BE796654A - 3-heterocyclo-thiomethylcephalosporines - Google Patents

3-heterocyclo-thiomethylcephalosporines

Info

Publication number
BE796654A
BE796654A BE128695A BE128695A BE796654A BE 796654 A BE796654 A BE 796654A BE 128695 A BE128695 A BE 128695A BE 128695 A BE128695 A BE 128695A BE 796654 A BE796654 A BE 796654A
Authority
BE
Belgium
Prior art keywords
thiomethylcephalosporins
heterocyclo
Prior art date
Application number
BE128695A
Other languages
English (en)
French (fr)
Inventor
G L Dunn
J R E Hoover
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US262903A external-priority patent/US3867380A/en
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of BE796654A publication Critical patent/BE796654A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE128695A 1972-06-14 1973-03-12 3-heterocyclo-thiomethylcephalosporines BE796654A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US262903A US3867380A (en) 1971-02-18 1972-06-14 3-Heterocyclic thiomethylcephalosporins

Publications (1)

Publication Number Publication Date
BE796654A true BE796654A (fr) 1973-09-12

Family

ID=22999565

Family Applications (4)

Application Number Title Priority Date Filing Date
BE128695A BE796654A (fr) 1972-06-14 1973-03-12 3-heterocyclo-thiomethylcephalosporines
BE130109A BE798331A (fr) 1972-06-14 1973-04-17 Alpha-amino-p-hydroxyphenylacetamidocephalosporines
BE132235A BE800872A (fr) 1972-06-14 1973-06-13 P-hydroxymethylphenylacetamidocephalosporines
BE132234A BE800871A (fr) 1972-06-14 1973-06-13 7-hydroxy-halophenylacetamido-3-hetero-cyclothiomet hylcephalosporines

Family Applications After (3)

Application Number Title Priority Date Filing Date
BE130109A BE798331A (fr) 1972-06-14 1973-04-17 Alpha-amino-p-hydroxyphenylacetamidocephalosporines
BE132235A BE800872A (fr) 1972-06-14 1973-06-13 P-hydroxymethylphenylacetamidocephalosporines
BE132234A BE800871A (fr) 1972-06-14 1973-06-13 7-hydroxy-halophenylacetamido-3-hetero-cyclothiomet hylcephalosporines

Country Status (4)

Country Link
BE (4) BE796654A (cs)
CS (1) CS185623B2 (cs)
SU (1) SU550984A3 (cs)
ZA (3) ZA731266B (cs)

Also Published As

Publication number Publication date
SU550984A3 (ru) 1977-03-15
ZA731266B (en) 1973-11-28
BE800872A (fr) 1973-12-13
BE798331A (fr) 1973-10-17
BE800871A (fr) 1973-12-13
ZA734054B (en) 1974-07-31
ZA734055B (en) 1974-07-31
CS185623B2 (en) 1978-10-31

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: SMITHKLINE BECKMAN CORP.

Effective date: 19930312