919: bim-25methiaz-bala-betatos 5 8920: phhs-nme35pyr-bala-beta35dbph 8921: bhs-42nmeim-bala-beta3quin 8922: phhs-oxadiaz-bala-betahdbph 8923: ibhs-24thioph-bala-betabenfu 8924: phhs-ithiadiaz-bala-busu2be 3 8925: bhs-24thiaz-bala-beta34dcph 8926: sabhs-24oxaz-gly-zdap 8927: phhs-25oxaz-gly-betahdbph 8928: bhs-24thiaz-gly-betapyr 8929: ibhs-ithiadiaz-bala-betabthioph 5 8930: bhs-nme35pyr-nmgly-betadmoph 8931: ibhs-ithiadiaz-gly-betabph 8932: tolhs-25methiaz-bala-betapbiph 8933: tolhs-me24oxaz-ala-betaph 8934: phhs-25thiaz-bala-betadcphee 8935: gua-25thioph-gly-betabenfu 8936: ibhs-nme35pyr-gly-beta34dcph 8937: bhs-me24thioph-ala-beta34meoph 8938: bhs-25thiaz-nmgly-beta34meoph 8939: phhs-ithiadiaz-gly-betadmoph i 8940: phhs-nme35pyr-bala-zdaptb 8941: bhs-ithiadiaz-gly-betathioph 8942: gua-24thiaz-gly-betabmph 8943: 2py-24thioph-gly-betapy 8944: bhs-24thiaz-bala-psdap 8945: bhs-24thiaz-gly-betaibph 8946: phhs-oxadiaz-gly-betapbiph 8947: bim-triaz-bala-betadcph 8948: hs-42pym-gly-psdap 8949: tolhs-ithiadiaz-bala-suabu 8950: tolhs-24thioph-bala-betacbph 8951: phhs-me25oxaz-leu-psdap 8952: bhs-oxadiaz-gly-beta35dbph -268 8953: phhs-25oxaz-gly-betahph 8954: tolhs-me25oxaz-leu-beta34meoph 8955: bhs-oxadiaz-gly-aspibua 8956: tolhs-25methiaz-bala-betabediox 5 8957: phhs-oxadiaz-gly-psdapee 8958: phhs-nme35pyr-bala-betaipro 8959: bhs-nme35pyr-bala-betamph 8960: phhs-25oxaz-gly-betabediox 8961: bhs-25thiaz-bala-betapych 0 8962: tolhs-25methiaz-gly-betadtrif 8963: bhs-24thioph-leu-psdap 8964: 2py-24im-bala-psdap 8965: bim-42nmeim-gly-betaftrif 8966: bhs-24thioph-bala-betameph 5 8967: phhs-ithiadiaz-gly-betaphethioa 8968: 2pmhs-24thioph-bala-betabmph 8969: phhs-24thiaz-bala-betathiobe 8970: tolhs-me25thioph-ala-betadcph 8971: bhs-25methiaz-gly-zdapch 0 8972: ibhs-25methiaz-bala-betadcphee 8973: phhs-25oxaz-gly-aspibua 8974: tolhs-25thiaz-bala-busu2be 8975: phhs-24thioph-bala-betaphethio 8976: ibhs-25methiaz-gly-betahph 5 8977: tolhs-24thioph-bala-betaol 8978: tolhs-25oxaz-gly-betapyee 8979: ibhs-ithiadiaz-bala-beta35dbph 8980: bhs-25methiaz-bala-betadcphch 8981: phhs-nme35pyr-bala-betabenfu ) 8982: phhs-nme35pyr-gly-betadhbfu 8983: bhs-ithiadiaz-ala-betabpy 8984: ibhs-24thioph-gly-betahph 8985: 2py-me25thiaz-ala-betapy 8986: bim-53pyrazo-ala-psdap 5 8987: 2py-nme35pyr-bala-zdap 8988: 2py-nme35pyr-gly-aspaba 8989: bhs-oxadiaz-bala-betahdbph -269 8990: bhs-oxadiaz-gly-betaol 8991: ibhs-25oxaz-bala-betahb 8992: tolhs-25oxaz-gly-ibsdap 8993: tolhs-nme35pyr-gly-asppha 5 8994: phhs-25oxaz-gly-betafph 8995: bhs-25oxaz-ala-betadmoph 8996: bim-ithiadiaz-bala-psdap 8997: bhs-me25oxaz-leu-zdap 8998: ibhs-25thiaz-bala-busu2be 3 8999: bim-me24thioph-leu-psdap 9000: bhs-me25thioph-ala-zdap 9001: phhs-oxadiaz-bala-betahmo 9002: bhs-ithiadiaz-bala-betafluo 9003: bhs-25methiaz-bala-betafph 5 9004: bhs-53pyrazo-gly-zdap 9005: bhs-ithiadiaz-gly-betah35dc 9006: tolhs-25methiaz-gly-csdap 9007: phhs-me25thiaz-leu-zdap 9008: ibhs-nme35pyr-gly-betaet 9009: bhs-oxadiaz-ala-beta3quin 9010: phhs-24thiaz-bala-betaol 9011: bhs-25methiaz-gly-betatbuph 9012: bhs-25thiaz-gly-psdap 9013: tolhs-me24thioph-gly-psdap 5 9014: tolhs-nme35pyr-gly-betadbph 9015: bhs-24thioph-gly-betabediox 9016: tolhs-25methiaz-gly-aspaba 9017: 2pmhs-25methiaz-gly-betadtrif 9018: ibhs-25oxaz-bala-betahdcph 9019: bim-oxadiaz-gly-asppha 9020: phhs-nme35pyr-bala-beta4bph 9021: bhs-25oxaz-ala-betahmph 9022: tolhs-25oxaz-bala-betahni 9023: phhs-me24oxaz-ala-psdap 9024: bhs-42nmeim-gly-zdap 9025: phhs-25methiaz-gly-betahmo 9026: bhs-24thiaz-nmgly-betapy -270 9027: ibhs-24thiaz-bala-zdaptb 9028: bim-35thioph-bala-betadcph 9029: ibhs-ithiadiaz-gly-betaipr 9030: bhs-25thiaz-bala-aspibua 5 9031: phhs-25oxaz-gly-betadcphch 9032: 2py-me25thiaz-gly-psdap 9033: ibhs-25thiaz-bala-beta3quin 9034: bhs-25thiaz-leu-zdap 9035: dhthi-24thioph-bala-betadcph 0 9036: ibhs-oxadiaz-gly-psdapch 9037: ibhs-25oxaz-bala-zdaptb 9038: tolhs-25oxaz-gly-betaimid 9039: bhs-ithiadiaz-bala-betahc 9040: bhs-oxadiaz-gly-betampy 5 9041: bhs-me24thiaz-bala-psdap 9042: tolhs-24thiaz-gly-psdap 9043: phhs-25thiaz-bala-betapym 9044: bim-ithiadiaz-gly-betapy 9045: bhs-oxadiaz-bala-betainyl 0 9046: ibhs-25oxaz-bala-betadmph 9047: ibhs-24thiaz-bala-psdaptb 9048: bhs-24thiaz-bala-betadcph 9049: bhs-24thiaz-gly-beta34dcph 9050: bhs-ithiadiaz-gly-zdap 5 9051: agua-24thiaz-gly-psdap 9052: 2py-24thioph-leu-zdap 9053: phhs-24thioph-gly-betatbuph 9054: ibhs-25oxaz-gly-betadhbfu 9055: bhs-ithiadiaz-gly-betahni 0 9056: 2py-24thioph-bala-betabnaphth 9057: gua-26py-gly-betahni 9058: phhs-24thioph-bala-beta34meoph 9059: bhs-25methiaz-gly-betadbph 9060: bhs-triaz-leu-betapy 5 9061: bhs-ithiadiaz-gly-betaimid 9062: ibhs-24thiaz-gly-betaamibe 9063: gua-24thiaz-gly-betahph -271 9064: phhs-25methiaz-gly-zdapch 9065: phhs-oxadiaz-gly-aspaba 9066: bhs-25methiaz-leu-betadcph 9067: 2pmhs-25methiaz-bala-betahph 5 9068: phhs-24thioph-bala-beta3quin 9069: dhim-52thiaz-gly-betadcph 9070: tolhs-25oxaz-gly-aspibua 9071: 2py-nme35pyr-bala-aspbzla 9072: bhs-24thiaz-bala-betahmph 0 9073: tolhs-24thioph-bala-betahmo 9074: impy-25oxaz-gly-betadhbfu 9075: phhs-25thiaz-bala-betapytb 9076: bhs-25methiaz-gly-asppha 9077: ibhs-24thiaz-bala-betathio3 5 9078: impy-25oxaz-ser-zdap 9079: bhs-ithiadiaz-gly-betacph 9080: bhs-24thioph-gly-betadtrif 9081: tolhs-me24oxaz-gly-zdap 9082: phhs-25meth iaz-bala-betaipro 0 9083: bhs-24oxaz-bala-betapy 9084: bhs-25methiaz-gly-betacthioph 9085: bhs-25methiaz-ala-betadmph 9086: bhs-24thiaz-bala-betathio3 9087: bhs-nme35pyr-gly-betaet 5 9088: phhs-nme35pyr-bala-betaftrif 9089: bhs-24thiaz-gly-betadcphch 9090: tolhs-oxadiaz-bala-beta34dcph 9091: tolhs-24thioph-gly-betaoxope 9092: hyd-25methiaz-bala-betameph 0 9093: bhs-25oxaz-bala-betapych 9094: phhs-me24thiaz-gly-betapy 9095: bhs-24thioph-bala-betahmof u 9096: ibhs-25thiaz-gly-beta4bph 9097: tolhs-25thiaz-gly-betadhbfu 5 9098: tolhs-25oxaz-gly-betaoxaz 9099: 2py-me24oxaz-gly-betapy 9100: ibhs-25oxaz-bala-betapym -272 9101: bhs-24im-ala-psdap 9102: ibhs-oxadiaz-bala-betathioph 9103: bim-42nmeim-bala-psdap 9104: bhs-me25oxaz-bala-betaph 5 9105: 2py-me24thiaz-bala-betadcph 9106: ibhs-24thiaz-gly-betafluo 9107: bhs-oxadiaz-gly-betamethioph 9108: tolhs-24thiaz-bala-betathiome 9109: 2py-42pym-gly-psdap 0 9110: bhs-24thioph-bala-betapy 9111: bim-25oxaz-gly-zdap 9112: 2py-24pym-gly-betapy 9113: bim-35fur-gly-zdap 9114: phhs-25methiaz-bala-betafphe 5 9115: tolhs-25methiaz-bala-betapytb 9116: bim-25thioph-ala-zdap 9117: tolhs-oxadiaz-bala-betahni 9118: 2py-triaz-leu-zdap 9119: phhs-ithiadiaz-gly-beta23meoph 0 9120: tolhs-oxadiaz-bala-zdaptb 9121: bhs-triaz-ala-betapy 9122: bim-35thioph-leu-betapy 9123: bhs-25thioph-leu-zdap 9124: tolhs-25oxaz-bala-betadcph 5 9125: 2py-oxadiaz-gly-aspibua 9126: phhs-oxadiaz-bala-betatos 9127: phhs-ithiadiaz-gly-betaftrif 9128: bhs-25thiaz-bala-betaphethioa 9129: phhs-ithiadiaz-gly-psdap 0 9130: bim-26py-gly-zdap 9131: phhs-oxadiaz-bala-betafphe 9132: gua-42pym-gly-betahdbph 9133: dimethpym-26py-gly-betadcph 9134: phhs-24thiaz-gly-asppha 5 9135: tolhs-nme35pyr-gly-betaoxope 9136: bim-me24thiaz-bala-betapy 9137: phhs-oxadiaz-gly-betaamibe -273 9138: phhs-nme35pyr-gly-betamethioph 9139: phhs-25oxaz-bala-betafu3 9140: tolhs-25methiaz-bala-betaamibe 9141: ibhs-ithiadiaz-bala-betampy 5 9142: tolhs-oxadiaz-gly-betabnaphth 9143: bhs-25thiaz-gly-zdapee 9144: phhs-24thiaz-gly-betafph 9145: bhs-25methiaz-ala-betadito 9146: phhs-24thioph-bala-betadmoph D 9147: tolhs-25oxaz-gly-betahdcph 9148: tolhs-nme35pyr-gly-betaph 9149: ibhs-ithiadiaz-gly-betapych 9150: tolhs-25methiaz-gly-betadcph 9151: phhs-25oxaz-bala-betathiome 5 9152: phhs-ithiadiaz-bala-betabenfu 9153: bhs-25oxaz-gly-betadcphtb 9154: ibhs-25oxaz-gly-betathiobe 9155: bhs-25oxaz-gly-betahdbph 9156: 2py-me24thiaz-leu-zdap 0 9157: phhs-25oxaz-gly-betahmo 9158: thazep-25thiaz-gly-betapy 9159: bhs-42nmeim-hphe-zdap 9160: bim-42oxaz-bala-zdap 9161: phhs-25oxaz-gly-aspbzla 5 9162: ibhs-25thiaz-gly-betafu3 9163: ibhs-24thiaz-bala-asppha 9164: ibhs-ithiadiaz-bala-betadcphtb 9165: tolhs-me24oxaz-gly-betapy 9166: tolhs-24thiaz-gly-betadcphee 0 9167: tolhs-25thiaz-gly-betathioph 9168: bim-24thioph-bala-betahcbph 9169: ibhs-25methiaz-bala-betambiph 9170: phhs-nme35pyr-gly-betampy 9171: ibhs-25thiaz-bala-betahdcph 5 9172: tolhs-25oxaz-bala-asppha 9173: bhs-24thiaz-leu-betadcph 9174: bhs-me24oxaz-ala-psdap -274 9175: phhs-nme35pyr-gly-betabthioph 9176: gua-26py-gly-betafu3 9177: 2pmhs-24thioph-bala-betathioph 9178: ibhs-25methiaz-bala-asppha 5 9179: phhs-25oxaz-gly-betapych 9180: bhs-24thiaz-phe-betapy 9181: tolhs-25thiaz-bala-betaheph 9182: ibhs-24thiaz-gly-betapyr 9183: bhs-24thiaz-bala-betafluo 0 9184: bim-25thioph-gly-betainyl 9185: bhs-me24thiaz-bala-beta34meoph 9186: bhs-25oxaz-nmgly-betaanaphth 9187: bhs-24thiaz-bala-betahcbph 9188: bhs-nme35pyr-bala-betah35dc 5 9189: ur-24thiaz-gly-betadcph 9190: phhs-25thiaz-gly-zdapch 9191: tolhs-25thiaz-gly-betahmof u 9192: bhs-25oxaz-nmgly-beta34dcph 9193: tolhs-oxadiaz-gly-beta4bph 0 9194: tolhs-25methiaz-gly-betaol 9195: phhs-24thioph-bala-betapyr 9196: bim-nme35pyr-gly-asppha 9197: 2py-24thioph-bala-betaoxope 9198: bhs-oxadiaz-bala-betacph 5 9199: ibhs-oxadiaz-bala-betacbph 9200: 2py-me24thiaz-gly-zdap 9201: ibhs-24thiaz-bala-betahbcph 9202: bhs-24thioph-bala-suabu 9203: tolhs-24thioph-gly-psdaptb 0 9204: phhs-oxadiaz-gly-betahmph 9205: phhs-25methiaz-bala-betaheph 9206: ibhs-25methiaz-gly-betadcphee 9207: bhs-25thiaz-gly-betadcphee 9208: bhs-25thiaz-gly-betal 3bendi 5 9209: bhs-24thioph-gly-betal 3bendi 9210: bhs-25thiaz-gly-betamethioph 9211: 2py-me24oxaz-bala-zdap -275 9212: 2py-25oxaz-gly-betahmofu 9213: phhs-25thiaz-bala-betabenfu 9214: bhs-25oxaz-ala-betadmph 9215: ibhs-24thiaz-gly-betabenf u 5 9216: phhs-oxadiaz-gly-betatbuph 9217: 2py-me25oxaz-bala-betapy 9218: tolhs-nme35pyr-gly-betadito 9219: bhs-25thiaz-nmgly-betathio3 9220: bhs-nme35pyr-nmgly-betahph D 9221: bhs-25oxaz-ala-betathio3 9222: phhs-24thiaz-gly-betambiph 9223: bhs-24thiaz-bala-betaamibe 9224: bhs-24thioph-bala-betabnaphth 9225: tolhs-oxadiaz-gly-zdapch 5 9226: ibhs-24thiaz-gly-betaftrif 9227: phhs-ithiadiaz-gly-betadmph 9228: ibhs-25thiaz-bala-betacthioph 9229: bhs-53pyrazo-gly-betapy 9230: phhs-25thiaz-gly-betaoxaz D 9231: ibhs-nme35pyr-bala-psdap 9232: bhs-nme35pyr-bala-betal 3bendi 9233: ibhs-25oxaz-bala-betabthioph 9234: bhs-25oxaz-bala-betadcphee 9235: tolhs-25methiaz-bala-betamesu 5 9236: tolhs-25methiaz-gly-betabmph 9237: bhs-24oxaz-gly-betainyl 9238: pahs-25methiaz-bala-betameph 9239: bhs-25nmethiaz-ala-betacph 9240: ibhs-25thiaz-gly-betathiobe D 9241: bhs-42nmeim-gly-betadcph 9242: tolhs-oxadiaz-gly-betahni 9243: ibhs-24thiaz-bala-betatos 9244: dimethpym-24thiaz-gly-betameph 9245: tolhs-25thiaz-gly-betapyee 5 9246: hs-24thiaz-gly-betapy 9247: phhs-24thiaz-gly-betacthioph 9248: bim-35thioph-bala-psdap -276 9249: tolhs-25methiaz-gly-betaamibe 9250: bim-25oxaz-gly-betadcph 9251: 2py-46pym-gly-betapy 9252: bhs-oxadiaz-ala-betaipro 5 9253: dhim-52thiaz-gly-betameph 9254: 2py-ithiadiaz-gly-betadcph 9255: bhs-25methiaz-nmgly-betahmph 9256: bim-24thioph-gly-betadmph 9257: bhs-25thiaz-bala-aspbzla 0 9258: ibhs-25thiaz-bala-betafphe 9259: ibhs-25methiaz-gly-betaanaphth 9260: tolhs-24thioph-bala-betahcbph 9261: phhs-25oxaz-bala-psdaptb 9262: ibhs-24thioph-gly-betahdbph 5 9263: ibhs-25oxaz-bala-betainyl 9264: tolhs-25oxaz-gly-betahni 9265: bhs-oxadiaz-bala-betamethioph 9266: 2py-me24oxaz-ala-psdap 9267: tolhs-me24oxaz-ala-beta34meoph 0 9268: bhs-25thiaz-bala-betapyr 9269: tolhs-me24oxaz-leu-psdap 9270: tolhs-24thioph-gly-betapytb 9271: bhs-oxadiaz-bala-betapych 9272: ibhs-25methiaz-bala-betaphethio !5 9273: 2py-thiadiaz-ala-psdap 9274: bhs-oxadiaz-nmgly-betal 3bendi 9275: tolhs-nme35pyr-gly-betainyl 9276: ibhs-25thiaz-bala-betabthioph 9277: bim-triaz-gly-zdap 30 9278: tolhs-24thioph-gly-betacthioph 9279: ibhs-nme35pyr-gly-betadhbfu 9280: bhs-25thiaz-bala-betahmofu 9281: ibhs-25oxaz-gly-betaomebendi 9282: tolhs-me25thioph-gly-zdap 35 9283: phhs-ithiadiaz-bala-betaheph 9284: ibhs-25thiaz-bala-zdapee 9285: tolhs-nme35pyr-bala-betabph -277 9286: phhs-me24oxaz-bala-betapy 9287: 2py-me25thioph-gly-psdap 9288: bim-24thiaz-gly-betaomebendi 9289: 2py-42pym-gly-betadcph 9290: bim-24im-bala-betadcph 9291: ibhs-25methiaz-gly-betafu2 9292: bhs-24thioph-ala-ibsdap 9293: phhs-ithiadiaz-gly-betapbiph 9294: 2pmhs-25thiaz-gly-betathiome 9295: phhs-25thiaz-bala-betaoxope 9296: phhs-me25oxaz-gly-beta34meoph 9297: tolhs-25methiaz-bala-betahni 9298: ibhs-nme35pyr-gly-betaomebendi 9299: bim-42pym-gly-psdap 9300: tolhs-oxadiaz-gly-betaet 9301: tolhs-nme35pyr-gly-betafph 9302: bim-25thiaz-leu-zdap 9303: bhs-ithiadiaz-bala-betampy 9304: phhs-25methiaz-bala-betatrif 9305: phhs-25thiaz-gly-betaph 9306: sabhs-25thioph-gly-betapy 9307: phhs-25oxaz-gly-betahmofu 9308: imhs-42nmeim-gly-betameph 9309: bhs-ithiadiaz-bala-betahdcph 9310: 2py-35thioph-ala-psdap 9311: bim-42nmeim-gly-betamethi 9312: bhs-25oxaz-ala-beta23meoph 