BE866035A - Procede de preparation de l'antibiotique n-acetyl-deshydrothienamycine et son utilisation - Google Patents

Procede de preparation de l'antibiotique n-acetyl-deshydrothienamycine et son utilisation

Info

Publication number
BE866035A
BE866035A BE186831A BE186831A BE866035A BE 866035 A BE866035 A BE 866035A BE 186831 A BE186831 A BE 186831A BE 186831 A BE186831 A BE 186831A BE 866035 A BE866035 A BE 866035A
Authority
BE
Belgium
Prior art keywords
deshydrothienamycin
antibiotic
acetyl
preparing
Prior art date
Application number
BE186831A
Other languages
English (en)
French (fr)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BE866035A publication Critical patent/BE866035A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BE186831A 1977-04-18 1978-04-17 Procede de preparation de l'antibiotique n-acetyl-deshydrothienamycine et son utilisation BE866035A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/788,491 US4162323A (en) 1977-04-18 1977-04-18 Antibiotic N-acetyl-dehydro-thienamycin

Publications (1)

Publication Number Publication Date
BE866035A true BE866035A (fr) 1978-10-17

Family

ID=25144652

Family Applications (1)

Application Number Title Priority Date Filing Date
BE186831A BE866035A (fr) 1977-04-18 1978-04-17 Procede de preparation de l'antibiotique n-acetyl-deshydrothienamycine et son utilisation

Country Status (15)

Country Link
US (1) US4162323A (ja)
JP (1) JPS53130494A (ja)
BE (1) BE866035A (ja)
CH (1) CH640237A5 (ja)
DE (1) DE2816608A1 (ja)
DK (1) DK145381C (ja)
ES (1) ES468739A1 (ja)
FR (1) FR2387984A1 (ja)
GB (1) GB1584228A (ja)
IE (1) IE46719B1 (ja)
IT (1) IT1104845B (ja)
LU (1) LU79452A1 (ja)
NL (1) NL7803623A (ja)
PT (1) PT67884B (ja)
SE (1) SE7803846L (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010573A1 (en) 1978-07-24 1980-05-14 Merck & Co. Inc. Novel Z-2-acylamino-3-monosubstituted propenic acids and their esters and salts, and processes for preparing them

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654146C2 (de) * 1976-11-30 1982-04-01 Standard Elektrik Lorenz Ag, 7000 Stuttgart Einrichtung für ein Prüfgerät
GR62185B (en) * 1977-03-31 1979-03-02 Panlabs Inc Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
EP0007152A1 (en) * 1978-04-28 1980-01-23 Beecham Group Plc Beta-lactam antibiotics, preparation and use
DE2963717D1 (en) * 1978-05-06 1982-11-04 Beecham Group Plc Carbapenem derivatives, a process for their preparation and pharmaceutical compositions containing them
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
DE2963580D1 (en) * 1978-08-02 1982-10-21 Beecham Group Plc Beta-lactam antibacterial agents, a process for their preparation and pharmaceutical compositions containing them
DE2966446D1 (en) * 1978-09-09 1984-01-05 Beecham Group Plc Beta-lactam compounds, their preparation and use
US4409147A (en) * 1980-03-10 1983-10-11 Takeda Chemical Industries, Ltd. Carbapenem compounds and their production
JPS57109786A (en) * 1980-12-26 1982-07-08 Takeda Chem Ind Ltd Antibiotic c-19393e5 and its preparation
US10629978B2 (en) 2017-10-30 2020-04-21 International Business Machines Corporation Multi-path interferometric Josephson isolator based on nondegenerate three-wave mixing Josephson devices
US10262275B1 (en) 2017-12-01 2019-04-16 International Business Machines Corporation Selective switching of frequency multiplexed microwave signals using cascading multi-path interferometric Josephson switches with nonoverlapping bandwidths
US10396732B2 (en) 2017-12-01 2019-08-27 International Business Machines Corporation Amplification of frequency multiplexed microwave signals using cascading multi-path interferometric josephson directional amplifiers with nonoverlapping bandwidths
US10396731B2 (en) 2017-12-01 2019-08-27 International Business Machines Corporation Selective amplification of frequency multiplexed microwave signals using cascading multi-path interferometric Josephson directional amplifiers with nonoverlapping bandwidths
US10311379B1 (en) 2017-12-01 2019-06-04 International Business Machines Corporation Isolation of frequency multiplexed microwave signals using cascading multi-path interferometric josephson isolators with nonoverlapping bandwidths
US10169722B1 (en) 2017-12-01 2019-01-01 International Business Machines Corporation Selective isolation of frequency multiplexed microwave signals using cascading multi-path interferometric josephson isolators with nonoverlapping bandwidths
US10511072B2 (en) 2017-12-01 2019-12-17 International Business Machines Corporation Switching of frequency multiplexed microwave signals using cascading multi-path interferometric Josephson switches with nonoverlapping bandwidths

