BE903746A - Compose a activite antimicrobienne, sa preparation et formes pharmaceutiques en contenant. - Google Patents
Compose a activite antimicrobienne, sa preparation et formes pharmaceutiques en contenant. Download PDFInfo
- Publication number
- BE903746A BE903746A BE0/215934A BE215934A BE903746A BE 903746 A BE903746 A BE 903746A BE 0/215934 A BE0/215934 A BE 0/215934A BE 215934 A BE215934 A BE 215934A BE 903746 A BE903746 A BE 903746A
- Authority
- BE
- Belgium
- Prior art keywords
- oxy
- compound
- preparation
- emi
- antimicrobial activity
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 150000001875 compounds Chemical class 0.000 title claims description 11
- 230000000845 anti-microbial effect Effects 0.000 title claims description 4
- -1 1- (2,4-Dichloro-beta - ((2,4-dichlorobenzyl) oxy) phenethyl) -1- ((dihydrocinnamoyl) oxy) methylimidazolium chloride Chemical compound 0.000 claims abstract description 7
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 230000000843 anti-fungal effect Effects 0.000 claims description 3
- 229940121375 antifungal agent Drugs 0.000 claims description 3
- WHOXQNQYEQVPEL-UHFFFAOYSA-N 2,4-dichloro-1-[[2-chloro-1-(2,4-dichlorophenyl)ethoxy]methyl]benzene Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCl)OCC1=CC=C(Cl)C=C1Cl WHOXQNQYEQVPEL-UHFFFAOYSA-N 0.000 claims description 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000002070 germicidal effect Effects 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- QLACLEPYLWLNTD-UHFFFAOYSA-N dihydrocinnamic acid Natural products COc1ccc(CCC(O)=O)c(O)c1OC QLACLEPYLWLNTD-UHFFFAOYSA-N 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000000050 nutritive effect Effects 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- JDIIGWSSTNUWGK-UHFFFAOYSA-N 1h-imidazol-3-ium;chloride Chemical compound [Cl-].[NH2+]1C=CN=C1 JDIIGWSSTNUWGK-UHFFFAOYSA-N 0.000 description 1
- KBMWRDHROVTFDI-UHFFFAOYSA-N 2,4-dichloro-1-(ethoxymethyl)benzene Chemical compound CCOCC1=CC=C(Cl)C=C1Cl KBMWRDHROVTFDI-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 238000009631 Broth culture Methods 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 238000012009 microbiological test Methods 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8423796A IT1213251B (it) | 1984-11-29 | 1984-11-29 | Composto con attivita'antimicrobica, sua preparazione e forme farmaceutiche che lo contengono. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE903746A true BE903746A (fr) | 1986-03-14 |
Family
ID=11210066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/215934A BE903746A (fr) | 1984-11-29 | 1985-11-29 | Compose a activite antimicrobienne, sa preparation et formes pharmaceutiques en contenant. |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE903746A (it) |
| IT (1) | IT1213251B (it) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0195116A2 (en) * | 1985-03-19 | 1986-09-24 | ISTITUTO FARMACO BIOLOGICO RIPARI GERO S.r.l. | Compound having antibacterial and antimycotic activities, preparation thereof and pharmaceutical compositions containing it |
-
1984
- 1984-11-29 IT IT8423796A patent/IT1213251B/it active
-
1985
- 1985-11-29 BE BE0/215934A patent/BE903746A/fr not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0195116A2 (en) * | 1985-03-19 | 1986-09-24 | ISTITUTO FARMACO BIOLOGICO RIPARI GERO S.r.l. | Compound having antibacterial and antimycotic activities, preparation thereof and pharmaceutical compositions containing it |
| EP0195116A3 (en) * | 1985-03-19 | 1987-06-03 | Ripari Gero Ist Farm Biolog | Compound having antibacterial and antimycotic activities, preparation thereof and pharmaceutical compositions containing it |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1213251B (it) | 1989-12-14 |