9313: tolhs-25thiaz-gly-betadcphch 9314: phhs-oxadiaz-gly-betabpy ) 9315: bhs-24oxaz-gly-betadcph 9316: bhs-25methiaz-ala-betaipro 9317: tolhs-24thiaz-gly-psdapch 9318: bim-me24thiaz-bala-betadcph 9319: tolhs-nme35pyr-bala-psdap 9320: phhs-25thiaz-bala-betafbph 9321: bim-25fur-ala-betapy 9322: ibhs-ithiadiaz-gly-betathiome -278 9323: bhs-oxadiaz-bala-betabediox 9324: dhim-25thiaz-ala-betainyl 9325: bim-25thiaz-gly-asppha 9326: bhs-nme35pyr-bala-betahmof u 5 9327: bhs-ithiadiaz-bala-betathioph 9328: bhs-nme35pyr-bala-betacbph 9329: bhs-25methiaz-bala-aspbzla 9330: 2py-me25thioph-gly-betadcph 9331: tolhs-ithiadiaz-bala-betatrif D 9332: 2pmhs-25thiaz-bala-beta4bph 9333: ibhs-nme35pyr-gly-betameph 9334: tolhs-25thiaz-bala-betatrif 9335: bim-me25thioph-ala-betaph 9336: tolhs-24thiaz-gly-beta3quin 5 9337: bhs-26py-ala-betameph 9338: bhs-42oxaz-bala-psdap 9339: 2py-triaz-bala-betadcph 9340: bhs-25methiaz-ala-betabpy 9341: tolhs-24thioph-bala-zdap D 9342: bhs-me25oxaz-leu-psdap 9343: phhs-25methiaz-bala-betabdimo 9344: bhs-nme35pyr-bala-suabu 9345: phhs-25thiaz-bala-betahc 9346: phhs-24thiaz-gly-betaanaphth 5 9347: 2py-52thiaz-gly-betameph 9348: bhs-nme35pyr-gly-asppha 9349: dimethpym-42nmeim-gly-betadcph 9350: bhs-ithiadiaz-bala-betapbiph 9351: bhs-oxadiaz-gly-betaph 3 9352: ibhs-ithiadiaz-gly-betafu2 9353: phhs-25oxaz-bala-betahbcph 9354: bhs-24thiaz-met-betapy 9355: bhs-ithiadiaz-bala-betatbuph 9356: bhs-ithiadiaz-ala-betathioph 5 9357: 2py-25oxaz-gly-beta34meoph 9358: 2py-25thiaz-ala-betadcph 9359: 2py-me25thioph-gly-betapy -279 9360: phhs-ithiadiaz-bala-beta3quin 9361: phhs-nme35pyr-gly-betaomebendi 9362: bhs-oxadiaz-bala-psdapch 9363: ibhs-25oxaz-gly-betaipr 9364: ibhs-24thiaz-gly-betacthioph 9365: phhs-me25thiaz-ala-betaph 9366: bhs-24oxaz-leu-zdap 9367: phhs-nme35pyr-gly-betah35dc 9368: phhs-me25thioph-ala-beta34meoph 9369: dhpyrr-25thiaz-gly-zdap 9370: phhs-25thiaz-bala-betaomebendi 9371: bhs-52thiaz-gly-betadcph 9372: phhs-ithiadiaz-gly-betadbph 9373: 2py-25fur-ala-betadcph 9374: gua-24thiazme-gly-betapy 9375: tolhs-24thiaz-gly-beta35dbph 9376: tolhs-25oxaz-gly-betadbph 9377: phhs-nme35pyr-gly-zdap 9378: bhs-me24oxaz-gly-betaph 9379: gua-25thiaz-gly-betaimid 9380: tolhs-25oxaz-bala-betaomebendi 9381: tolhs-24thiaz-gly-betaipro 9382: bim-triaz-ala-betapy 9383: bhs-24thioph-gly-zdapee 9384: ibhs-nme35pyr-gly-betafluo 9385: ibhs-25oxaz-bala-betaomebendi 9386: phhs-25methiaz-bala-betapytb 9387: bhs-25methiaz-bala-betapyr 9388: tolhs-25oxaz-bala-betacph 9389: phhs-oxadiaz-bala-aspbzla 9390: tolhs-25methiaz-bala-betaftrif 9391: tolhs-ithiadiaz-bala-betabthioph 9392: bhs-24thiaz-gly-betamesu 9393: bhs-24thiaz-ala-betadhbfu 9394: tolhs-24thioph-bala-betadcphch 9395: ibhs-nme35pyr-bala-zdapch 9396: bhs-oxadiaz-gly-betahph -280 9397: bhs-25oxaz-gly-betaol 9398: tolhs-24thioph-gly-zdap 9399: bhs-oxadiaz-ala-betadmoph 9400: phhs-oxadiaz-bala-betapyr 9401: bhs-nme35pyr-bala-aspbzla 9402: 2py-25oxaz-bala-betamethi 9403: bhs-oxadiaz-gly-betahcbph 9404: tolhs-ithiadiaz-bala-aspaba 9405: ibhs-oxadiaz-bala-betambiph 9406: bim-thiadiaz-ala-zdap 9407: phhs-24thioph-bala-betatbuph 9408: bhs-25thiaz-gly-betaipr 9409: tolhs-25methiaz-bala-betacthioph 9410: phhs-24thiaz-bala-betadmoph 9411: gua-42pym-gly-betal 3bendi 9412: tolhs-25methiaz-gly-betahmph 9413: ibhs-25oxaz-gly-betameph 9414: bhs-24thiaz-bala-psdaptb 9415: bhs-nme35pyr-gly-betadcphtb 9416: bhs-24thiaz-bala-betadmph 9417: phhs-ithiadiaz-gly-busu2be 9418: bim-24thiaz-ala-betainyl 9419: phhs-25oxaz-bala-betahmph 9420: phhs-25thiaz-gly-psdapee 9421: ibhs-nme35pyr-bala-betahmph 9422: gua-24oxaz-gly-betaphethioa 9423: 2pmhs-42nmeim-gly-betadmoph 9424: ibhs-24thioph-bala-betadbph 9425: phhs-ithiadiaz-bala-betabmph 9426: bim-24oxaz-ala-betapy 9427: tolhs-25methiaz-gly-betafbph 9428: bhs-25oxaz-gly-betapy 9429: bhs-nme35pyr-bala-betafph 9430: 2py-24thiaz-bala-betahni 9431: phhs-ithiadiaz-bala-betafu2 9432: impy-42nmeim-phe-betadcph 9433: tolhs-24thioph-gly-betadcph -281 9434: bhs-ithiadiaz-gly-betafbph 9435: bhs-nme35pyr-gly-betameph 9436: bhs-25oxaz-gly-betabpy 9437: ibhs-25oxaz-gly-psdapee 9438: bim-25fur-bala-betadcph 9439: bhs-25thiaz-gly-aspbzla 9440: 2py-oxadiaz-ala-psdap 9441: bim-24thiaz-leu-zdap 9442: tolhs-oxadiaz-gly-betampy 9443: 2pmhs-25thioph-ala-betameph 9444: bhs-25thioph-ala-zdap 9445: bhs-24thioph-gly-betaomebendi 9446: phhs-25oxaz-gly-betaibph 9447: bhs-42nmeim-leu-zdap 9448: bhs-oxadiaz-leu-betadcph 9449: bhs-ithiadiaz-ala-betahmph 9450: bhs-25methiaz-gly-betadcphch 9451: tolhs-nme35pyr-gly-betaphethioa 9452: gua-26py-gly-betatos 9453: bhs-24thiaz-bala-betadtrif 9454: ibhs-ithiadiaz-bala-betaibph 9455: dhim-26py-ala-betaph 9456: bim-35thioph-ala-psdap 9457: phhs-25thiaz-bala-betaamibe 5 9458: 2py-26py-ala-psdap 9459: 2py-25thiaz-gly-beta3quin 9460: bhs-25methiaz-bala-betapym 9461: tolhs-24thiaz-bala-betapbiph 9462: tolhs-ithiadiaz-gly-betamesu D 9463: phhs-24thioph-bala-betathiome 9464: ibhs-25oxaz-gly-betaphethio 9465: tolhs-oxadiaz-gly-betadmph 9466: ibhs-24thiaz-bala-betadbph 9467: bim-nme35pyr-bala-aspaba 5 9468: 2py-35fur-ala-zdap 9469: phhs-ithiadiaz-bala-betahcbph 9470: ibhs-25methiaz-gly-betapbiph -282 9471: tolhs-25methiaz-bala-betadcphch 9472: ibhs-25methiaz-gly-betatbuph 9473: bim-42oxaz-bala-betapy 9474: phhs-24thiaz-gly-zdapch 9475: tolhs-24thiaz-bala-betatos 9476: bhs-42oxaz-bala-betapy 9477: bim-35fur-bala-betadcph 9478: 2py-me24thioph-ala-betapy 9479: tolhs-25oxaz-gly-betamesu 9480: tolhs-nme35pyr-gly-betabnaphth 9481: ibhs-oxadiaz-gly-betahdcph 9482: tolhs-24thiaz-bala-aspbzla 9483: phhs-oxadiaz-bala-zdapch 9484: ibhs-ithiadiaz-gly-psdapee 9485: ibhs-nme35pyr-gly-beta35dbph 9486: ibhs-24thiaz-gly-betabnaphth 9487: bhs-ithiadiaz-gly-betafph 9488: bhs-42nmeim-gly-betafluo 9489: phhs-25thiaz-bala-betatrif 9490: tolhs-nme35pyr-bala-betaph 9491: ibhs-25methiaz-bala-beta34dcph 9492: bim-24oxaz-gly-zdap. 9493: bhs-25thiaz-bala-beta4bph 9494: bhs-25thioph-gly-betapy 9495: bhs-25methiaz-bala-psdapch 9496: bhs-25oxaz-nmgly-betadmph 9497: phhs-me25thioph-ala-betapy 9498: ibhs-oxadiaz-bala-betafu3 9499: ibhs-24thiaz-bala-betamethi 9500: phhs-24thioph-bala-betatrif 9501: tolhs-25oxaz-gly-betathio3 9502: bim-25thioph-gly-psdap 9503: phhs-ithiadiaz-bala-betahdbph 9504: toihs-25oxaz-gly-betaomebendi 9505: phhs-me24thioph-ala-psdap 9506: ibhs-ithiadiaz-gly-betafph 9507: phhs-oxadiaz-bala-betaol -283 9508: bhs-ithiadiaz-ala-betadhbfu 9509: ibhs-oxadiaz-gly-betabnaphth 9510: bhs-nme35pyr-ala-betadhbf u 9511: bhs-ithiadiaz-nmgly-betaipro 9512: 2py-oxadiaz-bala-zdap 9513: phhs-25oxaz-bala-beta23meoph 9514: bhs-me24oxaz-bala-betapy 9515: ibhs-24thiaz-gly-zdap 9516: bhs-me25thioph-leu-psdap 9517: phhs-oxadiaz-bala-betafbph 9518: bhs-ithiadiaz-bala-betabmph 9519: bhs-25methiaz-gly-betaphethioa 9520: bhs-24thiaz-bala-suabu 9521: tolhs-25methiaz-bala-betacbph 9522: tolhs-25methiaz-gly-betaheph 9523: phhs-25thiaz-gly-beta34dcph 9524: impy-25methiaz-nmgly-psdap 9525: bhs-oxadiaz-nmgly-betabpy 9526: bhs-25thiaz-bala-zdap 9527: tolhs-24thiaz-gly-busu2be 9528: 2py-24thiaz-leu-psdap 9529: bhs-nme35pyr-gly-betadmoph 9530: ibhs-25thiaz-bala-betafluo 9531: tolhs-nme35pyr-gly-betahmph 9532: tolhs-oxadiaz-gly-betahb 9533: bhs-ithiadiaz-gly-betaheph 9534: phhs-oxadiaz-bala-betaomebendi 9535: bhs-oxadiaz-gly-zdap 9536: bhs-25methiaz-gly-betahdcph 9537: ibhs-25thiaz-bala-zdap 9538: tolhs-25methiaz-bala-betathiome 9539: phhs-ithiadiaz-bala-betaimid 9540: phhs-24thiaz-gly-betapyee 9541: tolhs-ithiadiaz-bala-betaphethioa 9542: ibhs-24thiaz-bala-zdap 9543: phhs-25thiaz-gly-betaomebendi 9544: bhs-25oxaz-bala-psdaptb -284 9545: bhs-25oxaz-gly-betaph 9546: ibhs-25methiaz-gly-betahc 9547: tolhs-25methiaz-bala-betab 9548: tolhs-nme35pyr-bala-betadcphch 5 9549: gua-25thioph-gly-betamesu 9550: tolhs-24thioph-bala-betadcphee 9551: bhs-oxadiaz-ala-betaoxaz 9552: ibhs-25oxaz-gly-betathio3 9553: phhs-24thioph-gly-betafluo 3 9554: bim-25oxaz-gly-betameph 9555: bim-25methiaz-gly-aspibua 9556: bim-me25oxaz-bala-psdap 9557: ibhs-oxadiaz-gly-zdapch 9558: 2py-oxadiaz-bala-aspaba 5 9559: bhs-oxadiaz-nmgly-betainyl 9560: tolhs-25methiaz-bala-betaipro 9561: bhs-25fur-gly-betapy 9562: bhs-25thioph-ala-psdap 9563: ibhs-oxadiaz-gly-betadcphch 0 9564: phhs-25oxaz-bala-betafluo 9565: phhs-25oxaz-bala-betadbph 9566: ibhs-oxadiaz-gly-betaomebendi 9567: ibhs-nme35pyr-gly-betaphethio 9568: bhs-25oxaz-bala-betabpy 5 9569: phhs-25thiaz-bala-betaipro 9570: 2py-nme35pyr-ala-betapy 9571: ibhs-24thiaz-bala-betahb 9572: bhs-24thioph-gly-betaimid 9573: bhs-25methiaz-bala-betaoxope 0 9574: ibhs-ithiadiaz-bala-betahmph 9575: 2py-24thiaz-leu-zdap 9576: bhs-25methiaz-gly-betapym 9577: bhs-ithiadiaz-ala-betaoxaz 9578: ibhs-24thioph-bala-betaimid 5 9579: ibhs-24thioph-gly-beta23meoph 9580: bim-me24oxaz-gly-zdap 9581: tolhs-nme35pyr-gly-betahc -285 9582: bhs-25thiophme-gly-betapy 9583: bhs-25oxaz-gly-betambiph 9584: phhs-25oxaz-bala-betadito 9585: phhs-25methiaz-gly-betatbuph 9586: tolhs-24thiaz-bala-betapytb 9587: impy-25thiaz-bala-betah35dc 9588: bhs-nme35pyr-bala-zdaptb 9589: 2py-26py-ser-zdap 9590: dhim-42pym-gly-betadcph 9591: 2py-me25thioph-bala-betadcph 9592: tolhs-oxadiaz-bala-betathiobe 9593: ibhs-24thiaz-bala-betaipr 9594: phhs-nme35pyr-bala-betahcbph 9595: gua-24thiaz-gly-betaipro 9596: tolhs-oxadiaz-bala-betatos 9597: phhs-24thiaz-bala-betatrif 9598: tolhs-ithiadiaz-gly-betadhbfu 9599: 2pmhs-25methiaz-bala-zdap 9600: gua-24oxaz-gly-betabmph 9601: bhs-oxadiaz-bala-zdaptb 9602: bhs-oxadiaz-nmgly-betadhbfu 9603: phhs-25thiaz-gly-betahmo 9604: phhs-ithiadiaz-gly-betamethioph 9605: bhs-ithiadiaz-leu-zdap 9606: tolhs-24thiaz-gly-betapytb 9607: ibhs-24thioph-gly-betaet 9608: phhs-25thiaz-gly-betainyl 9609: tolhs-oxadiaz-bala-betathio3 9610: bhs-25oxaz-ala-betabnaphth 9611: bim-nme35pyr-gly-zdap 9612: 2py-25thioph-gly-betadcph 9613: phhs-24thioph-gly-betadcphee 9614: ibhs-24thioph-gly-betal 3bendi 9615: bhs-42pym-gly-zdap 9616: 2py-24im-bala-betapy 9617: phhs-25methiaz-gly-psdapee 9618: bhs-24im-leu-betadcph -286 9619: phhs-24thiaz-bala-betafphe 9620: tolhs-24thiaz-bala-psdap 9621: bhs-nme35pyr-bala-betapy 9622: impy-42nmeim-gly-betal 3bendi 9623: phhs-25thiaz-bala-betadhbf u 9624: ibhs-24thiaz-bala-betabpy 9625: phhs-oxadiaz-bala-aspibua 9626: ibhs-nme35pyr-gly-betafu2 9627: 2pmhs-42nmeim-bala-ibsdap 9628: bhs-25thiaz-gly-betahc 9629: bim-42pym-gly-betainyl 9630: bim-me25thiaz-gly-psdap 9631: phhs-ithiadiaz-bala-betafu3 9632: bhs-24thioph-nmgly-betathioph 9633: bim-42pym-gly-zdap 9634: ibhs-24thiaz-gly-betabmph 9635: phhs-24thioph-gly-beta23meoph 9636: phhs-24thiaz-gly-betadito 9637: phhs-25oxaz-gly-beta3quin 9638: bim-nme35pyr-gly-aspibua 9639: bim-oxadiaz-gly-aspibua 9640: tolhs-25thiaz-gly-betahcbh 9641: ibhs-ithiadiaz-gly-asppha 9642: impy-25oxaz-met-psdap 9643: ibhs-nme35pyr-bala-betahc 9644: 2py-25fur-gly-betadcph 9645: tolhs-24thioph-bala-betaomebendi 9646: gua-24thiaz-gly-betahmofu 9647: ibhs-25methiaz-bala-zdapch 9648: 2py-24thiaz-bala-zdap 9649: bhs-24thiaz-gly-beta4bph 9650: phhs-24thioph-gly-betahdcph 9651: bhs-42nmeim-bala-psdap 9652: phhs-25thiaz-gly-aspbzla 5 9653: 2py-24thioph-ala-betadcph 9654: bhs-24thiaz-ala-betahmph 9655: bhs-triaz-leu-zdap -287 9656: tolhs-nme35pyr-bala-betaftrif 9657: bhs-ithiadiaz-bala-betal 3bendi 9658: ibhs-25methiaz-gly-betahmo 9659: ibhs-24thioph-gly-betahmofu 5 9660: bhs-25oxaz-bala-asppha 9661: tolhs-25methiaz-gly-betaftrif 9662: bhs-oxadiaz-gly-betacph 9663: phhs-25oxaz-gly-betabenfu 9664: dhim-24oxaz-ala-betadcph 0 9665: tolhs-25oxaz-bala-aspaba 9666: bhs-25thiaz-bala-psdaptb 9667: bhs-25oxaz-nmala-psdap 9668: 4pmhs-24thioph-bala-betameph 9669: bhs-nme35pyr-bala-betahmo 5 9670: ibhs-nme35pyr-gly-betaanaphth 9671: dhim-52thiaz-ala-betapy 9672: bim-52thiaz-gly-psdap - 288 The abbreviations after the colon in the above list in each case represent, separated by a hyphen, a structural element A, E, G and L, where the abbreviations have the following meanings: A Abbreviation A = Abbreviation N2p thpymn 2py N N dhim . nmhs H o9 H !Nl bim N 4pmhs N imhs H 2 N hs 0 0 bhs N sabhs - ' 0 NI H NH NH NH gua N bgua
H
2 NNH I H:r 0 N N 2pmhs N dhpyrr H N NO impy ur HH hyd ibhs C H O OHO 0 0 N 3pmhS H 2 N N agua '_-_H_ HN _____ - 289 A =Abbreviation A = Abbreviation CNdhthi Ndimethpym S H ~ci1thazep kihts NCN rN Ad cma O\+thpy H N tolhs E =Abbreviation E =Abbreviation S,24thioph iN-( Aoxadiaz N-N \/nme35pyr /A42oxaz H H0 'rme24im /t35pyrazo H -1-N__ __ 0 0 24hopm S~125thiophme \ Iiohm H H thiaciiaz N 0/A25fur N-N _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ - 290 E = Abbreviation E = Abbreviation 0 0 H S 25thiaz H S 52thiaz HO0 s 0 HN N /taz 35thioph N-N H 0 0 )- N 35fur N 42nmeim H INth1-N 0 23thioph m2thiazm24ha 0 H H N / 24thiazme N0 24py2py 0 H 0 0 .. N35py N~ I 25py N H H 0v J-N 46pym -N 24chifl NH N ~-N. -~t me25thiaz me24thiaz N 0 H H 0H 0 N24py *N I N 26py H 0 H 0 1N r, -. 24pym~ *N 42pym
N::'N
- 291 E =Abbreviation E = Abbreviation H N0 N-,s 0 I :NN(NN .
