FR2161007A1 - 1-(4,4-diarylbutyl)-piperidines - by reduction of the 4,4-diarylbutyryl derivs - Google Patents

1-(4,4-diarylbutyl)-piperidines - by reduction of the 4,4-diarylbutyryl derivs

Info

Publication number
FR2161007A1
FR2161007A1 FR7241668A FR7241668A FR2161007A1 FR 2161007 A1 FR2161007 A1 FR 2161007A1 FR 7241668 A FR7241668 A FR 7241668A FR 7241668 A FR7241668 A FR 7241668A FR 2161007 A1 FR2161007 A1 FR 2161007A1
Authority
FR
France
Prior art keywords
diarylbutyryl
diarylbutyl
derivs
piperidines
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7241668A
Other languages
French (fr)
Other versions
FR2161007B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of FR2161007A1 publication Critical patent/FR2161007A1/en
Application granted granted Critical
Publication of FR2161007B1 publication Critical patent/FR2161007B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Title cpds. of formula I, where Q = H2; Z = R = H or Me; Ar' = halophenyl, Ar2 = Ph opt. substd. by hal; and Ar3 = Ph opt. substd. by alkyl, CF3, and/or 1 or 2 hal; are prepd. by reducing the corresp. I (Q=O) with Li A lH4, NaBH4-Al2Cl6 or B2H6. I are psychotropics and CNS depressants.
FR7241668A 1971-11-25 1972-11-23 1-(4,4-diarylbutyl)-piperidines - by reduction of the 4,4-diarylbutyryl derivs Granted FR2161007A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9485771A JPS5527915B2 (en) 1971-11-25 1971-11-25

Publications (2)

Publication Number Publication Date
FR2161007A1 true FR2161007A1 (en) 1973-07-06
FR2161007B1 FR2161007B1 (en) 1976-03-05

Family

ID=14121686

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7241668A Granted FR2161007A1 (en) 1971-11-25 1972-11-23 1-(4,4-diarylbutyl)-piperidines - by reduction of the 4,4-diarylbutyryl derivs

Country Status (14)

Country Link
JP (1) JPS5527915B2 (en)
AR (2) AR198393A1 (en)
BG (2) BG20348A3 (en)
CA (1) CA983503A (en)
CH (1) CH579048A5 (en)
CS (1) CS168014B2 (en)
ES (1) ES408926A1 (en)
FR (1) FR2161007A1 (en)
HU (1) HU165208B (en)
IL (1) IL40917A (en)
NL (1) NL7214913A (en)
RO (2) RO62760A (en)
SU (1) SU462333A3 (en)
YU (1) YU35120B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380278A1 (en) * 1977-02-14 1978-09-08 Janssen Pharmaceutica Nv NEWS 1 - ((DIARYLMETHYL) AMINOALKYL) PIPERIDINES

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106187863A (en) * 2016-07-15 2016-12-07 湖南中南制药有限责任公司 The preparation method of penfluridol

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH450437A (en) * 1962-06-13 1968-01-31 Janssen Pharmaceutica Nv Process for the preparation of new benzimidazolone derivatives and their salts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH450437A (en) * 1962-06-13 1968-01-31 Janssen Pharmaceutica Nv Process for the preparation of new benzimidazolone derivatives and their salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380278A1 (en) * 1977-02-14 1978-09-08 Janssen Pharmaceutica Nv NEWS 1 - ((DIARYLMETHYL) AMINOALKYL) PIPERIDINES

Also Published As

Publication number Publication date
NL7214913A (en) 1973-05-29
FR2161007B1 (en) 1976-03-05
BG20348A3 (en) 1975-11-05
JPS5527915B2 (en) 1980-07-24
RO62760A (en) 1978-02-15
RO63063A (en) 1978-07-15
BG20349A3 (en) 1975-11-05
IL40917A0 (en) 1973-01-30
HU165208B (en) 1974-07-27
YU291672A (en) 1980-03-15
YU35120B (en) 1980-09-25
ES408926A1 (en) 1976-03-01
CH579048A5 (en) 1976-08-31
AR199497A1 (en) 1974-09-09
AR198393A1 (en) 1974-06-21
CS168014B2 (en) 1976-05-28
CA983503A (en) 1976-02-10
IL40917A (en) 1976-10-31
JPS4860092A (en) 1973-08-23
SU462333A3 (en) 1975-02-28

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