| IT8423796A0 (it) | 1984-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE851310A (fr) | Nouveaux derives de la tetrahydro-equinocandine b | |
| FR2458545A1 (fr) | Procede de preparation de derives de benzylimidazole, nouveaux produits ainsi obtenus, et leur utilisation pour leurs activites antimycotique et fongicide | |
| EP1026170B1 (fr) | Nouveaux dérivés de l'erythromycine, leur procédé de préparation et leur application comme médicaments | |
| EP0015038A1 (fr) | Composition pharmaceutique comprenant un dérivé de diphénylhydantoine, dérivés mis en oeuvre et leur préparation | |
| EP0117771B1 (fr) | Imino-2 pyrrolidines, leur procédé de préparation et leurs applications en thérapeutique | |
| US4478846A (en) | 2-(1-Alkyl-5-nitro)-imidazolyl-1-(2-hydroxy-5-alkyl)-phenyl carbinols and pharmaceutical compositions containing them | |
| FR2476071A1 (fr) | Nouveaux acides 2-amino-3-(a-hydroxybenzyl)-phenylacetiques et leurs esters et amides, utiles notamment comme agents anti-inflammatoires, et compositions pharmaceutiques les contenant | |
| BE903746A (fr) | Compose a activite antimicrobienne, sa preparation et formes pharmaceutiques en contenant. | |
| EP0037344B1 (fr) | Amino-alcoxy pyrazoles, procédé pour leur préparation, et médicaments les contenant | |
| CH639075A5 (fr) | Ethers dibenzyliques substitues actifs sur le plan therapeutique. | |
| US6124352A (en) | Antifungal agents | |
| EP0220112B1 (fr) | Dérivés aromatiques substitués par un groupement (oméga-amino) alcanol à activité antimicrobienne, leur préparation et les compositions les contenant | |
| LU83804A1 (fr) | Derives nouveaux de 1-phenethylimidazole et compositions antimicrobiennes les contenant | |
| EP0063401B1 (en) | Nitroimidazoles having trichomonacidal activity, a process for their preparation and related pharmaceutical compositions | |
| EP0482993A1 (fr) | Dérivés N,O spirocycliques de cyclotriphosphazènes, leur préparation et leur application en thérapeutique | |
| EP1189933B1 (fr) | Derives de l'echinocandine, leur procede de preparation et leur application comme antifongiques | |
| FR2561105A1 (fr) | Sels d'erythromycine avec des derives de l'acide acetique. procede pour leur preparation et compositions pharmaceutiques en contenant | |
| BE883665A (fr) | Nouveaux derives du benzymidazole | |
| CZ1009887A3 (en) | Novel imidazole derivatives, process of their preparation and antimycotic preparations in which said imidazoles are comprised | |
| US4273783A (en) | (1-Alkyl-5-nitro-2-imidazolyl)-vinyl-glyoxal-diacetals, their preparation and their use | |
| FR2488256A1 (fr) | Nouveaux derives de l'acide nitro-5-imidazolyl-ethenyl-2-(amino-2-pyrimidyl)-n-succinique, leur procede de preparation et medicaments en contenant | |
| EP1007522A1 (fr) | 2- 4-[4-(4,5-dichloro -2-methylimidazol-1-yl) butyl]-1-piperazinyl -5-fluoropyrimidine, sa preparation et son utilisation therapeutique | |
| EP0347305A1 (fr) | [(Aryl-4-pipérazinyl-1)-2 éthoxy]-3 p-cymène, les dérivés ortho, méta, para monosubstitués ou disubstitués sur le noyau phényle dudit produit, le procédé de préparation desdits dérivés, et les médicaments contenant lesdits composés comme principe actif | |
| FR2522326A1 (fr) | Nouveau sel de l'hexamethylenetetramine, son procede de preparation et son application en therapeutique | |
| EP1257568B1 (fr) | Derives de l'echinocandine, leur procede de preparation et leur application comme fongicides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: PULITZER ITALIANA S.P.A. Effective date: 19931130 |