26pyrazi 25methiaz N 0H' H S 25thioph 1 N\N53pyrazo N24oxaz 1 N 24im 0 1"0__ _ _ _ 25oxaz fthiadiaz 0 H SN 0 H H 0 me25thoph 3J me24thoph 0 00 S\ 2thioph - 292 G = Abbreviation G = Abbreviation H 0 gly leu N N H H 0 phg met H H 0 N VN ala hphe H 0 ~N j0 phe 1 . nmala 0 I~N ser 0 nmgly OH bala 0 - 293 L = Abbreviation L = Abbreviation OH .N OH 0 betapy 0 betadcph N N ,O OaHO Spibua O NHOaspaba HOH OHOH O -IN OH betapbiph HO O betahdcph Cl CI H H OIN H IN OH 0 beta34meoph 0 betaheph OF 0 0 YOH O0 0 0O H IO zdapee H O Zdaptb O 0 .N OH 0 betameph .N OH betampy N.N H OH H 0 I 0Lea3ephbtiy - 294 L = Abbreviation L = Abbreviation OHH OHN OH betatbu INbetathioph H OH N OH 7N OH 0N 0 a betaanaphth betaoxaz -O OH _N OH O betambiph H 0 zdap NIN % OH 0 OH ,IN OH 0 betabnaphth HN1.- 0' psdap O 0 H 0 betapytb betadCphee - 295 L = Abbreviation L = Abbreviation H OH s0 H HN 0 ibsdap busu2be N OH b _____ ffH 0 O OH N OH N OH 0 beta3quin 0 betal 3bendi -- O H 1. N OH H NN OH r 0 betadbph B0 OH betafbph BrFBr F Br N OH j 5 OH betacbph 0 betafluo Br CI ,N OH N OH 0 betabpy HO betahcbph Br N Br ACl H H N OH .N OH betapym 0 betamethi NN Ns N s o psdapch s% psdaptb 0 - 296 L = Abbreviation L = Abbreviation OH N OH - ~ betacthioph b 0 thioph Cl OH OH o betaome- O 0 betabenfu O 0 bendi OO 0N OH OH 0 O betabthiop HN C betaoxope Br C OH HOH N NH F H H NI ObetafHu2 betafu3 0 betadcphtb betadcphch Cl Cl Cl C H N OH 0 betathlo30 beta4bph Br H H OH betadmph IN OH betadmoph 0 0 _ __ - 297 L = Abbreviation L = Abbreviation OHH N OH rT,, OHfM OH betathiobe HN suabu 1121 ON0 0 N OH NOH betathiome betatos ) S _ _S H H N OH N OH 0o betaphethio 0 OH 0 betaphe s s thioa H OH NOHbetaol HO 0 betahph HO H OH N OH IN OH )""YOH HO O betahmph NH 0 betaamibe OH N OH N OH betabediox beta34dcph 0,.) ci H H N OH N OH betadtrif betacph FC C CI _ - 298 L = Abbreviation L = Abbreviation 0 H zdapch HN O AN"y O .. N O 0 IN OH N OH betabph betaftrif Br F CF 3 N OH OH beta35dbph 0 betabmph Br Br Br HO OH betaibph H betahmo SBr0 OHbtamf HNO ean N OH OH HO~ 0 betahmofu HO0betahni 040 NO 2 HO betahb HO betahc Br Cl H O N OH OH betampy betamesu It 0 H H N OH IN OH 0 betadito N0 betapyr EtO OEt N - 299 L = Abbreviation L = Abbreviation H N OH betatrif betabdimo CFO Br 0 Br O H H _IN< 0H betaipr OH betaet iPr 0 Et 0 H H kN 0 k OO OH betafphe betadhbfu F _ Hp HO 0betahbcph 0betaipro H OH N OH 0 betahdbph 0 betah35dc Br Br C C1 OH OH H H 0 HO asppha 0 Haspbzla 6 o betapyee betapych In the table, Et means ethyl and iPr means iso-propyl. 5 Compounds of the general formula I and the starting materials used to prepare them can - 300 generally be prepared by the methods of organic chemistry known to the skilled worker, as described in standard works such as, for example, Houben-Weyl, "Methoden der Organischen Chemie", Thieme-Verlag, Stuttgart, or March "Advanced Organic Chemistry", 4th Edition, Wiley & Sons. Compounds of the formula I can be synthesized either by a "classical" method in solution by condensing individual building blocks in solution or on a polymeric support, in each case using reaction conditions known and suitable for the particular reactions. It is moreover possible to make use of variants which are known per se but are not mentioned here. The coupling of the individual fragments and the elimination of the protective groups can take place by known processes analogous to the methods of peptide synthesis as described in standard works, for example, in Bodanszky "The Practice of Peptide Synthesis", 2nd Edition, Springer-Verlag 1994, and Bodanszky "Principles of Peptide Synthesis", Springer-Verlag 1984. Methods for solid-phase synthesis and applications are described, for example, in J. Am. Chem. Soc. 1972, 94, 3102 et seq., Int. J. Peptide Protein Res. 1990, 35, 161-214; Angew. Chem. 1992, 375-391, J. Med. Chem. 1994, 37, 1233, J. Med. Chem. 1994, 37, 1385, and Angew. Chem. 1996, 108, 2437-2488. A general review of the conventional methods of peptide synthesis and a list of suitable reagents is furthermore to be found in NOVABIOCHEM 1999 "Catalog and Peptide Synthesis Handbook". The general synthesis of compounds of the formula I is described in schemes 1-8. Unless indicated otherwise, all the starting materials and reagents can be bought or can be prepared by conventional methods from precursors which can be bought. Scheme 1-3 describes in general the synthesis of compounds of the formula I. The synthesis can in principle take place by N-terminal extension from building block II (Scheme 1). Coupling of 11 with Ill gives IV, and elimination of the protective group SG3 to V and renewed coupling with VI leads to VII. Alternatively, compounds of type I can also be prepared by C-terminal extension starting from building block VI. Coupling with Vill gives IX, and elimination of the protective group SG2 and renewed coupling with Il leads to VII (Scheme 2). Compounds of the general formula I are finally obtained after elimination of the - 301 protective group SG1 in VII (Scheme 3). To make a more detailed description possible, the synthesis schemes show carboxylic acid derivative radicals, such as, for example, the group -CO-R 1 , a preferred embodiment of the group Z, in place of the group T. Synthesis with the corresponding group Z proceeds analogously. In the case where the 5 radicals R 2 , R , R 4 , R , R , 0 or A contain functional groups which interfere with linkage of the building blocks mentioned, these functional groups are likewise blocked by suitable protective groups. The couplings mentioned can be carried out with the aid of conventional coupling 0 reagents using suitably protected amino and carboxylic acid derivatives (Y=OH in formula IlIl and VI). Another method comprises the use of preactivated carboxylic acid derivatives, preferably of carbonyl halides, symmetrical or mixed anhydrides, or of so called active esters (Y = halide, active ester, anhydride; in formula IlIl and VI), which are normally used for acylating amines. These activated carboxylic acid derivatives can also 5 be prepared in situ. The couplings can usually be carried out in inert solvents in the presence of an acid binding agent, preferably of an organic base such as, for example, triethylamine, pyridine, diisopropylethylamine, N-methylmorpholine, quinoline; it may also be advantageous to add an alkali metal or alkaline earth metal hydroxide, carbonate or bicarbonate or another salt of a weak acid of the alkali metals or alkaline earth metals, preferably of potassium, sodium, calcium or cesium. The reaction time depends on the conditions used and is between some minutes and 14 days, and the reaction temperature is between -40C and 1400C, preferably between -20*C and 100C. Examples of suitable inert solvents are hydrocarbons such as hexane, heptane, petroleum ether, toluene, benzene or xylene; chlorinated hydrocarbons such as trichloroethylene, 1,2-dichloroethane, tetrachloromethane, chloroform, dichloromethane; alcohols such as methanol, ethanol, isopropanol, n-propanol, n-butanol or tert-butanol; ethers such as diethyl ether, methyl tert-butyl ether, diisopropyl ether, tetrahydrofuran, dioxane; glycol ethers such as ethylene glycol monomethyl ether or monoethyl ether, ethylene glycol dimethyl ether; ketones such as acetone, butanone; amides such as dimethylformamide (DMF), dimethylacetamide or acetamide; nitriles such as acetonitrile; sulfoxides such as dimethyl sulfoxide; carboxylic acids such as formic acid or acetic acid; nitro compounds such as nitromethane or nitrobenzene; esters such as ethyl acetate; water; or mixtures of the solvents mentioned.
- 302 Protective groups SG which can be used are all the conventional protective groups which are known to the skilled worker from peptide synthesis and are also described in the abovementioned standard works. Elimination of the protective groups to give the compounds of the formula V, X and I likewise takes place under conditions known to the 5 skilled worker and described, for example, by Greene and Wuts in "Protective Groups in Organic Synthesis", 2nd Edition, Wiley & Sons, 1991. SG3 and SG5 are so-called N-terminal amino protective groups; preferred for this are Boc, Fmoc, benzyloxycarbonyl (Z), acetyl, Mtr. 0 SG1, SG2 and SG4 are suitable C-terminal hydroxyl protective groups, preferably C-C 4 alkyl such as, for example, methyl, ethyl, tert-butyl, or else benzyl or trityl or else especially for SG1 - polymer-bound protective groups in the form of the commercially available polystyrene resins such as, for example, 2-chlorotrityl-chloride-resin or Wang 5 resin (from Bachem or Novabiochem). Elimination of acid-labile protective groups (for example Boc, tert-butyl, Mtr, trityl) can take place - depending on the protective group used - with organic acids such as trifluoroacetic acid (TFA), trichloroacetic acid, trifluoroethanol or else inorganic acids 0 such as perchloric acid, hydrochloric acid or sulfuric acid, sulfonic acids such as benzene- or p-toluenesulfonic acid, the acids generally being employed in excess. In the case of trityl, addition of thiols such as, for example, thioanisole, ethanedithiol or thiophenol may be advantageous. The presence of an additional inert solvent is possible but not always necessary. Suitable and preferred inert solvents are organic solvents, for 5 example carboxylic acids such as acetic acid; ethers such as THF or dioxane; amides such as DMF or dimethylacetamide; halogenated hydrocarbons such as dichloro methane; alcohols such as methanol, isopropanol; or water. Mixtures of the solvents mentioned are also suitable. The temperature for these reactions is between -1 0*C and 500C, preferably in a range between 00C and 300C. D Base-labile protective groups such as Fmoc are cleaved by treatment with organic amines such as dimethylamine, diethylamine, morpholine, piperidine as 5-50% solutions in CH 2
CI
2 or DMF. The temperature for these reactions is between -10*C and 500C, preferably in a range between 00C and 300C. Acid protective groups such as methyl or ethyl are preferably cleaved by basic hydrolysis in an inert solvent. The bases used are preferably alkali metal or alkaline earth metal - 303 hydroxides, preferably NaOH, KOH or LiOH; the solvents used are all conventional inert solvents such as, for example, hydrocarbons such as hexane, heptane, petroleum ether, toluene, benzene or xylene; chlorinated hydrocarbons such as trichloroethylene, 1,2 dichloroethane, tetrachloromethane, chloroform, dichloromethane; alcohols such as 5 methanol, ethanol, isopropanol, n-propanol, n-butanol or tert-butanol; ethers such as diethyl ether, methyl tert-butyl ether, diisopropyl ether, tetrahydrofuran, dioxane; glycol ethers such as ethylene glycol monomethyl ether or monoethyl ether, ethylene glycol dimethyl ether; ketones such as acetone, butanone; amides such as dimethylformamide (DMF), dimethylacetamide or acetamide; nitriles such as acetonitrile; sulfoxides such as 0 dimethyl sulfoxide; nitro compounds such as nitromethane or nitrobenzene; water or mixtures of the solvents mentioned. The addition of a phase transfer catalyst may be advantageous, depending on the solvent or solvent mixture used. The temperature for these reactions is generally between -10C and 100C. 5 Protective groups which can be eliminated by hydrogenolysis, such as benzyloxy carbonyl (Z) or benzyl, can be eliminated for example by hydrogenolysis in the presence of a catalyst (for example of a noble metal catalyst on active carbon as support). Suitable solvents are those indicated above, in particular alcohols such as methanol, ethanol; amides such as DMF or dimethylacetamide; esters such as ethyl acetate. The 0 hydrogenolysis is usually carried out under a pressure of 1-200 bar and at temperatures between 0* and 1000C; the addition of an acid such as, for example, acetic acid or hydrochloric acid may be advantageous. The catalyst preferably used is 5-10% Pd on active carbon.
- 304 > 0 C 1:Th U, TI/ 00 U, 0 0 0 H 0-a 0 00 0 U, Z a) %' -C 0 - 305 0 00 0=0 CY) 01-44 0 H 0 >4 04 -zc - 306 0 4:D =4: 0 U)0 2Z
UZ
04 0 a0
E)
-307 The compounds of the formula II, lli and VIII, and the starting materials for preparing them can either be bought or be prepared by known methods. Thus, for example, P-aryl- and hetarylamino acids can be synthesized by the method of Johnson et al., J. Am. Chem. Soc. 299, 1936, or Edwards et al., J. Org. Chem. 1979, 44, 5 3136-3140, from an aryl or hetaryl aldehyde, malonic acid and ammonium acetate. Cole describes the synthesis of B-amino acids generally in Tetrahedron 1994, 50, 9517 9582. A method for the enantioselective synthesis of 1-amino acids is described, for example, by Enders, Angew. Chem. Int. Ed. Engl., 1995, 34, 455-457. The preparation D of enantiomerically pure 3-pyridinyl-B-alanine is described by Rico et al., J. Org. Chem., 1993, 58, 7948-7951. 3-Ethynyl-p-alanine can be prepared by the method of Zablocki et al., J. Med. Chem. 1995, 38, 2378-2394. Suitable diaminopropionic acid derivatives can likewise be bought or can be prepared simply as described in WO 97/37655. 5 Conversion of the free p-amino acids or diaminopropionic acid derivatives into the corresponding N- or C-terminally protected derivatives can be carried out by conventional methods of organic chemistry as described, for example, by Bodanszky or Greene in the standard works mentioned. ) Aminohetarylcarboxylic acids and aminohetarylcarboxylic esters of the general formula: N Q OH or HN kQ.
