BE638844A - - Google Patents
Info
- Publication number
- BE638844A BE638844A BE638844DA BE638844A BE 638844 A BE638844 A BE 638844A BE 638844D A BE638844D A BE 638844DA BE 638844 A BE638844 A BE 638844A
- Authority
- BE
- Belgium
- Prior art keywords
- emi
- general formula
- new
- penicillins
- inorganic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Description
<EMI ID=1.1>
formule générale 1
<EMI ID=2.1>
<EMI ID=3.1> <EMI ID=4.1>
cation d'une base azotée soit organique, soit inorganique avant tout d'aminé ou de diamine nuit aliphatique., soit
<EMI ID=5.1>
On vient de trouver que le* nouvelles pénicillines ayant la formule générale 1 font leur preuve non seulement-
<EMI ID=6.1>
celles des pénicillines déjà connues - contre les Staphy-
<EMI ID=7.1>
manifeste même pour Ion grandes dilutions.
Voici comment on prépare Ion nouvelles pénicillines
<EMI ID=8.1>
<EMI ID=9.1>
<EMI ID=10.1>
colt non dérivé - tel que par exemple l'halogénure (chlorure)
<EMI ID=11.1>
On peut facilement préparer les acides ayant la
<EMI ID=12.1> <EMI ID=13.1>
On peut procéder/de la façon suivantes on prépare d'abord l'anhydride mixte par réaction d'acide ayant la formule
<EMI ID=14.1>
On isole les nouvelles pénicillines ayant la formule
<EMI ID=15.1>
bres, soit en forme de leurs sels formés avec bases appropriées - soit organiques, soit inorganiques.
On a vérifié la constitution des nouvelles pénicillines^ par spectre infra-rouge; on a vérifié leur contenu par la
<EMI ID=16.1>
de cette efficacité avec celle des pénicillines déjà connues,
<EMI ID=17.1> <EMI ID=18.1>
tion saturé* d'acétate de potassium dans l'alcool n-buty-
<EMI ID=19.1>
une poudre blanche, cristalline qui est facilement soluble dune l'eau*
<EMI ID=20.1>
On obtient la solution du sel sodique de la nouvelle pénicilline en partant d'un gramme d'acide 2-formyle-4,6dichlorphénoxy-acétique, de la dicyclohéxyle-carbodiimide et du sel sodique d'acide 6-aminopénicillanique - tout en procédant de la façon décrite à l'Exemple 1. On isole de la solution obtenue ainsi une substance en forme de poudre blanche, qui est facilement soluble dans l'eau - en séparant
<EMI ID=21.1>
par lyophilisation. La nouvelle pénicilline est très stable dans le milieu acide.
<EMI ID=22.1>
On obtient le sel potassique de la nouvelle pénicilline en forme d'une substance blanche, cristalline en partent
<EMI ID = 1.1>
general formula 1
<EMI ID = 2.1>
<EMI ID = 3.1> <EMI ID = 4.1>
cation of a nitrogenous base either organic or inorganic, above all amine or aliphatic overnight diamine., or
<EMI ID = 5.1>
We have just found that the * new penicillins having the general formula 1 prove their worth not only-
<EMI ID = 6.1>
those of the already known penicillins - against Staphy-
<EMI ID = 7.1>
manifest even for large dilutions.
Here's how to prepare Ion new penicillins
<EMI ID = 8.1>
<EMI ID = 9.1>
<EMI ID = 10.1>
non-derivative colt - such as for example halide (chloride)
<EMI ID = 11.1>
Acids having the
<EMI ID = 12.1> <EMI ID = 13.1>
It is possible to proceed in the following manner: the mixed anhydride is first prepared by reaction of an acid having the formula
<EMI ID = 14.1>
The new penicillins having the formula
<EMI ID = 15.1>
bres, either in the form of their salts formed with suitable bases - either organic or inorganic.
The constitution of the new penicillins has been verified by infra-red spectrum; we checked their content by
<EMI ID = 16.1>
of this effectiveness with that of the already known penicillins,
<EMI ID = 17.1> <EMI ID = 18.1>
saturated * ration of potassium acetate in n-butyl alcohol
<EMI ID = 19.1>
a white, crystalline powder which is easily soluble in water *
<EMI ID = 20.1>
The sodium salt solution of the new penicillin is obtained by starting from one gram of 2-formyl-4,6dichlorphenoxy-acetic acid, dicyclohexyl-carbodiimide and sodium salt of 6-aminopenicillanic acid - while proceeding from as described in Example 1. From the solution thus obtained, a substance in the form of a white powder, which is easily soluble in water, is isolated by separating
<EMI ID = 21.1>
by freeze-drying. The new penicillin is very stable in the acidic environment.
<EMI ID = 22.1>
The potassium salt of the new penicillin is obtained in the form of a white, crystalline substance.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR951194A FR1377635A (en) | 1963-10-19 | 1963-10-19 | Process for the preparation of new semi-synthetic penicillins and products conforming to those obtained by the present process or similar process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE638844A true BE638844A (en) |
Family
ID=8814778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE638844D BE638844A (en) | 1963-10-19 |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE638844A (en) |
| FR (1) | FR1377635A (en) |
-
0
- BE BE638844D patent/BE638844A/fr unknown
-
1963
- 1963-10-19 FR FR951194A patent/FR1377635A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1377635A (en) | 1964-11-06 |
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