BE904724A - 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEM; THEIR PROCESS FOR OBTAINING. - Google Patents

1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEM; THEIR PROCESS FOR OBTAINING.

Info

Publication number
BE904724A
BE904724A BE0/216623A BE216623A BE904724A BE 904724 A BE904724 A BE 904724A BE 0/216623 A BE0/216623 A BE 0/216623A BE 216623 A BE216623 A BE 216623A BE 904724 A BE904724 A BE 904724A
Authority
BE
Belgium
Prior art keywords
obtaining
pharmaceutical composition
composition containing
piperazine derivatives
disubstituted piperazine
Prior art date
Application number
BE0/216623A
Other languages
French (fr)
Inventor
James Stewart New
Joseph P Yevick
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE904724A publication Critical patent/BE904724A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dérivés de piperazine 1,4-disubstitués, une composition pharmaceutique contenant de tels dérivés ainsi que leur procédé d'obtention. Selon l'invention l'un des substituants est un système hétérocyclique bicyclique condensé comprenant des systémes à noyau furo-,pyrrolo-,cyclopentadiéno-, et thienopyridine, et l'autre substituant est une chaine alcoylidène de sorte que les composés de l'invention peuvent etre généralement représentés par la formule I.1,4-disubstituted piperazine derivatives, a pharmaceutical composition containing such derivatives as well as the process for obtaining them. According to the invention, one of the substituents is a condensed bicyclic heterocyclic system comprising systems with a furo-, pyrrolo-, cyclopentadieno- and thienopyridine nucleus, and the other substituent is an alkylidene chain, so that the compounds of the invention can generally be represented by formula I.

BE0/216623A 1985-05-06 1986-05-05 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEM; THEIR PROCESS FOR OBTAINING. BE904724A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73120185A 1985-05-06 1985-05-06

Publications (1)

Publication Number Publication Date
BE904724A true BE904724A (en) 1986-11-05

Family

ID=24938510

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216623A BE904724A (en) 1985-05-06 1986-05-05 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEM; THEIR PROCESS FOR OBTAINING.

Country Status (25)

Country Link
JP (1) JPH0753728B2 (en)
KR (1) KR940000829B1 (en)
CN (1) CN1017901B (en)
AT (1) AT398572B (en)
AU (1) AU593244B2 (en)
BE (1) BE904724A (en)
CA (1) CA1278792C (en)
CH (1) CH672787A5 (en)
DE (1) DE3615180C2 (en)
DK (1) DK165745C (en)
EG (1) EG18206A (en)
ES (6) ES8801250A1 (en)
FI (1) FI85484C (en)
FR (1) FR2581385B1 (en)
GB (1) GB2174703B (en)
GR (1) GR861149B (en)
HU (1) HU195509B (en)
IE (1) IE59201B1 (en)
IT (1) IT1208607B (en)
LU (1) LU86421A1 (en)
MY (1) MY100777A (en)
NL (1) NL8601146A (en)
PT (1) PT82523B (en)
SE (1) SE465270B (en)
ZA (1) ZA862046B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
IE903410A1 (en) * 1989-10-09 1991-04-10 Novo Nordisk As Indole derivatives, their preparation and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
FR2738822B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 4- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) QUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2738823B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 3- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) -3,4-DIHYDROQUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
BR9610579A (en) * 1995-09-15 1999-07-06 Sanofi Synthelabo Quinoline-2 (1H) -one derivatives as serotonin antagonists
FR2738824B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 3- (OMEGA (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN-1 -YL) ALKYL) -3,4-DIHYDROQUINAZOLIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2761071B1 (en) * 1997-03-20 1999-12-03 Synthelabo DERIVATIVES OF QUINOLEIN-2 (1H) -ONE AND DIHYDROQUINOLEIN-2 (1H) - ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2797874B1 (en) * 1999-08-27 2002-03-29 Adir NOVEL PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Also Published As

Publication number Publication date
HU195509B (en) 1988-05-30
ES9000005A1 (en) 1989-11-01
ZA862046B (en) 1986-11-26
ES8900253A1 (en) 1989-05-16
GB2174703B (en) 1988-10-26
CA1278792C (en) 1991-01-08
FR2581385B1 (en) 1991-10-04
LU86421A1 (en) 1986-12-05
GB8610810D0 (en) 1986-06-11
DE3615180C2 (en) 1996-03-07
ES8802614A1 (en) 1988-09-01
JPS61268681A (en) 1986-11-28
PT82523B (en) 1988-10-14
CN1017901B (en) 1992-08-19
SE465270B (en) 1991-08-19
FI861820A0 (en) 1986-04-30
SE8602061D0 (en) 1986-05-05
DK207186A (en) 1986-11-07
ES8801250A1 (en) 1987-12-16
IT1208607B (en) 1989-07-10
ES557757A0 (en) 1988-04-01
CH672787A5 (en) 1989-12-29
FR2581385A1 (en) 1986-11-07
GR861149B (en) 1986-09-09
ES557839A0 (en) 1989-01-16
IE861193L (en) 1986-11-06
FI85484C (en) 1992-04-27
PT82523A (en) 1986-06-01
ES557855A0 (en) 1989-05-16
KR940000829B1 (en) 1994-02-02
DE3615180A1 (en) 1986-11-06
ES8802149A1 (en) 1988-04-01
ES8900138A1 (en) 1989-01-16
SE8602061L (en) 1986-11-07
JPH0753728B2 (en) 1995-06-07
MY100777A (en) 1991-02-14
NL8601146A (en) 1986-12-01
ATA121486A (en) 1994-05-15
ES554659A0 (en) 1987-12-16
IE59201B1 (en) 1994-01-26
DK165745B (en) 1993-01-11
FI85484B (en) 1992-01-15
DK207186D0 (en) 1986-05-05
DK165745C (en) 1993-06-14
CN86103071A (en) 1987-03-18
GB2174703A (en) 1986-11-12
EG18206A (en) 1992-09-30
AU593244B2 (en) 1990-02-08
AT398572B (en) 1994-12-27
KR860009008A (en) 1986-12-19
HUT43848A (en) 1987-12-28
ES557809A0 (en) 1988-09-01
IT8620313A0 (en) 1986-05-06
FI861820A (en) 1986-11-07
AU5679586A (en) 1986-11-13

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BRISTOL-MYERS CY

Effective date: 20060505