SG
4 or SGs*. N OW 7YOH 0 oo 4o 0 XI XII XV-a which are used as starting materials in the synthesis of compounds of the formula I can 5 either be bought or be prepared in accordance with the following examples: ethyl 2-amino-1,3-thiazole-5-carboxylate in Kushner et al., J. Org. Chem. 1948, 13, 834 et seq.; methyl 2-amino-4-pyridinecarboxylate in Podany et al., J. Org. Chem. 1986, 51, 2988-2994; methyl 5-amino-3-pyridinecarboxylate in Hawkins et al., J. Org. Chem. 1949, ) 14, 328-332; methyl 4-amino-2-pyrimidinecarboxylate in DE 2848912, methyl 6-amino-4 pyrimidinecarboxylate in Zh. Org. Khim. 1981, 17, 312-317; ethyl 5-amino-1,3-thiazole-2 carboxylate in Adams et al., J. Chem. Soc. 1956, 1870-1873; methyl 4-(aminomethyl)-2 thiophenecarboxylate in Peschke et al., Bioorg. Med. Chem. Lett. 1997, 7, 1969-1972; 2 amino-1,3-oxazole-4-carboxylic acid in Foulis et al., J. Med. Chem. 1971, 14, 1075-1077; - 308 methyl 4-aminopyridine-2-carboxylate in Mostier et al., J. Org. Chem. 1955, 20, 283-285; methyl 2-aminopyrimidine-3-carboxylate in Liebigs Ann. Chem. 1965, 209-211; 5-amino 1,3,4-thiadiazole-5-carboxylic acid in Liebigs Ann. Chim.[sic] 1963, 3; 5-amino-1,3,4 triazole-5-carboxylic acid in US 3023210; 4-aminopyrrole-2-carboxylic acid in J. Med. 5 Chem. 1983, 26, 1042; 1-methyl-3-aminopyrazole-5-carboxylic acid in Acta Chem. Scand. 1990, 44, 74; 1-methyl-5-aminopyrazole-3-carboxylic acid in Lee et al., J. Org. Chem. 1989, 54, 428. Conversion of aminohetarylcarboxylic acids or aminohetarylcarboxylic esters of the 0 general formula: N" ,W O H- Akf% N Q O or N Q O'SG 4 XI XII 5 into compounds of the general formula: AsvI f '.% OH A- Nhfe411f : o,'SG -Q Kry N Q"'Y SG 4 o or 0 XIII XIV can take place by methods known to the skilled worker, as described, for example, in 0 WO 97/08145. These building blocks can then be reacted either directly - in the case of the corresponding free carboxylic acids - or after elimination of the protective group SG4 with compounds of the general formula V to give VII (Scheme 1) or with VIII to give IX (for Y = OH, compound VI corresponds to compound XIII). 5 Schemes 4-7 describe by way of example a number of methods for introducing A, the reaction conditions used in each case being those known and suitable for the particular reactions. It is moreover possible to make use of variants which are known per se but which are not mentioned here.
-309 Ureas and thioureas (AE-1 to AE-3) can be prepared by conventional methods of organic chemistry, for example as depicted in Scheme 4, by reacting an isocyanate or an thioisocyanate [sic] with an amine, where appropriate in an inert solvent at elevated temperature (Houben-Weyl, volume Vill, 157 et seq.). 5 Scheme 5 shows by way of example the preparation of compounds of the type AE-4 as described, for example, by Blakemoore et al. in Eur. J. Med. Chem. 1987 (22), 2, 91 100, or by Misra et al. in Bioorg. Med. Chem. Lett. 1994, 4 (18), 2165-2170. D Unsubstituted or cyclic guanidine derivatives of the general formula AE-5 and AE-6 can be prepared using reagents which can be bought or can easily be obtained, as described, for example, in Synlett 1990, 745, J. Org. Chem. 1992, 57, 2497, Bioorg. Med. Chem. 1996, 6, 1185-1208; Bioorg. Med. Chem. 1998, 1185, or Synth. Comm. 1998, 28, 741-746. 5 It is possible to prepare compounds of the general formula AE-7 in analogy to US 3,202,660, and compounds of the formula AE-9, AE-10, AE-1 1 and AE-12 in analogy to WO 97/08145. Compounds of the formula AE-8 can be prepared as shown in Scheme 6, for example by the method described by Perkins et al., Tetrahedron Lett. 1999, 40, 3 103-1106. Scheme 6 gives an overview of the synthesis of the compounds mentioned. Compounds of the general formula AE-13 can be prepared in analogy to Froeyen et al., Phosphorus Sulfur Silicon Relat. Elem. 1991, 63, 283-293, and AE-14 in analogy to Yoneda et al., Heterocycles 1998, 15, No. 1, Spec. Issue, 341-344, as depicted in 5 Scheme 7. Corresponding compounds can also be prepared in analogy to WO 97/36859. As shown in Scheme 8, it is also possible alternatively to react compounds of the general formula IX with XV to give compounds of the general formula XVI, which are ) then, after elimination of the protective group SG5, converted into compounds of type VIll by the methods shown in WO 97/08145 and Schemes 2-5. In the case where R' is Cl-C 4 -alkoxy or benzyloxy, the compounds of the general formula Vill correspond directly to the compounds of type I.
-310 0) 0 Of Of I o4 0I 0 0 I 00 I I, z Ofa 1 a -ul N w _+ EN C)UU I.U
-
-311 00 I I o.:: 0 0 0 r-c-q + C Ln r-'I -312 0 0 0 oo -1 0 0 0 II a & o T I " LU 0 LU ii zt 0 x 0 S - + +a Z II. -ZZ z z C; 0 z O 0 z 0 N ZZ + + 1 +. (A Z E( i- -313 o L) 0 L 0 NN I I 0 Nx z z Im U)) z C.) z0 C,,Y +. L) T 0 0 m . CN z L) I
U))
-314 cn Co 0 0 c IIY o r C.) Y 0 eqe (3x 0 0+ 0) 0 U, z
U)~
-315 U2 0 CIQ 0 -VV 0u.~ 0 cjEn -316 The invention also relates to pharmaceutical preparations for oral and parenteral use containing at least one compound of the formula I in addition to conventional pharmaceutical excipients. The compounds according to the invention can be administered orally or parenterally (subcutaneously, intravenously, intramuscularly, intraperitoneally) in a conventional way. Administration can also take place with vapors or sprays through the nasopharyngeal space. The dosage depends on the age, condition and weight of the patient and on the mode of administration. The daily dose of active ingredient is usually between about 0.5 and 50 mg/kg of bodyweight on oral administration and between about 0.1 and 10 mg/kg of bodyweight on parenteral administration. The novel compounds can be used in conventional solid or liquid pharmaceutical forms, for example as uncoated or (film-)coated tablets, capsules, powders, granules, suppositories, solutions, ointments, creams or sprays. These are produced in a conventional way. The active ingredients can for this purpose be processed with conventional pharmaceutical excipients such as tablet binders, bulking agents, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, release-slowing agents, antioxidants and/or propellant gases (cf. H. Sucker et al.: Pharmazeutische Technologie, Thieme-Verlag, Stuttgart, 1991). The administration forms obtained in this way normally contain the active ingredient in an amount of from 0.1 to 90% by weight. The invention further relates to the use of compounds of the formula I for producing drugs for treating diseases. The compounds of the formula I can be used for treating human and animal diseases. The compounds of the formula I bind to integrin receptors and can thus be used as integrin receptor antagonists and for producing drugs for ) treating diseases in which an integrin receptor is involved. The compounds of the formula I preferentially bind to the avP3 integrin receptor and can thus preferably be used as antagonists of the av@33 integrin receptor and for treating diseases in which the aVP 3 integrin receptor is involved. The compounds of the formula I are preferably used for the treatment of the following diseases: -317 cardiovascular disorders such as atherosclerosis, restenosis after vessel injury and angioplasty (neointima formation, smooth muscle cell migration and proliferation), acute kidney failure, angiogenesis-associated microangiopathies such as, for example, diabetic angiopathies or retinopathy or rheumatoid arthritis, vascular occlusion mediated by blood platelets, arterial thrombosis, stroke, reperfusion damage after myocardial infarct or stroke, cancers such as, for example, in tumor metastasis or tumor growth (tumor-induced angiogenesis), osteoporosis (bone resorption after chemotaxis and adhesion of osteoclasts to bone matrix), high blood pressure, psoriasis, hyperparathyroism [sic], Paget's disease, malignant hypercalcemia, metastatic osteolytic lesions, inflammation, wound healing, cardiac insufficiency, congestive heart failure CHF, and for antiviral, antiparasitic or antibacterial therapy and prophylaxis (adhesion and internalization). The compounds of the formula I can advantageously be administered in combination with at least one other compound in order to achieve an improved curative effect for a number of indications. These other compounds may have the same or a different mechanism of action as the compounds of the formula 1. The pharmaceutical preparations may therefore comprise, besides the compounds of the formula I and the conventional pharmaceutical excipients, at least one other compound depending on the indication selected in each case from one of the following 10 groups.
- 318 Group 1: inhibitors of blood platelet adhesion, activation or aggregation, such as, for example, acetylsalicylic acid, lysine acetylsalicylate, pilacetym [sic], dipyridamole, abciximab, thromboxane antagonists, fibrinogen antagonists, such as, for example, tirofiban, or 5 inhibitors of ADP-induced aggregation such as, for example, ticlopidine or clopidogrel, anticoagulants which prevent thrombin activity or formation, such as, for example, inhibitors of Ila, Xa, Xla, IXa or VIla, antagonists of blood platelet-activating compounds and selectin antagonists for treating blood leaf-mediated [sic] vascular occulsion or thrombosis, or group 2: inhibitors of blood platelet activation or aggregation, such as, for example, GPIlb/Illa antagonists, thrombin inhibitors or factor Xa inhibitors or ADP receptor antagonists, serine protease inhibitors, fibrinogen-reducing compounds, selectin antagonists, antagonists of ICAM-1 or VCAM-1 inhibitors of leukocyte adhesion inhibitors of vessel wall transmigration, fibrinolysis-modulating compounds such as, for example, streptokinase, tPA, plasminogen activation stimulants, TAFI inhibitors, Xla inhibitors or PAl-1 antagonists, inhibitors of complement factors, endothelin receptor antagonists, tyrosine kinase inhibitors, antioxidants and interleukin 8 antagonists for treating myocardial infarct or stroke, or group 3: endothelin antagonists, ACE inhibitors, angiotensin receptor antagonists, endopeptidase inhibitors, beta blockers, -319 calcium channel blockers, phosphodiesterase inhibitors and caspase inhibitors 5 for treating congestive heart failure, or group 4: thrombin inhibitors, inhibitors of factor Xa, 3 inhibitors of the coagulation pathway which leads to thrombin formation, such as, for example, heparin or low molecular weight heparins, inhibitors of blood platelet adhesion, activation or aggregation, such as, for example, GPIlb-Illa antagonists or antagonists of the blood platelet adhesion and activation mediated by vWF or GPlb, 5 endothelin receptor antagonists, nitric oxide synthase inhibitors, CD44 antagonists, selectin antagonists, MCP-1 antagonists, ) inhibitors of signal transduction in proliferating cells, antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF and antioxidants for treating restenosis after vessel injury or stent implantation, or 5 group 5: antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF, heparin or low molecular weight heparins or other GAGs, inhibitors of MMPs, 3 selectin antagonists, endothelin antagonists, ACE inhibitors, angiotensin receptor antagonists and glycosilation [sic] inhibitors or AGE formation inhibitors and antagonists of your [sic] 5 receptors, such as, for example, RAGE, for treating diabetic angiopathies, or - 320 group 6: lipid-lowering compounds, selectin antagonists, antagonists of ICAM-1 or VCAM-1 heparin or low molecular weight heparins or other GAGs, inhibitors of MMPs, endothelin antagonists, apolipoprotein Al antagonists, cholesterol antagonists, HMG-CoA reductase inhibitors, ACAT inhibitors, ACE inhibitors, angiotensin receptor antagonists, tyrosine kinase inhibitors, protein kinase C inhibitors, calcium channel blockers, LDL receptor function stimulants, antioxidants and free radical scavengers for treating atherosclerosis, or group 7: cytostatic or antineoplastic compounds, compounds which inhibit proliferation, such as, for example, kinase inhibitors and heparin or low molecular weight heparins or other GAGs for treating cancer, preferably for inhibiting tumor growth or metastasis, or group 8: compounds for antiresorptive therapy, compounds for hormone replacement therapy, such as, for example, estrogen or progesterone antagonists, recombinant human growth hormone, bisphosphonates such as, for example, alendronates compounds for calcitonin therapy, - 321 calcitonin stimulants, calcium channel blockers, bone formation stimulants, such as, for example growth factor antagonists, interleukin-6 antagonists and Src tyrosine kinase inhibitors for treating osteoporosis, or group 9: TNF antagonists, antagonists of VLA-4 or VCAM-1, antagonists of LFA-1, Mac-1 or ICAMs, complement inhibitors, immunosuppressants, interleukin-1, -5 or -8 antagonists and dihydrofolate reductase inhibitors for treating rheumatoid arthritis, or ) group 10: collagenase, PDGF antagonists and MMPs for improved wound healing. 5 A pharmaceutical preparations [sic] comprising at least one compound of the formula I, where appropriate pharmaceutical excipients and at least one other compound selected in each case from one of the groups above, depending on the indication, means a combined administration of at least one of the compounds of the formula 1 [sic] with at D least one other compound selected in each case from one of the groups described above and, where appropriate, pharmaceutical excipients. The combined administration can take place through a mixture of substances comprising at least one compound of the formula 1, where appropriate pharmaceutical excipients 5 and at least one other compound selected in each case from one of the groups above, depending on the indication, but also spatially and/or temporally separately.
-322 On spatially and/or temporally separate administration, the components of the pharmaceutical preparation, the compounds of the formula 1 [sic] and the compounds selected from one of the aforementioned groups are administered spatially and/or temporally separately. For treatment of restenosis after vessel injury or stenting, the compounds of the formula I can be administered alone or in combination with at least one compound selected from group 4 locally on the affected sites. It may also be advantageous to coat the stents with these compounds. For treatment of osteoporosis, it may be advantageous to administer the compounds of the formula I in combination with an antiresorptive or hormone replacement therapy. The invention accordingly relates to the use of the aforementioned pharmaceutical preparations for producing drugs for treating diseases. In a preferred embodiment, the invention relates to the use of the aforementioned combined pharmaceutical preparations for producing drugs for treating blood platelet-mediated vascular occlusion or thrombosis on use of compounds of group 1, myocardial infarct or stroke on use of compounds of group 2, congestive heart failure on use of compounds of group 3, restenosis after vessel injury on use of compounds of group 4, diabetic angiopathies on use of compounds of group 5, atherosclerosis on use of compounds of group 6, - 323 cancer on use of compounds of group 7, osteoporosis 5 on use of compounds of group 8, rheumatoid arthritis on use of compounds of group 9, 0 wound healing on use of compounds of group 10. The following examples illustrate the invention, the selection of these examples being non-limiting. 5 1. Synthesis Examples L.A Precursors Preparation of the building blocks L D 3-(4-Methylphenyl)-f3-alanine 4-Methylbenzaldehyde (30 g, 0.25 mol) was introduced into 500 ml of ethanol and, after addition of malonic acid (25.9 g, 0.25 mol) and ammonium acetate (28.8 g, 0.374 mol), the mixture was refluxed for 8 h. After the reaction was complete, the mixture was 5 cooled to 50C and the resulting precipitate was filtered off with suction, washed with cold ethanol and diethyl ether and dried in an oven at 400C. 19.9 g; ESI-MS [M+H*] = 180. Fmoc-3-(4-Methylphenyl)-p-alanine 3-(4-Methylphenyl)-p-alanine 1 (7 g, 39.6 mmol) were [sic] dissolved in a mixture of 160 ) ml of aqueous 10% Na 2
CO
3 solution and 50 ml of THF. Then Fmoc-Cl (10.31 g, 39.8 mmol) - dissolved in 40 ml of THF - was added, and the mixture was stirred at room temperature overnight. The reaction mixture was worked up by adjusting to pH 2 with concentrated HCI and extracting twice with diethyl ether. The combined organic phases were then dried (Na 2
SO
4 ) and concentrated, and the remaining residue was crystallized 5 from diethyl ether/cyclohexane and dried. 14 g of a white solid were obtained in this way. ESI-MS [M+H*] = 402 - 324 Preparation of building blocks A-E Ethyl 2-{[(benzylamino)carbonyl]amino}-1,3-thiazole-4-carboxylate Ethyl 2-amino-1,3-thiazolecarboxylate (1.6 g, 9.82 mmol) and benzyl isocyanate (1.31 g, 9.83 mmol) were refluxed in 10 ml of CH 2
CI
2 for 7 h. After the reaction was complete, the mixture was concentrated. Chromatography of the resulting residue on silica gel
(CH
2 Cl 2
/CH
3 0H 2%) afforded 2.4 g of the compound. 2-{[(Benzylamino)carbonyl]amino}-1,3-thiazole-4-carboxylic acid Ethyl 2-{[(benzylamino)carbonyl]amino}-1,3-thiazole-4-carboxylate (2.4 g, 7.86 mmol) was suspended in 10 ml of CH 3 0H and 1 ml of H 2 0 and, after addition of LiOH (0.18 g, 7.86 mmol), stirred at room temperature for 18 h. After the reaction was complete, 20 ml of H 2 0 were added, the pH was adjusted to 1 with concentrated HCI and the resulting solid was filtered off with suction and dried. 1.3 g; ESI-MS [M+H*] = 278 Ethyl (2-{[(benzylamino)carbonyl]aminol-1,3-thiazol-4-yl)acetate The reaction took place analogously with ethyl 2-amino-1,3-thiazol-4-ylacetate (1.25 g, 9.39 mmol). 2.8 g of the compound were obtained after chromatography. (2-{[(Benzylam ino)carbonyl]am ino}-1,3-th iazol-4-yl)-acetic acid The reaction took place analogously from ethyl (2-{[(benzylamino)carbonyl]amino}-1,3 thiazol-4-yl)acetate (2.8 g, 8.77 mmol) and afforded 1.9 g of the compound as a white solid; ESI-MS [M+H*] = 292. 2-{[(Benzylamino)carbonyl]amino}-1,3-oxazole-5-carboxylic acid a) Methyl chloroacetate (32.6 g, 0.30 mol) and methyl formate (25.2 g, 0.42 mol) dissolved in ether (300 ml) were added dropwise to a cooled (0 to 10 C) solution of potassium ethanolate (29.9 g, 0.32 mol) in 80 ml of ethanol. The resulting suspension was stirred at 5 0 C for 1.5 h and at room temperature for 12 h. The resulting salt was filtered off and washed with diethyl ether. The residue was dissolved in H 2 0, acidified to pH 3 with HCI (10 N) at 40C and extracted with diethyl ether. The combined organic fractions were dried, filtered and evaporated to dryness; 12.7 g.
