BG103213A - 1,2,3,4-тетрахидро-бензофуро[3,2-с]пиридинови производни - Google Patents

1,2,3,4-тетрахидро-бензофуро[3,2-с]пиридинови производни

Info

Publication number
BG103213A
BG103213A BG103213A BG10321399A BG103213A BG 103213 A BG103213 A BG 103213A BG 103213 A BG103213 A BG 103213A BG 10321399 A BG10321399 A BG 10321399A BG 103213 A BG103213 A BG 103213A
Authority
BG
Bulgaria
Prior art keywords
benzofuro
tetrahydro
formula
pyridine derivatives
relates
Prior art date
Application number
BG103213A
Other languages
English (en)
Other versions
BG63848B1 (bg
Inventor
Ludo Kennis
Christopher Love
Francois BISCHOFF
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG103213A publication Critical patent/BG103213A/bg
Publication of BG63848B1 publication Critical patent/BG63848B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Изобретението се отнася до съединения с формула до N-оксиди, фармацевтично приемливи присъединителни соли и до техни стереохимични изомерни форми. Във формулата всеки R1 е независимо водород, халоген, С1-6 алкил, нитро, хидрокси, или С1-4 алкокси; Alk е С1-6 алкандиил; n има стойност 1 или 2; D е по избор заместен моно-, би- и трицикличен азот, съдържащ хетероцикъл, който има активност на централен 2-адреноцепторен антагонист. Изобретението се отнася и до получаването на посочените съединения, до състави, които ги съдържат, и до използването им като лекарства.
BG103213A 1997-04-08 1999-02-25 1,2,3,4-тетрахидро-бензофуро[3,2-с]пиридинови производни BG63848B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201045 1997-04-08
PCT/EP1998/002136 WO1998045297A1 (en) 1997-04-08 1998-04-02 1,2,3,4-TETRAHYDRO-BENZOFURO[3,2-c]PYRIDINE DERIVATIVES__

Publications (2)

Publication Number Publication Date
BG103213A true BG103213A (bg) 2000-05-31
BG63848B1 BG63848B1 (bg) 2003-03-31

Family

ID=8228191

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103213A BG63848B1 (bg) 1997-04-08 1999-02-25 1,2,3,4-тетрахидро-бензофуро[3,2-с]пиридинови производни

Country Status (31)

Country Link
US (1) US6156757A (bg)
EP (1) EP1019408B1 (bg)
JP (1) JP3287577B2 (bg)
KR (1) KR100315975B1 (bg)
CN (1) CN1097053C (bg)
AP (1) AP1138A (bg)
AR (1) AR012576A1 (bg)
AT (1) ATE270294T1 (bg)
AU (1) AU727599B2 (bg)
BG (1) BG63848B1 (bg)
BR (1) BR9806263A (bg)
CA (1) CA2264598C (bg)
CZ (1) CZ290008B6 (bg)
DE (1) DE69824872T2 (bg)
EE (1) EE03691B1 (bg)
ES (1) ES2224391T3 (bg)
GE (1) GEP20022823B (bg)
HU (1) HUP0003624A3 (bg)
ID (1) ID22131A (bg)
IL (1) IL128701A0 (bg)
MY (1) MY120033A (bg)
NO (1) NO322826B1 (bg)
NZ (1) NZ334501A (bg)
PL (1) PL189549B1 (bg)
RU (1) RU2198175C2 (bg)
SK (1) SK283621B6 (bg)
TR (1) TR199900644T2 (bg)
TW (1) TW589315B (bg)
UA (1) UA52681C2 (bg)
WO (1) WO1998045297A1 (bg)
ZA (1) ZA982969B (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі
UA70334C2 (en) 1998-10-06 2004-10-15 Janssen Pharmaceutica N V Jans BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
ID28451A (id) * 1998-10-06 2001-05-24 Janssen Pharmaceutica Nv Trisiklik piperidin-δ3 sebagai bahan farmasi
ID28967A (id) * 1998-12-21 2001-07-19 Janssen Pharmaceutica Nv Benzisoksazol dan fenon sebagai alfa 2-antagonis
JP2005522407A (ja) * 2001-07-05 2005-07-28 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療用化合物
ES2367481T3 (es) * 2002-04-03 2011-11-03 Orion Corporation Uso de un antagonista del adrenoreceptor alfa2 para enfermedades relacionadas con el snc.
CA2500952C (en) * 2002-10-04 2011-04-26 Prana Biotechnology Limited Neurologically-active compounds
MXPA06011777A (es) 2004-04-12 2007-01-16 Taisho Pharma Co Ltd Compuesto de amina ciclico.
WO2008050732A1 (fr) * 2006-10-23 2008-05-02 Takeda Pharmaceutical Company Limited Dérivé de l'iminopyridine et son utilisation
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
UY31781A (es) * 2008-04-23 2009-12-14 Takeda Pharmaceutical Derivados de iminopiridina y su uso
US8575186B2 (en) * 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
AU2012207335A1 (en) * 2011-01-19 2013-07-25 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570701B1 (fr) * 1984-09-27 1987-05-22 Synthelabo Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique
US4686226A (en) * 1985-09-03 1987-08-11 Merck & Co., Inc. Substituted benzo[b]furo- and benzo[b]thieno quinolizines
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі

Also Published As

Publication number Publication date
MY120033A (en) 2005-08-30
CA2264598A1 (en) 1998-10-15
ATE270294T1 (de) 2004-07-15
UA52681C2 (uk) 2003-01-15
NZ334501A (en) 2000-06-23
CA2264598C (en) 2006-10-24
TR199900644T2 (xx) 2000-09-21
JP2000505115A (ja) 2000-04-25
US6156757A (en) 2000-12-05
GEP20022823B (en) 2002-10-25
AR012576A1 (es) 2000-11-08
DE69824872D1 (de) 2004-08-05
CZ290008B6 (cs) 2002-05-15
DE69824872T2 (de) 2005-09-01
KR100315975B1 (ko) 2001-12-22
CZ68299A3 (cs) 2000-08-16
TW589315B (en) 2004-06-01
EP1019408B1 (en) 2004-06-30
JP3287577B2 (ja) 2002-06-04
HUP0003624A2 (hu) 2001-04-28
NO990859D0 (no) 1999-02-23
AU7430798A (en) 1998-10-30
ID22131A (id) 1999-09-09
PL189549B1 (pl) 2005-08-31
RU2198175C2 (ru) 2003-02-10
EE9900114A (et) 1999-12-15
SK283621B6 (sk) 2003-10-07
CN1097053C (zh) 2002-12-25
IL128701A0 (en) 2000-01-31
AP9901650A0 (en) 1999-09-30
ZA982969B (en) 1999-10-07
NO990859L (no) 1999-09-30
AU727599B2 (en) 2000-12-14
HUP0003624A3 (en) 2002-09-30
BG63848B1 (bg) 2003-03-31
KR20000036076A (ko) 2000-06-26
BR9806263A (pt) 2000-04-04
EP1019408A1 (en) 2000-07-19
ES2224391T3 (es) 2005-03-01
AP1138A (en) 2003-01-17
PL332382A1 (en) 1999-09-13
SK28799A3 (en) 2001-03-12
WO1998045297A1 (en) 1998-10-15
EE03691B1 (et) 2002-04-15
NO322826B1 (no) 2006-12-11
CN1237179A (zh) 1999-12-01

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