BE892270A - Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique

Info

Publication number
BE892270A
BE892270A BE0/207402A BE207402A BE892270A BE 892270 A BE892270 A BE 892270A BE 0/207402 A BE0/207402 A BE 0/207402A BE 207402 A BE207402 A BE 207402A BE 892270 A BE892270 A BE 892270A
Authority
BE
Belgium
Prior art keywords
oxazolidinic
derivatives
preparation
therapeutic application
novel aminomethyl
Prior art date
Application number
BE0/207402A
Other languages
English (en)
French (fr)
Inventor
P Dostert
A Lacour
M Langlois
M Strolin-Benedetti
Original Assignee
Delalande Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande Sa filed Critical Delalande Sa
Publication of BE892270A publication Critical patent/BE892270A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE0/207402A 1981-02-25 1982-02-25 Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique BE892270A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8103797A FR2500450A1 (fr) 1981-02-25 1981-02-25 Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BE892270A true BE892270A (fr) 1982-08-25

Family

ID=9255633

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/207402A BE892270A (fr) 1981-02-25 1982-02-25 Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique

Country Status (14)

Country Link
US (1) US4476136A (US20110009641A1-20110113-C00185.png)
JP (1) JPS5838273A (US20110009641A1-20110113-C00185.png)
AU (1) AU553462B2 (US20110009641A1-20110113-C00185.png)
BE (1) BE892270A (US20110009641A1-20110113-C00185.png)
CA (1) CA1178594A (US20110009641A1-20110113-C00185.png)
CH (1) CH653999A5 (US20110009641A1-20110113-C00185.png)
DE (1) DE3206770A1 (US20110009641A1-20110113-C00185.png)
ES (2) ES509848A0 (US20110009641A1-20110113-C00185.png)
FR (1) FR2500450A1 (US20110009641A1-20110113-C00185.png)
GB (2) GB2094299B (US20110009641A1-20110113-C00185.png)
IT (1) IT1153437B (US20110009641A1-20110113-C00185.png)
LU (1) LU83963A1 (US20110009641A1-20110113-C00185.png)
NL (1) NL8200732A (US20110009641A1-20110113-C00185.png)
SE (1) SE457258B (US20110009641A1-20110113-C00185.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184170A2 (en) 1984-12-05 1986-06-11 E.I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5654435A (en) * 1991-11-01 1997-08-05 Pharmacia & Upjohn Company Substituted arylphenyloxazolindinones