- 325 b) Ethyl formylchloroacetate (10.0 g, 66.42 mmol) and urea (4.4 g, 73.97 mmol) were refluxed [lacuna] 60 ml of H 2 0 for 3.5 h. After the reaction was complete, the mixture was filtered and the filtrate was concentrated. Chromatography (MPLC, RP, Chromasil 100 C18, gradient 1 to 11% acetonitrile) of the resulting residue 5 afforded 0.66 g of the compound. c) Ethyl 2-amino- 1,3-oxazole-5-carboxylate (0.3 g, 1.92 mmol) and benzyl isocyanate (0.26 g, 1.92 mmol) were refluxed in 15 ml of toluene for 8 h. After the reaction was complete, the mixture was washed with water (15 ml), extracted with 5% citric acid 0 (2 x 15 m [sic]) and shaken with H 2 0. The organic phase was dried and concentrated. A mixture (1.27 g) of benzylamine, dibenzylurea and required product (25% purity) precipitates from ethyl acetate and was reacted without further purification. 5 d) Ethyl 2-{[(benzylamino)carbonyl]amino}-1,3-oxazole- 5-carboxylate (0.35 g, 25% purity) was suspended in 20 ml of CH 3 0H and 20 ml of H 2 0 and, after addition of NaOH (1 N, 2.56 mmol), stirred at 350C for 6 h. After the reaction was complete, the mixture was concentrated and the aqueous phase was acidified to pH 2 with HCI (2 N) and exhaustively extracted with ethyl acetate. The combined organic 0 phases were dried, filtered and concentrated. Stirring in acetonitrile afforded 136 mg of the compound; ESI-MS [M+H+] = 262.05. 2-{[(Benzylamino)carbonyl]amino}-1,3-oxazole-4-carboxylic acid 5 a) Bromoethyl pyruvate (59.7 g, 0.306 mol) and urea (27.6 g, 0.46 mol) were refluxed in 220 ml of ethanol for 24 h. The mixture was evaporated, and the remaining residue was mixed with 20 ml of H 2 0, adjusted to pH 10 with 1 N NaOH solution and extracted with CH 2 Cl 2 . Concentration of the organic phases and trituration of the residue with diethyl ether afforded 12.3 g of the free base; 3 ESI-MS [M+H+] = 157.05. Ethereal HCI was added to the mother liquor at 100C. This resulted in a further 11.4 g of the ester as hydrochloride. 5 b) 4 g of ethyl 2-amino-1,3-oxazole-4-carboxylate were refluxed with benzyl isocyanate (3.75 g; 0.13 mmol) and 3.3 g of diisopropylethylamine in 60 ml of toluene for 1 h. After the reaction was complete, the mixture was evaporated, and - 326 the residue was taken up in CH 2 Cl 2 and washed with 1 N HCI and saturated NaCI solutions. Drying the organic phase, concentration and trituration of the residue in methyl tert-butyl ether afforded 4.6 g of white solid; ESI-MS [M+H*] = 290.05. c) 4.3 g of ethyl 2-{[(benzylamino)carbonyl]amino}-1,3-oxazole- 4-carboxylate in 120 ml of 2:1 dioxane/H 2 0 were mixed with 1.4 g of KOH and refluxed for 2 h. Concentration of the mixture and acidification with 2N HCI afforded a white precipitate which was filtered off with suction, washed with acetone and dried. 3.38 g; ESI-MS [M+H+] = 262.05. 4-{[(Benzylamino)carbonyl]aminol-1-methyl-1 H-pyrrole-2-carboxylic acid Methyl 4-amino-1 -methylpyrrole-2-carboxylate (4 g, 26 mmol) were [sic] suspended in 40 ml of toluene and 70 ml of THF, and 1 eq of benzyl isocyanate as solution in 10 ml of THF was added. The mixture was stirred overnight and the resulting precipitate was filtered off. The mother liquor was concentrated, the remaining oil was mixed with diethyl ether, and the resulting precipitate was filtered off. Combining the precipitates afforded 5.16 g; ESI-MS: M+H+ = 288 7.18 g (25 mmol) of the methyl ester were dissolved in 150 ml of THF, and 2 eq of LiOH dissolved in water were added. The mixture was stirred at room temperature for 3 h. It was then neutralized, concentrated and acidified with HCI, and the white precipitate was filtered off with suction. Washing with H 2 0 and crystallization from about 100 ml of ethanol afforded 3.90 g; ESI-MS: M+H* = 274.0. 5-{[(Benzylamino)carbonyl]amino}thiophene-2-carboxylic acid a) 7.76 ml of thionyl chloride at 0 0 C were added dropwise to 85 ml of methanol at 0*C. 16.8 g (97 mmol) of 2-nitrothiophene-5-carboxylic acid were added in portions to this mixture, which was then stirred at room temperature for 5 h. It were [sic] then stirred at 40 0 C for 6 h. After cooling, the mixture was mixed with ice-water, and the precipitate was filtered off, washed with water and taken up in ethyl acetate. The phases were separated, and the organic phase was washed 4x with water, dried with Na 2 SO4 [sic] and concentrated (16.45 g). b) 9.2 g (49 mmol) of methyl 2-nitrothiophene-5-carboxylate were dissolved in 600 ml of glacial acetic acid and, at 40 0 C, 27.45 g of iron powder (Merck, Fe by reduction) - 327 were added in portions. After several hours, the solid was filtered off with suction and washed with glacial acetic acid, ethyl acetate and dichloromethane. The filtrates were combined, dried with Na 2
SO
4 and concentrated. The oily residue was taken up in diethyl ether, and the hydrochloride was precipitated with 6N 5 isopropanolic HCI. Filtration with suction and drying afforded 5.80 g. c) 5.80 g (30 mmol) of the aminothiophene were introduced into 50 ml of toluene with 10.2 mi of diisopropylethylamine and 85 ml of THF. After addition of 1 eq of benzyl isocyanate, the mixture was stirred overnight and then refluxed for about 13 h, and 0 the black solution was concentrated, taken up in ethyl acetate and extracted with 1N HCI, water and saturated NaHCO 3 solution. The aqueous phases were discarded. The resulting precipitate was filtered off, and the mother liquor was dried with Na 2
SO
4 and concentrated to 20 ml. The resulting precipitate was filtered off and washed with cold ethyl acetate. 6.70 g; ESI-MS: M+H* = 291.0. 5 d) 6.6 g (22.8 mmol) of the methyl ester were dissolved in 150 ml of THF, and 1.1 g of LiOH dissolved in water were added. After 3 h, a further 0.55 g of LiOH was added, and the mixture was stirred at 60*C for 16 h. After concentration and extraction of the residue with ethyl acetate, the aqueous phase is [sic] decolorized 0 with activated carbon and acidified with HCl, and the precipitated product was filtered off. 4.5 g remained after drying; ESI-MS: M+H+ = 277.0. 5-{[(Benzylamino)carbonyl]amino}-4H-1,2,4-triazole-3-carboxylic acid 5 a) 100 ml of methanol were mixed with 10.9 ml of thionyl chloride at 00C and then, at room temperature, 12.81 g (100 mmol) of 1,2,4-triazole-5-carboxylic acid hemihydrate were added. The reaction mixture was stirred at room temperature for 16 h, concentrated and mixed with 100 ml of saturated NaHCO 3 solution. The voluminous precipitate was filtered off with suction, freed of ethyl acetate in vacuo D and recrystallized from 200 ml of water. 10.51 g; ESI-MS: M+H+ = 143.0. b) 10.35 g (72.9 mmol) of the aminotriazole were dissolved in 350 ml of toluene, 16 ml of diisopropylethylamine and 85 ml of THF and, after addition of 1.11 eq of benzyl isocyanate, the mixture was refluxed for 5 h. The solution was concentrated 5 and taken up in ethyl acetate, and the organic phase was extracted with 1 N hydrochloric acid, H 2 0 (2x), saturated NaHCO 3 solution and H 2 0 (2x). The organic - 328 phase was dried with Na 2
SO
4 and concentrated, and the residue was triturated with diethyl ether. 15.7 g; ESI-MS [M+H+] = 276.1. c) 15.42 g (56.1 mmol) of the methyl triazolecarboxylate were dissolved in 360 ml of 5 THF and then 2.55 g of LiOH in 250 ml of water were added. After 4 h, the mixture was concentrated, mixed with ethyl acetate and acidified with HCI, and the organic phase was extracted with water, saturated NaHCO 3 solution and water. The precipitated product was filtered off with suction and dried. 1.50 g; ESI-MS [M+H+] = 262.0. 0 4-{[(Benzylamino)carbonyl]amino}thiophene-2-carboxylic acid a) 19.24 g of thionyl chloride were added dropwise to 160 ml of methanol at 00C, and then 25.45 g (147 mmol) of 2-nitrothiophene-4-carboxylic acid were added in 5 portions. The mixture was stirred at 450C for 4.5 h. After cooling, 160 ml of water were added, and, the resulting precipitate was filtered off with suction. 26.75 g. b) 21.5 g (115 mmol) of the nitrothiophene were introduced into 1.4 I of glacial acetic acid and heated to 400C and 10 eq of iron (Merck, prepared by reduction) were D added in portions. After several hours, the solid was filtered off with suction and washed with glacial acetic acid, ethyl acetate and dichloromethane, the mother liquor was mixed with twice the amount of water and extracted 4x with dichloromethane, and the combined organic phases were dried with Na 2
SO
4 and concentrated. The residue was taken up in diethyl ether and converted into the 5 hydrochloride with 6N isopropanolic HCI. Filtration with suction and drying afforded 13.3 g. 1 H-NMR (d6-DMSO) d (ppm) = 3.75 (s, 3H, OCH 3 ), 6.75, 7.70 (each s, 1H, Ar-H)) c) 20.4 g (105.3 mmol) of the aminothiophene were introduced into 530 ml of toluene, 85 ml of THF and 27.2 g of diisopropylethylamine. Then 14.0 g of benzyl isocyanate were added, and the mixture was stirred at room temperature for 16 h and then under reflux for 3 h. The black solution was concentrated, taken up in ethyl acetate and extracted with 1 N HCl, water and saturated NaHCO 3 solution. The organic phase was dried with Na 2
SO
4 and concentrated, and the residue was triturated with diethyl ether; 21.0 g.
- 329 d) 28 g (96.2 mmol) of the thiophene methyl ester were dissolved in 600 ml of THF, and 4.62 g of LiOH in 350 ml of water were added. After 3 h at 600C, the THF was removed in vacuo and the aqueous residue was extracted 2x with ethyl acetate. The aqueous phase was acidified with hydrochloric acid, and the precipitated 5 product was filtered off with suction. For purification, it was taken up in NaOH solution, treated with activated carbon and filtered off with suction through Celite. Acidification with HCI, filtration with suction and drying afforded 20.0 g; ESI-MS: [M+H+]= 277.0. D 5-{[(Benzylamino)carbonyl]amino}-2-furancarboxylic acid a) 10 g (70.86 mmol) of methyl 5-aminofuran-2-carboxylate are dissolved in 200 ml of THF, 10.07 g of HOnig base are added and then 18.87 g (141.7 mmol) of benzyl isocyanate are added dropwise. The solution is stirred at 300C for 6 h and 5 then concentrated under high vacuum, and the residue is taken up in ethyl acetate. It is washed with 1 N HCI, water and saturated NaCl solution. The organ. phase is dried and concentrated. The residue is mixed with a little methanol, briefly boiled and cooled in an ice bath. The solid is filtered off with suction, washed with a little cold methanol and dried (14.0 g). ) ESI-MS [M+H*] = 408.15 b) 10.50 g (25.77 mmol) of methyl 5-{bis[(benzylamino)carbonyl]amino-2-furan carboxylate are suspended in 100 ml of THF, and 18.5 g (773 mmol) of LiOH in 100 ml of water are added. The suspension stirs at room temp. for 20 h. Ethyl 5 acetate and water are added to the mixture, and the aqueous phase is separated off and washed twice more with ethyl acetate. The pH is then adjusted to 1 with 10% HCI, and 1 [sic] the precipitated solid is filtered off, washed with water and dried (5.92 g). ESI-MS [M+H*] = 261.05 Examples I.B Synthesis of compounds of the formula I (A-E-G-L) Example 1 5 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)-carbonyl]amino}acetyl)-3-(4 methylphenyl)-P-alanine (1) - 330 1.1 H-[3-(4-Methylphenyl)-$-alanine]trityl-resin 3.0 g of Cl-trityl-resin were suspended in dichloromethane and, after addition of diisopropylethylamine (1.64 ml, 9 mmol) and 3-(4-methylphenyl)-DP-alanine (1.45 g, 3.6 mmol), shaken at RT overnight. Then a further 1.5 ml of diisopropylethylamine 5 and 9 ml of methanol were added, and the mixture was shaken for a further 30 min. The resin was filtered off with suction and washed successively with dimethylformamide, CH 2
CI
2 , CH 3 0H and CH 2
CI
2 . To eliminate the Fmoc protective group, the resin was shaken in 1:1 piperidine/CH 2
C
2 at RT for 20 min, filtered off with suction and washed 5x with CH 2
CI
2 . The protective group cleavage was 0 carried out a total of 2x. The resin was then washed again with dimethylformamide,
CH
2
CI
2 , CH 3 0H and CH 2 Cl 2 and dried in an oven at RT overnight. The final weight was 3.44 g (loading: 0.896 g/mmol). 1.2 H-Gly-[3-(4-Methylphenyl)-f-alanine]-trityl-resin 5 H-[3-(4-Methylphenyl)-B-alanine]-trityl-resin (111.6 mg, 0.1 mmol) was suspended in dimethylformamide and, after addition of Fmoc-Gly-OH (59.5 mg, 0.2 mmol), diisopropylethylamine (34.4 ml, 0.2 mmol) and TBTU (64.4 mg, 0.2 mmol), shaken at room temperature for 48 h. The resin was then filtered off with suction and washed successively with dimethylformamide, CH 2 Cl 2 , CH 3 0H and CH 2
C
2 . To 0 eliminate the Fmoc protective group, the resin was shaken in 1:1 piperidine/CH 2
CI
2 at RT for 20 min, filtered off with suction and washed 5x with CH 2 Cl 2 . The protective group cleavage was carried out a total of 2x. The resin was then washed again with dimethylformamide, CH 2
CI
2 , CH 3 0H and CH 2
CI
2 and dried in an oven at RT overnight. 5 1.3 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)-carbonyl]amino}acetyl)-3 (4-methylphenyl)-p-alanine (1) 0.03 mmol of H-Gly-[3-(4-methylphenyl)-p-alanine]-trityl- resin was suspended in DMF and, after addition of 2-{[(benzylamino)carbonyl]amino}-1,3-thiazole-4 0 carboxylic acid (17.5 mg, 0.06 mmol), diisopropylethylamine (10.32 ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol), shaken at room temperature overnight. The resin was then filtered off with suction and washed successively with dimethylformamide, CH 2
CI
2 , CH 3 OH and CH 2
CI
2 . Then, for cleavage off the resin, 1.5 ml of a 1:1:3 trifluoroethanol/acetic acid/CH 2
C
2 mixture were added and the 5 mixture was again shaken at room temperature for 1 h. Evaporation of the cleavage solution, addition of 2 ml of acetic acid to the residue and lyophilization afforded 5 mg of the required product, ESI-MS [M+H*] = 496.
-331 Example 2 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]-amino}acetyl)-3-(4 methylphenyl)-D-alanine (2) 0.03 mmol of H-Gly-[3-(4-methylphenyl)- P-alanine]-trityl-resin was suspended in DMF and, after addition of (2-{[(benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetic acid (17.5 mg, 0.06 mmol), diisopropylethylamine (10.32 ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol), shaken at room temperature overnight. The resin was then filtered off ) with suction and washed successively with dimethylformamide, CH 2
CI
2 , CH 3 0H and
CH
2 Cl 2 . Then, for cleavage off the resin, 1.5 ml of a 1:1:3 trifluoroethanol/acetic acid/CH 2
C
2 mixture were added and the mixture was again shaken at room temperature for 1 h. Evaporation of the cleavage solution, addition of 2 ml of acetic acid to the residue and lyophilization afforded 8 mg of the required product, ESI-MS [M+H*] = 510. 5 The cleavage solution was then evaporated to dryness, and the residue was taken up in ethyl acetate and lyophilized. Example 3 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)-carbonyl]amino}acetyl)-3-(3 pyridinyl)-B-alanine (3) 3.1 H-[3-(3-Pyridinyl)-p-alanine]-trityl-resin Procedure analogous to the preparation of H-[3-(4-methylphenyl)-p-alanine]-trityl resin. H-Gly-[3-(3-Pyridinyl)-B-alanine]-trityl-resin H-[3-(3-Pyridinyl)- p-alanine]-trityl-resin (106.4 mg, 0.1 mmol) was suspended in dimethylformamide and, after addition of Fmoc-Gly-OH (59.5 mg, 0.2 mmol), diisopropylethylamine (34.4 ml, 0.2 mmol) and TBTU (64.4 mg, 0.2 mmol), shaken at room temperature for 48 h. The resin was filtered off with suction and washed successively with dimethylformamide, CH 2 Cl 2 , CH 3 0H and CH 2 Cl 2 . To eliminate the Fmoc protective group, the resin was shaken in 1:1 piperidine/CH 2
C
2 at RT for 20 min, filtered off with suction and washed 5x with CH 2
CI
2 . The protective group cleavage was carried out a total of 2x. The resin was then washed again with dimethylformamide, CH 2 Cl 2 , CH 3 0H and CH 2
CI
2 and dried in an oven at RT overnight.
