BG101933A - Method for the preparation of 2-diethylaminoethylchloridehydrochloride - Google Patents

Method for the preparation of 2-diethylaminoethylchloridehydrochloride

Info

Publication number
BG101933A
BG101933A BG101933A BG10193397A BG101933A BG 101933 A BG101933 A BG 101933A BG 101933 A BG101933 A BG 101933A BG 10193397 A BG10193397 A BG 10193397A BG 101933 A BG101933 A BG 101933A
Authority
BG
Bulgaria
Prior art keywords
deaechc
separation
thionylchloride
diethylaminoethanol
purity
Prior art date
Application number
BG101933A
Other languages
Bulgarian (bg)
Other versions
BG62694B1 (en
Inventor
Сюлейман ПЕНДЕВ
Славейка БОГДАНОВА
Иван ДЖУРДЖЕВ
Маргарита Иванова
Антон НАКОВ
Original Assignee
"Неохим" Еад
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "Неохим" Еад filed Critical "Неохим" Еад
Priority to BG101933A priority Critical patent/BG62694B1/en
Publication of BG101933A publication Critical patent/BG101933A/en
Publication of BG62694B1 publication Critical patent/BG62694B1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compound 2-diethylaminoethylchloridehydrochloride(DEAECHC) is used in the pharmaceutical industry, in particularfor the preparation of isothioronic salt,2-diethylaminoethanethiol anddiethylamineethanethiolhydrochloride. The method for itspreparation includes reaction between 2-diethylaminoethanol andthionylchloride in an organic solvent with high yield and purity.2-diethylaminoethanol is fed to a thionylchloride solution inchloroform at temperature range from 30 to 40°C for 1-2 h., it isadditionally agitated for 1-2 h. at the same temperature and afterthat the temperature is raised to 65-70°C for the separation ofthe dioxide produced. There follows separation of the chloroformand unreacted thionylchloride and their return to the subsequentsynthesis as return chloroform. The reaction mass is subjected torecrystallization of the DEAECHC, and ethyl or methyl alcohol oranother organic solvent is added to it which dissolves theimpurities, purifying the product. The produced DEAECHC crystalsare subjected to filtration and drying, and the filtrate isdistilled for the separation of the ethyl alcohol and itrecrystallizes with ethyl alcohol and diethyl ether or is returnedagain to the subsequent cycle of the DEAECHC recrystallizationstage. The purity of the products is 97-98% and its yield is94-96.1 claim
BG101933A 1997-09-30 1997-09-30 Method for the preparation of 2-diethylaminoethylchloridehydrochloride BG62694B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG101933A BG62694B1 (en) 1997-09-30 1997-09-30 Method for the preparation of 2-diethylaminoethylchloridehydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG101933A BG62694B1 (en) 1997-09-30 1997-09-30 Method for the preparation of 2-diethylaminoethylchloridehydrochloride

Publications (2)

Publication Number Publication Date
BG101933A true BG101933A (en) 1999-03-31
BG62694B1 BG62694B1 (en) 2000-05-31

Family

ID=3927252

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101933A BG62694B1 (en) 1997-09-30 1997-09-30 Method for the preparation of 2-diethylaminoethylchloridehydrochloride

Country Status (1)

Country Link
BG (1) BG62694B1 (en)

Also Published As

Publication number Publication date
BG62694B1 (en) 2000-05-31

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