BE899423A - HYDROXYLATED DIPHENYLAZOMETHINES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS. - Google Patents

HYDROXYLATED DIPHENYLAZOMETHINES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS.

Info

Publication number
BE899423A
BE899423A BE0/212765A BE212765A BE899423A BE 899423 A BE899423 A BE 899423A BE 0/212765 A BE0/212765 A BE 0/212765A BE 212765 A BE212765 A BE 212765A BE 899423 A BE899423 A BE 899423A
Authority
BE
Belgium
Prior art keywords
alkyl
radical
diphenylazomethines
hydroxylated
therapeutics
Prior art date
Application number
BE0/212765A
Other languages
French (fr)
Inventor
J-P Kaplan
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of BE899423A publication Critical patent/BE899423A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Diphénylazométhines hydroxylées répondant à la formule (I) dans laquelle : n est un nombre entier allant de 1 à 4, X1 , X2 et X3 représentent chacun, indépendamment l'un de l'autre, un atome d'hydrogène, un atome d'halogène, le radical méthoxy ou un radical (C1-4) alkyle droit ou ramifié, R représente le radical NH2, OH ou OM (M=métal alcalin ou alcalinoterreux) et Z représente un radical COOH, COOalkyle, CONH2, CONH alkyle, CON(alkyle)2, CH2OH, CH2Oalkyle, Oalkyle, NO2, NH2, NHalkyle ou N(alkyle)2, les alkyles ayant de 1à 4 atomes de carbone. Composés pharmaceutiques les contenant et ayant des activités antidépressives, anticonvulsivantes, antiulcéreuses, anxiolitiques, analgésiques et antiinflammatoires.Hydroxylated diphenylazomethines corresponding to formula (I) in which: n is an integer ranging from 1 to 4, X1, X2 and X3 each represent, independently of one another, a hydrogen atom, an atom of halogen, the methoxy radical or a straight or branched (C1-4) alkyl radical, R represents the NH2, OH or OM radical (M = alkali or alkaline earth metal) and Z represents a COOH, COOalkyl, CONH2, CONH alkyl, CON radical (alkyl) 2, CH2OH, CH2Oalkyl, Oalkyl, NO2, NH2, NHalkyl or N (alkyl) 2, the alkyls having from 1 to 4 carbon atoms. Pharmaceutical compounds containing them and having antidepressant, anticonvulsant, antiulcer, anxiolitic, analgesic and anti-inflammatory activities.

BE0/212765A 1983-04-14 1984-04-13 HYDROXYLATED DIPHENYLAZOMETHINES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS. BE899423A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8306082A FR2544309B1 (en) 1983-04-14 1983-04-14 HYDROXYLATED DIPHENYLAZOMETHINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
BE899423A true BE899423A (en) 1984-10-15

Family

ID=9287836

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/212765A BE899423A (en) 1983-04-14 1984-04-13 HYDROXYLATED DIPHENYLAZOMETHINES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS.

Country Status (20)

Country Link
JP (1) JPS59199665A (en)
AU (1) AU2682584A (en)
BE (1) BE899423A (en)
DE (1) DE3414051A1 (en)
DK (1) DK191684A (en)
ES (1) ES531605A0 (en)
FI (1) FI841484A (en)
FR (1) FR2544309B1 (en)
GB (1) GB2138000A (en)
GR (1) GR79857B (en)
HU (1) HUT34153A (en)
IL (1) IL71540A0 (en)
IT (1) IT1176042B (en)
LU (1) LU85311A1 (en)
NL (1) NL8401189A (en)
NO (1) NO841486L (en)
NZ (1) NZ207840A (en)
PT (1) PT78429B (en)
SE (1) SE8402082L (en)
ZA (1) ZA842798B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1212000B (en) * 1987-12-24 1989-11-08 Sigma Tau Ind Farmaceuti PHENYLBENZYLIDEN-DERIVATIVES OF ACID 3) AMINOPROPANSULPHONIC WITH ANTI-CONVULSIVE ACTIVITY AND THEIR PHARMACEUTICAL COMPOSITIONS FOR THE THERAPEUTIC TREATMENT OF EPILEPSY
FR2788691B1 (en) 1999-01-21 2002-06-14 Oreal COMPOSITIONS FOR OXIDATION DYEING OF KERATINIC FIBERS COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING, AND DYEING METHODS
FR2788768B1 (en) 1999-01-21 2001-02-16 Oreal NEW CATIONIC 2-ACYLAMINOPHENOLS, THEIR USE AS COUPLER FOR OXIDATION DYEING, COMPOSITIONS COMPRISING THEM, AND DYEING METHODS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319338A1 (en) * 1975-08-01 1977-02-25 Synthelabo NEW A-PHENYL BENZYLIDENIC DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
FR2430936A1 (en) * 1978-07-13 1980-02-08 Synthelabo Alpha-phenyl 2-hydroxy-benzylidene amino-alkanoic acid derivs. - and novel di:phenyl-ketone intermediates, useful as anticonvulsants for treating epilepsy
FR2516509B1 (en) * 1981-11-18 1985-07-26 Synthelabo BENZYLIDENIC DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
JPS59199665A (en) 1984-11-12
ES8502677A1 (en) 1985-01-16
AU2682584A (en) 1984-10-18
FI841484A0 (en) 1984-04-13
DE3414051A1 (en) 1984-10-18
NZ207840A (en) 1986-02-21
ES531605A0 (en) 1985-01-16
GR79857B (en) 1984-10-31
PT78429A (en) 1984-05-01
NL8401189A (en) 1984-11-01
SE8402082L (en) 1984-10-15
ZA842798B (en) 1984-11-28
PT78429B (en) 1986-08-22
IT1176042B (en) 1987-08-12
DK191684D0 (en) 1984-04-13
IT8420528A0 (en) 1984-04-13
SE8402082D0 (en) 1984-04-13
HUT34153A (en) 1985-02-28
IL71540A0 (en) 1984-07-31
DK191684A (en) 1984-10-15
NO841486L (en) 1984-10-15
GB2138000A (en) 1984-10-17
FR2544309B1 (en) 1986-01-10
FI841484A (en) 1984-10-15
FR2544309A1 (en) 1984-10-19
LU85311A1 (en) 1985-11-27

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SYNTHELABO

Effective date: 19860430