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
ES2031921T3 (es) * 1986-09-03 1993-01-01 Delalande S.A. Derivados 5-aminoetilados de la oxazolidinona-2, su procedimiento de fabricacion y su aplicacion terapeutica.
FR2603279B1 (fr) * 1986-09-03 1988-12-16 Rech Ind Benzyloxy-phenyl-oxazolidinones, procede de preparation et utilisation en therapeutique
FR2609029B1 (fr) * 1986-12-30 1989-12-08 Delalande Sa Derives 5-aminoethyles de l'oxazolidinone-2, leur procede de preparation et leur application en therapeutique
DE3723797A1 (de) * 1987-07-18 1989-01-26 Merck Patent Gmbh Oxazolidinone
US5032605A (en) * 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5039690A (en) * 1987-10-09 1991-08-13 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US4985429A (en) * 1987-10-09 1991-01-15 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US5036092A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US4942183A (en) * 1987-10-16 1990-07-17 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
CA1317594C (en) * 1987-10-21 1993-05-11 Chung-Ho Park Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
US5380778A (en) * 1992-09-30 1995-01-10 Minnesota Mining And Manufacturing Company Fluorochemical aminoalcohols
DE69316240T2 (de) * 1992-12-08 1998-05-20 Upjohn Co Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel
TW286317B (US20110009641A1-20110113-C00185.png) * 1993-12-13 1996-09-21 Hoffmann La Roche
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
JPH11512386A (ja) 1995-09-01 1999-10-26 ファルマシア・アンド・アップジョン・カンパニー ４−８員複素環へのｃ−ｃ結合を有するフェニルオキサゾリジノン
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
FR2741071B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
ATE209193T1 (de) * 1996-04-11 2001-12-15 Upjohn Co Verfahren zur herstellung von oxazolidinonen
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
RU2205822C2 (ru) 1997-11-07 2003-06-10 Фармация Энд Апджон Компани Способы получения (s)-оксазолидинонов, (s)-вторичный спирт, соединение, способ получения спирта
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
IL140084A0 (en) * 1998-06-05 2002-02-10 Astra Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6444813B2 (en) * 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2002018354A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Oxazolidinones and their use as antibacterial agents
US6410728B1 (en) * 2000-08-31 2002-06-25 Abbott Laboratories Oxazolidinone chemotherapeutic agents
EP1328509B1 (en) * 2000-10-17 2006-03-22 Pharmacia & Upjohn Company LLC Methods of producing oxazolidinone compounds
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
WO2006013049A2 (en) * 2004-08-02 2006-02-09 F.Hoffmann-La Roche Ag Benzyloxy derivatives as maob inhibitors
RU2659792C1 (ru) 2008-10-10 2018-07-04 Мерк Шарп Энд Домэ Корп. Оксазолидиноны и способ их очистки
KR101739923B1 (ko) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180089A (en) * 1967-10-20 1970-02-04 Delalande Sa Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2435473A2 (fr) * 1978-08-17 1980-04-04 Delalande Sa Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
FR2428032A1 (fr) * 1978-06-09 1980-01-04 Delalande Sa Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
FR2458547B2 (fr) * 1978-06-09 1986-05-16 Delalande Sa Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
CA1171865A (en) * 1980-06-04 1984-07-31 Alain Lacour N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184170A2 (en) 1984-12-05 1986-06-11 E.I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5654435A (en) * 1991-11-01 1997-08-05 Pharmacia & Upjohn Company Substituted arylphenyloxazolindinones
US5654428A (en) * 1991-11-01 1997-08-05 Pharmacia & Upjohn Company Substituted heteroarylphenyloxazolidinones
US5756732A (en) * 1991-11-01 1998-05-26 Pharmacia & Upjohn Company Substituted heteroarylphenyloxazolidinones
US5801246A (en) * 1991-11-01 1998-09-01 Pharmacia & Upjohn Company Substituted heteroarylphenyloxazolidinones
US5929248A (en) * 1991-11-01 1999-07-27 Pharmacia & Upjohn Company Substituted heteroarylphenyloxazolidinones

Also Published As

Publication number Publication date
ES520180A0 (es) 1983-12-01
JPS5838273A (ja) 1983-03-05
CH653999A5 (fr) 1986-01-31
ES8400729A1 (es) 1983-12-01
GB2141716B (en) 1985-08-29
CA1178594A (en) 1984-11-27
LU83963A1 (fr) 1983-09-02
GB2141716A (en) 1985-01-03
NL8200732A (nl) 1982-09-16
GB2094299B (en) 1985-08-21
GB8417905D0 (en) 1984-08-15
ES8306707A1 (es) 1983-06-16
JPH0261465B2 (US20110009641A1-20110113-C00185.png) 1990-12-20
SE457258B (sv) 1988-12-12
DE3206770A1 (de) 1982-11-11
IT8219730A0 (it) 1982-02-18
GB2094299A (en) 1982-09-15
AU8075682A (en) 1982-09-02
ES509848A0 (es) 1983-06-16
US4476136A (en) 1984-10-09
FR2500450A1 (fr) 1982-08-27
FR2500450B1 (US20110009641A1-20110113-C00185.png) 1983-12-02
IT1153437B (it) 1987-01-14
AU553462B2 (en) 1986-07-17
SE8201145L (sv) 1982-08-26

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