- 332 3.2 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)-carbonyl]amino}acetyl)-3 (3-pyridinyl)-s-alanine (3) 0.03 mmol of H-Gly-[3-(3-pyridinyl)-b-alanine]-trityl-resin [sic] was suspended in DMF and, after addition of 2-{[(benzylamino)carbonyl]amino}-1,3-thiazole-4 5 carboxylic acid 4 [sic] (17.5 mg, 0.06 mmol), diisopropylethylamine (10.32 ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol), shaken at room temperature overnight. The resin was' then filtered off with suction and washed successively with dimethylformamide, CH 2
CI
2 , CH 3 0H and CH 2 Cl 2 . Then, for cleavage off the resin, 1.5 ml of a 1:1:3 trifluoroethanol/acetic acid/CH 2
C
2 mixture were added and the 0 mixture was again shaken at room temperature for 1 h. Evaporation of the cleavage solution, addition of 2 ml of acetic acid to the residue and lyophilization afforded 8 mg of the required product, ESI-MS [M+H*] = 483. Example 4 5 N-({[(2-{[(Benzylamino)carbonyl]aminol-1,3-thiazol-4-yl)acetyl]-amino}acetyl)-3-(3 pyridinyl)-B-alanine (4) 0.03 mmol of H-Gly-[3-(3-pyridinyl)-f-alanine]-trityl-resin was suspended in DMF and, after addition of (2-{[(benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetic acid (17.5 mg, 3 0.06 mmol), diisopropylethylamine (10.32 ml, 0.06 mmol) and TBTU (19.32 mg, 0.06 mmol), shaken at room temperature overnight. The resin was then filtered off with suction and washed successively with dimethylformamide, CH 2
CI
2 , CH 3 0H and CH 2 Cl 2 . Then, for cleavage off the resin, 1.5 ml of a 1:1:3 trifluoroethanol/acetic acid/CH 2
CI
2 mixture were added and the mixture was again shaken at room temperature for 1 h. 5 Evaporation of the cleavage solution, addition of 2 ml of acetic acid to the residue and lyophilization afforded 10 mg of the required product, ESI-MS [M+H*] = 497. The following were prepared analogously: N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]aminolacetyl)-3-(3,5 dichlorophenyl)-p-alanine (5) 21 mg; ESI-MS [M+H+] = 550. N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino}acetyl)-3-(2 naphthyl)-o-alanine (6) 15 mg; ESI-MS [M+H+] = 532.
- 333 N-({[(2-{[(Benzylam ino)carbonyl]aminol-1,3-thiazol-4-yl)carbonyl]am ino}acetyl)-3-[1, 1' biphenyl]-4-yl-p-alanine [sic] (7) 22 mg; ESI-MS [M+H+] = 560. 5 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino}acetyl)-3-(2,3 dimethoxyphenyl)-p-alanine (8) 18 mg; ESI-MS [M+H+] = 542. N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino}acetyl)-3-( 1 0 naphthyl)-p-alanine (9) 19 mg; ESI-MS [M+H+] = 532. N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}acetyl)-3-(3,5 dichlorophenyl)-p-alanine (10) 5 42 mg; ESI-MS [M+H+] = 565. N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}acetyl)-3-(2 naphthyl)-o-alanine (11) 44 mg; ESI-MS [M+H+] = 546. 0 N-({[(2-{[(Benzylamino)carbonyl]aminol-1,3-thiazol-4-yl)acetyl]amino}acetyl)-3-[1,1' biphenyl-]-4-ylalanine [sic] (12) 7 mg; ESI-MS [M+H+] = 572. 5 N-({[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)acetyl]amino}acetyl)-3-(2,3 dimethoxyphenyl)-p-alanine (13) 30 mg; ESI-MS [M+H+] = 556. N-({[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)acetyl]amino}acetyl)-3-(1 D naphthyl)-p-alanine (14) 37 mg; ESI-MS [M+H+] = 546. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)acetyl]aminolpropanoyl) 3-(3,5-dichlorophenyl)-5-alanine (15) 5 24 mg; ESI-MS [M+H+] = 579.
- 334 N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}propanoyl) 3-(3-pyridinyl)-P-alanine (16) 7.1 mg; ESI-MS [M+H+] = 511. 5 N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}propanoyl) 3-(2-naphthyl)-p-alanine (17) 17 mg; ESI-MS [M+H+] = 560. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}propanoyl) 3 3-[1,1'-biphenyl]-4-yl-p-alanine [sic] (18) 20 mg; ESI-MS [M+H+] = 586. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]aminolpropanoyl) 3-(2,3-dimethoxyphenyl)-B-alanine (19) 5 16 mg; ESI-MS [M+H+] = 570. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}propanoyl) 3-(1-naphthyl)-5-alanine (20) 16 mg; ESI-MS [M+H+] = 560. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}propanoyl) 3-(4-methylphenyl)-o-alanine (21) 19 mg; ESI-MS [M+H+] = 524. 5 N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino} propanoyl)-3-(3,5-dichlorophenyl)-p-alanine (22) 18.5 mg; ESI-MS [M+H+] = 565. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)carbonyl]amino) propanoyl)-3-(3-pyridinyl)--alanine (23) 4.8 mg; ESI-MS [M+H+] = 497. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)carbonyl]amino) propanoyl)-3-(2-naphthyl)-5-alanine (24) 18.4 mg; ESI-MS [M+H+] = 546.
-335 N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino} propanoyl)-3-[1,1'-biphenyl]-4-yl-p-alanine [sic] (25) 16 mg; ESI-MS [M+H+] = 572. 5 N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino} propanoyl)-3-(2,3-dimethoxyphenyl)-D-alanine (26) 15 mg; ESI-MS [M+H+] = 556. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbony]amino} 0 propanoyl)-3-(1 -naphthyl)-p-alanine (27) 13 mg; ESI-MS [M+H+] = 546. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino} propanoyl)-3-(4-methylphenyl)-D-alanine (28) 5 18 mg; ESI-MS [M+H+] = 510. N-((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]aminolpropanoyl) 3-(4-methylphenyl)-@-alanine (29) 17.2mg; ESI-MS [M+H+] = 510. 0 (2S)-3-[((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)acetyl]amino) propanoyl)amino]-2-{[(benzyloxy)carbonyl]amino}propanoic acid (30) 11.1 mg; ESI-MS [M+H+] = 583. 5 (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}acetyl)amino] 2-{[(benzyloxy)carbonyl]amino}propanoic acid (31) 14.9 mg; ESI-MS [M+H+] = 569. (2S)-3-[((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)carbonyl]amino} D propanoyl)amino]-2-{[(benzyloxy)carbonyl]amino}propanoic acid (32) 6.5 mg; ESI-MS [M+H+] = 569. (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino)-1,3-thiazol-4-yl)carbonyl]amino}acetyl) amino]-2-{[(benzyloxy)carbonyl]aminolpropanoic acid (33) 5 5.9 mg; ESI-MS [M+H+] = 555.
- 336 N-{[[(2-{[(Benzylamino)carbonyl]am ino}-1,3-thiazol-4-yl)acetyl](methyl)amino]acetyl}-3 (3-pyridinyl)-p-alanine (34) 15 mg; [M+H+] = 512. 5 N-{[[(2-{[(Benzylamino)carbonyl]am ino}-1,3-thiazol-4-yl)acetyl](methyl)amino]acetyl}-3 (3,5-dichlorophenyl)-p-alanine (35) 18 mg; [M+H+] = 579. (2R)-3-({[[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl](methyl)amino] D acetyl}amino)-2-{[(benzyloxy)carbonyl]aminoipropanoic acid (36) 14 mg; [M+H+] = 583. (2R)-3-({[(3-{[(Benzylam ino)carbonyl]am ino}benzoyl)am ino]acetyl}am ino)-2 {[(benzyloxy)carbonyl]amino}propanoic acid (37) 5 10 mg; [M+H+] = 548. (2R)-3-({(2S)-2-[(3-{[(Benzylamino)carbonyl]amino}benzoyl)amino]propanoyl}amino)-2 {[(benzyloxy)carbonyl]aminoipropanoic acid (38) 4 mg; [M+H+] = 562. N-{[[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl](methyl)amino]acetyl} 3-(3,5-dichlorophenyl)-p-alanine (39) 16 mg; [M+H+] = 564. N-{[[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl](methyl)aminolacetyl} 3-(3-pyridinyl)-B-alanine (40) 18 mg; [M+H+] = 497. (2R)-3-({[[(2-{[(benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl](methyl)amino] acetyllamino)-2-{[(benzyloxy)carbonyl]aminoipropanoic acid (41) 15 mg; [M+H+] = 569. N-((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]aminolpropanoyl) 3-(3-pyridinyl)-p-alanine (42) 18 mg; ESI-MS [M+H+] = 511.
-337 N-((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}propanoyl) 3-(3,5-dichlorophenyl)-p-alanine (43) 20 mg; ESI-MS [M+H+] = 579. 5 N-((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino} propanoyl)-3-(3,5-dichlorophenyl)-p-alanine (44) 16 mg; ESI-MS [M+H+] = 565. N-((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino} D propanoyl)-3-(3-pyridinyl)-B-alanine (45) 10 mg; ESI-MS [M+H+] = 497. (2S)-3-[((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]amino} propanoyl)amino]-2-{[(benzyloxy)carbonyl]amino}propanoic acid (46) 5 12 mg; ESI-MS [M+H+] = 569. (2S)-3-[((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)acetyl]amino} propanoyl)amino]-2-{[(benzyloxy)carbonyl]amino}propanoic acid (47) 17 mg; ESI-MS [M+H+] = 583. N-{[[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl](methyl)amino]acetyll 3-cyclohexyl-p-alanine (48) 12 mg; ESI-MS [M+H+] = 502. i N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)carbonyl]aminolacetyl)-3-cyclo hexyl-o-alanine (49) 10 mg; ESI-MS [M+H*] = 488. N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-5-yl)carbonyl]amino}acetyl)-3-pyridin 3-yl-beta-alanine (50); ESI-MS [M+H*] = 483. N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-4-yl)carbonyl]amino}acetyl)-3-pyridin 3-yl-beta-alanine (51); ESI-MS [M+H+] = 467.
-338 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-5-yl)carbonyl]amino}acetyl)-3-(2,5 dimethoxyphenyl)-beta-alanine (52); ESI-MS [M+H*] = 542. 5 N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-4-yl)carbonyl]amino}acetyl)-3-(2 naphthyl)-beta-alanine (53); ESI-MS [M+H*] = 516. N-({[(2-{[(Benzylamino)carbonyl]amino)-1,3-oxazol-4-yl)carbonyl]amino}acetyl)-3-(4 0 methylphenyl)-beta-alanine (54); ESI-MS [M+H*] = 480. (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino)-1,3-oxazol-4-yl)carbonyl]amino}acetyl) amino]-2-{[(benzyloxy)carbonyl]amino}propanoic acid (55); 5 ESI-MS [M+H*] = 539. 3-{1-[({[(4-{[(Benzylamino)carbonyl]amino)-1-methyl-1 H-pyrrol-2-yl)carbonyl]amino} acetyl)amino]-2-carboxyethyllpyridinium acetate (56); ESI-MS [M+H*] = 479. 0 N-({[(4-{[(Benzylamino)carbonyl]amino)-1-methyl-1 H-pyrrol-2-yl)carbonylamino}acetyl) 3-(2-naphthyl)-beta-alanine (57); ESI-MS [M+H*] = 528. 5 (2S)-3-[({[(4-{[(Benzylamino)carbonyl]amino)-1-methyl-1 H-pyrrol-2-yl)carbonyl]amino} acetyl)amino]-2-{[(benzyloxy)carbonyl]aminolpropanoic acid (58); ESI-MS [M+H*] = 551. N-({[(4-{[(Benzylamino)carbonyljamino}-1 -methyl-1 H-pyrrol-2-yl)carbonyl]aminolacetyl) 3-[1,1'-biphenyl]-4-yl-beta-alanine [sic] (59); ESI-MS [M+H*] = 554. N-({[(4-{[(Benzylamino)carbonyl]amino)-1-methyl-1 H-pyrrol-2-yl)carbonyl]amino)acetyl) 3-(4-methylphenyl)-beta-alanine (60); i ESI-MS [M+H*] = 492.
- 339 N-({[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2-yl)carbonyl]amino}acetyl) 3-cyclohexyl-beta-alanine (61); ESI-MS [M+H*] = 484. 5 N-{[[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] acetyl}-3-cyclohexyl-beta-alanine (62); ESI-MS [M+H*] = 498. N-{[[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] ) acetyll-3-(3,4-dimethoxyphenyl)-beta-alanine (63); ESI-MS [M+H*] = 552. N-(3-{[(4-{[(Benzylamino)carbonyl]amino}-1-methyl-1 H-pyrrol-2-yl)carbonyl]amino} propanoyl)-3-pyridin-3-yI-beta-alanine (64); 5 ESI-MS [M+H*] = 493. N-(3-{[(4-{[(Benzylamino)carbonyl]aminol}-1 -methyl-1 H-pyrrol-2-yl)carbonyl]aminol propanoyl)-3-(2,5-dimethoxyphenyl)-beta-alanine (65); ESI-MS [M+H*] = 552. N-((2R)-2-{[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2-yl)carbonyl]aminol propanoyl)-3-(4-tert-butylphenyl)-beta-alanine (66); ESI-MS [M+H*] = 548. N-((2R)-2-{[(4-{[(Benzylamino)carbonyl]amino}-i -methyl-1 H-pyrrol-2-yl)carbonyl] aminolpropanoyl)-3-(3,4-dimethoxyphenyl)-beta-alanine (67); ESI-MS [M+H*] = 552. (2S)-3-[({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}acetyl)amino]-2 {[(benzyloxy)carbonyl]aminol-propanoic acid (68); ESI-MS [M+H*] = 554. N-({[(4-{[(Benzylamino)carbonyl]amino}-1-methyl-1 H-pyrrol-2-yl)carbonyl]aminolacetyl) 3-(3,5-dichlorophenyl)-beta-alanine (69); ESI-MS [M+H*] = 546.
- 340 N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyllamino}acetyl)-3-pyridin-3-yl beta-alanine (70); ESI-MS [M+H*] = 482. 5 N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}acetyl)-3-(3,5-dichloro phenyl)-beta-alanine (71); ESI-MS [M+H*] = 549. N-({[(5-{[(Benzylam ino)carbonyl]am ino}thien-2-yl)carbonyl]am ino}acetyl)-3-(4-methyl 0 phenyl)-beta-alanine (72); ESI-MS [M+H*] = 495. (2S)-3-[({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}acetyl)amino]-2 [(phenylsulfonyl)amino]propanoic acid (73); 5 ESI-MS [M+H*] = 560. N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}acetyl)-3-(4-tert-butyl phenyl)-beta-alanine (74); ESI-MS [M+H*] = 537. D 4-[({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}acetyl)amino]-3 {[(benzyloxy)carbonyl]aminolbutanoic acid (75); ESI-MS [M+H*] = 568. 5 N-({[(5-{[(Benzylamino)carbonyl]aminoithien-2-yl)carbonyl]amino}acetyl)-3-cyclohexyl beta-alanine (76); ESI-MS [M+H*] = 487. N-{[[(5-{[(Benzylamino)carbonyl]aminolthien-2-yl)carbonyl](methyl)amino]acetyl)-3-[1,1' biphenyl]-4-yl-beta-alanine [sic] (77); ESI-MS [M+H*] = 571. N-{[[(5-{[(Benzylamino)carbonyl]aminolthien-2-yl)carbonyl](methyl)amino]acetyl)-3-(2,5 dimethoxyphenyl)-beta-alanine (78); ESI-MS [M+H*] = 555.
-341 N-{[[(5-{[(Benzylam ino)carbonyl]am ino}thien-2-yl)carbonyl](methyl)amino]acetyl}-3-(4 methylphenyl)-beta-alanine (79); ESI-MS [M+H*] = 509. 5 (2S)-3-({[[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl](methyl)amino]acetyl} amino)-2-{[(benzyloxy)carbonyl]amino}propanoic acid (80); ESI-MS [M+H*] = 568. N-{[[(5-{[(Benzylam ino)carbonyl]am ino}thien-2-yl)carbonyl](methyl)am ino]acetyl}-3 0 cyclohexyl-beta-alanine (81); ESI-MS [M+H*] = 501. N-{[[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl](methyl)amino]acetyl}-3-(3,4 dimethoxyphenyl)-beta-alanine (82); 5 ESI-MS [M+H*] = 555. 4-({[[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl](methyl)amino]acetyl}amino) 3-{[(benzyloxy)carbonyl]amino}butanoic acid (83); ESI-MS [M+H*] = 582. ) N-(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3-pyridin 3-yl-beta-alanine (84); ESI-MS [M+H*] = 496. 5 N-(3-{[(5-{[(Benzylamino)carbonyllaminolthien-2-yl)carbonyl]amino}propanoyl)-3-(2,5 dimethoxyphenyl)-beta-alanine (85); ESI-MS [M+H*] = 555. (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl) amino]-2-{[(benzyloxy)carbonyl]amino}propanoic acid (86); ESI-MS [M+H*] = 568. N-(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3-cyclo hexyl-beta-alanine (87); ESI-MS [M+H*] = 501.
- 342 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl) amino]-2-[(phenylsulfonyl)amino]propanoic acid (88); ESI-MS [M+H*] = 574. 5 N-(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3-(4-tert butylphenyl)-beta-alanine (89); ESI-MS [M+H*] = 551. N-(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3-(3,4 0 dimethoxyphenyl)-beta-alanine (90); ESI-MS [M+H*] = 555. N-(3-{[(5-{[(Benzylamino)carbonyllaminolthien-2-yl)carbonyl]aminolpropanoyl)-3-(3,4 dimethoxyphenyl)-beta-alanine (91); 5 ESI-MS [M+H*] = 582. N-((2S)-2-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3-(4 tert-butylphenyl)-beta-alanine (92); ESI-MS [M+H*] = 551. N-((2S)-2-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3 (3,4-dimethoxyphenyl)-beta-alanine (93); ESI-MS [M+H*] = 555. 5 N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}acetyl)-3-(2,5 dimethoxyphenyl)-beta-alanine (94); ESI-MS [M+H*] = 541. N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}acetyl)-3-(1 -naphthyl) beta-alanine (95); ESI-MS [M+H*] = 531. N-({[(4-{[(Benzylamino)carbonyl]amino}-1-methyl-1 H-pyrrol-2-yl)carbonyl]amino}acetyl) 3-(3,4-dimethoxyphenyl)-beta-alanine (96); ESI-MS [M+H*] = 538.
