BG101933A - Method for the preparation of 2-diethylaminoethylchloridehydrochloride - Google Patents
Method for the preparation of 2-diethylaminoethylchloridehydrochlorideInfo
- Publication number
- BG101933A BG101933A BG101933A BG10193397A BG101933A BG 101933 A BG101933 A BG 101933A BG 101933 A BG101933 A BG 101933A BG 10193397 A BG10193397 A BG 10193397A BG 101933 A BG101933 A BG 101933A
- Authority
- BG
- Bulgaria
- Prior art keywords
- deaechc
- separation
- thionylchloride
- diethylaminoethanol
- purity
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The compound 2-diethylaminoethylchloridehydrochloride(DEAECHC) is used in the pharmaceutical industry, in particularfor the preparation of isothioronic salt,2-diethylaminoethanethiol anddiethylamineethanethiolhydrochloride. The method for itspreparation includes reaction between 2-diethylaminoethanol andthionylchloride in an organic solvent with high yield and purity.2-diethylaminoethanol is fed to a thionylchloride solution inchloroform at temperature range from 30 to 40°C for 1-2 h., it isadditionally agitated for 1-2 h. at the same temperature and afterthat the temperature is raised to 65-70°C for the separation ofthe dioxide produced. There follows separation of the chloroformand unreacted thionylchloride and their return to the subsequentsynthesis as return chloroform. The reaction mass is subjected torecrystallization of the DEAECHC, and ethyl or methyl alcohol oranother organic solvent is added to it which dissolves theimpurities, purifying the product. The produced DEAECHC crystalsare subjected to filtration and drying, and the filtrate isdistilled for the separation of the ethyl alcohol and itrecrystallizes with ethyl alcohol and diethyl ether or is returnedagain to the subsequent cycle of the DEAECHC recrystallizationstage. The purity of the products is 97-98% and its yield is94-96.1 claim
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG101933A BG62694B1 (en) | 1997-09-30 | 1997-09-30 | Method for the preparation of 2-diethylaminoethylchloridehydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG101933A BG62694B1 (en) | 1997-09-30 | 1997-09-30 | Method for the preparation of 2-diethylaminoethylchloridehydrochloride |
Publications (2)
Publication Number | Publication Date |
---|---|
BG101933A true BG101933A (en) | 1999-03-31 |
BG62694B1 BG62694B1 (en) | 2000-05-31 |
Family
ID=3927252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG101933A BG62694B1 (en) | 1997-09-30 | 1997-09-30 | Method for the preparation of 2-diethylaminoethylchloridehydrochloride |
Country Status (1)
Country | Link |
---|---|
BG (1) | BG62694B1 (en) |
-
1997
- 1997-09-30 BG BG101933A patent/BG62694B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BG62694B1 (en) | 2000-05-31 |
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