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
DK143713C (da) * 1975-11-21 1982-03-08 Merck & Co Inc Fremgangsmaade til fremstilling af et antibiotisk stof n-acetyl-thienamycin og salte deraf
DK143712C (da) * 1975-11-21 1982-03-22 Merck & Co Inc Fremgangsmaade til fremstilling af de antibiotiske stoffer 890a1 og 890a3
NL7704040A (nl) * 1976-04-28 1977-11-01 Merck & Co Inc Werkwijze voor het bereiden van nieuwe anti- biotica.
DE2808563A1 (de) * 1977-03-05 1978-09-07 Beecham Group Ltd Derivate der 3-thio-6-(1-hydroxyaethyl)-7-oxo-1-aza-bicyclo eckige klammer auf 3.2.0 eckige klammer zu hept-2-en- 2-carbonsaeure, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010573A1 (en) 1978-07-24 1980-05-14 Merck & Co. Inc. Novel Z-2-acylamino-3-monosubstituted propenic acids and their esters and salts, and processes for preparing them

Also Published As

Publication number Publication date
IE780725L (en) 1978-10-18
DK145381B (da) 1982-11-08
DK145381C (da) 1983-04-11
ES468739A1 (es) 1979-10-01
DE2816608A1 (de) 1978-10-19
IE46719B1 (en) 1983-09-07
SE7803846L (sv) 1978-10-19
IT7848931A0 (it) 1978-04-17
FR2387984B1 (ja) 1980-01-18
PT67884B (en) 1980-04-07
US4162323A (en) 1979-07-24
DK150278A (da) 1979-02-08
JPS53130494A (en) 1978-11-14
NL7803623A (nl) 1978-10-20
FR2387984A1 (fr) 1978-11-17
GB1584228A (en) 1981-02-11
IT1104845B (it) 1985-10-28
PT67884A (en) 1978-05-01
CH640237A5 (de) 1983-12-30
LU79452A1 (fr) 1978-11-28

Similar Documents

Publication Publication Date Title
BE865260A (fr) Procede de preparation d'octafluoropropane
BR7908443A (pt) Dispositivo de implante
BE869632A (fr) Composition anti-mousse et son procede de preparation
BR7807428A (pt) Pa de helice de helicoptero
LU79452A1 (fr) Procede de preparation de l'antibiotique n-acetyl-deshydrothienamycine et son utilisation
BE866841A (fr) Procede de preparation d'imidazoazines et -diazines substituees et leur utilisation
RO81115A (ro) Procedeu pentru prepararea unor d-6-n-propilergoline
GB2061112B (en) Surgical drainage apparatus with reduced airspace
IT1100343B (it) Impianto d'ascensore
BE865805A (fr) 1,2,3-thiadiazol-3-in-5-ylidene-urees, leur procede de preparation et leur utilisation
DE2860651D1 (en) 3"-n-demethyl-3"-n-substituted-4,6-di-0-(aminoglycosyl)-1,3-diaminocyclitols, methods for their preparation and their application as antibiotics
BE855824A (fr) Nouvel ester de p-hydroxyphenyluree de l'ibuprofene et son procede de preparation
FI803979L (fi) Anordning foer inverkan pao en elektronstraole
FR2348910A1 (fr) Procede de preparation d'aralkylarylamines et d'alkylarylamines
BE855092A (fr) 3,5,5-trimethylhexanoyl-ferrcene et son procede de preparation
IT7869099A0 (it) Antibiotici e procedimento per la loro preparazione
AR215695A1 (es) Metodo de preparacion de auranofina
BE869723A (fr) Charge fumigene et son procede de preparation
JPS5666255A (en) Incubator
IL55139A0 (en) Substituted 2-cyclopropyl-chromones and process for their preparation
BE864401A (fr) Nouvel antibiotique et son procede de preparation
IT1141632B (it) Antibiotico marcrolidico e procedimento per la sua preparazione
JPS55129045A (en) Ultrasoniccwave diagnosis method
BE854314A (fr) Procede de preparation de beta-halo-acetals et de beta-halo-cetals
BE866556A (fr) Derives de 1,2,3-thiadiazolin-2-ide, leur procede de preparation et leur utilisation

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: MERCK & CO. INC.

Effective date: 19840417