BE789673A - 20-epsilon-hydroxy-21-carboxy-steroids - topical anti-inflammatories - Google Patents

20-epsilon-hydroxy-21-carboxy-steroids - topical anti-inflammatories

Info

Publication number
BE789673A
BE789673A BE789673DA BE789673A BE 789673 A BE789673 A BE 789673A BE 789673D A BE789673D A BE 789673DA BE 789673 A BE789673 A BE 789673A
Authority
BE
Belgium
Prior art keywords
inflammatories
epsilon
steroids
carboxy
hydroxy
Prior art date
Application number
Other languages
French (fr)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Priority claimed from DE19712150268 external-priority patent/DE2150268C3/en
Priority claimed from DE2150270A external-priority patent/DE2150270C3/en
Priority claimed from DE19722209298 external-priority patent/DE2209298A1/en
Priority claimed from DE2209312A external-priority patent/DE2209312A1/en
Publication of BE789673A publication Critical patent/BE789673A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Title cpds. are of formula (I) where R1 = H or Me; R2 = H or (1-15C) acyl; R3 = H or a (1-18C) opt. subst. and opt. unsatd. hydrocarbon residue; or R2 and R3 = dialkylmethylene or cycloalkylidene, R4 = H or Cl and R5 = H, or R4 + R5 = a 1,2-double bond; X = H, hal or Me; Y = H or hal, Z = OH or hal = or Y, and >=1 of X, R1 and Y is not = H. (I) are prepd. from compds. of formula (II) where Q = and R7 = acyl by (a) treating IIA with a Cu (II) acylate and an alcohol or (b). IIB or IIC with a strong base.
BE789673D 1971-10-04 20-epsilon-hydroxy-21-carboxy-steroids - topical anti-inflammatories BE789673A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19712150268 DE2150268C3 (en) 1971-10-04 1971-10-04 Pregnanic acid derivatives, processes for their preparation and pharmaceuticals containing them
DE2150270A DE2150270C3 (en) 1971-10-04 1971-10-04 Pregnanic acid derivatives and process for their preparation
DE19722209298 DE2209298A1 (en) 1972-02-22 1972-02-22 20-epsilon-hydroxy-21-carboxy-steroids - topical anti-inflammatories
DE2209312A DE2209312A1 (en) 1972-02-22 1972-02-22 20-epsilon-hydroxy-21-carboxy-steroids - topical anti-inflammatories

Publications (1)

Publication Number Publication Date
BE789673A true BE789673A (en) 1973-04-04

Family

ID=27431337

Family Applications (1)

Application Number Title Priority Date Filing Date
BE789673D BE789673A (en) 1971-10-04 20-epsilon-hydroxy-21-carboxy-steroids - topical anti-inflammatories

Country Status (1)

Country Link
BE (1) BE789673A (en)

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SCHERING A.G.

Effective date: 19891031