BE756806A - Process for 6-(d(-)-alpha-amino-phenylacet- - amido)-penicillanic acid - Google Patents

Process for 6-(d(-)-alpha-amino-phenylacet- - amido)-penicillanic acid

Info

Publication number
BE756806A
BE756806A BE756806DA BE756806A BE 756806 A BE756806 A BE 756806A BE 756806D A BE756806D A BE 756806DA BE 756806 A BE756806 A BE 756806A
Authority
BE
Belgium
Prior art keywords
alpha
phenylacet
amido
amino
penicillanic acid
Prior art date
Application number
Other languages
French (fr)
Inventor
M S Rabinovich
G S Pavljuk
S P Kurakina
G N Kulikova
E N Lazareva
L A Kovaleva
Original Assignee
Vnii Antibiotikov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Publication of BE756806A publication Critical patent/BE756806A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

6-APA is acylated with D(-)alpha-aminophenylacetic acid protected by reaction with a beta-keto ester, a beta-dicarboxylic acid or O-nitrophenylsulphenyl chloride in an organic solvent at pH 8-10 at 20-80 degrees C. As the product hydrolysed in aq. acetone pref. at pH 2-3.5, evapd., the residue extd. with an organic solvent, pref. BuOAc and the title product (I) isolated. (I) is a broad spectrum anti-biotic and is produced by a simple procedure without isolation of intermediates.
BE756806D 1970-09-29 Process for 6-(d(-)-alpha-amino-phenylacet- - amido)-penicillanic acid BE756806A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
BE756806 1970-09-29
FR7036023A FR2109178A5 (en) 1970-09-29 1970-10-06 Process for 6-(d(-)-alpha-amino-phenylacet- - amido)-penicillanic acid
GB4987370A GB1332508A (en) 1970-09-29 1970-10-21 Method for obtaining 6-d- alpha-amino-phenylacetamido- penicillanic acid
DE19702053214 DE2053214A1 (en) 1970-09-29 1970-10-29 Process for 6-(d(-)-alpha-amino-phenylacet- - amido)-penicillanic acid

Publications (1)

Publication Number Publication Date
BE756806A true BE756806A (en) 1971-03-29

Family

ID=10453845

Family Applications (1)

Application Number Title Priority Date Filing Date
BE756806D BE756806A (en) 1970-09-29 Process for 6-(d(-)-alpha-amino-phenylacet- - amido)-penicillanic acid

Country Status (4)

Country Link
BE (1) BE756806A (en)
DE (1) DE2053214A1 (en)
FR (1) FR2109178A5 (en)
GB (1) GB1332508A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190897B (en) * 1982-06-29 1988-02-24 Opos Biochimica Srl PROCEDURE FOR THE PREPARATION OF THE 1-ETHOXYCARBONYLOXYETHYL ACID ACID 6- (D (-) - ALPHA AMINOALPHA-PHENYLACETAMIDE) -PENICILLANIC

Also Published As

Publication number Publication date
DE2053214A1 (en) 1972-05-10
FR2109178A5 (en) 1972-05-26
GB1332508A (en) 1973-10-03

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