BE904233A - PEPTIDES AND PEPTIDE DERIVATIVES, THEIR PREPARATION, THEIR USE IN THERAPEUTICS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents
PEPTIDES AND PEPTIDE DERIVATIVES, THEIR PREPARATION, THEIR USE IN THERAPEUTICS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.Info
- Publication number
- BE904233A BE904233A BE1/011438A BE1011438A BE904233A BE 904233 A BE904233 A BE 904233A BE 1/011438 A BE1/011438 A BE 1/011438A BE 1011438 A BE1011438 A BE 1011438A BE 904233 A BE904233 A BE 904233A
- Authority
- BE
- Belgium
- Prior art keywords
- peptides
- therapeutics
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Les peptides de formule I éventuellement sous forme isotère dans lesquels un groupe méthylène situé dans la chaine est disubstitué, un des substituants ou les deux étant le fluor et/ou de chlore. Ces composés peuvent etre utilisés comme médicaments, en particulier comme inhibiteurs de la rénine.The peptides of formula I optionally in isoteric form in which a methylene group located in the chain is disubstituted, one of the substituents or both being fluorine and / or chlorine. These compounds can be used as drugs, in particular as renin inhibitors.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70265185A | 1985-02-19 | 1985-02-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE904233A true BE904233A (en) | 1986-08-18 |
Family
ID=24822094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE1/011438A BE904233A (en) | 1985-02-19 | 1986-02-17 | PEPTIDES AND PEPTIDE DERIVATIVES, THEIR PREPARATION, THEIR USE IN THERAPEUTICS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS61194097A (en) |
BE (1) | BE904233A (en) |
CH (1) | CH672792A5 (en) |
DE (1) | DE3604510A1 (en) |
FR (1) | FR2577557B1 (en) |
GB (1) | GB2171103B (en) |
IT (1) | IT1203743B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194588A (en) * | 1985-01-22 | 1993-03-16 | Ici Americas Inc. | Aminoalcohol intermediates for peptide derivatives |
GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
US5055450A (en) * | 1985-01-22 | 1991-10-08 | Ici Americas Inc. | Peptide derivatives |
US5496927A (en) * | 1985-02-04 | 1996-03-05 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
US4882420A (en) * | 1985-04-19 | 1989-11-21 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
GB8613704D0 (en) * | 1986-06-05 | 1986-07-09 | Ici America Inc | Difluoro keto compounds |
GB8613703D0 (en) * | 1986-06-05 | 1986-07-09 | Ici America Inc | Difluoro peptide compounds |
GB8619182D0 (en) * | 1986-08-06 | 1986-09-17 | Sandoz Ltd | Peptides & derivatives |
NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
US4855303A (en) * | 1987-07-01 | 1989-08-08 | Pfizer Inc. | Fluorine containing renin inhibitors |
US5071837A (en) * | 1990-11-28 | 1991-12-10 | Warner-Lambert Company | Novel renin inhibiting peptides |
US5559140A (en) * | 1991-01-02 | 1996-09-24 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
CA2098020C (en) * | 1991-01-02 | 2003-10-21 | Daniel Schirlin | Anti-viral compounds |
IL108031A0 (en) * | 1992-12-22 | 1994-04-12 | Procter & Gamble | Difluoro pentapeptide derivatives and pharmaceutical compositions containing them |
AU667995B2 (en) * | 1993-02-15 | 1996-04-18 | Bayer Aktiengesellschaft | New pseudopeptides having an antiviral action |
EP0707564B1 (en) * | 1993-07-08 | 2000-09-20 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
KR100308839B1 (en) * | 1993-09-09 | 2002-10-04 | 메렐 파마슈티칼스 인크. | Difluoro startone antiviral analogs |
WO1995021186A1 (en) * | 1994-02-04 | 1995-08-10 | Merrell Pharmaceuticals Inc. | Macrocyclic difluorostatone derivatives useful as antiviral agents |
GB9502152D0 (en) * | 1995-02-03 | 1995-03-29 | Zeneca Ltd | Proline derivatives |
US6114380A (en) * | 1995-12-18 | 2000-09-05 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
US8324347B2 (en) * | 2009-02-24 | 2012-12-04 | Institute For Systems Biology | Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2424253A1 (en) * | 1978-04-27 | 1979-11-23 | Brun Lab Sa Le | NEW DERIVATIVES OF PEPTIDES ANALOGUES OF ENKEPHALINS, THEIR METHOD OF PREPARATION AND THEIR THERAPEUTIC APPLICATION |
EP0048159A3 (en) * | 1980-09-17 | 1982-05-12 | University Of Miami | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents |
EP0218688B1 (en) * | 1985-04-19 | 1990-09-12 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
-
1986
- 1986-02-11 CH CH537/86A patent/CH672792A5/de not_active IP Right Cessation
- 1986-02-13 DE DE19863604510 patent/DE3604510A1/en not_active Withdrawn
- 1986-02-17 BE BE1/011438A patent/BE904233A/en not_active IP Right Cessation
- 1986-02-17 FR FR868602218A patent/FR2577557B1/en not_active Expired - Lifetime
- 1986-02-17 GB GB08603835A patent/GB2171103B/en not_active Expired
- 1986-02-18 JP JP61034930A patent/JPS61194097A/en active Pending
- 1986-02-18 IT IT47666/86A patent/IT1203743B/en active
Also Published As
Publication number | Publication date |
---|---|
FR2577557A1 (en) | 1986-08-22 |
CH672792A5 (en) | 1989-12-29 |
IT8647666A0 (en) | 1986-02-18 |
DE3604510A1 (en) | 1986-08-21 |
GB8603835D0 (en) | 1986-03-26 |
FR2577557B1 (en) | 1990-05-11 |
JPS61194097A (en) | 1986-08-28 |
GB2171103A (en) | 1986-08-20 |
IT1203743B (en) | 1989-02-23 |
GB2171103B (en) | 1989-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: SANDOZ S.A. Effective date: 19930228 |