BE638369A - - Google Patents

Info

Publication number
BE638369A
BE638369A BE638369DA BE638369A BE 638369 A BE638369 A BE 638369A BE 638369D A BE638369D A BE 638369DA BE 638369 A BE638369 A BE 638369A
Authority
BE
Belgium
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication of BE638369A publication Critical patent/BE638369A/xx
Priority claimed from GB3844462A external-priority patent/GB1049789A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE638369D 1962-10-10 BE638369A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3844462A GB1049789A (en) 1963-04-17 1962-10-10 New thebaine derivatives and methods of preparing the same

Publications (1)

Publication Number Publication Date
BE638369A true BE638369A (fr)

Family

ID=10403484

Family Applications (1)

Application Number Title Priority Date Filing Date
BE638369D BE638369A (fr) 1962-10-10

Country Status (2)

Country Link
US (1) US3299072A (fr)
BE (1) BE638369A (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342824A (en) * 1964-12-07 1967-09-19 Lilly Co Eli Normorphines
GB1123768A (en) * 1966-07-29 1968-08-14 Smith Kline French Lab New thebaine and oripavine derivatives and processes for preparing the same
US3466277A (en) * 1966-12-13 1969-09-09 Boehringer Sohn Ingelheim N-allylic cyclohexyl lower alkyl normorphines
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines
NO802139L (no) * 1979-08-09 1981-02-10 Mallinckrodt Inc Utgangsforbindelser for fremstilling av morfinderivater, samt fremgangsmaate til fremstilling av utgangsforbindelsene
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4722928A (en) * 1985-12-02 1988-02-02 E. I. Du Pont De Nemours And Company N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes
US4990617A (en) * 1985-12-02 1991-02-05 E. I. Du Pont De Nemours And Company N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans and derivatives
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
ATE178329T1 (de) * 1989-10-16 1999-04-15 Us Health Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n- nor-zwischenverbindungen
US5028612A (en) * 1990-03-22 1991-07-02 Hillel Glover Method for treating emotional numbness
MXPA05009757A (es) * 2003-03-13 2005-12-05 Controlled Chemicals Inc Conjugados de oxicodona con menor potencial de abuso y duracion de accion extendida.
EP1782834A3 (fr) * 2003-03-13 2007-08-01 Controlled Chemicals, Inc. Oxycodone conjugue avec un potentielle d'abus inférieur et une durée d'action étendue
AU2006259780B2 (en) * 2005-06-16 2012-04-12 SpecGx LLC A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
MX2009005455A (es) * 2006-11-22 2009-08-28 Progenics Pharm Inc (r)-n-estereoisomeros de analogos de 7,8-saturados-4,5 epoxi-morfinano.
CA2681740A1 (fr) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Preparation amelioree d'oxymorphone a partir d'oripavine
CN101711236B (zh) 2007-04-12 2012-10-31 Nsab神经研究瑞典公司分公司 表现出改善的心血管副作用特性的多巴胺受体稳定剂/调节剂的n-氧化物和/或二-n-氧化物衍生物
CA2684458A1 (fr) * 2007-04-16 2008-10-30 Mallinckrodt Inc. Reduction d'opiaces innovante utilisant une reaction de transfert d'hydrogene catalytique
AU2008338969B2 (en) * 2007-12-17 2013-08-01 SpecGx LLC Process and compounds for the production of (+) opiates
AU2008338972A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. N-demethylation of N-methyl morphinans
ES2566559T3 (es) * 2008-09-30 2016-04-13 Mallinckrodt Llc Procesos para la alquilación de grupos amino secundarios de derivados de morfinano
WO2011008636A1 (fr) * 2009-07-15 2011-01-20 Mallinckrodt Inc. Dérivés de 3-oxy-hydromorphone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3153042A (en) * 1964-10-13 Morphinone and codeinone derivatives
US2890221A (en) * 1957-07-24 1959-06-09 Rapoport Henry Method for preparing normorphine
US3101339A (en) * 1958-10-30 1963-08-20 Boehringer Sohn Ingelheim Quaternary salts of normorphine and its acylated derivatives

Also Published As

Publication number Publication date
US3299072A (en) 1967-01-17

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