- 343 N-{I[[(4-{[(Benzylamino)carbonyl]amino}-1-methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] acetyl}-3-(3,5-dichlorophenyl)-beta-alanine (97); ESI-MS [M+H*] = 560. 5 N-{[[(4-{[(Benzylamino)carbonyl]amino}-l -methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] acetyl}-3-pyridin-3-yl-beta-alanine (98); ESI-MS [M+H*] = 493. N-{[[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] 0 acetyl}-3-(2-naphthyl)-beta-alanine (99); ESI-MS [M+H*] = 542. N-{[[(4-{[(Benzylamino)carbonyl]amino}-1-methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] acetyl}-3-[1,1 '-biphenyl]-4-yl-beta-alanine [sic] (100); 5 ESI-MS [M+H*] = 568. N-{[[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] acetyl}-3-(2,5-dimethoxyphenyl)-beta-alanine (101); ESI-MS [M+H*] = 552. N-{[[(4-{[(Benzylamino)carbonyl]amino}-1-methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] acetyl}-3-(1 -naphthyl)-beta-alanine (102); ESI-MS [M+H*] = 542. N-{[[(4-{[(Benzylamino)carbonyl]amino}-1-methyl-1 H-pyrrol-2-yl)carbonyl](methyl)amino] acetyl}-3-(4-methylphenyl)-beta-alanine (103); ESI-MS [M+H*] = 506. (2S)-3-({[[(4-{[(Benzylamino)carbonyl]amino)-1 -methyl-1 H-pyrrol-2-yl)carbonyl](methyl) amino]acetyl}amino)-2-{[(benzyloxy)carbonyl]amino)propanoic acid (104); ESI-MS [M+H*] = 565. N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino)acetyl)-3-(3,4 dimethoxyphenyl)-beta-alanine (105); ESI-MS [M+H*] = 541.
-344 N-{[[(5-{[(Benzylamino)carbonyl]aminolthien-2-yl)carbonyl](methyl)amino]acetyl}-3 pyridin-3-yi-beta-alanine (106); ESI-MS [M+H*] = 496. 5 N-(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3-(1 naphthyl)-beta-alanine (107); ESI-MS [M+H*] = 545. N-(3-{[(5-{[(Benzylamino)carbonyl]aminolthien-2-yl)carbonyl]amino}propanoyl)-3-(4 3 methylphenyl)-beta-alanine (108); ESI-MS [M+H*] = 509. N-({[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)carbonyl]aminolacetyl)-3-pyridin-3-yl beta-alanine (109); 5 ESI-MS [M+H*] = 482. N-({[(5-{[(Benzylamino)carbonyl]aminolthien-3-yl)carbonyl]amino}acetyl)-3-(3,5-dichloro phenyl)-beta-alanine (110); ESI-MS [M+H*] = 549. N-({[(5-{[(Benzylam ino)carbonyl]am inolthien-3-yl)carbonyl]am ino}acetyl)-3-(4-methyl phenyl)-beta-alanine (111); ESI-MS [M+H*] = 495. (2S)-3-[({[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)carbonyl]aminolacetyl)amino]-2 {[(benzyloxy)carbonyl]aminolpropanoic acid (112); ESI-MS [M+H*] = 554. N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-5-yl)carbonyl]amino}acetyl)-3-pyridin 3-yl-beta-alanine (113); ESI-MS [M+H*] = 467. N-({[(2-{[(Benzylamino)carbonyl]amino)-1,3-oxazol-5-yl)carbonyl]amino}acetyl)-3-(3,5 dichlorophenyl)-beta-alanine (114); ESI-MS [M+H*] = 534.
-345 (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-5-yl)carbonyl]aminolacetyl) amino]-2-{[(benzyloxy)carbonyl]amino)propanoic acid (115); ESI-MS [M+H*] = 539. 5 N-((2R)-2-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3 (3,4-dimethoxyphenyl)-beta-alanine (116); ESI-MS [M+H*] = 555. N-((2R)-2-{[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}propanoyl)-3-(4 D tert-butylphenyl)-beta-alanine (117); ESI-MS [M+H*] = 551. Examples ESI-MS Amount [M+H*] [mq] 118 (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yl)- 575 4 acetyl]amino}acetyl)amino]-2-[(phenylsulfonyl)amino]propanoic acid 119 (2S)-3-[((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3- 589 7 thiazol-4-yl)acetyl]amino}propanoyl)amino]-2-[(phenylsulfonyl) aminolpropanoic acid 120 (2S)-3-[((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3- 589 5 thiazol-4-yl)acetyl]amino}propanoyl)amino]-2-[(phenylsulfonyl) amino]propanoic acid 121 (2S)-3-[(3-{[(2-{[(Benzylamino)carbonyl]aminol-1,3-thiazol-4- 589 2 yl)acetyl]amino}propanoyl)amino]-2-[(phenylsulfonyl)amino] propanoic acid 122 (2S)-3-({[[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4- 589 3 yl)acetyl](methyl)amino]acetyl}amino)-2-[(phenylsulfonyl) amino]propanoic acid 123 (2S)-3-[({[(2-{[(Benzylamino)carbonyljamino}-1,3-thiazol-4-yl)- 561 6 carbonyl]amino)acetyl)aminol-2-[(phenylsulfonyl)amino] propanoic acid 124 (2S)-3-[((2S)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3- 575 6 thiazol-4-yl)carbonyl]amino}propanoyl)amino]-2-[(phenyl sulfonyl)amino]propanoic acid 125 (2S)-3-[((2R)-2-{[(2-{[(Benzylamino)carbonyl]amino}-1,3- 575 8 thiazol-4-yl)carbonyl]amino)propanoyl)amino]- - 346 Examples ESI-MS Amount [M+H*] [mg] 2-[(phenylsulfonyl)aminolpropanoic acid 126 (2S)-3-[(3-{[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4- 575 4 yl)carbonyl]amino)propanoyl)amino]-2-[(phenylsulfonyl)amino] propanoic acid 127 (2S)-3-({[[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4- 575 9 yl)carbonyl](methyl)amino]acetyl}amino)-2-[(phenylsulfonyl) amino]propanoic acid 128 (2S)-3-({[[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)- 574 2 carbonyl](methyl)am ino]acetyl}am ino)-2-[(phenylsulfonyl) amino]propanoic acid 129 (2S)-3-[({[(5-{[(Benzylamino)carbonyljamino}thien-3-y)- 554 1 carbonyl]amino}acetyl)-amino]-2-{[(benzyloxy)carbonyl]amino} propanoic acid 130 (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino)-4-methyl-1,3- 569 1 thiazol-5-yl)carbonyl]amino}acetyl)amino]-2-{[(benzyloxy) carbonyl]amino}propanoic acid 131 (2S)-3-[({[(2-{[(Benzylam ino)carbonyl]am ino}-4-methyl- 1,3- 575 2 thiazol-5-yl)carbonyl]amino}acetyl)amino]-2-[(phenylsulfonyl) _ amino]propanoic acid 132 (2S)-3-[({[(5-{[(Benzyldmino)carbonyl]amino}thien-3-yl)- 560 1 carbonyl]amino}acetyl)amino]-2-[(phenylsulfonyl)amino] propanoic acid 133 (2S)-3-({[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 574 16 carbonyl](methyl)amino]acetyl}amino)-2-[(phenylsulfonyl) amino]propanoic acid 134 (2S)-3-({[[(5-{[(Benzylamino)carbonyl]amino)thien-3-yl)- 568 8 carbonyl](methyl)amino]acetyl}amino)-2-{[(benzyloxy) carbonyl]amino}propanoic acid 135 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 568 6 carbonyl]amino}propanoyl)amino]-2-{[(benzyloxy)carbonyl] amino}propanoic acid 136 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]aminoithien-3-yl)- 574 2 carbonyl]amino}propanoyl)amino]-2-[(phenylsulfonyl)amino] propanoic acid I 137 (2S)-3-({[[(5-{[(Benzylamnino)carbonyl]amino}-1 H-1,2,4-triazol- 559 2 - 347 Examples ESI-MS Amount [M+H*] [mg] 3-yl)carbonyl](methyl)amino]acetyl}am ino)-2-[(phenylsulfonyl) amino]propanoic acid 138 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}-1 H-1,2,4- 559 6 triazol-3-yl)carbonyl]amino}propanoyl)amino-2-[(phenyl sulfonyl)amino]propanoic acid 139 (2S)-3-[({[(5-{[(Benzylamino)carbony]amino}-1H-1,2,4-triazol- 539 7 3-yl)carbonyl]amino}acetyl)amino]-2-{[(benzyloxy)carbonyl] amino}propanoic acid 140 (2S)-3-({[[(5-{[(Benzylamino)carbonyl]amino}-1H-1,2,4-triazol- 553 2 3-yl)carbonyl](methyl)amino]acetyllamino)-2-{[(benzyloxy) carbonyl]amino}propanoic acid 141 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}-1 H-1,2,4- 553 9 triazol-3-yl)carbonyl]aminolpropanoyl)amino]-2-{[(benzyloxy) carbonyl]amino}propanoic acid 142 (2S)-3-({[(5-{[(Benzylamino)carbonyl]amino}-2-furoyl)amino]- 538 14 ____ acetyl}am ino)-2-{[(benzyloxy)carbonyl]am ino}propanoic acid 143 (2S)-3-({[(5-{[(Benzylamino)carbonyl]aminol2-furoyl)(methyl)- 552 8 amino]acetyl}amino)-2-{[(benzyloxy)carbonyl]amino}propanoic ,acid 144 (2S)-3-({3-[(5-{[(Benzylamino)carbonyl]amino}-2-furoyl)amino]- 552 17 propanoyl}am ino)-2-{[(benzyloxy)carbonyl]am ino}propanoic acid 145 (2S)-3-({3-[(5-{[(Benzylamino)carbonyl]amino]-2-furoyl)amino]- 558 4 propanoyl}amino)-2-[(phenylsulfonyl)amino]propanoic acid 146 (2S)-3-[((2S)-2-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 596 16 carbonyl]am ino}-3-methylbutanoyl)am ino]-2-{[(benzyloxy) carbonyl]amino}propanoic acid 147 (2S)-3-[({[(5-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-2-yl)- 555 6 carbonyl]amino}acetyl)amino]-2-{[(benzyloxy)carbonyl] amino}propanoic acid 148 (3R)-4-({[[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H- 579 6 pyrrol-2-yl)carbonyl](m ethyl)am ino]acetyl)amino)-3 {[(benzyloxy)carbonyl]amino}butanoic acid 149 (3R)-4-[(3-{[4-{[(Benzylamino)carbonyl)aminol-1 -methyl- 579 2 1H-pyrrol-2-yl)carbonyl]amino}propanoyl)amino]- - 348 Examples ESI-MS Amount [M+H*] [mg] 3-{[(benzyloxy)carbonyl]amino}butanoic acid 150 (3R)-4-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-2- 582 18 yl)carbonyl]amino}propanoyl)amino-3-{[(benzyloxy)carbonyl] aminolbutanoic acid 151 (3R)-4-[({[(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-4-yI)- 569 9 carbonyl]amino}acetyl)amino]-3-{[(benzyloxy)carbonyl] aminolbutanoic acid 152 (3R)-4-[({[(5-{[(Benzylamino)carbonyl]amino)thien-3-y)- 568 8 carbonyl]amino}acetyl)amino]-3-{[(benzyloxy)carbonyl]amino} butanoic acid 153 (3R)-4-({[[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 582 1 carbonyl] (methyl)am ino]acetyl}am ino)-3-{[(benzyloxy) carbonyl]amino}butanoic acid 154 (3R)-4-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 582 14 carbonyl]amino}propanoyl)amino]-3-{[(benzyloxy)carbonyl] amino}butanoic acid 155 (3R)-4-[({[(5-{[(Benzylamino)carbonyl]amino}-1 H-1,2,4-triazol- 553 19 3-yl)carbonyl]amino}acetyl)amino]-3-{[(benzyloxy)carbonyl) amino}butanoic acid 156 (3R)-4-({[[(5-{[(Benzylamino)carbonyl]amino}-1 H-1,2,4-triazol- 567 22 3-yl)carbonyl](methyl)amino]acetyl}amino)-3-{[(benzyloxy) carbonyl]amino}butanoic acid 157 (3R)-4-[(3-{[(5-{[(Benzylamino)carbonyl] amino}-1H-1,2,4- 567 22 triazol-3-yl)carbonyl]amino}propanoyl)amino]-3-{[(benzyloxy) carbonyllamino}butanoic acid 158 (3R)-4-({[(5-{[(Benzylamino)carbonyl]amino}-2-furoyl)amino]- 552 2 acetyl}amino)-3-{[(benzyloxy)carbonyllamino}butanoic acid 159 (3R)-4-({[(5-{[(Benzylamino)carbonyl]amino}-2-furoyl)(methyl)- 566 2 amino]acetyl}amino)-3-{[(benzyloxy)carbonyl]amino}butanoic ,acid 160 (3R)-4-({3-[(5-{[(Benzylamino)carbonyljamino}-2-furoyl)amino]- 566 23 propanoyllamino)-3-{[(benzyloxy)carbonyl]amino}butanoic acid_ 161 (3R)-4-[({[(5-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-2-yl)- 569 16 carbonyl]amino}acetyl)amino]-3-{[(benzyloxy)carbonyl]amino} butanoic acid -349 Synthesis The N substituents in the position a to the carboxylic acid can be varied widely by the following reaction sequence: ax-N-Fmoc-D-N-Aloc-diaminopropanoic acid (4.52 g) are coupled as described by P. Sieber (Tetrahedron Lett. 28 (1987) 6147) to 5 g of Wang resin. The Fmoc group is then cleaved off by using 20 ml of a mixture of 10% DBU, 2% piperidine and 88% DMF in 3 min. The resin is filtered off with suction, washed several times with DMF, CH 2
CI
2 and diethyl ether and dried. A loading of about 1.15 mmol/g results. Acyl radicals are introduced into the ax position by adding 3 eq of carboxylic acid and activating with HATU or TBTU by the usual standard processes within 4 h. Sulfonyl radicals are introduced by suspending 0.145 g of loaded resin in 1 ml of CH 2
CI
2 and adding a solution of 0.4 eq of DMAP, 4 eq of methoxy(trimethylsilyloxy)dimethylketene acetal (MTDA) and 2 eq of sulfonyl chloride in 1.5 ml of CH 2
CI
2 (see M. Gude et al., Tetrahedron Lett. 37 (1996) 8589). After 8 h the resin is filtered off with suction and washed 1 Ox with CH 2
CI
2 , 5x with DMF and 5x with CH 2
CI
2 . The Aloc group is cleaved off by flushing the polymer with N 2 and adding a solution of 24 eq of phenylsilane in oxygen-free CH 2 Cl 2 (see N. Thieriet et al., Tetrahedron Lett. 38 (1997) 7275). 0.1 eq of Pd(PPh 3
)
4 dissolved in CH 2 Cl 2 is added, and the mixture is reacted for about 90 min. Then 3 eq of Fmoc-amino acid in DMF are activated with TBTU by the usual standard processes and coupled to the free amino group within 8 h. The Fmoc protective group is cleaved off as described above. The final coupling with N-(3-carboxythien-5-yl)-N'-benzylurea takes place in analogy to the above coupling within 2 d. The resin is thoroughly washed with DMF and CH 2 Cl 2 and then 1.5 ml of a mixture of 95% TFA and 5% water are added. After 45 min, the resin is filtered off and washed with a little CH 2
CI
2 . The filtrate is combined and concentrated. The residue can be purified by one or more of the following methods for test purposes: 1. Dissolving in a little methanol and precipitating by adding water. It is filtered off with - 350 suction and dried. 2. The residue is dissolved in ethyl acetate, and the solution is extracted with water. This is followed by concentration and stirring with diethyl ether. The precipitate is 5 filtered off with suction and dried. 3. The residue is chromatographed on a silica gel column. Examples ESI-MS Amount [M+H*] [mg] 162 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 608.15 9.1 carbonyl]amino}propanoyl)amino]-2-{[(2-chlorophenyl)sulfonyl]- and amino}propanoic acid 610.15 163 (2S)-3-[(3-{[(5-{[(Benzylamino]carbonyl]amino}thien-3-yl)- 554.15 1.8 carbonyl]amino}propanoyl)amino]-2-[(butylsulfonyl)amino] propanoic acid 164 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]aminolthien-3-yl)- 588.15 21.2 carbonyl]aminolpropanoyl)amino]-2-[(benzylsulfonyl)amino] propanoic acid 165 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 624.15 16.3 carbonyl]amino}propanoyl)amino]-2-[(1 -naphthylsulfonyl) amino]propanoic acid __1 166 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 624.15 19.2 carbonyl]amino}propanoyl)amino]-2-[(2-naphthylsulfonyl)amino] propanoic acid 167 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]aminolthien-3-yl)- 676.05; 6.5 carbonyl]amino}propanoyl)amino]-2-{[(2,4,5-trichlorophenyl)- 677.95; sulfonyl)amino}propanoic acid 680.0; 682.0 168 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-y)- 642.15; 13.1 carbonyl]amino}propanoyl)amino]-2-{[(2,6-dichlorophenyl)- 644.05 sulfonyllamino}propanoic acid 169 (2S)-3-[(3-{[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)- 634.15 3.3 carbonyl]amino}propanoyl)amino]-2-{[(2,5-dimethoxyphenyl) sulfonyl]amino}propanoic acid - 351 II. Biological Examples Example 1 Integrin a3 assay Integrin cB 3 antagonists were identified and assessed using a test system based on competition between the natural integrin a(p 3 ligand vitronectin and the test substance for binding to integrin av$ 3 bound to a solid phase. Procedure - coat microtiter plates with 250 ng/ml integrin-avB 3 in 0.05 M NaHCO 3 pH 9.2; 0.1 ml/well; - saturate with 1% milk powder/assay buffer; 0.3 ml/well; 0.5 h/RT - wash 3x with 0.05% Tween 20/assay buffer - test substance in 0.1% milk powder/assay buffer, 50 p.1/well + 0 gg/ml or 2 ptg/ml human vitronectin (Boehriner [sic] Ingelheim T007) in 0.1% milk powder/assay buffer, 50 pl/well; 1 h/RT - wash 3x with 0.05% Tween 20/assay buffer - 1 pg/ml anti human vitronectin antibody coupled to peroxidase (Kordia SAVN APHRP) in 0.1% milk powder/assay buffer; 0.1 ml/well; 1 h/RT - wash 3x with 0.05% Tween 20/assay buffer - 0.1 ml/well peroxidase substrate - stop reaction with 0.1 ml/well 2 M H 2 SO4 - measure the absorption at 450 nm Integrin CCp: human placenta is solubilized with Nonidet, and integrin aCvp 3 is affinity purified on a GRGDSPK-matrix (elution with EDTA). Contamination by integrin OiibO 3 3 and - 352 human serum albumin, as well as the detergent and EDTA, are removed by anion exchange chromatography. Assay buffer: 50 mM Tris pH 7.5; 100 mM NaCl; 1 mM CaCl 2 ; 1 mM MgCl 2 ; 10 pM 5 MnCl 2 Peroxidase substrate: mix 0.1 ml of TMB solution (42 mM TMB in DMSO) and 10 ml of substrate buffer (0,1 M Na acetate pH 4.9) and then add 14.7 pl of 3% H 2 0 2 . Various dilutions of the test substances are employed in the assay, and the IC50 values are determined (concentration of the antagonist at which 50% of the ligand is displaced). D The following table shows the IC50 values of selected examples. Compound IC50 aVP3 N-({{(2-{[(Benzylamino)carbonyl]amino}-1,3-thiazol-5-yl)carbonyl]- 10 amino}acetyl)-3-pyridin-3-yl-beta-alanine N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-4-yl)carbonyl]- 0.0138 amino}acetyl)-3-pyridin-3-yl-beta-alanine N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-4-yl)carbonyl]- 0.048 amino}acetyl)-3-(2-naphthyl)-beta-alanine N-({[(2-([(Benzylamino)carbonyl]amino}-1,3-oxazol-4-yl)carbonyl]- 0.040 am ino}acetyl)-3-(4-methylphenyl)-beta-alanine (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-4-yl)- 0.1 carbonyl]amino}acetyl)amino]-2-{[(benzyloxy)carbonyl]aminol propanoic acid 3-{1 -[({[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2- 0.016 yl)carbonyl]amino}acetyl)amino]-2-carboxyethyl}pyridinium acetate N-({[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2-yl)- 0.043 carbonyl]amino}acetyl)-3-(2-naphthyl)-beta-alanine (2S)-3-[({[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2- 0.26 yl)carbonyl]amino}acetyl)amino]-2-{[(benzyloxy)carbonyl]amino} propanoic acid N-({[(4-{[(Benzylamino)carbonyl]amino}-1 -methyl-1 H-pyrrol-2- 0.039 yl)carbonyl]am ino}acetyl)-3-(4-methylphenyl)-beta-alanine N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbony]amino}- 1 acetyl)-3-pyridin-3-yl-beta-alanine N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}- 10 acetyl)-3-(3,5-dichlorophenyl)-beta-alanine -353 N-({[(5-{[(Benzylamino)carbonyl]amino}thien-2-yl)carbonyl]amino}- 10 acetyl)-3-(4-m ethylphenyl)-beta-alan ine N-({[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)carbony]amino}- 0.0005 acetyl)-3-pyridin-3-yl-beta-alanine N-({[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)carbonyl]aminol- 0.0047 acetyl)-3-(3,5-dichlorophenyl)-beta-alanine N-({[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)carbonyl]amino}- 0.0021 acetyl)-3-(4-methylphenyl)-beta-alanine (2S)-3-[({[(5-{[(Benzylamino)carbonyl]amino}thien-3-yl)carbonyl]- 0.0118 amino}acetyl)aminol-2-{[(benzyloxy)carbonyl]amino}propanoic acid N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-5-yl)carbonyl]- 0.00028 amino}acetyl)-3-pyridin-3-yl-beta-alanine N-({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-5-yl)carbonyl]- 0.00038 amino}acetyl)-3-(3,5-dichlorophenyl)-beta-alanine (2S)-3-[({[(2-{[(Benzylamino)carbonyl]amino}-1,3-oxazol-5- 0.0018 yl)carbonyl]amino}acetyl)amino]-2-{[(benzyloxy)carbonyl]aminol propanoic acid Example 2 Integrin a1ib 3 3 assay The assay is based on competition between the natural integrin aIl3 ligand fibrinogen and the test substance for binding to integrin ajIbps. Procedure: - coat microtiter plates with 10 pg/ml fibrinogen (Calbiochem 341578) in 0.05 M NaHCO 3 pH 9.2; 0.1 ml/well; - saturate with 1 % BSA/PBS; 0.3 ml/well; 30 min/RT i - wash 3x with 0.05% Tween 20/PBS - test substance in 0.1% BSA/PBS; 50 1i/well + 200 ltg/ml integrin aiB1 3 3 (Kordia) in 0.1% BSA/PBS; 50 p.l/well; 2-4 h/RT - wash 3x as above - 354 - biotinylated anti-integrin al1b1 antibody (Dianova CBL 130 B); 1:1000 in 0.1% BSA/PBS; 0.1 ml/well; 2-4 h/RT - wash 3x as above - streptavidin-peroxidase complex (B.M. 1089153) 1:10000 in 0.1% BSA/PBS; 0.1 ml/well; 30 min/RT - wash 3x as above - 0.1 ml/well peroxidase substrate - stop reaction with 0.1 ml/well 2 M H 2 SO4 - measure the absorption at 450 nm Peroxidase substrate: mix 0.1 ml of TMB solution (42 mM TMB in DMSO) and 10 ml of substrate buffer (0.1 M Na acetate pH 4.9), then add 14.7 gl of 3% H 2 0 2 Various dilutions of the test substances are employed in the assay, and the IC 50 values are determined (concentration of the antagonist at which 50% of the ligand is displaced). The selectivity of the substances can be determined by comparing the IC 50 values in the integrin a11b1 3 3 and integrin avb 3 [sic] assays. Example 3 CAM assay The CAM (chorioallantoic membrane) assay is a generally accepted model for assessing the in vivo activity of integrin aC0 3 antagonists. It is based on the inhibition of angiogenesis and neovascularization of tumor tissue (Am. J. Pathol. 1975, 79, 597-618; Cancer Res. 1980, 40, 2300-2309; Nature 1987, 329, 630). The procedure is analogous to the prior art. The growth of the chicken embryonic blood vessels and of the transplanted tumor tissue can readily be followed and assessed.
-355 Example 4 Rabbit eye assay The inhibition of angiogenesis and neovascularization in the presence of integrin CP3 antagonists can be followed and assessed in this in vivo model in analogy to Example 3. The model is generally accepted and is based on the growth of blood vessels starting from the edge into the cornea of the rabbit eye (Proc. Nati. Acad. Sci. USA. 1994, 91, 4082-4085; Science 1976, 193, 70-72). The procedure is analogous to the prior art.

Claims (28)

1. A compound of the formula I 5 A-E-G-L where A, E, G and L have the following meanings: L a structural element of the formula IL, R 4 R 2 R3 where a is 0 or 1, T is a COOH group or a radical which can be hydrolyzed to COOH, R 2 is hydrogen, NHSO 2 R 21 , NHCOR 2 or NHCOOR 22 where R 21 is a branched or unbranched, optionally substituted C-C 6 -alkyl, C 3 -C 6 cycloalkyl, C-C 4 -alkyl-C 3 -C 6 -cycloalkyl radical, C 5 -C 12 -bicycloalkyl or C 6 -C 18 -tricycloalkyl radical, an up to trisubstituted, with identical or different radicals, aryl, alkylaryl, hetarylalkyl radical or 3- to 6 membered, saturated, unsaturated or aromatic heterocycle which may contain up to three different or identical heteroatoms 0, N, S, it being possible for two radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and this ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring, - 357 R 22 is a branched or unbranched, optionally substituted C 1 -C 6 -alkyl radical or an optionally substituted aryl or alkylaryl radical, 5 R 3 is hydrogen or -(CH2)b-(X)c-R3 , where b is 0, 1, 2 or 3, D c is 0 or 1, X is -S02-, -S-, -0-, -CO-, -NH-SO 2 -, -0-CO-, -CO-0-, -NH-CO-, -CO-NH -CO-N(R 3 1 )-, -N(R 31 )-CO-, -S0 2 -NH-, -S0 2 -N(R 31 )- or -N(R31)-S0r, 5 R 3 1 is hydrogen, a hydroxyl group, a branched or unbranched, optionally substituted C 1 .C 6 -alkyl, C 1 -C 4 -alkoxy, -0-alkylaryl or -0-aryl radical, an amino radical with primary or optionally secondary or tertiary substitution, an optionally C 1 .C 4 -alkyl- or aryl-substituted C 2 -C 6 -alkynyl 3 or C 2 -C 6 -alkenyl radical, a C5-C1 2 -bicycloalkyl, C 6 -C 18 -tricycloalkyl radical or a 3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms 0, N, S, C 3 -C 8 -cycloalkyl, aryl or hetaryl radical, it being possible for two 5 radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring, and R 4 is hydrogen, or a branched or unbranched, optionally substituted C1-4 alkyl, C 3 -C 6 -alkenyl, C 3 -C 6 -alkynyl or C 3 -C 6 -cycloalkyl radical, G a structural element of the formula IG, - 358 R 6 )d R where 5 d is 0, 1 or 2, R 5 is hydrogen, a hydroxyl group, a branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, -0-alkylaryl or -0-aryl radical, an amino radical with primary or optionally secondary or tertiary D substitution, an optionally C 1 -C 4 -alkyl- or aryl-substituted C 2 -C 6 -alkynyl or C 2 -C 6 -alkenyl radical, a C5-C1 2 -bicycloalkyl, C 6 -C 18 -tricycloalkyl radical or a 3- to 6-membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms 0, N, 5 S, C 3 - 8 -cycloalkyl, aryl or hetaryl radical, it being possible for two radicals together to be a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring 0 can be fused to this ring, or the side chain of a natural amino acid, R 6 is hydrogen or a branched or unbranched, optionally substituted C1.4 alkyl, C 3 -C 6 -alkenyl, C 3 -C 6 -alkynyl or C 3 -C 6 -cycloalkyl radical, 5 E a structural element of the formula IE -(NH)g-(CH 2 )rQ-(CH 2 )e-CO- IE where D e is 0, 1 or 2, f is 0 or 1, - 359 g is 0 or 1, Q is a doubly linked, optionally substituted hetaryl radical, it being possible for two substituents together to be a saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and this ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring, A one of the structural elements of the formulae IA 1 to IA 2 0 R1 6 R16 R 6 R A R A2 R IA 3 N N 1 13 10 0IA 4 10 S P50 IA 6 R *-.N IA 7 R2 iQ s N1 R N QH N 15O IA As 3 cR: RR aN R R 115 R 15 R 0 A A 8 I A O . 6 H R IYA1 7 I 1 ,Al i N 1 '1 A2 H - 360 where R 10 ' R" are, independently of one another, hydrogen, -(CH 2 )h-(Y)i-R 0 1 , or the two radicals together are a 3- to 8-membered, optionally substituted, saturated, unsaturated or aromatic N-heterocycle which may additionally contain two other, identical or different heteroatoms 0, N or S, where h is 0, 1, 2 or 3, i is 0 or 1, Y is -S02-, -S-, -0-, -CO-, -NH-SO 2 -, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-, -CO-N(R' 0 1 )-, -N(R 101 )-CO-, -SO 2 -NH-, -N(R 10 )-S0 2 - or -S0 2 -N(Rl 0 1 )- and R 101 is a hydroxyl group, a branched or unbranched, optionally substituted C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, -0-alkylaryl or -0-aryl radical, an amino radical with primary or optionally secondary or tertiary substitution, an optionally C 1 -C 4 -alkyl- or aryl-substituted C 2 -C 6 -alkynyl or C 2 -C 6 -alkenyl radical, a C 5 -C 12 -bicycloalkyl, C 6 -C 1 8 -tricycloalkyl radical or a 3- to 6 membered, saturated or unsaturated heterocycle which is substituted by up to three identical or different radicals and which may contain up to three different or identical heteroatoms 0, N, S, C 3 - 8 -cycloalkyl, aryl or hetaryl radical, it being possible for two radicals together to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which may contain up to three different or identical heteroatoms 0, N, S, and the ring can optionally be substituted, or another, optionally substituted, saturated, unsaturated or aromatic ring can be fused to this ring, R 12 is a branched or unbranched, optionally substituted C 1 -C 4 -alkyl, alkylaryl, C 3 -C 6 -cycloalkyl or C 1 -C 4 -alkyl-C 3 -C 6 -cycloalkyl radical or an optionally substituted aryl radical, -361 R 13 is hydrogen, -OH, -CN, -CONH 2 , a branched or unbranched, optionally substituted C-C 4 -alkyl, Cr 1 C 4 -alkoxy or -O-CO-C-C 4 -alkyl radical, or an optionally substituted alkylaryl, -0-alkylaryl, -0-CO-aryl, -0-CO-alkylaryl or -0-CO-allyl radical, R1 4 is hydrogen, a branched or unbranched, optionally substituted C-C 4 -alkyl, -CO-0-C-C 4 -alkyl, alkylaryl, -CO-0-alkylaryl, -CO-0-allyl, -CO-ClrC 4 -alkyl, -CO-alkylaryl or -CO-allyl radical, R 15 is hydrogen, a branched or unbranched, optionally substituted C-C 4 -alkyl radical or an optionally substituted aryl or alkylaryl radical, R 16 , R 17 are, independently of one another, -NH 2 , halogen or a branched or unbranched, optionally substituted C-C 4 -alkyl or C-C 4 -alkoxy radical or an optionally substituted aryl radical, ZI, Z 2 , Z 3 , Z 4 are, independently of one another, CH, C-CH 3 , C-OCH 3 , C-CI or N, and the physiologically tolerated salts, prodrugs and the enantiomerically pure or diastereomerically pure and tautomeric forms.
2. A pharmaceutical preparation for oral or parenteral administration, comprising at least one compound as claimed in claim 1 besides conventional pharmaceutical excipients.
3. The use of a compound as claimed in claim 1 for producing drugs for treating diseases.
4. The use as claimed in claim 3 of a compound as claimed in claim 1 as integrin receptor antagonist.
5. The use as claimed in claim 4 of a compound as claimed in claim 1 as antagonist of the avI33 integrin receptor.
6. The use of a compound as claimed in claim 1 for producing drugs for treating diseases in which an integrin receptor is involved. - 362
7. The use as claimed in claim 6 of a compound as claimed in claim 1 for treating diseases in which the avP3 integrin receptor is involved.
8. The use as claimed in claim 7 of a compound as claimed in claim 1 for treating atherosclerosis, rheumatoid arthritis, restenosis after vessel injury, angioplasty, acute kidney failure, angiogenesis-associated microangiopathies, diabetic angiopathies, blood platelet-mediated vascular occlusion, arterial thrombosis, congestive heart failure, myocardial infarct, stroke, cancer, osteoporosis, high blood pressure, psoriasis or viral, parasitic or bacterial diseases, inflammations, ) wound healing, hyperparathyroism [sic], Paget's disease, malignant hypercalcemia or metastatic osteolytic lesions.
9. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of inhibitors of blood platelet adhesion, activation or aggregation, anticoagulants which prevent thrombin activity or formation, antagonists of blood platelet-activating compounds or selectin antagonists.
10. The use of the pharmaceutical preparation as claimed in claim 9 for producing a drug for treating blood platelet-mediated vascular occlusion or thrombosis.
11. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of inhibitors of blood platelet activation or aggregation, serine protease inhibitors, fibrinogen-reducing compounds, selectin antagonists, antagonists of ICAM-1 or VCAM-1 inhibitors of leukocyte adhesion inhibitors of vessel wall transmigration, fibrinolysis-modulating compounds, inhibitors of complement factors, endothelin receptor antagonists, tyrosine kinase inhibitors, -363 antioxidants or interleukin 8 antagonists.
12. The use of the pharmaceutical preparation as claimed in claim 11 for producing a drug for treating myocardial infarct or stroke.
13. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of endothelin antagonists, ACE inhibitors, angiotensin receptor antagonists, endopeptidase inhibitors, beta blockers, calcium channel blockers, phosphodiesterase inhibitors or caspase inhibitors.
14. The use of the pharmaceutical preparation as claimed in claim 13 for producing a drug for treating congestive heart failure.
15. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of thrombin inhibitors, inhibitors of factor Xa, inhibitors of the coagulation pathway which leads to thrombin formation, inhibitors of blood platelet adhesion, activation or aggregation, endothelin receptor antagonists, nitric oxide synthase inhibitors, CD44 antagonists, selectin antagonists, MCP-1 antagonists, inhibitors of signal transduction in proliferating cells, antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF, or antioxidants. - 364
16. The use of the pharmaceutical preparation as claimed in claim 15 for producing a drug for treating restenosis after vessel injury or stent implantation.
17. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF, heparin or low molecular weight heparins or other GAGs, inhibitors of MMPs, selectin antagonists, endothelin antagonists, ACE inhibitors, angiotensin receptor antagonists, glycosilation [sic] inhibitors or AGE formation inhibitors or antagonists of your [sic] receptors.
18. The use of the pharmaceutical preparation as claimed in claim 17 for producing a drug for treating diabetic angiopathies.
19. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of lipid-lowering compounds, selectin antagonists, antagonists of ICAM-1 or VCAM-1 heparin or low molecular weight heparin or other GAGs, inhibitors of MMPs, endothelin antagonists, apolipoprotein Al antagonists, cholesterol antagonists, HMG-CoA reductase inhibitors, ACAT inhibitors, ACE inhibitors, angiotensin receptor antagonists, tyrosine kinase inhibitors, -365 protein kinase C inhibitors, calcium channel blockers, LDL receptor function stimulants, antioxidants or free radical scavengers.
20. The use of the pharmaceutical preparation as claimed in claim 19 for producing a drug for treating atherosclerosis.
21. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of cytostatic or antineoplastic compounds, compounds which inhibit proliferation or heparin or low molecular weight heparins or other GAGs.
22. The use of the pharmaceutical preparation as claimed in claim 21 for producing a drug for treating cancer.
23. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of compounds for antiresorptive therapy, compounds for hormone replacement therapy, recombinant human growth hormone, bisphosphonates, compounds for calcitonin therapy, calcitonin stimulants, calcium channel blockers, bone formation stimulants, interleukin-6 antagonists or Src tyrosine kinase inhibitors.
24. The use of the pharmaceutical preparation as claimed in claim 23 for producing a drug for treating osteoporosis. - 366
25. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, where appropriate pharmaceutical excipients and at least one other compound selected from the group of TNF antagonists, antagonists of VLA-4 or VCAM-1, antagonists of LFA-1, Mac-1 or ICAMs, complement inhibitors, immunosuppressants, interleukin-1, -5 or -8 antagonists or dihydrofolate reductase inhibitors.
26. The use of the pharmaceutical preparation as claimed in claim 25 for producing a drug for treating rheumatoid arthritis.
27. A pharmaceutical preparation comprising at least one compound as claimed in claim 1, with appropriate pharmaceutical excipients and at least one other compound selected from the group of collagenase, PDGF antagonists or MMPs.
28. The use of the pharmaceutical preparation as claimed in claim 27 for producing a drug for improving wound healing.
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